Detailed information for compound 1595720

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 403.47 | Formula: C25H25NO4
  • H donors: 2 H acceptors: 3 LogP: 5.62 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cccc(c1)C(=O)O)COc1ccc(cc1)c1ccc(cc1)C(C)(C)C
  • InChi: 1S/C25H25NO4/c1-25(2,3)20-11-7-17(8-12-20)18-9-13-22(14-10-18)30-16-23(27)26-21-6-4-5-19(15-21)24(28)29/h4-15H,16H2,1-3H3,(H,26,27)(H,28,29)
  • InChiKey: QXBOQILKUMBONF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0073 0.0601 0.1151
Schistosoma mansoni serine/threonine protein kinase 0.0118 0.1287 0.2814
Loa Loa (eye worm) hypothetical protein 0.0053 0.0304 0.0304
Loa Loa (eye worm) hypothetical protein 0.0224 0.2881 0.2881
Schistosoma mansoni tyrosine kinase 0.0275 0.3654 0.7992
Echinococcus granulosus epidermal growth factor receptor 0.0078 0.0678 0.0835
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.013 0.1465 0.1465
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0486 0.1626
Trichomonas vaginalis STE family protein kinase 0.0061 0.0416 0.1392
Schistosoma mansoni vav2 0.0035 0.0018 0.004
Echinococcus granulosus activin receptor type 0.0398 0.5524 0.6797
Loa Loa (eye worm) TK/EGFR protein kinase 0.0078 0.0678 0.0678
Entamoeba histolytica protein kinase, putative 0.0099 0.0992 0.3261
Trichomonas vaginalis STE family protein kinase 0.0231 0.2989 1
Echinococcus granulosus 3'partial|serine:threonine protein kinase PAK 2 0.0124 0.1367 0.1682
Trypanosoma cruzi p21-activated kinase 3, putative 0.0107 0.1115 1
Echinococcus granulosus leucine rich repeat serine:threonine protein 0.0068 0.0524 0.0645
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0102 0.104 0.128
Entamoeba histolytica protein kinase , putative 0.0066 0.0486 0.1598
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0061 0.0416 0.2035
Trypanosoma cruzi aurora B kinase, putative 0.0066 0.0486 0.2832
Schistosoma mansoni wiskott-aldrich syndrome protein 0.0124 0.1367 0.299
Echinococcus multilocularis activin receptor type 0.0398 0.5524 0.6797
Entamoeba histolytica protein kinase, putative 0.0048 0.0226 0.0744
Schistosoma mansoni tyrosine kinase 0.0151 0.1778 0.3889
Echinococcus multilocularis dual specificity 0.0099 0.0992 0.1221
Brugia malayi Immunoglobulin I-set domain containing protein 0.0394 0.5463 0.5463
Echinococcus multilocularis serine:threonine protein kinase receptor R3 0.0081 0.0724 0.0891
Entamoeba histolytica protein kinase, putative 0.0037 0.0053 0.0173
Brugia malayi hypothetical protein 0.0053 0.0304 0.0304
Echinococcus granulosus serine:threonine protein kinase PAK 1 0.0098 0.0985 0.1212
Leishmania major protein kinase, putative 0.0061 0.0416 0.2368
Schistosoma mansoni vam6/vps39 related 0.0102 0.104 0.2275
Echinococcus multilocularis epidermal growth factor receptor 0.0078 0.0678 0.0835
Schistosoma mansoni tyrosine kinase 0.006 0.0395 0.0864
Brugia malayi Furin-like cysteine rich region family protein 0.0078 0.0678 0.0678
Trichomonas vaginalis STE family protein kinase 0.0231 0.2989 1
Onchocerca volvulus 0.0316 0.4277 0.8935
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0085 0.0778 0.0957
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0078 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0042 0.0133 0.0133
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0099 0.0992 0.0992
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0055 0.0329 0.0719
Schistosoma mansoni tyrosine kinase 0.0078 0.0678 0.1484
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0071 0.0562 0.0562
Schistosoma mansoni serine/threonine protein kinase 0.0118 0.1289 0.2818
Trichomonas vaginalis AGC family protein kinase 0.0037 0.0053 0.0176
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0486 0.1626
Trichomonas vaginalis conserved hypothetical protein 0.0222 0.2858 0.9564
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0116 0.0255
Loa Loa (eye worm) hypothetical protein 0.0102 0.104 0.104
Entamoeba histolytica PH domain containing protein kinase, putative 0.0053 0.029 0.0954
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0231 0.2989 0.3678
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.019 0.2372 0.2919
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0049 0.0237 0.0292
Loa Loa (eye worm) hypothetical protein 0.0074 0.0616 0.0616
Schistosoma mansoni serine/threonine protein kinase 0.02 0.2523 0.5519
