Detailed information for compound 1551866

Basic information

Technical information
  • TDR Targets ID: 1551866
  • Name: 4-methyl-N-[2-[2-(4-methylphenoxy)ethylamino] -2-oxoethyl]benzamide
  • MW: 326.39 | Formula: C19H22N2O3
  • H donors: 2 H acceptors: 2 LogP: 2.94 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CNC(=O)c1ccc(cc1)C)NCCOc1ccc(cc1)C
  • InChi: 1S/C19H22N2O3/c1-14-3-7-16(8-4-14)19(23)21-13-18(22)20-11-12-24-17-9-5-15(2)6-10-17/h3-10H,11-13H2,1-2H3,(H,20,22)(H,21,23)
  • InChiKey: ZWBDNBULTFIBDM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-methyl-N-[2-[2-(4-methylphenoxy)ethylamino]-2-oxo-ethyl]benzamide
  • N-[2-keto-2-[2-(4-methylphenoxy)ethylamino]ethyl]-4-methyl-benzamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Cathepsin B precursor 0.0097 0.1039 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0054 0.017
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0007 0.0021 0.0546
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0021 0.0068
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0054 0.017
Brugia malayi cathepsin Z-like cysteine proteinase 0.0012 0.0081 0.0254
Brugia malayi Patched family protein 0.0006 0.001 0.0031
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0012 0.0081 0.0254
Loa Loa (eye worm) patched family protein 0.0006 0.001 0.0031
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0054 0.0054
Echinococcus multilocularis cathepsin L 0.002 0.0162 0.0162
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0012 0.0081 0.4653
Loa Loa (eye worm) hypothetical protein 0.0006 0.001 0.0031
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0219 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0041 0.0041
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0162 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0148 0.0466
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0507 0.1594
Plasmodium falciparum serine repeat antigen 8 0.0012 0.0081 0.4653
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0054 0.017
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0155 0.0155
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0081 0.0223
Loa Loa (eye worm) hypothetical protein 0.0019 0.0155 0.0487
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0162 0.051
Loa Loa (eye worm) hypothetical protein 0.001 0.0054 0.017
Brugia malayi Cathepsin L-like cysteine proteinase 0.0012 0.0081 0.0254
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0054 0.017
Entamoeba histolytica cysteine protease, putative 0.002 0.0162 0.1305
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0162 0.1305
Loa Loa (eye worm) hypothetical protein 0.0006 0.001 0.0031
Entamoeba histolytica cysteine protease, putative 0.002 0.0162 0.1305
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.002 0.0162 0.051
Loa Loa (eye worm) hypothetical protein 0.0012 0.0081 0.0254
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0054 0.017
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0162 0.1305
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0155 0.0487
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0007 0.0021 0.0767
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0012 0.0081 0.0254
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0054 0.017
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0006 0.0003 0.0011
Entamoeba histolytica cysteine protease, putative 0.002 0.0162 0.1305
Brugia malayi Papain family cysteine protease containing protein 0.0012 0.0081 0.0254
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0054 0.017
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0054 0.017
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0162 0.0447
Echinococcus granulosus cathepsin l1 0.002 0.0162 0.051
Loa Loa (eye worm) hypothetical protein 0.001 0.0054 0.017
Onchocerca volvulus 0.002 0.0162 0.0558
Loa Loa (eye worm) hypothetical protein 0.0006 0.001 0.0031
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0621 0.1952
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0219 1
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0054 0.017
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0286 0.318 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0299 0.2812
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.002 0.0162 0.051
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.002 0.0162 0.1383
Echinococcus granulosus GPCR family 2 0.0019 0.0155 0.0487
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.002 0.0162 0.1383
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0012 0.0081 0.4653
Echinococcus multilocularis cathepsin L 0.0012 0.0081 0.0081
Echinococcus granulosus Niemann Pick C1 protein 0.0103 0.1101 0.3461
Onchocerca volvulus 0.002 0.0162 0.0558
