Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Methyltransferase like 2 | 0.0646 | 0.1528 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0135 | 0.0263 | 0.0042 |
Schistosoma mansoni | acyl carrier protein | 0.0217 | 0.0464 | 0.3037 |
Mycobacterium ulcerans | non-ribosomal peptide synthetase | 0.0217 | 0.0464 | 0.0271 |
Chlamydia trachomatis | 3-oxoacyl-ACP synthase | 0.0538 | 0.1261 | 1 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0674 | 0.1597 | 0.1759 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0217 | 0.0464 | 1 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.3205 | 0.787 | 1 |
Leishmania major | beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative | 0.0538 | 0.1261 | 0.7899 |
Schistosoma mansoni | [ACP] S-malonyltransferase | 0.0135 | 0.0263 | 0.1719 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0217 | 0.0464 | 0.0302 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.2003 | 0.4892 | 0.6089 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.2003 | 0.4892 | 0.5439 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0257 | 0.0103 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.1725 | 0.4203 | 0.5183 |
Loa Loa (eye worm) | acyl carrier protein | 0.0217 | 0.0464 | 0.0341 |
Toxoplasma gondii | acyl carrier protein ACP | 0.0217 | 0.0464 | 0.0737 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.1418 | 0.3441 | 0.4183 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0217 | 0.0464 | 0.0271 |
Loa Loa (eye worm) | acyl carrier protein | 0.0986 | 0.2371 | 0.2536 |
Mycobacterium leprae | Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) | 0.0217 | 0.0464 | 0.0271 |
Loa Loa (eye worm) | fatty acid synthase | 0.2116 | 0.5171 | 0.5759 |
Trypanosoma cruzi | acyl transferase-like protein, putative | 0.0135 | 0.0263 | 0.0053 |
Mycobacterium ulcerans | acyl carrier protein | 0.0217 | 0.0464 | 0.0271 |
Loa Loa (eye worm) | hypothetical protein | 0.0329 | 0.0742 | 0.0662 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.3865 | 0.9507 | 1 |
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | 0.0217 | 0.0464 | 0.0271 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0304 | 0.0681 | 0.5398 |
Loa Loa (eye worm) | phosphopantetheine attachment site family protein | 0.0217 | 0.0464 | 0.0341 |
Onchocerca volvulus | 0.3732 | 0.9177 | 0.9648 | |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0257 | 0.0103 |
Toxoplasma gondii | acyl transferase domain-containing protein | 0.0135 | 0.0263 | 0.0372 |
Plasmodium vivax | hypothetical protein, conserved | 0.0307 | 0.0689 | 0.4269 |
Echinococcus granulosus | Malonyl coenzyme A acyl carrier protein transacylase | 0.0135 | 0.0263 | 0.2083 |
Mycobacterium tuberculosis | Probable polyketide beta-ketoacyl synthase Pks3 | 0.0329 | 0.0742 | 0.0637 |
Mycobacterium ulcerans | fatty-acid-CoA ligase FadD9 | 0.0217 | 0.0464 | 0.0271 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0217 | 0.0464 | 0.0271 |
Onchocerca volvulus | 0.0217 | 0.0464 | 0.0349 | |
Plasmodium vivax | 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative | 0.0538 | 0.1261 | 1 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.1084 | 0.2613 | 0.4634 |
Brugia malayi | Methyltransferase-like protein 4 | 0.0646 | 0.1528 | 0.1384 |
Mycobacterium tuberculosis | Probable polyketide beta-ketoacyl synthase Pks4 | 0.0329 | 0.0742 | 0.0637 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.3205 | 0.787 | 1 |
Trypanosoma cruzi | beta-ketoacyl synthase family protein, putative | 0.0538 | 0.1261 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0646 | 0.1528 | 0.1669 |
Trypanosoma brucei | beta-ketoacyl-ACP synthase | 0.0538 | 0.1261 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.0263 | 0.011 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0307 | 0.0689 | 0.4269 |
