Detailed information for compound 1595187

Basic information

Technical information
  • TDR Targets ID: 1595187
  • Name: 3,3-Dibromo-1,5,2,4-dioxadithiepane 2,2,4,4-t etraoxide
  • MW: 359.998 | Formula: C3H4Br2O6S2
  • H donors: 0 H acceptors: 4 LogP: 0.54 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: BrC1(Br)S(=O)(=O)OCCOS1(=O)=O
  • InChi: 1S/C3H4Br2O6S2/c4-3(5)12(6,7)10-1-2-11-13(3,8)9/h1-2H2
  • InChiKey: AAIAQPAOSBKULH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • NCI60_016747
  • AIDS-139333
  • AIDS139333
  • NSC648304

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Protein kinase domain containing protein 0.0261 0.5011 0.4991
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0685 0.1632
Schistosoma mansoni tyrosine kinase 0.006 0.0558 0.0828
Brugia malayi SRC-1 0.0086 0.1125 0.1089
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0038 0.0068 0.0031
Brugia malayi Protein kinase domain containing protein 0.0043 0.0169 0.013
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0214 0.3976 0.4855
Schistosoma mansoni ste20-related kinase 0.0184 0.3315 0.492
Echinococcus granulosus roundabout 2 0.0084 0.1077 0.1146
Loa Loa (eye worm) AGC/PKA protein kinase 0.0049 0.0316 0.0277
Brugia malayi bone morphogenetic protein type 1 receptor 0.0092 0.1271 0.1236
Schistosoma mansoni wiskott-aldrich syndrome protein 0.0106 0.1586 0.2354
Brugia malayi P21-Rho-binding domain containing protein 0.0106 0.1586 0.1552
Loa Loa (eye worm) TK/FAK protein kinase 0.0281 0.5453 0.5435
Echinococcus multilocularis PAK box P21 Rho binding 0.0115 0.1771 0.2136
Echinococcus granulosus defective proboscis extension response 0.0045 0.0231 0.0211
Schistosoma mansoni cell adhesion molecule 0.0038 0.0068 0.0101
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0049 0.0316 0.0341
Schistosoma mansoni growth factor receptor-bound protein 0.0037 0.004 0.0059
Schistosoma mansoni cell adhesion molecule 0.0069 0.0751 0.1115
Echinococcus multilocularis Immunoglobulin 0.0045 0.0231 0.0236
Entamoeba histolytica protein kinase, putative 0.0115 0.1771 0.431
Echinococcus multilocularis neural Wiskott Aldrich syndrome protein 0.0106 0.1586 0.1907
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0316 0.0696
Echinococcus multilocularis roundabout 2 0.0038 0.0068 0.0035
Entamoeba histolytica hypothetical protein 0.0106 0.1586 0.3848
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0103 0.1513 0.9235
Brugia malayi Protein kinase domain containing protein 0.007 0.0777 0.074
Loa Loa (eye worm) hypothetical protein 0.0074 0.0862 0.0826
Echinococcus multilocularis neuroglian 0.006 0.0557 0.0637
Loa Loa (eye worm) TKL/STKR/TYPE2 protein kinase 0.0071 0.0797 0.076
Echinococcus multilocularis protein kinase c iota type 0.0041 0.0137 0.012
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0108 0.1612 0.1579
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0485 1 1
Brugia malayi Hr1 repeat family protein 0.0166 0.2907 0.2878
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0202 0.3702 0.4518
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0086 0.1125 0.1338
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0049 0.0316 0.0305
Echinococcus multilocularis myosin iiia 0.0061 0.0581 0.0667
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0473 0.9721 0.972
Brugia malayi serine/threonine-protein kinase 6 0.0066 0.0685 0.0647
Echinococcus granulosus epidermal growth factor receptor 0.0079 0.0978 0.1036
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.01 0.1434 0.8623
Loa Loa (eye worm) hypothetical protein 0.0038 0.0068 0.0028
Schistosoma mansoni vam6/vps39 related 0.0103 0.1513 0.2246
Brugia malayi hypothetical protein 0.0043 0.0169 0.013
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.013 0.2107 0.2076
Schistosoma mansoni tyrosine kinase 0.0056 0.0459 0.0682
Loa Loa (eye worm) TK protein kinase 0.0236 0.4467 0.4444
Trichomonas vaginalis CMGC family protein kinase 0.007 0.0777 0.1868
Echinococcus granulosus tyrosine protein kinase Src64B 0.0086 0.1125 0.1199
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0049 0.0316 0.1861
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0111 0.1698 0.2046
