Detailed information for compound 1597222

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 354.4 | Formula: C20H22N2O4
  • H donors: 2 H acceptors: 2 LogP: 2.66 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1OCC(N1)(CCc1ccc(cc1)OCc1ccccc1C)C(=O)N
  • InChi: 1S/C20H22N2O4/c1-14-4-2-3-5-16(14)12-25-17-8-6-15(7-9-17)10-11-20(18(21)23)13-26-19(24)22-20/h2-9H,10-13H2,1H3,(H2,21,23)(H,22,24)
  • InChiKey: YRYAJQGIYWUGEF-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0013 0.0092 0.02
Trypanosoma brucei unspecified product 0.0013 0.0093 0.0859
Trypanosoma cruzi DNA topoisomerase II, putative 0.0013 0.0092 0.0846
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0181 0.0474
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0181 0.1918
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0013 0.0092 0.0741
Schistosoma mansoni pyruvate dehydrogenase 0.0013 0.0092 0.0092
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0345 0.0345
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0181 0.1918
Loa Loa (eye worm) hypothetical protein 0.0008 0.0022 0.0048
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0319 0.0319
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0008 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0008 0.0022 0.0048
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0019 0.0019
Loa Loa (eye worm) calcium ATPase 0.0008 0.0022 0.0048
Schistosoma mansoni phosphoserine phosphatase 0.0008 0.0022 0.0022
Schistosoma mansoni ATPase 0.0008 0.0022 0.0022
Loa Loa (eye worm) E1-E2 ATPase 0.0008 0.0022 0.0048
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0013 0.0092 0.0846
Trypanosoma cruzi heat shock protein 85, putative 0.0065 0.085 1
Leishmania major developmentally regulated phosphoprotein-like protein 0.0013 0.0092 0.0846
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0093 0.0859
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0046 0.0101
Plasmodium vivax SET domain protein, putative 0.003 0.0345 0.3895
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0046 0.0046
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0013 0.0092 0.1105
Echinococcus multilocularis cation transporting atpase worm 0.0008 0.0022 0.0022
Echinococcus multilocularis heat shock protein 0.0065 0.085 0.085
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0085 0.1147 0.2489
Trichomonas vaginalis receptor histidine kinase, putative 0.0013 0.0092 0.0209
Leishmania major heat shock protein 83-1 0.0065 0.085 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0675 0.1467
Leishmania major heat shock protein 83-1 0.0065 0.085 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0675 0.1949
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0181 0.0181
Echinococcus granulosus copper transporting ATPase 1 0.0008 0.0022 0.0022
Trypanosoma brucei DNA topoisomerase ii 0.0013 0.0092 0.0846
Brugia malayi hypothetical protein 0.0237 0.336 0.7295
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0027 0.0288 0.0794
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0425 0.0425
Schistosoma mansoni cpg binding protein 0.0029 0.0319 0.0319
Loa Loa (eye worm) TOPoisomerase family member 0.0013 0.0092 0.02
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0089 0.0089
Trichomonas vaginalis sensor histidine kinase, putative 0.0013 0.0092 0.0209
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0046 0.0101
Echinococcus granulosus heat shock protein 0.0065 0.085 0.085
Echinococcus multilocularis microtubule associated protein 2 0.069 1 1
Trypanosoma brucei heat shock protein, putative 0.0065 0.085 1
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0013 0.0092 0.0092
Schistosoma mansoni lamin 0.0027 0.0293 0.0293
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0181 0.0181
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.013 0.013
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0181 0.1918
Trichomonas vaginalis DNA topoisomerase II, putative 0.0013 0.0092 0.0209
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0013 0.0092 0.0209
Trypanosoma cruzi metacaspase, putative 0.0053 0.0675 0.7892
Plasmodium falciparum metacaspase-like protein 0.0053 0.0675 0.7892
Echinococcus multilocularis copper transporting ATPase 1 0.0008 0.0022 0.0022
Echinococcus granulosus survival motor neuron protein 1 0.0237 0.336 0.336
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0008 0.0022 0.0022
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0046 0.0046
Schistosoma mansoni heat shock protein 0.0027 0.0288 0.0288
Leishmania major heat shock protein 83-1 0.0065 0.085 1
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0675 0.1949
