Detailed information for compound 1547057

Basic information

Technical information
  • TDR Targets ID: 1547057
  • Name: T5256742
  • MW: 233.263 | Formula: C13H15NO3
  • H donors: 1 H acceptors: 2 LogP: 1.41 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NCc1ccccc1)COC(=O)C1CC1
  • InChi: 1S/C13H15NO3/c15-12(9-17-13(16)11-6-7-11)14-8-10-4-2-1-3-5-10/h1-5,11H,6-9H2,(H,14,15)
  • InChiKey: SAJJHMABYYZVRE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ZINC02617670

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.1579 0.379 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.4137 1 1
Brugia malayi Protein-tyrosine phosphatase 0.0161 0.0347 0.0347
Schistosoma mansoni calpain-7 (C02 family) 0.0022 0.0009 0.0008
Trypanosoma cruzi kinesin, putative 0.0022 0.0009 0.0081
Onchocerca volvulus 0.0161 0.0347 0.0868
Onchocerca volvulus 0.0182 0.0399 0.1006
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0096 0.0094
Echinococcus multilocularis 0.0161 0.0347 0.0346
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0051 0.0448
Mycobacterium ulcerans hypothetical protein 0.0026 0.002 0.0053
Schistosoma mansoni hypothetical protein 0.0361 0.0834 0.0832
Loa Loa (eye worm) hypothetical protein 0.0026 0.002 0.002
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0006 0.0552
Loa Loa (eye worm) hypothetical protein 0.0026 0.002 0.002
Echinococcus granulosus calpain 0.0022 0.0009 0.0008
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0171 0.0372 0.0372
Trypanosoma cruzi hypothetical protein, conserved 0.0487 0.1138 1
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.0101 0.02 0.1759
Onchocerca volvulus 0.0161 0.0347 0.0868
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0161 0.0347 0.0347
Leishmania major hypothetical protein, conserved 0.0487 0.1138 1
Mycobacterium ulcerans hypothetical protein 0.0028 0.0023 0.0061
Brugia malayi hypothetical protein 0.0182 0.0399 0.0399
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0051 0.011
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0004 0.0008
Schistosoma mansoni transcription factor LCR-F1 0.0078 0.0146 0.0144
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0161 0.0347 0.0346
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0016 0.0137
Entamoeba histolytica hypothetical protein 0.0078 0.0146 0.0362
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0051 0.576
Toxoplasma gondii thioredoxin reductase 0.0054 0.0087 0.4323
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0004 0.0008
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0002 0.0013
Brugia malayi hypothetical protein 0.0161 0.0347 0.0347
Onchocerca volvulus 0.1579 0.379 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0161 0.0347 0.0347
Loa Loa (eye worm) hypothetical protein 0.0028 0.0023 0.0023
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0019 0.0002 0.0004
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0171 0.0372 0.037
Echinococcus multilocularis neuropeptide s receptor 0.0476 0.1112 0.1111
Leishmania major DNA/RNA non-specific endonuclease-like protein 0.0101 0.02 0.1759
Trypanosoma cruzi endonuclease G, putative 0.0101 0.02 0.1759
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0022 0.0009 0.0081
Echinococcus granulosus gpi ethanolamine phosphate transferase 3 0.0026 0.002 0.0018
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0141 0.0299 0.0297
Onchocerca volvulus 0.0474 0.1108 0.2886
Brugia malayi RNA binding protein 0.0206 0.0456 0.0456
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0051 0.0051
Echinococcus granulosus calpain 7 C02 family 0.0022 0.0009 0.0008
Brugia malayi hypothetical protein 0.0026 0.002 0.002
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0167 0.0362 0.0361
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0161 0.0347 0.0347
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0051 0.4964
Loa Loa (eye worm) hypothetical protein 0.0161 0.0347 0.0347
Loa Loa (eye worm) hypothetical protein 0.0161 0.0347 0.0347
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0022 0.0009 0.0081
Loa Loa (eye worm) glutathione reductase 0.0054 0.0087 0.0087
Onchocerca volvulus 0.0161 0.0347 0.0868
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0161 0.0347 0.0347
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0167 0.0362 0.0361
Trypanosoma cruzi hypothetical protein, conserved 0.0487 0.1138 1
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0171 0.0372 0.037
Entamoeba histolytica hypothetical protein 0.0078 0.0146 0.0362
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0083 0.0083
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0171 0.0372 0.037
Plasmodium vivax thioredoxin reductase, putative 0.0054 0.0087 0.8619
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.1579 0.379 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0123 0.0256 0.0975
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0161 0.0347 0.0346
