Detailed information for compound 1589974

Basic information

Technical information
  • TDR Targets ID: 1589974
  • Name: (2S)-2-(naphthalen-2-ylsulfonylamino)-2-pheny lacetic acid
  • MW: 341.381 | Formula: C18H15NO4S
  • H donors: 2 H acceptors: 4 LogP: 3.43 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)[C@H](c1ccccc1)NS(=O)(=O)c1ccc2c(c1)cccc2
  • InChi: 1S/C18H15NO4S/c20-18(21)17(14-7-2-1-3-8-14)19-24(22,23)16-11-10-13-6-4-5-9-15(13)12-16/h1-12,17,19H,(H,20,21)/t17-/m0/s1
  • InChiKey: UDTRIHNSADWKRA-KRWDZBQOSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S)-2-(2-naphthylsulfonylamino)-2-phenyl-acetic acid
  • (2S)-2-(2-naphthylsulfonylamino)-2-phenylacetic acid
  • (2S)-2-(naphthalen-2-ylsulfonylamino)-2-phenyl-ethanoic acid
  • NCI60_008530
  • NSC626938

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis snurportin 1 0.0337 0.3845 0.3833
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0142 0.0445
Trypanosoma brucei Xaa-Pro aminopeptidase, putative 0.0038 0.0159 0.0411
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0156 0.0137
Trichomonas vaginalis alpha-glucosidase, putative 0.0075 0.0611 0.1808
Leishmania major glycosyl hydrolase-like protein 0.0028 0.0029 0.0092
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0028 0.0029 0.0087
Entamoeba histolytica Xaa-Pro dipeptidase, putative 0.0038 0.0159 0.0499
Onchocerca volvulus 0.0038 0.0156 0.0402
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0038 0.0159 0.0471
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0142 0.042
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0156 0.0137
Trypanosoma cruzi aminopeptidase P, putative 0.0038 0.0159 0.0499
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0156 0.0137
Mycobacterium ulcerans glutaminase 0.0299 0.3379 1
Trypanosoma cruzi aldo/keto reductase, putative 0.0038 0.0156 0.049
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0038 0.0159 0.0411
Trypanosoma brucei aldo-keto reductase, putative 0.0038 0.0156 0.0402
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.0893 0.0876
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0081 0.0682 0.2138
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0038 0.0156 0.0462
Loa Loa (eye worm) DNA-binding protein 0.0038 0.0159 0.0339
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0142 0.042
Onchocerca volvulus 0.0196 0.21 0.6551
Echinococcus multilocularis lysosomal alpha glucosidase 0.0338 0.3862 0.385
Chlamydia trachomatis methionine aminopeptidase 0.0064 0.0474 1
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.0064 0.0474 0.1284
Trichomonas vaginalis sucrase-isomaltase, putative 0.0075 0.0611 0.1808
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0038 0.0159 0.0499
Mycobacterium tuberculosis Probable oxidoreductase 0.0038 0.0156 0.0283
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0156 0.0356
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.1203 0.3062
Onchocerca volvulus 0.0037 0.0142 0.0357
Trichomonas vaginalis esterase, putative 0.0037 0.0142 0.042
Schistosoma mansoni hypothetical protein 0.0066 0.0493 0.1112
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0293 0.3307 0.3294
Schistosoma mansoni hypothetical protein 0.0066 0.0493 0.1112
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0142 0.042
Schistosoma mansoni pol-related 0.0038 0.0156 0.0219
Echinococcus multilocularis geminin 0.0186 0.1974 0.1959
Schistosoma mansoni hypothetical protein 0.0142 0.1432 0.3601
Onchocerca volvulus 0.0038 0.0156 0.0402
Plasmodium falciparum proliferation-associated protein 2g4, putative 0.0038 0.0159 0.0274
Loa Loa (eye worm) glutaminase 0.0299 0.3379 0.874
Schistosoma mansoni polycystin 1-related 0.0059 0.0417 0.091
Schistosoma mansoni chromatin-specific transcription elongation factor 140 kDa subunit (M24 family) 0.0038 0.0159 0.0227
Brugia malayi Calcitonin receptor-like protein seb-1 0.0207 0.2241 0.577
Brugia malayi Glycosyl hydrolases family 31 protein 0.0075 0.0611 0.1518
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.0156 0.0331
Onchocerca volvulus Methionine aminopeptidase 2 homolog 0.0284 0.3191 1
