Detailed information for compound 1537892

Basic information

Technical information
  • TDR Targets ID: 1537892
  • Name: (5E)-1-butyl-5-[1-(oxolan-2-ylmethylamino)eth ylidene]-1,3-diazinane-2,4,6-trione
  • MW: 309.361 | Formula: C15H23N3O4
  • H donors: 2 H acceptors: 3 LogP: 1.87 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCN1C(=O)NC(=O)/C(=C(\NCC2CCCO2)/C)/C1=O
  • InChi: 1S/C15H23N3O4/c1-3-4-7-18-14(20)12(13(19)17-15(18)21)10(2)16-9-11-6-5-8-22-11/h11,16H,3-9H2,1-2H3,(H,17,19,21)/b12-10+
  • InChiKey: DYPMZRYQWSEXKI-ZRDIBKRKSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (5E)-1-butyl-5-[1-(tetrahydrofuran-2-ylmethylamino)ethylidene]hexahydropyrimidine-2,4,6-trione
  • (5E)-1-butyl-5-[1-(2-tetrahydrofuranylmethylamino)ethylidene]hexahydropyrimidine-2,4,6-trione
  • (5E)-1-butyl-5-[1-(tetrahydrofurfurylamino)ethylidene]barbituric acid
  • 1-Butyl-5-[1-[(tetrahydro-furan-2-ylmethyl)-amino]-eth-(E)-ylidene]-pyrimidine-2,4,6-trione
  • MLS000557923
  • SMR000148639
  • STOCK4S-30829

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens snurportin 1 No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0373 0.0373
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.0033 0.0169 0.0297
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0169 0.0169
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0115 0.0258
Loa Loa (eye worm) hypothetical protein 0.0473 0.5707 1
Leishmania major hypothetical protein, conserved 0.0033 0.0169 1
Schistosoma mansoni ran 0.0026 0.0082 0.0082
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0033 0.0169 0.0169
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.0033 0.0169 0.0169
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0169 1
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0033 0.0169 0.0264
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0033 0.0169 0.0169
Schistosoma mansoni lipoxygenase 0.0058 0.0486 0.0486
Echinococcus multilocularis voltage gated potassium channel 0.0049 0.0373 0.0373
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0033 0.0169 0.0169
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0019 0.0966
Leishmania major cyclic nucleotide-binding protein-like protein 0.0033 0.0169 1
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0373 0.0373
Loa Loa (eye worm) hypothetical protein 0.0033 0.0169 0.0297
Toxoplasma gondii cAMP-dependent protein kinase regulatory subunit 0.0033 0.0169 0.8558
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0169 0.0169
Leishmania major regulatory subunit of protein kinase a-like protein 0.0033 0.0169 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0033 0.0169 0.0169
Loa Loa (eye worm) AGC/PKG protein kinase 0.0033 0.0169 0.0297
Loa Loa (eye worm) hypothetical protein 0.0473 0.5707 1
Trypanosoma cruzi cAMP response protein 1 0.0033 0.0169 1
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0019 0.0034
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0082 0.416
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.0169 0.0394
Schistosoma mansoni importin beta-1 0.0035 0.0198 0.0198
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.0033 0.0169 1
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0019 0.0966
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0082 0.4861
Leishmania major GTP-binding protein, putative 0.0026 0.0082 0.4861
Echinococcus granulosus cGMP dependent protein kinase 1 0.0033 0.0169 0.0169
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0082 0.416
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0082 0.0082
Schistosoma mansoni rab6-interacting 0.0021 0.0019 0.0019
Trypanosoma brucei Flagellar Member 6 0.0033 0.0169 0.8558
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.0033 0.0169 0.0169
Plasmodium falciparum importin beta, putative 0.0035 0.0198 1
Onchocerca volvulus 0.0473 0.5707 1
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.0033 0.0169 0.0394
Mycobacterium ulcerans regulatory protein 0.0033 0.0169 1
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0033 0.0169 0.0169
Schistosoma mansoni polycystin 1-related 0.0021 0.0019 0.0019
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0115 0.0258
Plasmodium vivax CAMP-dependent protein kinase regulatory subunit, putative 0.0033 0.0169 0.8558
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.0033 0.0169 0.0394
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0058 0.0486 0.0486
Chlamydia trachomatis cAMP-dependent protein kinase regulatory subunit 0.0033 0.0169 0.5
Brugia malayi hypothetical protein 0.0473 0.5707 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0034
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.0033 0.0169 0.0169
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0049 0.0373 0.0654
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0169 0.0169
Schistosoma mansoni loxhd1 0.0021 0.0019 0.0019
Brugia malayi Cyclic-nucleotide gated cation channel 0.0049 0.0373 0.0654
Echinococcus granulosus cGMP dependent protein kinase 0.0033 0.0169 0.0169
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0082 0.416
Echinococcus granulosus snurportin 1 0.0372 0.4436 0.4436
Brugia malayi N-terminal motif family protein 0.0033 0.0169 0.0297
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0373 0.0373
Treponema pallidum cyclic nucleotide binding protein 0.0033 0.0169 1
Echinococcus granulosus patatin phospholipase domain containing protein 0.0033 0.0169 0.0169
Entamoeba histolytica hypothetical protein 0.0028 0.0115 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0049 0.0373 0.0373