Echinococcus granulosus tyrosine protein kinase Fyn 0.0085 0.0778 0.0957
Echinococcus granulosus insulin receptor 0.0151 0.1778 0.2188
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0061 0.0416 0.1368
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0042 0.0133 0.0436
Echinococcus multilocularis neuroglian 0.0059 0.0394 0.0485
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0111 0.117 0.144
Brugia malayi Protein kinase domain containing protein 0.0258 0.3401 0.3401
Schistosoma mansoni vesicular amine transporter 0.0045 0.0175 0.0382
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0057 0.0357 0.0357
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.044 0.6155 0.7574
Plasmodium falciparum serine/threonine protein kinase, putative 0.0066 0.0486 0.7992
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0116 0.0255
Entamoeba histolytica protein kinase, putative 0.0136 0.155 0.5097
Loa Loa (eye worm) AGC/PKA protein kinase 0.0049 0.0237 0.0237
Brugia malayi Serine/threonine-protein kinase SULU 0.02 0.2523 0.2523
Brugia malayi Protein kinase domain containing protein 0.0042 0.0133 0.0133
Echinococcus granulosus tyrosine protein kinase Srms 0.0042 0.0133 0.0163
Brugia malayi protein C17H12.11 0.0062 0.0432 0.0432
Echinococcus granulosus hypothetical protein 0.0061 0.0418 0.0515
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0231 0.2989 0.3678
Entamoeba histolytica hypothetical protein 0.0099 0.0992 0.3261
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0231 0.2989 0.3678
Loa Loa (eye worm) TKL/STKR/TYPE2 protein kinase 0.0071 0.0562 0.0562
Echinococcus multilocularis protein tyrosine kinase 0.0275 0.3654 0.4496
Brugia malayi SRC-1 0.0085 0.0778 0.0778
Schistosoma mansoni tyrosine kinase 0.0177 0.2176 0.4759
Echinococcus granulosus protein kinase c epsilon type 0.0041 0.0116 0.0143
Loa Loa (eye worm) TKL/LRRK protein kinase 0.0068 0.0518 0.0518
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0102 0.104 0.2275
Echinococcus multilocularis rho associated protein kinase 0.0156 0.1862 0.2291
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0335 0.4572 0.5626
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0066 0.0486 0.1598
Echinococcus granulosus epidermal growth factor receptor 0.0078 0.0678 0.0835
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0219 0.2814 0.3463
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0078 0.0678 0.0835
Echinococcus granulosus TGF beta receptor type 1 0.0081 0.0724 0.0891
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0099 0.0992 1
Schistosoma mansoni protein kinase 0.0132 0.1498 0.3275
Onchocerca volvulus 0.0062 0.0432 0.0793
Entamoeba histolytica PH domain containing protein kinase, putative 0.0053 0.029 0.0954
Echinococcus granulosus c src tyrosine kinase 0.0055 0.0329 0.0404
Brugia malayi hypothetical protein 0.02 0.2523 0.2523
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0085 0.0778 0.0957
Onchocerca volvulus 0.0042 0.0133 0.016
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0036 0.0045 0.0045
Loa Loa (eye worm) AUR protein kinase 0.0066 0.0486 0.0486
Echinococcus granulosus protein kinase c iota type 0.0041 0.0116 0.0143
Entamoeba histolytica protein kinase, putative 0.0132 0.1498 0.4924
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0237 0.0519
Echinococcus multilocularis neural Wiskott Aldrich syndrome protein 0.0124 0.1367 0.1682
Loa Loa (eye worm) hypothetical protein 0.007 0.0548 0.0548
Loa Loa (eye worm) hypothetical protein 0.0036 0.0045 0.0045
Echinococcus multilocularis growth factor receptor bound protein 2 0.0036 0.0045 0.0056
Echinococcus multilocularis aurora kinase A 0.0066 0.0486 0.0598
Schistosoma mansoni serine/threonine protein kinase 0.0107 0.1115 0.244
Echinococcus multilocularis tyrosine protein kinase Srms 0.0072 0.0582 0.0716
Schistosoma mansoni nephrin 0.0038 0.0065 0.0141
Echinococcus granulosus protein kinase 0.013 0.1465 0.1803
Trichomonas vaginalis AGC family protein kinase 0.0037 0.0053 0.0176
Echinococcus granulosus tyrosine protein kinase Fyn 0.0085 0.0778 0.0957
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0335 0.4572 0.5626
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0036 0.0045 0.0099
Brugia malayi p21/Cdc42/Rac1-activated kinase 0.0107 0.1115 0.1115
Brugia malayi Fibronectin type III domain containing protein 0.0053 0.0304 0.0304
