Detailed information for compound 1574706

Basic information

Technical information
  • TDR Targets ID: 1574706
  • Name: N-[(2-chlorophenyl)methyl]-1,4-dimethyl-2,3-d ioxoquinoxaline-6-carboxamide
  • MW: 357.791 | Formula: C18H16ClN3O3
  • H donors: 1 H acceptors: 3 LogP: 2.21 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc2c(c1)n(C)c(=O)c(=O)n2C)NCc1ccccc1Cl
  • InChi: 1S/C18H16ClN3O3/c1-21-14-8-7-11(9-15(14)22(2)18(25)17(21)24)16(23)20-10-12-5-3-4-6-13(12)19/h3-9H,10H2,1-2H3,(H,20,23)
  • InChiKey: ZZBJLQLJAGXEBO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(2-chlorophenyl)methyl]-1,4-dimethyl-2,3-dioxo-quinoxaline-6-carboxamide
  • N-[(2-chlorophenyl)methyl]-1,4-dimethyl-2,3-dioxo-6-quinoxalinecarboxamide
  • N-(2-chlorobenzyl)-2,3-diketo-1,4-dimethyl-quinoxaline-6-carboxamide
  • C795-0029
  • NCGC00113299-01

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi UDP-galactopyranose mutase 0.0118 0.0106 0.1302
Onchocerca volvulus 0.0358 0.0403 0.5431
Toxoplasma gondii subtilisin SUB10 0.0358 0.0403 0.9963
Loa Loa (eye worm) hypothetical protein 0.0582 0.0681 0.0681
Schistosoma mansoni chromatin regulatory protein sir2 0.01 0.0082 0.008
Onchocerca volvulus 0.0285 0.0312 0.4201
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0049 0.002 0.0018
Loa Loa (eye worm) WD40 repeat protein 0.0285 0.0312 0.0312
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.01 0.0082 0.01
Loa Loa (eye worm) hypothetical protein 0.0037 0.0005 0.0005
Echinococcus granulosus Furin 1 0.1979 0.2414 0.2412
Schistosoma mansoni hypothetical protein 0.1621 0.197 0.1968
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0358 0.0403 0.0657
Echinococcus multilocularis protein arginine methyltransferase 0.0062 0.0036 0.0042
Giardia lamblia Hypothetical protein 0.0675 0.0796 0.2165
Brugia malayi hypothetical protein 0.0185 0.0189 0.0189
Schistosoma mansoni chromatin regulatory protein sir2 0.0675 0.0796 0.0794
Schistosoma mansoni growth factor receptor-bound protein 0.0261 0.0282 0.028
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.0082 0.0131
Echinococcus multilocularis chromatin regulatory protein sir2 0.0675 0.0796 0.0994
Brugia malayi hypothetical protein 0.0118 0.0106 0.0106
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0062 0.0036 0.0034
Loa Loa (eye worm) hypothetical protein 0.0073 0.0049 0.0049
Loa Loa (eye worm) protein arginine N-methyltransferase 0.0035 0.0002 0.0002
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0097 0.0079 0.0971
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0246 0.0264 0.0261
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0097 0.0079 0.0971
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.01 0.0082 0.008
Brugia malayi Subtilase family protein 0.0358 0.0403 0.0403
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0675 0.0796 1
Giardia lamblia Sirtuin type 2 0.01 0.0082 0.0205
Trypanosoma brucei Silent information regulator 2 related protein 3 0.01 0.0082 0.1009
Plasmodium falciparum subtilisin-like protease 1 0.0358 0.0403 0.8991
Echinococcus granulosus C type lectin domian containing protein 0.0037 0.0005 0.0003
Leishmania major arginine N-methyltransferase-like protein 0.0062 0.0036 0.0424
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0358 0.0403 0.0502
Onchocerca volvulus 0.0073 0.0049 0.0659
Schistosoma mansoni SWI/SNF complex-related 0.0049 0.002 0.0018
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.01 0.0082 0.008
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.1621 0.197 0.3224
Plasmodium falciparum protoporphyrinogen oxidase 0.0118 0.0106 0.2316
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.01 0.0082 0.1009
Trichomonas vaginalis conserved hypothetical protein 0.1621 0.197 0.3224
Trichomonas vaginalis conserved hypothetical protein 0.0358 0.0403 0.0657
Loa Loa (eye worm) prolyl oligopeptidase 0.0171 0.0171 0.0171
Mycobacterium ulcerans dehydrogenase 0.0118 0.0106 0.0725
Brugia malayi SWIRM domain containing protein 0.0049 0.002 0.002
Schistosoma mansoni chromatin regulatory protein sir2 0.01 0.0082 0.008
Brugia malayi hypothetical protein 0.0037 0.0005 0.0005
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0002 0.000005823
Echinococcus multilocularis protein kinase c epsilon type 0.0089 0.007 0.0084
