Detailed information for compound 1527465

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 326.861 | Formula: C17H27ClN2O2
  • H donors: 3 H acceptors: 2 LogP: 2.84 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(c1ccccc1)CNCCNC(=O)C1CCCCC1.Cl
  • InChi: 1S/C17H26N2O2.ClH/c20-16(14-7-3-1-4-8-14)13-18-11-12-19-17(21)15-9-5-2-6-10-15;/h1,3-4,7-8,15-16,18,20H,2,5-6,9-13H2,(H,19,21);1H
  • InChiKey: HPYXGDXEXJNVBE-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.004 0.0079 0.0102
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0074 0.0349 0.046
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0106 0.0606 0.0602
Schistosoma mansoni hypothetical protein 0.0056 0.02 0.0266
Trichomonas vaginalis alpha-glucosidase, putative 0.0106 0.0606 0.0602
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0079 0.0075
Plasmodium falciparum cysteine proteinase falcipain 2a 0.006 0.0239 0.4306
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.023 0.1599 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0091 0.0116
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.006 0.0239 0.0239
Trypanosoma cruzi major cysteine proteinase, putative 0.0181 0.1204 0.7525
Loa Loa (eye worm) hypothetical protein 0.0053 0.0183 0.0183
Plasmodium falciparum cysteine proteinase falcipain 3 0.006 0.0239 0.4306
Loa Loa (eye worm) hypothetical protein 0.0252 0.1779 0.1779
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0116 0.0116
Schistosoma mansoni microtubule-associated protein tau 0.0679 0.5197 0.7043
Brugia malayi Trehalase protein 5 0.0087 0.0456 0.0456
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.006 0.0239 0.0235
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0049 0.0147 0.0191
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0074 0.0349 0.046
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0091 0.0116
Schistosoma mansoni cathepsin F (C01 family) 0.006 0.0239 0.0318
Mycobacterium tuberculosis Conserved protein 0.008 0.04 0.1008
Entamoeba histolytica alpha-amylase family protein 0.022 0.1522 1
Brugia malayi trehalase I 0.0087 0.0456 0.0456
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0239 0.0235
Loa Loa (eye worm) hypothetical protein 0.0436 0.3248 0.3248
Trichomonas vaginalis trehalase, putative 0.0252 0.1779 0.1776
Loa Loa (eye worm) hypothetical protein 0.0436 0.3248 0.3248
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.023 0.1599 1
Loa Loa (eye worm) hypothetical protein 0.0324 0.2354 0.2354
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0189 0.1267 0.1686
Loa Loa (eye worm) hypothetical protein 0.0165 0.1078 0.1078
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.023 0.1599 1
Brugia malayi Melibiase family protein 0.0075 0.0357 0.0357
Trichomonas vaginalis conserved hypothetical protein 0.0252 0.1779 0.1776
Onchocerca volvulus 0.006 0.0239 0.025
Trichomonas vaginalis alpha-glucosidase, putative 0.0091 0.0487 0.0483
Brugia malayi Glycosyl hydrolases family 31 protein 0.0091 0.0487 0.0487
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0131 0.0169
Trichomonas vaginalis alpha-amylase, putative 0.022 0.1522 0.1519
Echinococcus multilocularis protein patched 0.0042 0.0091 0.0116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0239 0.0235
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0239 0.0235
Brugia malayi Papain family cysteine protease containing protein 0.006 0.0239 0.0239
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.0551 0.0741
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0106 0.0606 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.006 0.0239 0.0235
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0074 0.0349 0.046
Brugia malayi hypothetical protein 0.0087 0.0456 0.0456
Onchocerca volvulus 0.0436 0.3248 0.4954
Echinococcus granulosus neutral alpha glucosidase AB 0.0106 0.0606 0.0803
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0079 0.0492
Trypanosoma brucei glycosyl hydrolase, putative 0.008 0.04 0.2501
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.006 0.0239 0.0235
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0079 0.0075
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0126 0.0761 1
Brugia malayi hypothetical protein 0.0252 0.1779 0.1779
Schistosoma mansoni alpha-glucosidase 0.0951 0.7378 1
Loa Loa (eye worm) hypothetical protein 0.0586 0.4452 0.4452
Loa Loa (eye worm) trehalase 0.0252 0.1779 0.1779
Brugia malayi Cathepsin L-like precursor 0.004 0.0079 0.0079
