Detailed information for compound 1563832

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 339.224 | Formula: C16H19BrO3
  • H donors: 0 H acceptors: 1 LogP: 4.21 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: BrCc1c(OCC(C)C)ccc2c1oc(CC)cc2=O
  • InChi: 1S/C16H19BrO3/c1-4-11-7-14(18)12-5-6-15(19-9-10(2)3)13(8-17)16(12)20-11/h5-7,10H,4,8-9H2,1-3H3
  • InChiKey: PTHGIULXTPKAPQ-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major glucose transporter, lmgt3 0.0034 0.0606 0.0703
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0698 0.0698
Echinococcus granulosus General substrate transporter 0.0093 0.1916 0.2225
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0398 0.0462
Echinococcus multilocularis General substrate transporter 0.0093 0.1916 0.2225
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0034 0.0606 0.0704
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0398 0.0462
Toxoplasma gondii ABC1 family protein 0.0038 0.0698 0.0811
Trypanosoma cruzi metacaspase 5, putative 0.0017 0.0244 0.0303
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0205 0.0238
Plasmodium vivax calcium-dependent protein kinase, putative 0.0034 0.0606 0.0606
Plasmodium falciparum proline--tRNA ligase 0.0038 0.07 0.07
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0606 0.0704
Echinococcus granulosus apoptotic protease activating factor 1 0.004 0.0746 0.0866
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0234
Entamoeba histolytica adenosine deaminase, putative 0.0399 0.8612 1
Brugia malayi hypothetical protein 0.0015 0.0201 0.0234
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0606 0.0703
Leishmania major AMP deaminase, putative,amp deaminase-like protein 0.0373 0.8043 0.9339
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0201 0.0234
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0034 0.0606 0.0704
Onchocerca volvulus 0.0027 0.0464 0.0312
Plasmodium falciparum calcium-dependent protein kinase 5 0.0034 0.0606 0.0606
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0234
Mycobacterium ulcerans integral membrane transport protein 0.0015 0.0201 0.0234
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0234
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1212 0.1407
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0034 0.0606 0.0704
Trichomonas vaginalis glucose transporter, putative 0.0034 0.0606 0.0703
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0234
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0882 0.1024
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0234
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0012 0.0119 0.0138
Schistosoma mansoni adenosine deaminase 0.0399 0.8612 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.0244 0.0283
Echinococcus granulosus solute carrier family 22 0.0015 0.0201 0.0234
Brugia malayi Smad1 0.0009 0.0054 0.0062
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0882 0.1024
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0033 0.0581 0.0675
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0525 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0464 0.0538
Schistosoma mansoni smad1 5 8 and 0.0009 0.0054 0.0062
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0606 0.0753
Plasmodium vivax proline--tRNA ligase, putative 0.0038 0.07 0.07
Brugia malayi hypothetical protein 0.0037 0.0673 0.0782
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0698 0.0811
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0525 0.0525
Onchocerca volvulus 0.0038 0.0698 0.0591
Schistosoma mansoni Smad4 0.0009 0.0054 0.0062
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0034 0.0606 0.0704
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1212 0.1407
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0525 0.0609
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.001 0.0012
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0999 0.116
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.2625 0.3048
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0021 0.0318 0.0369
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0999 0.116
Echinococcus granulosus adenosine deaminase 0.0399 0.8612 1
Entamoeba histolytica hypothetical protein 0.0037 0.0673 0.0782
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0999 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.001 0.0012
Trypanosoma cruzi AMP deaminase, putative 0.0373 0.8043 1
Schistosoma mansoni caspase-3 (C14 family) 0.0017 0.0244 0.0283
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0234
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.001 0.0012
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0234
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0525 0.0525
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.0244 0.0283
Brugia malayi MH2 domain containing protein 0.0009 0.0054 0.0062
Brugia malayi intermediate filament protein 0.0027 0.0464 0.0538
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0034 0.0606 0.0606
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.0399 0.8612 1
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.2305 0.2677
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0283 0.0328
