Detailed information for compound 1571949

Basic information

Technical information
  • TDR Targets ID: 1571949
  • Name: 2-[4-(4-chlorophenyl)piperazin-1-yl]-6-methyl -1H-pyrimidin-4-one
  • MW: 304.775 | Formula: C15H17ClN4O
  • H donors: 1 H acceptors: 3 LogP: 3.26 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)N1CCN(CC1)c1nc(C)cc(n1)O
  • InChi: 1S/C15H17ClN4O/c1-11-10-14(21)18-15(17-11)20-8-6-19(7-9-20)13-4-2-12(16)3-5-13/h2-5,10H,6-9H2,1H3,(H,17,18,21)
  • InChiKey: UXKJDTLACPLWET-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[4-(4-chlorophenyl)-1-piperazinyl]-6-methyl-1H-pyrimidin-4-one
  • STK249475
  • 2-[4-(4-chlorophenyl)-1-piperazinyl]-6-methyl-4(3H)-pyrimidinone
  • MLS001163082
  • SMR000499391
  • ZINC04818128

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glutaminase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0254 0.1553
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0035 0.0181 0.017
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0012 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0035 0.0181 0.0181
Trypanosoma cruzi DNA polymerase kappa, putative 0.0013 0.0025 0.0088
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0181 0.0181
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0013 0.0025 0.0013
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0035 0.0181 0.0181
Echinococcus multilocularis dna polymerase kappa 0.0013 0.0025 0.0013
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0013 0.0025 0.0543
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0035 0.0181 0.017
Trichomonas vaginalis alpha-glucosidase, putative 0.0025 0.0112 0.0424
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0035 0.0181 0.017
Onchocerca volvulus 0.0035 0.0181 0.114
Leishmania major cathepsin L-like protease 0.0044 0.0254 1
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0215 0.1517 0.1507
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0254 0.1553
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0035 0.0181 0.017
Loa Loa (eye worm) hypothetical protein 0.0164 0.1141 0.1141
Trypanosoma cruzi DNA polymerase kappa, putative 0.0013 0.0025 0.0088
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0181 0.0181
Onchocerca volvulus 0.0035 0.0181 0.114
Echinococcus multilocularis musashi 0.0019 0.0064 0.0053
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0035 0.0181 0.017
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0181 0.0181
Brugia malayi hypothetical protein 0.0035 0.0181 0.0181
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0022 0.0087 0.7584
Onchocerca volvulus 0.0066 0.041 0.268
Mycobacterium tuberculosis Conserved hypothetical protein 0.0013 0.0025 0.5
Onchocerca volvulus 0.0035 0.0181 0.114
Schistosoma mansoni ankyrin 23/unc44 0.0016 0.0045 0.0034
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.0035 0.0181 0.0181
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0041 0.0225 0.1436
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0035 0.0181 0.7006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0254 0.1553
Trypanosoma cruzi cruzipain precursor, putative 0.0044 0.0254 0.1627
Schistosoma mansoni intermediate filament proteins 0.0019 0.0064 0.0053
Brugia malayi Cathepsin L-like precursor 0.0012 0.0012 0.0012
Echinococcus granulosus Ankyrin 0.0016 0.0045 0.0034
Onchocerca volvulus 0.0035 0.0181 0.114
Onchocerca volvulus 0.0019 0.0064 0.0354
Schistosoma mansoni microtubule-associated protein tau 0.048 0.3471 0.3464
Onchocerca volvulus 0.0035 0.0181 0.114
Loa Loa (eye worm) fibroinase 0.0012 0.0012 0.0012
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0025 0.0112 0.5887
Echinococcus granulosus dna polymerase kappa 0.0013 0.0025 0.0013
Loa Loa (eye worm) hypothetical protein 0.0035 0.0181 0.0181
Trypanosoma cruzi cysteine peptidase, putative 0.0044 0.0254 0.1627
Loa Loa (eye worm) hypothetical protein 0.0213 0.1497 0.1497
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.0045 0.0034
Onchocerca volvulus 0.0035 0.0181 0.114
Schistosoma mansoni alpha-glucosidase 0.0098 0.0646 0.0635
Echinococcus multilocularis 0.0035 0.0181 0.017
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0035 0.0181 0.017
Brugia malayi Cathepsin L-like precursor 0.0012 0.0012 0.0012