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.0033 0.0169 0.0169
Trichomonas vaginalis ran, putative 0.0026 0.0082 0.0175
Loa Loa (eye worm) hypothetical protein 0.0033 0.0169 0.0297
Leishmania major protein kinase A regulatory subunit, putative 0.0033 0.0169 1
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.0033 0.0169 0.0169
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0013 0.0022
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.0033 0.0169 0.0297
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0033 0.0169 1
Mycobacterium ulcerans hypothetical protein 0.0033 0.0169 1
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0049 0.0373 0.0654
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0115 0.0258
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0033 0.0169 0.8558
Treponema pallidum catabolite gene activator (Crp) 0.0033 0.0169 1
Mycobacterium tuberculosis Conserved protein 0.0033 0.0169 1
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0033 0.0169 0.0169
Giardia lamblia CAMP-dependent protein kinase regulatory chain 0.0033 0.0169 1
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0033 0.0169 0.8558
Mycobacterium ulcerans hypothetical protein 0.0033 0.0169 1
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.0033 0.0169 0.0297
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0373 0.0373
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0082 0.0082
Mycobacterium ulcerans transcriptional regulatory protein 0.0033 0.0169 1
Schistosoma mansoni hypothetical protein 0.0021 0.0019 0.0019
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0049 0.0373 0.0373
Schistosoma mansoni rab6-interacting 0.0021 0.0019 0.0019
Mycobacterium ulcerans hypothetical protein 0.0033 0.0169 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0049 0.0373 0.0373
Echinococcus granulosus cGMP dependent protein kinase 1 0.0033 0.0169 0.0169
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.0033 0.0169 0.0297
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0013 0.0631
Mycobacterium tuberculosis Conserved hypothetical protein 0.0033 0.0169 1
Schistosoma mansoni ap endonuclease 0.002 0.0013 0.0013
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0033 0.0169 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0049 0.0373 0.0906
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0013 0.0013
Trypanosoma brucei cAMP binding protein, putative 0.0033 0.0169 0.8558
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0082 0.0144
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0049 0.0373 0.0373
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0013 0.0738
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0814 1 1
Brugia malayi hypothetical protein 0.0021 0.0019 0.0034
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.0169 0.0394
Echinococcus multilocularis RUN 0.0021 0.0019 0.0019
Schistosoma mansoni ap endonuclease 0.002 0.0013 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0169 0.0394
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.4436 0.7773
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0198 1
Brugia malayi Doublecortin family protein 0.0021 0.0019 0.0034
Brugia malayi Importin beta-1 subunit 0.0035 0.0198 0.0347
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0198 1
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0033 0.0169 0.0169
Leishmania major protein kinase, putative 0.0033 0.0169 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0082 0.4861
Brugia malayi Egg laying defective protein 4 0.0033 0.0169 0.0297
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.0033 0.0169 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0814 1 1
Plasmodium vivax rap guanine nucleotide exchange factor, putative 0.0033 0.0169 0.8558
Trypanosoma cruzi Flagellar Member 6 0.0033 0.0169 1
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0049 0.0373 0.0373
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0034
Brugia malayi RNA, U transporter 1 0.0099 0.1006 0.1762
Trypanosoma cruzi cyclic nucleotide-binding domain containing protein, putative 0.0033 0.0169 1
Loa Loa (eye worm) runx1 0.0059 0.0506 0.0887
Echinococcus multilocularis patatin phospholipase domain containing protein 0.0033 0.0169 0.0169
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0013 0.5
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0049 0.0373 0.0373
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0814 1 1
Plasmodium falciparum cAMP-dependent protein kinase regulatory subunit 0.0033 0.0169 0.8558
Echinococcus granulosus importin subunit beta 1 0.0035 0.0198 0.0198
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0033 0.0169 0.0169
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0337 0.3999 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0013 0.0738
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0033 0.0169 0.8558
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0049 0.0373 0.0373
Schistosoma mansoni similar to Protein C20orf152 homolog 0.0033 0.0169 0.0169
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0049 0.0373 0.0654
Echinococcus multilocularis Protein lozenge 0.0059 0.0506 0.0506
Loa Loa (eye worm) hypothetical protein 0.0035 0.0198 0.0347
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0013 0.0631
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0082 0.4451
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0019 0.0019
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0033 0.0169 0.0169