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0199 0.2805 0.2805
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0027 0.0293 0.0637
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0288 0.0794
Brugia malayi Pre-SET motif family protein 0.003 0.0345 0.0748
Schistosoma mansoni heat shock protein 0.0065 0.085 0.085
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.013 0.1299
Treponema pallidum heat shock protein 90 0.0052 0.0656 1
Toxoplasma gondii heat shock protein 90, putative 0.0065 0.085 1
Trypanosoma brucei heat shock protein, putative 0.0065 0.085 1
Echinococcus granulosus cation transporting ATPase 13A3 0.0008 0.0022 0.0022
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0425 0.0425
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0053 0.0675 0.7892
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0046 0.0046
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0013 0.0092 0.0209
Trypanosoma brucei heat shock protein 84, putative 0.0027 0.0288 0.3215
Trypanosoma brucei DNA polymerase eta, putative 0.0045 0.0554 0.6422
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0013 0.0092 0.1105
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0053 0.0675 0.0675
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0013 0.0092 0.0846
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0675 0.1949
Leishmania major heat shock protein 83-1 0.0065 0.085 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0181 0.1918
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0046 0.0046
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0425 0.0425
Trypanosoma brucei unspecified product 0.0019 0.0181 0.1918
Leishmania major heat shock protein, putative 0.0027 0.0288 0.3215
Trypanosoma cruzi heat shock protein 90, putative 0.0065 0.085 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0345 0.0345
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0008 0.0022 0.0048
Echinococcus granulosus caspase 8 0.0053 0.0675 0.0675
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.0554 0.6422
Trypanosoma brucei heat shock protein 90, putative 0.0065 0.085 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.2954 0.6414
Brugia malayi tumor suppressor. 0.0322 0.4606 1
Plasmodium falciparum heat shock protein 90 0.0065 0.085 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0711 0.8321
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.001 0.0047 0.0301
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.013 0.013
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0013 0.0092 0.0741
Brugia malayi Hsp90 protein 0.0027 0.0288 0.0626
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0013 0.0092 0.0846
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0052 0.0656 0.0656
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0046 0.0101
Echinococcus granulosus caspase 3 0.0146 0.2028 0.2028
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0675 0.1949
Giardia lamblia DINP protein human, muc B family 0.0019 0.0181 0.1918
Brugia malayi hypothetical protein 0.0027 0.0297 0.0644
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.0022 0.0022
Trypanosoma brucei heat shock protein, putative 0.0065 0.085 1
Mycobacterium tuberculosis Possible two component sensor kinase 0.0013 0.0092 0.1105
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.0376 0.4273
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0013 0.0092 0.1105
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0046 0.0046
Trichomonas vaginalis heat shock protein, putative 0.0065 0.085 0.2469
Schistosoma mansoni cation-transporting ATPase 0.0008 0.0022 0.0022
Schistosoma mansoni microtubule-associated protein tau 0.069 1 1
Brugia malayi kinase, mitochondrial precursor 0.0013 0.0092 0.02
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0046 0.0046
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0088 0.1188 0.258
Schistosoma mansoni cation-transporting atpase worm 0.0008 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0026 0.0286 0.0621
Onchocerca volvulus 0.0029 0.0319 0.0885
Loa Loa (eye worm) tumor suppressor 0.0322 0.4606 1
Echinococcus multilocularis expressed protein 0.0033 0.0387 0.0387
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0046 0.0046
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0027 0.0288 0.0288
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0181 0.1918
Echinococcus multilocularis phospholipid transporting ATPase IIB 0.0008 0.0022 0.0022
Schistosoma mansoni cpg binding protein 0.003 0.0343 0.0343
Trypanosoma cruzi metacaspase, putative 0.0053 0.0675 0.7892
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0047 0.0301
