TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 302.333 | Formula: C17H14N6
H donors: 2 H acceptors: 4 LogP: 2.24 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: c1ccc(cn1)CNc1ccnc(n1)c1ccc2c(c1)cn[nH]2
InChi: 1S/C17H14N6/c1-2-12(9-18-6-1)10-20-16-5-7-19-17(22-16)13-3-4-15-14(8-13)11-21-23-15/h1-9,11H,10H2,(H,21,23)(H,19,20,22)
InChiKey: YCEAZZWLNZYSCL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	Starlite/ChEMBL	References
Homo sapiens	CDC-like kinase 2	Starlite/ChEMBL	References
Homo sapiens	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B	Starlite/ChEMBL	References
Homo sapiens	CDC-like kinase 1	Starlite/ChEMBL	References
Homo sapiens	CDC-like kinase 4	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126990	All targets in OG5_126990
Loa Loa (eye worm)	CMGC/CLK protein kinase	Get druggable targets OG5_126990	All targets in OG5_126990
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126990	All targets in OG5_126990
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Toxoplasma gondii	cell-cycle-associated protein kinase CLK, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Leishmania major	protein kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Cryptosporidium parvum	serine/threonine kinase-1	Get druggable targets OG5_126990	All targets in OG5_126990
Giardia lamblia	Kinase, CMGC CLK	Get druggable targets OG5_126990	All targets in OG5_126990
Echinococcus granulosus	dual specificity protein kinase clk2	Get druggable targets OG5_126990	All targets in OG5_126990
Leishmania mexicana		Get druggable targets OG5_126990	All targets in OG5_126990
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_127901	All targets in OG5_127901
Leishmania braziliensis	protein kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Plasmodium vivax	serine/threonine kinase-1, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_126990	All targets in OG5_126990
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127901	All targets in OG5_127901
Leishmania infantum	protein kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127901	All targets in OG5_127901
Trypanosoma congolense	kinetoplastid kinetochore protein 10, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126990	All targets in OG5_126990
Plasmodium berghei	serine/threonine kinase-1, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126990	All targets in OG5_126990
Neospora caninum	hypothetical protein	Get druggable targets OG5_126990	All targets in OG5_126990
Candida albicans	Serine/threonine protein kinase	Get druggable targets OG5_126990	All targets in OG5_126990
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_127901	All targets in OG5_127901
Leishmania mexicana	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Theileria parva	serine/threonine protein kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Echinococcus granulosus	dual specificity	Get druggable targets OG5_127901	All targets in OG5_127901
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Trypanosoma brucei	kinetoplastid kinetochore protein 19	Get druggable targets OG5_126990	All targets in OG5_126990
Echinococcus granulosus	hypothetical protein	Get druggable targets OG5_126990	All targets in OG5_126990
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_127901	All targets in OG5_127901
Trypanosoma congolense	kinetoplastid kinetochore protein, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Candida albicans	Serine/threonine protein kinase	Get druggable targets OG5_126990	All targets in OG5_126990
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127901	All targets in OG5_127901
Trypanosoma congolense	serine/threonine-protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Echinococcus multilocularis	dual specificity	Get druggable targets OG5_127901	All targets in OG5_127901
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_127901	All targets in OG5_127901
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	Get druggable targets OG5_127901	All targets in OG5_127901
Trypanosoma brucei gambiense	protein kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Schistosoma japonicum	ko:K08823 CDC-like kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Leishmania mexicana	protein kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Plasmodium knowlesi	serine/threonine kinase-1, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma brucei	kinetoplastid kinetochore protein 10	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Leishmania donovani	serine/threonine-protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Leishmania major	protein kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Schistosoma japonicum	Serine/threonine-protein kinase Doa, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Leishmania infantum	protein kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma congolense	serine/threonine-protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Babesia bovis	protein serine/threonine kinase 1	Get druggable targets OG5_126990	All targets in OG5_126990