Loa Loa (eye worm) transcriptional regulator 0.01 0.0082 0.0082
Schistosoma mansoni site-1 peptidase (S08 family) 0.0358 0.0403 0.0401
Onchocerca volvulus 0.0631 0.0742 1
Echinococcus multilocularis 0.0118 0.0106 0.0129
Leishmania major silent information regulator 2, putative 0.0675 0.0796 1
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0062 0.0036 0.0034
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0358 0.0403 0.0657
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0358 0.0403 0.0657
Toxoplasma gondii subtilisin SUB12 0.0358 0.0403 0.9963
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.0082 0.0131
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0118 0.0106 0.0725
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0035 0.0002 0.0000072891
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0171 0.0171 0.231
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0378 0.0427 0.5352
Giardia lamblia High cysteine membrane protein Group 2 0.2975 0.3649 1
Echinococcus granulosus lysine specific histone demethylase 1A 0.0582 0.0681 0.0679
Toxoplasma gondii histone deacetylase SIR2 0.01 0.0082 0.199
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0358 0.0403 0.0657
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0036 0.0003 0.0001
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0062 0.0036 0.0034
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0058 0.003 0.0035
Toxoplasma gondii SWIRM domain-containing protein 0.0049 0.002 0.0439
Toxoplasma gondii subtilisin SUB1 0.0358 0.0403 0.9963
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.01 0.0082 0.1009
Loa Loa (eye worm) aspartyl protease 6 0.0035 0.0002 0.0002
Schistosoma mansoni chromatin regulatory protein sir2 0.0675 0.0796 0.0794
Echinococcus granulosus protein will die slowly 0.0285 0.0312 0.031
Trichomonas vaginalis conserved hypothetical protein 0.1621 0.197 0.3224
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.01 0.0082 0.0205
Brugia malayi hypothetical protein 0.0037 0.0005 0.0005
Chlamydia trachomatis protoporphyrinogen oxidase 0.0118 0.0106 0.5
Schistosoma mansoni amine oxidase 0.0118 0.0106 0.0103
Loa Loa (eye worm) hypothetical protein 0.0035 0.0002 0.0002
Schistosoma mansoni chromatin regulatory protein sir2 0.01 0.0082 0.008
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0035 0.0002 0.0001
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0358 0.0403 0.0401
Loa Loa (eye worm) hypothetical protein 0.0051 0.0022 0.0022
Schistosoma mansoni cathepsin D (A01 family) 0.0035 0.0002 0.000005823
Brugia malayi pregnancy-associated plasma protein-A 0.0037 0.0005 0.0005
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0358 0.0403 0.505
Plasmodium falciparum subtilisin-like protease 2 0.0358 0.0403 0.8991
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0035 0.0002 0.0000095403
Echinococcus granulosus c4b binding protein beta chain 0.0037 0.0005 0.0003
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0062 0.0036 0.0754
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0002 0.000005823
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0058 0.003 0.0028
Plasmodium falciparum subtilisin-like protease 3 0.0358 0.0403 0.8991
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0358 0.0403 0.0657
Mycobacterium tuberculosis Possible oxidoreductase 0.0118 0.0106 0.0725
Giardia lamblia Transcriptional regulator, Sir2 family 0.01 0.0082 0.0205
Mycobacterium leprae Possible secreted protease 0.0358 0.0403 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0358 0.0403 0.0657
Onchocerca volvulus 0.0035 0.0003 0.0037
Loa Loa (eye worm) Carm1-pending protein 0.0035 0.0002 0.0002
Schistosoma mansoni serine/threonine protein kinase 0.0227 0.0241 0.0239
Trichomonas vaginalis conserved hypothetical protein 0.0358 0.0403 0.0657
Brugia malayi hypothetical protein 0.0037 0.0005 0.0005
Echinococcus multilocularis MAM 0.0073 0.0049 0.0058
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0358 0.0403 0.0657
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0002 0.000005823
Trypanosoma brucei subtilisin peptidase 0.0358 0.0403 0.505
Schistosoma mansoni furin-1 (S08 family) 0.3498 0.4299 0.4297
Leishmania major subtilisin-like serine peptidase 0.0358 0.0403 0.505
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0171 0.0171 0.0169