Entamoeba histolytica protein kinase, putative 0.0118 0.1849 0.4504
Brugia malayi Protein kinase domain containing protein 0.0068 0.0732 0.0695
Schistosoma mansoni vesicular amine transporter 0.0045 0.0231 0.0343
Echinococcus granulosus tyrosine protein kinase Fyn 0.0086 0.1125 0.1199
Echinococcus granulosus dual specificity 0.01 0.1434 0.154
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0338 0.6737 0.6724
Loa Loa (eye worm) TK/ABL protein kinase 0.0255 0.4876 0.4855
Brugia malayi Immunoglobulin I-set domain containing protein 0.0038 0.0068 0.0028
Entamoeba histolytica p21-activated kinase 0.0218 0.4054 1
Brugia malayi Protein kinase domain containing protein 0.0043 0.0169 0.013
Echinococcus granulosus protein kinase 0.0131 0.2135 0.2315
Echinococcus granulosus neuroglian 0.0038 0.0068 0.0031
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0214 0.3976 0.4855
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0494 0.1147
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0103 0.1513 1
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0103 0.1513 0.2246
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0061 0.0581 0.2042
Onchocerca volvulus 0.0158 0.2723 0.381
Schistosoma mansoni nck2/grb4 0.0037 0.004 0.0059
Schistosoma mansoni protein kinase 0.0082 0.1037 0.1539
Echinococcus multilocularis roundabout 2 0.0084 0.1077 0.1279
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.007 0.0777 1
Brugia malayi protein kinase C II. 0.0041 0.0137 0.0097
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0237 0.4488 0.4466
Onchocerca volvulus 0.007 0.0784 0.1039
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0098 0.1395 0.9649
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0222 0.4141 0.5059
Schistosoma mansoni tyrosine kinase 0.0237 0.4487 0.6661
Echinococcus granulosus tyrosine protein kinase Src42A 0.0086 0.1125 0.1199
Schistosoma mansoni serine/threonine protein kinase 0.0158 0.2723 0.4042
Brugia malayi Tyrosine-protein kinase abl-1 0.0137 0.2259 0.2228
Brugia malayi hypothetical protein 0.0202 0.3702 0.3677
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0086 0.1125 0.1338
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.007 0.0777 0.3556
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0214 0.3976 0.4349
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.3791 0.9529
Echinococcus granulosus insulin receptor 0.0152 0.2606 0.2836
Schistosoma mansoni protein kinase 0.0234 0.4425 0.6569
Echinococcus granulosus roundabout 2 0.0038 0.0068 0.0031
Brugia malayi C1-like domain containing protein 0.0079 0.0969 0.0933
Brugia malayi Serine/threonine-protein kinase SULU 0.0202 0.3702 0.3677
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0494 0.1147
Onchocerca volvulus 0.0149 0.2538 0.3546
Schistosoma mansoni tyrosine kinase 0.0079 0.0978 0.1451
Giardia lamblia Kinase, CMGC GSK 0.0057 0.0494 0.0485
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0086 0.1125 0.1338
Onchocerca volvulus 0.0043 0.0169 0.016
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0049 0.0316 0.1861
Schistosoma mansoni serine/threonine protein kinase 0.0119 0.1873 0.278
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0119 0.1873 0.2261
Trypanosoma cruzi aurora B kinase, putative 0.0066 0.0685 0.2842
Schistosoma mansoni tyrosine kinase 0.0261 0.5014 0.7443
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.01 0.1434 0.946
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.007 0.0777 0.3556
Loa Loa (eye worm) AUR protein kinase 0.0066 0.0685 0.0647
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0041 0.0137 0.0097
Echinococcus granulosus dual specificity protein kinase clk2 0.007 0.0777 0.0815
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0086 0.1125 0.1199
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0057 0.0494 0.056
Brugia malayi serine/threonine protein kinase 6 0.0066 0.0685 0.0647
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0214 0.3976 0.4349
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0073 0.0834 0.0878
Plasmodium vivax glycogen synthase kinase 3, putative 0.0057 0.0494 0.3852
Loa Loa (eye worm) hypothetical protein 0.0062 0.0592 0.0554
