TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 346.406 | Formula: C19H14N4OS
H donors: 2 H acceptors: 2 LogP: 4.57 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1sc2c(c1N)cccn2)N/N=C/c1cccc2c1cccc2
InChi: 1S/C19H14N4OS/c20-16-15-9-4-10-21-19(15)25-17(16)18(24)23-22-11-13-7-3-6-12-5-1-2-8-14(12)13/h1-11H,20H2,(H,23,24)/b22-11+
InChiKey: ZPRGXCVIVGKQTM-SSDVNMTOSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	SRC proto-oncogene, non-receptor tyrosine kinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K08892 fyn-related kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	protein-tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FGR, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Srms	Get druggable targets OG5_127750	All targets in OG5_127750
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase Yrk, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Lyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0013	0.0546	0.191
Schistosoma mansoni	hypothetical protein	0.0004	0.0086	0.0342
Echinococcus multilocularis	breast cancer anti estrogen resistance protein	0.0004	0.0086	0.0381
Schistosoma mansoni	signal transduction protein lnk-related	0.0005	0.0093	0.0366
Leishmania major	telomerase reverse transcriptase, putative	0.0052	0.2623	1
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0005	0.0093	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0167	0.0356
Schistosoma mansoni	nck2/grb4	0.0009	0.0328	0.1299
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0086	0.0184
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0045	0.2271	1
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0167	0.0356
Schistosoma mansoni	cell polarity protein	0.0004	0.0086	0.0342
Loa Loa (eye worm)	STAT protein	0.0005	0.0093	0.0197
Brugia malayi	Variant SH3 domain containing protein	0.0004	0.0086	0.012
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0206	0.0439
Schistosoma mansoni	run and tbc1 domain containing	0.0004	0.0086	0.0342
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.0004	0.0056	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0328	0.0699
Schistosoma mansoni	growth factor receptor-bound protein	0.0009	0.0328	0.1299
Loa Loa (eye worm)	SH2 domain-containing protein	0.0005	0.0093	0.0197
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0036	0.1793	0.7895
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0006	0.0167	0.0232
Echinococcus granulosus	intersectin 2	0.0004	0.0086	0.0381
Echinococcus granulosus	FTZ F1 alpha	0.0006	0.0167	0.0737
Echinococcus multilocularis		0.0005	0.0093	0.0407
Echinococcus granulosus	hematopoietic lineage cell specific protein	0.0004	0.0086	0.0381
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0005	0.0093	0.0366
Brugia malayi	Tyrosine-protein kinase abl-1	0.001	0.0396	0.0548
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0005	0.0093	0.0407
Schistosoma mansoni	tyrosine kinase	0.0006	0.016	0.0635
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0045	0.2271	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0006	0.0167	0.0232
Loa Loa (eye worm)	hypothetical protein	0.0003	0.0018	0.0038
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0005	0.0093	0.0407
Brugia malayi	Spectrin alpha chain	0.0004	0.0086	0.012
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0093	0.0197
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0013	0.0546	0.216
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0005	0.0093	0.0407
Trypanosoma brucei	telomerase reverse transcriptase	0.0052	0.2623	1
Onchocerca volvulus		0.0006	0.016	0.016
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0006	0.0167	0.0232
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0093	0.0197
Schistosoma mansoni	dynamin-associated protein	0.0004	0.0086	0.0342
Brugia malayi	nuclear receptor NHR-88	0.0006	0.0167	0.0232
Echinococcus granulosus	breast cancer anti estrogen resistance protein	0.0004	0.0086	0.0381
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0005	0.0093	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0247	0.0526
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0086	0.0184
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0006	0.0167	0.0356