Brugia malayi beta-lactamase 0.0037 0.0142 0.0294
Brugia malayi metallopeptidase family M24 containing protein 0.0038 0.0159 0.0339
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0207 0.2241 0.577
Onchocerca volvulus 0.0038 0.0156 0.0402
Entamoeba histolytica aldose reductase, putative 0.0038 0.0156 0.049
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0132 0.039
Toxoplasma gondii ABC1 family protein 0.0037 0.0142 0.0219
Wolbachia endosymbiont of Brugia malayi Xaa-Pro aminopeptidase 0.0038 0.0159 0.08
Echinococcus multilocularis xaa Pro dipeptidase 0.0038 0.0159 0.014
Echinococcus granulosus lysosomal alpha glucosidase 0.0338 0.3862 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0142 0.0123
Trypanosoma brucei methionine aminopeptidase 2, putative 0.0284 0.3191 1
Brugia malayi MH2 domain containing protein 0.0123 0.1203 0.3062
Toxoplasma gondii aldose reductase, putative 0.0038 0.0156 0.0265
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.0156 0.0331
Mycobacterium leprae Probable lipase LipE 0.0037 0.0142 0.2696
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0075 0.0611 0.1724
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0038 0.0159 0.0471
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0142 0.0226
Echinococcus granulosus xaa Pro dipeptidase 0.0038 0.0159 0.0364
Echinococcus multilocularis xaa pro aminopeptidase 0.0038 0.0159 0.014
Echinococcus multilocularis xaa Pro dipeptidase 0.0038 0.0159 0.014
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0029 0.0087
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0038 0.0156 0.3009
Trichomonas vaginalis alpha-glucosidase, putative 0.0075 0.0611 0.1808
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0132 0.039
Brugia malayi Inositol-1 0.0036 0.0132 0.0268
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0075 0.0611 0.1808
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0142 0.2696
Echinococcus multilocularis aldo keto reductase 0.0038 0.0156 0.0137
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.0893 0.0876
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0029 0.0087
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0156 0.0356
Loa Loa (eye worm) inositol-1 0.0036 0.0132 0.0268
Trichomonas vaginalis alpha-glucosidase, putative 0.0075 0.0611 0.1808
Echinococcus granulosus lipoxygenase domain containing protein 0.0059 0.0417 0.1034
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0075 0.0611 0.1915
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0066 0.0493 0.0474
Plasmodium vivax methionine aminopeptidase 1a, putative 0.0064 0.0474 0.1284
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0893 0.2173
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0156 0.0137
Schistosoma mansoni glutaminase 0.0299 0.3379 0.8765
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0284 0.3191 1
Brugia malayi hypothetical protein 0.0232 0.2551 0.6581
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0156 0.0356
Trypanosoma brucei prostaglandin f synthase 0.0038 0.0156 0.0402
Echinococcus granulosus neutral alpha glucosidase AB 0.0075 0.0611 0.154
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) 0.0064 0.0474 1
Echinococcus multilocularis methionyl aminopeptidase 2 0.0284 0.3191 0.3177
Leishmania major aminopeptidase P, putative,metallo-peptidase, Clan MG, Family M24 0.0038 0.0159 0.0499
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.0038 0.0159 0.0227
Loa Loa (eye worm) latrophilin receptor protein 2 0.0066 0.0493 0.121
Trypanosoma cruzi Metallopeptidase family M24, putative 0.0038 0.0159 0.0499
Entamoeba histolytica aldose reductase, putative 0.0038 0.0156 0.049
Mycobacterium ulcerans oxidoreductase 0.0038 0.0156 0.0075
Onchocerca volvulus 0.0059 0.0417 0.1226
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0156 0.0356
Mycobacterium ulcerans lipase LipD 0.0037 0.0142 0.0031
Echinococcus multilocularis FACT complex subunit SPT16 0.0038 0.0159 0.014
Schistosoma mansoni aminopeptidase P1 (M24 family) 0.0038 0.0159 0.0227
Schistosoma mansoni hypothetical protein 0.0059 0.0417 0.091