Schistosoma mansoni tyrosine kinase 0.0228 0.2954 0.6462
Brugia malayi P21-Rho-binding domain containing protein 0.0124 0.1367 0.1367
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0394 0.5463 0.5463
Onchocerca volvulus 0.0042 0.0133 0.016
Echinococcus multilocularis NCK adaptor protein 0.0036 0.0045 0.0056
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0046 0.0195 0.0195
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.007 0.0549 0.3543
Loa Loa (eye worm) hypothetical protein 0.0242 0.3167 0.3167
Echinococcus multilocularis leucine rich repeat serine:threonine protein 0.0068 0.0518 0.0638
Schistosoma mansoni tyrosine kinase 0.0235 0.3048 0.6666
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0085 0.0778 0.0957
Trichomonas vaginalis AGC family protein kinase 0.0037 0.0053 0.0176
Entamoeba histolytica protein kinase, putative 0.0136 0.155 0.5097
Echinococcus granulosus neuroglian 0.0038 0.0065 0.0079
Echinococcus multilocularis serine:threonine protein kinase N2 0.0165 0.1986 0.2444
Giardia lamblia Kinase, STE STE20 0.0231 0.2989 1
Schistosoma mansoni hypothetical protein 0.0102 0.104 0.2275
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.007 0.0549 0.5023
Schistosoma mansoni serine/threonine protein kinase 0.0155 0.1846 0.4038
Schistosoma mansoni tyrosine kinase 0.0078 0.0678 0.1484
Echinococcus granulosus neuroglian 0.0059 0.0394 0.0485
Onchocerca volvulus 0.0042 0.0133 0.016
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0231 0.2989 0.3678
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0102 0.104 0.2275
Brugia malayi Immunoglobulin I-set domain containing protein 0.0038 0.0065 0.0065
Onchocerca volvulus 0.0042 0.0133 0.016
Entamoeba histolytica protein kinase, putative 0.0099 0.0992 0.3261
Schistosoma mansoni protein kinase C mu 0.0078 0.0678 0.1484
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0036 0.0045 0.0045
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.057 0.8127 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0418 0.0418
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0237 0.0795
Loa Loa (eye worm) AUR protein kinase 0.0066 0.0486 0.0486
Echinococcus granulosus tyrosine protein kinase Fyn 0.0085 0.0778 0.0957
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0694 1 1
Loa Loa (eye worm) AGC/PKN protein kinase 0.0165 0.1986 0.1986
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.02 0.2523 0.3105
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0118 0.1287 0.1583
Loa Loa (eye worm) TK/FER protein kinase 0.0042 0.0133 0.0133
Schistosoma mansoni nck2/grb4 0.0036 0.0045 0.0099
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0071 0.0562 0.0562
Schistosoma mansoni tyrosine kinase 0.006 0.0395 0.0864
Trichomonas vaginalis CMGC family protein kinase 0.007 0.0549 0.1835
Loa Loa (eye worm) hypothetical protein 0.0073 0.0593 0.0593
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0049 0.0237 0.0237
Echinococcus multilocularis neuroglian 0.0038 0.0065 0.0079
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0111 0.117 0.144
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0102 0.104 0.914
Loa Loa (eye worm) P21-Rho-binding domain-containing protein 0.0124 0.1367 0.1367
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0118 0.1287 0.1583
Brugia malayi Protein kinase domain containing protein 0.0068 0.0518 0.0518
Schistosoma mansoni neuroglian 0.0038 0.0065 0.0141
Toxoplasma gondii AGC kinase 0.0049 0.0237 0.4329
Echinococcus granulosus Immunoglobulin 0.0045 0.0175 0.0215
Loa Loa (eye worm) hypothetical protein 0.0045 0.0175 0.0175
Echinococcus granulosus PAK box P21 Rho binding 0.0124 0.1367 0.1682
Echinococcus granulosus growth factor receptor bound protein 2 0.0036 0.0045 0.0056
Schistosoma mansoni cell adhesion molecule 0.0038 0.0065 0.0141
Brugia malayi Protein kinase domain containing protein 0.0278 0.37 0.37
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0118 0.1289 0.1586
Schistosoma mansoni serine/threonine protein kinase 0.0118 0.1287 0.2814
Schistosoma mansoni protein kinase 0.0091 0.0877 0.1918
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0049 0.0237 0.1872
Echinococcus multilocularis roundabout 2 0.0083 0.0745 0.0917
Schistosoma mansoni ste20-related kinase 0.0183 0.2262 0.4947
Brugia malayi Protein kinase domain containing protein 0.0042 0.0133 0.0133