Plasmodium vivax	telomerase reverse transcriptase, putative	0.0052	0.2623	1
Echinococcus multilocularis	FTZ F1 alpha	0.0006	0.0167	0.0737
Schistosoma mansoni	suppressor of cytokine signaling	0.0005	0.0093	0.0366
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0005	0.0093	0.0407
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0004	0.0086	0.0381
Echinococcus granulosus	tyrosine protein kinase shark	0.0006	0.016	0.0706
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0013	0.052	0.2292
Brugia malayi	Steroid receptor seven-up type 2	0.0006	0.0167	0.0232
Onchocerca volvulus	Bile acid receptor homolog	0.0006	0.0167	0.0167
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0005	0.0093	0.0407
Giardia lamblia	Telomerase catalytic subunit	0.0052	0.2623	1
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0005	0.0093	0.0407
Schistosoma mansoni	apoptosis stimulating of P53	0.0004	0.0086	0.0342
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0006	0.0167	0.0662
Echinococcus granulosus	tensin	0.0005	0.0093	0.0407
Echinococcus granulosus	nostrin	0.0004	0.0086	0.0381
Onchocerca volvulus		0.0013	0.0546	0.0546
Loa Loa (eye worm)	TK/ABL protein kinase	0.0006	0.016	0.0341
Loa Loa (eye worm)	SH2 domain-containing protein	0.0005	0.0093	0.0197
Schistosoma mansoni	tyrosine kinase	0.0045	0.2271	0.8983
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0009	0.0328	0.0699
Loa Loa (eye worm)	TK protein kinase	0.0036	0.1793	0.3815
Brugia malayi	SH2 domain containing protein	0.0006	0.016	0.0222
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0008	0.0287	0.0902
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0005	0.0093	0.0407
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0013	0.0546	0.216
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0093	0.0197
Echinococcus multilocularis	epidermal growth factor receptor kinase	0.0004	0.0086	0.0381
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0006	0.0183	0.0495
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0006	0.0167	0.0356
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0045	0.2271	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0045	0.2271	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0005	0.0093	0.0366
Toxoplasma gondii	RNA-directed DNA polymerase	0.0052	0.2623	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0005	0.0093	0.0128
Schistosoma mansoni	formin binding protein and related proteins	0.0004	0.0086	0.0342
Onchocerca volvulus		0.0006	0.016	0.016
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0045	0.2271	1
Loa Loa (eye worm)	hypothetical protein	0.0006	0.016	0.0341
Echinococcus granulosus	histone lysine methyltransferase setb	0.0013	0.0546	0.2404
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0086	0.0184
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0154	0.0611
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0167	0.0356
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0005	0.0093	0.0366
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0006	0.0167	0.0232
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0093	0.0197
Schistosoma mansoni	sh3-containing grb2-like protein 1 (endophilin II)	0.0004	0.0086	0.0342
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0006	0.0167	0.0737
Loa Loa (eye worm)	TK/FER protein kinase	0.0006	0.016	0.0341
Schistosoma mansoni	tensin	0.0005	0.0093	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0056	0.0119
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0005	0.0093	0.0128
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0006	0.0167	0.0662
Schistosoma mansoni	adapter molecule crk	0.0009	0.0328	0.1299
Onchocerca volvulus		0.0005	0.0093	0.0093
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0005	0.0093	0.0407
Echinococcus granulosus	c src tyrosine kinase	0.001	0.0396	0.1746
Echinococcus granulosus	tyrosine protein kinase Srms	0.0006	0.016	0.0706
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0004	0.0056	0.00000000036413
Echinococcus granulosus	fch and double sh3 domains protein 2	0.0004	0.0086	0.0381
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0006	0.0167	0.0232
Entamoeba histolytica	SH2 domain containing protein	0.0005	0.0093	0.0035
Echinococcus multilocularis	tensin	0.0005	0.0093	0.0407
