TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 497.691 | Formula: C33H41N2O2+
H donors: 0 H acceptors: 1 LogP: 6.76 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: O=C([C@](c1ccccc1)(N1CCCCC1)C)O[C@H]1C[N+]2(CCC1CC2)CCc1ccc2c(c1)cccc2
InChi: 1S/C33H41N2O2/c1-33(30-12-4-2-5-13-30,34-19-8-3-9-20-34)32(36)37-31-25-35(22-17-28(31)18-23-35)21-16-26-14-15-27-10-6-7-11-29(27)24-26/h2,4-7,10-15,24,28,31H,3,8-9,16-23,25H2,1H3/q+1/t28?,31-,33-,35?/m0/s1
InChiKey: VLWKCPPUBKYCEF-BQTUONFDSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cholinergic receptor, muscarinic 3	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_133264	All targets in OG5_133264
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_133264	All targets in OG5_133264

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0167	0.0846	1
Trypanosoma brucei	low molecular weight protein tyrosine phosphatase, putative	0.0101	0.0446	0.1433
Trichomonas vaginalis	set domain proteins, putative	0.0233	0.1252	0.5801
Echinococcus granulosus	roundabout 2	0.009	0.0379	0.0469
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0167	0.0846	0.1047
Onchocerca volvulus		0.0167	0.0846	0.0935
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0167	0.0846	0.1039
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0186	0.0961	0.1182
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0167	0.0846	0.1039
Brugia malayi	hypothetical protein	0.0167	0.0846	0.084
Schistosoma mansoni	factor for adipocyte differentiation	0.009	0.0379	0.0461
Echinococcus multilocularis	titin	0.009	0.0379	0.0461
Onchocerca volvulus	4.1 G protein, putative homolog	0.0167	0.0846	0.0935
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0167	0.0846	0.084
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.1352	0.808	0.8551
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0846	0.0889
Echinococcus multilocularis	roundabout 2	0.009	0.0379	0.0461
Onchocerca volvulus		0.0233	0.1252	0.1387
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0257	0.1398	0.173
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 30.	0.009	0.0379	0.0373
Schistosoma mansoni	protein tyrosine phosphatase	0.0167	0.0846	0.1039
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0846	0.0889
Echinococcus granulosus	titin	0.009	0.0379	0.0469
Schistosoma mansoni	nephrin	0.009	0.0379	0.0461
Schistosoma mansoni	factor for adipocyte differentiation	0.009	0.0379	0.0461
Echinococcus granulosus	cell adhesion molecule	0.009	0.0379	0.0469
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0329	0.1835	1
Echinococcus granulosus	Netrin receptor DCC	0.009	0.0379	0.0469
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.009	0.0379	0.0469
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0167	0.0846	0.1047
Loa Loa (eye worm)	hypothetical protein	0.0186	0.0961	0.101
Giardia lamblia	Low molecular weight protein-tyrosine-phosphatase	0.0329	0.1835	1
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0846	0.0889
Schistosoma mansoni	cell adhesion molecule	0.009	0.0379	0.0461
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0167	0.0846	1
Brugia malayi	hypothetical protein	0.009	0.0379	0.0373
Echinococcus multilocularis	Fibronectin, type III	0.009	0.0379	0.0461
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0167	0.0846	0.0889
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0167	0.0846	0.1047
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.009	0.0379	0.0395
Echinococcus multilocularis	Netrin receptor DCC	0.009	0.0379	0.0461
Brugia malayi	Low molecular weight phosphotyrosine protein phosphatase containing protein	0.0329	0.1835	0.1829
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.1352	0.808	1
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0167	0.0846	0.1039
Onchocerca volvulus		0.0167	0.0846	0.0935
Onchocerca volvulus		0.0167	0.0846	0.0935
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0329	0.1835	1
Echinococcus granulosus	neuroglian	0.009	0.0379	0.0469
Echinococcus granulosus	roundabout 2	0.009	0.0379	0.0469
Loa Loa (eye worm)	myotactin form A	0.009	0.0379	0.0395
Echinococcus multilocularis	usherin	0.009	0.0379	0.0461
Loa Loa (eye worm)	hypothetical protein	0.009	0.0379	0.0395
Echinococcus granulosus	anosmin 1	0.009	0.0379	0.0469
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0257	0.1398	0.1723
Brugia malayi	Lethal protein 805	0.009	0.0379	0.0373
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.009	0.0379	0.0395
Loa Loa (eye worm)	hypothetical protein	0.1409	0.8429	0.8921
Leishmania major	hypothetical protein, conserved	0.0101	0.0446	0.1433
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0167	0.0846	0.084
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0257	0.1398	0.1723
Echinococcus granulosus	Fibronectin type III domain containing protein	0.009	0.0379	0.0469