Entamoeba histolytica protein kinase, putative 0.0231 0.2989 0.9827
Echinococcus granulosus tyrosine protein kinase Src64B 0.0085 0.0778 0.0957
Brugia malayi Immunoglobulin I-set domain containing protein 0.0038 0.0065 0.0065
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.006 0.0397 0.0488
Toxoplasma gondii aurora kinase 0.0066 0.0486 0.8861
Loa Loa (eye worm) TK/ALK protein kinase 0.0258 0.34 0.34
Giardia lamblia Kinase, CMGC GSK 0.0057 0.0357 0.0436
Loa Loa (eye worm) AUR protein kinase 0.0066 0.0486 0.0486
Schistosoma mansoni tyrosine kinase 0.0219 0.2814 0.6155
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0072 0.0582 0.0716
Brugia malayi Variant SH3 domain containing protein 0.0036 0.0045 0.0045
Echinococcus granulosus Protein kinase C brain isozyme 0.0041 0.0116 0.0143
Loa Loa (eye worm) SRC-1 0.0085 0.0778 0.0778
Leishmania major protein kinase, putative 0.007 0.0549 0.4123
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0357 0.1195
Echinococcus granulosus dual specificity 0.0099 0.0992 0.1221
Echinococcus multilocularis tyrosine protein kinase shark 0.0258 0.3404 0.4188
Plasmodium falciparum protein serine/threonine kinase-1 0.007 0.0549 1
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0066 0.0486 0.0598
Brugia malayi SH2 domain containing protein 0.0042 0.0133 0.0133
Entamoeba histolytica hypothetical protein 0.0124 0.1367 0.4495
Giardia lamblia Aurora kinase 0.0066 0.0486 0.0904
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0049 0.0237 0.0292
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0129 0.1447 0.1447
Onchocerca volvulus 0.0057 0.0357 0.0636
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0085 0.0778 0.0957
Brugia malayi Protein kinase domain containing protein 0.0151 0.1778 0.1778
Echinococcus multilocularis epidermal growth factor receptor 0.0078 0.0678 0.0835
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0057 0.0357 0.1365
Echinococcus granulosus roundabout 2 0.0038 0.0065 0.0079
Echinococcus granulosus serine:threonine protein kinase TAO1 0.02 0.2523 0.3105
Schistosoma mansoni tyrosine kinase 0.0078 0.0678 0.1484
Loa Loa (eye worm) TK/INSR protein kinase 0.0151 0.1778 0.1778
Loa Loa (eye worm) hypothetical protein 0.0211 0.2683 0.2683
Schistosoma mansoni serine/threonine protein kinase 0.0233 0.3026 0.6618
Echinococcus granulosus tyrosine protein kinase Src42A 0.0085 0.0778 0.0957
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0224 0.2881 0.3545
Echinococcus granulosus dual specificity protein kinase clk2 0.007 0.0549 0.0675
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.02 0.2523 0.2523
Schistosoma mansoni tyrosine kinase 0.0142 0.165 0.361
Brugia malayi Fes/CIP4 homology domain containing protein 0.0086 0.0789 0.0789
Echinococcus granulosus rho-associated protein kinase 1 0.0156 0.1862 0.2291
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0235 0.3054 0.3054
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0097 0.0965 0.9649
Echinococcus granulosus serine:threonine protein kinase 3 0.0235 0.3054 0.3758
Schistosoma mansoni serine/threonine protein kinase 0.007 0.0549 0.12
Brugia malayi Protein kinase domain 0.0231 0.2989 0.2989
Echinococcus multilocularis protein kinase c iota type 0.0041 0.0116 0.0143
Onchocerca volvulus 0.007 0.0548 0.1039
Echinococcus multilocularis TGF beta receptor type 1 0.0081 0.0724 0.0891
Echinococcus granulosus roundabout 2 0.0083 0.0745 0.0917
Echinococcus multilocularis myosin iiia 0.0061 0.0416 0.0512
Echinococcus granulosus contactin 0.0038 0.0065 0.0079
Onchocerca volvulus 0.0156 0.1862 0.3822
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0102 0.104 0.128
Onchocerca volvulus 0.0102 0.104 0.2081
Plasmodium vivax glycogen synthase kinase 3, putative 0.0057 0.0357 0.3852
Loa Loa (eye worm) TK/FER protein kinase 0.0042 0.0133 0.0133
Brugia malayi Tyrosine-protein kinase abl-1 0.0135 0.1544 0.1544
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.004 0.0107 0.0132
Schistosoma mansoni growth factor receptor-bound protein 0.0036 0.0045 0.0099
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0219 0.2814 0.3463
Schistosoma mansoni adapter molecule crk 0.0036 0.0045 0.0099
Trichomonas vaginalis STE family protein kinase 0.0231 0.2989 1
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0038 0.0065 0.0065
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0335 0.4572 0.4572