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0006	0.0167	0.0232
Trypanosoma cruzi	telomerase reverse transcriptase, putative	0.0052	0.2623	1
Brugia malayi	Bloom's syndrome protein homolog	0.0009	0.0348	0.0481
Schistosoma mansoni	nuclear hormone receptor	0.0006	0.0167	0.0662
Brugia malayi	Variant SH3 domain containing protein	0.0009	0.0328	0.0454
Schistosoma mansoni	tyrosine kinase	0.0045	0.2271	0.8983
Schistosoma mansoni	hypothetical protein	0.0005	0.0093	0.0366
Brugia malayi	Protein kinase domain containing protein	0.0006	0.016	0.0222
Brugia malayi	hypothetical protein	0.0005	0.0093	0.0128
Entamoeba histolytica	protein kinase, putative	0.0036	0.1793	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0045	0.2271	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0005	0.0093	0.0197
Schistosoma mansoni	thyroid hormone receptor	0.0006	0.0167	0.0662
Brugia malayi	SH3 domain containing protein	0.0004	0.0086	0.012
Trichomonas vaginalis	DNA helicase recq1, putative	0.0009	0.0348	0.0494
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0546	0.1162
Brugia malayi	Nuclear hormone receptor-like 1	0.0003	0.0018	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0086	0.0184
Echinococcus multilocularis	SH2 motif	0.0005	0.0093	0.0407
Loa Loa (eye worm)	TK/FER protein kinase	0.0006	0.016	0.0341
Echinococcus granulosus	tyrosine kinase	0.0006	0.016	0.0706
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0006	0.0167	0.0662
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0045	0.2271	1
Loa Loa (eye worm)	hypothetical protein	0.0003	0.0018	0.0038
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0006	0.0167	0.0737
Loa Loa (eye worm)	TK/FER protein kinase	0.0006	0.016	0.0341
Loa Loa (eye worm)	TK/FER protein kinase	0.0006	0.016	0.0341
Loa Loa (eye worm)	hypothetical protein	0.0003	0.0018	0.0038
Schistosoma mansoni	SH2A	0.0005	0.0093	0.0366
Schistosoma mansoni	signal transducing adapter molecule (stam)	0.0004	0.0086	0.0342
Onchocerca volvulus		0.0005	0.0093	0.0093
Schistosoma mansoni	tensin	0.0005	0.0093	0.0366
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0006	0.016	0.0706
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0006	0.0167	0.0737
Echinococcus granulosus	expressed protein	0.0004	0.0086	0.0381
Brugia malayi	Variant SH3 domain containing protein	0.0004	0.0086	0.012
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0006	0.0167	0.0356
Schistosoma mansoni	tensin	0.0005	0.0093	0.0366
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0005	0.0093	0.0197
Echinococcus multilocularis	NCK adaptor protein	0.0009	0.0328	0.1446
Brugia malayi	Telomerase reverse transcriptase	0.0139	0.7228	1
Echinococcus granulosus	NCK adaptor protein	0.0009	0.0328	0.1446
Brugia malayi	Variant SH3 domain containing protein	0.0005	0.0093	0.0128
Schistosoma mansoni	Dab2-interacting protein-like	0.0004	0.0086	0.0342
Onchocerca volvulus		0.0104	0.537	0.537
Brugia malayi	protein-tyrosine kinase	0.0004	0.0086	0.012
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0005	0.0093	0.0407
Brugia malayi	Nuclear hormone receptor-like 1	0.0003	0.0018	0.0025
Onchocerca volvulus		0.0006	0.016	0.016
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0006	0.0167	0.0232
Echinococcus multilocularis	Spectrin alpha actinin	0.0004	0.0086	0.0381
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0006	0.016	0.0706
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0005	0.0093	0.0407
Loa Loa (eye worm)	TK/FER protein kinase	0.0006	0.016	0.0341
Loa Loa (eye worm)	protein-tyrosine kinase	0.0004	0.0086	0.0184
Echinococcus granulosus	tyrosine kinase	0.0041	0.2035	0.8961
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0093	0.0197
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0003	0.0018	0.0071
Onchocerca volvulus	Protein ultraspiracle homolog	0.0006	0.0167	0.0167
Schistosoma mansoni	vav2	0.0005	0.0093	0.0366
Loa Loa (eye worm)	TK/FER protein kinase	0.0006	0.016	0.0341
Loa Loa (eye worm)	TK/FER protein kinase	0.0006	0.016	0.0341
Plasmodium vivax	SET domain protein, putative	0.0013	0.0546	0.1475
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0045	0.2271	1
Trypanosoma brucei	RNA helicase, putative	0.005	0.2528	0.9627