Plasmodium falciparum	protein serine/threonine kinase-1	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Echinococcus multilocularis	dual specificity protein kinase clk2	Get druggable targets OG5_126990	All targets in OG5_126990
Leishmania infantum	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126990	All targets in OG5_126990
Schistosoma japonicum	Serine/threonine-protein kinase minibrain, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Leishmania braziliensis	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma congolense	kinetoplastid kinetochore protein, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma brucei gambiense	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Plasmodium yoelii	protein serine/threonine kinase-1	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Echinococcus multilocularis		Get druggable targets OG5_126990	All targets in OG5_126990
Cryptosporidium hominis	serine/threonine kinase-1	Get druggable targets OG5_126990	All targets in OG5_126990

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	cell adhesion molecule	0.0113	0.0125	0.0125
Schistosoma mansoni	nephrin	0.0113	0.0125	0.3898
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0113	0.0125	0.0125
Echinococcus granulosus	hypothetical protein	0.0217	0.0312	0.0312
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0113	0.0125	0.0125
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0113	0.0125	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0125	0.0125
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0113	0.0125	0.3898
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0125	0.0125
Echinococcus granulosus	contactin	0.0113	0.0125	0.0125
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0113	0.0125	0.0125
Schistosoma mansoni	cell adhesion molecule	0.0113	0.0125	0.3898
Schistosoma mansoni	ephrin receptor	0.0155	0.0201	0.6254
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0113	0.0125	0.0125
Brugia malayi	Fibronectin type III domain containing protein	0.0113	0.0125	0.0125
Onchocerca volvulus		0.0113	0.0125	0.2398
Echinococcus multilocularis	usherin	0.0113	0.0125	0.0125
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.0217	0.0312	0.9834
Onchocerca volvulus		0.0223	0.0321	0.6152
Echinococcus multilocularis	roundabout 2	0.0113	0.0125	0.0125
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0113	0.0125	0.0125
Echinococcus multilocularis	anosmin 1	0.0113	0.0125	0.0125
Echinococcus granulosus	EG95	0.0113	0.0125	0.0125
Trypanosoma cruzi	Fibronectin type III domain containing protein, putative	0.0113	0.0125	0.395
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	0.022	0.0317	1
Loa Loa (eye worm)	hypothetical protein	0.0223	0.0321	0.0321
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0125	0.0125
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0045	0.0005	0.0157
Echinococcus granulosus	nephrin	0.0113	0.0125	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0125	0.0125
Schistosoma mansoni	nephrin	0.0113	0.0125	0.3898
Loa Loa (eye worm)	hypothetical protein	0.1635	0.2842	0.2842
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0045	0.0005	0.0157
Brugia malayi	hypothetical protein	0.0113	0.0125	0.0125
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0217	0.0312	0.9834
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0113	0.0125	0.0125
Entamoeba histolytica	protein kinase domain containing protein	0.0046	0.0006	0.0206
Echinococcus granulosus	dual specificity protein kinase clk2	0.022	0.0317	0.0317
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0113	0.0125	0.3898
Schistosoma mansoni	hypothetical protein	0.0113	0.0125	0.3898
Schistosoma mansoni	myosin-binding protein-related	0.0113	0.0125	0.3898
Onchocerca volvulus		0.0113	0.0125	0.2398
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0125	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0125	0.0125
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0113	0.0125	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0214	0.0307	0.0307