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0252 0.331 0.4073
Echinococcus granulosus defective proboscis extension response 0.0045 0.0175 0.0215
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0099 0.0992 0.9513
Echinococcus granulosus NCK adaptor protein 0.0036 0.0045 0.0056
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0085 0.0778 0.0957
Schistosoma mansoni hypothetical protein 0.0124 0.1367 0.299
Schistosoma mansoni hypothetical protein 0.0124 0.1367 0.299
Echinococcus granulosus twitchin 0.0068 0.0525 0.0646
Leishmania major protein kinase, putative 0.007 0.0549 0.4123
Loa Loa (eye worm) thyroid receptor interactor 0.0086 0.0789 0.0789
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0049 0.0237 0.0292
Echinococcus multilocularis c src tyrosine kinase 0.0055 0.0329 0.0404
Loa Loa (eye worm) TK protein kinase 0.0234 0.3034 0.3034
Schistosoma mansoni protein kinase 0.013 0.1465 0.3205
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0072 0.0582 0.0716
Echinococcus granulosus tyrosine protein kinase ABL1 0.0252 0.331 0.4073
Loa Loa (eye worm) TK/FER protein kinase 0.0042 0.0133 0.0133
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0066 0.0486 0.1598
Schistosoma mansoni growth factor receptor-bound protein 0.0036 0.0045 0.0099
Brugia malayi Variant SH3 domain containing protein 0.0036 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0049 0.0237 0.0237
Echinococcus granulosus protein kinase shaggy 0.0057 0.0357 0.044
Loa Loa (eye worm) hypothetical protein 0.0045 0.0176 0.0176
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0061 0.0416 0.3681
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0468 0.6587 0.6587
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0057 0.0357 0.0357
Schistosoma mansoni tyrosine kinase 0.006 0.0395 0.0864
Onchocerca volvulus 0.0148 0.1732 0.3546
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0049 0.0237 0.0292
Brugia malayi Protein kinase domain containing protein 0.0042 0.0133 0.0133
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0107 0.1115 1
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0061 0.0416 0.1368
Loa Loa (eye worm) hypothetical protein 0.0062 0.0432 0.0432
Schistosoma mansoni hypothetical protein 0.0124 0.1367 0.299
Brugia malayi Immunoglobulin I-set domain containing protein 0.0234 0.3034 0.3034
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0045 0.0175 0.0215
Echinococcus multilocularis serine:threonine protein kinase N2 0.0131 0.148 0.1821
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0045 0.0175 0.0382
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0219 0.2814 0.3463
Loa Loa (eye worm) hypothetical protein 0.009 0.0861 0.0861
Trypanosoma brucei aurora B kinase 0.0066 0.0486 0.439
Loa Loa (eye worm) hypothetical protein 0.0053 0.0304 0.0304
Echinococcus multilocularis PAK box P21 Rho binding 0.0132 0.1498 0.1843
Brugia malayi Protein kinase domain containing protein 0.007 0.0549 0.0549
Echinococcus multilocularis roundabout 2 0.0038 0.0065 0.0079
Loa Loa (eye worm) hypothetical protein 0.0038 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.009 0.0861 0.0861
Echinococcus granulosus tyrosine kinase 0.0072 0.0582 0.0716
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0231 0.2989 0.3678
Brugia malayi serine/threonine protein kinase 6 0.0066 0.0486 0.0486
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.007 0.0549 0.3543
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0049 0.0237 0.0292
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0486 0.1626
Plasmodium vivax serine/threonine kinase-1, putative 0.007 0.0549 1
Schistosoma mansoni protein kinase 0.0066 0.0486 0.1063
Brugia malayi Protein kinase domain containing protein 0.0071 0.0562 0.0562
Brugia malayi bone morphogenetic protein type 1 receptor 0.0091 0.0877 0.0877
Brugia malayi protein-tyrosine kinase 0.0072 0.0582 0.0582
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0116 0.0255
Schistosoma mansoni tyrosine kinase 0.0055 0.0329 0.0719
Echinococcus multilocularis Immunoglobulin 0.0045 0.0175 0.0215
Trichomonas vaginalis AGC family protein kinase 0.0037 0.0053 0.0176
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0085 0.0778 0.0957
Loa Loa (eye worm) hypothetical protein 0.0102 0.104 0.104
Schistosoma mansoni serine/threonine protein kinase 0.0129 0.1447 0.3164
