Detailed information for compound 156038

Basic information

Technical information
  • TDR Targets ID: 156038
  • Name: 4-(1,8-dihydroxy-9-oxo-10H-anthracene-2-carbo nyl)benzoic acid
  • MW: 374.343 | Formula: C22H14O6
  • H donors: 3 H acceptors: 6 LogP: 4.06 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)c1ccc(cc1)C(=O)c1ccc2c(c1O)C(=O)c1c(C2)cccc1O
  • InChi: 1S/C22H14O6/c23-16-3-1-2-13-10-14-8-9-15(20(25)18(14)21(26)17(13)16)19(24)11-4-6-12(7-5-11)22(27)28/h1-9,23,25H,10H2,(H,27,28)
  • InChiKey: BFGYSIVMWNGAOM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[(1,8-dihydroxy-9-oxo-10H-anthracen-2-yl)-oxomethyl]benzoic acid
  • 4-[(1,8-dihydroxy-9-oxo-10H-anthracen-2-yl)carbonyl]benzoic acid
  • 4-(1,8-dihydroxy-9-keto-10H-anthracene-2-carbonyl)benzoic acid
  • 4-(1,8-dihydroxy-9-oxo10H-anthracene-2-carbonyl)benzoic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bos taurus Arachidonate 5-lipoxygenase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Echinococcus granulosus arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Echinococcus multilocularis arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma japonicum IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma japonicum ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative Get druggable targets OG5_127482 All targets in OG5_127482
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni lipoxygenase 0.01 0.0902 0.0895
Onchocerca volvulus Alhambra homolog 0.0029 0.0109 0.0112
Brugia malayi CXXC zinc finger family protein 0.0032 0.0138 0.0182
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0063 0.0489 0.0654
Mycobacterium tuberculosis Long conserved protein 0.0659 0.7186 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0188 0.1889 0.2587
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0109 0.0343
Echinococcus granulosus snurportin 1 0.0666 0.7259 1
Brugia malayi sterile alpha and TIR motif containing protein 1 isoform a 0.0026 0.0081 0.0102
Onchocerca volvulus 0.0036 0.0184 0.0194
Loa Loa (eye worm) hypothetical protein 0.0024 0.0052 0.005
Schistosoma mansoni loxhd1 0.0024 0.0052 0.0044
Echinococcus multilocularis histone acetyltransferase MYST2 0.01 0.0912 0.1237
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0109 0.0343
Brugia malayi glutathione reductase 0.0046 0.0301 0.0409
Echinococcus granulosus Transglutaminase 0.0659 0.7186 0.9899
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0063 0.0489 0.0654
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0258 0.0774
Mycobacterium ulcerans beta-lactamase 0.0036 0.0184 0.0235
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.1094 0.1504
Loa Loa (eye worm) hypothetical protein 0.0479 0.5161 0.7104
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0142 0.1375 0.1877
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0046 0.0098
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0121 0.1147 0.1562
Loa Loa (eye worm) inositol-1 0.0037 0.02 0.0255
Brugia malayi intermediate filament protein 0.0027 0.0088 0.0112
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.1338 0.1825
Loa Loa (eye worm) hypothetical protein 0.0026 0.0081 0.0091
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0227 0.2335 0.3236
Schistosoma mansoni ap endonuclease 0.0057 0.0426 0.0419
Schistosoma mansoni myst-related protein 0.002 0.0009 0.0001
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.03 0.3151 1
Echinococcus granulosus liprin alpha 2 0.0026 0.0081 0.0091
Entamoeba histolytica hypothetical protein 0.0142 0.1375 1
Entamoeba histolytica hypothetical protein 0.0142 0.1375 1
Schistosoma mansoni chromobox protein 0.0206 0.2102 0.2096
Trypanosoma brucei SAM domain (Sterile alpha motif), putative 0.0026 0.0081 0.021
Echinococcus multilocularis geminin 0.0344 0.3645 0.5011
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0142 0.1383 0.1888
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0088 0.01
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0184 0.0235
Schistosoma mansoni aldehyde dehydrogenase 0.0188 0.1889 0.1883
Brugia malayi Liprin-alpha 2 0.0026 0.0081 0.0102
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0052 0.005
Toxoplasma gondii aldehyde dehydrogenase 0.0188 0.1889 1
Echinococcus multilocularis tumor suppressor p53 binding protein 1 0.0343 0.3633 0.4995