Trichomonas vaginalis glucosylceramidase, putative 0.1278 1 1
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0131 0.0172
Schistosoma mansoni hypothetical protein 0.0056 0.02 0.0266
Leishmania major cathepsin L-like protease 0.023 0.1599 1
Trichomonas vaginalis glucosylceramidase, putative 0.1278 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.023 0.1599 1
Trypanosoma cruzi cysteine peptidase, putative 0.006 0.0239 0.1472
Loa Loa (eye worm) hypothetical protein 0.0087 0.0456 0.0456
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0091 0.0487 0.3027
Onchocerca volvulus 0.006 0.0239 0.025
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0079 0.0075
Toxoplasma gondii glycosyltransferase 0.0098 0.054 0.8194
Trichomonas vaginalis alpha-glucosidase, putative 0.0091 0.0487 0.0483
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.006 0.0239 0.0235
Onchocerca volvulus Cathepsin L homolog 0.006 0.0239 0.025
Trypanosoma brucei unspecified product 0.0034 0.0027 0.0167
Entamoeba histolytica cysteine proteinase, putative 0.006 0.0239 0.1546
Echinococcus multilocularis neutral alpha glucosidase AB 0.0106 0.0606 0.0803
Loa Loa (eye worm) hypothetical protein 0.0098 0.0538 0.0538
Echinococcus multilocularis cathepsin L cysteine protease 0.006 0.0239 0.0313
Echinococcus multilocularis glucan (1,4 alpha), branching enzyme 1 0.0098 0.054 0.0715
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0131 0.0172
Trichomonas vaginalis glucosylceramidase, putative 0.0838 0.6477 0.6476
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0086 0.0447 0.06
Entamoeba histolytica 1,4-alpha-glucan branching enzyme, putative 0.0098 0.054 0.3528
Mycobacterium tuberculosis 1,4-alpha-glucan branching enzyme GlgB (glycogen branching enzyme) 0.0098 0.054 0.449
Schistosoma mansoni alpha glucosidase 0.0106 0.0606 0.0816
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0131 0.0169
Mycobacterium ulcerans glycosyl hydrolase 0.008 0.04 0.4704
Brugia malayi Glutamate receptor 1 precursor 0.0049 0.0147 0.0147
Echinococcus multilocularis microtubule associated protein 2 0.0679 0.5197 0.6931
Echinococcus multilocularis cathepsin l cysteine peptidase 0.006 0.0239 0.0313
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0079 0.0075
Brugia malayi Trehalase family protein 0.0252 0.1779 0.1779
Trypanosoma cruzi cruzipain precursor, putative 0.023 0.1599 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0239 0.0235
Trichomonas vaginalis glucosylceramidase, putative 0.0838 0.6477 0.6476
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.023 0.1599 1
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0074 0.0349 0.046
Entamoeba histolytica alpha-amylase family protein 0.022 0.1522 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0966 0.7497 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0091 0.0487 0.0483
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0239 0.0235
Onchocerca volvulus 0.0252 0.1779 0.2658
Loa Loa (eye worm) hypothetical protein 0.0087 0.0456 0.0456
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.023 0.1599 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0074 0.0349 0.046
Loa Loa (eye worm) runx1 0.0055 0.0193 0.0193
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0079 0.0492
Plasmodium vivax hypothetical protein, conserved 0.0099 0.0549 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.006 0.0239 0.0235
Chlamydia trachomatis glutamine binding protein 0.0126 0.0761 1
Schistosoma mansoni hypothetical protein 0.004 0.0079 0.0102
Onchocerca volvulus Cathepsin L homolog 0.006 0.0239 0.025
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0183 0.0239
Loa Loa (eye worm) hypothetical protein 0.0087 0.0456 0.0456
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0079 0.0468
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0126 0.0761 1
Brugia malayi Glutamate receptor 2 precursor 0.0049 0.0147 0.0147
Onchocerca volvulus 0.0252 0.1779 0.2658
Onchocerca volvulus 0.006 0.0239 0.025
Brugia malayi Cathepsin L-like precursor 0.006 0.0239 0.0239
Echinococcus granulosus glutamate receptor 2 0.0074 0.0349 0.046
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0079 0.0492
Loa Loa (eye worm) hypothetical protein 0.0252 0.1779 0.1779
Trypanosoma cruzi hypothetical protein, conserved 0.0106 0.0606 0.3775
Trichomonas vaginalis glucosylceramidase, putative 0.0883 0.6839 0.6838
Loa Loa (eye worm) hypothetical protein 0.0098 0.054 0.054
Brugia malayi Cathepsin L-like precursor 0.006 0.0239 0.0239