Brugia malayi	Fibronectin type III domain containing protein	0.009	0.0379	0.0373
Schistosoma mansoni	serine/threonine protein kinase	0.009	0.0379	0.0461
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.009	0.0379	0.0395
Echinococcus multilocularis	fibronectin type III domain-containing protein	0.009	0.0379	0.0461
Onchocerca volvulus		0.0329	0.1835	0.2037
Loa Loa (eye worm)	hypothetical protein	0.0186	0.0961	0.101
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0624	0.3638	0.4503
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0257	0.1398	0.173
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0846	0.0889
Loa Loa (eye worm)	hypothetical protein	0.009	0.0379	0.0395
Onchocerca volvulus		0.0167	0.0846	0.0935
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0846	0.0889
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0167	0.0846	0.1047
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0167	0.0846	0.1047
Echinococcus granulosus	Down syndrome cell adhesion molecule	0.009	0.0379	0.0469
Onchocerca volvulus		0.1499	0.8981	1
Echinococcus granulosus	contactin	0.009	0.0379	0.0469
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0846	0.0889
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0167	0.0846	0.0889
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0167	0.0846	0.0889
Brugia malayi	hypothetical protein	0.0167	0.0846	0.084
Brugia malayi	hypothetical protein	0.0167	0.0846	0.084
Brugia malayi	Immunoglobulin I-set domain containing protein	0.009	0.0379	0.0373
Loa Loa (eye worm)	hypothetical protein	0.009	0.0379	0.0395
Schistosoma mansoni	neuroglian	0.009	0.0379	0.0461
Onchocerca volvulus		0.0167	0.0846	0.0935
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0167	0.0846	0.0889
Schistosoma mansoni	tripartite motif protein trim9	0.009	0.0379	0.0461
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0167	0.0846	0.0889
Loa Loa (eye worm)	hypothetical protein	0.009	0.0379	0.0395
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0167	0.0846	0.1039
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0167	0.0846	0.084
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0624	0.3638	0.4499
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0846	0.0889
Loa Loa (eye worm)	hypothetical protein	0.009	0.0379	0.0395
Onchocerca volvulus		0.0167	0.0846	0.0935
Brugia malayi	Immunoglobulin I-set domain containing protein	0.009	0.0379	0.0373
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1352	0.808	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0167	0.0846	0.0889
Schistosoma mansoni	factor for adipocyte differentiation	0.009	0.0379	0.0461
Loa Loa (eye worm)	hypothetical protein	0.009	0.0379	0.0395
Loa Loa (eye worm)	phosphotyrosine protein phosphatase	0.0329	0.1835	0.1936
Onchocerca volvulus		0.0167	0.0846	0.0935
Onchocerca volvulus		0.0167	0.0846	0.0935
Echinococcus multilocularis	Down syndrome cell adhesion molecule	0.009	0.0379	0.0461
Loa Loa (eye worm)	hypothetical protein	0.009	0.0379	0.0395
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.009	0.0379	0.0395
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0167	0.0846	0.1047
Echinococcus granulosus	Fibronectin type III	0.009	0.0379	0.0469
Loa Loa (eye worm)	hypothetical protein	0.009	0.0379	0.0395
Trypanosoma cruzi	hypothetical protein, conserved	0.0101	0.0446	0.1433
Brugia malayi	Immunoglobulin I-set domain containing protein	0.009	0.0379	0.0373
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0329	0.1835	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0101	0.0446	0.1433
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0846	0.0889
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0329	0.1835	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0167	0.0846	0.1039
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0167	0.0846	0.0889
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0329	0.1835	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.009	0.0379	0.0373
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.009	0.0379	0.0395
Schistosoma mansoni	hypothetical protein	0.009	0.0379	0.0461
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0167	0.0846	0.1039
Onchocerca volvulus		0.009	0.0379	0.0415
Brugia malayi	hypothetical protein	0.0167	0.0846	0.084
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0167	0.0846	0.084
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0715	0.4191	0.5187
Echinococcus multilocularis	hypothetical protein	0.0167	0.0846	0.1039
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0167	0.0846	0.0889
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0167	0.0846	0.1039
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0167	0.0846	0.1039
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0846	0.0889
Brugia malayi	hypothetical protein	0.009	0.0379	0.0373