Brugia malayi Patched family protein 0.0006 0.001 0.0031
Entamoeba histolytica cysteine protease, putative 0.0012 0.0081 0.0549
Schistosoma mansoni cathepsin S (C01 family) 0.0012 0.0081 0.0254
Loa Loa (eye worm) hypothetical protein 0.0006 0.001 0.0031
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0438 0.0438
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0054 0.017
Loa Loa (eye worm) hypothetical protein 0.0006 0.001 0.0031
Brugia malayi Patched family protein 0.0006 0.001 0.0031
Entamoeba histolytica cysteine protease, putative 0.0012 0.0081 0.0549
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0012 0.0081 0.2451
Loa Loa (eye worm) hypothetical protein 0.0012 0.0081 0.0254
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0054 0.017
Echinococcus granulosus cathepsin L 0.0012 0.0081 0.0254
Brugia malayi Patched related family protein 12 0.0006 0.001 0.0031
Leishmania major cathepsin L-like protease 0.002 0.0162 0.1383
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0162 0.0522
Onchocerca volvulus 0.002 0.0162 0.0558
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0148 0.6617
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0054 0.0054
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0054 0.017
Echinococcus granulosus cathepsin b 0.0286 0.318 1
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0219 0.0689
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0012 0.0081 0.0254
Loa Loa (eye worm) hypothetical protein 0.006 0.0621 0.1952
Schistosoma mansoni cpg binding protein 0.0031 0.0296 0.093
Loa Loa (eye worm) hypothetical protein 0.0103 0.1101 0.3461
Loa Loa (eye worm) patched family protein 0.0006 0.001 0.0031
Brugia malayi Cathepsin L-like precursor 0.0012 0.0081 0.0254
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0162 0.051
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0007 0.0021 0.0114
Loa Loa (eye worm) hypothetical protein 0.0018 0.0148 0.0466
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0299 0.0941
Loa Loa (eye worm) hypothetical protein 0.0012 0.0081 0.0254
Loa Loa (eye worm) oxidoreductase 0.0007 0.0021 0.0068
Brugia malayi Patched family protein 0.0006 0.001 0.0031
Schistosoma mansoni acetyl-CoA synthetase 0.0007 0.0021 0.0068
Loa Loa (eye worm) hypothetical protein 0.0054 0.055 0.1729
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0219 0.1941
Echinococcus multilocularis cysteine protease 0.002 0.0162 0.0162
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0012 0.0081 0.0223
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0054 0.017
Onchocerca volvulus 0.0007 0.0021 0.0043
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0007 0.0021 0.0114
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0219 1
Echinococcus granulosus cathepsin l1 0.0012 0.0081 0.0254
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0162 0.0522
Brugia malayi Patched family protein 0.0006 0.001 0.0031
Loa Loa (eye worm) hypothetical protein 0.0007 0.0021 0.0066
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0021 0.0002
Loa Loa (eye worm) hypothetical protein 0.0006 0.001 0.0031
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0012 0.0081 0.0254
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0012 0.0081 0.4653
Loa Loa (eye worm) hypothetical protein 0.0006 0.001 0.0031
Entamoeba histolytica hypothetical protein 0.0012 0.0081 0.0549
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0137 0.6071
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0054 0.0054
Loa Loa (eye worm) patched family protein 0.0006 0.001 0.0031
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0012 0.0081 0.0223
Loa Loa (eye worm) hypothetical protein 0.0006 0.001 0.0031
Plasmodium falciparum cysteine proteinase falcipain 1 0.002 0.0162 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.001 0.0031
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0279 0.0876
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0012 0.0081 0.2451
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0054 0.017
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0012 0.0081 0.0254
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0021 0.0068
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0041 0.0128
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0054 0.017
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0054 0.017
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0012 0.0081 0.0223
Brugia malayi cathepsin F-like cysteine proteinase 0.0012 0.0081 0.0254
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0218 0.2402 0.7554
Brugia malayi hypothetical protein 0.0006 0.001 0.0031
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0162 0.0522