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0525 0.0518
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0184 0.0245
Mycobacterium ulcerans aldehyde dehydrogenase 0.0188 0.1889 0.2613
Echinococcus granulosus importin subunit beta 1 0.0062 0.0485 0.0648
Plasmodium vivax JmjC domain containing protein 0.004 0.0231 0.4224
Schistosoma mansoni lamin 0.0027 0.0088 0.008
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.1338 0.1825
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0184 0.0235
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0188 0.1889 0.5976
Leishmania major hypothetical protein, conserved 0.0036 0.0184 0.0537
Schistosoma mansoni gabp alpha 0.007 0.0576 0.0568
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.02 0.0279
Schistosoma mansoni ran 0.0023 0.0046 0.0038
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0352 0.7205
Loa Loa (eye worm) hypothetical protein 0.0036 0.0184 0.0233
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0525 0.0721
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0525 0.0518
Brugia malayi latrophilin 2 splice variant baaae 0.0136 0.1307 0.181
Echinococcus granulosus polycomb protein SCMH1 0.0278 0.291 0.3996
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0184 0.0176
Schistosoma mansoni cpg binding protein 0.0032 0.0138 0.0131
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0121 0.1147 0.1562
Loa Loa (eye worm) hypothetical protein 0.0024 0.0052 0.005
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0142 0.1383 0.1888
Loa Loa (eye worm) MBCTL1 0.01 0.0912 0.1237
Echinococcus multilocularis lamin dm0 0.0027 0.0088 0.01
Schistosoma mansoni sex comb on midleg homolog 0.0278 0.291 0.2904
Echinococcus multilocularis liprin alpha 2 0.0026 0.0081 0.0091
Entamoeba histolytica hypothetical protein 0.0142 0.1375 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.1338 0.1331
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0157 0.0197
Loa Loa (eye worm) CHromoDomain protein family member 0.003 0.0123 0.0148
Echinococcus multilocularis GPCR, family 2 0.0063 0.0489 0.0654
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0109 0.0102
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0042 0.0256 0.1141
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0135 0.0166
Trichomonas vaginalis ran, putative 0.0023 0.0046 0.0064
Onchocerca volvulus Tankyrase homolog 0.0026 0.0081 0.0081
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0015 0.0008
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0525 0.0704
Echinococcus multilocularis neuropeptide s receptor 0.0457 0.4913 0.6761
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0057 0.0426 1
Echinococcus granulosus sterile alpha and tir motif containing protein 0.0026 0.0081 0.0091
Schistosoma mansoni inositol monophosphatase 0.0037 0.02 0.0193
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0057 0.0426 0.1311
Plasmodium vivax SET domain protein, putative 0.0031 0.0135 0.2033
Mycobacterium tuberculosis Conserved protein 0.0036 0.0184 0.0235
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0138 0.017
Toxoplasma gondii PLU-1 family protein 0.0046 0.0301 0.1384
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.1094 0.1334
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0352 0.1073
Loa Loa (eye worm) hypothetical protein 0.0026 0.0081 0.0091
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.1378 0.4345
Onchocerca volvulus 0.0831 0.9113 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.02 0.0258
Trichomonas vaginalis peptide N-glycanase, putative 0.0659 0.7186 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0081 0.0091
Echinococcus multilocularis polyhomeotic proximal chromatin protein 0.0026 0.0081 0.0091
Loa Loa (eye worm) latrophilin receptor protein 2 0.0063 0.0489 0.0654
Onchocerca volvulus 0.0243 0.2514 0.2752
Giardia lamblia Hypothetical protein 0.0659 0.7186 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0046 0.0043
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.0963 0.1321
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.0963 0.1147
Echinococcus granulosus GA binding protein alpha chain 0.007 0.0576 0.0773
Schistosoma mansoni Protein aveugle 0.0026 0.0081 0.0074
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0258 0.0774
Schistosoma mansoni rab6-interacting 0.0024 0.0052 0.0044