Brugia malayi beta-lactamase family protein 0.0037 0.0142 0.0294
Trypanosoma brucei methionine aminopeptidase, putative 0.0081 0.0682 0.2066
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) 0.0064 0.0474 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0028 0.0029 0.0087
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0156 0.0462
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.0064 0.0474 0.1284
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0156 0.0462
Schistosoma mansoni inositol monophosphatase 0.0036 0.0132 0.0154
Loa Loa (eye worm) hypothetical protein 0.0207 0.2241 0.577
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0132 0.0113
Brugia malayi Glycosyl hydrolases family 31 protein 0.0338 0.3862 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0269 0.0625
Echinococcus multilocularis aldo keto reductase 0.0038 0.0156 0.0137
Loa Loa (eye worm) oxidoreductase 0.0038 0.0156 0.0331
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0207 0.2241 0.577
Loa Loa (eye worm) hypothetical protein 0.0037 0.0142 0.0294
Echinococcus granulosus importin subunit beta 1 0.0032 0.0074 0.0141
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0038 0.0159 0.0499
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.0156 0.0331
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0337 0.3845 0.9956
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.2551 0.2537
Trichomonas vaginalis alpha-glucosidase, putative 0.0075 0.0611 0.1808
Leishmania major hypothetical protein, conserved 0.0037 0.0142 0.0445
Echinococcus multilocularis aldo keto reductase 0.0038 0.0156 0.0137
Brugia malayi initiation factor 2-associated protein. 0.0284 0.3191 0.8249
Echinococcus granulosus lipoxygenase domain containing protein 0.0059 0.0417 0.1034
Entamoeba histolytica aldose reductase, putative 0.0038 0.0156 0.049
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0038 0.0159 0.0471
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0142 0.0357
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0156 0.0137
Mycobacterium ulcerans methionine aminopeptidase 0.0064 0.0474 0.1054
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0066 0.0493 0.1232
Trypanosoma brucei Metallopeptidase family M24, putative 0.0038 0.0159 0.0411
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0038 0.0159 0.0471
Brugia malayi DNA-binding protein, 42 kDa containing protein 0.0038 0.0159 0.0339
Echinococcus granulosus Xaa Pro aminopeptidase 3 0.0038 0.0159 0.0364
Leishmania major prostaglandin f synthase, putative 0.0038 0.0156 0.049
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0156 0.0462
Brugia malayi Methionine aminopeptidase protein type I 0.0081 0.0682 0.1704
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0038 0.0156 0.049
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0237 0.261 1
Loa Loa (eye worm) doublecortin family protein 0.0059 0.0417 0.1011
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.0893 0.2274
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0156 0.0462
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0284 0.3191 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0893 0.2173
Loa Loa (eye worm) hypothetical protein 0.0037 0.0142 0.0294
Loa Loa (eye worm) oxidoreductase 0.0038 0.0156 0.0331
Leishmania major hypothetical protein, conserved 0.0038 0.0159 0.0499
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0038 0.0156 0.0462
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0038 0.0159 0.0471
Loa Loa (eye worm) oxidoreductase 0.0038 0.0156 0.0331
Plasmodium vivax peptidase, putative 0.0038 0.0159 0.0274
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0156 0.0356
Brugia malayi Doublecortin family protein 0.0059 0.0417 0.1011
Trichomonas vaginalis maltase-glucoamylase, putative 0.0075 0.0611 0.1808
Plasmodium falciparum methionine aminopeptidase 1c, putative 0.0038 0.0159 0.0274
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0142 0.0181
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0156 0.0137
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0156 0.0462
Schistosoma mansoni peptidase 0.0038 0.0159 0.0227
