TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 464.354 | Formula: C24H22BrN3O2
H donors: 2 H acceptors: 3 LogP: 5.72 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Cc1cccc(c1)Cc1n[nH]c2c1cc(c(c2)O)C(=O)N(Cc1ccccc1Br)C
InChi: 1S/C24H22BrN3O2/c1-15-6-5-7-16(10-15)11-21-18-12-19(23(29)13-22(18)27-26-21)24(30)28(2)14-17-8-3-4-9-20(17)25/h3-10,12-13,29H,11,14H2,1-2H3,(H,26,27)
InChiKey: JEQKKBLDCUBLCH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	heat shock protein 90kDa alpha (cytosolic), class B member 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania braziliensis	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Mycobacterium ulcerans	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma congolense	Heat shock protein 83, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Echinococcus granulosus	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Giardia lamblia	Grp94/Hsp90	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei gambiense	Heat shock protein 83, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Candida albicans	heat shock protein	Get druggable targets OG5_126623	All targets in OG5_126623
Cryptosporidium parvum	Hsp90	Get druggable targets OG5_126623	All targets in OG5_126623
Brugia malayi	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei gambiense	Heat shock protein 83, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Candida albicans	heat shock protein	Get druggable targets OG5_126623	All targets in OG5_126623
Neospora caninum	HSP90, related	Get druggable targets OG5_126623	All targets in OG5_126623
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Babesia bovis	hsp90 protein	Get druggable targets OG5_126623	All targets in OG5_126623
Schistosoma mansoni	endoplasmin	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania braziliensis	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Cryptosporidium hominis	heat shock protein 83	Get druggable targets OG5_126623	All targets in OG5_126623
Brugia malayi	Endoplasmin precursor	Get druggable targets OG5_126623	All targets in OG5_126623
Echinococcus multilocularis	heat shock protein	Get druggable targets OG5_126623	All targets in OG5_126623
Plasmodium knowlesi	endoplasmin, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Giardia lamblia	Heat shock protein HSP 90-alpha	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania donovani	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Loa Loa (eye worm)	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Candida albicans	hypothetical protein	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Schistosoma mansoni	heat shock protein	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma congolense	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Toxoplasma gondii	heat shock protein HSP90	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania infantum	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Mycobacterium leprae	PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G)	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma cruzi	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Theileria parva	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Schistosoma japonicum	Heat shock protein 83, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Entamoeba histolytica	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma cruzi	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Schistosoma japonicum	ko:K04079 molecular chaperone HtpG, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Plasmodium vivax	endoplasmin, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma cruzi	heat shock protein 85, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Echinococcus multilocularis	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Plasmodium berghei	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma cruzi	heat shock protein 85, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania mexicana	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Schistosoma mansoni	endoplasmin	Get druggable targets OG5_126623	All targets in OG5_126623
Schistosoma japonicum	Heat shock protein HSP 90-alpha, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Plasmodium yoelii	heat shock 90 kDa protein homolog	Get druggable targets OG5_126623	All targets in OG5_126623
Plasmodium knowlesi	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Schistosoma japonicum	IPR003367,Thrombospondin type 3 repeat;IPR002048,Calcium-binding EF-hand,domain-containing	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei gambiense	heat shock protein 83,heat shock protein	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma cruzi	heat shock protein 85, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Schistosoma japonicum	Heat shock protein HSP 90-beta, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei gambiense	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania infantum	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Echinococcus granulosus	heat shock protein	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Schistosoma mansoni	heat shock protein	Get druggable targets OG5_126623	All targets in OG5_126623