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0109 0.013
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0184 0.0235
Toxoplasma gondii ABC1 family protein 0.0036 0.0184 0.0747
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0135 0.0128
Echinococcus multilocularis polyhomeotic protein 2 0.0026 0.0081 0.0091
Brugia malayi Bromodomain containing protein 0.0029 0.0109 0.0142
Mycobacterium ulcerans hypothetical protein 0.0659 0.7186 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0057 0.0426 0.3056
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0301 0.0911
Schistosoma mansoni jumonji/arid domain-containing protein 0.0134 0.1292 0.1285
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0403 0.431 0.4306
Echinococcus granulosus Sterile alpha motif SAM 0.0026 0.0081 0.0091
Echinococcus granulosus histone acetyltransferase MYST2 0.01 0.0912 0.1237
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0666 0.7259 1
Loa Loa (eye worm) hypothetical protein 0.01 0.0912 0.1237
Schistosoma mansoni myst-related protein 0.002 0.0009 0.0001
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.003 0.0123 0.0148
Echinococcus multilocularis liprin alpha 2 0.0026 0.0081 0.0091
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0352 0.1073
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0057 0.0426 0.0567
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0039 0.0033
Loa Loa (eye worm) hypothetical protein 0.0051 0.0352 0.0464
Mycobacterium ulcerans aldehyde dehydrogenase 0.0188 0.1889 0.2613
Loa Loa (eye worm) hypothetical protein 0.0026 0.0081 0.0091
Mycobacterium ulcerans lipase LipD 0.0036 0.0184 0.0235
Schistosoma mansoni Protein aveugle 0.0026 0.0081 0.0074
Loa Loa (eye worm) doublecortin family protein 0.0024 0.0052 0.005
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0043 0.027 0.1215
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0046 0.0042
Schistosoma mansoni hypothetical protein 0.0023 0.0039 0.0031
Loa Loa (eye worm) mbt repeat family protein 0.029 0.3036 0.4171
Schistosoma mansoni DNA polymerase eta 0.0021 0.0015 0.0008
Echinococcus granulosus jumonji domain containing protein 0.004 0.0236 0.0305
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0184 0.0233
Schistosoma mansoni hypothetical protein 0.0343 0.3633 0.3628
Brugia malayi Inositol-1 0.0037 0.02 0.0268
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.1338 0.1331
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.003 0.0123 0.0148
Brugia malayi AIDA-1b 0.0026 0.0081 0.0102
Toxoplasma gondii hypothetical protein 0.0027 0.0085 0.0214
Brugia malayi hypothetical protein 0.0024 0.0052 0.0062
Schistosoma mansoni phd finger protein 0.0044 0.0284 0.0276
Onchocerca volvulus 0.0043 0.0271 0.0289
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0109 0.1442
Trypanosoma cruzi hypothetical protein 0.0026 0.0081 0.021
Brugia malayi Calcitonin receptor-like protein seb-1 0.0198 0.2012 0.2792
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.0963 0.1321
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0352 0.1073
Brugia malayi Fli-1 protein 0.0214 0.2186 0.3034
Toxoplasma gondii thioredoxin reductase 0.0046 0.0301 0.1383
Brugia malayi Shank2E 0.0026 0.0081 0.0102
Loa Loa (eye worm) fli-1 protein 0.0214 0.2186 0.2997
Schistosoma mansoni hypothetical protein 0.0029 0.0109 0.0102
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0184 0.0256
Mycobacterium leprae Probable lipase LipE 0.0036 0.0184 0.0039
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0455 0.0607
Mycobacterium ulcerans hypothetical protein 0.0659 0.7186 1
Loa Loa (eye worm) tnks protein 0.0026 0.0081 0.0091
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0301 0.0394
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0184 0.0537
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0198 0.2012 0.2756
Mycobacterium tuberculosis Conserved protein 0.0036 0.0184 0.0235
Trypanosoma cruzi Kinesin-13 5, putative 0.0026 0.0081 0.021
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0188 0.1889 0.2613
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0426 0.8774
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0184 0.0537
Schistosoma mansoni hypothetical protein 0.0063 0.0489 0.0482
Brugia malayi cask-interacting protein 2 0.0026 0.0081 0.0102