Echinococcus granulosus expressed conserved protein 0.0092 0.0491 0.065
Echinococcus multilocularis cysteine protease 0.006 0.0239 0.0313
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0106 0.0606 0.3965
Echinococcus multilocularis Niemann Pick C1 protein 0.014 0.0875 0.1162
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0075 0.0357 0.0479
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0239 0.0235
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0116 0.0151
Onchocerca volvulus 0.0252 0.1779 0.2658
Onchocerca volvulus 0.006 0.0239 0.025
Trichomonas vaginalis alpha-amylase, putative 0.022 0.1522 0.1519
Leishmania major glycosyl hydrolase-like protein 0.0091 0.0487 0.1824
Brugia malayi Trehalase family protein 0.0252 0.1779 0.1779
Trypanosoma cruzi cysteine peptidase, putative 0.023 0.1599 1
Entamoeba histolytica cysteine proteinase, putative 0.006 0.0239 0.1546
Brugia malayi Glycosyl hydrolases family 31 protein 0.0966 0.7497 0.7497
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.006 0.0239 0.0235
Echinococcus multilocularis glutamate receptor NMDA 0.052 0.3924 0.5231
Echinococcus granulosus nmda type glutamate receptor 0.0545 0.4125 0.55
Loa Loa (eye worm) hypothetical protein 0.0087 0.0456 0.0456
Trichomonas vaginalis glucosylceramidase, putative 0.1278 1 1
Plasmodium vivax vivapain-2 0.006 0.0239 0.4306
Toxoplasma gondii alpha amylase, catalytic domain-containing protein 0.0098 0.054 0.8194
Onchocerca volvulus Trehalase homolog 0.0252 0.1779 0.2658
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0099 0.0549 1
Onchocerca volvulus Glucosylceramidase homolog 0.0838 0.6477 1
Brugia malayi Cathepsin L-like precursor 0.006 0.0239 0.0239
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.0538 0.0713
Onchocerca volvulus 0.0252 0.1779 0.2658
Loa Loa (eye worm) hypothetical protein 0.004 0.0079 0.0079
Trichomonas vaginalis alpha-glucosidase, putative 0.0106 0.0606 0.0602
Schistosoma mansoni lozenge 0.0055 0.0193 0.0256
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0131 0.0169
Plasmodium vivax vivapain-2 0.006 0.0239 0.4306
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0079 0.0492
Onchocerca volvulus Cathepsin F homolog 0.006 0.0239 0.025
Trypanosoma brucei glycosyl hydrolase-like protein 0.0091 0.0487 0.3045
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0131 0.0172
Brugia malayi hypothetical protein 0.0087 0.0456 0.0456
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0966 0.7497 0.7497
Schistosoma mansoni eyes absent homolog 0.0087 0.0456 0.0613
Echinococcus granulosus cathepsin l1 0.006 0.0239 0.0313
Echinococcus granulosus cathepsin l cysteine peptidase 0.006 0.0239 0.0313
Loa Loa (eye worm) TRE-1 protein 0.0252 0.1779 0.1779
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0131 0.0082
Loa Loa (eye worm) hypothetical protein 0.0051 0.0167 0.0167
Echinococcus multilocularis protein dispatched 1 0.0048 0.0139 0.018
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.006 0.0239 0.0235
Loa Loa (eye worm) hypothetical protein 0.0091 0.0487 0.0487
Toxoplasma gondii 1,4-alpha-glucan-branching enzyme 0.0098 0.054 0.8194
Echinococcus granulosus lysosomal alpha glucosidase 0.0966 0.7497 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0189 0.1267 0.1686
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0049 0.0147 0.0191
Trichomonas vaginalis alpha-glucosidase, putative 0.0091 0.0487 0.0483
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0079 0.0468
Brugia malayi Trehalase family protein 0.0252 0.1779 0.1779
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.006 0.0239 0.0235
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.023 0.1599 1
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.0027 0.0167
Leishmania major cathepsin L-like protease 0.023 0.1599 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0239 0.0235
Loa Loa (eye worm) trehalase 0.0087 0.0456 0.0456
Trichomonas vaginalis glucosylceramidase, putative 0.0838 0.6477 0.6476
Loa Loa (eye worm) hypothetical protein 0.0075 0.0357 0.0357
Loa Loa (eye worm) hypothetical protein 0.0252 0.1779 0.1779
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0183 0.0183
Echinococcus granulosus glucan 14 alpha branching enzyme 1 0.0098 0.054 0.0715
Entamoeba histolytica cysteine proteinase, putative 0.004 0.0079 0.0492
Echinococcus multilocularis cathepsin l cysteine peptidase 0.006 0.0239 0.0313
Loa Loa (eye worm) papain family cysteine protease containing protein 0.006 0.0239 0.0239