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0167 0.0362 0.0361
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0161 0.0347 0.0347
Loa Loa (eye worm) hypothetical protein 0.0025 0.0016 0.0016
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0161 0.0347 0.0346
Loa Loa (eye worm) hypothetical protein 0.0159 0.0342 0.0342
Brugia malayi hypothetical protein 0.0078 0.0146 0.0146
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0161 0.0347 0.0346
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0161 0.0347 0.0347
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0051 0.0448
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.006 0.0101 0.01
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0167 0.0362 0.0361
Schistosoma mansoni tar DNA-binding protein 0.0206 0.0456 0.0454
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0161 0.0347 0.0347
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0161 0.0347 0.0347
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0161 0.0347 0.0346
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0161 0.0347 0.0347
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0078 0.0146 0.0144
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0161 0.0347 0.0346
Onchocerca volvulus 0.0161 0.0347 0.0868
Mycobacterium tuberculosis Probable oxidoreductase 0.0137 0.0289 0.1104
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0161 0.0347 0.0347
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0167 0.0362 0.0361
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0161 0.0347 0.0346
Loa Loa (eye worm) hypothetical protein 0.006 0.0101 0.0101
Onchocerca volvulus 0.0161 0.0347 0.0868
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0074 0.0135 0.0134
Loa Loa (eye worm) calpain 5 0.0022 0.0009 0.0009
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0019 0.0002 0.0013
Loa Loa (eye worm) hypothetical protein 0.0167 0.0362 0.0362
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0016 0.1632
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.1579 0.379 1
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0141 0.0299 0.0297
Schistosoma mansoni ap endonuclease 0.0039 0.0051 0.0049
Leishmania major hypothetical protein, conserved 0.0025 0.0016 0.0137
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0023 0.0125
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0161 0.0347 0.0347
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0161 0.0347 0.0346
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.1579 0.379 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0002 0.0013
Onchocerca volvulus 4.1 G protein, putative homolog 0.0161 0.0347 0.0868
Echinococcus multilocularis geminin 0.0205 0.0453 0.0451
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0171 0.0372 0.037
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0022 0.0009 0.0081
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0161 0.0347 0.0347
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0002 0.0013
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0028 0.0023 0.0061
Loa Loa (eye worm) hypothetical protein 0.0161 0.0347 0.0347
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0051 0.0131
Echinococcus multilocularis transferase 0.0026 0.002 0.0018
Loa Loa (eye worm) hypothetical protein 0.0074 0.0135 0.0135
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0002 0.0013
Loa Loa (eye worm) hypothetical protein 0.0161 0.0347 0.0347
Echinococcus multilocularis tar DNA binding protein 0.0206 0.0456 0.0454
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0051 0.0448
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0023 0.0205
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.4137 1 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0022 0.0009 0.0081
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0171 0.0372 0.037
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0161 0.0347 0.0346
Echinococcus multilocularis gpi ethanolamine phosphate transferase 1 0.0026 0.002 0.0018
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0023 0.0061
Onchocerca volvulus 0.0161 0.0347 0.0868
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0043 0.0043
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0161 0.0347 0.0347
Brugia malayi calpain family protein 1 0.0074 0.0135 0.0135
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0161 0.0347 0.0346
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0106 0.0213 0.0211
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0161 0.0347 0.0346
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0022 0.0009 0.0081
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0487 0.1138 0.2999
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0106 0.0213 0.0211
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0161 0.0347 0.305
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0006
