Detailed information for compound 1603782

Basic information

Technical information
  • TDR Targets ID: 1603782
  • Name: ethyl 5-[(2,6-dichlorophenyl)-[5-ethoxycarbon yl-2-hydroxy-6-(4-methylpiperazin-1-yl)-4-oxo -1H-pyridin-3-yl]methyl]-6-hydroxy-2-(4-methy lpiperazin-1-yl)-4-oxo-1H-pyridine-3-carboxyl ate
  • MW: 719.612 | Formula: C33H40Cl2N6O8
  • H donors: 4 H acceptors: 6 LogP: 3.13 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCOC(=O)c1c([nH]c(=O)c(c1O)C(c1c(=O)[nH]c(c(c1O)C(=O)OCC)N1CCN(CC1)C)c1c(Cl)cccc1Cl)N1CCN(CC1)C
  • InChi: 1S/C33H40Cl2N6O8/c1-5-48-32(46)24-26(42)22(30(44)36-28(24)40-14-10-38(3)11-15-40)21(20-18(34)8-7-9-19(20)35)23-27(43)25(33(47)49-6-2)29(37-31(23)45)41-16-12-39(4)13-17-41/h7-9,21H,5-6,10-17H2,1-4H3,(H2,36,42,44)(H2,37,43,45)
  • InChiKey: WKIWQXWKYRFBMU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-[(2,6-dichlorophenyl)-[5-ethoxycarbonyl-2-hydroxy-6-(4-methyl-1-piperazinyl)-4-oxo-1H-pyridin-3-yl]methyl]-6-hydroxy-2-(4-methyl-1-piperazinyl)-4-oxo-1H-pyridine-3-carboxylic acid ethyl ester
  • 5-[[5-carbethoxy-2-hydroxy-4-keto-6-(4-methylpiperazin-1-yl)-1H-pyridin-3-yl]-(2,6-dichlorophenyl)methyl]-6-hydroxy-4-keto-2-(4-methylpiperazin-1-yl)-1H-pyridine-3-carboxylic acid ethyl ester
  • NSC722829

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0028 0.0202 0.0202
Loa Loa (eye worm) intermediate filament protein 0.0019 0.0091 0.0091
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0011 0.0005 0.0005
Mycobacterium tuberculosis Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase) 0.03 0.3388 1
Echinococcus granulosus dUTP pyrophosphatase 0.0864 1 1
Toxoplasma gondii NADPH-glutathione reductase 0.0011 0.0005 0.0005
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0012 0.001 0.001
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.004 0.0342 0.0996
Plasmodium vivax acyl-CoA synthetase, putative 0.003 0.0223 0.0223
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0011 0.0005 0.0005
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0336 0.0332
Entamoeba histolytica hypothetical protein 0.0564 0.6484 0.648
Brugia malayi Nuclear hormone receptor E75 0.0013 0.0028 0.0028
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0013 0.0028 0.0028
Brugia malayi hypothetical protein 0.0013 0.0028 0.0028
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0012 0.001 0.001
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0084 0.086 0.086
Onchocerca volvulus 0.0013 0.0028 0.021
Echinococcus granulosus expressed conserved protein 0.0156 0.1705 0.1705
Chlamydia trachomatis deoxycytidine triphosphate deaminase 0.03 0.3388 0.3385
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0407 0.0407
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0028 0.0202 0.0202
Loa Loa (eye worm) hypothetical protein 0.004 0.0336 0.0336
Echinococcus multilocularis GPCR, family 2 0.0027 0.0184 0.0184
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0028 0.0202 0.0202
Echinococcus multilocularis protein patched 0.0071 0.0709 0.0709
Toxoplasma gondii thioredoxin reductase 0.0033 0.0256 0.0256
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0071 0.0709 0.0709
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0028
Brugia malayi photoreceptor-specific nuclear receptor 0.0028 0.0202 0.0202
Brugia malayi Niemann-Pick C1 protein precursor 0.0166 0.1823 0.1823
Entamoeba histolytica hypothetical protein 0.03 0.3388 0.3382
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0027 0.0184 0.0184
Plasmodium falciparum thioredoxin reductase 0.0033 0.0256 0.0256
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0011 0.0005 0.0142
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0012 0.001 0.001
Plasmodium vivax hypothetical protein, conserved 0.004 0.0336 0.0336
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0013 0.0028 0.021
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0028 0.0202 0.0202
Schistosoma mansoni steroid hormone receptor ad4bp 0.0028 0.0202 0.0202
Onchocerca volvulus 0.0013 0.0028 0.021
Mycobacterium ulcerans deoxycytidine triphosphate deaminase 0.03 0.3388 1
Toxoplasma gondii propionate-CoA ligase 0.0012 0.001 0.001
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0011 0.0005 0.0139
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0028
Brugia malayi hypothetical protein 0.0164 0.1792 0.1792
Loa Loa (eye worm) hypothetical protein 0.003 0.0223 0.0223
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0336 0.0992
Loa Loa (eye worm) hypothetical protein 0.0084 0.086 0.086
Plasmodium falciparum glutathione reductase 0.0033 0.0256 0.0256
Mycobacterium ulcerans hypothetical protein 0.004 0.0336 0.098