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0167	0.0846	0.0889
Onchocerca volvulus		0.009	0.0379	0.0415
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0846	0.0889
Brugia malayi	Immunoglobulin I-set domain containing protein	0.009	0.0379	0.0373
Onchocerca volvulus		0.0167	0.0846	0.0935
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.009	0.0379	0.0395
Loa Loa (eye worm)	projectin	0.009	0.0379	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0846	0.0889
Loa Loa (eye worm)	hypothetical protein	0.009	0.0379	0.0395
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0007	0.0008
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0257	0.1398	0.1723
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0167	0.0846	0.1039
Onchocerca volvulus		0.0167	0.0846	0.0935
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0167	0.0846	0.084
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0329	0.1835	1
Brugia malayi	Fibronectin type III domain containing protein	0.009	0.0379	0.0373
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.009	0.0379	0.0469
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0846	0.0889
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0167	0.0846	0.0889
Onchocerca volvulus		0.0186	0.0961	0.1063
Loa Loa (eye worm)	hypothetical protein	0.0503	0.2897	0.3062
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.1352	0.808	0.8078
Echinococcus multilocularis	Fibronectin type III domain containing protein	0.009	0.0379	0.0461
Brugia malayi	Lethal protein 805	0.009	0.0379	0.0373
Onchocerca volvulus		0.009	0.0379	0.0415
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1352	0.808	1
Brugia malayi	protein unc-22	0.009	0.0379	0.0373
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0167	0.0846	0.0889
Brugia malayi	Protein-tyrosine phosphatase	0.0167	0.0846	0.084
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0167	0.0846	0.1039
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0167	0.0846	0.084
Echinococcus granulosus	titin	0.009	0.0379	0.0469
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0167	0.0846	0.1047
Onchocerca volvulus		0.009	0.0379	0.0415
Plasmodium vivax	SET domain protein, putative	0.0029	0.0007	0.5
Onchocerca volvulus		0.0167	0.0846	0.0935
Echinococcus granulosus	G1Y162 protein	0.009	0.0379	0.0469
Onchocerca volvulus		0.009	0.0379	0.0415
Schistosoma mansoni	protein tyrosine phosphatase	0.0257	0.1398	0.1723
Onchocerca volvulus		0.009	0.0379	0.0415
Echinococcus granulosus	anosmin 1	0.009	0.0379	0.0469
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0167	0.0846	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0167	0.0846	0.1047
Echinococcus multilocularis		0.0167	0.0846	0.1039
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0167	0.0846	0.1039
Loa Loa (eye worm)	lethal protein 805	0.009	0.0379	0.0395
Loa Loa (eye worm)	hypothetical protein	0.009	0.0379	0.0395
Onchocerca volvulus		0.009	0.0379	0.0415
Onchocerca volvulus		0.009	0.0379	0.0415
Echinococcus granulosus	nephrin	0.009	0.0379	0.0469
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0167	0.0846	0.0889
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0329	0.1835	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.009	0.0379	0.0373
Echinococcus granulosus	usherin	0.009	0.0379	0.0469
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0167	0.0846	0.1039
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0257	0.1398	0.1723
Schistosoma mansoni	cell adhesion molecule	0.009	0.0379	0.0461
Brugia malayi	myotactin form A	0.009	0.0379	0.0373
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0167	0.0846	0.1039
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0846	0.0889
Schistosoma mansoni	hypothetical protein	0.009	0.0379	0.0461
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0167	0.0846	0.1047
Loa Loa (eye worm)	hypothetical protein	0.1576	0.9448	1
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.009	0.0379	0.0395
Onchocerca volvulus		0.009	0.0379	0.0415
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.009	0.0379	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0846	0.0889
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0167	0.0846	0.084
Brugia malayi	Immunoglobulin I-set domain containing protein	0.009	0.0379	0.0373
Echinococcus multilocularis	roundabout 2	0.009	0.0379	0.0461
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	0.0227	0.1216	0.5
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0167	0.0846	0.0889
Schistosoma mansoni	myosin-binding protein-related	0.009	0.0379	0.0461
Loa Loa (eye worm)	hypothetical protein	0.009	0.0379	0.0395
Brugia malayi	Fibronectin type III domain containing protein	0.009	0.0379	0.0373
Brugia malayi	Fibronectin type III domain containing protein	0.009	0.0379	0.0373
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0799	0.4704	0.5819