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0035 0.0181 0.017
Trichomonas vaginalis DNA polymerase eta, putative 0.0013 0.0025 0.0056
Schistosoma mansoni hypothetical protein 0.0016 0.0045 0.0034
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0213 0.1497 0.1487
Brugia malayi hypothetical protein 0.0035 0.0181 0.0181
Trichomonas vaginalis alpha-glucosidase, putative 0.0025 0.0112 0.0424
Brugia malayi Cathepsin L-like precursor 0.0012 0.0012 0.0012
Onchocerca volvulus 0.0035 0.0181 0.114
Brugia malayi Uncoordinated protein 44 0.0016 0.0045 0.0045
Trypanosoma cruzi cysteine peptidase, putative 0.0044 0.0254 0.1627
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0254 0.1553
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0035 0.0181 0.017
Leishmania major DNA polymerase eta, putative 0.0022 0.0087 0.3128
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0719 0.524 0.5234
Brugia malayi Papain family cysteine protease containing protein 0.0012 0.0012 0.0012
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0035 0.0181 0.017
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0035 0.0181 0.017
Trichomonas vaginalis glutaminase, putative 0.033 0.2364 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0181 0.0181
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0213 0.1497 1
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0035 0.0181 0.017
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0181 0.0181
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0035 0.0181 0.0181
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0035 0.0181 0.017
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0181 0.0181
Trypanosoma cruzi major cysteine proteinase, putative 0.0035 0.0183 0.1155
Brugia malayi Protein kinase domain containing protein 0.0215 0.1517 0.1517
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0035 0.0181 0.017
Schistosoma mansoni lamin 0.0019 0.0064 0.0053
Loa Loa (eye worm) MH2 domain-containing protein 0.0083 0.0539 0.0539
Brugia malayi hypothetical protein 0.0164 0.1141 0.1141
Brugia malayi probable protein kinase 0.0722 0.5259 0.5259
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0181 0.0181
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0025 0.0112 0.5887
Echinococcus multilocularis Ankyrin 0.0016 0.0045 0.0034
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0035 0.0181 0.017
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0035 0.0181 0.017
Loa Loa (eye worm) hypothetical protein 0.0035 0.0181 0.0181
Echinococcus multilocularis geminin 0.0118 0.0796 0.0786
Echinococcus multilocularis lysosomal alpha glucosidase 0.0113 0.0763 0.0752
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0113 0.0763 0.0763
Echinococcus multilocularis lysosomal alpha glucosidase 0.0113 0.0763 0.0752
Brugia malayi Protein-tyrosine phosphatase 0.0035 0.0181 0.0181
Loa Loa (eye worm) glutaminase 2 0.033 0.2364 0.2364
Onchocerca volvulus 0.0035 0.0181 0.114
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0035 0.0181 0.0181
Brugia malayi hypothetical protein 0.0213 0.1497 0.1497
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0156 0.0969
Echinococcus granulosus geminin 0.0118 0.0796 0.0786
Trichomonas vaginalis alpha-glucosidase, putative 0.0025 0.0112 0.0424
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0035 0.0181 0.017
Schistosoma mansoni hypothetical protein 0.0213 0.1497 0.1487
Mycobacterium ulcerans glutaminase 0.033 0.2364 1
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0035 0.0181 0.017
Brugia malayi hypothetical protein 0.0105 0.0702 0.0702
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0025 0.0112 1
Schistosoma mansoni rap gtpase-activating protein 0.0213 0.1497 0.1487
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0035 0.0181 0.017
Brugia malayi Intermediate filament tail domain containing protein 0.0019 0.0064 0.0064
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0035 0.0181 0.0181
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0215 0.1517 0.1507
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0035 0.0181 0.017
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0045 0.0045