Echinococcus multilocularis expressed conserved protein 0.0156 0.1705 0.1705
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0075 0.0748 0.2206
Brugia malayi orphan nuclear receptor NR2E1 0.0013 0.0028 0.0028
Plasmodium falciparum acyl-CoA synthetase 0.003 0.0223 0.0223
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0202 0.0202
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0202 0.0202
Loa Loa (eye worm) glutathione reductase 0.0033 0.0256 0.0256
Mycobacterium tuberculosis Conserved protein 0.004 0.0336 0.0992
Mycobacterium ulcerans acetyl-CoA synthetase 0.0012 0.001 0.0015
Plasmodium vivax deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.0864 1 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0336 0.0336
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.004 0.0342 0.0996
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0204 0.0601
Schistosoma mansoni hypothetical protein 0.0069 0.0679 0.0679
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0011 0.0005 0.0142
Loa Loa (eye worm) hypothetical protein 0.0015 0.0046 0.0046
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0033 0.0263 0.0263
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0864 1 1
Mycobacterium ulcerans acyl-CoA synthetase 0.004 0.0342 0.0996
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0012 0.001 0.0029
Mycobacterium ulcerans acyl-CoA synthetase 0.004 0.0342 0.0996
Brugia malayi nuclear hormone receptor 0.0013 0.0028 0.0028
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0015 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.004 0.0342 0.0342
Mycobacterium ulcerans acyl-CoA synthetase 0.0012 0.001 0.0015
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0011 0.0005 0.0005
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0028 0.0202 0.0202
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative 0.0864 1 1
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0012 0.001 0.001
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0012 0.001 0.0015
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0083 0.0845 0.2473
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0075 0.0748 0.2206
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0075 0.0748 0.2206
Schistosoma mansoni nuclear hormone receptor 0.0013 0.0028 0.0028
Wolbachia endosymbiont of Brugia malayi dUTPase 0.0864 1 1
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0012 0.001 0.0015
Brugia malayi latrophilin 2 splice variant baaae 0.0058 0.0547 0.0547
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0012 0.001 0.001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0013 0.0028 0.0028
Schistosoma mansoni hypothetical protein 0.0069 0.0679 0.0679
Brugia malayi AMP-binding enzyme family protein 0.004 0.0342 0.0342
Loa Loa (eye worm) hypothetical protein 0.004 0.0342 0.0342
Loa Loa (eye worm) beta-lactamase 0.004 0.0336 0.0336
Schistosoma mansoni hypothetical protein 0.0027 0.0184 0.0184
Brugia malayi conserved hypotetical protein 0.0013 0.0028 0.0028
Echinococcus multilocularis lamin 0.0019 0.0091 0.0091
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0202 0.0202
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0011 0.0005 0.0142
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0864 1 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.003 0.0223 0.0645
Leishmania major hypothetical protein, conserved 0.004 0.0336 0.984
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0028
Schistosoma mansoni hypothetical protein 0.0287 0.3231 0.3231
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0028 0.0202 0.0202
Schistosoma mansoni nuclear hormone receptor 0.0013 0.0028 0.0028
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0204 0.0601
Loa Loa (eye worm) hypothetical protein 0.0028 0.0202 0.0202
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0562 0.6457 0.6457
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0028 0.0202 0.0202
Brugia malayi CHE-14 protein 0.0071 0.0709 0.0709
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0015 0.0046 0.0046
Wolbachia endosymbiont of Brugia malayi deoxycytidine triphosphate deaminase 0.03 0.3388 0.3385
Onchocerca volvulus Huntingtin homolog 0.0085 0.0867 1
Entamoeba histolytica hypothetical protein 0.0864 1 1
Trypanosoma cruzi trypanothione reductase, putative 0.0011 0.0005 0.0142
Loa Loa (eye worm) hypothetical protein 0.004 0.0336 0.0336
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0012 0.001 0.001
Echinococcus granulosus sterol regulatory element binding protein 0.0071 0.0709 0.0709
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0012 0.001 0.0029
Brugia malayi hypothetical protein 0.0013 0.0028 0.0028