Echinococcus granulosus	neuroglian	0.0113	0.0125	0.0125
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.0217	0.0312	0.9834
Echinococcus granulosus	usherin	0.0113	0.0125	0.0125
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0045	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0125	0.0125
Echinococcus granulosus	Fibronectin type III domain containing protein	0.0113	0.0125	0.0125
Echinococcus granulosus	dual specificity	0.0217	0.0312	0.0312
Schistosoma mansoni	hemicentin	0.0113	0.0125	0.3898
Echinococcus multilocularis	Netrin receptor DCC	0.0113	0.0125	0.0125
Onchocerca volvulus		0.0113	0.0125	0.2398
Loa Loa (eye worm)	UNCoordinated family member	0.0113	0.0125	0.0125
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0113	0.0125	0.0125
Brugia malayi	Fibronectin type III domain containing protein	0.0113	0.0125	0.0125
Echinococcus multilocularis	neuroglian	0.0113	0.0125	0.0125
Trypanosoma brucei	Fibronectin type III domain containing protein, putative	0.0113	0.0125	0.395
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 32	0.0113	0.0125	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0125	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0223	0.0321	0.0321
Echinococcus multilocularis	roundabout 2	0.0113	0.0125	0.0125
Schistosoma mansoni	titin	0.0113	0.0125	0.3898
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0113	0.0125	0.0125
Schistosoma mansoni	cell adhesion molecule	0.0113	0.0125	0.3898
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0125	0.0125
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0113	0.0125	0.0125
Entamoeba histolytica	protein kinase, putative	0.0217	0.0312	1
Echinococcus multilocularis	transfer RNA-Phe	0.0113	0.0125	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0214	0.0307	0.0307
Echinococcus granulosus	Netrin receptor DCC	0.0113	0.0125	0.0125
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0113	0.0125	0.0125
Onchocerca volvulus		0.0113	0.0125	0.2398
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0113	0.0125	0.0125
Brugia malayi	myotactin form A	0.0113	0.0125	0.0125
Trichomonas vaginalis	CMGC family protein kinase	0.022	0.0317	1
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0113	0.0125	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0125	0.0125
Echinococcus granulosus	Fibronectin type III	0.0113	0.0125	0.0125
Echinococcus granulosus	activin receptor type	0.0045	0.0005	0.0005
Onchocerca volvulus		0.0113	0.0125	0.2398
Echinococcus granulosus	MAM	0.0223	0.0321	0.0321
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0113	0.0125	0.0125
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0113	0.0125	0.0125
Entamoeba histolytica	hypothetical protein	0.0217	0.0312	1
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0125	0.0125
Giardia lamblia	Kinase, CMGC CLK	0.022	0.0317	1
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0113	0.0125	0.0125
Schistosoma mansoni	titin	0.0113	0.0125	0.3898
Onchocerca volvulus		0.0113	0.0125	0.2398
Brugia malayi	hypothetical protein	0.0223	0.0321	0.0321
Trypanosoma brucei	kinetoplastid kinetochore protein 10	0.022	0.0317	1
Onchocerca volvulus		0.0113	0.0125	0.2398
Loa Loa (eye worm)	myotactin form A	0.0113	0.0125	0.0125
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0113	0.0125	0.0125
Echinococcus granulosus	anosmin 1	0.0113	0.0125	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0125	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0125	0.0125
Schistosoma mansoni	hypothetical protein	0.0223	0.0321	1
Loa Loa (eye worm)	projectin	0.0113	0.0125	0.0125
Brugia malayi	protein unc-22	0.0115	0.013	0.013
Echinococcus multilocularis	Fibronectin, type III	0.0113	0.0125	0.0125
Brugia malayi	Fibronectin type III domain containing protein	0.0113	0.0125	0.0125
Echinococcus granulosus	fibronectin type III domain-containing protein	0.0113	0.0125	0.0125
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.0113	0.0125	0.0125
Entamoeba histolytica	protein kinase domain containing protein	0.0045	0.0005	0.0159
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 30.	0.0113	0.0125	0.0125
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0113	0.0125	0.0125
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0113	0.0125	0.0125
Brugia malayi	Fibronectin type III domain containing protein	0.0113	0.0125	0.0125
Echinococcus granulosus	Netrin receptor DCC	0.0113	0.0125	0.0125
Brugia malayi	Fibronectin type III domain containing protein	0.0113	0.0125	0.0125
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0155	0.0201	0.0201