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.006 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.001 0.0012
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0525 0.0609
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0606 0.0704
Trypanosoma cruzi hexose transporter 0.0034 0.0606 0.0753
Entamoeba histolytica hypothetical protein 0.0024 0.0398 0.0462
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0234
Brugia malayi MH2 domain containing protein 0.0126 0.2625 0.3048
Brugia malayi MH1 domain containing protein 0.0009 0.0054 0.0062
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0283 0.0328
Trypanosoma brucei glucose transporter, putative 0.0034 0.0606 0.0753
Brugia malayi Sugar transporter family protein 0.0015 0.0201 0.0234
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0024 0.0398 0.0495
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0242 0.5183 0.6018
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.2625 0.3048
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0109 0.2251 0.2614
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0024 0.0028
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.2305 0.2677
Loa Loa (eye worm) sugar transporter 0.0109 0.2251 0.2614
Schistosoma mansoni AMP deaminase 0.0373 0.8043 0.9339
Trichomonas vaginalis CAMK family protein kinase 0.0034 0.0606 0.0704
Loa Loa (eye worm) AMP deaminase 0.0373 0.8043 0.9339
Loa Loa (eye worm) beta-lactamase 0.0038 0.0698 0.0811
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0234
Echinococcus granulosus lamin 0.0027 0.0464 0.0538
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0234
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0698 0.0811
Plasmodium falciparum calcium-dependent protein kinase 2 0.0034 0.0606 0.0606
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0606 0.0704
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0464 0.0538
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0033 0.0581 0.0675
Brugia malayi major facilitator superfamily protein 0.0015 0.0201 0.0234
Loa Loa (eye worm) phosphofructokinase 0.0111 0.2305 0.2677
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0234
Loa Loa (eye worm) hypothetical protein 0.0057 0.1123 0.1304
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0283 0.0352
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0234
Brugia malayi hypothetical protein 0.0015 0.0201 0.0234
Leishmania major adenine aminohydrolase 0.0399 0.8612 1
Brugia malayi adenosine monophosphate deaminase 0.0373 0.8043 0.9339
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0109 0.2251 0.2614
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0244 0.0283
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0201 0.0234
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0054 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0606 0.0703
Loa Loa (eye worm) hypothetical protein 0.0024 0.0398 0.0462
Trypanosoma cruzi metacaspase, putative 0.0017 0.0244 0.0303
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.07 0.0813
Onchocerca volvulus Cell death protein 3 homolog 0.0057 0.1123 0.1096
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0999 0.116
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0698 0.0811
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0698 0.0811
Trypanosoma brucei glucose transporter, putative 0.0034 0.0606 0.0753
Schistosoma mansoni sugar transporter 0.0015 0.0201 0.0234
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0109 0.2251 0.2614
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0882 0.1024
Brugia malayi CXXC zinc finger family protein 0.0029 0.0503 0.0584
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0999 0.116
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0606 0.0753
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0283 0.0352
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0201 0.0234
Trypanosoma brucei glucose transporter, putative 0.0034 0.0606 0.0753
Trypanosoma brucei protein kinase, putative 0.0052 0.0999 0.1243
Plasmodium falciparum calcium-dependent protein kinase 4 0.0034 0.0606 0.0606
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0234
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0698 0.0811
Trypanosoma cruzi metacaspase 5, putative 0.0017 0.0244 0.0303
Mycobacterium ulcerans lipase LipD 0.0038 0.0698 0.0811
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0063 0.0073
Plasmodium vivax CDK-related protein kinase 6, putative 0.0462 1 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0234
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0525 0.0609
Plasmodium vivax adenosine deaminase, putative 0.0399 0.8612 0.8612
Schistosoma mansoni protein kinase 0.0034 0.0606 0.0704
Echinococcus granulosus Smad4 0.0009 0.0054 0.0062
Loa Loa (eye worm) hypothetical protein 0.0038 0.0698 0.0811
Trypanosoma brucei AMP deaminase, putative 0.0373 0.8043 1
Echinococcus multilocularis solute carrier family 22 0.0015 0.0201 0.0234
Onchocerca volvulus 0.0029 0.0503 0.0358
Brugia malayi MH1 domain containing protein 0.0009 0.0054 0.0062
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.1072 0.1245