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.067 0.079 0.079
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.01 0.0082 0.1009
Brugia malayi hypothetical protein 0.0037 0.0005 0.0005
Plasmodium vivax subtilisin-like protease 1 0.0358 0.0403 0.8991
Brugia malayi Eukaryotic aspartyl protease family protein 0.0035 0.0002 0.0002
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0675 0.0796 0.0994
Onchocerca volvulus 0.0037 0.0005 0.0066
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0002 0.000005823
Toxoplasma gondii subtilisin SUB4 0.0358 0.0403 0.9963
Entamoeba histolytica hypothetical protein, conserved 0.01 0.0082 0.1009
Brugia malayi hypothetical protein 0.0037 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0631 0.0742 0.0742
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.4954 0.6104 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0675 0.0796 0.1301
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.002 0.0029
Loa Loa (eye worm) hypothetical protein 0.0035 0.0003 0.0003
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0358 0.0403 0.0657
Trypanosoma cruzi UDP-galactopyranose mutase 0.0118 0.0106 0.1302
Brugia malayi Protein arginine N-methyltransferase 0.0035 0.0002 0.0002
Brugia malayi Protein kinase domain containing protein 0.0073 0.0049 0.0049
Loa Loa (eye worm) TK/EGFR protein kinase 0.0616 0.0723 0.0723
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0358 0.0403 0.0657
Toxoplasma gondii subtilisin SUB8 0.0358 0.0403 0.9963
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.0082 0.0131
Brugia malayi NAD-dependent deacetylase SIRT1 0.01 0.0082 0.0082
Leishmania major sir2-family protein-like protein 0.01 0.0082 0.1009
Brugia malayi hypothetical protein 0.0044 0.0013 0.0013
Brugia malayi EGF-like domain containing protein 0.0039 0.0007 0.0007
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0062 0.0036 0.0055
Trypanosoma brucei SIR2-like protein 4, putative 0.01 0.0082 0.1009
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.1621 0.197 0.3224
Loa Loa (eye worm) hypothetical protein 0.0168 0.0167 0.0167
Echinococcus granulosus protein arginine methyltransferase 0.0062 0.0036 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.1621 0.197 0.3224
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0675 0.0796 1
Echinococcus multilocularis neuroendocrine convertase 2 0.5119 0.6309 0.7897
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1979 0.2414 0.3952
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0049 0.002 0.0022
Plasmodium vivax hypothetical protein, conserved 0.0118 0.0106 0.2316
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0118 0.0106 0.0725
Loa Loa (eye worm) transcriptional regulator 0.0675 0.0796 0.0796
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0002 0.000005823
Brugia malayi Integrin beta pat-3 precursor 0.1219 0.1471 0.1471
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.002 0.0029
Brugia malayi proprotein convertase 2 0.5119 0.6309 0.6309
Echinococcus granulosus furin 0.8094 1 1
Loa Loa (eye worm) integrin beta-2 0.1219 0.1471 0.1471
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.01 0.0082 0.01
Loa Loa (eye worm) hypothetical protein 0.0035 0.0003 0.0003
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.4954 0.6104 0.764
Trichomonas vaginalis conserved hypothetical protein 0.0358 0.0403 0.0657
Echinococcus multilocularis fibrillin 2 0.0039 0.0007 0.0007
Echinococcus granulosus chromatin regulatory protein sir2 0.0675 0.0796 0.0794
Brugia malayi prolyl oligopeptidase family protein 0.0058 0.003 0.003
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.0082 0.0131
Brugia malayi Kelch motif family protein 0.0205 0.0213 0.0213
Loa Loa (eye worm) hypothetical protein 0.0035 0.0002 0.0002
Loa Loa (eye worm) transcriptional regulator 0.01 0.0082 0.0082
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0097 0.0079 0.0971
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0358 0.0403 1
Toxoplasma gondii rhoptry neck protein RON9 0.0037 0.0005 0.0067
Trichomonas vaginalis conserved hypothetical protein 0.1621 0.197 0.3224
Onchocerca volvulus 0.0073 0.0049 0.0659
Leishmania major UDP-galactopyranose mutase 0.0118 0.0106 0.1302
Trichomonas vaginalis conserved hypothetical protein 0.1621 0.197 0.3224
