Detailed information for compound 1518295

Basic information

Technical information
  • TDR Targets ID: 1518295
  • Name: N-(2,5-dichlorophenyl)-3-(2,6-dimethylmorphol ine-4-carbonyl)benzenesulfonamide
  • MW: 443.344 | Formula: C19H20Cl2N2O4S
  • H donors: 1 H acceptors: 3 LogP: 3.65 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1OC(C)CN(C1)C(=O)c1cccc(c1)S(=O)(=O)Nc1cc(Cl)ccc1Cl
  • InChi: 1S/C19H20Cl2N2O4S/c1-12-10-23(11-13(2)27-12)19(24)14-4-3-5-16(8-14)28(25,26)22-18-9-15(20)6-7-17(18)21/h3-9,12-13,22H,10-11H2,1-2H3
  • InChiKey: IWJSFSNMTOSQRR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2,5-dichlorophenyl)-3-[(2,6-dimethyl-4-morpholinyl)-oxomethyl]benzenesulfonamide
  • N-(2,5-dichlorophenyl)-3-(2,6-dimethylmorpholin-4-yl)carbonyl-benzenesulfonamide
  • MLS000774433
  • SMR000371716
  • T0505-3602

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis glycine receptor subunit beta 0.0048 0.0347 0.0301
Loa Loa (eye worm) hypothetical protein 0.0022 0.0076 0.0103
Echinococcus multilocularis geminin 0.0523 0.527 0.5248
Loa Loa (eye worm) hypothetical protein 0.0048 0.0347 0.0469
Loa Loa (eye worm) hypothetical protein 0.0065 0.0518 0.0701
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.015 0.1403 0.1899
Loa Loa (eye worm) norepinephrine transporter 0.0382 0.3807 0.5156
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0065 0.0518 1
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0047 0.0063
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.041 0.0587
Loa Loa (eye worm) hypothetical protein 0.0026 0.0115 0.0156
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0067 0.0033
Loa Loa (eye worm) hypothetical protein 0.0048 0.0347 0.0469
Echinococcus multilocularis orexin receptor type 2 0.0021 0.0067 0.0021
Schistosoma mansoni nAChR subunit 0.0048 0.0347 0.0485
Brugia malayi neuropeptide F receptor 0.0021 0.0067 0.0091
Brugia malayi Abnormal catecholamine distribution protein 1 0.0553 0.5579 0.7555
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0091
Schistosoma mansoni nAChR subunit 0.0048 0.0347 0.0485
Schistosoma mansoni hypothetical protein 0.0024 0.0094 0.0076
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0248 1
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0048 0.0347 0.0469
Schistosoma mansoni acetylcholine receptor subunit beta 0.0022 0.0076 0.0048
Onchocerca volvulus 0.0021 0.0067 0.0055
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0021 0.0067 0.0033
Brugia malayi hypothetical protein 0.0022 0.0076 0.0103
Schistosoma mansoni intermediate filament proteins 0.0028 0.0134 0.0142
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0065 0.0518 1
Onchocerca volvulus 0.0035 0.0207 0.0427
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0134 0.0182
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0063
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0026 0.0115 0.0156
Onchocerca volvulus 0.0022 0.0076 0.0079
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0048 0.0347 0.0469
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0065 0.0518 0.0761
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0065 0.0518 0.0701
Brugia malayi Dopamine receptor protein 2 0.0021 0.0067 0.0091
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0248 0.0325
Schistosoma mansoni hypothetical protein 0.0021 0.0067 0.0033
Echinococcus multilocularis neuropeptide receptor 0.0021 0.0067 0.0021
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0321 0.0443
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.0218 0.0295
Brugia malayi hypothetical protein 0.0022 0.0076 0.0103
Onchocerca volvulus 0.0028 0.0134 0.0234
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0048 0.0347 0.0301
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0193 0.6487
Onchocerca volvulus 0.0117 0.1059 0.2691
Loa Loa (eye worm) hypothetical protein 0.0065 0.0518 0.0701
Leishmania major C-8 sterol isomerase-like protein 0.0727 0.7384 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0076 0.0103
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0091
Echinococcus granulosus G protein coupled receptor 139 0.0021 0.0067 0.0033
Plasmodium vivax amine transporter, putative 0.0065 0.0518 1
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0248 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0021 0.0067 0.0021
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0091
Loa Loa (eye worm) hypothetical protein 0.0065 0.0518 0.0701
Brugia malayi hypothetical protein 0.0022 0.0076 0.0103
Loa Loa (eye worm) hypothetical protein 0.0026 0.0115 0.0156
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0021 0.0067 0.0021
Echinococcus multilocularis g protein coupled receptor 0.0021 0.0067 0.0021
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0021 0.0067 0.0033
Loa Loa (eye worm) hypothetical protein 0.0065 0.0518 0.0701
Loa Loa (eye worm) hypothetical protein 0.0039 0.0248 0.0335
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0248 0.0202
Onchocerca volvulus 0.0039 0.0248 0.0534
Onchocerca volvulus 0.0021 0.0067 0.0055
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0338 0.0471
Schistosoma mansoni hypothetical protein 0.0048 0.0338 0.0471
Schistosoma mansoni aryl hydrocarbon receptor 0.0047 0.0334 0.0465
Brugia malayi Diacylglycerol kinase protein 2 0.0024 0.0094 0.0127
Loa Loa (eye worm) hypothetical protein 0.0022 0.0076 0.0103
Loa Loa (eye worm) hypothetical protein 0.0022 0.0076 0.0103
Brugia malayi hypothetical protein 0.0158 0.1487 0.2013