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0846	0.0889
Onchocerca volvulus		0.0167	0.0846	0.0935
Onchocerca volvulus		0.0167	0.0846	0.0935
Trichomonas vaginalis	pten, drome, putative	0.0167	0.0846	0.2877
Onchocerca volvulus		0.0167	0.0846	0.0935
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.009	0.0379	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0846	0.0889
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0167	0.0846	1
Loa Loa (eye worm)	hypothetical protein	0.009	0.0379	0.0395
Echinococcus multilocularis	anosmin 1	0.009	0.0379	0.0461
Brugia malayi	Fibronectin type III domain containing protein	0.009	0.0379	0.0373
Onchocerca volvulus		0.0167	0.0846	0.0935
Echinococcus multilocularis	Netrin receptor DCC	0.009	0.0379	0.0461
Loa Loa (eye worm)	hypothetical protein	0.009	0.0379	0.0395
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.009	0.0379	0.0461
Echinococcus granulosus	anosmin 1	0.009	0.0379	0.0469
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0167	0.0846	0.084
Brugia malayi	Immunoglobulin I-set domain containing protein	0.009	0.0379	0.0373
Schistosoma mansoni	hemicentin	0.009	0.0379	0.0461
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0257	0.1398	0.1473
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0257	0.1398	0.1723
Schistosoma mansoni	nephrin	0.009	0.0379	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0846	0.0889
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0167	0.0846	0.084
Onchocerca volvulus		0.0167	0.0846	0.0935
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 32	0.009	0.0379	0.0373
Loa Loa (eye worm)	hypothetical protein	0.009	0.0379	0.0395
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0007	0.5
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0167	0.0846	0.1047
Onchocerca volvulus		0.0167	0.0846	0.0935
Onchocerca volvulus		0.009	0.0379	0.0415
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0257	0.1398	0.173
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0257	0.1398	0.1723
Onchocerca volvulus		0.0167	0.0846	0.0935
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0167	0.0846	0.084
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0167	0.0846	0.1039
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.009	0.0379	0.0461
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0167	0.0846	0.1039
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0846	0.0889
Echinococcus granulosus	fibronectin type III domain-containing protein	0.009	0.0379	0.0469
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0167	0.0846	0.084
Brugia malayi	hypothetical protein	0.0167	0.0846	0.084
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0167	0.0846	0.1039
Echinococcus multilocularis	titin	0.009	0.0379	0.0461
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0167	0.0846	0.1047
Onchocerca volvulus		0.0167	0.0846	0.0935
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0167	0.0846	0.084
Loa Loa (eye worm)	hypothetical protein	0.1409	0.8429	0.8921
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0846	0.0889
Onchocerca volvulus		0.009	0.0379	0.0415
Brugia malayi	Trypsin family protein	0.0186	0.0961	0.0955
Schistosoma mansoni	cell adhesion molecule	0.009	0.0379	0.0461
Loa Loa (eye worm)	hypothetical protein	0.009	0.0379	0.0395
Loa Loa (eye worm)	hypothetical protein	0.1409	0.8429	0.8921
Loa Loa (eye worm)	hypothetical protein	0.009	0.0379	0.0395
Echinococcus granulosus	roundabout 2	0.009	0.0379	0.0469
Brugia malayi	Pre-SET motif family protein	0.0205	0.1079	0.1073
Brugia malayi	Immunoglobulin I-set domain containing protein	0.009	0.0379	0.0373
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0186	0.0961	0.1182
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.009	0.0379	0.0373
Onchocerca volvulus		0.0167	0.0846	0.0935
Schistosoma mansoni	titin	0.009	0.0379	0.0461
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0257	0.1398	0.1723
Echinococcus granulosus	Netrin receptor DCC	0.009	0.0379	0.0469
Schistosoma mansoni	titin	0.009	0.0379	0.0461
Loa Loa (eye worm)	hypothetical protein	0.009	0.0379	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0503	0.2897	0.3062
Loa Loa (eye worm)	CAMK protein kinase	0.009	0.0379	0.0395
Echinococcus multilocularis	cell adhesion molecule	0.009	0.0379	0.0461
Echinococcus multilocularis	roundabout 2	0.009	0.0379	0.0461
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0257	0.1398	0.1723
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0846	0.0889
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0167	0.0846	0.084
Onchocerca volvulus		0.0167	0.0846	0.0935
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0167	0.0846	0.0889
Brugia malayi	SPRY domain containing protein	0.009	0.0379	0.0373
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.009	0.0379	0.0395