Schistosoma mansoni nephrin 0.0068 0.0523 0.1145
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0107 0.1115 0.1115
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0102 0.104 1
Brugia malayi hypothetical protein 0.0062 0.0432 0.0432
Loa Loa (eye worm) TK/FER protein kinase 0.0042 0.0133 0.0133
Echinococcus multilocularis roundabout 2 0.0038 0.0065 0.0079
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0091 0.0877 0.0877
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0099 0.0992 0.8592
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.007 0.0549 0.5023
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0038 0.0065 0.0079
Echinococcus multilocularis tyrosine protein kinase HCK 0.0048 0.0226 0.0278
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0053 0.0299 0.0367
Loa Loa (eye worm) hypothetical protein 0.0099 0.0992 0.0992
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0099 0.0992 0.8592
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0038 0.0065 0.0079
Entamoeba histolytica protein kinase, putative 0.0066 0.0486 0.1598
Brugia malayi SH2 domain containing protein 0.0042 0.0133 0.0133
Trichomonas vaginalis AGC family protein kinase 0.0037 0.0053 0.0176
Brugia malayi hypothetical protein 0.0042 0.0133 0.0133
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0049 0.0237 0.1872
Schistosoma mansoni atypical protein kinase C 0.0041 0.0116 0.0255
Echinococcus multilocularis 0.013 0.1465 0.1803
Echinococcus granulosus tyrosine protein kinase Btk29A 0.019 0.2372 0.2919
Echinococcus granulosus TGF-beta receptor type-1 0.0081 0.0724 0.0891
Brugia malayi WH1 domain containing protein 0.0124 0.1367 0.1367
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0041 0.0116 0.0116
Echinococcus multilocularis PAK box P21 Rho binding 0.0124 0.1367 0.1682
Entamoeba histolytica protein kinase, putative 0.0057 0.0357 0.1175
Schistosoma mansoni protein kinase 0.0335 0.4572 1
Entamoeba histolytica p21-activated kinase 0.0234 0.3041 1
Schistosoma mansoni protein kinase 0.0231 0.2989 0.6537
Echinococcus granulosus serine:threonine protein kinase N2 0.0131 0.148 0.1821
Loa Loa (eye worm) TK protein kinase 0.0048 0.0226 0.0226
Loa Loa (eye worm) TK/FER protein kinase 0.0042 0.0133 0.0133
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0159 0.1907 0.2347
Loa Loa (eye worm) hypothetical protein 0.0053 0.0304 0.0304
Onchocerca volvulus Tyrosine kinase homolog 0.0349 0.478 1
Brugia malayi Protein kinase domain containing protein 0.0261 0.345 0.345
Loa Loa (eye worm) hypothetical protein 0.0073 0.0601 0.0601
Loa Loa (eye worm) CMGC/CLK protein kinase 0.007 0.0549 0.0549
Brugia malayi P21-Rho-binding domain containing protein 0.0124 0.1367 0.1367
Trichomonas vaginalis mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative 0.0107 0.1115 0.3732
Schistosoma mansoni serine/threonine protein kinase 0.007 0.0549 0.12
Entamoeba histolytica protein kinase domain containing protein 0.0057 0.0357 0.1175
Schistosoma mansoni tyrosine kinase 0.0085 0.0778 0.1701
Onchocerca volvulus 0.0042 0.0133 0.016
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0057 0.0357 0.044
Entamoeba histolytica protein kinase domain containing protein 0.0057 0.0357 0.1175
Loa Loa (eye worm) hypothetical protein 0.0062 0.0432 0.0432
Loa Loa (eye worm) TK protein kinase 0.0261 0.345 0.345
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0049 0.0237 0.4329
Entamoeba histolytica protein kinase, putative 0.0066 0.0486 0.1598
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0237 0.0519
Loa Loa (eye worm) AGC/PKA protein kinase 0.0049 0.0237 0.0237
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0118 0.1289 0.1586
Echinococcus granulosus tyrosine protein kinase Src42A 0.0053 0.0299 0.0367
Schistosoma mansoni serine/threonine protein kinase 0.0107 0.1115 0.244
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0049 0.0237 0.1872
Echinococcus multilocularis Immunoglobulin 0.0045 0.0175 0.0215
Loa Loa (eye worm) hypothetical protein 0.0222 0.2858 0.2858
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0085 0.0778 0.0957
Brugia malayi Hr1 repeat family protein 0.0165 0.1986 0.1986
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0045 0.0175 0.0382
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0057 0.0357 0.0781
Loa Loa (eye worm) hypothetical protein 0.006 0.0397 0.0397