Echinococcus multilocularis solute carrier family 22 0.0015 0.0201 0.0234
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0999 0.116
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0234
Entamoeba histolytica adenosine deaminase, putative 0.0399 0.8612 1
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0201 0.0234
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0234
Echinococcus multilocularis cpg binding protein 0.0031 0.0539 0.0626
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0999 0.1243
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0673 0.0782
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0999 0.1243
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0205 0.0238
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0938 0.1089
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0698 0.0811
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0525 0.0609
Brugia malayi hypothetical protein 0.004 0.0746 0.0866
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0234
Leishmania major myo-inositol/proton symporter (MIT) 0.0015 0.0201 0.0234
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.0244 0.0283
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0398 0.0462
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0234
Mycobacterium ulcerans beta-lactamase 0.0038 0.0698 0.0811
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0017 0.0244 0.0283
Trichomonas vaginalis esterase, putative 0.0038 0.0698 0.0811
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0606 0.0703
Schistosoma mansoni ap endonuclease 0.0019 0.0283 0.0328
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0999 0.116
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0234
Giardia lamblia Lysyl-tRNA synthetase 0.0024 0.0398 0.3985
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.0244 0.0283
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0234
Loa Loa (eye worm) hypothetical protein 0.0013 0.0154 0.0179
Chlamydia trachomatis lysine--tRNA ligase 0.0024 0.0398 0.7588
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0503 0.0584
Brugia malayi lysyl-tRNA synthetase 0.0024 0.0398 0.0462
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0234
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0111 0.2305 0.2866
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0244 0.0283
Schistosoma mansoni adenosine deaminase-related 0.0399 0.8612 1
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0111 0.2305 0.2677
Trypanosoma brucei glucose transporter, putative 0.0034 0.0606 0.0753
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0606 0.0753
Echinococcus granulosus caspase 2 0.0057 0.1123 0.1304
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0205 0.0238
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.001 0.0012
Onchocerca volvulus AMP deaminase 2 homolog 0.0373 0.8043 0.9323
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1212 0.1407
Echinococcus multilocularis musashi 0.0027 0.0464 0.0538
Trypanosoma brucei adenosine monophosphate deaminase, putative 0.0373 0.8043 1
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0525 0.0609
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0698 0.0811
Trichomonas vaginalis myo-inositol transporter, putative 0.0015 0.0201 0.0234
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0054 0.0062
Trypanosoma brucei metacaspase 0.0017 0.0244 0.0303
Loa Loa (eye worm) hypothetical protein 0.0027 0.0453 0.0526
Plasmodium vivax metacaspase 1, putative 0.0017 0.0244 0.0244
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0882 0.1024
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0024 0.0028
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0525 0.0609
Schistosoma mansoni cpg binding protein 0.0029 0.0503 0.0584
Trichomonas vaginalis glucose transporter, putative 0.0015 0.0201 0.0234
Echinococcus multilocularis GPCR, family 2 0.0015 0.0205 0.0238
Echinococcus multilocularis solute carrier family 22 0.0015 0.0201 0.0234
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0054 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.001 0.0012
Trypanosoma cruzi adenosine monophosphate deaminase-like protein, putative 0.0373 0.8043 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.0244 0.0283
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0606 0.0753
Plasmodium falciparum calcium-dependent protein kinase 1 0.0034 0.0606 0.0606
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0033 0.0581 0.0675
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0017 0.0244 0.0283
Loa Loa (eye worm) hypothetical protein 0.0038 0.0698 0.0811
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0606 0.0703
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0205 0.0238
Plasmodium falciparum lysine--tRNA ligase 0.0024 0.0398 0.0398
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.1212 0.1407
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.001 0.0012
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0234
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0606 0.0703
Leishmania major glucose transporter/membrane transporter D2, putative 0.0034 0.0606 0.0703
Plasmodium falciparum AMP deaminase, putative 0.0373 0.8043 0.8043