Loa Loa (eye worm) hypothetical protein 0.0065 0.0518 0.0701
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0248 0.0251
Loa Loa (eye worm) LGC-31 protein 0.0048 0.0347 0.0469
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0021 0.0067 0.0091
Schistosoma mansoni nAChR subunit 0.0048 0.0347 0.0485
Loa Loa (eye worm) pigment dispersing factor receptor c 0.015 0.1403 0.1899
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0248 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0048 0.0347 0.0469
Echinococcus granulosus neuropeptide s receptor 0.0021 0.0067 0.0033
Echinococcus granulosus neuropeptides capa receptor 0.0021 0.0067 0.0033
Loa Loa (eye worm) hypothetical protein 0.0024 0.0094 0.0127
Loa Loa (eye worm) abnormal catecholamine distribution protein 1 0.0553 0.5579 0.7555
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0248 0.0251
Loa Loa (eye worm) hypothetical protein 0.0026 0.0115 0.0156
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0048 0.0347 0.0469
Plasmodium falciparum amino acid transporter, putative 0.0065 0.0518 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0065 0.0518 0.0701
Onchocerca volvulus 0.0039 0.0248 0.0534
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0021 0.0067 0.0021
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0048 0.0347 0.0301
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0021 0.0067 0.0091
Echinococcus granulosus neuropeptide FF receptor 2 0.0021 0.0067 0.0033
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0248 0.4267
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0248 0.0251
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0048 0.0347 0.0469
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0021 0.0067 0.0091
Loa Loa (eye worm) serotonin transporter b 0.0382 0.3807 0.5156
Brugia malayi GnHR receptor homolog 0.0021 0.0067 0.0091
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0067 0.0033
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0021 0.0067 0.0021
Echinococcus granulosus tm gpcr rhodopsin 0.0021 0.0067 0.0033
Schistosoma mansoni sphingoid long chain base kinase 0.0616 0.6232 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0067 0.0021
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0248 0.0325
Onchocerca volvulus 0.0021 0.0067 0.0055
Onchocerca volvulus 0.0021 0.0067 0.0055
Loa Loa (eye worm) hypothetical protein 0.0026 0.0115 0.0156
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0022 0.0076 0.003
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0021 0.0067 0.0021
Loa Loa (eye worm) neuropeptide F receptor 0.0021 0.0067 0.0091
Brugia malayi Ceramide kinase 0.0024 0.0094 0.0127
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0022 0.0076 0.0103
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0321 0.0434
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0022 0.0076 0.0103
Brugia malayi G-protein coupled receptor 0.0021 0.0067 0.0091
Loa Loa (eye worm) beta-lactamase 0.0039 0.0248 0.0335
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0026 0.0115 0.0156
Echinococcus multilocularis g-protein coupled receptor 0.0021 0.0067 0.0021
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0091
Toxoplasma gondii hypothetical protein 0.0065 0.0518 1
Echinococcus granulosus sodium and chloride dependent glycine 0.0065 0.0518 0.0761
Leishmania major diacylglycerol kinase, putative 0.0024 0.0094 0.0098
Onchocerca volvulus Neuropeptide F receptor homolog 0.0021 0.0067 0.0055
Brugia malayi putative neuropeptide receptor 0.0021 0.0067 0.0091
Schistosoma mansoni hypothetical protein 0.0048 0.0338 0.0471
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0117 0.1059 0.1636
Onchocerca volvulus 0.0024 0.0094 0.0125
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0091
Loa Loa (eye worm) hypothetical protein 0.0372 0.3698 0.5008
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0021 0.0067 0.0033
Brugia malayi MH2 domain containing protein 0.0118 0.1066 0.1444
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0091
Brugia malayi Dopamine receptor 0.0021 0.0067 0.0091
Brugia malayi G-protein coupled receptor 0.0021 0.0067 0.0091
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0022 0.0076 0.0103
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0024 0.0094 0.0047
Echinococcus multilocularis sphingosine kinase 1 0.0616 0.6232 0.6215
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0065 0.0518 0.0701
Echinococcus granulosus neuropeptide Y receptor 0.0021 0.0067 0.0033
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0338 0.0457
Onchocerca volvulus 0.0065 0.0518 0.1252
Onchocerca volvulus 0.0021 0.0067 0.0055
Schistosoma mansoni histamine h1 receptor 0.0021 0.0067 0.0033
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0338 0.0471
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0021 0.0067 0.0021
Mycobacterium ulcerans hypothetical protein 0.0039 0.0248 0.0251
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0117 0.1059 0.1636
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0021 0.0067 0.0091
Onchocerca volvulus 0.0022 0.0076 0.0079
Leishmania major hypothetical protein, conserved 0.0024 0.0094 0.0098
Onchocerca volvulus Ceramide kinase 1 homolog 0.0024 0.0094 0.0125
Onchocerca volvulus 0.0021 0.0067 0.0055
Entamoeba histolytica hypothetical protein, conserved 0.0616 0.6232 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0347 0.0469
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0193 0.6487