Echinococcus multilocularis	c src tyrosine kinase	0.001	0.0396	0.1746
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0006	0.016	0.0433
Onchocerca volvulus		0.0004	0.0086	0.0086
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0009	0.0328	0.1446
Onchocerca volvulus	LIM and SH3 domain protein homolog	0.0004	0.0086	0.0086
Brugia malayi	Protein kinase domain containing protein	0.0006	0.016	0.0222
Brugia malayi	Nuclear hormone receptor-like 1	0.0006	0.0167	0.0232
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0005	0.0093	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0093	0.0197
Brugia malayi	SH2 domain containing protein	0.0005	0.0093	0.0128
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0041	0.2035	0.8961
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0013	0.0546	0.216
Echinococcus granulosus	SH2 motif	0.0005	0.0093	0.0407
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0006	0.0167	0.0167
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0041	0.2035	0.8961
Echinococcus granulosus	bloom syndrome protein	0.0009	0.0348	0.1531
Echinococcus multilocularis	ecdysone induced protein 78C	0.0006	0.0167	0.0737
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0005	0.0093	0.0128
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.001	0.0396	0.1746
Schistosoma mansoni	retinoic acid receptor RXR	0.0006	0.0167	0.0662
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0009	0.0328	0.1299
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0006	0.0167	0.0356
Loa Loa (eye worm)	TK protein kinase	0.0041	0.2035	0.433
Brugia malayi	Fibroblast growth factor family protein	0.0007	0.0206	0.0286
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.001	0.0396	0.1568
Brugia malayi	Fes/CIP4 homology domain containing protein	0.0004	0.0086	0.012
Echinococcus multilocularis	SH2 domain containing protein 7	0.0005	0.0093	0.0407
Giardia lamblia	Hypothetical protein	0.0007	0.0206	0.0587
Echinococcus multilocularis	bloom syndrome protein	0.0009	0.0348	0.1531
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0005	0.0093	0.0407
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0005	0.0093	0.0128
Loa Loa (eye worm)	TK/FER protein kinase	0.0006	0.016	0.0341
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0006	0.0167	0.0737
Schistosoma mansoni	eps8-related protein	0.0004	0.0086	0.0342
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0003	0.0018	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0086	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0093	0.0197
Brugia malayi	SH2 domain containing protein	0.0005	0.0093	0.0128
Brugia malayi	Myosin tail family protein	0.0004	0.0086	0.012
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0093	0.0197
Entamoeba histolytica	protein kinase, putative	0.0005	0.0093	0.0035
Brugia malayi	SH2 domain containing protein	0.0005	0.0093	0.0128
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0045	0.2271	1
Onchocerca volvulus		0.0006	0.016	0.016
Brugia malayi	Peripheral plasma membrane protein CASK	0.0004	0.0086	0.012
Schistosoma mansoni	tyrosine kinase	0.001	0.0396	0.1568
Echinococcus multilocularis	signal transduction protein lnk realted	0.0005	0.0093	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0093	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0086	0.0184
Schistosoma mansoni	RAR-like nuclear receptor	0.0006	0.0167	0.0662
Onchocerca volvulus		0.0005	0.0093	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0086	0.0184
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0006	0.0167	0.0737
Schistosoma mansoni	shc transforming protein	0.0005	0.0093	0.0366
Echinococcus granulosus	SH2 motif	0.0005	0.0093	0.0407
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0005	0.0116	0.0117
Echinococcus multilocularis	SH2 motif	0.0005	0.0093	0.0407
Echinococcus multilocularis	hematopoietic lineage cell specific protein	0.0004	0.0086	0.0381
Schistosoma mansoni	tensin-related	0.0005	0.0093	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0093	0.0197
Echinococcus granulosus	tyrosine protein kinase HCK	0.0036	0.1793	0.7895
Brugia malayi	Variant SH3 domain containing protein	0.0005	0.0093	0.0128
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0005	0.0093	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0167	0.0356