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0161 0.0347 0.0347
Trypanosoma brucei calpain-like protein, putative 0.0022 0.0009 0.0081
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0161 0.0347 0.0346
Brugia malayi hypothetical protein 0.0161 0.0347 0.0347
Echinococcus granulosus neuropeptide s receptor 0.0476 0.1112 0.1111
Loa Loa (eye worm) calpain family protein 1 0.0074 0.0135 0.0135
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0002 0.0013
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.1579 0.379 1
Brugia malayi Protein-tyrosine phosphatase 1 0.0161 0.0347 0.0347
Mycobacterium tuberculosis Probable dehydrogenase 0.0123 0.0256 0.0975
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0161 0.0347 0.0346
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0161 0.0347 0.0346
Loa Loa (eye worm) hypothetical protein 0.0161 0.0347 0.0347
Leishmania major tyrosine specific protein phosphatase, putative 0.0161 0.0347 0.305
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0051 0.0448
Brugia malayi calpain 7 0.0022 0.0009 0.0009
Schistosoma mansoni hypothetical protein 0.0078 0.0146 0.0144
Loa Loa (eye worm) hypothetical protein 0.0161 0.0347 0.0347
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0171 0.0372 0.037
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0161 0.0347 0.305
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0161 0.0347 0.0347
Schistosoma mansoni tar DNA-binding protein 0.0206 0.0456 0.0454
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0171 0.0372 0.037
Loa Loa (eye worm) hypothetical protein 0.0167 0.0362 0.0362
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0161 0.0347 0.0347
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0022 0.0009 0.0081
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0167 0.0362 0.0361
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.1579 0.379 0.379
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.1579 0.379 0.379
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0167 0.0362 0.0361
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0161 0.0347 0.0346
Brugia malayi Protein-tyrosine phosphatase 0.033 0.0758 0.0758
Onchocerca volvulus 0.0161 0.0347 0.0868
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0023 0.0061
Plasmodium falciparum thioredoxin reductase 0.0054 0.0087 1
Onchocerca volvulus 0.0161 0.0347 0.0868
Echinococcus granulosus tar DNA binding protein 0.0206 0.0456 0.0454
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0161 0.0347 0.0347
Brugia malayi hypothetical protein 0.0161 0.0347 0.0347
Echinococcus granulosus Endonuclease G 0.0101 0.02 0.0199
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0006
Trypanosoma brucei endonuclease G, putative 0.0101 0.02 0.1759
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0161 0.0347 0.0346
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0206 0.0456 0.0456
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0051 0.0049
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.4137 1 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0171 0.0372 0.037
Echinococcus granulosus transferase 0.0026 0.002 0.0018
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0022 0.0009 0.0081
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0106 0.0213 0.0213
Loa Loa (eye worm) hypothetical protein 0.0159 0.0342 0.0342
Onchocerca volvulus 0.0052 0.0082 0.0164
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0161 0.0347 0.0346
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0161 0.0347 0.0347
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.1579 0.379 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0161 0.0347 0.0347
Giardia lamblia Phosphatidylinositol-glycan biosynthesis, class O protein 0.0026 0.002 0.0049
Echinococcus multilocularis calpain A 0.0078 0.0144 0.0143
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.0026 0.002 0.002
Loa Loa (eye worm) TAR-binding protein 0.0206 0.0456 0.0456
Echinococcus granulosus ectonucleotide 0.0141 0.0299 0.0297
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.1579 0.379 1
Leishmania major kinesin, putative 0.0022 0.0009 0.0081
Trypanosoma cruzi trypanothione reductase, putative 0.0019 0.0002 0.0013
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0137 0.0289 1
Echinococcus multilocularis calpain 5 0.0022 0.0009 0.0008
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0161 0.0347 0.0893
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.1092 0.2608 1
Trypanosoma brucei trypanothione reductase 0.0054 0.0087 0.0768
Toxoplasma gondii exonuclease III APE 0.0039 0.0051 0.249
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0101 0.01
Trypanosoma brucei endonuclease G, putative 0.0101 0.02 0.1759
Onchocerca volvulus 0.0161 0.0347 0.0868
Echinococcus granulosus protein tyrosine phosphatase n9 0.0161 0.0347 0.0346
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0002 0.0013