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0091
Echinococcus multilocularis G protein coupled receptor 139 0.0021 0.0067 0.0021
Loa Loa (eye worm) hypothetical protein 0.0022 0.0076 0.0103
Loa Loa (eye worm) GABA receptor subunit 0.0026 0.0115 0.0156
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0091
Brugia malayi Serotonin receptor 0.0021 0.0067 0.0091
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0321 0.0443
Loa Loa (eye worm) hypothetical protein 0.0026 0.0115 0.0156
Echinococcus multilocularis neuropeptide FF receptor 2 0.0021 0.0067 0.0021
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0021 0.0067 0.0033
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0321 0.0443
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0091
Schistosoma mansoni amine GPCR 0.0021 0.0067 0.0033
Plasmodium falciparum diacylglycerol kinase, putative 0.0024 0.0094 0.1001
Schistosoma mansoni hypothetical protein 0.0048 0.0338 0.0471
Schistosoma mansoni nAChR subunit 0.0022 0.0076 0.0048
Schistosoma mansoni lamin 0.0028 0.0134 0.0142
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0048 0.0347 0.0485
Loa Loa (eye worm) hypothetical protein 0.0103 0.091 0.1232
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0091
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0207 0.0185
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0067 0.0033
Trypanosoma brucei C-8 sterol isomerase, putative 0.0727 0.7384 1
Onchocerca volvulus 0.0048 0.0347 0.0798
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0021 0.0067 0.0033
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0048 0.0347 0.0485
Loa Loa (eye worm) hypothetical protein 0.0039 0.0248 0.0335
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0048 0.0347 0.0485
Brugia malayi Tachykinin-like peptides receptor 99D 0.0021 0.0067 0.0091
Brugia malayi G protein-coupled receptor F59B2.13 0.0021 0.0067 0.0091
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0382 0.3807 0.6079
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0067 0.0033
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0021 0.0067 0.0033
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0021 0.0067 0.0055
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0091
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0024 0.0094 0.0076
Onchocerca volvulus 0.0021 0.0067 0.0055
Brugia malayi ORL1-like opioid receptor 0.0021 0.0067 0.0091
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0022 0.0076 0.0048
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0091
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0067 0.0021
Trichomonas vaginalis esterase, putative 0.0039 0.0248 1
Loa Loa (eye worm) hypothetical protein 0.0616 0.6232 0.844
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0048 0.0347 0.0485
Brugia malayi hypothetical protein 0.0021 0.0067 0.0091
Onchocerca volvulus 0.0021 0.0067 0.0055
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0024 0.0094 0.0127
Echinococcus multilocularis lamin dm0 0.0028 0.0134 0.0088
Schistosoma mansoni biogenic amine receptor 0.0021 0.0067 0.0033
Mycobacterium tuberculosis Conserved protein 0.0039 0.0248 0.0251
Echinococcus granulosus sex peptide receptor 0.0021 0.0067 0.0033
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0048 0.0347 0.0485
Loa Loa (eye worm) hypothetical protein 0.0048 0.0338 0.0457
Schistosoma mansoni neuropeptide F-like receptor 0.0021 0.0067 0.0033
Brugia malayi AKH receptor 0.0021 0.0067 0.0091
Loa Loa (eye worm) hypothetical protein 0.0048 0.0347 0.0469
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0022 0.0076 0.0103
Echinococcus multilocularis nAChR subunit 0.0048 0.0347 0.0301
Schistosoma mansoni neuropeptide receptor 0.0021 0.0067 0.0033
Echinococcus multilocularis neuropeptide Y receptor 0.0021 0.0067 0.0021
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0021 0.0067 0.0033
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0252 0.0333
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0091
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0248 0.0251
Mycobacterium ulcerans lipase LipD 0.0039 0.0248 0.0251
Schistosoma mansoni amine GPCR 0.0021 0.0067 0.0033
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0048 0.0347 0.0485
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0021 0.0067 0.0021
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0091
Echinococcus granulosus tachykinin peptides receptor 99D 0.0021 0.0067 0.0033
Schistosoma mansoni vesicular amine transporter 0.0553 0.5579 0.8943
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0067 0.0021
Echinococcus granulosus Diacylglycerol kinase theta 0.0024 0.0094 0.0076
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0021 0.0067 0.0033
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0248 0.2417 0.3785
Schistosoma mansoni growth hormone secretagogue receptor 0.0021 0.0067 0.0033
Brugia malayi Cation transporter family protein 0.0048 0.0347 0.0469
Echinococcus multilocularis lamin 0.0028 0.0134 0.0088
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0727 0.7384 1
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0248 0.0251
Echinococcus granulosus g protein coupled receptor 0.0021 0.0067 0.0033
Loa Loa (eye worm) hypothetical protein 0.0048 0.0347 0.0469
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0091
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0134 0.0182
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0022 0.0076 0.0103