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0046 0.0046
Echinococcus multilocularis survival motor neuron protein 1 0.0237 0.336 0.336
Mycobacterium ulcerans heat shock protein 90 0.0052 0.0656 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0019 0.0019
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0008 0.0022 0.0048
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0293 0.0637
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0046 0.0101
Trypanosoma brucei Heat shock protein 83, putative 0.0065 0.085 1
Echinococcus multilocularis dnaJ subfamily B 0.0409 0.5886 0.5886
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0046 0.0046
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0019 0.0019
Mycobacterium leprae Probable two component sensor kinase MprB 0.0013 0.0092 0.1105
Schistosoma mansoni hypothetical protein 0.0027 0.0297 0.0297
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0046 0.0101
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0013 0.0092 0.1105
Plasmodium falciparum DNA topoisomerase 2 0.0013 0.0092 0.0846
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0013 0.0092 0.1105
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0013 0.0092 0.0846
Echinococcus granulosus phospholipid transporting ATPase IIB 0.0008 0.0022 0.0022
Echinococcus granulosus dna polymerase eta 0.0045 0.0554 0.0554
Echinococcus granulosus cation transporting ATPase 13A1 0.0008 0.0022 0.0022
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0622 0.0622
Echinococcus granulosus cation transporting atpase worm 0.0008 0.0022 0.0022
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.013 0.1299
Trypanosoma cruzi heat shock protein 85, putative 0.0065 0.085 1
Trichomonas vaginalis heat shock protein, putative 0.0052 0.0656 0.1891
Trypanosoma cruzi heat shock protein 85, putative 0.0065 0.085 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0047 0.0301
Schistosoma mansoni DNA polymerase eta 0.0045 0.0554 0.0554
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0008 0.0022 0.0022
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0181 0.0393
Loa Loa (eye worm) hypothetical protein 0.0053 0.0675 0.1467
Schistosoma mansoni hypothetical protein 0.0027 0.0297 0.0297
Plasmodium falciparum endoplasmin, putative 0.004 0.0482 0.5556
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0046 0.0046
Leishmania major heat shock protein 83-1 0.0065 0.085 1
Trichomonas vaginalis heat shock protein, putative 0.0052 0.0656 0.1891
Leishmania major heat shock protein 83-1 0.0065 0.085 1
Leishmania major heat shock protein 83-1 0.0065 0.085 1
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0013 0.0092 0.1105
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0376 0.4273
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.013 0.1299
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0675 0.1949
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.013 0.013
Plasmodium vivax heat shock protein 86, putative 0.0065 0.085 1
Leishmania major heat shock protein 83-1 0.0065 0.085 1
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0199 0.2805 0.2805
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0013 0.0092 0.1105
Loa Loa (eye worm) hypothetical protein 0.0237 0.336 0.7295
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0181 0.0474
Entamoeba histolytica heat shock protein 90, putative 0.0065 0.085 1
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0013 0.0092 1
Brugia malayi ImpB/MucB/SamB family protein 0.0045 0.0554 0.1202
Toxoplasma gondii heat shock protein HSP90 0.0065 0.085 1
Plasmodium vivax hypothetical protein, conserved 0.0053 0.0675 0.7892
Plasmodium vivax heat shock protein, putative 0.0027 0.0288 0.3215
Echinococcus multilocularis cation transporting ATPase 13A3 0.0008 0.0022 0.0022
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0675 0.1949
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.013 0.013
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.013 0.1696
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0053 0.0675 0.7892
Brugia malayi intermediate filament protein 0.0027 0.0293 0.0637
Plasmodium falciparum heat shock protein 90, putative 0.0027 0.0288 0.3215
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0181 0.2504
Entamoeba histolytica hypothetical protein 0.0036 0.0425 0.4867
Schistosoma mansoni hypothetical protein 0.0036 0.0425 0.0425
Brugia malayi potential phospholipid-transporting ATPase IIB, putative 0.0008 0.0022 0.0048
Onchocerca volvulus 0.0049 0.0622 0.179
Leishmania major mitochondrial DNA topoisomerase II 0.0013 0.0092 0.0846