Brugia malayi Protein kinase domain 0.0214 0.3976 0.3951
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0049 0.0316 0.0341
Echinococcus granulosus serine:threonine protein kinase N2 0.0133 0.2165 0.2348
Schistosoma mansoni serine/threonine protein kinase 0.0202 0.3702 0.5495
Loa Loa (eye worm) hypothetical protein 0.0063 0.0612 0.0574
Onchocerca volvulus 0.0043 0.0169 0.016
Echinococcus granulosus tyrosine protein kinase Srms 0.0043 0.0169 0.0143
Echinococcus granulosus activin receptor type 0.0402 0.8146 0.8957
Entamoeba histolytica protein kinase domain containing protein 0.0057 0.0494 0.1125
Loa Loa (eye worm) AUR protein kinase 0.0066 0.0685 0.0647
Schistosoma mansoni nephrin 0.0038 0.0068 0.0101
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0045 0.0231 0.0236
Entamoeba histolytica hypothetical protein 0.0106 0.1586 0.3848
Echinococcus multilocularis tyrosine protein kinase shark 0.0261 0.5014 0.6136
Schistosoma mansoni tyrosine kinase 0.0152 0.2606 0.3869
Trichomonas vaginalis STE family protein kinase 0.0061 0.0581 0.1369
Loa Loa (eye worm) TK/FER protein kinase 0.0043 0.0169 0.013
Schistosoma mansoni tyrosine kinase 0.006 0.0558 0.0828
Echinococcus granulosus tyrosine protein kinase Fyn 0.0086 0.1125 0.1199
Loa Loa (eye worm) hypothetical protein 0.0075 0.0885 0.0849
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0202 0.3702 0.4047
Entamoeba histolytica protein kinase, putative 0.0049 0.0308 0.0661
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0192 0.3486 0.3808
Echinococcus granulosus Vam6:Vps39 protein 0.0103 0.1513 0.1628
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0054 0.0415 0.0463
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0041 0.0137 0.012
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0222 0.4141 0.4532
Entamoeba histolytica protein kinase, putative 0.0214 0.3976 0.9805
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0066 0.0685 0.1601
Schistosoma mansoni protein kinase 0.0106 0.1586 0.2354
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0071 0.0797 0.076
Echinococcus granulosus c src tyrosine kinase 0.0056 0.0459 0.0464
Brugia malayi Furin-like cysteine rich region family protein 0.0079 0.0978 0.0941
Echinococcus granulosus epidermal growth factor receptor 0.0079 0.0978 0.1036
Loa Loa (eye worm) TK/FER protein kinase 0.0043 0.0169 0.013
Entamoeba histolytica protein kinase domain containing protein 0.01 0.1434 0.3468
Onchocerca volvulus 0.0319 0.6309 0.8935
Loa Loa (eye worm) thyroid receptor interactor 0.0086 0.1142 0.1107
Schistosoma mansoni protein kinase C mu 0.0079 0.0969 0.1439
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0214 0.3976 0.4855
Loa Loa (eye worm) hypothetical protein 0.006 0.056 0.0522
Brugia malayi Immunoglobulin I-set domain containing protein 0.0054 0.0423 0.0384
Brugia malayi hypothetical protein 0.0103 0.1513 0.1479
Echinococcus granulosus serine:threonine protein kinase PAK 1 0.0099 0.1427 0.1533
Echinococcus multilocularis epidermal growth factor receptor 0.0079 0.0978 0.1157
Leishmania major protein kinase, putative 0.0061 0.0581 0.2368
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0379 0.7637 0.9371
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.01 0.1434 1
Echinococcus granulosus TGF beta receptor type 1 0.0082 0.1037 0.1101
Schistosoma mansoni serine/threonine protein kinase 0.0108 0.1612 0.2393
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0398 0.8065 0.8058
Loa Loa (eye worm) hypothetical protein 0.0046 0.0233 0.0194
Loa Loa (eye worm) TK/INSR protein kinase 0.0152 0.2606 0.2577
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0066 0.0685 0.0712
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0685 0.1016
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0061 0.0581 0.2042
Schistosoma mansoni nephrin 0.0069 0.0748 0.111
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0103 0.1513 0.9235
Schistosoma mansoni hypothetical protein 0.0106 0.1586 0.2354
Schistosoma mansoni protein kinase 0.0214 0.3976 0.5901
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0108 0.1612 0.1579
Brugia malayi Immunoglobulin I-set domain containing protein 0.0398 0.8065 0.8058