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0035 0.0181 0.0181
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0035 0.0181 0.017
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0035 0.0181 0.017
Echinococcus multilocularis neutral alpha glucosidase AB 0.0025 0.0112 0.01
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0035 0.0181 0.0181
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0181 0.0181
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0012 0.0012 0.5
Schistosoma mansoni protein kinase 0.0215 0.1517 0.1507
Schistosoma mansoni survival motor neuron protein 0.0034 0.0174 0.0162
Brugia malayi Glycosyl hydrolases family 31 protein 0.0113 0.0763 0.0763
Loa Loa (eye worm) protein-tyrosine phosphatase 0.1364 1 1
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.1364 1 1
Loa Loa (eye worm) hypothetical protein 0.0719 0.524 0.524
Echinococcus granulosus protein tyrosine phosphatase n9 0.0035 0.0181 0.017
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0019 0.0064 0.0064
Brugia malayi ImpB/MucB/SamB family protein 0.0031 0.0156 0.0156
Loa Loa (eye worm) cysteine protease 0.0012 0.0012 0.0012
Brugia malayi hypothetical protein 0.0035 0.0181 0.0181
Entamoeba histolytica deoxycytidyl transferase, putative 0.0013 0.0025 0.0775
Trypanosoma brucei protein tyrosine phosphatase 1 0.0035 0.0181 0.1061
Loa Loa (eye worm) hypothetical protein 0.0035 0.0181 0.0181
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0564 0.4092 0.4085
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0035 0.0181 0.017
Onchocerca volvulus 0.0035 0.0181 0.114
Trichomonas vaginalis sucrase-isomaltase, putative 0.0025 0.0112 0.0424
Echinococcus granulosus neutral alpha glucosidase AB 0.0025 0.0112 0.01
Echinococcus multilocularis microtubule associated protein 2 0.048 0.3471 0.3464
Loa Loa (eye worm) hypothetical protein 0.0035 0.0181 0.0181
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0254 0.1553
Schistosoma mansoni vam6/vps39 related 0.0213 0.1497 0.1487
Schistosoma mansoni protein kinase 0.0722 0.5259 0.5254
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0213 0.1497 0.1487
Schistosoma mansoni netrin receptor unc5 0.0016 0.0045 0.0034
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0035 0.0181 0.017
Schistosoma mansoni serine/threonine protein kinase 0.0215 0.1517 0.1507
Plasmodium vivax vivapain-2 0.0012 0.0012 0.5
Onchocerca volvulus 4.1 G protein, putative homolog 0.0035 0.0181 0.114
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0.0045 0.0034
Loa Loa (eye worm) hypothetical protein 0.0213 0.1497 0.1497
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0215 0.1517 0.1507
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0241 0.1707 0.1697
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.1364 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0012
Onchocerca volvulus 0.0035 0.0181 0.114
Leishmania major cathepsin L-like protease 0.0044 0.0254 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0254 0.1553
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0035 0.0181 0.017
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0215 0.1517 0.1507
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0013 0.0025 0.0013
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0181 0.0181
Echinococcus multilocularis lamin dm0 0.0019 0.0064 0.0053
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0035 0.0181 0.017
Loa Loa (eye worm) hypothetical protein 0.0035 0.0181 0.0181
Schistosoma mansoni lamin 0.0019 0.0064 0.0053
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0035 0.0181 0.017
Brugia malayi ImpB/MucB/SamB family protein 0.0013 0.0025 0.0025
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0181 0.0181
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0035 0.0181 0.017
Brugia malayi hypothetical protein 0.0035 0.0181 0.0181
Leishmania major tyrosine specific protein phosphatase, putative 0.0035 0.0181 0.7006
Leishmania major DNA polymerase eta, putative 0.0031 0.0156 0.5957
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0112 0.0671
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0035 0.0181 0.114
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0181 0.0181
Echinococcus multilocularis lamin 0.0019 0.0064 0.0053