Loa Loa (eye worm) hypothetical protein 0.0006 0.001 0.0031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0162 0.0522
Brugia malayi Patched related family protein 10 0.0006 0.001 0.0031
Entamoeba histolytica cysteine protease, putative 0.002 0.0162 0.1305
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0041 0.0041
Brugia malayi Patched family protein 0.0006 0.001 0.0031
Trypanosoma cruzi major cysteine proteinase, putative 0.0012 0.0081 0.0189
Loa Loa (eye worm) hypothetical protein 0.0006 0.001 0.0031
Schistosoma mansoni hypothetical protein 0.0019 0.0155 0.0487
Brugia malayi protein C24B5.3 0.0006 0.001 0.0031
Entamoeba histolytica cysteine proteinase, putative 0.0012 0.0081 0.0549
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0162 0.0522
Leishmania major cathepsin L-like protease 0.002 0.0162 0.1383
Onchocerca volvulus Cathepsin L homolog 0.002 0.0162 0.0558
Brugia malayi Cathepsin L-like precursor 0.0012 0.0081 0.0254
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0438 0.1535
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0081 0.0223
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0219 1
Plasmodium falciparum serine repeat antigen 5 0.0012 0.0081 0.4653
Trypanosoma cruzi cysteine protease, putative 0.002 0.0162 0.0447
Loa Loa (eye worm) hypothetical protein 0.0286 0.318 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0162 0.0162
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0162 0.0522
Onchocerca volvulus 0.0012 0.0081 0.026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0081 0.0223
Brugia malayi hypothetical protein 0.0006 0.001 0.0031
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0286 0.318 1
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0054 0.017
Brugia malayi Patched family protein 0.0006 0.001 0.0031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0162 0.0522
Trypanosoma cruzi cysteine proteinase, putative 0.002 0.0162 0.0447
Entamoeba histolytica cysteine protease, putative 0.002 0.0162 0.1305
Loa Loa (eye worm) hypothetical protein 0.0012 0.0081 0.0254
Echinococcus granulosus cathepsin L 0.002 0.0162 0.051
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0012 0.0081 0.0254
Trypanosoma cruzi cruzipain precursor, putative 0.002 0.0162 0.0447
Trypanosoma cruzi cysteine proteinase, putative 0.002 0.0162 0.0447
Plasmodium vivax vivapain-1 0.002 0.0162 0.5267
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0012 0.0081 0.0549
Brugia malayi Cathepsin L-like precursor 0.0007 0.0021 0.0066
Schistosoma mansoni patched 1 0.0044 0.0438 0.1377
Brugia malayi cathepsin L precursor 0.0012 0.0081 0.0254
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0054 0.017
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0507 0.1594
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0063 0.0063
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.002 0.0162 0.1383
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0012 0.0081 0.0189
Loa Loa (eye worm) hypothetical protein 0.0006 0.001 0.0031
Schistosoma mansoni thyroid hormone receptor 0.001 0.0054 0.017
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0162 0.051
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0097 0.1039 0.3745
Brugia malayi Patched family protein 0.0006 0.001 0.0031
Loa Loa (eye worm) hypothetical protein 0.001 0.0054 0.017
Echinococcus granulosus cathepsin b 0.0286 0.318 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0012 0.0081 0.0254
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0012 0.0081 0.0223
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0012 0.0081 0.2451
Echinococcus granulosus cpg binding protein 0.0033 0.0316 0.0994
Plasmodium falciparum serine repeat antigen 1 0.0012 0.0081 0.4653
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0162 0.0522
Brugia malayi Cathepsin L-like precursor 0.002 0.0162 0.051
Echinococcus granulosus Niemann Pick C1 protein 0.0147 0.1599 0.5029
Loa Loa (eye worm) hypothetical protein 0.0006 0.001 0.0031
Brugia malayi ecdysteroid receptor 0.001 0.0054 0.017
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0137 0.6071
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0162 0.1305
Leishmania major cysteine peptidase A (CPA) 0.002 0.0162 0.1383
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0162 0.0522
Plasmodium vivax serine-repeat antigen (SERA) 0.0012 0.0081 0.2451
Mycobacterium ulcerans hypothetical protein 0.0025 0.0219 1
Plasmodium vivax unspecified product 0.0012 0.0081 0.2451
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0054 0.0162
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.002 0.0162 0.1383
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0021 0.0068
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0081 0.0223