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0079 0.0969 0.0933
Loa Loa (eye worm) hypothetical protein 0.01 0.1442 0.1408
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0119 0.1871 0.2023
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0685 0.1632
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0061 0.0581 0.1342
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0079 0.0969 0.0933
Echinococcus granulosus protein tyrosine kinase 0.0278 0.5385 0.5906
Loa Loa (eye worm) hypothetical protein 0.0073 0.0852 0.0815
Brugia malayi P21-Rho-binding domain containing protein 0.0106 0.1586 0.1552
Entamoeba histolytica PH domain containing protein kinase, putative 0.0053 0.0394 0.0877
Trichomonas vaginalis STE family protein kinase 0.0214 0.3976 1
Trichomonas vaginalis STE family protein kinase 0.0214 0.3976 1
Schistosoma mansoni tyrosine kinase 0.0079 0.0978 0.1451
Schistosoma mansoni rap gtpase-activating protein 0.0103 0.1513 0.2246
Echinococcus multilocularis dual specificity protein kinase clk2 0.007 0.0777 0.0909
Echinococcus multilocularis insulin receptor 0.0152 0.2606 0.3166
Echinococcus granulosus neuroglian 0.006 0.0557 0.0571
Loa Loa (eye worm) hypothetical protein 0.0226 0.424 0.4217
Loa Loa (eye worm) TK/FER protein kinase 0.0043 0.0169 0.013
Echinococcus granulosus serine:threonine protein kinase N2 0.0166 0.2907 0.3168
Echinococcus multilocularis tyrosine protein kinase Abl 0.0137 0.2259 0.2737
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0038 0.0068 0.0035
Schistosoma mansoni tyrosine kinase 0.0086 0.1125 0.167
Echinococcus granulosus leucine rich repeat serine:threonine protein 0.0068 0.0741 0.0775
Brugia malayi STE20-like kinase MST 0.0237 0.4488 0.4466
Loa Loa (eye worm) hypothetical protein 0.0245 0.4663 0.4642
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0045 0.0231 0.0343
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.007 0.0777 0.3556
Onchocerca volvulus 0.0043 0.0169 0.016
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0379 0.7637 0.8394
Loa Loa (eye worm) hypothetical protein 0.0054 0.0423 0.0384
Trichomonas vaginalis STE family protein kinase 0.0214 0.3976 1
Trichomonas vaginalis STE family protein kinase 0.0115 0.1771 0.4395
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0338 0.6737 0.8261
Schistosoma mansoni hypothetical protein 0.0106 0.1586 0.2354
Schistosoma mansoni tyrosine kinase 0.0086 0.1125 0.167
Loa Loa (eye worm) AGC/AKT protein kinase 0.0037 0.0043 0.0003
Schistosoma mansoni serine/threonine protein kinase 0.013 0.2107 0.3128
Echinococcus multilocularis roundabout 2 0.0038 0.0068 0.0035
Echinococcus multilocularis tyrosine protein kinase Blk 0.0073 0.0834 0.098
Echinococcus granulosus PAK box P21 Rho binding 0.0106 0.1586 0.1709
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0066 0.0685 0.0795
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.007 0.0777 0.4995
Brugia malayi p21/Cdc42/Rac1-activated kinase 0.0108 0.1612 0.1579
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0041 0.0131 0.0113
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0131 0.2135 0.2104
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0049 0.0316 0.0305
Echinococcus granulosus tyrosine kinase 0.0043 0.0169 0.0143
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0202 0.3702 0.3677
Brugia malayi Fes/CIP4 homology domain containing protein 0.0086 0.1142 0.1107
Echinococcus granulosus aurora kinase A 0.0066 0.0685 0.0712
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0056 0.0459 0.0682
Brugia malayi Protein kinase domain containing protein 0.01 0.1434 0.1399
Brugia malayi Fibronectin type III domain containing protein 0.0054 0.0423 0.0384
Brugia malayi hypothetical protein 0.0063 0.0612 0.0575
Brugia malayi Tyrosine-protein kinase abl-1 0.0131 0.213 0.2098
Echinococcus multilocularis epidermal growth factor receptor 0.0079 0.0978 0.1157
Schistosoma mansoni protein kinase 0.0214 0.3976 0.5901
Echinococcus granulosus TGF-beta receptor type-1 0.0082 0.1037 0.1101
Schistosoma mansoni tyrosine kinase 0.0079 0.0978 0.1451
Brugia malayi serine/threonine kinase 12 0.0066 0.0685 0.0647