Echinococcus multilocularis pdz domain containing protein 0.0026 0.0081 0.0091
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0548 0.0541
Brugia malayi RNA, U transporter 1 0.0177 0.1776 0.2463
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 24 0.0026 0.0081 0.021
Trichomonas vaginalis esterase, putative 0.0036 0.0184 0.0256
Brugia malayi Importin beta-1 subunit 0.0062 0.0485 0.0665
Schistosoma mansoni chromodomain helicase DNA binding protein 0.003 0.0123 0.0115
Onchocerca volvulus 0.0024 0.0052 0.0049
Echinococcus granulosus dnaJ subfamily B 0.0449 0.4824 0.6639
Schistosoma mansoni importin beta-1 0.0062 0.0485 0.0477
Echinococcus granulosus geminin 0.0344 0.3645 0.5011
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0138 0.1338 0.1825
Schistosoma mansoni transcription factor LCR-F1 0.0142 0.1375 0.1368
Leishmania major importin beta-1 subunit, putative 0.0051 0.0352 0.1074
Leishmania major trypanothione reductase 0.0046 0.0301 0.0911
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0426 0.0593
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0057 0.0426 0.1311
Onchocerca volvulus 0.0026 0.0081 0.0081
Schistosoma mansoni hypothetical protein 0.0063 0.0489 0.0482
Trichomonas vaginalis set domain proteins, putative 0.0243 0.2514 0.3498
Schistosoma mansoni jumonji/arid domain-containing protein 0.0134 0.1292 0.1285
Toxoplasma gondii exonuclease III APE 0.0057 0.0426 0.2063
Loa Loa (eye worm) hypothetical protein 0.0028 0.0093 0.0108
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0352 0.1658
Schistosoma mansoni polycystin 1-related 0.0024 0.0052 0.0044
Schistosoma mansoni inositol monophosphatase 0.0037 0.02 0.0193
Loa Loa (eye worm) hypothetical protein 0.0027 0.0082 0.0093
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0046 0.0042
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.1378 0.4345
Echinococcus granulosus GPCR family 2 0.0063 0.0489 0.0654
Onchocerca volvulus 0.0027 0.0088 0.0088
Schistosoma mansoni aldehyde dehydrogenase 0.0188 0.1889 0.1883
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.02 0.0279
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.02 0.0836
Plasmodium falciparum JmjC domain-containing protein, putative 0.004 0.0231 0.4676
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.02 0.1401
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0142 0.1378 0.4345
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0057 0.0426 0.0573
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.02 0.0589
Plasmodium falciparum thioredoxin reductase 0.0046 0.0301 0.614
Brugia malayi Pre-SET motif family protein 0.0214 0.2183 0.3031
Brugia malayi CHD4 protein 0.003 0.0123 0.016
Loa Loa (eye worm) hypothetical protein 0.0057 0.0421 0.056
Mycobacterium ulcerans hypothetical protein 0.0036 0.0184 0.0235
Plasmodium falciparum glutathione reductase 0.0046 0.0301 0.614
Echinococcus multilocularis SAM and MBT domain containing protein 0.0403 0.431 0.593
Brugia malayi mbt repeat family protein 0.029 0.3036 0.4219
Schistosoma mansoni lamin 0.0027 0.0088 0.008
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0301 0.0398
Brugia malayi Sphingomyelin synthase-related 1 0.0026 0.0081 0.0102
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0184 0.3141
Schistosoma mansoni intermediate filament proteins 0.0027 0.0088 0.008
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.03 0.3151 1
Echinococcus multilocularis polycomb protein SCMH1 0.0278 0.291 0.3996
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0138 0.1338 0.1853
Echinococcus multilocularis peregrin 0.0029 0.0109 0.013
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.01 0.0912 0.1237
Plasmodium vivax importin-beta 2, putative 0.0062 0.0485 1
Brugia malayi Pre-SET motif family protein 0.0031 0.0135 0.0178
Brugia malayi TAR-binding protein 0.0066 0.0525 0.0721
Loa Loa (eye worm) hypothetical protein 0.0063 0.0489 0.0654
Schistosoma mansoni ap endonuclease 0.0057 0.0426 0.0419
Brugia malayi hypothetical protein 0.0142 0.1375 0.1905
Schistosoma mansoni hypothetical protein 0.0063 0.0489 0.0482
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0046 0.0042
Schistosoma mansoni hypothetical protein 0.0026 0.0081 0.0074
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.0963 0.1321
Echinococcus multilocularis importin subunit beta 1 0.0062 0.0485 0.0648