Echinococcus granulosus cathepsin l1 0.004 0.0079 0.01
Echinococcus granulosus Niemann Pick C1 protein 0.014 0.0875 0.1162
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.023 0.1599 1
Schistosoma mansoni glutamate receptor kainate 0.0049 0.0147 0.0194
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0091 0.0087
Trichomonas vaginalis glucosylceramidase, putative 0.1278 1 1
Echinococcus granulosus geminin 0.0056 0.02 0.0261
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0049 0.0147 0.0191
Loa Loa (eye worm) trehalase 0.0252 0.1779 0.1779
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.021 0.1439 0.8997
Echinococcus granulosus glutamate receptor subunit protein glur 0.0049 0.0147 0.0191
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0131 0.0169
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0074 0.0349 0.046
Trichomonas vaginalis amylase, putative 0.0098 0.054 0.0536
Echinococcus granulosus microtubule associated protein 2 0.0679 0.5197 0.6931
Brugia malayi Papain family cysteine protease containing protein 0.0031 0.0004 0.0004
Loa Loa (eye worm) cysteine protease 0.006 0.0239 0.0239
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0116 0.0149
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0239 0.0235
Plasmodium falciparum cysteine proteinase falcipain 2b 0.006 0.0239 0.4306
Schistosoma mansoni hypothetical protein 0.004 0.0079 0.0102
Loa Loa (eye worm) hypothetical protein 0.0047 0.0131 0.0131
Schistosoma mansoni glutamate receptor NMDA 0.0594 0.4518 0.6121
Echinococcus granulosus nmda type glutamate receptor 0.0694 0.5323 0.7098
Trichomonas vaginalis maltase-glucoamylase, putative 0.0106 0.0606 0.0602
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0079 0.0492
Loa Loa (eye worm) glutamate receptor 2 0.0049 0.0147 0.0147
Mycobacterium leprae Possible hydrolase 0.008 0.04 0.5
Schistosoma mansoni cathepsin F (C01 family) 0.004 0.0079 0.0101
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0116 0.0149
Echinococcus multilocularis glutamate receptor 2 0.0049 0.0147 0.0191
Trichomonas vaginalis alpha-amylase, putative 0.0196 0.1329 0.1325
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0079 0.0492
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0091 0.0487 0.0638
Trypanosoma cruzi hypothetical protein, conserved 0.0106 0.0606 0.3775
Leishmania major glycosyl hydrolase, putative 0.008 0.04 0.1184
Brugia malayi Trehalase family protein 0.0087 0.0456 0.0456
Toxoplasma gondii melibiase subfamily protein 0.0086 0.0447 0.5661
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0079 0.0492
Trichomonas vaginalis alpha-glucosidase, putative 0.0091 0.0487 0.0483
Loa Loa (eye worm) ctsf protein 0.006 0.0239 0.0239
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0116 0.0151
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0079 0.0468
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0086 0.0447 0.06
Trichomonas vaginalis glucosylceramidase, putative 0.0838 0.6477 0.6476
Loa Loa (eye worm) trehalase 0.0252 0.1779 0.1779
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0074 0.0349 0.046
Schistosoma mansoni hypothetical protein 0.0049 0.0147 0.0194
Trypanosoma brucei glucosidase, putative 0.0106 0.0606 0.3791
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0252 0.1779 0.1779
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0183 0.0243
Brugia malayi trehalase 0.0087 0.0456 0.0456
Brugia malayi Cathepsin L-like precursor 0.006 0.0239 0.0239
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.023 0.1599 1
Onchocerca volvulus 0.0639 0.4877 0.75
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0239 0.0235
Trichomonas vaginalis amylase, putative 0.022 0.1522 0.1519
Loa Loa (eye worm) glutamate receptor 1 0.0049 0.0147 0.0147
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0075 0.0357 0.0479
Trichomonas vaginalis glucosylceramidase, putative 0.0838 0.6477 0.6476
Entamoeba histolytica cysteine protease, putative 0.006 0.0239 0.1546
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0086 0.0447 0.06
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.0538 0.0713
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0239 0.0235
Brugia malayi Glycosyl hydrolases family 31 protein 0.0106 0.0606 0.0606
Loa Loa (eye worm) hypothetical protein 0.0042 0.0091 0.0091
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0074 0.0349 0.046
Trichomonas vaginalis glucosylceramidase, putative 0.0883 0.6839 0.6838