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0028 0.0029 0.0087
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0156 0.0137
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0066 0.0493 0.121
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0156 0.0462
Loa Loa (eye worm) hypothetical protein 0.0038 0.0159 0.0339
Echinococcus granulosus hypothetical protein 0.0038 0.0156 0.0356
Loa Loa (eye worm) oxidoreductase 0.0038 0.0156 0.0331
Plasmodium falciparum methionine aminopeptidase 2 0.0284 0.3191 1
Echinococcus granulosus xaa pro aminopeptidase 0.0038 0.0159 0.0364
Mycobacterium leprae Probable cytoplasmic peptidase PepQ 0.0038 0.0159 0.3074
Trichomonas vaginalis aldo/keto reductase, putative 0.0038 0.0156 0.0462
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0064 0.0474 0.0455
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0156 0.0462
Onchocerca volvulus 0.0038 0.0156 0.0402
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0029 0.0087
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0156 0.0356
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0284 0.3191 0.9443
Brugia malayi Latrophilin receptor protein 2 0.0066 0.0493 0.121
Schistosoma mansoni alpha-glucosidase 0.0291 0.328 0.8502
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0142 0.0181
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0142 0.0294
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0142 0.0294
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.0064 0.0474 0.1541
Trypanosoma brucei glucosidase, putative 0.0075 0.0611 0.184
Leishmania major alpha glucosidase II subunit, putative 0.0075 0.0611 0.1915
Schistosoma mansoni lipoxygenase 0.0293 0.3307 0.8575
Schistosoma mansoni hypothetical protein 0.0337 0.3845 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0156 0.0137
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0075 0.0611 0.1518
Loa Loa (eye worm) hypothetical protein 0.0038 0.0159 0.0339
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0132 0.0413
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0156 0.0137
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0132 0.0413
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.0081 0.0682 0.1952
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.0081 0.0682 0.2066
Loa Loa (eye worm) hypothetical protein 0.0232 0.2551 0.6581
Echinococcus granulosus aldo keto reductase 0.0038 0.0156 0.0356
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.0081 0.0682 0.2066
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.0156 0.0331
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0156 0.0462
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0156 0.0462
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0064 0.0474 0.1062
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0132 0.0324
Echinococcus granulosus FACT complex subunit SPT16 0.0038 0.0159 0.0364
Loa Loa (eye worm) hypothetical protein 0.0032 0.0074 0.0116
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0142 0.0319
Onchocerca volvulus 0.0038 0.0159 0.0411
Leishmania major transcription factor-like protein 0.0038 0.0159 0.0499
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0156 0.0356
Schistosoma mansoni hypothetical protein 0.0066 0.0493 0.1112
Echinococcus granulosus geminin 0.0186 0.1974 0.5088
Echinococcus granulosus aldo keto reductase 0.0038 0.0156 0.0356
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0075 0.0611 0.1915
Echinococcus multilocularis RUN 0.0059 0.0417 0.0398
Plasmodium vivax methionine aminopeptidase 1c, putative 0.0038 0.0159 0.0274
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0038 0.0159 0.0471
Brugia malayi metallopeptidase family M24 containing protein 0.0038 0.0159 0.0339
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0132 0.0413
Treponema pallidum methionine aminopeptidase (map) 0.0064 0.0474 1
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.0038 0.0159 0.0499
Schistosoma mansoni hypothetical protein 0.0186 0.1974 0.504
Loa Loa (eye worm) glutaminase 2 0.0299 0.3379 0.874