Schistosoma mansoni biogenic amine (5HT) receptor 0.0021 0.0067 0.0033
Echinococcus multilocularis ceramide kinase 0.0024 0.0094 0.0047
Mycobacterium ulcerans beta-lactamase 0.0039 0.0248 0.0251
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0067 0.0033
Brugia malayi sulfakinin receptor protein 0.0021 0.0067 0.0091
Schistosoma mansoni lamin 0.0028 0.0134 0.0142
Brugia malayi PAS domain containing protein 0.0047 0.0334 0.0453
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0091
Loa Loa (eye worm) hypothetical protein 0.0048 0.0347 0.0469
Echinococcus granulosus neuropeptide receptor 0.0021 0.0067 0.0033
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0091
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0048 0.0347 0.0469
Schistosoma mansoni hypothetical protein 0.0523 0.527 0.8445
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0048 0.0347 0.0469
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0091
Schistosoma mansoni diacylglycerol kinase theta 0.0024 0.0094 0.0076
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0065 0.0518 0.0761
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0091
Schistosoma mansoni neurotransmitter gated ion channel 0.0022 0.0076 0.0048
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0021 0.0067 0.0091
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0048 0.0347 0.0485
Echinococcus multilocularis serotonin receptor 0.0021 0.0067 0.0021
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0067 0.0021
Loa Loa (eye worm) hypothetical protein 0.0022 0.0076 0.0103
Echinococcus granulosus 7tm_1 domain containing protein 0.0021 0.0067 0.0033
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0022 0.0076 0.003
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0091
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0091
Brugia malayi diacylglycerol kinase 0.0024 0.0094 0.0127
Plasmodium falciparum diacylglycerol kinase, putative 0.0024 0.0094 0.1001
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0248 0.0335
Onchocerca volvulus 0.0048 0.0347 0.0798
Loa Loa (eye worm) G-protein coupled receptor 0.0021 0.0067 0.0091
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0048 0.0347 0.0469
Brugia malayi hypothetical protein 0.0021 0.0067 0.0091
Loa Loa (eye worm) hypothetical protein 0.0022 0.0076 0.0103
Mycobacterium tuberculosis Conserved protein 0.0616 0.6232 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0063
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.041 0.0365
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0091
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0248 0.0251
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0065 0.0518 0.0701
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0021 0.0067 0.0021
Echinococcus granulosus 7TM GPCR rhodopsin 0.0021 0.0067 0.0033
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0021 0.0067 0.0033
Loa Loa (eye worm) hypothetical protein 0.0028 0.0134 0.0182
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0338 0.0293
Leishmania major hypothetical protein, conserved 0.0024 0.0094 0.0098
Echinococcus multilocularis neuropeptide receptor A26 0.0021 0.0067 0.0021
Brugia malayi hypothetical protein 0.0021 0.0067 0.0091
Loa Loa (eye worm) hypothetical protein 0.0382 0.3807 0.5156
Loa Loa (eye worm) diacylglycerol kinase 2 0.0024 0.0094 0.0127
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0021 0.0067 0.0033
Onchocerca volvulus 0.0021 0.0067 0.0055
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.0218 0.0172
Onchocerca volvulus 0.0021 0.0067 0.0055
Echinococcus granulosus alpha 1A adrenergic receptor 0.0021 0.0067 0.0033
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0248 0.0211
Onchocerca volvulus 0.0028 0.0134 0.0234
Brugia malayi beta-lactamase 0.0039 0.0248 0.0335
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0067 0.0033
Echinococcus granulosus tm gpcr rhodopsin 0.0021 0.0067 0.0033
Echinococcus granulosus glycine receptor subunit alpha 1 0.0048 0.0347 0.0485
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0021 0.0067 0.0091
Loa Loa (eye worm) TYRA-2 protein 0.0021 0.0067 0.0091
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0021 0.0067 0.0021
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0065 0.0518 0.0761
Schistosoma mansoni hypothetical protein 0.0021 0.0067 0.0033
Schistosoma mansoni opsin-like receptor 0.0021 0.0067 0.0033
Mycobacterium tuberculosis Conserved protein 0.0039 0.0248 0.0251
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0022 0.0076 0.003
Loa Loa (eye worm) hypothetical protein 0.0027 0.0129 0.0175
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0048 0.0347 0.0301
Loa Loa (eye worm) hypothetical protein 0.015 0.1403 0.1899
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0321 0.0275
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.1066 0.1444
Schistosoma mansoni hypothetical protein 0.0103 0.091 0.1395
Toxoplasma gondii hypothetical protein 0.0065 0.0518 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0115 0.0156
Echinococcus granulosus neuropeptide receptor A26 0.0021 0.0067 0.0033
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0065 0.0518 0.5
Echinococcus granulosus dro:myosuppressin receptor 0.0021 0.0067 0.0033
Loa Loa (eye worm) hypothetical protein 0.0382 0.3807 0.5156
Schistosoma mansoni neurotransmitter gated ion channel 0.0022 0.0076 0.0048
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0021 0.0067 0.0021