Onchocerca volvulus 0.0039 0.0007 0.0101
Toxoplasma gondii histone deacetylase SIR2-like 0.01 0.0082 0.199
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0227 0.0241 0.0299
Trichomonas vaginalis hypothetical protein 0.0039 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0358 0.0403 0.0403
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0002 0.000005823
Loa Loa (eye worm) hypothetical protein 0.0035 0.0002 0.0002
Brugia malayi Angiotensin-converting enzyme family protein 0.067 0.079 0.079
Brugia malayi GCC2 and GCC3 family protein 0.0051 0.0022 0.0022
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.1979 0.2414 0.2412
Loa Loa (eye worm) hypothetical protein 0.0037 0.0005 0.0005
Onchocerca volvulus 0.0035 0.0002 0.003
Plasmodium vivax subtilisin-like protease 2, putative 0.0358 0.0403 0.8991
Echinococcus granulosus fibrillin 1 0.0042 0.001 0.0008
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0378 0.0427 0.5352
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0037 0.0005 0.0005
Plasmodium falciparum apical sushi protein 0.0037 0.0005 0.0059
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0358 0.0403 0.0657
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0358 0.0403 1
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0358 0.0403 0.0401
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0675 0.0796 0.0794
Trichomonas vaginalis conserved hypothetical protein 0.1621 0.197 0.3224
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0358 0.0403 0.0657
Trichomonas vaginalis conserved hypothetical protein 0.0358 0.0403 0.0657
Loa Loa (eye worm) hypothetical protein 0.0582 0.0681 0.0681
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0062 0.0036 0.0055
Schistosoma mansoni growth factor receptor-bound protein 0.0261 0.0282 0.028
Brugia malayi transcriptional regulator, Sir2 family protein 0.01 0.0082 0.0082
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0035 0.0002 0.0001
Brugia malayi protein kinase C II. 0.0089 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0039 0.0007 0.0007
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0039 0.0007 0.0009
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0358 0.0403 0.0657
Brugia malayi neuroendocrine convertase 1 precursor 0.5119 0.6309 0.6309
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1352 0.1635 0.1634
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.01 0.0082 0.1009
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0062 0.0036 0.0754
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1979 0.2414 0.3952
Loa Loa (eye worm) hypothetical protein 0.0073 0.0049 0.0049
Entamoeba histolytica PH domain containing protein kinase, putative 0.0073 0.0049 0.0593
Echinococcus multilocularis fibrillin 1 0.0055 0.0027 0.0031
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1979 0.2414 0.3952
Echinococcus multilocularis integrin beta 2 0.0903 0.1079 0.1348
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0358 0.0403 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0358 0.0403 0.0657
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0058 0.003 0.0354
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0358 0.0403 0.0403
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0358 0.0403 0.0657
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0035 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.01 0.0082 0.0082
Onchocerca volvulus 0.0037 0.0005 0.0066
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.01 0.0082 0.1009
Entamoeba histolytica hypothetical protein 0.0049 0.002 0.0222
Brugia malayi Stress-activated protein kinase jnk-1 0.0227 0.0241 0.0241
Onchocerca volvulus 0.0037 0.0005 0.0066
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.0082 0.0131
Loa Loa (eye worm) hypothetical protein 0.314 0.3854 0.3854
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0058 0.003 0.0354
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0058 0.003 0.0698
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0227 0.0241 0.0241
Onchocerca volvulus 0.0037 0.0005 0.0066
Brugia malayi transcriptional regulator, Sir2 family protein 0.01 0.0082 0.0082
Brugia malayi transcriptional regulator, Sir2 family protein 0.0675 0.0796 0.0796
Onchocerca volvulus 0.0035 0.0002 0.003