Trypanosoma brucei protein tyrosine phosphatase 1 0.0161 0.0347 0.305
Leishmania major endonuclease G, putative 0.0101 0.02 0.1759
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0161 0.0347 0.0347
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0002 0.0013
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.0101 0.02 0.1759
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0106 0.0213 0.0213
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0023 0.0037
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0051 0.0131
Brugia malayi glutathione reductase 0.0054 0.0087 0.0087
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0023 0.0023
Schistosoma mansoni hypothetical protein 0.0036 0.0043 0.0041
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0417 0.0968 0.0968
Entamoeba histolytica phosphatidylinositol-glycan biosynthesis class O protein, putative 0.0026 0.002 0.0028
Brugia malayi Pre-SET motif family protein 0.006 0.0101 0.0101
Schistosoma mansoni tar DNA-binding protein 0.0206 0.0456 0.0454
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0161 0.0347 0.0346
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0006
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0006 1
Onchocerca volvulus 0.0161 0.0347 0.0868
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0167 0.0362 0.0361
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0167 0.0362 0.0361
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0161 0.0347 0.0346
Schistosoma mansoni protein tyrosine phosphatase 0.0171 0.0372 0.037
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0023 0.0023
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0002 0.0013
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0051 0.019
Loa Loa (eye worm) hypothetical protein 0.0028 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0036 0.0043 0.0043
Echinococcus granulosus calpain A 0.0078 0.0144 0.0143
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0161 0.0347 0.0347
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0083 0.0083
Schistosoma mansoni hypothetical protein 0.0026 0.002 0.0018
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0002 0.0013
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0026 0.002 0.0018
Brugia malayi hypothetical protein 0.0025 0.0016 0.0016
Entamoeba histolytica protein tyrosine phosphatase, putative 0.1579 0.379 1
Brugia malayi Thioredoxin reductase 0.0054 0.0087 0.0087
Echinococcus multilocularis calpain family protein 1, d 0.0052 0.0082 0.008
Onchocerca volvulus 0.0161 0.0347 0.0868
Loa Loa (eye worm) calpain 0.0022 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0161 0.0347 0.0347
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0106 0.0213 0.0211
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0019 0.0002 0.0013
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0161 0.0347 0.0346
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0161 0.0347 0.0346
Trypanosoma brucei kinesin, putative 0.0022 0.0009 0.0081
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0161 0.0347 0.0347
Onchocerca volvulus 0.0161 0.0347 0.0868
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0161 0.0347 0.0346
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.2334 0.2332
Loa Loa (eye worm) calpain family protein 1 0.0052 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.032 0.0733 0.0733
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0078 0.0144 0.0143
Loa Loa (eye worm) hypothetical protein 0.0161 0.0347 0.0347
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0161 0.0347 0.0346
Loa Loa (eye worm) hypothetical protein 0.0141 0.0299 0.0299
Leishmania major trypanothione reductase 0.0054 0.0087 0.0768
Loa Loa (eye worm) hypothetical protein 0.0074 0.0135 0.0135
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0028 0.0023 0.0061
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0161 0.0347 0.0347
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0006 0.0017
Loa Loa (eye worm) hypothetical protein 0.0161 0.0347 0.0347
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0167 0.0362 0.0361
Schistosoma mansoni calpain C (C02 family) 0.0022 0.0009 0.0008
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0171 0.0372 0.037
Onchocerca volvulus 0.0161 0.0347 0.0868
Trypanosoma brucei calpain-like protein, putative 0.0022 0.0009 0.0081
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0106 0.0213 0.0211
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0161 0.0347 0.305
Echinococcus granulosus neuropeptide receptor A26 0.0476 0.1112 0.1111
Trypanosoma brucei antigen, putative 0.0022 0.0009 0.0081
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0023 0.0205
Echinococcus multilocularis calpain 7 (C02 family) 0.0022 0.0009 0.0008
Brugia malayi RNA recognition motif domain containing protein 0.0206 0.0456 0.0456
Brugia malayi calpain family protein 1 0.0074 0.0135 0.0135
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0161 0.0347 0.0346