Brugia malayi Serotonin receptor 0.0021 0.0067 0.0091
Brugia malayi Eye-specific diacylglycerol kinase 0.0024 0.0094 0.0127
Echinococcus multilocularis sodium and chloride dependent glycine 0.0065 0.0518 0.0473
Schistosoma mansoni biogenic amine (5HT) receptor 0.0021 0.0067 0.0033
Leishmania major sphingosine kinase A, B, putative 0.0024 0.0094 0.0098
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0091
Schistosoma mansoni amine GPCR 0.0021 0.0067 0.0033
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0021 0.0067 0.0021
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0021 0.0067 0.0033
Onchocerca volvulus 0.0022 0.0076 0.0079
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0091
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0026 0.0115 0.0111
Echinococcus multilocularis neuropeptides capa receptor 0.0021 0.0067 0.0021
Echinococcus granulosus g protein coupled receptor 0.0021 0.0067 0.0033
Schistosoma mansoni biogenic amine receptor 0.0021 0.0067 0.0033
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0022 0.0076 0.0103
Schistosoma mansoni neuropeptide f receptor 76f 0.0021 0.0067 0.0033
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0048 0.0347 0.0485
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0048 0.0347 0.0301
Schistosoma mansoni sphingosine kinase A B 0.0616 0.6232 1
Schistosoma mansoni opsin-like receptor 0.0021 0.0067 0.0033
Echinococcus granulosus nAChR subunit 0.0048 0.0347 0.0485
Brugia malayi latrophilin 2 splice variant baaae 0.0103 0.091 0.1232
Schistosoma mansoni nAChR subunit 0.0022 0.0076 0.0048
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0024 0.0094 0.0076
Schistosoma mansoni myosin xvIII 0.0021 0.0067 0.0033
Schistosoma mansoni nAChR subunit 0.0048 0.0347 0.0485
Echinococcus multilocularis allatostatin A receptor 0.0021 0.0067 0.0021
Brugia malayi Melatonin receptor type 1A 0.0021 0.0067 0.0091
Brugia malayi hypothetical protein 0.0021 0.0067 0.0091
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0021 0.0067 0.0033
Brugia malayi Dopamine receptor protein 1 0.0021 0.0067 0.0091
Echinococcus granulosus intermediate filament protein 0.0028 0.0134 0.0142
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0338 0.0457
Loa Loa (eye worm) hypothetical protein 0.0065 0.0518 0.0701
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0021 0.0067 0.0033
Loa Loa (eye worm) hypothetical protein 0.0024 0.0094 0.0127
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0091
Brugia malayi hypothetical protein 0.0065 0.0518 0.0701
Loa Loa (eye worm) hypothetical protein 0.0022 0.0076 0.0103
Echinococcus granulosus lamin 0.0028 0.0134 0.0142
Echinococcus multilocularis dro:myosuppressin receptor 0.0021 0.0067 0.0021
Brugia malayi hypothetical protein 0.0019 0.0047 0.0063
Loa Loa (eye worm) hypothetical protein 0.0158 0.1487 0.2013
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0067 0.0033
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0065 0.0518 0.0761
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0091
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0022 0.0076 0.0103
Loa Loa (eye worm) G-protein coupled receptor 0.0021 0.0067 0.0091
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0091
Brugia malayi hypothetical protein 0.0019 0.0047 0.0063
Onchocerca volvulus 0.0048 0.0347 0.0798
Loa Loa (eye worm) neuropeptide F receptor 0.0021 0.0067 0.0091
Echinococcus multilocularis neuropeptide s receptor 0.0021 0.0067 0.0021
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0091
Onchocerca volvulus 0.0026 0.0115 0.0182
Brugia malayi hypothetical protein 0.0021 0.0067 0.0091
Schistosoma mansoni adenoreceptor 0.0021 0.0067 0.0033
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0248 1
Schistosoma mansoni sodium-dependent amino acid transporter 0.0065 0.0518 0.0761
Onchocerca volvulus 0.0039 0.0248 0.0534
Loa Loa (eye worm) hypothetical protein 0.0117 0.1059 0.1434
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0091
Brugia malayi beta-lactamase family protein 0.0039 0.0248 0.0335
Plasmodium vivax diacylglycerol kinase, putative 0.0024 0.0094 0.1001
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0091
Echinococcus granulosus neuropeptide Y receptor 0.0021 0.0067 0.0033
Echinococcus granulosus lamin dm0 0.0028 0.0134 0.0142
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0067 0.0033
Schistosoma mansoni lipoxygenase 0.0054 0.041 0.0587
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0065 0.0518 0.0473
Loa Loa (eye worm) acetylcholine receptor protein 0.0022 0.0076 0.0103
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0048 0.0347 0.0485
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0338 0.0457
Loa Loa (eye worm) hypoxia-induced factor 1 0.0146 0.136 0.1841
Onchocerca volvulus 0.0065 0.0518 0.1252
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0067 0.0021
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0382 0.3807 0.5156
Brugia malayi Calcitonin receptor-like protein seb-1 0.015 0.1403 0.1899
Plasmodium falciparum transporter, putative 0.0065 0.0518 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0347 0.0469
Echinococcus multilocularis glycine receptor subunit beta 0.0048 0.0347 0.0301
Mycobacterium tuberculosis Conserved protein 0.0039 0.0248 0.0251
Loa Loa (eye worm) hypothetical protein 0.0039 0.0248 0.0335
Brugia malayi hypothetical protein 0.0021 0.0067 0.0091
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0091