Giardia lamblia	Heat shock protein HSP 90-alpha	Get druggable targets OG5_126623	All targets in OG5_126623
Toxoplasma gondii	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania infantum	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania donovani	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Plasmodium yoelii	putative heat shock protein 81-2	Get druggable targets OG5_126623	All targets in OG5_126623
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Treponema pallidum	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Neospora caninum	HSP90-like protein, related	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma cruzi	heat shock protein 85, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	Heat shock protein 83, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Mycobacterium tuberculosis	Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G)	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma congolense	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Plasmodium vivax	heat shock protein 86, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Loa Loa (eye worm)	endoplasmin	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Echinococcus multilocularis	endoplasmin	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma cruzi	Heat shock protein 83, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Echinococcus granulosus	endoplasmin	Get druggable targets OG5_126623	All targets in OG5_126623
Plasmodium yoelii	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania infantum	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Schistosoma japonicum	ko:K09487 heat shock protein 90kDa beta, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Echinococcus multilocularis	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania braziliensis	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Plasmodium falciparum	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Echinococcus granulosus	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Wolbachia endosymbiont of Brugia malayi	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania braziliensis	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Entamoeba histolytica	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania mexicana	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma cruzi	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania mexicana	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	Get druggable targets OG5_126623	All targets in OG5_126623

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	heat shock protein 90, putative	heat shock protein 90kDa alpha (cytosolic), class B member 1	724 aa	725 aa	35.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Giardia lamblia	Cathepsin L precursor	0.0044	0.0345	0.1359
Mycobacterium leprae	PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G)	0.0031	0.0211	0.5
Plasmodium falciparum	serine repeat antigen 1	0.0044	0.0345	0.1487
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0202	0.2044	0.2823
Echinococcus granulosus	cathepsin b	0.03	0.3098	0.3449
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0044	0.0345	0.0454
Echinococcus multilocularis	cysteine protease	0.0202	0.2044	0.2022
Brugia malayi	Papain family cysteine protease containing protein	0.0108	0.1034	0.1603
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0202	0.2044	0.2823
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0045	0.0356	0.0524
Entamoeba histolytica	cysteine proteinase, putative	0.0202	0.2044	1
Brugia malayi	Cathepsin L-like precursor	0.0202	0.2044	0.3212
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0202	0.2044	0.2823
Trichomonas vaginalis	set domain proteins, putative	0.0681	0.7193	1
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0345	0.0454
Leishmania major	heat shock protein 83-1	0.0039	0.0297	0.1247
Trypanosoma cruzi	heat shock protein 90, putative	0.0039	0.0297	0.0816
Echinococcus multilocularis	dnaJ subfamily B	0.0843	0.893	0.8927
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0123	0.1196	0.5753
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0051	0.0422	0.0629
Entamoeba histolytica	heat shock protein 90, putative	0.0039	0.0297	0.1247
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0087	0.0809	0.3815
Plasmodium vivax	heat shock protein 86, putative	0.0039	0.0297	0.1247
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0218	0.2222	0.2201
Giardia lamblia	Cathepsin B precursor	0.0123	0.1196	1
Onchocerca volvulus		0.0044	0.0345	0.0416