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0013 0.0028 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0028 0.0202 0.0202
Brugia malayi nuclear receptor RXR 0.0015 0.0046 0.0046
Echinococcus granulosus intermediate filament protein 0.0019 0.0091 0.0091
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0011 0.0005 0.0005
Plasmodium falciparum glutathione reductase 0.0011 0.0005 0.0005
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0013 0.0028 0.0028
Echinococcus granulosus tumor protein p63 0.0234 0.2616 0.2616
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0027 0.0184 0.0184
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0011 0.0005 0.0142
Plasmodium vivax acetyl-CoA synthetase, putative 0.0012 0.001 0.001
Echinococcus multilocularis nuclear receptor nhr 48 0.0013 0.0028 0.0028
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0011 0.0005 0.0142
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0028 0.0202 0.0202
Entamoeba histolytica acyl-CoA synthetase, putative 0.004 0.0342 0.0332
Onchocerca volvulus 0.0033 0.0263 0.296
Schistosoma mansoni hypothetical protein 0.0027 0.0184 0.0184
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0012 0.001 0.0029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0028 0.0202 0.0202
Schistosoma mansoni lamin 0.0019 0.0091 0.0091
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0407 0.0407
Echinococcus granulosus nuclear receptor nhr 48 0.0013 0.0028 0.0028
Mycobacterium ulcerans acyl-CoA synthetase 0.0012 0.001 0.0015
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0046 0.0046
Trypanosoma brucei trypanothione reductase 0.0033 0.0256 0.7604
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0028 0.0202 0.0202
Trichomonas vaginalis esterase, putative 0.004 0.0336 0.0332
Schistosoma mansoni nuclear receptor 0.0013 0.0028 0.0028
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.003 0.0223 0.0218
Toxoplasma gondii deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.0864 1 1
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0012 0.001 0.0289
Mycobacterium leprae conserved hypothetical protein 0.004 0.0336 0.0967
Schistosoma mansoni hypothetical protein 0.0058 0.0547 0.0547
Entamoeba histolytica acyl-CoA synthetase, putative 0.004 0.0342 0.0332
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0012 0.001 0.0289
Loa Loa (eye worm) hypothetical protein 0.004 0.0336 0.0336
Giardia lamblia NADH oxidase lateral transfer candidate 0.0011 0.0005 0.5
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0336 0.0336
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0011 0.0005 0.0142
Mycobacterium ulcerans fatty-acid-CoA ligase 0.004 0.0342 0.0996
Loa Loa (eye worm) hypothetical protein 0.0027 0.0184 0.0184
Echinococcus multilocularis musashi 0.0019 0.0091 0.0091
Mycobacterium ulcerans acyl-CoA synthetase 0.0012 0.001 0.0015
Loa Loa (eye worm) hypothetical protein 0.003 0.0223 0.0223
Loa Loa (eye worm) hypothetical protein 0.003 0.0223 0.0223
Plasmodium falciparum deoxyuridine 5'-triphosphate nucleotidohydrolase 0.0864 1 1
Brugia malayi beta-lactamase family protein 0.004 0.0336 0.0336
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0011 0.0005 0.0142
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0011 0.0005 0.0139
Entamoeba histolytica deoxycytidine triphosphate deaminase, putative 0.03 0.3388 0.3382
Mycobacterium tuberculosis Probable dehydrogenase 0.0075 0.0748 0.2206
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0012 0.001 0.0289
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0407 0.0407
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0012 0.001 0.001
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, putative 0.03 0.3388 0.3382
Echinococcus granulosus lamin dm0 0.0019 0.0091 0.0091
Brugia malayi hypothetical protein 0.0015 0.0046 0.0046
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0028 0.0202 0.0202
Brugia malayi ecdysteroid receptor 0.0028 0.0202 0.0202
Brugia malayi Intermediate filament tail domain containing protein 0.0019 0.0091 0.0091
Trichomonas vaginalis deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.0864 1 1
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0336 0.0992
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0202 0.0202
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0336 0.0992
Loa Loa (eye worm) hypothetical protein 0.0028 0.0202 0.0202
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0015 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.001
Schistosoma mansoni nuclear receptor nhr-48 0.0013 0.0028 0.0028
Loa Loa (eye worm) oxidoreductase 0.0012 0.001 0.001
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0083 0.0845 0.2495
Loa Loa (eye worm) nuclear hormone receptor 0.0013 0.0028 0.0028