Loa Loa (eye worm) hypothetical protein 0.0025 0.0219 0.0689
Loa Loa (eye worm) hypothetical protein 0.0018 0.0148 0.0466
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0012 0.0081 0.0254
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0162 0.051
Plasmodium vivax acetyl-CoA synthetase, putative 0.0007 0.0021 0.0404
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0219 1
Onchocerca volvulus 0.0007 0.0021 0.0043
Brugia malayi Patched family protein 0.0006 0.001 0.0031
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0162 0.0162
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0007 0.0021 0.0546
Schistosoma mansoni hypothetical protein 0.0019 0.0155 0.0487
Loa Loa (eye worm) cathepsin B 0.0097 0.1039 0.3268
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0041 0.0128
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0162 0.0447
Plasmodium falciparum serine repeat antigen 9 0.0012 0.0081 0.4653
Loa Loa (eye worm) hypothetical protein 0.0006 0.001 0.0031
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0162 0.0522
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0054 0.0054
Plasmodium vivax vivapain-3 0.002 0.0162 0.5267
Brugia malayi Patched family protein 0.0006 0.001 0.0031
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0021 0.0002
Plasmodium falciparum serine repeat antigen 4 0.0012 0.0081 0.4653
Brugia malayi cathepsin B-like cysteine proteinase 0.0286 0.318 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0081 0.0223
Loa Loa (eye worm) hypothetical protein 0.0006 0.001 0.0031
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.002 0.0162 0.1383
Echinococcus multilocularis cathepsin b 0.0286 0.318 0.318
Onchocerca volvulus 0.002 0.0162 0.0558
Schistosoma mansoni hypothetical protein 0.0019 0.0155 0.0487
Plasmodium falciparum serine repeat antigen 2 0.0012 0.0081 0.4653
Brugia malayi Cathepsin L-like precursor 0.002 0.0162 0.051
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0162 0.0162
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0063 0.0197
Onchocerca volvulus 0.0007 0.0021 0.0043
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0162 0.051
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0021 0.0546
Brugia malayi Pre-SET motif family protein 0.0218 0.2402 0.7554
Onchocerca volvulus Cathepsin L homolog 0.002 0.0162 0.0558
Loa Loa (eye worm) hypothetical protein 0.0006 0.001 0.0031
Leishmania major cathepsin L-like protease 0.002 0.0162 0.1383
Toxoplasma gondii propionate-CoA ligase 0.0007 0.0021 0.0114
Loa Loa (eye worm) hypothetical protein 0.0012 0.0081 0.0254
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0097 0.1039 0.3268
Entamoeba histolytica cysteine protease, putative 0.0012 0.0081 0.0549
Brugia malayi fibroinase precursor 0.0012 0.0081 0.0254
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0007 0.0021 0.0546
Loa Loa (eye worm) hypothetical protein 0.0044 0.0438 0.1377
Brugia malayi Patched family protein 0.0006 0.001 0.0031
Schistosoma mansoni hypothetical protein 0.0019 0.0155 0.0487
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0012 0.0081 0.2451
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.002 0.0162 0.1383
Brugia malayi Patched family protein 0.0006 0.001 0.0031
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0148 0.5
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0162 0.051
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0063 0.0197
Loa Loa (eye worm) hypothetical protein 0.0006 0.001 0.0031
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0041 0.0128
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0219 0.183
Schistosoma mansoni hypothetical protein 0.0042 0.042 0.132
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0621 0.1952
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0438 0.1377
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0219 0.0689
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0155 0.0487
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0162 0.0522
Echinococcus granulosus expressed conserved protein 0.0096 0.103 0.324
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0006 0.001 0.0031
Toxoplasma gondii cathepsin CPL 0.002 0.0162 0.1481
Leishmania major cathepsin L-like protease 0.002 0.0162 0.1383
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0296 0.093
Entamoeba histolytica cysteine proteinase 1, putative 0.002 0.0162 0.1305
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0219 1
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0054 0.0162
Loa Loa (eye worm) hypothetical protein 0.0007 0.0021 0.0068
Plasmodium vivax unspecified product 0.0007 0.0021 0.0384
Echinococcus granulosus survival motor neuron protein 1 0.0246 0.2729 0.8581