Schistosoma mansoni protein kinase 0.0338 0.6737 1
Echinococcus multilocularis rho associated protein kinase 0.0158 0.2723 0.331
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0103 0.1513 0.1628
Echinococcus granulosus protein kinase c epsilon type 0.0041 0.0137 0.0107
Echinococcus multilocularis leucine rich repeat serine:threonine protein 0.0068 0.0732 0.0854
Echinococcus multilocularis protein tyrosine kinase 0.0278 0.5385 0.6594
Schistosoma mansoni tyrosine kinase 0.0179 0.3196 0.4744
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0086 0.1125 0.1338
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0071 0.0797 0.076
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0222 0.4141 0.5059
Entamoeba histolytica hypothetical protein 0.01 0.1434 0.3468
Brugia malayi Temporarily assigned gene name protein 59 0.0103 0.1513 0.1479
Brugia malayi Protein kinase domain containing protein 0.0043 0.0169 0.013
Loa Loa (eye worm) hypothetical protein 0.0103 0.1513 0.1479
Leishmania major protein kinase, putative 0.0066 0.0685 0.3296
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0103 0.1513 0.1817
Echinococcus granulosus roundabout 2 0.0038 0.0068 0.0031
Schistosoma mansoni serine/threonine protein kinase 0.007 0.0777 0.1153
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0057 0.0494 0.0456
Echinococcus multilocularis serine:threonine protein kinase 3 0.0237 0.4488 0.5487
Schistosoma mansoni protein kinase 0.0131 0.2135 0.3169
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0038 0.0068 0.0035
Loa Loa (eye worm) AGC/PKN protein kinase 0.0166 0.2907 0.2878
Loa Loa (eye worm) TK/FER protein kinase 0.0043 0.0169 0.013
Echinococcus granulosus tyrosine protein kinase Blk 0.0073 0.0834 0.0878
Loa Loa (eye worm) AUR protein kinase 0.0066 0.0685 0.0647
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0043 0.0169 0.0143
Echinococcus granulosus neural Wiskott Aldrich syndrome protein 0.0106 0.1586 0.1709
Echinococcus multilocularis serine:threonine protein kinase N2 0.0166 0.2907 0.3536
Plasmodium falciparum serine/threonine protein kinase, putative 0.0066 0.0685 0.7992
Schistosoma mansoni serine/threonine protein kinase 0.0119 0.1871 0.2777
Loa Loa (eye worm) hypothetical protein 0.0063 0.0612 0.0575
Schistosoma mansoni growth factor receptor-bound protein 0.0037 0.004 0.0059
Schistosoma mansoni tyrosine kinase 0.0231 0.4349 0.6455
Plasmodium falciparum protein serine/threonine kinase-1 0.007 0.0777 1
Echinococcus granulosus rho-associated protein kinase 1 0.0158 0.2723 0.2965
Echinococcus granulosus hypothetical protein 0.0062 0.0592 0.061
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0038 0.0068 0.0035
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.01 0.1434 0.1399
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.01 0.1434 0.8623
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0137 0.0203
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0214 0.3976 0.4349
Echinococcus multilocularis aurora kinase A 0.0066 0.0685 0.0795
Schistosoma mansoni tyrosine kinase 0.0125 0.2006 0.2977
Echinococcus multilocularis dual specificity 0.01 0.1434 0.1719
Echinococcus granulosus serine:threonine protein kinase 3 0.0237 0.4488 0.4915
Schistosoma mansoni tyrosine kinase 0.0152 0.2606 0.3869
Brugia malayi probable protein kinase 0.0234 0.4425 0.4403
Echinococcus granulosus tyrosine protein kinase 0.0264 0.5083 0.5572
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.007 0.0777 0.3556
Entamoeba histolytica protein kinase , putative 0.0066 0.0685 0.1601
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0041 0.0131 0.0101
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0049 0.0316 0.0341
Echinococcus multilocularis serine:threonine protein kinase N2 0.0133 0.2165 0.2621
Schistosoma mansoni tyrosine kinase 0.0278 0.5385 0.7993
Loa Loa (eye worm) TK/FER protein kinase 0.0043 0.0169 0.013
Brugia malayi Protein kinase domain containing protein 0.0473 0.9721 0.972
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0073 0.0834 0.098
Trichomonas vaginalis mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative 0.0108 0.1612 0.3991
Loa Loa (eye worm) TK/FER protein kinase 0.0043 0.0169 0.013