Loa Loa (eye worm) hypothetical protein 0.0161 0.0347 0.0347
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0123 0.0256 0.0975
Echinococcus granulosus geminin 0.0205 0.0453 0.0451
Onchocerca volvulus 0.0161 0.0347 0.0868
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0016 0.0137
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0161 0.0347 0.0347
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0051 0.0131
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0171 0.0372 0.037
Mycobacterium tuberculosis Probable reductase 0.0123 0.0256 0.0975
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0137 0.0289 0.1104
Schistosoma mansoni protein tyrosine phosphatase 0.0161 0.0347 0.0346
Brugia malayi Thrombospondin type 1 domain containing protein 0.0361 0.0834 0.0834
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0161 0.0347 0.0346
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0161 0.0347 0.0346
Brugia malayi hypothetical protein 0.0161 0.0347 0.0347
Onchocerca volvulus 0.0169 0.0367 0.0921
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0106 0.0213 0.0211
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0022 0.0009 0.0081
Onchocerca volvulus 0.0361 0.0834 0.2158
Schistosoma mansoni hypothetical protein 0.0205 0.0453 0.0451
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0023 0.0083
Onchocerca volvulus 0.0161 0.0347 0.0868
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0161 0.0347 0.0347
Schistosoma mansoni Mername-AA248 (C02 family) 0.0022 0.0009 0.0008
Plasmodium vivax SET domain protein, putative 0.006 0.0101 1
Brugia malayi TAR-binding protein 0.0206 0.0456 0.0456
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0023 0.0037
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0023 0.0061
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0022 0.0009 0.0081
Loa Loa (eye worm) hypothetical protein 0.0167 0.0362 0.0362
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0078 0.0144 0.0143
Brugia malayi endonuclease G, mitochondrial precursor 0.0101 0.02 0.02
Trypanosoma brucei endonuclease G, putative 0.0101 0.02 0.1759
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0161 0.0347 0.0347
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0051 0.0051
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0078 0.0146 0.0144
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0161 0.0347 0.0347
Loa Loa (eye worm) hypothetical protein 0.0161 0.0347 0.0347
Loa Loa (eye worm) hypothetical protein 0.0026 0.002 0.002
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0161 0.0347 0.305
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0101 0.01
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0161 0.0347 0.0346
Trypanosoma brucei calpain-like protein, putative 0.0022 0.0009 0.0081
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0016 0.1632
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0161 0.0347 0.0347
Loa Loa (eye worm) hypothetical protein 0.0052 0.0083 0.0083
Brugia malayi AEL166Cp 0.0026 0.002 0.002
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0022 0.0009 0.0081
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0028 0.0023 0.0083
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0137 0.0289 0.1104
Loa Loa (eye worm) hypothetical protein 0.0026 0.002 0.002
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0161 0.0347 0.0347
Echinococcus multilocularis thioredoxin glutathione reductase 0.0054 0.0087 0.0086
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0026 0.002 0.0018
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0123 0.0256 0.0975
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0161 0.0347 0.0347
Echinococcus granulosus thioredoxin glutathione reductase 0.0054 0.0087 0.0086
Loa Loa (eye worm) hypothetical protein 0.0161 0.0347 0.0347
Trichomonas vaginalis set domain proteins, putative 0.0474 0.1108 0.2921
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0026 0.002 0.0018
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0022 0.0009 0.0081
Loa Loa (eye worm) hypothetical protein 0.0161 0.0347 0.0347
Loa Loa (eye worm) hypothetical protein 0.0161 0.0347 0.0347
Entamoeba histolytica hypothetical protein 0.0078 0.0146 0.0362
Onchocerca volvulus 0.006 0.0101 0.0216
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0161 0.0347 0.0347
Entamoeba histolytica phosphatidylinositol-glycan biosynthesis class O protein, putative 0.0026 0.002 0.0028
Schistosoma mansoni pcd6 interacting protein-related 0.0161 0.0347 0.0346
Brugia malayi hypothetical protein 0.0026 0.002 0.002
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0161 0.0347 0.0346
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0023 0.0125
Entamoeba histolytica acyl-coA synthetase, putative 0.0028 0.0023 0.0037
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0101 0.5016
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0023 0.0023