Toxoplasma gondii cathepsin B 0.0097 0.1039 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0054 0.017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.002 0.0162 0.1383
Loa Loa (eye worm) ctsf protein 0.002 0.0162 0.051
Plasmodium vivax unspecified product 0.002 0.0162 0.5267
Echinococcus multilocularis GPCR, family 2 0.0019 0.0155 0.0155
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0012 0.0081 0.2451
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0162 0.0447
Loa Loa (eye worm) hypothetical protein 0.0007 0.0021 0.0066
Loa Loa (eye worm) hypothetical protein 0.0012 0.0081 0.0254
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0007 0.0021 0.0546
Entamoeba histolytica cysteine protease, putative 0.0012 0.0081 0.0549
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0007 0.0021 0.0068
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0012 0.0081 0.0223
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0286 0.318 1
Entamoeba histolytica cysteine protease, putative 0.0012 0.0081 0.0549
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0219 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0054 0.017
Loa Loa (eye worm) hypothetical protein 0.0012 0.0081 0.0254
Onchocerca volvulus 0.002 0.0162 0.0558
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0621 0.1952
Schistosoma mansoni hypothetical protein 0.0042 0.042 0.132
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0054 0.017
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0054 0.0054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0162 0.0522
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0081 0.0223
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0012 0.0081 0.2451
Loa Loa (eye worm) hypothetical protein 0.0025 0.0219 0.0689
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0148 0.4786
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0054 0.017
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0162 0.1305
Brugia malayi cathepsin L-like precursor 0.0012 0.0081 0.0254
Brugia malayi Patched related family protein 4 0.0006 0.001 0.0031
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0021 0.0546
Entamoeba histolytica cysteine protease, putative 0.002 0.0162 0.1305
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0021 0.0005
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0219 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0137 0.6071
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0162 0.051
Schistosoma mansoni cathepsin s 0.0007 0.0021 0.0066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0162 0.0522
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0054 0.017
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0054 0.017
Loa Loa (eye worm) hypothetical protein 0.0007 0.0021 0.0068
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.0081 0.0254
Brugia malayi hypothetical protein 0.0006 0.001 0.0031
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0219 0.1941
Schistosoma mansoni cpg binding protein 0.0033 0.0316 0.0994
Onchocerca volvulus 0.0248 0.2741 1
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0012 0.0081 0.2451
Loa Loa (eye worm) patched family protein 0.0006 0.001 0.0031
Onchocerca volvulus 0.005 0.0508 0.1825
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0054 0.017
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0012 0.0081 0.2451
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0103 0.1101 1
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0162 0.051
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0012 0.0081 0.0549
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0155 0.0487
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0054 0.0162
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0012 0.0081 0.0254
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0054 0.0054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0081 0.0223
Brugia malayi Papain family cysteine protease containing protein 0.0012 0.0081 0.0254
Loa Loa (eye worm) hypothetical protein 0.0006 0.001 0.0031
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0012 0.0081 0.2451
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0162 0.0162
Brugia malayi Patched protein homolog 1 0.0006 0.001 0.0031
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0054 0.017
Entamoeba histolytica cysteine protease, putative 0.002 0.0162 0.1305
Onchocerca volvulus 0.0032 0.0299 0.106
Plasmodium vivax vivapain-2 0.002 0.0162 0.5267
Loa Loa (eye worm) hypothetical protein 0.0025 0.0219 0.0689
Loa Loa (eye worm) hypothetical protein 0.0246 0.2729 0.8581
Brugia malayi Niemann-Pick C1 protein precursor 0.0103 0.1101 0.3461
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0162 0.0522