Schistosoma mansoni protein kinase 0.0034 0.0606 0.0704
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0283 1
Toxoplasma gondii sugar transporter ST1 0.0015 0.0201 0.0234
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0024 0.0028
Brugia malayi major facilitator superfamily protein 0.0015 0.0201 0.0234
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0234
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.0398 0.0462
Toxoplasma gondii facilitative glucose transporter GT1 0.0109 0.2251 0.2614
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0234
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0234
Trypanosoma cruzi metacaspase, putative 0.0017 0.0244 0.0303
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0244 0.0283
Schistosoma mansoni hypothetical protein 0.0033 0.0599 0.0695
Echinococcus multilocularis lamin 0.0027 0.0464 0.0538
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0024 0.0398 0.0495
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0154 0.0179
Loa Loa (eye worm) Smad1 0.0009 0.0054 0.0062
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0033 0.0581 0.0675
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0015 0.0201 0.025
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0234
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0525 0.0609
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.016 0.0185
Trypanosoma brucei glucose transporter 2A 0.0034 0.0606 0.0753
Echinococcus granulosus lamin dm0 0.0027 0.0464 0.0538
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0201 0.0234
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0034 0.0606 0.0704
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0154 0.0179
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0283 0.0283
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0525 0.0609
Loa Loa (eye worm) hypothetical protein 0.0013 0.0143 0.0167
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0606 0.0704
Schistosoma mansoni hypothetical protein 0.0015 0.0205 0.0238
Plasmodium vivax sugar transporter, putative 0.0015 0.0201 0.0201
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0698 0.0811
Entamoeba histolytica hypothetical protein 0.0037 0.0673 0.0782
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0201 0.0234
Echinococcus granulosus intermediate filament protein 0.0027 0.0464 0.0538
Echinococcus multilocularis Smad4 0.0009 0.0054 0.0062
Schistosoma mansoni cpg binding protein 0.0031 0.0539 0.0626
Echinococcus multilocularis adenosine deaminase 0.0399 0.8612 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0234
Schistosoma mansoni sugar transporter 0.0015 0.0201 0.0234
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0054 0.0062
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0882 0.1024
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0698 0.0811
Treponema pallidum prolyl-tRNA synthetase 0.0012 0.0119 0.0138
Trichomonas vaginalis helicase, putative 0.0007 0.001 0.0012
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0698 0.0811
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0244 0.0283
Trichomonas vaginalis adenosine deaminase, putative 0.0399 0.8612 1
Trypanosoma brucei metacaspase 5, putative 0.0017 0.0244 0.0303
Echinococcus multilocularis AMP deaminase 2 0.0373 0.8043 0.9339
Schistosoma mansoni glucose transport protein 0.0109 0.2251 0.2614
Trypanosoma brucei AMP deaminase, putative 0.0373 0.8043 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0234
Giardia lamblia Prolyl-tRNA synthetase 0.0033 0.0581 0.5818
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0109 0.2251 0.2614
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0283 0.0328
Echinococcus granulosus caspase 8 0.0017 0.0244 0.0283
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0024 0.0028
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0464 0.0538
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.001 0.0012
Entamoeba histolytica hypothetical protein 0.0037 0.0673 0.0782
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0698 0.0811
Loa Loa (eye worm) hypothetical protein 0.0034 0.0606 0.0704
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0999 0.1243
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.001 0.0012
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0234
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0234
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.1216 0.1412
Brugia malayi Cam kinase protein 1 0.0034 0.0606 0.0704
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0244 0.0283
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0234
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0054 0.0062
Chlamydia trachomatis proline--tRNA ligase 0.0012 0.0119 0.2259
Schistosoma mansoni intermediate filament proteins 0.0027 0.0464 0.0538
Echinococcus multilocularis apoptotic protease activating factor 1 0.004 0.0746 0.0866
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0109 0.2251 0.2614
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0034 0.0606 0.0754
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0525 0.0525
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0234
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0234