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0357 0.1195
Schistosoma mansoni tyrosine kinase 0.0085 0.0778 0.1701
Giardia lamblia Kinase, CMGC GSK 0.0057 0.0357 0.0436
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0129 0.1447 0.1447
Loa Loa (eye worm) TK/FER protein kinase 0.0042 0.0133 0.0133
Brugia malayi Protein kinase domain containing protein 0.0335 0.4572 0.4572
Echinococcus granulosus tyrosine protein kinase 0.0261 0.345 0.4245
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0085 0.0778 0.0957
Brugia malayi Protein kinase domain containing protein 0.0042 0.0133 0.0133
Schistosoma mansoni protein kinase 0.0081 0.0724 0.1583
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0118 0.1289 0.1289
Giardia lamblia Kinase, AGC AKT 0.0094 0.0913 0.2454
Echinococcus multilocularis dual specificity protein kinase clk2 0.007 0.0549 0.0675
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0066 0.0486 0.1598
Brugia malayi Protein kinase domain containing protein 0.0042 0.0133 0.0133
Brugia malayi Protein kinase domain containing protein 0.0468 0.6587 0.6587
Echinococcus granulosus tyrosine kinase 0.0042 0.0133 0.0163
Loa Loa (eye worm) hypothetical protein 0.0045 0.0175 0.0175
Echinococcus multilocularis tyrosine protein kinase Blk 0.0072 0.0582 0.0716
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.057 0.8127 1
Schistosoma mansoni protein kinase 0.0124 0.1367 0.299
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0237 0.0519
Echinococcus multilocularis tyrosine protein kinase Abl 0.0135 0.1544 0.1899
Echinococcus granulosus protein tyrosine kinase 0.0275 0.3654 0.4496
Brugia malayi serine/threonine kinase 12 0.0066 0.0486 0.0486
Loa Loa (eye worm) TK/FER protein kinase 0.0042 0.0133 0.0133
Echinococcus multilocularis serine:threonine protein kinase 3 0.0235 0.3054 0.3758
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.007 0.0549 0.3543
Brugia malayi probable protein kinase 0.0232 0.3012 0.3012
Echinococcus multilocularis tyrosine protein kinase 0.0261 0.345 0.4245
Echinococcus multilocularis insulin receptor 0.0151 0.1778 0.2188
Entamoeba histolytica protein kinase domain containing protein 0.0066 0.0486 0.1598
Brugia malayi Protein kinase domain containing protein 0.0099 0.0992 0.0992
Brugia malayi Tyrosine-protein kinase abl-1 0.013 0.1456 0.1456
Entamoeba histolytica protein kinase domain containing protein 0.0099 0.0992 0.3261
Trichomonas vaginalis STE family protein kinase 0.0231 0.2989 1
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0041 0.0116 0.0143
Schistosoma mansoni serine/threonine protein kinase 0.0099 0.0992 0.2169
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0038 0.0065 0.0079
Schistosoma mansoni serine/threonine protein kinase 0.0156 0.1862 0.4073
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.007 0.0549 0.3543
Echinococcus multilocularis 0.0061 0.0418 0.0515
Entamoeba histolytica protein kinase, putative 0.0037 0.0053 0.0173
Brugia malayi Sex muscle abnormal protein 5 0.0036 0.0045 0.0045
Schistosoma mansoni protein kinase 0.0232 0.3012 0.6587
Loa Loa (eye worm) hypothetical protein 0.0062 0.0432 0.0432
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0129 0.1447 0.178
Trichomonas vaginalis AGC family protein kinase 0.0037 0.0053 0.0176
Brugia malayi serine/threonine-protein kinase 6 0.0066 0.0486 0.0486
Echinococcus granulosus serine:threonine protein kinase N2 0.0165 0.1986 0.2444
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0107 0.1115 0.1115
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0486 0.1626
Onchocerca volvulus 0.0042 0.0133 0.016
Schistosoma mansoni serine/threonine protein kinase 0.0165 0.1986 0.4344
Loa Loa (eye worm) TK/FER protein kinase 0.0042 0.0133 0.0133
Loa Loa (eye worm) AGC/AKT protein kinase 0.0037 0.0053 0.0053
Echinococcus granulosus tyrosine protein kinase Blk 0.0072 0.0582 0.0716
Brugia malayi Immunoglobulin I-set domain containing protein 0.0038 0.0065 0.0065
Trichomonas vaginalis STE family protein kinase 0.0132 0.1498 0.501
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.007 0.0549 1
Brugia malayi STE20-like kinase MST 0.0235 0.3054 0.3054
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0057 0.0357 0.1588
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0486 0.1063
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0102 0.104 0.914
Schistosoma mansoni cell adhesion molecule 0.0038 0.0065 0.0141