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0468 0.2287
Loa Loa (eye worm) hypothetical protein 0.0026 0.0081 0.0091
Brugia malayi Doublecortin family protein 0.0024 0.0052 0.0062
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0046 0.0098
Schistosoma mansoni myelin transcription factor 1 myt1 0.01 0.0912 0.0905
Plasmodium vivax multidomain scavenger receptor, putative 0.0024 0.0052 0.0131
Brugia malayi Thioredoxin family protein 0.0659 0.7186 1
Loa Loa (eye worm) hypothetical protein 0.0136 0.1307 0.1783
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.02 0.0589
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.1338 0.1825
Schistosoma mansoni rab6-interacting 0.0024 0.0052 0.0044
Echinococcus multilocularis sterile alpha and tir motif containing protein 0.0026 0.0081 0.0091
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0352 0.6968
Entamoeba histolytica hypothetical protein 0.0051 0.0352 0.2514
Brugia malayi hypothetical protein 0.0024 0.0052 0.0062
Trichomonas vaginalis cgi-62, putative 0.0026 0.0081 0.0113
Schistosoma mansoni lip-related protein (liprin) alpha 0.0026 0.0081 0.0074
Trypanosoma brucei trypanothione reductase 0.0046 0.0301 0.0911
Echinococcus granulosus polyhomeotic protein 2 0.0026 0.0081 0.0091
Onchocerca volvulus 0.0027 0.0088 0.0088
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0052 0.005
Plasmodium falciparum LCCL domain-containing protein 0.0024 0.0052 0.0903
Brugia malayi exodeoxyribonuclease III family protein 0.0057 0.0426 0.0583
Echinococcus multilocularis snurportin 1 0.0666 0.7259 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0109 0.013
Trypanosoma brucei mitochondrial DNA polymerase beta 0.03 0.3151 1
Onchocerca volvulus 0.0026 0.0081 0.0081
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0043 0.0271 0.0263
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0179 0.1795 0.1963
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0135 0.0128
Mycobacterium ulcerans hypothetical protein 0.0158 0.1558 0.2151
Brugia malayi PHD-finger family protein 0.0028 0.0093 0.012
Brugia malayi F/Y-rich N-terminus family protein 0.0036 0.0194 0.026
Schistosoma mansoni hypothetical protein 0.0136 0.1307 0.13
Leishmania major GTP-binding protein, putative 0.0023 0.0046 0.0098
Mycobacterium tuberculosis Conserved hypothetical protein 0.0158 0.1558 0.2151
Schistosoma mansoni ets-related 0.0214 0.2186 0.218
Echinococcus granulosus tar DNA binding protein 0.0066 0.0525 0.0704
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0184 0.0235
Echinococcus multilocularis sphingomyelin synthase protein 1 0.0026 0.0081 0.0091
Entamoeba histolytica hypothetical protein 0.0142 0.1375 1
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0015 0.0011
Plasmodium vivax protein kinase, putative 0.0026 0.0081 0.0799
Loa Loa (eye worm) hypothetical protein 0.0031 0.0135 0.0166
Echinococcus granulosus peregrin 0.0029 0.0109 0.013
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0184 0.0039
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0236 0.0305
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0362 0.1104
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0088 0.0112
Schistosoma mansoni hypothetical protein 0.0142 0.1375 0.1368
Brugia malayi bicaudal-C 0.0026 0.0081 0.0102
Echinococcus granulosus cpg binding protein 0.005 0.0341 0.045
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0063 0.0489 0.0654
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.1094 0.1504
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0184 0.0256
Echinococcus granulosus lamin 0.0027 0.0088 0.01
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.01 0.0912 0.1259
Echinococcus multilocularis Sterile alpha motif SAM 0.0026 0.0081 0.0091
Loa Loa (eye worm) hypothetical protein 0.0179 0.1795 0.2457
Mycobacterium ulcerans aldehyde dehydrogenase 0.0188 0.1889 0.2613
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0046 0.0782
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0258 0.0774
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.0963 0.1321
Echinococcus granulosus pdz domain containing protein 0.0026 0.0081 0.0091
Brugia malayi hypothetical protein 0.0026 0.0081 0.0102
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0184 0.0235
Trichomonas vaginalis importin beta-1, putative 0.0051 0.0352 0.049