Leishmania major adenosine monophosphate deaminase, putative,AMP deaminase, putative 0.0373 0.8043 0.9339
Giardia lamblia Sugar-proton symporter 0.0015 0.0201 0.2013
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0698 0.0811
Loa Loa (eye worm) hypothetical protein 0.0015 0.0205 0.0238
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0882 0.1024
Brugia malayi Cell death protein 3 precursor 0.0057 0.1123 0.1304
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.2305 0.2677
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0673 0.0782
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0525 0.0609
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.001 0.0012
Loa Loa (eye worm) hypothetical protein 0.0033 0.0581 0.0675
Trichomonas vaginalis glucose transporter, putative 0.0034 0.0606 0.0703
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0015 0.0201 0.0234
Schistosoma mansoni ap endonuclease 0.0019 0.0283 0.0328
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0999 0.116
Brugia malayi hypothetical protein 0.0015 0.0201 0.0234
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0063 0.0073
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.2305 0.2677
Trypanosoma cruzi sugar transporter, putative 0.0015 0.0201 0.025
Plasmodium falciparum protein kinase 7 0.0308 0.6615 0.6615
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0109 0.2251 0.2614
Onchocerca volvulus Adenosine deaminase homolog 0.0399 0.8612 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0038 0.07 0.087
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.2305 0.2677
Leishmania major AMP deaminase, putative,adenosine monophosphate deaminase-like protein 0.0373 0.8043 0.9339
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0034 0.0606 0.0606
Mycobacterium tuberculosis Probable adenosine deaminase Add (adenosine aminohydrolase) 0.0399 0.8612 1
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0017 0.0244 0.0283
Trypanosoma cruzi glucose transporter, putative 0.0015 0.0201 0.025
Loa Loa (eye worm) hypothetical protein 0.0017 0.0244 0.0283
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.2305 0.2677
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0698 0.0868
Trichomonas vaginalis conserved hypothetical protein 0.0109 0.2251 0.2614
Plasmodium falciparum calcium-dependent protein kinase 3 0.0034 0.0606 0.0606
Plasmodium falciparum mitogen-activated protein kinase 2 0.0176 0.373 0.373
Echinococcus multilocularis caspase 8 0.0017 0.0244 0.0283
Toxoplasma gondii protein kinase, putative 0.0308 0.6615 0.7681
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0234
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0698 0.0811
Plasmodium falciparum hexose transporter 0.0109 0.2251 0.2251
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0234
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0882 0.1024
Plasmodium falciparum adenosine deaminase 0.0399 0.8612 0.8612
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0015 0.0201 0.7115
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.0333 0.0386
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0999 0.116
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0176 0.373 0.4331
Mycobacterium ulcerans hypothetical protein 0.0038 0.0698 0.0811
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0033 0.0581 0.0675
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0999 0.1243
Schistosoma mansoni glucose transport protein 0.0109 0.2251 0.2614
Schistosoma mansoni protein kinase 0.0034 0.0606 0.0704
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0234
Loa Loa (eye worm) hypothetical protein 0.0196 0.4164 0.4835
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0234
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.0399 0.8612 1
Echinococcus granulosus GPCR family 2 0.0015 0.0205 0.0238
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0201 0.0234
Echinococcus multilocularis lysyl tRNA synthetase 0.0024 0.0398 0.0462
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0606 0.0704
Entamoeba histolytica hypothetical protein 0.0037 0.0673 0.0782
Schistosoma mansoni smad1 5 8 and 0.0009 0.0054 0.0062
Trypanosoma brucei glucose transporter, putative 0.0034 0.0606 0.0753
Echinococcus granulosus solute carrier family 22 0.0015 0.0201 0.0234
Plasmodium vivax adenosine/AMP deaminase, putative 0.0373 0.8043 0.8043
Loa Loa (eye worm) hypothetical protein 0.0177 0.3745 0.4348
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0938 0.1089
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.001 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0201 0.0234
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0698 0.0811
Echinococcus multilocularis smad 0.0009 0.0054 0.0062
Trichomonas vaginalis sugar transport protein, putative 0.0015 0.0201 0.0234
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0234
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0234
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0698 0.0811
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0109 0.2251 0.2614
Loa Loa (eye worm) hypothetical protein 0.0027 0.0464 0.0538
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0525 0.0609