Entamoeba histolytica	protein kinase domain containing protein	0.0217	0.0312	1
Brugia malayi	Protein kinase domain containing protein	0.1901	0.3316	0.3316
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	0.022	0.0317	1
Onchocerca volvulus		0.0113	0.0125	0.2398
Echinococcus granulosus	cell adhesion molecule	0.0113	0.0125	0.0125
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0045	0.0005	0.0005
Echinococcus multilocularis	Fibronectin type III domain containing protein	0.0113	0.0125	0.0125
Echinococcus granulosus	titin	0.0115	0.013	0.013
Schistosoma mansoni	factor for adipocyte differentiation	0.0113	0.0125	0.3898
Schistosoma mansoni	serine/threonine protein kinase	0.0115	0.013	0.4053
Leishmania major	protein kinase, putative	0.022	0.0317	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0113	0.0125	0.395
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0125	0.0125
Loa Loa (eye worm)	TK protein kinase	0.5647	1	1
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0125	0.0125
Brugia malayi	Protein kinase domain containing protein	0.022	0.0317	0.0317
Plasmodium falciparum	protein serine/threonine kinase-1	0.022	0.0317	1
Schistosoma mansoni	serine/threonine protein kinase	0.0217	0.0312	0.9705
Onchocerca volvulus		0.0335	0.0522	1
Echinococcus multilocularis	tyrosine protein kinase	0.5647	1	1
Schistosoma mansoni	neuroglian	0.0113	0.0125	0.3898
Loa Loa (eye worm)	hypothetical protein	0.5604	0.9924	0.9924
Brugia malayi	myotactin form B	0.0113	0.0125	0.0125
Echinococcus multilocularis	titin	0.0115	0.013	0.013
Schistosoma mansoni	hypothetical protein	0.0113	0.0125	0.3898
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0113	0.0125	0.3898
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0113	0.0125	0.0125
Echinococcus multilocularis	roundabout 2	0.0113	0.0125	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0125	0.0125
Echinococcus multilocularis	anosmin 1	0.0113	0.0125	0.0125
Echinococcus multilocularis	MAM	0.0223	0.0321	0.0321
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0113	0.0125	0.0125
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0113	0.0125	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0223	0.0321	0.0321
Schistosoma mansoni	cell adhesion molecule	0.0113	0.0125	0.3898
Brugia malayi	Protein kinase domain containing protein	0.0217	0.0312	0.0312
Brugia malayi	Lethal protein 805	0.0113	0.0125	0.0125
Brugia malayi	Protein-tyrosine phosphatase	0.0113	0.0125	0.0125
Toxoplasma gondii	cell-cycle-associated protein kinase CLK, putative	0.022	0.0317	1
Echinococcus granulosus	anosmin 1	0.0113	0.0125	0.0125
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0113	0.0125	0.0125
Echinococcus granulosus	roundabout 2	0.0113	0.0125	0.0125
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.0113	0.0125	0.0125
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0045	0.0005	0.0005
Schistosoma mansoni	cell adhesion molecule	0.0113	0.0125	0.3898
Echinococcus granulosus	roundabout 2	0.0113	0.0125	0.0125
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0113	0.0125	0.0125
Leishmania major	hypothetical protein, conserved	0.0113	0.0125	0.395
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0113	0.0125	0.0125
Schistosoma mansoni	factor for adipocyte differentiation	0.0113	0.0125	0.3898
Brugia malayi	Lethal protein 805	0.0113	0.0125	0.0125
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0113	0.0125	0.3898
Onchocerca volvulus		0.0113	0.0125	0.2398
Echinococcus multilocularis	dual specificity protein kinase clk2	0.022	0.0317	0.0317
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0217	0.0312	0.9834
Onchocerca volvulus		0.0113	0.0125	0.2398
Echinococcus multilocularis	Netrin receptor DCC	0.0113	0.0125	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0125	0.0125
Echinococcus granulosus	G1Y162 protein	0.0113	0.0125	0.0125
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0045	0.0005	0.0157
Schistosoma mansoni	hypothetical protein	0.0223	0.0321	1
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	0.022	0.0317	1
Leishmania major	protein kinase, putative	0.022	0.0317	1
Plasmodium falciparum	protein kinase, putative	0.0045	0.0005	0.0157
Brugia malayi	hypothetical protein	0.0113	0.0125	0.0125
Schistosoma mansoni	protein kinase	0.0045	0.0005	0.0155
Onchocerca volvulus		0.0115	0.013	0.2493
Echinococcus multilocularis		0.0217	0.0312	0.0312
Schistosoma mansoni	titin	0.0115	0.013	0.4053
Schistosoma mansoni	serine/threonine protein kinase	0.022	0.0317	0.9869
Trypanosoma cruzi	Fibronectin type III domain containing protein, putative	0.0113	0.0125	0.395