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.001 0.0047 0.0301
Echinococcus granulosus heat shock protein 90 0.0052 0.0656 0.0656
Loa Loa (eye worm) hypothetical protein 0.0008 0.0022 0.0048
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0181 0.1918
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0181 0.1918
Brugia malayi hypothetical protein 0.0088 0.1188 0.258
Giardia lamblia Heat shock protein HSP 90-alpha 0.0065 0.085 1
Brugia malayi Pre-SET motif family protein 0.0209 0.2954 0.6414
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.001 0.0046 0.0101
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.0022 0.0022
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0345 0.0345
Schistosoma mansoni cpg binding protein 0.003 0.0343 0.0343
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0013 0.0092 0.0741
Onchocerca volvulus 0.0048 0.0604 0.1737
Leishmania major heat shock protein 83-1 0.0065 0.085 1
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0013 0.0092 0.1105
Brugia malayi nuclear receptor NHR-88 0.001 0.0046 0.0101
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0052 0.0656 0.7659
Brugia malayi Temporarily assigned gene name protein 44 0.0027 0.0297 0.0644
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0387 0.0841
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0046 0.0101
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0013 0.0092 0.1105
Brugia malayi Na,K-ATPase alpha subunit 0.0008 0.0022 0.0048
Loa Loa (eye worm) histone methyltransferase 0.001 0.0045 0.0097
Schistosoma mansoni thyroid hormone receptor 0.001 0.0046 0.0046
Mycobacterium ulcerans two component sensor kinase MprB 0.0013 0.0092 0.1105
Leishmania major heat shock protein 83-1 0.0065 0.085 1
Schistosoma mansoni voltage-gated potassium channel 0.0085 0.1147 0.1147
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0293 0.0637
Trichomonas vaginalis receptor histidine kinase, putative 0.0013 0.0092 0.0209
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0675 0.1949
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0013 0.0092 0.1105
Loa Loa (eye worm) hypothetical protein 0.0013 0.0082 0.0177
Schistosoma mansoni endoplasmin 0.0065 0.085 0.085
Entamoeba histolytica DNA topoisomerase II, putative 0.0013 0.0092 0.0846
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0046 0.0046
Schistosoma mansoni voltage-gated potassium channel 0.0085 0.1147 0.1147
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0046 0.0101
Loa Loa (eye worm) hypothetical protein 0.001 0.0046 0.0101
Echinococcus granulosus dnaJ subfamily B 0.0409 0.5886 0.5886
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0319 0.0692
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0046 0.0046
Echinococcus multilocularis tumor protein p63 0.0338 0.4845 0.4845
Trypanosoma brucei metacaspase MCA2 0.0053 0.0675 0.7892
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.013 0.1299
Echinococcus granulosus phospholipid transporting ATPase VA 0.0008 0.0022 0.0022
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0043 0.0093
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0013 0.0092 0.0209
Mycobacterium ulcerans DNA gyrase subunit B 0.0013 0.0092 0.1105
Trichomonas vaginalis endoplasmin, putative 0.004 0.0482 0.1372
Echinococcus multilocularis caspase 3 0.0146 0.2028 0.2028
Echinococcus multilocularis caspase 0.0199 0.2805 0.2805
Echinococcus multilocularis caspase 8 0.0053 0.0675 0.0675
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0181 0.1918
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0046 0.0046
Loa Loa (eye worm) endoplasmin 0.0065 0.085 0.1845
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0181 0.0393
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0675 0.1949
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0045 0.0045
Mycobacterium ulcerans putative regultory protein 0.0013 0.0092 0.1105
Trypanosoma brucei heat shock protein, putative 0.0065 0.085 1
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0013 0.0092 0.0846
Echinococcus granulosus potassium voltage gated channel protein 0.0085 0.1147 0.1147
Schistosoma mansoni hypothetical protein 0.0409 0.5886 0.5886
Loa Loa (eye worm) hypothetical protein 0.003 0.0345 0.0748
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0181 0.1918
Schistosoma mansoni heat shock protein 0.0065 0.085 0.085
Leishmania major heat shock protein 83-1 0.0065 0.085 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.1147 0.2489
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0181 0.1918
Echinococcus granulosus dna polymerase kappa 0.0019 0.0181 0.0181
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.013 0.1299