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0013 0.0028 0.021
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0011 0.0005 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0028 0.0202 0.0202
Loa Loa (eye worm) hypothetical protein 0.0015 0.0046 0.0046
Brugia malayi AMP-binding enzyme family protein 0.0012 0.001 0.001
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0028 0.0202 0.0202
Brugia malayi Nuclear hormone receptor E75 0.0013 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0028 0.0202 0.0202
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0028 0.0202 0.0202
Brugia malayi nuclear receptor NHR-88 0.0013 0.0028 0.0028
Schistosoma mansoni patched 1 0.0071 0.0709 0.0709
Mycobacterium ulcerans deoxyuridine 5'-triphosphate nucleotidohydrolase 0.03 0.3388 1
Schistosoma mansoni nuclear hormone receptor 0.0028 0.0202 0.0202
Schistosoma mansoni zinc finger protein 0.0013 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.003 0.0223 0.0223
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0011 0.0005 0.0139
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0336 0.0336
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0015 0.0046 0.0046
Echinococcus granulosus Nuclear hormone receptor HR96 0.0013 0.0028 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0202 0.0202
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0083 0.0845 0.2495
Brugia malayi nuclear hormone receptor family member odr-7 0.0013 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0034 0.0273 0.0273
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0028 0.0202 0.0202
Echinococcus multilocularis Niemann Pick C1 protein 0.0238 0.2661 0.2661
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0202 0.0202
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0011 0.0005 0.0142
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0013 0.0028 0.0028
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0336 1
Plasmodium vivax thioredoxin reductase, putative 0.0033 0.0256 0.0256
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0084 0.086 0.086
Schistosoma mansoni cellular tumor antigen P53 0.0034 0.0273 0.0273
Onchocerca volvulus Huntingtin homolog 0.0085 0.0867 1
Treponema pallidum deoxyuridine 5'-triphosphate nucleotidohydrolase (dut) 0.0864 1 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0028 0.0202 0.0202
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0864 1 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0028 0.0202 0.0202
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0028
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0202 0.0202
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0864 1 1
Schistosoma mansoni retinoic acid receptor RXR 0.0028 0.0202 0.0202
Loa Loa (eye worm) hypothetical protein 0.004 0.0342 0.0342
Schistosoma mansoni hypothetical protein 0.0069 0.0679 0.0679
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0075 0.0748 0.2206
Echinococcus multilocularis tumor protein p63 0.0234 0.2616 0.2616
Loa Loa (eye worm) transcription factor SMAD2 0.0083 0.0841 0.0841
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0012 0.001 0.0029
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0028
Mycobacterium tuberculosis Conserved protein 0.004 0.0336 0.0992
Onchocerca volvulus 0.0034 0.0273 0.3077
Entamoeba histolytica hypothetical protein 0.0564 0.6484 0.648
Echinococcus granulosus FTZ F1 alpha 0.0028 0.0202 0.0202
Loa Loa (eye worm) DR-78 0.0013 0.0028 0.0028
Mycobacterium ulcerans beta-lactamase 0.004 0.0336 0.098
Mycobacterium ulcerans acyl-CoA synthetase 0.004 0.0342 0.0996
Brugia malayi nuclear hormone receptor 0.0028 0.0202 0.0202
Schistosoma mansoni hypothetical protein 0.0027 0.0184 0.0184
Onchocerca volvulus 0.004 0.0336 0.3811
Loa Loa (eye worm) hypothetical protein 0.0028 0.0202 0.0202
Brugia malayi AMP-binding enzyme family protein 0.0012 0.001 0.001
Trichomonas vaginalis antibiotic synthetase, putative 0.0012 0.001 0.0005
Echinococcus multilocularis lamin dm0 0.0019 0.0091 0.0091
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0028 0.0202 0.0202
Echinococcus granulosus ecdysone induced protein 78C 0.0028 0.0202 0.0202
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0028 0.0202 0.0202
Loa Loa (eye worm) dUTP diphosphatase 0.0864 1 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0336 0.0336
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0033 0.0256 0.0755
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0336 0.098
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.004 0.0342 0.1009
Brugia malayi AMP-binding enzyme family protein 0.004 0.0342 0.0342
Brugia malayi intermediate filament protein 0.0019 0.0091 0.0091