Brugia malayi hypothetical protein 0.0021 0.0067 0.0091
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0067 0.0033
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0065 0.0518 0.0761
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0067 0.0021
Loa Loa (eye worm) hypothetical protein 0.0024 0.0094 0.0127
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0021 0.0067 0.0033
Echinococcus multilocularis synaptic vesicular amine transporter 0.0553 0.5579 0.5558
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0321 0.0443
Schistosoma mansoni neuropeptide receptor 0.0021 0.0067 0.0033
Echinococcus granulosus Diacylglycerol kinase zeta 0.0024 0.0094 0.0076
Echinococcus multilocularis GPCR, family 2 0.0048 0.0338 0.0293
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0022 0.0076 0.0048
Loa Loa (eye worm) hypothetical protein 0.0031 0.0169 0.0229
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0048 0.0347 0.0469
Schistosoma mansoni diacylglycerol kinase theta 0.0024 0.0094 0.0076
Loa Loa (eye worm) hypothetical protein 0.0048 0.0347 0.0469
Loa Loa (eye worm) ACC-1 protein 0.0048 0.0347 0.0469
Echinococcus granulosus GPCR family 2 0.0048 0.0338 0.0471
Brugia malayi hypothetical protein 0.0021 0.0067 0.0091
Mycobacterium ulcerans hypothetical protein 0.0616 0.6232 1
Schistosoma mansoni biogenic amine receptor 0.0021 0.0067 0.0033
Echinococcus granulosus neuropeptides capa receptor 0.0021 0.0067 0.0033
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0026 0.0115 0.0156
Schistosoma mansoni hypothetical protein 0.0523 0.527 0.8445
Echinococcus granulosus allatostatin A receptor 0.0021 0.0067 0.0033
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0067 0.0033
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0321 0.0275
Schistosoma mansoni amine GPCR 0.0021 0.0067 0.0033
Brugia malayi Doublecortin family protein 0.0019 0.0047 0.0063
Brugia malayi RE15519p 0.0021 0.0067 0.0091
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0338 0.0293
Brugia malayi diacylglycerol kinase 0.0024 0.0094 0.0127
Schistosoma mansoni neurotransmitter gated ion channel 0.0026 0.0115 0.0111
Echinococcus multilocularis sex peptide receptor 0.0021 0.0067 0.0021
Echinococcus granulosus synaptic vesicular amine transporter 0.0553 0.5579 0.8943
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0048 0.0347 0.0469
Loa Loa (eye worm) hypothetical protein 0.0048 0.0347 0.0469
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0021 0.0067 0.0091
Plasmodium vivax hypothetical protein, conserved 0.0065 0.0518 1
Entamoeba histolytica hypothetical protein 0.0026 0.0115 0.0035
Loa Loa (eye worm) hypothetical protein 0.0048 0.0347 0.0469
Echinococcus multilocularis G-protein coupled receptor, putative 0.0021 0.0067 0.0021
Loa Loa (eye worm) hypothetical protein 0.0022 0.0076 0.0103
Leishmania major hypothetical protein, conserved 0.0039 0.0248 0.0307
Echinococcus multilocularis fmrfamide receptor 0.0021 0.0067 0.0021
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0048 0.0347 0.0469
Onchocerca volvulus 0.0026 0.0115 0.0182
Brugia malayi intermediate filament protein 0.0028 0.0134 0.0182
Brugia malayi neuropeptide F receptor 0.0021 0.0067 0.0091
Echinococcus multilocularis musashi 0.0028 0.0134 0.0088
Brugia malayi beta-lactamase family protein 0.0039 0.0248 0.0335
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0134 0.0182
Echinococcus multilocularis Diacylglycerol kinase theta 0.0024 0.0094 0.0047
Echinococcus multilocularis g protein coupled receptor 0.0021 0.0067 0.0021
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0727 0.7384 1
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0207 0.0161
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0248 0.0251
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0067 0.0033
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0048 0.0347 0.0469
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0067 0.0033
Loa Loa (eye worm) hypothetical protein 0.0022 0.0076 0.0103
Schistosoma mansoni nAChR subunit 0.0048 0.0347 0.0485
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0067 0.0021
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0065 0.0518 0.0761
Schistosoma mansoni hypothetical protein 0.0021 0.0067 0.0033
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0048 0.0347 0.0469
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.0218 0.0277
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0065 0.0518 0.0761
Echinococcus granulosus g protein coupled receptor 0.0021 0.0067 0.0033
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0048 0.0347 0.0301
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0065 0.0518 0.0761
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0048 0.0347 0.0301
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0091
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0065 0.0518 0.0761
Onchocerca volvulus Putative nachr subunit 0.0048 0.0347 0.0798
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0021 0.0067 0.0021
Echinococcus granulosus ceramide kinase 0.0024 0.0094 0.0076
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0021 0.0067 0.0033
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0067 0.0033
Loa Loa (eye worm) hypothetical protein 0.0048 0.0347 0.0469
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0207 0.028
Schistosoma mansoni amine GPCR 0.0021 0.0067 0.0033
Brugia malayi hypothetical protein 0.0021 0.0067 0.0091