Echinococcus multilocularis lamin dm0 0.0027 0.0293 0.0293
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.013 0.1299
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0093 0.0859
Brugia malayi CXXC zinc finger family protein 0.0029 0.0319 0.0692
Leishmania major heat shock protein 83-1 0.0065 0.085 1
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0013 0.0092 0.1105
Echinococcus multilocularis cation transporting ATPase 13A1 0.0008 0.0022 0.0022
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0675 0.1949
Giardia lamblia Pms1-like protein 0.0013 0.0092 0.0846
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0008 0.0022 0.0048
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0046 0.0101
Brugia malayi E1-E2 ATPase family protein 0.0008 0.0022 0.0048
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0046 0.0046
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0046 0.0046
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0013 0.0092 0.0209
Brugia malayi nuclear hormone receptor 0.001 0.0046 0.0101
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0013 0.0092 0.1105
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0045 0.0045
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0046 0.0072
Trypanosoma cruzi DNA topoisomerase II, putative 0.0013 0.0092 0.0846
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0046 0.0101
Echinococcus granulosus cpg binding protein 0.003 0.0343 0.0343
Trypanosoma brucei Metacaspase-4 0.0053 0.0675 0.7892
Echinococcus granulosus heat shock protein 90 0.0065 0.085 0.085
Loa Loa (eye worm) hypothetical protein 0.0013 0.0082 0.0177
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0013 0.0092 0.0209
Onchocerca volvulus 0.0238 0.3375 1
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0052 0.0656 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0046 0.0101
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0046 0.0046
Schistosoma mansoni atpase class VI type 11c 0.0008 0.0022 0.0022
Trichomonas vaginalis heat shock protein, putative 0.004 0.0482 0.1372
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0181 0.1918
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.011 0.0239
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0008 0.0022 0.0048
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0013 0.0092 0.1105
Echinococcus granulosus tumor protein p63 0.0338 0.4845 0.4845
Plasmodium falciparum DNA gyrase subunit B 0.0013 0.0092 0.0846
Loa Loa (eye worm) hypothetical protein 0.0008 0.0022 0.0048
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0027 0.0288 0.0288
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0806 0.0806
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0019 0.0019
Leishmania major DNA polymerase eta, putative 0.0031 0.0359 0.4069
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0376 0.4273
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0181 0.1918
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0046 0.0046
Leishmania major heat shock protein 83-1 0.0065 0.085 1
Brugia malayi heat shock protein 90 0.0065 0.085 0.1845
Leishmania major DNA polymerase eta, putative 0.0045 0.0554 0.6422
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0046 0.0046
Brugia malayi Cell death protein 3 precursor 0.0053 0.0675 0.1467
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0008 0.0022 0.0022
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0046 0.0101
Trypanosoma cruzi metacaspase, putative 0.0053 0.0675 0.7892
Loa Loa (eye worm) hypothetical protein 0.001 0.0046 0.0101
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.013 0.1299
Plasmodium falciparum metacaspase 1 0.0053 0.0675 0.7892
Trypanosoma cruzi metacaspase 5, putative 0.0053 0.0675 0.7892
Schistosoma mansoni rotamase 0.0033 0.0387 0.0387
Brugia malayi Endoplasmin precursor 0.0065 0.085 0.1845
Trypanosoma brucei heat shock protein, putative 0.0065 0.085 1
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0013 0.0092 0.0846
Trichomonas vaginalis rotamase, putative 0.0033 0.0376 0.1055
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0046 0.0101
Schistosoma mansoni thyroid hormone receptor 0.001 0.0046 0.0046
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0013 0.0092 0.1105
Echinococcus multilocularis dna polymerase eta 0.0045 0.0554 0.0554
Schistosoma mansoni caspase-3 (C14 family) 0.0199 0.2805 0.2805
Trypanosoma brucei metacaspase 5, putative 0.0053 0.0675 0.7892
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0345 0.0345
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0013 0.0092 0.1105