Schistosoma mansoni hypothetical protein 0.0015 0.0205 0.0238
Onchocerca volvulus 0.0196 0.4164 0.4712
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0015 0.0201 0.0234
Schistosoma mansoni hypothetical protein 0.0109 0.2251 0.2614
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0017 0.0244 0.0283
Echinococcus granulosus caspase 0.0017 0.0244 0.0283
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0999 0.116
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0033 0.0581 0.0675
Treponema pallidum adenosine deaminase 0.0399 0.8612 1
Leishmania major hypothetical protein, conserved 0.0038 0.0698 0.0811
Schistosoma mansoni hypothetical protein 0.0037 0.0673 0.0782
Plasmodium falciparum metacaspase-like protein 0.0017 0.0244 0.0244
Onchocerca volvulus 0.0038 0.0698 0.0591
Brugia malayi 6-phosphofructokinase 0.0111 0.2305 0.2677
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.2305 0.2677
Schistosoma mansoni hypothetical protein 0.004 0.0746 0.0866
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0201 0.0234
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0234
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0698 0.0811
Leishmania major protein kinase, putative 0.0034 0.0606 0.0704
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.2305 0.2677
Entamoeba histolytica AMP deaminase, putative 0.0373 0.8043 0.9339
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0234
Schistosoma mansoni smad 0.0009 0.0054 0.0062
Loa Loa (eye worm) hypothetical protein 0.0203 0.4314 0.5009
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0038 0.07 0.0813
Brugia malayi Sugar transporter family protein 0.0109 0.2251 0.2614
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0234
Trypanosoma cruzi adenosine monophosphate deaminase, putative 0.0373 0.8043 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0698 0.0811
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0033 0.0581 0.0675
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0234
Trypanosoma brucei glucose transporter, putative 0.0034 0.0606 0.0753
Entamoeba histolytica protein kinase, putative 0.0034 0.0606 0.0704
Schistosoma mansoni lamin 0.0027 0.0464 0.0538
Plasmodium vivax hexose transporter 0.0109 0.2251 0.2251
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0673 0.0782
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.2305 0.2677
Trypanosoma brucei Metacaspase-4 0.0017 0.0244 0.0303
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.1212 0.1407
Schistosoma mansoni sugar transporter 0.0015 0.0201 0.0234
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0606 0.0753
Brugia malayi beta-lactamase family protein 0.0038 0.0698 0.0811
Leishmania major lysyl-tRNA synthetase, putative 0.0024 0.0398 0.0462
Trypanosoma cruzi hexose transporter, putative 0.0015 0.0201 0.025
Loa Loa (eye worm) hypothetical protein 0.0203 0.4314 0.5009
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0205 0.0238
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0205 0.0238
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.2305 0.2677
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.07 0.0813
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0283 0.0328
Entamoeba histolytica AMP deaminase, putative 0.0373 0.8043 0.9339
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.1212 0.1407
Loa Loa (eye worm) hypothetical protein 0.0038 0.0698 0.0811
Leishmania major hypothetical protein, conserved 0.0015 0.0201 0.0234
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0234
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0034 0.0606 0.0606
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0205 0.0238
Schistosoma mansoni smad1 5 8 and 0.0009 0.0054 0.0062
Loa Loa (eye worm) hypothetical protein 0.0026 0.0447 0.0519
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0525 0.0609
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0201 0.0234
Mycobacterium tuberculosis Conserved protein 0.0038 0.0698 0.0811
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.0244 0.0283
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0015 0.0201 0.0201
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0999 0.116
Brugia malayi MAP kinase sur-1 0.0052 0.0999 0.116
Trypanosoma brucei glucose transporter, putative 0.0034 0.0606 0.0753
Echinococcus multilocularis caspase 0.0017 0.0244 0.0283
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0201 0.0234
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0034 0.0606 0.0704
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0201 0.0234
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0283 0.0283
Onchocerca volvulus 0.004 0.0746 0.0647
Toxoplasma gondii transporter, major facilitator family protein 0.0015 0.0201 0.0234
Mycobacterium tuberculosis Conserved protein 0.0038 0.0698 0.0811
Brugia malayi 6-phosphofructokinase 0.0111 0.2305 0.2677
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0054 0.0062
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0111 0.2305 0.2677
Loa Loa (eye worm) hypothetical protein 0.0013 0.0143 0.0167
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.001 0.0012
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0054 0.0062