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0025 0.0112 0.0112
Brugia malayi Glycosyl hydrolases family 31 protein 0.0025 0.0112 0.0112
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0035 0.0181 0.0181
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0035 0.0181 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0035 0.0181 0.017
Schistosoma mansoni DNA polymerase eta 0.0031 0.0156 0.0144
Echinococcus multilocularis netrin receptor unc 5 0.0016 0.0045 0.0034
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0012 0.0012 0.5
Loa Loa (eye worm) hypothetical protein 0.0035 0.0181 0.0181
Leishmania major DNA polymerase kappa, putative 0.0013 0.0025 0.0543
Trypanosoma brucei glucosidase, putative 0.0025 0.0112 0.0588
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0035 0.0181 0.0181
Echinococcus granulosus protein kinase 0.0509 0.3688 0.368
Loa Loa (eye worm) hypothetical protein 0.0035 0.0181 0.0181
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0035 0.0181 0.017
Brugia malayi Temporarily assigned gene name protein 59 0.0213 0.1497 0.1497
Loa Loa (eye worm) hypothetical protein 0.0035 0.0181 0.0181
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0035 0.0181 0.017
Loa Loa (eye worm) hypothetical protein 0.0035 0.0181 0.0181
Onchocerca volvulus 0.0035 0.0181 0.114
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0035 0.0181 0.114
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0035 0.0181 0.017
Echinococcus multilocularis 0.0509 0.3688 0.368
Onchocerca volvulus 0.0035 0.0181 0.114
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0035 0.0181 0.0181
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0213 0.1497 0.1487
Loa Loa (eye worm) hypothetical protein 0.0035 0.0181 0.0181
Echinococcus multilocularis TNFR CD27 30 40 95 cysteine rich region 0.0025 0.0108 0.0097
Onchocerca volvulus 0.0035 0.0181 0.114
Loa Loa (eye worm) hypothetical protein 0.0035 0.0181 0.0181
Echinococcus multilocularis hypothetical protein 0.0035 0.0181 0.017
Brugia malayi Cathepsin L-like precursor 0.0012 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0035 0.0181 0.0181
Schistosoma mansoni terminal deoxycytidyl transferase 0.0013 0.0025 0.0013
Trichomonas vaginalis maltase-glucoamylase, putative 0.0025 0.0112 0.0424
Brugia malayi Protein-tyrosine phosphatase 1 0.0035 0.0181 0.0181
Echinococcus granulosus survival motor neuron protein 1 0.0164 0.1141 0.113
Schistosoma mansoni alpha glucosidase 0.0025 0.0112 0.01
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0025 0.0112 0.0424
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0035 0.0181 0.017
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0181 0.0181
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0035 0.0181 0.017
Schistosoma mansoni serine/threonine protein kinase 0.0215 0.1517 0.1507
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.0035 0.0181 1
Onchocerca volvulus 0.0019 0.0064 0.0354
Loa Loa (eye worm) hypothetical protein 0.0035 0.0181 0.0181
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0215 0.1517 0.1517
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0035 0.0181 0.0181
Echinococcus granulosus microtubule associated protein 2 0.048 0.3471 0.3464
Echinococcus granulosus TNFR CD27 30 40 95 cysteine rich region 0.0025 0.0108 0.0097
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0509 0.3688 0.3688
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0181 0.0181
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0035 0.0181 0.0181
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0035 0.0181 0.017
Brugia malayi intermediate filament protein 0.0019 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0018 0.0062 0.0062
Schistosoma mansoni hypothetical protein 0.0118 0.0796 0.0786
Echinococcus multilocularis survival motor neuron protein 1 0.0164 0.1141 0.113
Onchocerca volvulus Netrin receptor homolog 0.0016 0.0045 0.0226
Loa Loa (eye worm) transcription factor SMAD2 0.0083 0.0539 0.0539
Loa Loa (eye worm) hypothetical protein 0.0035 0.0181 0.0181
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0035 0.0181 0.0181
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0213 0.1497 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0181 0.0181