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0054 0.017
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0012 0.0081 0.0223
Loa Loa (eye worm) patched family protein 0.0006 0.001 0.0031
Loa Loa (eye worm) hypothetical protein 0.0006 0.001 0.0031
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0286 0.318 1
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0054 0.017
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0162 0.0447
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.002 0.0162 0.051
Echinococcus multilocularis Niemann Pick C1 protein 0.0147 0.1599 0.1599
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0054 0.0054
Trypanosoma cruzi major cysteine proteinase, putative 0.0012 0.0081 0.0189
Echinococcus multilocularis expressed conserved protein 0.0096 0.103 0.103
Loa Loa (eye worm) hypothetical protein 0.0018 0.0148 0.0466
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0219 1
Entamoeba histolytica cysteine protease, putative 0.002 0.0162 0.1305
Entamoeba histolytica cysteine protease, putative 0.002 0.0162 0.1305
Echinococcus multilocularis protein patched 0.0044 0.0438 0.0438
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0054 0.017
Onchocerca volvulus Cathepsin L homolog 0.0012 0.0081 0.026
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0007 0.0021 0.0066
Brugia malayi Papain family cysteine protease containing protein 0.0012 0.0081 0.0254
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0299 0.0941
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0054 0.017
Loa Loa (eye worm) hypothetical protein 0.0032 0.0299 0.0941
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0162 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0155 0.0487
Loa Loa (eye worm) hypothetical protein 0.0006 0.001 0.0031
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0097 0.1039 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0081 0.0223
Schistosoma mansoni thyroid hormone receptor 0.001 0.0054 0.017
Brugia malayi nuclear hormone receptor 0.001 0.0054 0.017
Onchocerca volvulus Cathepsin F homolog 0.002 0.0162 0.0558
Brugia malayi protein C24B5.3 0.0006 0.001 0.0031
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0162 0.0522
Echinococcus multilocularis Niemann Pick C1 protein 0.0103 0.1101 0.1101
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.002 0.0162 0.1383
Brugia malayi steroid hormone receptor 0.001 0.0054 0.017
Entamoeba histolytica cysteine protease, putative 0.002 0.0162 0.1305
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0054 0.017
Brugia malayi Cathepsin L-like precursor 0.002 0.0162 0.051
Giardia lamblia Cathepsin B precursor 0.0097 0.1039 1
Schistosoma mansoni cathepsin B (C01 family) 0.0012 0.0081 0.0254
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0162 0.0522
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0162 0.0522
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0162 0.0522
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0012 0.0081 0.0254
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.002 0.0162 0.1383
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0219 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0162 0.0522
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0507 0.1594
Toxoplasma gondii preprocathepsin c precursor, putative 0.0012 0.0081 0.0689
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0007 0.0021 0.0066
Loa Loa (eye worm) hypothetical protein 0.001 0.0054 0.017
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0162 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0012 0.0081 0.0254
Toxoplasma gondii cathepsin CPC2 0.0012 0.0081 0.0689
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0021 0.0005
Giardia lamblia Cathepsin B precursor 0.0097 0.1039 1
Schistosoma mansoni hypothetical protein 0.0042 0.042 0.132
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0054 0.017
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0299 0.0299
Brugia malayi nuclear receptor NHR-88 0.001 0.0054 0.017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0054 0.017
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0012 0.0081 0.0223
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0507 0.1594
Brugia malayi Cathepsin L-like precursor 0.002 0.0162 0.051
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0104 0.1119 0.3518
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0021 0.0068
Leishmania major cathepsin L-like protease 0.002 0.0162 0.1383
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0021 0.0546
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0162 0.0522
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0021 0.0068
Schistosoma mansoni survival motor neuron protein 0.005 0.0508 0.1598