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0006	0.0167	0.0737
Echinococcus multilocularis	tyrosine protein kinase Abl	0.001	0.0396	0.1746
Loa Loa (eye worm)	hypothetical protein	0.0003	0.0018	0.0038
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0003	0.0018	0.0079
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0006	0.0167	0.0662
Schistosoma mansoni	coup transcription factor	0.0006	0.0167	0.0662
Echinococcus granulosus	rho guanine nucleotide exchange factor 7	0.0004	0.0086	0.0381
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0005	0.0093	0.0407
Onchocerca volvulus		0.0004	0.0086	0.0086
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0006	0.0167	0.0737
Brugia malayi	protein-tyrosine kinase	0.0041	0.2035	0.2816
Onchocerca volvulus		0.0006	0.0167	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0003	0.0018	0.0038
Echinococcus multilocularis	endophilin A3	0.0004	0.0086	0.0381
Loa Loa (eye worm)	thyroid receptor interactor	0.0004	0.0086	0.0184
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0004	0.0056	0.0077
Schistosoma mansoni	blooms syndrome DNA helicase	0.0007	0.0243	0.0962
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0091	0.47	1
Echinococcus multilocularis	intersectin 2	0.0004	0.0086	0.0381
Brugia malayi	Guanylate kinase family protein	0.0004	0.0086	0.012
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0003	0.0018	0.0071
Echinococcus granulosus	endophilin A3	0.0004	0.0086	0.0381
Echinococcus granulosus	slit robo rho gtpase activating protein 1	0.0004	0.0086	0.0381
Brugia malayi	SH2 domain containing protein	0.0005	0.0093	0.0128
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0005	0.0093	0.0093
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0045	0.2271	1
Brugia malayi	Variant SH3 domain containing protein	0.0004	0.0086	0.012
Loa Loa (eye worm)	RecQ helicase	0.0009	0.0348	0.074
Schistosoma mansoni	sorting nexin	0.0004	0.0086	0.0342
Onchocerca volvulus		0.0004	0.0086	0.0086
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.0004	0.0056	0.0245
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.001	0.0396	0.1746
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0006	0.0167	0.0737
Schistosoma mansoni	DNA helicase recq1	0.0004	0.0056	0.0221
Loa Loa (eye worm)	protein kinase C and casein kinase substrate in neurons protein 2	0.0004	0.0086	0.0184
Loa Loa (eye worm)	p53BP2	0.0004	0.0086	0.0184
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0006	0.016	0.0706
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0004	0.0086	0.0184
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0006	0.0167	0.0737
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0045	0.2271	1
Schistosoma mansoni	sorbin	0.0004	0.0086	0.0342
Echinococcus granulosus	epidermal growth factor receptor kinase	0.0004	0.0086	0.0381
Brugia malayi	Variant SH3 domain containing protein	0.0004	0.0086	0.012
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0005	0.0093	0.0035
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0004	0.0086	0.0342
Echinococcus multilocularis	expressed protein	0.0004	0.0086	0.0381
Echinococcus granulosus	SHC transforming protein 3	0.0005	0.0093	0.0407
Echinococcus multilocularis	rho guanine nucleotide exchange factor 7	0.0004	0.0086	0.0381
Echinococcus multilocularis	tyrosine protein kinase shark	0.0006	0.016	0.0706
Echinococcus multilocularis	SHC transforming protein 3	0.0005	0.0093	0.0407
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.0004	0.0056	0.0119
Trichomonas vaginalis	DNA helicase recq, putative	0.0009	0.0348	0.0494
Plasmodium falciparum	telomerase reverse transcriptase	0.0052	0.2623	1
Schistosoma mansoni	hypothetical protein	0.0004	0.0086	0.0342
Echinococcus granulosus	ecdysone induced protein 78C	0.0006	0.0167	0.0737
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0005	0.0093	0.0407
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0045	0.2271	1
Onchocerca volvulus		0.0005	0.0093	0.0093
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0041	0.2035	0.8961
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0013	0.0546	0.2404
Loa Loa (eye worm)	TK/FER protein kinase	0.0006	0.016	0.0341
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0006	0.0167	0.0737