Echinococcus granulosus glutamate NMDA receptor subunit 0.0049 0.0147 0.0191
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0126 0.0761 1
Schistosoma mansoni hypothetical protein 0.004 0.0079 0.0102
Trichomonas vaginalis glucosylceramidase, putative 0.0838 0.6477 0.6476
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0183 0.0239
Trichomonas vaginalis alpha-glucosidase, putative 0.0106 0.0606 0.0602
Brugia malayi Trehalase family protein 0.0087 0.0456 0.0456
Brugia malayi hypothetical protein 0.0436 0.3248 0.3248
Schistosoma mansoni beta-galactosidase 0.0324 0.2354 0.3187
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0239 0.0235
Echinococcus multilocularis nmda type glutamate receptor 0.0694 0.5323 0.7098
Trichomonas vaginalis alpha-amylase, putative 0.022 0.1522 0.1519
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.1278 1 1
Schistosoma mansoni ATP-binding cassette transporter 0.0049 0.0147 0.0194
Trichomonas vaginalis glucosylceramidase, putative 0.1278 1 1
Mycobacterium ulcerans glycogen branching protein 0.0098 0.054 0.6755
Onchocerca volvulus 0.006 0.0239 0.025
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0049 0.0147 0.0191
Trichomonas vaginalis alpha-glucosidase, putative 0.0106 0.0606 0.0602
Schistosoma mansoni glutamate receptor AMPA 0.0049 0.0147 0.0194
Giardia lamblia 1,4-alpha-glucan branching enzyme 0.0098 0.054 0.5
Trypanosoma cruzi cysteine peptidase, putative 0.023 0.1599 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.0456 0.0456
Brugia malayi hypothetical protein 0.0087 0.0456 0.0456
Onchocerca volvulus 0.0252 0.1779 0.2658
Schistosoma mansoni hypothetical protein 0.0289 0.2072 0.2804
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0239 0.0235
Trichomonas vaginalis alpha-amylase, putative 0.022 0.1522 0.1519
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0049 0.0147 0.0191
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0049 0.0147 0.0191
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0091 0.0487 0.0483
Onchocerca volvulus 0.006 0.0239 0.025
Brugia malayi CHE-14 protein 0.0042 0.0091 0.0091
Echinococcus granulosus glutamate receptor NMDA 0.052 0.3924 0.5231
Trichomonas vaginalis alpha-glucosidase, putative 0.0091 0.0487 0.0483
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0091 0.0487 0.318
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.023 0.1599 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0239 0.0239
Echinococcus multilocularis Protein lozenge 0.0055 0.0193 0.0252
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0126 0.0761 1
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0086 0.0447 0.0591
Brugia malayi hypothetical protein 0.0087 0.0456 0.0456
Echinococcus multilocularis cathepsin L cysteine protease 0.006 0.0239 0.0313
Loa Loa (eye worm) hypothetical protein 0.0087 0.0456 0.0456
Echinococcus multilocularis dna polymerase kappa 0.004 0.0079 0.01
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0091 0.0487 0.0483
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0106 0.0606 0.0602
Schistosoma mansoni glutamate receptor NMDA 0.0049 0.0147 0.0194
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0239 0.0235
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0091 0.0487 0.3027
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.0538 0.352
Leishmania major alpha glucosidase II subunit, putative 0.0106 0.0606 0.2701
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0239 0.0235
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0106 0.0606 0.3965
Trypanosoma cruzi cysteine peptidase, putative 0.023 0.1599 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0116 0.0149
Schistosoma mansoni alpha-glucosidase 0.0951 0.7378 1
Trichomonas vaginalis starch branching enzyme II, putative 0.0098 0.054 0.0536
Schistosoma mansoni glutamate receptor kainate 0.0049 0.0147 0.0194
Loa Loa (eye worm) trehalase 0.0087 0.0456 0.0456
Brugia malayi Cathepsin L-like precursor 0.004 0.0079 0.0079
Echinococcus multilocularis glutamate receptor 2 0.0074 0.0349 0.046
Brugia malayi 1,4-alpha-glucan branching enzyme 0.0098 0.054 0.054
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0091 0.0091
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.006 0.0239 0.0235
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0031 0.0004 0.0026
Brugia malayi Cathepsin L-like cysteine proteinase 0.004 0.0079 0.0079
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0183 0.0239
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0116 0.0151