Toxoplasma gondii ABC1 family protein 0.004 0.0336 0.0336
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0013 0.0028 0.0028
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0336 0.0992
Loa Loa (eye worm) nuclear receptor NHR-67 0.0013 0.0028 0.0028
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0012 0.001 0.0029
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0011 0.0005 0.0142
Schistosoma mansoni acetyl-CoA synthetase 0.0012 0.001 0.001
Echinococcus multilocularis sterol regulatory element binding protein 0.0071 0.0709 0.0709
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0028
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0012 0.001 0.0015
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0028 0.0202 0.0202
Echinococcus granulosus lamin 0.0019 0.0091 0.0091
Schistosoma mansoni hypothetical protein 0.0287 0.3231 0.3231
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0204 0.0601
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0011 0.0005 0.0014
Schistosoma mansoni hypothetical protein 0.0033 0.0263 0.0263
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0027 0.0184 0.0184
Brugia malayi AMP-binding enzyme family protein 0.0012 0.001 0.001
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0012 0.001 0.0015
Loa Loa (eye worm) hypothetical protein 0.0071 0.0709 0.0709
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0011 0.0005 0.0142
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0012 0.001 0.0029
Schistosoma mansoni RAR-like nuclear receptor 0.0028 0.0202 0.0202
Echinococcus multilocularis protein dispatched 1 0.0082 0.0828 0.0828
Schistosoma mansoni lamin 0.0019 0.0091 0.0091
Echinococcus multilocularis dUTP pyrophosphatase 0.0864 1 1
Brugia malayi Steroid receptor seven-up type 2 0.0028 0.0202 0.0202
Loa Loa (eye worm) hypothetical protein 0.0015 0.0046 0.0046
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0407 0.0407
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0336 0.0992
Schistosoma mansoni thyroid hormone receptor 0.0028 0.0202 0.0202
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0012 0.001 0.0289
Loa Loa (eye worm) hypothetical protein 0.0028 0.0202 0.0202
Echinococcus multilocularis survival motor neuron protein 1 0.0164 0.1792 0.1792
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0011 0.0005 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0028 0.0202 0.0202
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0011 0.0005 0.0142
Mycobacterium ulcerans acyl-CoA synthetase 0.0012 0.001 0.0015
Mycobacterium tuberculosis Probable oxidoreductase 0.0083 0.0845 0.2495
Brugia malayi beta-lactamase family protein 0.004 0.0336 0.0336
Leishmania major 4-coumarate:coa ligase-like protein 0.004 0.0342 1
Schistosoma mansoni nuclear receptor 0.0013 0.0028 0.0028
Entamoeba histolytica hypothetical protein 0.0864 1 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.0088 0.0898 0.0898
Onchocerca volvulus Bile acid receptor homolog 0.0028 0.0202 0.225
Brugia malayi ecdysone receptor 0.0013 0.0028 0.0028
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0011 0.0005 0.0005
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0204 0.0601
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0013 0.0028 0.0028
Chlamydia trachomatis deoxyuridine 5'-triphosphate nucleotidohydrolase 0.0864 1 1
Brugia malayi nuclear receptor RXR 0.0013 0.0028 0.0028
Echinococcus granulosus Niemann Pick C1 protein 0.0238 0.2661 0.2661
Loa Loa (eye worm) hypothetical protein 0.0166 0.1823 0.1823
Trichomonas vaginalis antibiotic synthetase, putative 0.0012 0.001 0.0005
Leishmania major 4-coumarate:coa ligase-like protein 0.004 0.0342 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0033 0.0256 0.0256
Loa Loa (eye worm) MH2 domain-containing protein 0.0083 0.0841 0.0841
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0028 0.0202 0.0202
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0028
Plasmodium vivax glutathione reductase, putative 0.0033 0.0256 0.0256
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0013 0.0028 0.0028
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0407 0.0407
Brugia malayi AMP-binding enzyme family protein 0.004 0.0342 0.0342
Onchocerca volvulus 0.0019 0.0091 0.0945
Onchocerca volvulus 0.004 0.0336 0.3811
Leishmania major trypanothione reductase 0.0033 0.0256 0.7482
Leishmania major acetyl-CoA synthetase, putative 0.0012 0.001 0.0284
Loa Loa (eye worm) hypothetical protein 0.004 0.0336 0.0336
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0336 1
Echinococcus granulosus GPCR family 2 0.0027 0.0184 0.0184
Loa Loa (eye worm) hypothetical protein 0.0019 0.0091 0.0091