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0167	0.0846	0.0889
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0846	0.0889
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0167	0.0846	0.084
Onchocerca volvulus		0.0167	0.0846	0.0935
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0846	0.0889
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0167	0.0846	0.084
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0167	0.0846	0.084
Onchocerca volvulus		0.009	0.0379	0.0415
Echinococcus multilocularis	neuroglian	0.009	0.0379	0.0461
Brugia malayi	Immunoglobulin I-set domain containing protein	0.009	0.0379	0.0373
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0846	0.0889
Loa Loa (eye worm)	hypothetical protein	0.009	0.0379	0.0395
Schistosoma mansoni	cell adhesion molecule	0.009	0.0379	0.0461
Brugia malayi	Immunoglobulin I-set domain containing protein	0.009	0.0379	0.0373
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0846	0.0889
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0167	0.0846	0.084
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0846	0.0889
Schistosoma mansoni	pcd6 interacting protein-related	0.0167	0.0846	0.1039
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0167	0.0846	0.1039
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0205	0.1079	0.1136
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0167	0.0846	0.1039
Echinococcus multilocularis	transfer RNA-Phe	0.009	0.0379	0.0461
Brugia malayi	Fibronectin type III domain containing protein	0.009	0.0379	0.0373
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0257	0.1398	0.1723
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0167	0.0846	0.084
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0167	0.0846	0.0889
Loa Loa (eye worm)	hypothetical protein	0.009	0.0379	0.0395
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0167	0.0846	0.1039
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0257	0.1398	0.1723
Schistosoma mansoni	protein tyrosine phosphatase	0.0167	0.0846	0.1039
Echinococcus multilocularis	Phosphotidylinositol phosphatase PTPRQ	0.009	0.0379	0.0461
Schistosoma mansoni	ephrin receptor	0.009	0.0379	0.0461
Schistosoma mansoni	hypothetical protein	0.009	0.0379	0.0461
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0167	0.0846	0.084
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0167	0.0846	0.1039
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0167	0.0846	0.084
Schistosoma mansoni	titin	0.009	0.0379	0.0461
Schistosoma mansoni	cell adhesion molecule	0.009	0.0379	0.0461
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0167	0.0846	0.084
Loa Loa (eye worm)	hypothetical protein	0.009	0.0379	0.0395
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0167	0.0846	0.1039
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0167	0.0846	0.1039
Echinococcus multilocularis	anosmin 1	0.009	0.0379	0.0461
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0167	0.0846	0.1039
Onchocerca volvulus		0.009	0.0379	0.0415
Brugia malayi	Protein-tyrosine phosphatase 1	0.0167	0.0846	0.084
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0167	0.0846	0.1047
Echinococcus multilocularis	anosmin 1	0.009	0.0379	0.0461
Onchocerca volvulus		0.0174	0.0887	0.0981
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0167	0.0846	0.0889
Echinococcus granulosus	EG95	0.009	0.0379	0.0469
Onchocerca volvulus		0.0167	0.0846	0.0935
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0167	0.0846	0.0889
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpA	0.0329	0.1835	0.5
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0167	0.0846	0.1047
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0167	0.0846	0.084
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0329	0.1835	1
Brugia malayi	myotactin form B	0.009	0.0379	0.0373
Brugia malayi	Immunoglobulin I-set domain containing protein	0.009	0.0379	0.0373
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0167	0.0846	0.084
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.009	0.0379	0.0469
Leishmania major	tyrosine specific protein phosphatase, putative	0.0167	0.0846	1
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0257	0.1398	0.1723
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0167	0.0846	0.084
Loa Loa (eye worm)	UNCoordinated family member	0.009	0.0379	0.0395
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0167	0.0846	1
Loa Loa (eye worm)	hypothetical protein	0.009	0.0379	0.0395

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 9.7	Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL.	22047691
PPB (ADMET)	= 99.7 %	Plasma protein binding in human	ChEMBL.	22047691

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1921910

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1563148