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0426 0.0593
Brugia malayi beta-lactamase family protein 0.0036 0.0184 0.0245
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0057 0.0426 0.0573
Brugia malayi hypothetical protein 0.0026 0.0081 0.0102
Echinococcus multilocularis musashi 0.0027 0.0088 0.01
Schistosoma mansoni hypothetical protein 0.0666 0.7259 0.7257
Plasmodium vivax glutathione reductase, putative 0.0046 0.0301 0.5812
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0426 0.867
Onchocerca volvulus 0.0024 0.0052 0.0049
Brugia malayi PHD-finger family protein 0.0029 0.0109 0.0142
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.007 0.0576 0.0773
Loa Loa (eye worm) toll and interleukin 1 receptor domain-containing protein isoform f 0.0026 0.0081 0.0091
Loa Loa (eye worm) beta-lactamase 0.0036 0.0184 0.0233
Brugia malayi mbt repeat family protein 0.0479 0.5161 0.7179
Schistosoma mansoni hypothetical protein 0.0063 0.0489 0.0482
Echinococcus granulosus histone acetyltransferase myst3 0.0044 0.0284 0.0371
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0015 0.0011
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.02 0.0255
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0184 0.0537
Onchocerca volvulus 0.0026 0.0081 0.0081
Mycobacterium tuberculosis Conserved protein 0.0659 0.7186 1
Mycobacterium ulcerans transglutaminase family protein 0.0659 0.7186 1
Echinococcus granulosus Sterile alpha motif type 0.0026 0.0081 0.0091
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0525 0.0518
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0525 0.0518
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0184 0.0256
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0052 0.005
Echinococcus multilocularis lamin 0.0027 0.0088 0.01
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0057 0.0426 0.0567
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0184 0.0233
Schistosoma mansoni cpg binding protein 0.005 0.0341 0.0334
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0184 0.0235
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0046 0.0054
Loa Loa (eye worm) hypothetical protein 0.0026 0.0081 0.0091
Loa Loa (eye worm) hypothetical protein 0.0198 0.2012 0.2756
Schistosoma mansoni sex comb on midleg homolog 0.0278 0.291 0.2904
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.1338 0.1825
Echinococcus multilocularis lysine specific demethylase 5A 0.0116 0.1089 0.1483
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0184 0.0233
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0051 0.0352 0.049
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0184 0.0235
Loa Loa (eye worm) hypothetical protein 0.0062 0.0485 0.0648
Brugia malayi RNA binding protein 0.0066 0.0525 0.0721
Onchocerca volvulus 0.0026 0.0081 0.0081
Toxoplasma gondii hypothetical protein 0.0048 0.0328 0.1527
Echinococcus granulosus neuropeptide s receptor 0.0457 0.4913 0.6761
Brugia malayi jmjC domain containing protein 0.018 0.1809 0.2509
Loa Loa (eye worm) hypothetical protein 0.006 0.0461 0.0615
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.01 0.0912 0.1237
Trichomonas vaginalis c2h2 zinc finger protein, putative 0.0026 0.0081 0.0113
Echinococcus granulosus RUN 0.0024 0.0052 0.005
Brugia malayi beta-lactamase family protein 0.0036 0.0184 0.0245
Plasmodium falciparum importin beta, putative 0.0062 0.0485 1
Echinococcus multilocularis dnaJ subfamily B 0.0449 0.4824 0.6639
Loa Loa (eye worm) jmjC domain-containing protein 0.018 0.1809 0.2476
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0015 0.0021
Onchocerca volvulus 0.0036 0.0184 0.0194
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0109 0.013
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0301 0.0394
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0184 0.0256
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0198 0.2012 0.2792
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0188 0.1889 0.2587
Loa Loa (eye worm) hypothetical protein 0.0036 0.0184 0.0233
Plasmodium falciparum phd finger protein, putative 0.0029 0.0109 0.2111
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0131 0.1252 0.1707
Loa Loa (eye worm) RNA binding protein 0.0066 0.0525 0.0704
Brugia malayi beta-lactamase 0.0036 0.0184 0.0245
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0057 0.0426 0.0573