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.009	0.0838	0.091
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0063	0.0553	0.0619
Loa Loa (eye worm)	endoplasmin	0.0039	0.0297	0.0429
Onchocerca volvulus		0.0138	0.1355	0.183
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0564	0.0855
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0044	0.0345	0.1487
Brugia malayi	cathepsin B-like cysteine proteinase	0.03	0.3098	0.489
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0345	0.0454
Trypanosoma cruzi	cysteine proteinase, putative	0.0108	0.1034	0.3232
Trichomonas vaginalis	CAMK family protein kinase	0.0025	0.0146	0.0177
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0051	0.0422	0.1876
Brugia malayi	cathepsin L-like cysteine proteinase	0.0044	0.0345	0.0506
Trypanosoma cruzi	cruzipain precursor, putative	0.0202	0.2044	0.6545
Entamoeba histolytica	cysteine proteinase, putative	0.0108	0.1034	0.4938
Entamoeba histolytica	cysteine protease, putative	0.0108	0.1034	0.4938
Trichomonas vaginalis	heat shock protein, putative	0.0039	0.0297	0.0387
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0202	0.2044	1
Toxoplasma gondii	heat shock protein 90, putative	0.0039	0.0297	0.1247
Trichomonas vaginalis	CAMK family protein kinase	0.0051	0.0422	0.0562
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0044	0.0345	0.0454
Echinococcus granulosus	heat shock protein	0.0039	0.0297	0.0303
Leishmania major	cathepsin L-like protease	0.0202	0.2044	1
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0018	0.0067	0.004
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0345	0.0454
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0044	0.0345	0.0386
Brugia malayi	cathepsin L-like precursor	0.0138	0.1355	0.2115
Echinococcus granulosus	cysteine protease	0.0108	0.1034	0.113
Onchocerca volvulus		0.0202	0.2044	0.2794
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0021	0.0106	0.0079
Entamoeba histolytica	cysteine protease, putative	0.0108	0.1034	0.4938
Echinococcus granulosus	endoplasmin	0.0031	0.0211	0.0206
Entamoeba histolytica	cysteine proteinase, putative	0.0202	0.2044	1
Entamoeba histolytica	cysteine proteinase 2	0.0108	0.1034	0.4938
Schistosoma mansoni	hypothetical protein	0.0014	0.0027	0.003
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0202	0.2044	0.2823
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0202	0.2044	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0045	0.0356	0.0524
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0044	0.0345	0.0386
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0044	0.0345	0.1487
Plasmodium falciparum	heat shock protein 90	0.0039	0.0297	0.1247
Toxoplasma gondii	heat shock protein HSP90	0.0039	0.0297	0.1247
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0345	0.0506
Schistosoma mansoni	hypothetical protein	0.0014	0.0027	0.003
Trypanosoma cruzi	heat shock protein 90, putative	0.0023	0.0124	0.025
Trypanosoma brucei	heat shock protein, putative	0.0039	0.0297	0.1247
Leishmania major	cathepsin L-like protease	0.0202	0.2044	1
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0044	0.0345	0.1487
Trypanosoma cruzi	cysteine protease, putative	0.0108	0.1034	0.3232
Mycobacterium tuberculosis	Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G)	0.0031	0.0211	0.5
Brugia malayi	Cathepsin L-like precursor	0.0138	0.1355	0.2115
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0087	0.0809	0.0784
Brugia malayi	CXXC zinc finger family protein	0.0059	0.0511	0.077
Leishmania major	heat shock protein 83-1	0.0039	0.0297	0.1247
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0044	0.0345	0.1487
Giardia lamblia	Cathepsin L-like protease	0.0044	0.0345	0.1359
Leishmania major	heat shock protein 83-1	0.0039	0.0297	0.1247
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0471	0.0706
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0044	0.0345	0.1487
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0044	0.0345	0.0386
Trypanosoma cruzi	cysteine peptidase, putative	0.0202	0.2044	0.6545
Loa Loa (eye worm)	ctsf protein	0.0202	0.2044	0.3212
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0138	0.1355	0.4286
Schistosoma mansoni	hypothetical protein	0.0014	0.0027	0.003
Brugia malayi	F/Y-rich N-terminus family protein	0.0021	0.0103	0.0121
Entamoeba histolytica	cysteine protease, putative	0.0044	0.0345	0.1487
Mycobacterium ulcerans	heat shock protein 90	0.0031	0.0211	0.5
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0809	0.1246
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0044	0.0345	0.0454
Plasmodium vivax	serine-repeat antigen (SERA)	0.0044	0.0345	0.1487
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	0.0031	0.0211	0.0817
Leishmania major	heat shock protein 83-1	0.0039	0.0297	0.1247
Brugia malayi	Papain family cysteine protease containing protein	0.0202	0.2044	0.3212