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0051 0.0049
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0016 0.0705
Loa Loa (eye worm) protein tyrosine phosphatase 0.0161 0.0347 0.0347
Schistosoma mansoni endonuclease related 0.0101 0.02 0.0199
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0161 0.0347 0.0347
Echinococcus multilocularis neuropeptide receptor A26 0.0476 0.1112 0.1111
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0167 0.0362 0.0361
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0161 0.0347 0.0347
Onchocerca volvulus 0.0161 0.0347 0.0868
Leishmania major ethanolamine phosphotransferase, putative 0.0026 0.002 0.0175
Loa Loa (eye worm) thioredoxin reductase 0.0054 0.0087 0.0087
Schistosoma mansoni hypothetical protein 0.0026 0.002 0.0018
Loa Loa (eye worm) hypothetical protein 0.0028 0.0023 0.0023
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0161 0.0347 0.0347
Schistosoma mansoni tar DNA-binding protein 0.0206 0.0456 0.0454
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0161 0.0347 0.0347
Loa Loa (eye worm) hypothetical protein 0.0161 0.0347 0.0347
Loa Loa (eye worm) hypothetical protein 0.0161 0.0347 0.0347
Onchocerca volvulus 0.0161 0.0347 0.0868
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0023 0.0205
Onchocerca volvulus 0.0161 0.0347 0.0868
Schistosoma mansoni protein tyrosine phosphatase 0.0161 0.0347 0.0346
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0006 0.0476
Onchocerca volvulus 0.0161 0.0347 0.0868
Loa Loa (eye worm) hypothetical protein 0.0159 0.0342 0.0342
Loa Loa (eye worm) hypothetical protein 0.0161 0.0347 0.0347
Onchocerca volvulus 0.0161 0.0347 0.0868
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0019 0.0002 0.0013
Echinococcus multilocularis ectonucleotide 0.0141 0.0299 0.0297
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0161 0.0347 0.0346
Loa Loa (eye worm) hypothetical protein 0.0161 0.0347 0.0347
Echinococcus granulosus histone lysine methyltransferase setb 0.006 0.0101 0.01
Trypanosoma cruzi endonuclease G, putative 0.0101 0.02 0.1759
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0161 0.0347 0.0346
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0019 0.0002 0.0013
Loa Loa (eye worm) hypothetical protein 0.0052 0.0082 0.0082
Brugia malayi calpain 5 0.0022 0.0009 0.0009
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0161 0.0347 0.0346
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0078 0.0144 0.0143
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0019 0.0002 0.0004
Schistosoma mansoni tar DNA-binding protein 0.0206 0.0456 0.0454
Plasmodium vivax glutathione reductase, putative 0.0054 0.0087 0.8619
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.0167 0.0362 0.0362
Plasmodium vivax calpain, putative 0.0022 0.0009 0.0776
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0123 0.0256 0.8758
Trypanosoma brucei GPI ethanolamine phosphate transferase 3, putative 0.0026 0.002 0.0175
Echinococcus multilocularis calpain 0.0022 0.0009 0.0008
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0161 0.0347 0.0347
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0022 0.0009 0.0081
Echinococcus multilocularis hypothetical protein 0.0022 0.0009 0.0008
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0002 0.0013
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0161 0.0347 0.0347
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0161 0.0347 0.0347
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0161 0.0347 0.0346
Onchocerca volvulus 0.0161 0.0347 0.0868
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0054 0.0087 0.0329
Onchocerca volvulus 0.0167 0.0362 0.0909
Loa Loa (eye worm) hypothetical protein 0.0161 0.0347 0.0347
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0487 0.1138 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0051 1
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0022 0.0009 0.0081
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0016 0.0137
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0161 0.0347 0.0346
Onchocerca volvulus 0.0161 0.0347 0.0868
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0171 0.0372 0.037
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0022 0.0009 0.0081
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0161 0.0347 0.0346
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0028 0.0023 0.0061
Onchocerca volvulus 0.0028 0.0023 0.0009
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0161 0.0347 0.0347
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0004 0.0008
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0016 0.1406
Loa Loa (eye worm) hypothetical protein 0.0161 0.0347 0.0347
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0167 0.0362 0.0361
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0019 0.0002 0.0004
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0487 0.1138 0.2999