Plasmodium falciparum thioredoxin reductase 0.0011 0.0005 0.0005
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0013 0.0028 0.0028
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.003 0.0223 0.0658
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0012 0.001 0.0015
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0011 0.0005 0.0139
Loa Loa (eye worm) hypothetical protein 0.0028 0.0202 0.0202
Loa Loa (eye worm) hypothetical protein 0.004 0.0336 0.0336
Mycobacterium ulcerans acyl-CoA synthetase 0.0012 0.001 0.0015
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0028
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0336 0.0332
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0202 0.0202
Echinococcus multilocularis thyroid hormone receptor alpha 0.0028 0.0202 0.0202
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0011 0.0005 0.0005
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0253 0.284 0.8381
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0028 0.0202 0.0202
Echinococcus multilocularis Niemann Pick C1 protein 0.0166 0.1823 0.1823
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0407 0.0407
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0012 0.001 0.0029
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0336 0.0336
Echinococcus granulosus thioredoxin glutathione reductase 0.0033 0.0256 0.0256
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0407 0.0407
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0336 0.0992
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0012 0.001 0.0015
Schistosoma mansoni survival motor neuron protein 0.0033 0.0263 0.0263
Echinococcus granulosus survival motor neuron protein 1 0.0164 0.1792 0.1792
Loa Loa (eye worm) hypothetical protein 0.0085 0.0867 0.0867
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0202 0.0202
Loa Loa (eye worm) latrophilin receptor protein 2 0.0027 0.0184 0.0184
Echinococcus multilocularis geminin 0.0287 0.3231 0.3231
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0336 0.0992
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0709 0.0705
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0015 0.0046 0.0046
Leishmania major acetyl-CoA synthetase, putative 0.0012 0.001 0.0284
Leishmania major 4-coumarate:coa ligase-like protein 0.004 0.0342 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.001
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0336 0.0336
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0011 0.0005 0.0142
Echinococcus multilocularis ecdysone induced protein 78C 0.0028 0.0202 0.0202
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0019 0.0091 0.0091
Brugia malayi nuclear receptor NHR-88 0.0028 0.0202 0.0202
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0407 0.0407
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0028 0.0202 0.225
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0028 0.0202 0.0202
Schistosoma mansoni hypothetical protein 0.0027 0.0184 0.0184
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0012 0.001 0.0015
Mycobacterium ulcerans acyl-CoA synthetase 0.0012 0.001 0.0015
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0336 0.0332
Loa Loa (eye worm) hypothetical protein 0.003 0.0223 0.0223
Echinococcus granulosus Protein patched homolog 1 0.0071 0.0709 0.0709
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0027 0.0184 0.0184
Brugia malayi hypothetical protein 0.0015 0.0046 0.0046
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0012 0.001 0.0015
Loa Loa (eye worm) hypothetical protein 0.0058 0.0547 0.0547
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0407 0.0407
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0336 1
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0336 0.098
Schistosoma mansoni hypothetical protein 0.0069 0.0679 0.0679
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0012 0.001 0.0029
Brugia malayi nuclear receptor NHR-67 0.0013 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0015 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0164 0.1792 0.1792
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0012 0.001 0.0029
Onchocerca volvulus 0.0019 0.0091 0.0945
Loa Loa (eye worm) hypothetical protein 0.0085 0.0867 0.0867
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0028 0.0202 0.0202
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.004 0.0342 0.0983
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0028 0.0202 0.0202
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0028 0.0202 0.0202
Onchocerca volvulus 0.0028 0.0202 0.225
Echinococcus granulosus geminin 0.0287 0.3231 0.3231
Schistosoma mansoni deoxyuridine 5'-triphosphate nucleotidohydrolase 0.0864 1 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0015 0.0046 0.0046