Echinococcus granulosus dna polymerase kappa 0.004 0.0079 0.01
Schistosoma mansoni glutamate receptor AMPA 0.0049 0.0147 0.0194
Trichomonas vaginalis glucosylceramidase, putative 0.0838 0.6477 0.6476
Brugia malayi Trehalase family protein 0.0252 0.1779 0.1779
Trichomonas vaginalis sucrase-isomaltase, putative 0.0106 0.0606 0.0602
Echinococcus multilocularis beta galactosidase 0.0324 0.2354 0.3136
Loa Loa (eye worm) fibroinase 0.006 0.0239 0.0239
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0805 0.6209 0.8281
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0106 0.0606 0.0606
Schistosoma mansoni cathepsin F (C01 family) 0.006 0.0239 0.0318
Trichomonas vaginalis amylase, putative 0.022 0.1522 0.1519
Echinococcus multilocularis lysosomal alpha glucosidase 0.0966 0.7497 1
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0079 0.0492
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0075 0.0357 0.0353
Loa Loa (eye worm) TRE-2 protein 0.0252 0.1779 0.1779
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0131 0.0131
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0079 0.0492
Leishmania major cathepsin L-like protease 0.023 0.1599 1
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0091 0.0116
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0079 0.0468
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.0538 0.0538
Schistosoma mansoni starch branching enzyme II 0.0098 0.054 0.0726
Loa Loa (eye worm) hypothetical protein 0.004 0.0079 0.0079
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0079 0.0492
Brugia malayi cathepsin L-like precursor 0.004 0.0079 0.0079
Echinococcus multilocularis nmda type glutamate receptor 0.0545 0.4125 0.55
Brugia malayi Cathepsin L-like precursor 0.006 0.0239 0.0239
Echinococcus multilocularis NMDA receptor 0.0049 0.0147 0.0191
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0174 0.1154 0.1534
Brugia malayi mbt repeat family protein 0.0047 0.0131 0.0131
Brugia malayi mbt repeat family protein 0.0047 0.0131 0.0131
Brugia malayi Papain family cysteine protease containing protein 0.0031 0.0004 0.0004
Echinococcus multilocularis expressed conserved protein 0.0092 0.0491 0.065
Onchocerca volvulus 0.0047 0.0131 0.0082
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0116 0.0149
Schistosoma mansoni patched 1 0.0042 0.0091 0.0118
Trichomonas vaginalis glucosylceramidase, putative 0.1278 1 1
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0086 0.0447 0.0591
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.006 0.0239 0.0235
Loa Loa (eye worm) MBCTL1 0.0053 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0252 0.1779 0.1779
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.006 0.0239 0.0235
Echinococcus multilocularis geminin 0.0056 0.02 0.0261
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0031 0.0004 0.0026
Echinococcus granulosus cathepsin L cysteine proteinase 0.006 0.0239 0.0313
Echinococcus granulosus beta galactosidase 0.0324 0.2354 0.3136
Entamoeba histolytica 1,4-alpha-glucan branching enzyme, putative 0.0098 0.054 0.3528
Schistosoma mansoni glutamate receptor kainate 0.0049 0.0147 0.0194
Loa Loa (eye worm) hypothetical protein 0.004 0.0079 0.0079
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0183 0.0239
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0126 0.0761 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.023 0.1599 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0106 0.0606 0.0602
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0086 0.0447 0.06
Brugia malayi Cathepsin L-like precursor 0.006 0.0239 0.0239
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0079 0.0492
Trypanosoma cruzi glycosyl hydrolase, putative 0.008 0.04 0.2481
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0049 0.0147 0.0191
Onchocerca volvulus 0.006 0.0239 0.025
Echinococcus multilocularis cysteine protease 0.006 0.0239 0.0313
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0086 0.0447 0.0591

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 0.16 mg kg-1 In vivo beta-adrenoceptor blocking potency measured by by blockade of the isoproterenol tachycardia response in rat ChEMBL. 6102152
ED50 (functional) = 240 ug kg-1 Beta-adrenoceptor blocking potency in cat as dose causing 50% inhibition of the tachycardia produced by 0.2 ug/kg iv of isoproterenol ChEMBL. 6102152

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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