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0358 0.0403 0.0657
Echinococcus granulosus protein kinase c epsilon type 0.0089 0.007 0.0067
Brugia malayi EGF-like domain containing protein 0.0039 0.0007 0.0007
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0582 0.0681 0.085
Brugia malayi Furin-like cysteine rich region family protein 0.0616 0.0723 0.0723
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0062 0.0036 0.0055
Echinococcus granulosus protein arginine N methyltransferase 8 0.0062 0.0036 0.0034
Echinococcus multilocularis protein will die slowly 0.0285 0.0312 0.0388
Toxoplasma gondii subtilisin SUB9 0.0358 0.0403 0.9963
Loa Loa (eye worm) hypothetical protein 0.0103 0.0086 0.0086
Brugia malayi celfurPC protein 0.6473 0.7989 0.7989
Schistosoma mansoni c4b-binding protein beta chain 0.0037 0.0005 0.0003
Mycobacterium ulcerans oxidoreductase 0.0118 0.0106 0.0725
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0035 0.0003 0.0003
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0058 0.003 0.0354
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0358 0.0403 0.0657
Trichomonas vaginalis conserved hypothetical protein 0.0358 0.0403 0.0657
Brugia malayi EGF-like domain containing protein 0.0039 0.0007 0.0007
Plasmodium vivax hypothetical protein, conserved 0.0118 0.0106 0.2316
Brugia malayi Sushi domain 0.0037 0.0005 0.0005
Giardia lamblia hypothetical protein 0.0049 0.002 0.0034
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.0082 0.0131
Toxoplasma gondii aspartyl protease ASP3 0.0035 0.0002 0.0001
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0358 0.0403 0.0403
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0358 0.0403 0.0657
Brugia malayi hypothetical protein 0.0037 0.0005 0.0005
Plasmodium falciparum transcriptional regulatory protein sir2b 0.01 0.0082 0.1795
Echinococcus granulosus lysine specific histone demethylase 1A 0.0118 0.0106 0.0103
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.0082 0.0131
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.0082 0.0131
Loa Loa (eye worm) hypothetical protein 0.0039 0.0007 0.0007
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.01 0.0082 0.008
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.4954 0.6104 1
Echinococcus multilocularis protein jagged 2 0.0039 0.0007 0.0007
Onchocerca volvulus 0.0037 0.0005 0.0066
Loa Loa (eye worm) hypothetical protein 0.0037 0.0005 0.0005
Mycobacterium ulcerans monoamine oxidase 0.0118 0.0106 0.0725
Echinococcus multilocularis Furin 1 0.1979 0.2414 0.302
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0675 0.0796 0.1301
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0261 0.0282 0.0282
Loa Loa (eye worm) hypothetical protein 0.8094 1 1
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0118 0.0106 0.0725
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0036 0.0003 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.1621 0.197 0.3224
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0118 0.0106 0.2316
Loa Loa (eye worm) sirtuin 4 0.01 0.0082 0.0082
Toxoplasma gondii aspartyl protease 0.0035 0.0002 0.0001
Schistosoma mansoni chromatin regulatory protein sir2 0.01 0.0082 0.008
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.4954 0.6104 0.6104
Loa Loa (eye worm) TK/ALK protein kinase 0.0073 0.0049 0.0049
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0118 0.0106 0.2316
Echinococcus granulosus growth factor receptor bound protein 2 0.0261 0.0282 0.028
Loa Loa (eye worm) hypothetical protein 0.0118 0.0106 0.0106
Brugia malayi hypothetical protein 0.0035 0.0002 0.0002
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0675 0.0796 1
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0358 0.0403 1
Brugia malayi aspartic protease BmAsp-2, identical 0.0035 0.0002 0.0002
Brugia malayi Pepsin A precursor 0.0035 0.0002 0.0002
Plasmodium vivax subtilisin-like serine protease, putative 0.0358 0.0403 0.8991
Schistosoma mansoni site-1 peptidase (S08 family) 0.0358 0.0403 0.0401
Echinococcus granulosus MAM 0.0073 0.0049 0.0047
Loa Loa (eye worm) hypothetical protein 0.0037 0.0005 0.0005
Brugia malayi hypothetical protein 0.0037 0.0005 0.0005
Brugia malayi EGF-like domain containing protein 0.0039 0.0007 0.0007
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0002 0.000005823