Echinococcus multilocularis activin receptor type 0.0402 0.8146 1
Trypanosoma brucei aurora B kinase 0.0066 0.0685 0.4366
Echinococcus multilocularis tyrosine kinase 0.0043 0.0169 0.0159
Brugia malayi WH1 domain containing protein 0.0106 0.1586 0.1552
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.007 0.0777 0.4995
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0094 0.1316 0.1282
Echinococcus multilocularis TGF beta receptor type 1 0.0082 0.1037 0.123
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0086 0.1125 0.1199
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0043 0.0169 0.0316
Echinococcus multilocularis tyrosine protein kinase 0.0264 0.5083 0.6221
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0338 0.6737 0.74
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0086 0.1125 0.1338
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0119 0.1871 0.2258
Echinococcus multilocularis protein kinase shaggy 0.0057 0.0494 0.056
Onchocerca volvulus 0.0043 0.0169 0.016
Giardia lamblia Kinase, STE STE20 0.0214 0.3976 1
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0066 0.0685 0.7992
Schistosoma mansoni hypothetical protein 0.0103 0.1513 0.2246
Loa Loa (eye worm) TK/EGFR protein kinase 0.0079 0.0978 0.0941
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0057 0.0494 0.0456
Echinococcus granulosus protein kinase c iota type 0.0041 0.0137 0.0107
Schistosoma mansoni tyrosine kinase 0.0048 0.0296 0.044
Giardia lamblia Kinase, CMGC CLK 0.007 0.0777 0.1259
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0161 0.2798 0.3047
Brugia malayi SH2 domain containing protein 0.0043 0.0169 0.013
Echinococcus multilocularis 0.0062 0.0592 0.0681
Loa Loa (eye worm) hypothetical protein 0.0213 0.3947 0.3922
Brugia malayi Immunoglobulin I-set domain containing protein 0.0038 0.0068 0.0028
Echinococcus granulosus tyrosine protein kinase shark 0.0261 0.5014 0.5496
Loa Loa (eye worm) hypothetical protein 0.0103 0.1513 0.1479
Loa Loa (eye worm) TK protein kinase 0.0073 0.0834 0.0798
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0057 0.0494 0.0733
Loa Loa (eye worm) hypothetical protein 0.0054 0.0423 0.0384
Echinococcus granulosus tyrosine protein kinase Lyn 0.0094 0.131 0.1403
Echinococcus multilocularis neuroglian 0.0038 0.0068 0.0035
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0137 0.0203
Schistosoma mansoni protein kinase 0.0092 0.1271 0.1887
Echinococcus multilocularis c src tyrosine kinase 0.0056 0.0459 0.0518
Brugia malayi Protein kinase domain containing protein 0.0281 0.5453 0.5435
Giardia lamblia Kinase, AGC AKT 0.0094 0.1316 0.2733
Schistosoma mansoni tyrosine kinase 0.0222 0.4141 0.6147
Schistosoma mansoni serine/threonine protein kinase 0.0119 0.1871 0.2777
Schistosoma mansoni protein kinase 0.0066 0.0685 0.1016
Echinococcus granulosus tyrosine protein kinase Fyn 0.0086 0.1125 0.1199
Loa Loa (eye worm) TK/FER protein kinase 0.0043 0.0169 0.013
Entamoeba histolytica protein kinase domain containing protein 0.0066 0.0685 0.1601
Brugia malayi SH2 domain containing protein 0.0043 0.0169 0.013
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0038 0.0068 0.0035
Loa Loa (eye worm) AGC/PKA protein kinase 0.0049 0.0316 0.0277
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0057 0.0494 0.137
Schistosoma mansoni atypical protein kinase C 0.0041 0.0137 0.0203
Schistosoma mansoni protein kinase 0.0115 0.1771 0.2629
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0086 0.1125 0.1338
Entamoeba histolytica protein kinase, putative 0.0057 0.0494 0.1125
Brugia malayi Protein kinase domain containing protein 0.0152 0.2606 0.2577
Loa Loa (eye worm) hypothetical protein 0.0103 0.1513 0.1479
Loa Loa (eye worm) hypothetical protein 0.0075 0.0885 0.0849
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0049 0.0316 0.0305
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0061 0.0581 0.3661
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0255 0.4876 0.5965
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0079 0.0978 0.1036
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0049 0.0316 0.1861
Plasmodium falciparum glycogen synthase kinase 3 0.0057 0.0494 0.3852