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0525 0.0704
Trypanosoma brucei importin beta-1 subunit, putative 0.0062 0.0485 0.1497
Giardia lamblia Transglutaminase/protease, putative 0.0659 0.7186 1
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0184 0.0235
Onchocerca volvulus 0.0036 0.0184 0.0194
Loa Loa (eye worm) hypothetical protein 0.0036 0.0184 0.0233
Loa Loa (eye worm) hypothetical protein 0.0036 0.0184 0.0233
Trypanosoma cruzi importin beta-1 subunit, putative 0.0051 0.0352 0.1074
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0214 0.2183 0.2993
Onchocerca volvulus 0.0316 0.3333 0.3652
Loa Loa (eye worm) glutathione reductase 0.0046 0.0301 0.0394
Schistosoma mansoni lipoxygenase 0.0142 0.1383 0.1377
Echinococcus multilocularis chromobox protein 2 0.0206 0.2102 0.2881
Onchocerca volvulus 0.0026 0.0081 0.0081
Echinococcus multilocularis Transglutaminase 0.0659 0.7186 0.9899
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0135 0.0166
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0109 0.013
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0015 0.0021
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0115 0.0137
Mycobacterium tuberculosis Conserved protein 0.0036 0.0184 0.0235
Mycobacterium tuberculosis Probable reductase 0.0105 0.0963 0.1321
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0057 0.0426 0.1311
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0015 0.0008
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0039 0.0033
Brugia malayi N-terminal motif family protein 0.0179 0.1795 0.249
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0301 0.5812
Echinococcus multilocularis RUN 0.0024 0.0052 0.005
Brugia malayi hypothetical protein 0.0033 0.0151 0.0199
Mycobacterium leprae Conserved hypothetical protein 0.0659 0.7186 1
Schistosoma mansoni hypothetical protein 0.0449 0.4824 0.482
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0046 0.0098
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0352 0.7205
Onchocerca volvulus 0.0032 0.0138 0.0144
Loa Loa (eye worm) hypothetical protein 0.0036 0.0184 0.0233
Giardia lamblia Kinesin-13 0.0026 0.0081 0.0092
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0063 0.0489 0.0671
Echinococcus granulosus tumor suppressor p53 binding protein 1 0.0343 0.3633 0.4995
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.0052 0.005
Leishmania major hypothetical protein, conserved 0.0051 0.0352 0.1073
Schistosoma mansoni hypothetical protein 0.0024 0.0052 0.0044
Leishmania major mitochondrial DNA polymerase beta 0.03 0.3151 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.02 0.0279
Mycobacterium tuberculosis Conserved hypothetical protein 0.0659 0.7186 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0015 0.0048
Echinococcus multilocularis cpg binding protein 0.005 0.0341 0.045
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0258 0.0774
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0525 0.0518
Echinococcus multilocularis Sterile alpha motif type 0.0026 0.0081 0.0091
Echinococcus granulosus liprin alpha 2 0.0026 0.0081 0.0091
Schistosoma mansoni cpg binding protein 0.005 0.0341 0.0334
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0135 0.0128
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0184 0.0235
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0558 0.6045 0.8324
Brugia malayi Ets-domain containing protein 0.007 0.0576 0.0791
Giardia lamblia PHD finger protein 15 0.0029 0.0109 0.0131
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0051 0.0352 0.049
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0063 0.0489 0.0654
Mycobacterium tuberculosis Conserved hypothetical protein 0.0659 0.7186 1
Schistosoma mansoni hypothetical protein 0.0659 0.7186 0.7184
Entamoeba histolytica Ran family GTPase 0.0023 0.0046 0.0272
Echinococcus granulosus lysine specific demethylase 5A 0.0134 0.1292 0.1763
Onchocerca volvulus 0.0026 0.0081 0.0081
Schistosoma mansoni hypothetical protein 0.0344 0.3645 0.364
Schistosoma mansoni hypothetical protein 0.0344 0.3645 0.364
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0052 0.005
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.0963 0.1321
Brugia malayi Ets-domain containing protein 0.007 0.0576 0.0791
Toxoplasma gondii HEAT repeat-containing protein 0.0062 0.0485 0.238