Trypanosoma cruzi	telomerase reverse transcriptase, putative	0.0052	0.2623	1
Onchocerca volvulus		0.0004	0.0086	0.0086
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0009	0.0328	0.0699
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0006	0.0167	0.0356
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0005	0.0093	0.0093
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0006	0.0167	0.0737
Brugia malayi	nuclear receptor RXR	0.0003	0.0018	0.0025
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.0004	0.0056	0.0245
Brugia malayi	Protein kinase domain containing protein	0.0006	0.016	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0093	0.0197
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0004	0.0086	0.0381
Loa Loa (eye worm)	guanylate kinase	0.0004	0.0086	0.0184
Brugia malayi	nuclear hormone receptor	0.0006	0.0167	0.0232
Echinococcus granulosus	SH2 domain containing protein 7	0.0005	0.0093	0.0407
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0006	0.016	0.0706
Brugia malayi	hypothetical protein	0.0006	0.016	0.0222
Onchocerca volvulus		0.0006	0.016	0.016
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0006	0.0167	0.0232
Schistosoma mansoni	suppressor of cytokine signaling	0.0005	0.0093	0.0366
Brugia malayi	SH2 domain containing protein	0.0005	0.0093	0.0128
Schistosoma mansoni	thyroid hormone receptor	0.0006	0.0167	0.0662
Brugia malayi	Protein kinase domain containing protein	0.0006	0.016	0.0222
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0006	0.0167	0.0232
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0006	0.0167	0.0232
Echinococcus granulosus	tyrosine protein kinase Blk	0.0041	0.2035	0.8961
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.0004	0.0056	0.0245
Echinococcus granulosus	N chimaerin	0.0005	0.0093	0.0407
Brugia malayi	SH2 domain containing protein	0.0006	0.016	0.0222
Trichomonas vaginalis	DNA helicase recq, putative	0.0005	0.0116	0.0056
Loa Loa (eye worm)	steroid hormone receptor	0.0006	0.0167	0.0356
Schistosoma mansoni	GTPase activating protein	0.0005	0.0093	0.0366
Onchocerca volvulus		0.0005	0.0093	0.0093
Brugia malayi	Variant SH3 domain containing protein	0.0009	0.0328	0.0454
Echinococcus granulosus	growth factor receptor bound protein 2	0.0009	0.0328	0.1446
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0006	0.0167	0.0232
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0006	0.0167	0.0356
Brugia malayi	SH2 domain containing protein	0.0005	0.0093	0.0128
Echinococcus granulosus	signal transduction protein lnk realted	0.0005	0.0093	0.0407
Brugia malayi	Variant SH3 domain containing protein	0.0004	0.0086	0.012
Brugia malayi	SH2 domain containing protein	0.0005	0.0093	0.0128
Brugia malayi	Sex muscle abnormal protein 5	0.0009	0.0328	0.0454
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.004	0.1967	0.8662
Brugia malayi	steroid hormone receptor	0.0006	0.0167	0.0232
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0013	0.0546	0.216
Brugia malayi	photoreceptor-specific nuclear receptor	0.0006	0.0167	0.0232
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0005	0.0093	0.0407
Echinococcus granulosus	tyrosine protein kinase Src42A	0.004	0.1967	0.8662
Brugia malayi	Fibroblast growth factor family protein	0.0007	0.0206	0.0286
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0045	0.2271	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0041	0.2035	0.8961
Brugia malayi	Protein kinase domain containing protein	0.0006	0.016	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0167	0.0356
Brugia malayi	Tensin	0.0005	0.0093	0.0128
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0045	0.2271	1
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0167	0.0356
Schistosoma mansoni	slit-robo rho gtpase activating protein	0.0004	0.0086	0.0342
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0005	0.0116	0.0117
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0006	0.0167	0.0356
Trichomonas vaginalis	set domain proteins, putative	0.0104	0.537	1
Echinococcus multilocularis	tensin	0.0005	0.0093	0.0407
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0003	0.0018	0.0079
Brugia malayi	hypothetical protein	0.0003	0.0018	0.0025