Loa Loa (eye worm) TK/FER protein kinase 0.0042 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0102 0.104 0.104
Echinococcus granulosus Vam6:Vps39 protein 0.0102 0.104 0.128
Trichomonas vaginalis AGC family protein kinase 0.0037 0.0053 0.0176
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0038 0.0065 0.0079
Schistosoma mansoni tyrosine kinase 0.0258 0.3404 0.7444
Echinococcus granulosus neural Wiskott Aldrich syndrome protein 0.0124 0.1367 0.1682
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0057 0.0357 0.044
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.004 0.0107 0.0132
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0085 0.0778 0.0957
Echinococcus granulosus aurora kinase A 0.0066 0.0486 0.0598
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0057 0.0357 0.6514
Schistosoma mansoni tyrosine kinase 0.0048 0.0219 0.0478
Schistosoma mansoni cell adhesion molecule 0.0068 0.0526 0.115
Toxoplasma gondii AGC kinase 0.0049 0.0237 0.4329
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0078 0.0678 0.0678
Giardia lamblia Kinase, STE STE20 0.0061 0.0416 0.0649
Loa Loa (eye worm) TK/ABL protein kinase 0.0252 0.331 0.331
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0049 0.0237 0.0292
Loa Loa (eye worm) hypothetical protein 0.0074 0.0616 0.0616
Brugia malayi Temporarily assigned gene name protein 59 0.0102 0.104 0.104
Echinococcus multilocularis protein kinase shaggy 0.0057 0.0357 0.044
Schistosoma mansoni tyrosine kinase 0.0151 0.1778 0.3889
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0085 0.0778 0.0957
Brugia malayi protein kinase C II. 0.0041 0.0116 0.0116
Entamoeba histolytica hypothetical protein 0.0124 0.1367 0.4495
Brugia malayi intracellular kinase 0.0057 0.0357 0.0357
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0049 0.0237 0.0292
Trichomonas vaginalis AGC family protein kinase 0.0037 0.0053 0.0176
Echinococcus multilocularis tyrosine kinase 0.0042 0.0133 0.0163
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0038 0.0065 0.0141
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0042 0.0133 0.0163
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0066 0.0486 0.7992
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0129 0.1447 0.178
Leishmania major protein kinase, putative 0.0066 0.0486 0.3296
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0085 0.0778 0.0957
Echinococcus granulosus tyrosine protein kinase Lyn 0.0093 0.0908 0.1118
Loa Loa (eye worm) TK/FAK protein kinase 0.0278 0.37 0.37
Schistosoma mansoni protein kinase 0.0231 0.2989 0.6537
Schistosoma mansoni tyrosine kinase 0.0055 0.0329 0.0719
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0038 0.0065 0.0079
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0094 0.0913 0.0913
Echinococcus multilocularis protein kinase c epsilon type 0.0041 0.0116 0.0143
Brugia malayi Protein kinase domain containing protein 0.0091 0.0877 0.0877
Loa Loa (eye worm) TK protein kinase 0.0072 0.0582 0.0582
Brugia malayi Immunoglobulin I-set domain containing protein 0.0053 0.0304 0.0304
Trypanosoma brucei protein kinase, putative 0.0057 0.0357 0.3085
Brugia malayi Protein kinase domain containing protein 0.0037 0.0053 0.0053
Brugia malayi hypothetical protein 0.0102 0.104 0.104
Echinococcus granulosus tyrosine protein kinase shark 0.0258 0.3404 0.4188
Echinococcus granulosus roundabout 2 0.0038 0.0065 0.0079
Echinococcus granulosus fibroblast growth factor receptor 4 0.0219 0.2814 0.3463
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0061 0.0416 0.2035
Loa Loa (eye worm) TK/FER protein kinase 0.0042 0.0133 0.0133
Giardia lamblia Kinase, CMGC CLK 0.007 0.0549 0.1131
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0159 0.1907 0.2347
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0042 0.0133 0.0163
Echinococcus granulosus tyrosine protein kinase HCK 0.0048 0.0226 0.0278
Plasmodium falciparum glycogen synthase kinase 3 0.0057 0.0357 0.3852
Schistosoma mansoni rap gtpase-activating protein 0.0102 0.104 0.2275
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0066 0.0486 0.0598
Brugia malayi C1-like domain containing protein 0.0078 0.0678 0.0678
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0231 0.2989 0.3678

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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