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0284 0.3191 0.9443
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0142 0.0226
Toxoplasma gondii methionine aminopeptidase 0.0081 0.0682 0.1952
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0142 0.0226
Loa Loa (eye worm) methionine aminopeptidase type I 0.0081 0.0682 0.1704
Echinococcus multilocularis neutral alpha glucosidase AB 0.0075 0.0611 0.0593
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0081 0.0682 0.2138
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0284 0.3191 0.9443
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0066 0.0493 0.1232
Echinococcus multilocularis Proliferation associated protein 2G4 0.0038 0.0159 0.014
Echinococcus granulosus aldo keto reductase 0.0038 0.0156 0.0356
Echinococcus granulosus methionyl aminopeptidase 2 0.0284 0.3191 0.8254
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.0064 0.0474 1
Plasmodium vivax methionine aminopeptidase 1b, putative 0.0081 0.0682 0.1952
Echinococcus granulosus xaa Pro dipeptidase 0.0038 0.0159 0.0364
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0038 0.0156 0.049
Echinococcus multilocularis GPCR, family 2 0.0066 0.0493 0.0474
Plasmodium falciparum FACT complex subunit SPT16, putative 0.0038 0.0159 0.0274
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0028 0.0029 0.0092
Mycobacterium ulcerans methionine aminopeptidase MapB 0.0064 0.0474 0.1054
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0081 0.0682 0.0664
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0156 0.0462
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0142 0.0226
Plasmodium vivax FACT complex subunit SPT16, putative 0.0038 0.0159 0.0274
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0074 0.0141
Schistosoma mansoni Xaa-Pro dipeptidase (M24 family) 0.0038 0.0159 0.0227
Mycobacterium ulcerans dipeptidase PepE 0.0038 0.0159 0.0084
Schistosoma mansoni hypothetical protein 0.0047 0.0269 0.0517
Toxoplasma gondii proliferation-associated protein 2G4, putative 0.0038 0.0159 0.0274
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0156 0.0356
Trichomonas vaginalis alpha-glucosidase, putative 0.0075 0.0611 0.1808
Onchocerca volvulus 0.0038 0.0156 0.0402
Echinococcus multilocularis lipoxygenase domain containing protein 0.0059 0.0417 0.0398
Onchocerca volvulus 0.0038 0.0156 0.0402
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0038 0.0159 0.0471
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0038 0.0159 0.0411
Entamoeba histolytica aminopeptidase, putative 0.0038 0.0159 0.0499
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0156 0.0462
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0142 0.042
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0038 0.0156 0.0462
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.0038 0.0159 0.0227
Echinococcus granulosus Proliferation associated protein 2G4 0.0038 0.0159 0.0364
Loa Loa (eye worm) metallopeptidase family M24 containing protein 0.0038 0.0159 0.0339
Echinococcus granulosus RUN 0.0059 0.0417 0.1034
Brugia malayi glutaminase DH11.1 0.0299 0.3379 0.874
Entamoeba histolytica hypothetical protein, conserved 0.0038 0.0159 0.0499
Onchocerca volvulus FACT complex subunit SPT16 homolog 0.0038 0.0159 0.0411
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0074 0.0054
Schistosoma mansoni survival motor neuron protein 0.0047 0.0269 0.0517
Trichomonas vaginalis aldo/keto reductase, putative 0.0038 0.0156 0.0462
Mycobacterium ulcerans beta-lactamase 0.0037 0.0142 0.0031
Giardia lamblia Methionine aminopeptidase 0.0284 0.3191 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0338 0.3862 0.385
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0081 0.0682 0.2138
Mycobacterium tuberculosis Conserved protein 0.0037 0.0142 0.0226
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0156 0.0137
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0142 0.0226
Toxoplasma gondii creatinase domain-containing protein 0.0038 0.0159 0.0274
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0066 0.0493 0.0474
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0085 0.144