Echinococcus granulosus	hypothetical protein	0.0005	0.0093	0.0407
Brugia malayi	Pre-SET motif family protein	0.0091	0.47	0.6502
Onchocerca volvulus		0.0005	0.0093	0.0093
Schistosoma mansoni	hypothetical protein	0.0005	0.0093	0.0366
Echinococcus multilocularis	tyrosine kinase	0.0006	0.016	0.0706
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0006	0.0167	0.0737
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0045	0.2271	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0006	0.0167	0.0662
Schistosoma mansoni	hypothetical protein	0.005	0.2528	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.0005	0.0093	0.0197
Onchocerca volvulus	Putative cortactin	0.0004	0.0086	0.0086
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0006	0.0167	0.0737
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0093	0.0197
Brugia malayi	RhoGAP domain containing protein	0.0005	0.0093	0.0128
Onchocerca volvulus		0.0006	0.016	0.016
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0013	0.0546	0.2404
Echinococcus multilocularis	fch and double sh3 domains protein 2	0.0004	0.0086	0.0381
Brugia malayi	Variant SH3 domain containing protein	0.0004	0.0086	0.012
Echinococcus multilocularis	slit robo rho gtpase activating protein 1	0.0004	0.0086	0.0381
Echinococcus granulosus	expressed conserved protein	0.0005	0.0093	0.0407
Schistosoma mansoni	growth factor receptor-bound protein	0.0009	0.0328	0.1299
Brugia malayi	SRC-1	0.0045	0.2271	0.3142
Schistosoma mansoni	tyrosine kinase	0.001	0.0396	0.1568
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0004	0.0056	0.0077
Schistosoma mansoni	DNA helicase recq5	0.0004	0.0056	0.0221
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0093	0.0197
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0006	0.0167	0.0737
Echinococcus granulosus	src region	0.0004	0.0086	0.0381
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0006	0.0167	0.0662
Brugia malayi	ecdysteroid receptor	0.0006	0.0167	0.0232
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0093	0.0197
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0005	0.0116	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0167	0.0356
Brugia malayi	Pre-SET motif family protein	0.0013	0.0546	0.0756
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0006	0.0167	0.0232
Loa Loa (eye worm)	SRC-1	0.0045	0.2271	0.4832
Brugia malayi	hypothetical protein	0.0003	0.0018	0.0025
Entamoeba histolytica	recQ family helicase, putative	0.0005	0.0116	0.0174
Echinococcus multilocularis	nostrin	0.0004	0.0086	0.0381
Schistosoma mansoni	dreadlocks/dock	0.0004	0.0086	0.0342
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0006	0.0167	0.0662
Loa Loa (eye worm)	TK/FER protein kinase	0.0006	0.016	0.0341
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0006	0.0167	0.0232
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0206	0.0439
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0086	0.0184
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0045	0.2271	1
Onchocerca volvulus		0.0004	0.0086	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0086	0.0184
Echinococcus multilocularis	N chimaerin	0.0005	0.0093	0.0407
Schistosoma mansoni	tensin-related	0.0005	0.0093	0.0366
Schistosoma mansoni	C-fyn	0.0004	0.0086	0.0342
Brugia malayi	Src substrate cortactin	0.0004	0.0086	0.012
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0005	0.0093	0.0407
Echinococcus multilocularis	transfer RNA-Ala	0.0004	0.0086	0.0381
Schistosoma mansoni	tyrosine kinase	0.0006	0.016	0.0635
Echinococcus multilocularis	SH2 motif	0.0005	0.0093	0.0407
Echinococcus granulosus	Spectrin alpha actinin	0.0004	0.0086	0.0381
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0167	0.0356
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0045	0.2271	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)		Inhibition of c-SRC in EGF-stimulated human A431 cells assessed as phosphorylated STAT3 level by Western blot assay	ChEMBL.	21459579
IC50 (binding)	> 10000 nM	Inhibition of c-SRC assessed as residual activity using KVEKIGEGYYGVVYK as peptide substrate after 20 mins by scintillation counting	ChEMBL.	21459579

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1765548

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1522321