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0162 0.0522
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0148 0.6421
Plasmodium falciparum serine repeat antigen 7 0.0012 0.0081 0.4653
Echinococcus granulosus cysteine protease 0.002 0.0162 0.051
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0219 0.183
Echinococcus multilocularis cathepsin b 0.0286 0.318 0.318
Loa Loa (eye worm) hypothetical protein 0.0006 0.001 0.0031
Brugia malayi cathepsin F-like cysteine proteinase 0.0007 0.0021 0.0066
Plasmodium vivax serine-repeat antigen (SERA) 0.0012 0.0081 0.2451
Brugia malayi Patched family protein 0.0006 0.001 0.0031
Brugia malayi Cathepsin L-like precursor 0.002 0.0162 0.051
Brugia malayi Myosin head containing protein 0.0006 0.001 0.0031
Echinococcus multilocularis protein dispatched 1 0.005 0.0508 0.0508
Brugia malayi hypothetical protein 0.0246 0.2729 0.8581
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0162 0.0522
Leishmania major cathepsin L-like protease 0.002 0.0162 0.1383
Echinococcus granulosus cathepsin L cysteine protease 0.002 0.0162 0.051
Loa Loa (eye worm) hypothetical protein 0.001 0.0054 0.017
Onchocerca volvulus 0.002 0.0162 0.0558
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0081 0.0223
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0162 0.0522
Loa Loa (eye worm) hypothetical protein 0.0006 0.001 0.0031
Brugia malayi Patched family protein 0.0006 0.001 0.0031
Schistosoma mansoni cpg binding protein 0.0033 0.0316 0.0994
Schistosoma mansoni hypothetical protein 0.0042 0.042 0.132
Loa Loa (eye worm) hypothetical protein 0.0006 0.001 0.0031
Loa Loa (eye worm) hypothetical protein 0.0006 0.001 0.0031
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.002 0.0162 0.1383
Brugia malayi CXXC zinc finger family protein 0.0031 0.0296 0.093
Onchocerca volvulus 0.0012 0.0081 0.026
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0054 0.017
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0219 0.0689
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0054 0.017
Schistosoma mansoni nuclear hormone receptor 0.001 0.0054 0.017
Loa Loa (eye worm) hypothetical protein 0.0012 0.0081 0.0254
Loa Loa (eye worm) hypothetical protein 0.0006 0.001 0.0031
Schistosoma mansoni hypothetical protein 0.005 0.0508 0.1598
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0021 0.0002
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0507 0.1594
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0299 0.0941
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.002 0.0162 0.1383
Trichomonas vaginalis set domain proteins, putative 0.0248 0.2741 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0299 0.0299
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0012 0.0081 0.0223
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0162 0.0447
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0438 0.1377
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.002 0.0162 0.0447
Loa Loa (eye worm) hypothetical protein 0.0012 0.0081 0.0254
Schistosoma mansoni hypothetical protein 0.0041 0.0405 0.1274
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0054 0.017
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0012 0.0081 0.2451
Loa Loa (eye worm) fibroinase 0.002 0.0162 0.051
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0007 0.0021 0.0546
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0021 0.0002
Echinococcus multilocularis cysteine protease 0.002 0.0162 0.0162
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.002 0.0162 0.1383
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0007 0.0021 0.0546
Echinococcus multilocularis survival motor neuron protein 1 0.0246 0.2729 0.2729
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0012 0.0081 0.0254
Loa Loa (eye worm) cysteine protease 0.002 0.0162 0.051
Brugia malayi CHE-14 protein 0.0044 0.0438 0.1377
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0054 0.017
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0286 0.318 1
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0007 0.0021 0.0546
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0054 0.0054
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0097 0.1039 0.3224
Plasmodium falciparum serine repeat antigen 6 0.0012 0.0081 0.4653
Brugia malayi Cathepsin L-like precursor 0.002 0.0162 0.051
Loa Loa (eye worm) hypothetical protein 0.0007 0.0021 0.0066
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0219 0.183
Brugia malayi Pre-SET motif family protein 0.0032 0.0299 0.0941
Entamoeba histolytica cysteine protease, putative 0.002 0.0162 0.1305
Onchocerca volvulus 0.0031 0.0296 0.1047
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0507 0.1594
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0155 0.0487