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0038 0.0159 0.0499
Onchocerca volvulus Dipeptidase C homolog 0.0038 0.0159 0.0411
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0029 0.0087
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.0064 0.0474 0.1541
Schistosoma mansoni rab6-interacting 0.0059 0.0417 0.091
Mycobacterium tuberculosis Conserved protein 0.0037 0.0142 0.0226
Echinococcus multilocularis aldo keto reductase 0.0038 0.0156 0.0137
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0075 0.0611 0.1808
Trypanosoma cruzi Metallopeptidase family M24/FACT complex subunit (SPT16/CDC68)/Histone chaperone Rttp106-like, putative 0.0038 0.0159 0.0499
Loa Loa (eye worm) beta-lactamase 0.0037 0.0142 0.0294
Plasmodium vivax methionine aminopeptidase 2, putative 0.0284 0.3191 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0028 0.0029 0.0092
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0038 0.0159 0.0471
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0156 0.0137
Plasmodium vivax multidomain scavenger receptor, putative 0.0059 0.0417 0.1101
Mycobacterium ulcerans hypothetical protein 0.0037 0.0142 0.0031
Trypanosoma cruzi aldo-keto reductase 0.0038 0.0156 0.049
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0132 0.039
Schistosoma mansoni inositol monophosphatase 0.0036 0.0132 0.0154
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0156 0.0356
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0142 0.0219
Mycobacterium tuberculosis Probable cytoplasmic peptidase PepQ 0.0038 0.0159 0.0294
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0132 0.0186
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0611 0.1915
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0098 0.0893 0.2254
Echinococcus multilocularis Polycystic kidney disease protein 0.0059 0.0417 0.0398
Brugia malayi latrophilin 2 splice variant baaae 0.0142 0.1432 0.3659
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0028 0.0029 0.0092
Entamoeba histolytica methionine aminopeptidase, putative 0.0284 0.3191 1
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0038 0.0159 0.0499
Plasmodium falciparum LCCL domain-containing protein 0.0059 0.0417 0.1101
Loa Loa (eye worm) hypothetical protein 0.0142 0.1432 0.3659
Loa Loa (eye worm) hypothetical protein 0.0037 0.0142 0.0294
Loa Loa (eye worm) hypothetical protein 0.0066 0.0493 0.121
Leishmania major aldo-keto reductase-like protein 0.0038 0.0156 0.049
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0064 0.0474 0.1062
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0142 0.0226
Toxoplasma gondii methionine aminopeptidase 0.0064 0.0474 0.1284
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0142 0.0226
Trichomonas vaginalis glutaminase, putative 0.0299 0.3379 1
Brugia malayi Importin beta-1 subunit 0.0032 0.0074 0.0116
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0338 0.3862 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0038 0.0156 0.0462
Trypanosoma brucei Facilitates chromatin transcription complex subunit spt16 0.0038 0.0159 0.0411
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0142 0.0445
Brugia malayi beta-lactamase family protein 0.0037 0.0142 0.0294
Echinococcus granulosus snurportin 1 0.0337 0.3845 0.9956
Echinococcus multilocularis Xaa Pro aminopeptidase 3 0.0038 0.0159 0.014
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0132 0.0292
Giardia lamblia Xaa-Pro dipeptidase 0.0038 0.0159 0.001
Onchocerca volvulus 0.0037 0.0142 0.0357
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0038 0.0159 0.0471
Loa Loa (eye worm) hypothetical protein 0.0059 0.0417 0.1011
Onchocerca volvulus 0.0037 0.0142 0.0357
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0038 0.0159 0.0499
Loa Loa (eye worm) hypothetical protein 0.0037 0.0142 0.0294
Plasmodium falciparum aminopeptidase P 0.0038 0.0159 0.0274
Schistosoma mansoni methionyl aminopeptidase 2 (M24 family) 0.0284 0.3191 0.8266
Mycobacterium tuberculosis Conserved protein 0.0037 0.0142 0.0226
Giardia lamblia Xaa-Pro dipeptidase 0.0038 0.0159 0.001
Schistosoma mansoni alpha-glucosidase 0.0291 0.328 0.8502