Onchocerca volvulus | 0.0097 | 0.0167 | 0.0032 | |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.2278 | 0.5572 | 0.6981 |
Mycobacterium ulcerans | non-ribosomal peptide synthetase MbtF | 0.0217 | 0.0464 | 0.0271 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.2144 | 0.5242 | 0.6547 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.3205 | 0.787 | 1 |
Mycobacterium ulcerans | non-ribosomal peptide synthetase MbtE | 0.0217 | 0.0464 | 0.0271 |
Mycobacterium tuberculosis | Peptide synthetase MbtF (peptide synthase) | 0.0217 | 0.0464 | 0.0271 |
Mycobacterium ulcerans | 3-oxoacyl-(acyl carrier protein) synthase II | 0.0538 | 0.1261 | 0.1319 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0217 | 0.0464 | 0.0271 |
Mycobacterium tuberculosis | Probable acyl carrier protein AcpA (ACP) | 0.0217 | 0.0464 | 0.0271 |
Wolbachia endosymbiont of Brugia malayi | ACP S-malonyltransferase | 0.0135 | 0.0263 | 0.0053 |
Plasmodium falciparum | 3-oxoacyl-acyl-carrier protein synthase I/II | 0.0538 | 0.1261 | 1 |
Wolbachia endosymbiont of Brugia malayi | acyl carrier protein | 0.0217 | 0.0464 | 0.2059 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.1787 | 0.4356 | 0.5384 |
Mycobacterium ulcerans | thioesterase TesA | 0.1787 | 0.4356 | 0.5384 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.3205 | 0.787 | 1 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.2144 | 0.5242 | 0.6547 |
Mycobacterium tuberculosis | Polyketide synthetase MbtD (polyketide synthase) | 0.0659 | 0.1561 | 0.1713 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.1725 | 0.4203 | 0.5183 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.2079 | 0.5079 | 0.6333 |
Echinococcus multilocularis | Acyl carrier protein, mitochondrial | 0.0217 | 0.0464 | 0.368 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.2144 | 0.5242 | 0.6547 |
Onchocerca volvulus | 0.0133 | 0.0257 | 0.0128 | |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.2144 | 0.5242 | 0.6547 |
Mycobacterium ulcerans | polyketide synthase MbtD | 0.0659 | 0.1561 | 0.1713 |
Brugia malayi | Phosphopantetheine attachment site family protein | 0.0217 | 0.0464 | 0.0302 |
Brugia malayi | Alcohol dehydrogenase class III | 0.0133 | 0.0257 | 0.0091 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.2144 | 0.5242 | 0.5161 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0674 | 0.1597 | 0.1759 |
Brugia malayi | acyl carrier protein, mitochondrial precursor, putative | 0.0217 | 0.0464 | 0.0302 |
Echinococcus multilocularis | mitochondrial trans 2 enoyl coenzyme A reductase | 0.0133 | 0.0257 | 0.2041 |
Mycobacterium ulcerans | polyketide synthase | 0.2278 | 0.5572 | 0.6981 |
Echinococcus multilocularis | 3 oxoacyl (acyl carrier protein) synthase | 0.0538 | 0.1261 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.1418 | 0.3441 | 0.4183 |
Toxoplasma gondii | type I fatty acid synthase | 0.0329 | 0.0742 | 0.1242 |
Treponema pallidum | acyl carrier protein | 0.0217 | 0.0464 | 0.5 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.2278 | 0.5572 | 0.6981 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein synthase | 0.0538 | 0.1261 | 1 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0538 | 0.1261 | 1 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.2278 | 0.5572 | 0.6981 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.1754 | 0.4273 | 0.5275 |
Mycobacterium ulcerans | polyketide synthase MbtC | 0.0538 | 0.1261 | 0.1319 |
Echinococcus multilocularis | Malonyl coenzyme A acyl carrier protein transacylase | 0.0135 | 0.0263 | 0.2083 |
Echinococcus multilocularis | NADH dehydrogenase | 0.0217 | 0.0464 | 0.368 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.2278 | 0.5572 | 0.6981 |
Mycobacterium leprae | PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) | 0.0674 | 0.1597 | 0.1759 |