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0035 0.0181 0.0181
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0215 0.1517 0.1507
Schistosoma mansoni protein tyrosine phosphatase 0.0035 0.0181 0.017
Echinococcus granulosus lamin 0.0019 0.0064 0.0053
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0035 0.0181 0.0181
Echinococcus granulosus death domain containing protein 0.0016 0.0045 0.0034
Schistosoma mansoni hypothetical protein 0.0034 0.0174 0.0162
Loa Loa (eye worm) hypothetical protein 0.0035 0.0181 0.0181
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0035 0.0181 0.017
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0064
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0035 0.0181 0.017
Loa Loa (eye worm) hypothetical protein 0.0035 0.0181 0.0181
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0035 0.0181 0.114
Leishmania major cathepsin L-like protease 0.0044 0.0254 1
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0035 0.0181 0.017
Brugia malayi Cathepsin L-like precursor 0.0012 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0035 0.0181 0.0181
Brugia malayi MH2 domain containing protein 0.0083 0.0539 0.0539
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0035 0.0181 0.017
Trypanosoma cruzi DNA polymerase kappa, putative 0.0013 0.0025 0.0088
Loa Loa (eye worm) hypothetical protein 0.0035 0.0181 0.0181
Onchocerca volvulus 0.0034 0.0174 0.1089
Brugia malayi Death domain containing protein 0.0016 0.0045 0.0045
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0035 0.0181 0.0181
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0035 0.0181 0.017
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0035 0.0181 0.0181
Onchocerca volvulus 0.0035 0.0181 0.114
Loa Loa (eye worm) hypothetical protein 0.0016 0.0045 0.0045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0254 0.1553
Brugia malayi hypothetical protein 0.0035 0.0181 0.0181
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0035 0.0181 0.017
Onchocerca volvulus 0.0035 0.0181 0.114
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0035 0.0181 0.017
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0035 0.0181 0.017
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0213 0.1497 1
Trichomonas vaginalis pten, drome, putative 0.0035 0.0181 0.072
Onchocerca volvulus 0.0035 0.0181 0.114
Schistosoma mansoni tumor necrosis factor receptor related 0.0025 0.0108 0.0097
Echinococcus granulosus tumor necrosis factor receptor superfamily 0.0025 0.0108 0.0097
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0035 0.0181 0.017
Onchocerca volvulus 0.0035 0.0181 0.114
Onchocerca volvulus 0.0105 0.0702 0.4647
Echinococcus granulosus lamin dm0 0.0019 0.0064 0.0053
Brugia malayi Protein-tyrosine phosphatase 0.0035 0.0181 0.0181
Trichomonas vaginalis alpha-glucosidase, putative 0.0025 0.0112 0.0424
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.0105 0.0702 0.0702
Echinococcus granulosus nuclear factor of activated T cells 5 0.0241 0.1707 0.1697
Loa Loa (eye worm) hypothetical protein 0.0213 0.1497 0.1497
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0013 0.0025 0.5
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.1364 1 1
Onchocerca volvulus 0.0035 0.0181 0.114
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0181 0.0181
Loa Loa (eye worm) intermediate filament protein 0.0019 0.0064 0.0064
Loa Loa (eye worm) glutaminase 0.033 0.2364 0.2364
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0034 0.0174 0.0174
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0181 0.0181
Brugia malayi Cathepsin L-like precursor 0.0012 0.0012 0.0012
Schistosoma mansoni protein tyrosine phosphatase 0.0035 0.0181 0.017
Giardia lamblia Protein tyrosine phosphatase 0.0035 0.0181 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0254 0.1553
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0035 0.0181 1
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0213 0.1497 0.1487
Trichomonas vaginalis alpha-glucosidase, putative 0.0025 0.0112 0.0424
Echinococcus granulosus intermediate filament protein 0.0019 0.0064 0.0053
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0181 0.0181