Echinococcus granulosus protein quaking 0.0027 0.0297 0.0297
Loa Loa (eye worm) hypothetical protein 0.0027 0.0297 0.0644
Echinococcus granulosus lamin dm0 0.0027 0.0293 0.0293
Echinococcus multilocularis endoplasmin 0.0052 0.0656 0.0656
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0047 0.0301
Leishmania major heat shock protein 83-1 0.0065 0.085 1
Schistosoma mansoni coup transcription factor 0.001 0.0046 0.0046
Loa Loa (eye worm) heat shock protein 75 0.0027 0.0288 0.0626
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0046 0.0046
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0046 0.0101
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0013 0.0092 0.1105
Trypanosoma cruzi heat shock protein 90, putative 0.0038 0.046 0.529
Loa Loa (eye worm) hypothetical protein 0.0008 0.0022 0.0048
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0008 0.0022 0.0022
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0013 0.0092 0.0092
Leishmania major hypothetical protein, conserved 0.0013 0.0092 0.0846
Loa Loa (eye worm) hypothetical protein 0.0013 0.0092 0.02
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0046 0.0046
Schistosoma mansoni caspase-7 (C14 family) 0.0199 0.2805 0.2805
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0046 0.0046
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.011 0.0239
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0387 0.0841
Entamoeba histolytica hypothetical protein 0.0036 0.0425 0.4867
Plasmodium vivax DNA topoisomerase II, putative 0.0013 0.0092 0.0846
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0013 0.0092 0.02
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0019 0.0019
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0359 0.4069
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0046 0.0046
Schistosoma mansoni nuclear hormone receptor 0.001 0.0046 0.0046
Entamoeba histolytica hypothetical protein 0.0036 0.0425 0.4867
Trypanosoma brucei metacaspase 0.0053 0.0675 0.7892
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0359 0.4069
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0675 0.1949
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0046 0.0046
Toxoplasma gondii Hsp90 domain-containing protein 0.0027 0.0288 0.3215
Echinococcus multilocularis lamin 0.0027 0.0293 0.0293
Echinococcus granulosus FTZ F1 alpha 0.001 0.0046 0.0046
Schistosoma mansoni intermediate filament proteins 0.0027 0.0293 0.0293
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0053 0.0675 0.7892
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0675 0.1949
Schistosoma mansoni cation-transporting atpase worm 0.0008 0.0022 0.0022
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0345 0.0345
Leishmania major DNA topoisomerase ii 0.0013 0.0092 0.0846
Leishmania major metacaspase, putative 0.0053 0.0675 0.7892
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0387 0.1089
Plasmodium vivax DNA gyrase subunit B, putative 0.0013 0.0092 0.0846
Brugia malayi Probable cation-transporting ATPase C10C6.6 in chromosome IV 0.0008 0.0022 0.0048
Echinococcus multilocularis caspase 2 0.0053 0.0675 0.0675
Loa Loa (eye worm) hypothetical protein 0.0049 0.0622 0.1351
Onchocerca volvulus 0.003 0.0345 0.0962
Loa Loa (eye worm) heat shock protein 90 0.0065 0.085 0.1845
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0046 0.0101
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0053 0.0675 0.1467
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0181 0.0181
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0181 0.1918
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0046 0.0072
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0013 0.0092 0.1105
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.0022 0.0022
Leishmania major heat shock protein 83-1 0.0065 0.085 1
Trypanosoma brucei heat shock protein, putative 0.0065 0.085 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0181 0.2504
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0675 0.1949
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0376 0.4273
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.013 0.1299
Loa Loa (eye worm) hypothetical protein 0.001 0.0046 0.0101
Chlamydia trachomatis DNA gyrase subunit B 0.0013 0.0092 1
Echinococcus multilocularis phospholipid transporting ATPase VA 0.0008 0.0022 0.0022
Brugia malayi isocitrate dehydrogenase 0.0016 0.013 0.0282
Onchocerca volvulus 0.0027 0.0293 0.0808
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0013 0.0092 0.1105
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0345 0.0345
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0013 0.0092 0.0209