Entamoeba histolytica	protein kinase, putative	0.0217	0.0312	1
Plasmodium vivax	serine/threonine kinase-1, putative	0.022	0.0317	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0113	0.0125	0.0125
Schistosoma mansoni	tripartite motif protein trim9	0.0113	0.0125	0.3898
Echinococcus granulosus	titin	0.0115	0.013	0.013
Brugia malayi	Fibronectin type III domain containing protein	0.0113	0.0125	0.0125
Echinococcus granulosus	tyrosine protein kinase	0.5647	1	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0113	0.0125	0.0125
Echinococcus multilocularis	dual specificity	0.0217	0.0312	0.0312
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0115	0.013	0.013
Schistosoma mansoni	protein tyrosine phosphatase	0.0113	0.0125	0.3898
Schistosoma mansoni	cell adhesion molecule	0.0113	0.0125	0.3898
Loa Loa (eye worm)	CMGC/CLK protein kinase	0.022	0.0317	0.0317
Schistosoma mansoni	serine/threonine protein kinase	0.022	0.0317	0.9869
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.0217	0.0312	0.0312
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0113	0.0125	0.0125
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0113	0.0125	0.0125
Schistosoma mansoni	protein kinase	0.0045	0.0005	0.0155
Loa Loa (eye worm)	TK/ALK protein kinase	0.19	0.3315	0.3315
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0113	0.0125	0.3898
Echinococcus multilocularis	Down syndrome cell adhesion molecule	0.0113	0.0125	0.0125
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0113	0.0125	0.0125
Loa Loa (eye worm)	lethal protein 805	0.0113	0.0125	0.0125
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0115	0.013	0.013
Loa Loa (eye worm)	CAMK protein kinase	0.0115	0.013	0.013
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0115	0.013	0.013
Schistosoma mansoni	hypothetical protein	0.0113	0.0125	0.3898
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0155	0.0201	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0125	0.0125
Schistosoma mansoni	protein kinase	0.0045	0.0005	0.0155
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0125	0.0125
Entamoeba histolytica	tyrosin kinase, putative	0.0046	0.0006	0.0206
Echinococcus multilocularis	activin receptor type	0.0045	0.0005	0.0005
Echinococcus multilocularis	anosmin 1	0.0113	0.0125	0.0125
Schistosoma mansoni	factor for adipocyte differentiation	0.0113	0.0125	0.3898
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0045	0.0005	0.0157
Echinococcus granulosus	Down syndrome cell adhesion molecule	0.0113	0.0125	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0125	0.0125
Echinococcus multilocularis	titin	0.0113	0.0125	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0125	0.0125
Trypanosoma brucei	kinetoplastid kinetochore protein 19	0.022	0.0317	1
Trypanosoma brucei	protein kinase, putative	0.0045	0.0005	0.0157
Echinococcus multilocularis	fibronectin type III domain-containing protein	0.0113	0.0125	0.0125
Leishmania major	protein kinase, putative	0.0045	0.0005	0.0157
Echinococcus multilocularis	Phosphotidylinositol phosphatase PTPRQ	0.0113	0.0125	0.0125
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	0.022	0.0317	1
Brugia malayi	SPRY domain containing protein	0.0113	0.0125	0.0125
Onchocerca volvulus		0.0113	0.0125	0.2398
Loa Loa (eye worm)	hypothetical protein	0.0217	0.0312	0.0312
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0113	0.0125	0.0125
Onchocerca volvulus		0.0113	0.0125	0.2398
Echinococcus granulosus	anosmin 1	0.0113	0.0125	0.0125
Echinococcus granulosus	roundabout 2	0.0113	0.0125	0.0125

Activities

Activity type	Activity value	Assay description	Source	Reference
AC50 (binding)	= 0.385 uM	PUBCHEM_BIOASSAY: MLPCN Dyrk1A - CLK1 Selectivity Assay Measured in Biochemical System Using Plate Reader - 2124-05_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504442]	ChEMBL.	No reference
IC50 (binding)	= 150 nM	Inhibition of CLK4 (unknown origin) by bioluminescence assay	ChEMBL.	23642479
IC50 (binding)	= 179 nM	Inhibition of DYRK1B (unknown origin)	ChEMBL.	23642479
IC50 (binding)	= 349 nM	Inhibition of DYRK1A (unknown origin)	ChEMBL.	23642479
IC50 (binding)	= 574 nM	Inhibition of CLK4 (unknown origin)	ChEMBL.	23642479
IC50 (binding)	= 650 nM	Inhibition of DYRK1A (unknown origin) by bioluminescence assay	ChEMBL.	23642479
IC50 (binding)	= 665 nM	Inhibition of CLK2 (unknown origin)	ChEMBL.	23642479
IC50 (binding)	= 964 nM	Inhibition of CLK1 (unknown origin)	ChEMBL.	23642479

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1884711

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1582305