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0254 0.1553
Leishmania major alpha glucosidase II subunit, putative 0.0025 0.0112 0.4125
Onchocerca volvulus 0.0035 0.0181 0.114
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0035 0.0181 0.0181
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0035 0.0181 0.017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0254 0.1553
Schistosoma mansoni alpha-glucosidase 0.0098 0.0646 0.0635
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0181 0.0181
Onchocerca volvulus 0.0035 0.0181 0.114
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0013 0.0025 0.0056
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0035 0.0181 0.017
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0035 0.0181 0.017
Loa Loa (eye worm) protein tyrosine phosphatase 0.0035 0.0181 0.0181
Echinococcus multilocularis tumor necrosis factor receptor superfamily 0.0025 0.0108 0.0097
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0087 0.0509
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0035 0.0181 0.017
Loa Loa (eye worm) hypothetical protein 0.0035 0.0181 0.0181
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0112 0.0671
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0013 0.0025 0.0013
Onchocerca volvulus 0.0035 0.0181 0.114
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0035 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.0035 0.0181 0.0181
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0025 0.0112 0.0424
Echinococcus granulosus dna polymerase eta 0.0031 0.0156 0.0144
Plasmodium falciparum cysteine proteinase falcipain 3 0.0012 0.0012 0.5
Trypanosoma cruzi DNA polymerase kappa, putative 0.0013 0.0025 0.0088
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0035 0.0181 0.017
Loa Loa (eye worm) hypothetical protein 0.0031 0.0156 0.0156
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0013 0.0025 0.0025
Plasmodium vivax vivapain-2 0.0012 0.0012 0.5
Echinococcus granulosus lysosomal alpha glucosidase 0.0113 0.0763 0.0752
Loa Loa (eye worm) hypothetical protein 0.0035 0.0181 0.0181
Loa Loa (eye worm) ctsf protein 0.0012 0.0012 0.0012
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0035 0.0181 0.017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0254 0.1553
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0012 0.0012 0.0012
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0035 0.0181 0.0181
Schistosoma mansoni hypothetical protein 0.0118 0.0796 0.0786
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0181 0.0181
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0.0045 0.0034
Trypanosoma cruzi cysteine peptidase, putative 0.0044 0.0254 0.1627
Loa Loa (eye worm) hypothetical protein 0.0016 0.0045 0.0045
Schistosoma mansoni glutaminase 0.033 0.2364 0.2355
Echinococcus multilocularis dna polymerase eta 0.0031 0.0156 0.0144
Onchocerca volvulus 0.0035 0.0181 0.114
Brugia malayi Protein kinase domain containing protein 0.0019 0.0065 0.0065
Onchocerca volvulus 0.0213 0.1497 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0181 0.0181
Schistosoma mansoni protein kinase 0.0509 0.3688 0.368
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0181 0.0181
Onchocerca volvulus 0.0035 0.0181 0.114
Brugia malayi glutaminase DH11.1 0.033 0.2364 0.2364
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0215 0.1517 0.1507
Loa Loa (eye worm) hypothetical protein 0.0035 0.0181 0.0181
Echinococcus granulosus netrin receptor unc 5 0.0016 0.0045 0.0034
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0035 0.0181 0.0181
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0035 0.0181 0.017
Schistosoma mansoni protein tyrosine phosphatase 0.0035 0.0181 0.017
Echinococcus granulosus Vam6:Vps39 protein 0.0213 0.1497 0.1487
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0035 0.0181 0.0181
Trypanosoma brucei DNA polymerase eta, putative 0.0031 0.0156 0.0889
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0035 0.0181 0.017
Schistosoma mansoni pcd6 interacting protein-related 0.0035 0.0181 0.017
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0035 0.0181 0.017

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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