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0283 0.0328
Mycobacterium ulcerans 6-phosphofructokinase 0.0111 0.2305 0.2677
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0017 0.0244 0.0283
Leishmania major hypothetical protein, conserved 0.0196 0.4164 0.4835
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0201 0.0234
Schistosoma mansoni hypothetical protein 0.0015 0.0205 0.0238
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0283 0.0328
Schistosoma mansoni cpg binding protein 0.0031 0.0539 0.0626
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0698 0.0868
Leishmania major metacaspase, putative 0.0017 0.0244 0.0283
Toxoplasma gondii sugar transporter ST3 0.0015 0.0201 0.0234
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0999 0.116
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0698 0.0811
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0063 0.0073
Trypanosoma cruzi metacaspase, putative 0.0017 0.0244 0.0303
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0017 0.0244 0.0283
Echinococcus granulosus solute carrier family 22 0.0015 0.0201 0.0234
Toxoplasma gondii exonuclease III APE 0.0019 0.0283 0.0328
Schistosoma mansoni sugar transporter 0.0015 0.0201 0.0234
Onchocerca volvulus 0.0038 0.0698 0.0591
Echinococcus multilocularis lamin dm0 0.0027 0.0464 0.0538
Loa Loa (eye worm) hypothetical protein 0.0399 0.8612 1
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1212 0.1407
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0111 0.2305 0.2677
Trypanosoma brucei glucose transporter, putative 0.0034 0.0606 0.0753
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.1212 0.1407
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0186 0.0216
Mycobacterium tuberculosis Conserved protein 0.0038 0.0698 0.0811
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0021 0.0318 0.0369
Echinococcus granulosus smad 0.0009 0.0054 0.0062
Loa Loa (eye worm) hypothetical protein 0.0049 0.0938 0.1089
Brugia malayi phosphofructokinase 0.0111 0.2305 0.2677
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0234
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.0244 0.0283
Loa Loa (eye worm) hypothetical protein 0.0038 0.0698 0.0811
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0283 0.0352
Plasmodium vivax lysine--tRNA ligase, putative 0.0024 0.0398 0.0398
Trypanosoma cruzi AMP deaminase, putative 0.0373 0.8043 1
Echinococcus granulosus solute carrier family 22 0.0015 0.0201 0.0234
Loa Loa (eye worm) hypothetical protein 0.0203 0.4314 0.5009
Toxoplasma gondii lysine-tRNA ligase 0.0024 0.0398 0.0462
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0283 0.0328
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0033 0.0581 0.0675
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0283 0.0328
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0938 0.1089
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0034 0.0606 0.0704
Schistosoma mansoni lamin 0.0027 0.0464 0.0538
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.0244 0.0283
Trichomonas vaginalis adenosine deaminase, putative 0.0399 0.8612 1
Echinococcus granulosus lysyl tRNA synthetase 0.0024 0.0398 0.0462
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0234
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0525 0.0525
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0024 0.0028
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0283 0.2829
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0109 0.2251 0.2614
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0525 1
Giardia lamblia Hexose transporter 0.0015 0.0201 0.2013
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0606 0.0704
Echinococcus multilocularis solute carrier family 22 0.0015 0.0201 0.0234
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0283 0.0328
Schistosoma mansoni hypothetical protein 0.0015 0.0205 0.0238
Loa Loa (eye worm) hypothetical protein 0.0038 0.0698 0.0811
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.001 0.0012
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0015 0.0201 0.0234
Trypanosoma brucei metacaspase MCA3 0.0017 0.0244 0.0303
Plasmodium vivax hypothetical protein, conserved 0.0017 0.0244 0.0244
Echinococcus multilocularis 6 phosphofructokinase 0.0111 0.2305 0.2677
Brugia malayi beta-lactamase family protein 0.0038 0.0698 0.0811
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0021 0.0318 0.0369
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0599 0.0695
Schistosoma mansoni glucose transport protein 0.0109 0.2251 0.2614
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0525 0.5251
Echinococcus granulosus AMP deaminase 2 0.0373 0.8043 0.9339
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0999 0.1243
Loa Loa (eye worm) hypothetical protein 0.0033 0.0581 0.0675
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0234
Leishmania major glucose transporter, lmgt2 0.0034 0.0606 0.0703
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0234
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.07 0.087
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0698 0.0811
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0999 0.116