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0358 0.0403 1
Echinococcus granulosus membrane bound transcription factor site 1 0.0358 0.0403 0.0401
Mycobacterium tuberculosis Conserved hypothetical protein 0.0118 0.0106 0.0725
Echinococcus granulosus fibrillin 2 0.0039 0.0007 0.0005
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.0082 0.0131
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0058 0.003 0.0354
Onchocerca volvulus 0.0166 0.0165 0.2227
Brugia malayi hypothetical protein 0.0073 0.0049 0.0049
Plasmodium vivax apical sushi protein, putative 0.0037 0.0005 0.0059
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0358 0.0403 0.0657
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0171 0.0171 0.0212
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0675 0.0796 1
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0675 0.0796 1
Brugia malayi Will die slowly protein 0.0285 0.0312 0.0312
Echinococcus granulosus integrin beta 2 0.0903 0.1079 0.1077
Echinococcus granulosus serine:threonine protein kinase N2 0.0073 0.0049 0.0047
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0358 0.0403 1
Trichomonas vaginalis conserved hypothetical protein 0.1621 0.197 0.3224
Schistosoma mansoni cathepsin D (A01 family) 0.0035 0.0002 0.000005823
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0035 0.0002 0.0002
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0002 0.000005823
Echinococcus multilocularis c4b binding protein beta chain 0.0037 0.0005 0.0003
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0358 0.0403 0.0657
Brugia malayi amine oxidase, flavin-containing family protein 0.0168 0.0167 0.0167
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0118 0.0106 0.2316
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1979 0.2414 0.3952
Schistosoma mansoni hypothetical protein 0.0073 0.0049 0.0047
Plasmodium vivax hypothetical protein, conserved 0.01 0.0082 0.1795
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0097 0.0079 0.0971
Trichomonas vaginalis WD repeat domain, putative 0.0285 0.0312 0.0507
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0582 0.0681 0.0679
Loa Loa (eye worm) hypothetical protein 0.0185 0.0189 0.0189
Toxoplasma gondii aspartyl protease ASP1 0.0035 0.0002 0.0001
Echinococcus granulosus c-Jun N-terminal kinases 0.0227 0.0241 0.0239
Schistosoma mansoni hypothetical protein 0.0073 0.0049 0.0047
Toxoplasma gondii aspartyl protease ASP5 0.0359 0.0405 1
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0378 0.0427 0.5352
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0358 0.0403 0.0657
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0358 0.0403 0.0657
Toxoplasma gondii histone lysine-specific demethylase 0.0118 0.0106 0.2568
Echinococcus multilocularis growth factor receptor bound protein 2 0.0261 0.0282 0.035
Loa Loa (eye worm) hypothetical protein 0.0097 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0037 0.0005 0.0005
Schistosoma mansoni tyrosine kinase 0.0616 0.0723 0.0721
Schistosoma mansoni septate junction protein 0.0047 0.0017 0.0014
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0058 0.003 0.0354
Loa Loa (eye worm) hypothetical protein 0.0039 0.0007 0.0007
Plasmodium falciparum plasmepsin V 0.0394 0.0448 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0013 0.0013
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.8094 1 1
Echinococcus multilocularis adam 0.0039 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.1621 0.197 0.3224
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0171 0.0171 0.0169
Toxoplasma gondii subtilisin SUB2 0.0358 0.0403 0.9963
Schistosoma mansoni memapsin-2 (A01 family) 0.0035 0.0002 0.000005823
Plasmodium vivax NAD-dependent deacetylase, putative 0.01 0.0082 0.1795
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1979 0.2414 0.3952
Echinococcus granulosus Dipeptidyl peptidase 9 0.0058 0.003 0.0028
Toxoplasma gondii subtilisin SUB6 0.0358 0.0403 0.9963
Toxoplasma gondii subtilisin SUB7 0.0358 0.0403 0.9963
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0205 0.0213 0.0213
Echinococcus granulosus neuroendocrine convertase 2 0.5119 0.6309 0.6309
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0358 0.0403 0.0401
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0071 0.0047 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.1621 0.197 0.3224