Mycobacterium ulcerans | acyl carrier protein | 0.0217 | 0.0464 | 0.0271 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0867 | 0.2076 | 0.2389 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.2079 | 0.5079 | 0.6333 |
Onchocerca volvulus | Acyl carrier protein, mitochondrial homolog | 0.0217 | 0.0464 | 0.0349 |
Loa Loa (eye worm) | beta-ketoacyl synthase domain-containing protein | 0.0538 | 0.1261 | 0.1259 |
Leishmania major | acyl carrier protein, putative | 0.0217 | 0.0464 | 0.1626 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0097 | 0.0167 | 0.1096 |
Trypanosoma cruzi | Acyl carrier protein, mitochondrial, putative | 0.0217 | 0.0464 | 0.2059 |
Brugia malayi | ADP-specific Phosphofructokinase/Glucokinase conserved region family protein | 0.0135 | 0.0263 | 0.0097 |
Chlamydia trachomatis | acyl carrier protein | 0.0217 | 0.0464 | 0.2016 |
Toxoplasma gondii | 3-oxoacyl-acyl-carrier protein synthase I/II, putative | 0.0538 | 0.1261 | 0.2183 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.2278 | 0.5572 | 1 |
Schistosoma mansoni | [ACP] S-malonyltransferase | 0.0135 | 0.0263 | 0.1719 |
Mycobacterium leprae | Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0217 | 0.0464 | 0.0271 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0257 | 0.0103 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0646 | 0.1528 | 0.1669 |
Trypanosoma brucei | Acyl carrier protein, mitochondrial | 0.0217 | 0.0464 | 0.2059 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0646 | 0.1528 | 1 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.1787 | 0.4356 | 0.5384 |
Trypanosoma brucei | acyl transferase-like protein | 0.0135 | 0.0263 | 0.0053 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0395 | 0.0907 | 0.7194 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0097 | 0.0167 | 0.1096 |
Mycobacterium tuberculosis | Acyl carrier protein (ACP) MbtL | 0.0217 | 0.0464 | 0.0271 |
Leishmania major | hypothetical protein, conserved | 0.0646 | 0.1528 | 1 |
Loa Loa (eye worm) | alcohol dehydrogenase class III | 0.0133 | 0.0257 | 0.0103 |
Mycobacterium tuberculosis | Meromycolate extension acyl carrier protein AcpM | 0.0217 | 0.0464 | 0.0271 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0329 | 0.0742 | 0.0637 |
Schistosoma mansoni | hypothetical protein | 0.0395 | 0.0907 | 0.5937 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.1418 | 0.3441 | 0.4183 |
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | 0.0217 | 0.0464 | 0.0271 |
Trypanosoma cruzi | beta-ketoacyl synthase family protein, putative | 0.0538 | 0.1261 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0257 | 0.0103 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0217 | 0.0464 | 1 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0133 | 0.0257 | 0.0091 |
Mycobacterium tuberculosis | Probable peptide synthetase Nrp (peptide synthase) | 0.0217 | 0.0464 | 0.0271 |
Echinococcus granulosus | acyl carrier protein mitochondrial | 0.0217 | 0.0464 | 0.368 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.154 | 0.3745 | 0.4581 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0737 | 0.1754 | 0.1966 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0133 | 0.0257 | 0.0091 |
Echinococcus granulosus | AMP dependent ligase | 0.0217 | 0.0464 | 0.368 |
Toxoplasma gondii | quinone oxidoreductase, putative | 0.0133 | 0.0257 | 0.0362 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.2144 | 0.5242 | 0.6547 |
Loa Loa (eye worm) | hypothetical protein | 0.0329 | 0.0742 | 0.0662 |
Schistosoma mansoni | zinc binding dehydrogenase | 0.0133 | 0.0257 | 0.1684 |
Schistosoma mansoni | 3-oxoacyl-[ACP] synthase | 0.0538 | 0.1261 | 0.8253 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.2144 | 0.5242 | 0.6547 |
Echinococcus granulosus | NADH dehydrogenase | 0.0217 | 0.0464 | 0.368 |