Brugia malayi putative neuropeptide receptor NPR1 0.0021 0.0067 0.0091
Brugia malayi hypothetical protein 0.0021 0.0067 0.0091
Onchocerca volvulus 0.0065 0.0518 0.1252
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0048 0.0347 0.0301
Brugia malayi hypothetical protein 0.0022 0.0076 0.0103
Brugia malayi hypoxia-induced factor 1 0.0146 0.136 0.1841
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0248 0.5
Loa Loa (eye worm) hypothetical protein 0.0048 0.0347 0.0469
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0065 0.0518 0.0761
Brugia malayi hypothetical protein 0.0024 0.0094 0.0127
Loa Loa (eye worm) hypothetical protein 0.0048 0.0347 0.0469
Echinococcus granulosus glycine receptor subunit beta 0.0048 0.0347 0.0485
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0048 0.0347 0.0485
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0065 0.0518 1
Echinococcus granulosus neuropeptide receptor 0.0021 0.0067 0.0033
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0048 0.0347 0.0469
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0091
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0248 0.0251
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.1066 0.1444
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0091
Schistosoma mansoni opsin-like receptor 0.0021 0.0067 0.0033
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0248 0.0251
Echinococcus multilocularis neuropeptide receptor 0.0021 0.0067 0.0021
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0022 0.0076 0.0103
Leishmania major diacylglycerol kinase-like protein 0.0024 0.0094 0.0098
Loa Loa (eye worm) hypothetical protein 0.0727 0.7384 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0021 0.0067 0.0033
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0248 0.0335
Loa Loa (eye worm) melatonin receptor type 1A 0.0021 0.0067 0.0091
Onchocerca volvulus 0.0021 0.0067 0.0055
Schistosoma mansoni hypothetical protein 0.0021 0.0067 0.0033
Onchocerca volvulus 0.0117 0.1059 0.2691
Loa Loa (eye worm) hypothetical protein 0.0039 0.0248 0.0335
Loa Loa (eye worm) hypothetical protein 0.0095 0.0827 0.112
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0248 0.0325
Echinococcus multilocularis neuropeptides capa receptor 0.0021 0.0067 0.0021
Loa Loa (eye worm) hypothetical protein 0.0382 0.3807 0.5156
Loa Loa (eye worm) hypothetical protein 0.0048 0.0347 0.0469
Brugia malayi follicle stimulating hormone receptor 0.0021 0.0067 0.0091
Onchocerca volvulus 0.0021 0.0067 0.0055
Onchocerca volvulus 0.0117 0.1059 0.2691
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0091
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0091
Brugia malayi Cation transporter family protein 0.0117 0.1059 0.1434
Schistosoma mansoni nAChR subunit 0.0048 0.0347 0.0485
Loa Loa (eye worm) hypothetical protein 0.0048 0.0347 0.0469
Schistosoma mansoni sodium/chloride dependent transporter 0.0065 0.0518 0.0761
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0021 0.0067 0.0021
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0091
Echinococcus granulosus hypothetical protein 0.0021 0.0067 0.0033
Onchocerca volvulus 0.0382 0.3807 1
Brugia malayi larval opioid receptor 0.0021 0.0067 0.0091
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0021 0.0067 0.0033
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0048 0.0347 0.0469
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0048 0.0347 0.0485
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0021 0.0067 0.0091
Echinococcus multilocularis serotonin receptor 0.0021 0.0067 0.0021
Loa Loa (eye worm) hypothetical protein 0.0022 0.0076 0.0103
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0048 0.0347 0.0469
Loa Loa (eye worm) hypothetical protein 0.0117 0.1059 0.1434
Plasmodium vivax diacylglycerol kinase, putative 0.0024 0.0094 0.1001
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0021 0.0067 0.0091
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0091
Echinococcus multilocularis g protein coupled receptor 0.0021 0.0067 0.0021
Mycobacterium leprae Probable lipase LipE 0.0039 0.0248 0.5
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0024 0.0094 0.0076
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0021 0.0067 0.0091
Echinococcus granulosus geminin 0.0523 0.527 0.8445
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0021 0.0067 0.0033
Loa Loa (eye worm) ACC-1 protein 0.0048 0.0347 0.0469
Echinococcus granulosus peptide allatostatin:somatostatin 0.0021 0.0067 0.0033
Echinococcus granulosus single minded 2 0.0038 0.0241 0.0315
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0048 0.0347 0.0469
Loa Loa (eye worm) hypothetical protein 0.0048 0.0347 0.0469
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0321 0.0443
Toxoplasma gondii ABC1 family protein 0.0039 0.0248 0.3629
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0048 0.0347 0.0469
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0091
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0065 0.0518 0.0473
Loa Loa (eye worm) hypothetical protein 0.0065 0.0518 0.0701
Schistosoma mansoni sodium/chloride dependent transporter 0.0382 0.3807 0.6079
Treponema pallidum sodium- and chloride- dependent transporter 0.0382 0.3807 0.5
Brugia malayi Cation transporter family protein 0.0048 0.0347 0.0469
Schistosoma mansoni single-minded 0.0047 0.0334 0.0465
Brugia malayi G protein-coupled receptor 0.0021 0.0067 0.0091
Echinococcus granulosus sphingosine kinase 1 0.0616 0.6232 1