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0611 0.1915
Mycobacterium tuberculosis Dipeptidase PepE 0.0038 0.0159 0.0294
Plasmodium vivax proliferation-associated protein 2g4, putative 0.0038 0.0159 0.0274
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0142 0.0031
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.1203 0.3062
Loa Loa (eye worm) hypothetical protein 0.0037 0.0142 0.0294
Loa Loa (eye worm) hypothetical protein 0.0038 0.0159 0.0339
Leishmania major methionine aminopeptidase 2, putative 0.0284 0.3191 1
Echinococcus multilocularis methionine aminopeptidase, type I 0.0038 0.0159 0.014
Schistosoma mansoni loxhd1 0.0059 0.0417 0.091
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0098 0.0893 0.2254
Mycobacterium ulcerans dipeptidase 0.0038 0.0159 0.0084
Echinococcus granulosus GPCR family 2 0.0066 0.0493 0.1232
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0284 0.3191 0.9443
Schistosoma mansoni hypothetical protein 0.0066 0.0493 0.1112
Toxoplasma gondii transcriptional elongation factor FACT140 0.0038 0.0159 0.0274
Toxoplasma gondii peptidase D, putative 0.0038 0.0159 0.0274
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0284 0.3191 1
Trypanosoma cruzi Metallopeptidase family M24, putative 0.0038 0.0159 0.0499
Brugia malayi RNA, U transporter 1 0.009 0.0792 0.1991
Toxoplasma gondii methionine aminopeptidase 2, putative 0.0284 0.3191 1
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0038 0.0159 0.0499
Trypanosoma cruzi aminopeptidase P1, putative 0.0038 0.0159 0.0499
Schistosoma mansoni rab6-interacting 0.0059 0.0417 0.091
Onchocerca volvulus 0.0059 0.0417 0.1226
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0074 0.0141
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.0893 0.2274
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.0081 0.0682 0.1725
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0293 0.3307 0.8557
Loa Loa (eye worm) hypothetical protein 0.0059 0.0417 0.1011
Loa Loa (eye worm) oxidoreductase 0.0038 0.0156 0.0331
Schistosoma mansoni aldo-keto reductase 0.0038 0.0156 0.0219
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0156 0.0462
Schistosoma mansoni aminopeptidase P homologue (M24 family) 0.0038 0.0159 0.0227
Brugia malayi hypothetical protein 0.0059 0.0417 0.1011
Loa Loa (eye worm) hypothetical protein 0.0037 0.0142 0.0294
Echinococcus granulosus methionine aminopeptidase type I 0.0038 0.0159 0.0364
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0893 0.2173
Mycobacterium ulcerans aminopeptidase 0.0038 0.0159 0.0084
Mycobacterium ulcerans cytoplasmic peptidase PepQ 0.0038 0.0159 0.0084
Brugia malayi metallopeptidase family M24 containing protein 0.0038 0.0159 0.0339
Onchocerca volvulus 0.0047 0.0269 0.0758
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0142 0.0031
Loa Loa (eye worm) hypothetical protein 0.0038 0.0156 0.0331
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0029 0.0087
Brugia malayi hypothetical protein 0.0059 0.0417 0.1011
Schistosoma mansoni alpha glucosidase 0.0075 0.0611 0.1425
Schistosoma mansoni lipoxygenase 0.0187 0.1988 0.5077
Echinococcus multilocularis lipoxygenase domain containing protein 0.0059 0.0417 0.0398
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.0038 0.0159 0.0499
Schistosoma mansoni hypothetical protein 0.0186 0.1974 0.504
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0142 0.042
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.2551 0.6589
Entamoeba histolytica peptidase, putative 0.0038 0.0159 0.0499
Schistosoma mansoni aldo-keto reductase 0.0038 0.0156 0.0219
Loa Loa (eye worm) initiation factor 2-associated protein 0.0284 0.3191 0.8249
Echinococcus granulosus Polycystic kidney disease protein 0.0059 0.0417 0.1034
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0132 0.0413

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) = 230 uM Inhibitory concentration of the compound against aldose reductase obtained from rat lens ChEMBL. 2491890

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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