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.0169 0.0394
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0049 0.0373 0.0373
Mycobacterium leprae Conserved hypothetical protein 0.0033 0.0169 0.5
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0033 0.0169 1
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0049 0.0373 0.0654
Leishmania major importin beta-1 subunit, putative 0.0028 0.0115 0.6797
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0013 0.0631
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0013 0.0738
Leishmania major protein kinase, putative 0.0033 0.0169 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0373 0.0654
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0033 0.0169 0.8558
Mycobacterium ulcerans transmembrane transport protein 0.0033 0.0169 1
Leishmania major hypothetical protein, unknown function 0.0033 0.0169 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0019 0.0019
Toxoplasma gondii exonuclease III APE 0.002 0.0013 0.0631
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.0033 0.0169 0.0169
Leishmania major hypothetical protein, conserved 0.0033 0.0169 1
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.0033 0.0169 0.0169
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0013 0.0022
Onchocerca volvulus 0.0033 0.0169 0.0264
Schistosoma mansoni hypothetical protein 0.0372 0.4436 0.4436
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0033 0.0169 0.0169
Echinococcus granulosus Ion_trans_N domain containing protein 0.0477 0.5761 0.5761
Onchocerca volvulus 0.0033 0.0169 0.0264
Trypanosoma cruzi protein kinase A regulatory subunit 0.0033 0.0169 1
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0033 0.0169 0.8558
Mycobacterium tuberculosis Probable transcriptional regulatory protein Cmr 0.0033 0.0169 1
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0033 0.0169 0.8558
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0019 0.0019
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.0033 0.0169 0.0169
Echinococcus multilocularis hyperpolarization activated cyclic 0.0814 1 1
Brugia malayi hypothetical protein 0.0021 0.0019 0.0034
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0198 1
Echinococcus multilocularis hyperpolarization activated cyclic 0.0814 1 1
Schistosoma mansoni hypothetical protein 0.0477 0.5761 0.5761
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0049 0.0373 0.0373
Mycobacterium ulcerans hypothetical protein 0.0033 0.0169 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0049 0.0373 0.0373
Schistosoma mansoni lozenge 0.0059 0.0506 0.0506
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0814 1 1
Echinococcus multilocularis expressed conserved protein 0.0033 0.0169 0.0169
Loa Loa (eye worm) hypothetical protein 0.0049 0.0373 0.0654
Trypanosoma brucei protein kinase A regulatory subunit 0.0033 0.0169 0.8558
Plasmodium vivax importin-beta 2, putative 0.0035 0.0198 1
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.0033 0.0169 0.0169
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0198 0.0198
Treponema pallidum catabolite gene activator 0.0033 0.0169 1
Entamoeba histolytica Ran family GTPase 0.0026 0.0082 0.6805
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.0033 0.0169 0.0169
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0049 0.0373 0.0373
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0373 0.0373
Echinococcus granulosus hyperpolarization activated cyclic 0.0814 1 1
Echinococcus multilocularis snurportin 1 0.0372 0.4436 0.4436
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0033 0.0169 0.0169
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0049 0.0373 0.0654
Echinococcus multilocularis hypothetical protein 0.0477 0.5761 0.5761
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0019 0.0019
Trypanosoma cruzi cAMP binding protein, putative 0.0033 0.0169 1
Trypanosoma cruzi cAMP response protein 1, putative 0.0033 0.0169 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0049 0.0373 0.0373
Mycobacterium tuberculosis Conserved hypothetical protein 0.0033 0.0169 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0321 0.3795 0.3795
Treponema pallidum cyclic nucleotide binding protein 0.0033 0.0169 1
Plasmodium falciparum cGMP-dependent protein kinase 0.0033 0.0169 0.8558
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0082 0.416
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0013 0.0738
Leishmania major hypothetical protein, conserved 0.0033 0.0169 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0115 0.6797
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0033 0.0169 0.8558
Echinococcus granulosus RUN 0.0021 0.0019 0.0019
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0019 0.0019
Schistosoma mansoni ran 0.0026 0.0082 0.0082
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0019 0.0019
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.0169 0.0394
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0082 0.0144
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0058 0.0486 0.0486
Trypanosoma brucei cAMP response protein 1, putative 0.0033 0.0169 0.8558
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0033 0.0169 0.0169
Schistosoma mansoni lipoxygenase 0.0021 0.0019 0.0019
Echinococcus granulosus voltage gated potassium channel 0.0049 0.0373 0.0373

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.4611 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5131 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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