Brugia malayi steroid hormone receptor 0.0028 0.0202 0.0202
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0202 0.0202
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0075 0.0748 0.2184
Echinococcus granulosus Niemann Pick C1 protein 0.0166 0.1823 0.1823
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0012 0.001 0.001
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0027 0.0184 0.0184
Brugia malayi AMP-binding enzyme family protein 0.0012 0.001 0.001
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.004 0.0342 0.0996
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0028
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0166 0.1823 0.1816
Mycobacterium tuberculosis Conserved protein 0.004 0.0336 0.0992
Schistosoma mansoni intermediate filament proteins 0.0019 0.0091 0.0091
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.004 0.0342 0.0983
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0336 0.0332
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0012 0.001 0.0029
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0013 0.0028 0.0028
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0028 0.0202 0.0202
Brugia malayi nuclear hormone receptor family member nhr-6 0.0013 0.0028 0.0028
Mycobacterium ulcerans acyl-CoA synthetase 0.0012 0.001 0.0015
Onchocerca volvulus Protein ultraspiracle homolog 0.0028 0.0202 0.225
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.004 0.0342 0.1009
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0012 0.001 0.0289
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0012 0.001 0.0289
Echinococcus granulosus thyroid hormone receptor alpha 0.0013 0.0028 0.0028
Brugia malayi Calcitonin receptor-like protein seb-1 0.0084 0.086 0.086
Loa Loa (eye worm) hypothetical protein 0.0028 0.0202 0.0202
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0028
Brugia malayi hypothetical protein 0.0085 0.0867 0.0867
Mycobacterium ulcerans lipase LipD 0.004 0.0336 0.098
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0012 0.001 0.0029
Trypanosoma cruzi trypanothione reductase, putative 0.0033 0.0256 0.7604
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0013 0.0028 0.0028
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative 0.0864 1 1
Brugia malayi MH2 domain containing protein 0.0083 0.0841 0.0841
Mycobacterium leprae Probable lipase LipE 0.004 0.0336 0.0967
Mycobacterium ulcerans hypothetical protein 0.004 0.0342 0.0996
Brugia malayi tailless protein 0.0013 0.0028 0.0028
Mycobacterium leprae PROBABLE DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE DCD (DCTP DEAMINASE) 0.03 0.3388 1
Brugia malayi Latrophilin receptor protein 2 0.0027 0.0184 0.0184
Brugia malayi beta-lactamase 0.004 0.0336 0.0336
Echinococcus multilocularis FTZ F1 alpha 0.0028 0.0202 0.0202
Schistosoma mansoni thyroid hormone receptor 0.0028 0.0202 0.0202
Onchocerca volvulus 0.004 0.0336 0.3811
Echinococcus granulosus Nuclear hormone receptor HR96 0.0013 0.0028 0.0028
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0046 0.0046
Entamoeba histolytica acyl-coA synthetase, putative 0.004 0.0342 0.0332
Loa Loa (eye worm) thioredoxin reductase 0.0033 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0028
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0011 0.0005 0.0005
Loa Loa (eye worm) steroid hormone receptor 0.0028 0.0202 0.0202
Brugia malayi Thioredoxin reductase 0.0033 0.0256 0.0256
Mycobacterium ulcerans acyl-CoA synthetase 0.0012 0.001 0.0015
Mycobacterium tuberculosis Probable reductase 0.0075 0.0748 0.2206
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0169 0.1854 0.1854
Brugia malayi glutathione reductase 0.0033 0.0256 0.0256
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0028 0.0202 0.0202
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0202 0.0202
Schistosoma mansoni coup transcription factor 0.0028 0.0202 0.0202
Onchocerca volvulus 0.004 0.0342 0.3875
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0012 0.001 0.0284
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0336 0.0332

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.749 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.719 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.713 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.709 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.683 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.667 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.58 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.395 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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