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0046 0.0253 0.0214
Echinococcus granulosus twitchin 0.0068 0.0742 0.0775
Schistosoma mansoni cell adhesion molecule 0.0038 0.0068 0.0101
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0057 0.0494 0.0502
Loa Loa (eye worm) SRC-1 0.0086 0.1125 0.1089
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0066 0.0685 0.1601
Loa Loa (eye worm) TK/ALK protein kinase 0.0261 0.5009 0.4989
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0119 0.1873 0.2026
Brugia malayi Protein kinase domain containing protein 0.0037 0.0043 0.0003
Echinococcus granulosus contactin 0.0038 0.0068 0.0031
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0086 0.1125 0.1338
Loa Loa (eye worm) hypothetical protein 0.0045 0.0231 0.0192
Schistosoma mansoni tyrosine kinase 0.0056 0.0459 0.0682
Echinococcus multilocularis protein kinase c epsilon type 0.0041 0.0137 0.012
Brugia malayi protein-tyrosine kinase 0.0073 0.0834 0.0798
Brugia malayi Protein kinase domain containing protein 0.0071 0.0797 0.076
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0092 0.1271 0.1236
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0066 0.0685 0.1601
Leishmania major protein kinase, putative 0.007 0.0777 0.4123
Plasmodium vivax serine/threonine kinase-1, putative 0.007 0.0777 1
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0226 0.424 0.4641
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0685 0.1632
Toxoplasma gondii aurora kinase 0.0066 0.0685 0.7992
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0049 0.0316 0.0341
Echinococcus multilocularis tyrosine protein kinase Srms 0.0073 0.0834 0.098
Loa Loa (eye worm) hypothetical protein 0.0091 0.1249 0.1214
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0038 0.0068 0.0101
Leishmania major protein kinase, putative 0.007 0.0777 0.4123
Schistosoma mansoni neuroglian 0.0038 0.0068 0.0101
Entamoeba histolytica PH domain containing protein kinase, putative 0.0053 0.0394 0.0877
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0685 0.1632
Echinococcus multilocularis 0.0131 0.2135 0.2585
Loa Loa (eye worm) hypothetical protein 0.0206 0.3791 0.3766
Onchocerca volvulus 0.0043 0.0169 0.016
Echinococcus granulosus Immunoglobulin 0.0045 0.0231 0.0211
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.013 0.2107 0.2285
Loa Loa (eye worm) hypothetical protein 0.0091 0.1249 0.1214
Schistosoma mansoni serine/threonine protein kinase 0.0235 0.4447 0.66
Schistosoma mansoni serine/threonine protein kinase 0.0108 0.1612 0.2393
Onchocerca volvulus 0.0063 0.0612 0.0793
Giardia lamblia Kinase, STE STE20 0.0061 0.0581 0.0723
Brugia malayi Protein kinase domain containing protein 0.0043 0.0169 0.013
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0316 0.047
Echinococcus granulosus 3'partial|serine:threonine protein kinase PAK 2 0.0106 0.1586 0.1709
Schistosoma mansoni serine/threonine protein kinase 0.0138 0.2296 0.3408
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.006 0.056 0.0575
Echinococcus granulosus protein kinase shaggy 0.0057 0.0494 0.0502
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0444 0.909 1
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0061 0.0581 0.1342
Brugia malayi Protein kinase domain containing protein 0.0043 0.0169 0.013
Brugia malayi intracellular kinase 0.0057 0.0494 0.0456
Loa Loa (eye worm) hypothetical protein 0.0049 0.0316 0.0277
Entamoeba histolytica protein kinase, putative 0.0066 0.0685 0.1601
Loa Loa (eye worm) TK/FER protein kinase 0.0043 0.0169 0.013
Echinococcus granulosus tyrosine protein kinase ABL1 0.0255 0.4876 0.5343
Echinococcus granulosus tyrosine kinase 0.0073 0.0834 0.0878
Schistosoma mansoni tyrosine kinase 0.006 0.0558 0.0828
Giardia lamblia Kinase, CMGC GSK 0.0057 0.0494 0.0485
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0045 0.0231 0.0343
Schistosoma mansoni serine/threonine protein kinase 0.0166 0.2907 0.4315
Entamoeba histolytica protein kinase domain containing protein 0.0057 0.0494 0.1125
Loa Loa (eye worm) hypothetical protein 0.0045 0.0231 0.0192
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0086 0.1125 0.1338