Echinococcus granulosus caspase 2 0.0053 0.0675 0.0675
Trypanosoma brucei developmentally regulated phosphoprotein 0.0013 0.0092 0.0846
Plasmodium vivax heat shock protein 90, putative 0.0027 0.0288 0.3215
Schistosoma mansoni ATPase 0.0008 0.0022 0.0022
Entamoeba histolytica hypothetical protein 0.0036 0.0425 0.4867
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0013 0.0092 0.0092
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0013 0.0092 0.0092
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0376 0.4273
Schistosoma mansoni survival motor neuron protein 0.0048 0.0604 0.0604
Schistosoma mansoni hypothetical protein 0.0048 0.0604 0.0604
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0046 0.0101
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0085 0.1147 0.1147
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0013 0.0092 0.0846
Schistosoma mansoni eyes absent homolog 0.0088 0.1188 0.1188
Trypanosoma cruzi heat shock protein 85, putative 0.0052 0.0656 0.7659
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0181 0.1918
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0046 0.0101
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0045 0.0554 0.1202
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0013 0.0092 0.0209
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0013 0.0092 0.1105
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0675 0.1949
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0013 0.0092 0.0092
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0376 0.4273
Schistosoma mansoni caspase-7 (C14 family) 0.0053 0.0675 0.0675
Onchocerca volvulus Cell death protein 3 homolog 0.0053 0.0675 0.1949
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0013 0.0092 0.0846
Chlamydia trachomatis DNA gyrase subunit B 0.0013 0.0092 1
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0013 0.0092 0.1105
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.013 0.0282
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0013 0.0092 0.0846
Toxoplasma gondii DNA topoisomerase 2, putative 0.0013 0.0092 0.0846
Echinococcus multilocularis heat shock protein 90 0.0065 0.085 0.085
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0046 0.0046
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.013 0.013
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0008 0.0022 0.0022
Trypanosoma cruzi heat shock protein, putative 0.0027 0.0288 0.3215
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0181 0.1918
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0181 0.1918
Plasmodium falciparum heat shock protein 90, putative 0.0027 0.0288 0.3215
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0046 0.0101
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0181 0.0181
Leishmania major heat shock protein 83-1 0.0065 0.085 1
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0013 0.0092 0.02
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0013 0.0092 0.0846
Echinococcus multilocularis protein quaking 0.0027 0.0297 0.0297
Trypanosoma cruzi metacaspase, putative 0.0053 0.0675 0.7892
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0082 0.1092 0.1092
Plasmodium vivax metacaspase 1, putative 0.0053 0.0675 0.7892
Trypanosoma brucei metacaspase MCA3 0.0053 0.0675 0.7892
Trypanosoma brucei heat shock protein, putative 0.0065 0.085 1
Echinococcus multilocularis potassium voltage gated channel protein 0.0085 0.1147 0.1147
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0092 0.0846
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0675 0.1949
Loa Loa (eye worm) hypothetical protein 0.001 0.0046 0.0101
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0181 0.1918
Entamoeba histolytica heat shock protein 90, putative 0.0065 0.085 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0046 0.0101
Mycobacterium leprae Probable two-component sensor kinase 0.0013 0.0092 0.1105
Loa Loa (eye worm) hypothetical protein 0.0013 0.0092 0.02
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0046 0.0101
Echinococcus granulosus lamin 0.0027 0.0293 0.0293
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0013 0.0092 0.1105
Trichomonas vaginalis rotamase, putative 0.0033 0.0387 0.1089
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0046 0.0101
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0604 0.1312
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0046 0.0101
Echinococcus granulosus intermediate filament protein 0.0027 0.0293 0.0293
Echinococcus granulosus expressed protein 0.0033 0.0387 0.0387
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0013 0.0092 0.0209
Mycobacterium tuberculosis Probable two component sensor kinase 0.0013 0.0092 0.1105