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0054 0.017
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0507 0.1594
Onchocerca volvulus 0.001 0.0054 0.0162
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0162 0.0522
Entamoeba histolytica cysteine protease, putative 0.0012 0.0081 0.0549
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0299 0.0941
Loa Loa (eye worm) hypothetical protein 0.0006 0.001 0.0031
Loa Loa (eye worm) hypothetical protein 0.0041 0.0405 0.1274
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0054 0.017
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0021 0.0068
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0148 0.9086
Brugia malayi cathepsin Z-like cysteine proteinase 0.0012 0.0081 0.0254
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0007 0.0021 0.0021
Entamoeba histolytica cysteine protease, putative 0.002 0.0162 0.1305
Loa Loa (eye worm) hypothetical protein 0.002 0.0162 0.051
Onchocerca volvulus 0.002 0.0162 0.0558
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0137 0.6071
Echinococcus granulosus FTZ F1 alpha 0.001 0.0054 0.017
Loa Loa (eye worm) hypothetical protein 0.0006 0.001 0.0031
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0054 0.017
Schistosoma mansoni coup transcription factor 0.001 0.0054 0.017
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0162 0.1305
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0162 0.0522
Toxoplasma gondii cathepsin CPC1 0.0012 0.0081 0.0689
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0299 0.0941
Loa Loa (eye worm) hypothetical protein 0.001 0.0054 0.017
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0507 0.0507
Loa Loa (eye worm) hypothetical protein 0.0006 0.001 0.0031
Brugia malayi hypothetical protein 0.0006 0.001 0.0031
Entamoeba histolytica cysteine proteinase 2 0.002 0.0162 0.1305
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0012 0.0081 0.0223
Brugia malayi Patched family protein 0.0006 0.001 0.0031
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0162 0.051
Loa Loa (eye worm) hypothetical protein 0.001 0.0054 0.017
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0162 0.0522
Trypanosoma brucei cysteine peptidase C (CPC) 0.0097 0.1039 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0081 0.0223
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0054 0.0054
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0012 0.0081 0.0223
Onchocerca volvulus 0.0025 0.0219 0.0766
Loa Loa (eye worm) hypothetical protein 0.0006 0.001 0.0031
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0012 0.0081 0.0254
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.002 0.0162 0.1383
Schistosoma mansoni cathepsin C 0.0012 0.0081 0.0254
Plasmodium vivax vivapain-2 0.002 0.0162 0.5267
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0219 1
Echinococcus multilocularis cpg binding protein 0.0033 0.0316 0.0316
Leishmania major cathepsin L-like protease 0.002 0.0162 0.1383
Leishmania major cathepsin L-like protease 0.002 0.0162 0.1383
Loa Loa (eye worm) hypothetical protein 0.0018 0.0148 0.0466
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0405 0.1274
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0162 0.1305
Plasmodium vivax SET domain protein, putative 0.0032 0.0299 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0708 0.2227
Loa Loa (eye worm) hypothetical protein 0.0006 0.001 0.0031
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0508 0.1598
Loa Loa (eye worm) hypothetical protein 0.001 0.0054 0.017
Plasmodium falciparum serine repeat antigen 3 0.0012 0.0081 0.4653
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0021 0.0068
Entamoeba histolytica cysteine protease, putative 0.002 0.0162 0.1305
Brugia malayi cathepsin L-like cysteine proteinase 0.0012 0.0081 0.0254
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0438 0.1377
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0054 0.017
Onchocerca volvulus 0.0007 0.0021 0.0043
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0507 0.0507
Loa Loa (eye worm) hypothetical protein 0.0006 0.001 0.0031
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0162 0.0522
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0007 0.0021 0.0068
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0021 0.0546
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0012 0.0081 0.0223
Entamoeba histolytica cysteine protease, putative 0.002 0.0162 0.1305
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0061 0.0192
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0627 0.5999
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0219 0.1941

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.