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0882 0.1024
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0283 0.0328
Loa Loa (eye worm) sugar transporter 0.0015 0.0201 0.0234
Mycobacterium leprae Probable lipase LipE 0.0038 0.0698 0.0811
Leishmania major AMP deaminase, putative 0.0373 0.8043 0.9339
Echinococcus multilocularis caspase 2 0.0057 0.1123 0.1304
Toxoplasma gondii AMP deaminase 0.0373 0.8043 0.9339
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0283 0.0328
Schistosoma mansoni caspase-7 (C14 family) 0.0017 0.0244 0.0283
Entamoeba histolytica protein kinase, putative 0.0034 0.0606 0.0704
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0017 0.0244 0.0283
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0111 0.2305 0.2866
Trypanosoma cruzi AMP deaminase, putative 0.0373 0.8043 1
Echinococcus granulosus 6 phosphofructokinase 0.0111 0.2305 0.2677
Loa Loa (eye worm) hypothetical protein 0.0033 0.0599 0.0695
Trypanosoma cruzi AMP deaminase 2, putative 0.0196 0.4164 0.5177
Mycobacterium ulcerans sugar transporter 0.0015 0.0201 0.0234
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.001 0.0012
Trypanosoma cruzi hexose transporter, putative 0.0018 0.027 0.0336
Brugia malayi MH2 domain containing protein 0.0009 0.0054 0.0062
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0038 0.07 0.087
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1212 0.1407
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.001 0.0012
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0698 0.0811
Loa Loa (eye worm) hypothetical protein 0.0203 0.4314 0.5009
Leishmania major glucose transporter, lmgt1 0.0034 0.0606 0.0703
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0398 0.0462
Onchocerca volvulus 0.0027 0.0464 0.0312
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0015 0.0201 0.0234
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0398 0.0462
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0201 0.0234
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.001 0.0012
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0234
Trypanosoma brucei metacaspase MCA2 0.0017 0.0244 0.0303
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0999 0.116
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0606 0.0704
Echinococcus multilocularis calcium dependent protein kinase 0.0031 0.0551 0.064
Mycobacterium leprae Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) 0.0399 0.8612 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0186 0.0216
Trypanosoma brucei sugar transporter, putative 0.0015 0.0201 0.025
Trypanosoma brucei AMP deaminase, putative 0.0373 0.8043 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0606 0.0753
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0698 0.0811
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.1212 0.1407
Brugia malayi Adenosine/AMP deaminase family protein 0.0399 0.8612 1
Echinococcus granulosus calcium dependent protein kinase 0.0031 0.0551 0.064
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.0244 0.0283
Mycobacterium ulcerans adenosine deaminase 0.0399 0.8612 1
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0698 0.0868
Schistosoma mansoni caspase-7 (C14 family) 0.0057 0.1123 0.1304
Trypanosoma cruzi AMP deaminase, putative 0.0373 0.8043 1
Brugia malayi beta-lactamase 0.0038 0.0698 0.0811
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0244 0.0283
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.001 0.0012
Plasmodium falciparum metacaspase 1 0.0017 0.0244 0.0244
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.2305 0.2677
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0606 0.0704
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0882 0.1024
Trypanosoma cruzi metacaspase, putative 0.0017 0.0244 0.0303
Schistosoma mansoni glucose transporter 0.0015 0.0201 0.0234
Loa Loa (eye worm) hypothetical protein 0.004 0.0746 0.0866
Trypanosoma brucei glucose transporter 1E 0.0034 0.0606 0.0753
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0234
Trypanosoma cruzi AMP deaminase, putative 0.0373 0.8043 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0033 0.0581 0.0675
Toxoplasma gondii sugar transporter ST2 0.0015 0.0201 0.0234
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0698 0.0811
Brugia malayi Sugar transporter family protein 0.0015 0.0201 0.0234
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0176 0.373 0.373
Leishmania major ATP-dependent phosphofructokinase 0.0111 0.2305 0.2677
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0525 0.0609
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0201 0.0234
Echinococcus granulosus cpg binding protein 0.0031 0.0539 0.0626

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) > 29.48 uM Antiproliferative activity against human KB cells after 72 hrs by SRB assay ChEMBL. 22265685
GI50 (functional) > 29.48 uM Antiproliferative activity against human A549 cells after 72 hrs by SRB assay ChEMBL. 22265685
GI50 (functional) > 29.48 uM Antiproliferative activity against human DU145 cells after 72 hrs by SRB assay ChEMBL. 22265685

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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