Echinococcus granulosus calpain A 0.0022 0.0009 0.0008
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0051 1
Schistosoma mansoni ap endonuclease 0.0039 0.0051 0.0049
Echinococcus multilocularis Alkaline phosphatase, core domain 0.0026 0.002 0.0018
Trichomonas vaginalis pten, drome, putative 0.0161 0.0347 0.0912
Giardia lamblia Protein tyrosine phosphatase 0.0161 0.0347 0.0912
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0101 0.01
Loa Loa (eye worm) hypothetical protein 0.0161 0.0347 0.0347
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0161 0.0347 0.0893
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0171 0.0372 0.037
Toxoplasma gondii DNA/RNA non-specific endonuclease 0.0101 0.02 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0004 0.0008
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0161 0.0347 0.0347
Echinococcus multilocularis Endonuclease G 0.0101 0.02 0.0199
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0167 0.0362 0.0361
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0161 0.0347 0.0347
Schistosoma mansoni hypothetical protein 0.0026 0.002 0.0018
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0083 0.0083
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.1579 0.379 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.0101 0.01
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0161 0.0347 0.0346
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0006 0.0018
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0078 0.0144 0.0143
Onchocerca volvulus 0.0161 0.0347 0.0868
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0051 0.0135
Echinococcus multilocularis hypothetical protein 0.0161 0.0347 0.0346
Schistosoma mansoni hypothetical protein 0.0205 0.0453 0.0451
Loa Loa (eye worm) hypothetical protein 0.0182 0.0399 0.0399
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0161 0.0347 0.0346
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0161 0.0347 0.0347
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0171 0.0372 0.037
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0026 0.002 0.0018
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0161 0.0347 0.0346
Plasmodium falciparum GPI ethanolamine phosphate transferase 3, putative 0.0026 0.002 0.2142
Onchocerca volvulus 0.0167 0.0362 0.0909
Loa Loa (eye worm) hypothetical protein 0.0052 0.0082 0.0082
Brugia malayi hypothetical protein 0.0161 0.0347 0.0347
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0101 0.01
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0002 0.0013
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0022 0.0009 0.0081
Trypanosoma cruzi kinesin, putative 0.0022 0.0009 0.0081
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0167 0.0362 0.0361
Schistosoma mansoni hypothetical protein 0.0026 0.002 0.0018
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0171 0.0372 0.037
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0106 0.0213 0.0211
Brugia malayi Pre-SET motif family protein 0.0417 0.0968 0.0968
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.0161 0.0347 0.0893
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.4137 1 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0161 0.0347 0.0347
Entamoeba histolytica hypothetical protein 0.0078 0.0146 0.0362
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0123 0.0256 0.0975
Loa Loa (eye worm) RNA binding protein 0.0206 0.0456 0.0456
Loa Loa (eye worm) thrombospondin type 1 domain-containing protein 0.0361 0.0834 0.0834
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0106 0.0213 0.0211
Entamoeba histolytica protein tyrosine phosphatase, putative 0.1579 0.379 1
Loa Loa (eye worm) type I phosphodiesterase/nucleotide pyrophosphatase 0.0026 0.002 0.002
Trypanosoma cruzi trypanothione reductase, putative 0.0054 0.0087 0.0768
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0171 0.0372 0.037
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0002 0.0013
Loa Loa (eye worm) hypothetical protein 0.0161 0.0347 0.0347
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0006
Trypanosoma brucei calpain-like protein, putative 0.0022 0.0009 0.0081
Plasmodium falciparum glutathione reductase 0.0054 0.0087 1
Echinococcus granulosus calpain 5 0.0022 0.0009 0.0008
Schistosoma mansoni calpain-7 (C02 family) 0.0022 0.0009 0.0008
Echinococcus multilocularis gpi ethanolamine phosphate transferase 3 0.0026 0.002 0.0018
Loa Loa (eye worm) hypothetical protein 0.0161 0.0347 0.0347
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0167 0.0362 0.0361
Schistosoma mansoni calpain (C02 family) 0.0022 0.0009 0.0008
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.0023 0.0061

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0052 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.6611 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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