Toxoplasma gondii | Zn-containing alcohol dehydrogenase | 0.0133 | 0.0257 | 0.0362 |
Schistosoma mansoni | hypothetical protein | 0.0217 | 0.0464 | 0.3037 |
Echinococcus multilocularis | AMP dependent ligase | 0.0217 | 0.0464 | 0.368 |
Schistosoma mansoni | methyltransferase-related | 0.0646 | 0.1528 | 1 |
Schistosoma mansoni | [ACP] S-malonyltransferase | 0.0135 | 0.0263 | 0.1719 |
Onchocerca volvulus | 0.2003 | 0.4892 | 0.5075 | |
Mycobacterium ulcerans | peptide synthetase Nrp (peptide synthase) | 0.0217 | 0.0464 | 0.0271 |
Brugia malayi | AMP-binding enzyme family protein | 0.2003 | 0.4892 | 0.4805 |
Mycobacterium leprae | conserved hypothetical protein | 0.0217 | 0.0464 | 0.0271 |
Brugia malayi | MH2 domain containing protein | 0.0115 | 0.0213 | 0.0047 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.2144 | 0.5242 | 0.6547 |
Mycobacterium ulcerans | hypothetical protein | 0.0217 | 0.0464 | 0.0271 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.1725 | 0.4203 | 0.5183 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.2278 | 0.5572 | 0.6981 |
Mycobacterium ulcerans | malonyl CoA-acyl carrier protein transacylase FabD | 0.0135 | 0.0263 | 0.0007 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0115 | 0.0213 | 0.0053 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.2278 | 0.5572 | 0.6981 |
Echinococcus granulosus | dnaJ subfamily B | 0.0395 | 0.0907 | 0.7194 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.2278 | 0.5572 | 0.6981 |
Loa Loa (eye worm) | hypothetical protein | 0.3602 | 0.8855 | 1 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0329 | 0.0742 | 0.0637 |
Mycobacterium ulcerans | phenyloxazoline synthase MbtB | 0.0217 | 0.0464 | 0.0271 |
Mycobacterium ulcerans | 3-oxoacyl-(acyl carrier protein) synthase II | 0.0538 | 0.1261 | 0.1319 |
Mycobacterium ulcerans | polyketide synthase | 0.2144 | 0.5242 | 0.6547 |
Loa Loa (eye worm) | hypothetical protein | 0.1201 | 0.2905 | 0.3151 |
Brugia malayi | AMP-binding enzyme family protein | 0.0659 | 0.1561 | 0.1417 |
Onchocerca volvulus | 0.0133 | 0.0257 | 0.0128 | |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0304 | 0.0681 | 0.5398 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks17 | 0.0524 | 0.1226 | 0.1272 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0133 | 0.0257 | 0.0091 |
Trypanosoma cruzi | acyl transferase-like protein | 0.0135 | 0.0263 | 0.0053 |
Mycobacterium leprae | PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 | 0.0329 | 0.0742 | 0.0637 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.1526 | 0.371 | 0.6624 |
Plasmodium vivax | acyl carrier protein, putative | 0.0217 | 0.0464 | 0.2016 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0059 | 0.0073 | 0.0479 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0115 | 0.0213 | 0.0053 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.1391 | 0.3375 | 0.6016 |
Onchocerca volvulus | Putative alcohol dehydrogenase | 0.0133 | 0.0257 | 0.0128 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.2144 | 0.5242 | 0.6547 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0538 | 0.1261 | 0.1112 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.2144 | 0.5242 | 0.6547 |
Schistosoma mansoni | alcohol dehydrogenase | 0.0133 | 0.0257 | 0.1684 |
Plasmodium falciparum | acyl carrier protein | 0.0217 | 0.0464 | 0.2016 |
Mycobacterium ulcerans | thioesterase | 0.1787 | 0.4356 | 0.5384 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.1219 | 0.2948 | 0.3535 |
Echinococcus granulosus | mitochondrial trans 2 enoyl coenzyme A reductase | 0.0133 | 0.0257 | 0.2041 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.2278 | 0.5572 | 0.6981 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.074 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.073 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.