Trichomonas vaginalis STE family protein kinase 0.0214 0.3976 1
Echinococcus granulosus tyrosine protein kinase HCK 0.0049 0.0308 0.0296
Loa Loa (eye worm) P21-Rho-binding domain-containing protein 0.0106 0.1586 0.1552
Brugia malayi hypothetical protein 0.0054 0.0423 0.0384
Echinococcus multilocularis tyrosine protein kinase HCK 0.0049 0.0308 0.033
Trypanosoma cruzi p21-activated kinase 3, putative 0.0108 0.1612 1
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0316 0.047
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0049 0.0316 0.0277
Entamoeba histolytica protein kinase, putative 0.0066 0.0685 0.1601
Trypanosoma brucei protein kinase, putative 0.0057 0.0494 0.3068
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0057 0.0494 0.3852
Brugia malayi protein C17H12.11 0.0063 0.0612 0.0575
Brugia malayi Protein kinase domain containing protein 0.0264 0.5083 0.5063
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0086 0.1125 0.1338
Loa Loa (eye worm) hypothetical protein 0.0043 0.0169 0.013
Echinococcus multilocularis PAK box P21 Rho binding 0.0106 0.1586 0.1907
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0057 0.0494 0.1588
Loa Loa (eye worm) hypothetical protein 0.007 0.0784 0.0747
Loa Loa (eye worm) TK protein kinase 0.0264 0.5083 0.5063
Onchocerca volvulus 0.0074 0.0862 0.1151
Entamoeba histolytica protein kinase, putative 0.0118 0.1849 0.4504
Schistosoma mansoni serine/threonine protein kinase 0.007 0.0777 0.1153
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0316 0.047
Loa Loa (eye worm) TK/FER protein kinase 0.0043 0.0169 0.013
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0161 0.2798 0.3402
Onchocerca volvulus Tyrosine kinase homolog 0.0353 0.7053 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0423 0.0384
Echinococcus granulosus fibroblast growth factor receptor 4 0.0222 0.4141 0.4532
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.013 0.2107 0.255
Brugia malayi Immunoglobulin I-set domain containing protein 0.0236 0.4467 0.4444
Onchocerca volvulus 0.0057 0.0494 0.0624
Brugia malayi Protein kinase domain containing protein 0.0338 0.6737 0.6724
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0108 0.1612 1
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0111 0.1698 0.1832
Echinococcus multilocularis serine:threonine protein kinase receptor R3 0.0082 0.1037 0.123
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0137 0.0203
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.013 0.2107 0.2076
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0192 0.3486 0.4251
Echinococcus granulosus Protein kinase C brain isozyme 0.0041 0.0137 0.0107
Loa Loa (eye worm) TK protein kinase 0.0049 0.0308 0.0269
Loa Loa (eye worm) TK/FER protein kinase 0.0043 0.0169 0.013
Onchocerca volvulus 0.0043 0.0169 0.016
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0037 0.004 0.0059
Giardia lamblia Aurora kinase 0.0066 0.0685 0.1006
Brugia malayi Immunoglobulin I-set domain containing protein 0.0038 0.0068 0.0028
Entamoeba histolytica protein kinase, putative 0.01 0.1434 0.3468
Entamoeba histolytica protein kinase, putative 0.01 0.1434 0.3468
Schistosoma mansoni adapter molecule crk 0.0037 0.004 0.0059
Echinococcus multilocularis Immunoglobulin 0.0045 0.0231 0.0236
Echinococcus granulosus tyrosine protein kinase Src42A 0.0054 0.0415 0.0414
Brugia malayi Protein kinase domain containing protein 0.0092 0.1271 0.1236
Schistosoma mansoni serine/threonine protein kinase 0.01 0.1434 0.2128
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0038 0.0068 0.0028
Loa Loa (eye worm) CMGC/CLK protein kinase 0.007 0.0777 0.074
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0043 0.0169 0.0159
Loa Loa (eye worm) hypothetical protein 0.0063 0.0612 0.0574
Loa Loa (eye worm) TKL/LRRK protein kinase 0.0068 0.0732 0.0695
Schistosoma mansoni hypothetical protein 0.0106 0.1586 0.2354
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0103 0.1513 0.2246
Onchocerca volvulus 0.0103 0.1513 0.2081
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0119 0.1873 0.1841

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.203 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.