Echinococcus granulosus somatostatin receptor 0.0021 0.0067 0.0033
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0021 0.0067 0.0033
Schistosoma mansoni neuropeptide receptor 0.0021 0.0067 0.0033
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0048 0.0347 0.0301
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0065 0.0518 0.0701
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0067 0.0021
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0065 0.0518 0.0701
Echinococcus granulosus g-protein coupled receptor 0.0021 0.0067 0.0033
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0036 0.0218 0.0295
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0065 0.0518 0.0761
Loa Loa (eye worm) hypothetical protein 0.0026 0.0115 0.0156
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0065 0.0518 0.0761
Echinococcus granulosus fmrfamide receptor 0.0021 0.0067 0.0033
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0091
Echinococcus multilocularis sodium and chloride dependent glycine 0.0065 0.0518 0.0473
Echinococcus multilocularis neuropeptide Y receptor 0.0021 0.0067 0.0021
Loa Loa (eye worm) hypothetical protein 0.0022 0.0076 0.0103
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0248 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0076 0.0103
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0048 0.0347 0.0301
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0252 0.0333
Onchocerca volvulus 0.0021 0.0067 0.0055
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0048 0.0347 0.0469
Loa Loa (eye worm) hypothetical protein 0.0026 0.0115 0.0156
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0248 0.0211
Onchocerca volvulus 0.0021 0.0067 0.0055
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0091
Echinococcus granulosus glycine receptor subunit alpha 1 0.0048 0.0347 0.0485
Echinococcus multilocularis serotonin transporter 0.0382 0.3807 0.3778
Onchocerca volvulus 0.0021 0.0067 0.0055
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0048 0.0347 0.0485
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0021 0.0067 0.0021
Schistosoma mansoni hypothetical protein 0.0048 0.0338 0.0471
Loa Loa (eye worm) hypothetical protein 0.0022 0.0076 0.0103
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0048 0.0347 0.0469
Echinococcus granulosus serotonin receptor 0.0021 0.0067 0.0033
Loa Loa (eye worm) solute carrier family 6 member 4 0.0382 0.3807 0.5156
Loa Loa (eye worm) hypothetical protein 0.0039 0.0248 0.0335
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0048 0.0347 0.0469
Echinococcus multilocularis somatostatin receptor 0.0021 0.0067 0.0021
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0067 0.0033
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0091
Onchocerca volvulus 0.0021 0.0067 0.0055
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0091
Echinococcus granulosus glycine receptor subunit beta 0.0048 0.0347 0.0485
Echinococcus granulosus tm gpcr rhodopsin 0.0021 0.0067 0.0033
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0091
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0248 0.0211
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0067 0.0033
Echinococcus multilocularis nAChR subunit 0.0026 0.0115 0.0069
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0067 0.0033
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0021 0.0067 0.0033
Brugia malayi hypothetical protein 0.0022 0.0076 0.0103
Echinococcus granulosus sodium and chloride dependent glycine 0.0065 0.0518 0.0761
Loa Loa (eye worm) hypothetical protein 0.0022 0.0076 0.0103
Echinococcus granulosus biogenic amine 5HT receptor 0.0021 0.0067 0.0033
Loa Loa (eye worm) ceramide kinase 0.0024 0.0094 0.0127
Schistosoma mansoni neuropeptide receptor 0.0021 0.0067 0.0033
Schistosoma mansoni acetylcholine receptor-related 0.0022 0.0076 0.0048
Echinococcus granulosus glycine receptor subunit alpha 1 0.0048 0.0347 0.0485
Echinococcus multilocularis fmrfamide receptor 0.0021 0.0067 0.0021
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0048 0.0347 0.0301
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0091
Echinococcus granulosus serotonin transporter 0.0382 0.3807 0.6079
Schistosoma mansoni neuropeptide F-like receptor 0.0021 0.0067 0.0033
Brugia malayi excitatory GABA receptor EXP-1A 0.0048 0.0347 0.0469
Echinococcus granulosus nAChR subunit 0.0026 0.0115 0.0111
Onchocerca volvulus 0.0021 0.0067 0.0055
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0026 0.0115 0.0156
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0026 0.0115 0.0111
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0024 0.0094 0.0047
Schistosoma mansoni alpha-1 adrenergic receptor 0.0021 0.0067 0.0033
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0048 0.0347 0.0469
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0065 0.0518 0.0473
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0321 0.0434
Schistosoma mansoni nAChR subunit 0.0048 0.0347 0.0485
Echinococcus granulosus orexin receptor type 2 0.0021 0.0067 0.0033
Loa Loa (eye worm) hypothetical protein 0.0039 0.0248 0.0335
Loa Loa (eye worm) hypothetical protein 0.0048 0.0347 0.0469
Schistosoma mansoni sodium/chloride dependent transporter 0.0065 0.0518 0.0761

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.1577 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 37.933 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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