Echinococcus multilocularis 0.6473 0.7989 1
Brugia malayi SWIRM domain containing protein 0.0631 0.0742 0.0742
Entamoeba histolytica hypothetical protein 0.0097 0.0079 0.0971
Brugia malayi prolyl oligopeptidase family protein 0.0171 0.0171 0.0171
Echinococcus multilocularis protoporphyrinogen oxidase 0.0118 0.0106 0.0129
Onchocerca volvulus 0.0037 0.0005 0.0066
Loa Loa (eye worm) proprotein convertase 2 0.1979 0.2414 0.2414
Echinococcus multilocularis C type lectin domian containing protein 0.0037 0.0005 0.0003
Toxoplasma gondii subtilisin SUB11 0.0358 0.0403 0.9963
Onchocerca volvulus 0.0037 0.0005 0.0066
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0118 0.0106 0.2316
Brugia malayi aspartic protease BmAsp-1, identical 0.0035 0.0002 0.0002
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0062 0.0036 0.0837
Toxoplasma gondii rhoptry neck protein RON1 0.0037 0.0005 0.0067
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0358 0.0403 0.0657
Loa Loa (eye worm) subtilase 0.0358 0.0403 0.0403
Trypanosoma cruzi subtilisin peptidase 0.0358 0.0403 0.505
Loa Loa (eye worm) hypothetical protein 0.0118 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0037 0.0005 0.0005
Brugia malayi Carm1-pending protein 0.0035 0.0002 0.0002
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0062 0.0036 0.0042
Loa Loa (eye worm) hypothetical protein 0.0037 0.0005 0.0005
Toxoplasma gondii hypothetical protein 0.0039 0.0007 0.0132
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0358 0.0403 0.0657
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.1621 0.197 0.3224
Echinococcus multilocularis serine:threonine protein kinase N2 0.0082 0.006 0.0073
Plasmodium falciparum transcriptional regulatory protein sir2a 0.01 0.0082 0.1795
Onchocerca volvulus 0.0037 0.0005 0.0066
Schistosoma mansoni amine oxidase 0.0118 0.0106 0.0103
Schistosoma mansoni hypothetical protein 0.0285 0.0312 0.031
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0035 0.0002 0.000005823
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0358 0.0403 1
Trichomonas vaginalis hypothetical protein 0.1621 0.197 0.3224
Schistosoma mansoni chromatin regulatory protein sir2 0.0675 0.0796 0.0794
Echinococcus multilocularis membrane bound transcription factor site 1 0.0358 0.0403 0.0502
Trichomonas vaginalis conserved hypothetical protein 0.1621 0.197 0.3224
Loa Loa (eye worm) hypothetical protein 0.0073 0.0049 0.0049
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0358 0.0403 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0358 0.0403 0.0657
Onchocerca volvulus 0.0037 0.0005 0.0066
Brugia malayi hypothetical protein 0.0035 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0049 0.002 0.002
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0089 0.007 0.007
Brugia malayi hypothetical protein 0.0097 0.0079 0.0079
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0002 0.000005823
Entamoeba histolytica SWIRM domain protein 0.0049 0.002 0.0222
Echinococcus granulosus epidermal growth factor receptor 0.0616 0.0723 0.0721
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0118 0.0106 0.2568
Schistosoma mansoni serine/threonine protein kinase 0.0089 0.007 0.0067
Loa Loa (eye worm) hypothetical protein 0.0039 0.0007 0.0007
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1979 0.2414 0.3952
Echinococcus granulosus adam 0.0039 0.0007 0.0005
Toxoplasma gondii subtilisin SUB5 0.0358 0.0403 0.9963
Loa Loa (eye worm) endoprotease bli-4 0.8094 1 1
Entamoeba histolytica SWIRM domain protein 0.0049 0.002 0.0222
Plasmodium vivax plasmepsin V, putative 0.0394 0.0448 1
Schistosoma mansoni integrin beta subunit 0.0718 0.0849 0.0847
Giardia lamblia Furin precursor putative serine protease 0.1621 0.197 0.5388
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0118 0.0106 0.0103
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.01 0.0082 0.01
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0358 0.0403 1
Brugia malayi Sex muscle abnormal protein 5 0.0261 0.0282 0.0282
Echinococcus multilocularis epidermal growth factor receptor 0.0616 0.0723 0.0903
Onchocerca volvulus 0.0037 0.0005 0.0066

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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