Echinococcus granulosus SAM and MBT domain containing protein 0.0403 0.431 0.593
Trypanosoma brucei importin beta-1 subunit, putative 0.0062 0.0485 0.1497
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.02 0.0589
Echinococcus granulosus intermediate filament protein 0.0027 0.0088 0.01
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0525 0.0704
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0088 0.01
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.02 0.0589
Schistosoma mansoni hypothetical protein 0.0026 0.0081 0.0074
Echinococcus granulosus chromobox protein 2 0.0206 0.2102 0.2881
Echinococcus granulosus sphingomyelin synthase protein 1 0.0026 0.0081 0.0091
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0184 0.0256
Schistosoma mansoni lar interacting protein (lip)-related protein 0.0026 0.0081 0.0074
Brugia malayi jmjC domain containing protein 0.0121 0.1147 0.1587
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.1094 0.1504
Echinococcus granulosus polyhomeotic proximal chromatin protein 0.0026 0.0081 0.0091
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0135 0.0166
Schistosoma mansoni polyhomeotic 0.0026 0.0081 0.0074
Brugia malayi Latrophilin receptor protein 2 0.0063 0.0489 0.0671
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0081 0.0113
Loa Loa (eye worm) AIDA-1b 0.0026 0.0081 0.0091
Schistosoma mansoni jumonji domain containing protein 0.0102 0.0928 0.0922
Loa Loa (eye worm) hypothetical protein 0.0026 0.0081 0.0091
Schistosoma mansoni spingomyelin synthetase-related 0.0026 0.0081 0.0074
Loa Loa (eye worm) hypothetical protein 0.0027 0.0088 0.01
Loa Loa (eye worm) hypothetical protein 0.0026 0.0081 0.0091
Brugia malayi hypothetical protein 0.0051 0.0352 0.0479
Echinococcus granulosus lamin dm0 0.0027 0.0088 0.01
Brugia malayi coiled-coil like protein 1 0.0026 0.0081 0.0102
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0184 0.0176
Mycobacterium ulcerans putative transglutaminase-like protein 0.0659 0.7186 1
Echinococcus multilocularis GA binding protein alpha chain 0.007 0.0576 0.0773
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0057 0.0426 0.0567
Brugia malayi Thioredoxin reductase 0.0046 0.0301 0.0409
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0142 0.1375 0.1877
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0479 0.5161 0.5659
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.1338 0.1331
Loa Loa (eye worm) hypothetical protein 0.0036 0.0184 0.0233
Giardia lamblia Giardia trophozoite antigen GTA-1 0.0026 0.0081 0.0092
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.02 0.0255
Trypanosoma cruzi Kinesin-13 5, putative 0.0026 0.0081 0.021
Mycobacterium leprae Conserved hypothetical protein 0.0659 0.7186 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0301 0.0394
Treponema pallidum exodeoxyribonuclease (exoA) 0.0057 0.0426 0.5
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0558 0.6045 0.8324
Echinococcus multilocularis histone acetyltransferase myst3 0.0044 0.0284 0.0371
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.0052 0.005
Mycobacterium tuberculosis Hypothetical protein 0.0659 0.7186 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0131 0.1252 0.1707
Echinococcus granulosus neuropeptide receptor A26 0.0457 0.4913 0.6761
Schistosoma mansoni DNAj-like protein 0.0026 0.0081 0.0074
Echinococcus multilocularis neuropeptide receptor A26 0.0457 0.4913 0.6761
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0057 0.0426 0.1311
Schistosoma mansoni ran 0.0023 0.0046 0.0038

Activities

Activity type Activity value Assay description Source Reference
DD (binding) = 1.34 uM Antioxidant activity, measuring Deoxyribose degradation (DD) as a measure of hydroxyl radical formation. ChEMBL. 9276024
IC50 (functional) = 2 uM 5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leukocytes ChEMBL. 9276024
IC50 (functional) = 2 uM 5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leukocytes ChEMBL. 9276024
IC50 (functional) > 5 uM Antiproliferative activity (AA) against HaCaT keratinocytes. ChEMBL. 9276024
IC50 (functional) > 5 uM Antiproliferative activity (AA) against HaCaT keratinocytes. ChEMBL. 9276024

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 9276024

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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