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0293 0.0637
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0181 0.1918
Mycobacterium tuberculosis Conserved protein 0.0013 0.0092 0.1105
Loa Loa (eye worm) hypothetical protein 0.001 0.0046 0.0101
Brugia malayi ecdysteroid receptor 0.001 0.0046 0.0101
Schistosoma mansoni cation-transporting atpase 13a1 (G-box binding protein) 0.0008 0.0022 0.0022
Giardia lamblia Grp94/Hsp90 0.0052 0.0656 0.7659
Onchocerca volvulus 0.001 0.0046 0.0072
Trypanosoma cruzi Heat shock protein 83, putative 0.0065 0.085 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.1188 0.258
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0027 0.0288 0.3215
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0181 0.1918
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0046 0.0101
Trichomonas vaginalis heat shock protein, putative 0.0052 0.0656 0.1891
Onchocerca volvulus 0.0027 0.0293 0.0808
Plasmodium vivax endoplasmin, putative 0.0065 0.085 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0046 0.0101
Echinococcus granulosus endoplasmin 0.0052 0.0656 0.0656
Toxoplasma gondii heat shock protein 75, putative 0.0027 0.0288 0.3215
Leishmania major DNA polymerase kappa, putative 0.0019 0.0181 0.1918
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0345 0.3895
Leishmania major heat shock protein 83-1 0.0065 0.085 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0093 0.0859
Brugia malayi Probable DNA topoisomerase II 0.0013 0.0092 0.02
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0046 0.0101
Schistosoma mansoni endoplasmin 0.0065 0.085 0.085
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0181 0.0181
Trypanosoma cruzi heat shock protein 90, putative 0.0052 0.0656 0.7659
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0052 0.0656 1
Brugia malayi hypothetical protein 0.0008 0.0022 0.0048
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0046 0.0046
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.013 0.1299
Trypanosoma brucei heat shock protein 90, putative 0.0065 0.085 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0181 0.2504
Giardia lamblia Heat shock protein HSP 90-alpha 0.0052 0.0656 0.7659
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0046 0.0072
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.0022 0.0022
Schistosoma mansoni type V p-type atpase isoform 0.0008 0.0022 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0046 0.0101
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0181 0.2504
Echinococcus granulosus hypothetical protein 0.0027 0.0297 0.0297
Schistosoma mansoni DNA topoisomerase II 0.0013 0.0092 0.0092
Trypanosoma brucei unspecified product 0.0013 0.0093 0.0859
Trichomonas vaginalis set domain proteins, putative 0.0238 0.3375 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0013 0.0089 0.0193
Trypanosoma cruzi metacaspase 5, putative 0.0053 0.0675 0.7892
Brugia malayi steroid hormone receptor 0.001 0.0046 0.0101
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0013 0.0092 0.1105
Brugia malayi E1-E2 ATPase family protein 0.0008 0.0022 0.0048
Schistosoma mansoni copper ABC transporter ATPase 0.0008 0.0022 0.0022
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.013 0.013
Mycobacterium ulcerans two component regulator - sensor kinase 0.0013 0.0092 0.1105
Trypanosoma brucei heat shock protein, putative 0.0065 0.085 1
Brugia malayi Isocitrate dehydrogenase 0.0016 0.013 0.0282
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0013 0.0092 0.0846
Schistosoma mansoni lamin 0.0027 0.0293 0.0293
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0013 0.0092 0.1105
Echinococcus multilocularis heat shock protein 90 0.0052 0.0656 0.0656
Brugia malayi hypothetical protein 0.0036 0.0425 0.0923
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0052 0.0656 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0046 0.0101
Echinococcus multilocularis cpg binding protein 0.003 0.0343 0.0343
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0675 0.1949
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0345 0.0345
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0008 0.0022 0.0022
Echinococcus granulosus caspase 0.0199 0.2805 0.2805
Echinococcus multilocularis musashi 0.0027 0.0293 0.0293

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) Agonist activity at EGFP-tagged S1P1 receptor expressed in human UOS2 cells assessed as receptor internalization in endosomes after 60 mins ChEMBL. 22119341

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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