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0345	0.0506
Entamoeba histolytica	cysteine proteinase, putative	0.0108	0.1034	0.4938
Schistosoma mansoni	cpg binding protein	0.0063	0.0547	0.0613
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0202	0.2044	0.2823
Plasmodium falciparum	endoplasmin, putative	0.0024	0.0134	0.043
Loa Loa (eye worm)	fibroinase	0.0202	0.2044	0.3212
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0202	0.2044	1
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0051	0.0422	0.0524
Trypanosoma brucei	heat shock protein, putative	0.0039	0.0297	0.1247
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0044	0.0345	0.0386
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.009	0.0838	0.091
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0018	0.0067	0.0044
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.009	0.0838	0.0813
Trichomonas vaginalis	heat shock protein, putative	0.0031	0.0211	0.0267
Entamoeba histolytica	hypothetical protein	0.0044	0.0345	0.1487
Entamoeba histolytica	cysteine protease, putative	0.0108	0.1034	0.4938
Echinococcus granulosus	polycomb protein SCMH1	0.0055	0.0471	0.0498
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0044	0.0345	0.0506
Giardia lamblia	Cathepsin B precursor	0.0044	0.0345	0.1359
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.03	0.3098	0.3469
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.0838	0.0938
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0202	0.2044	0.2823
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0345	0.0506
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0064	0.0564	0.0855
Brugia malayi	Cathepsin L-like precursor	0.0138	0.1355	0.2115
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0202	0.2044	1
Brugia malayi	Papain family cysteine protease containing protein	0.0044	0.0345	0.0506
Trypanosoma cruzi	major cysteine proteinase, putative	0.0044	0.0345	0.0974
Trypanosoma brucei	heat shock protein 90, putative	0.0039	0.0297	0.1247
Leishmania major	heat shock protein 83-1	0.0039	0.0297	0.1247
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0108	0.1034	0.4938
Schistosoma mansoni	cathepsin B (C01 family)	0.0044	0.0345	0.0386
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0044	0.0345	0.1487
Echinococcus multilocularis	heat shock protein	0.0039	0.0297	0.027
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0044	0.0345	0.1359
Onchocerca volvulus		0.0681	0.7193	1
Giardia lamblia	Cathepsin B precursor	0.0044	0.0345	0.1359
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0202	0.2044	1
Echinococcus granulosus	heat shock protein 90	0.0039	0.0297	0.0303
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0055	0.0471	0.0527
Toxoplasma gondii	cathepsin CPC1	0.0044	0.0345	0.1487
Entamoeba histolytica	cysteine protease, putative	0.0044	0.0345	0.1487
Echinococcus granulosus	heat shock protein 90	0.0031	0.0211	0.0206
Schistosoma mansoni	sex comb on midleg homolog	0.0055	0.0471	0.0527
Plasmodium vivax	SET domain protein, putative	0.0087	0.0809	0.3815
Trypanosoma cruzi	heat shock protein 85, putative	0.0039	0.0297	0.0816
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0044	0.0345	0.0506
Trichomonas vaginalis	CAMK family protein kinase	0.0051	0.0422	0.0562
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.009	0.0838	0.0813
Trichomonas vaginalis	CAMK family protein kinase	0.0051	0.0422	0.0562
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.0838	0.0938
Trichomonas vaginalis	heat shock protein, putative	0.0024	0.0134	0.016
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0345	0.0506
Trichomonas vaginalis	CAMK family protein kinase	0.0025	0.0146	0.0177
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0345	0.0454
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0044	0.0345	0.0454
Brugia malayi	Cathepsin L-like precursor	0.0202	0.2044	0.3212
Echinococcus multilocularis	cathepsin L	0.0044	0.0345	0.0318
Leishmania major	heat shock protein 83-1	0.0039	0.0297	0.1247
Trypanosoma cruzi	polo-like protein kinase, putative	0.0051	0.0422	0.1228
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0123	0.1196	0.3765
Entamoeba histolytica	cysteine protease, putative	0.0202	0.2044	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0044	0.0345	0.0506
Giardia lamblia	Cathepsin L precursor	0.0044	0.0345	0.1359
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0044	0.0345	0.0454
Leishmania major	cathepsin L-like protease	0.0202	0.2044	1
Trypanosoma cruzi	Heat shock protein 83, putative	0.0039	0.0297	0.0816
Leishmania major	heat shock protein 83-1	0.0039	0.0297	0.1247
Leishmania major	cathepsin L-like protease	0.0202	0.2044	1
Plasmodium vivax	vivapain-2	0.0202	0.2044	1
Echinococcus granulosus	histone lysine methyltransferase setb	0.0087	0.0809	0.0879
Echinococcus multilocularis	cpg binding protein	0.0063	0.0547	0.0521
Loa Loa (eye worm)	hypothetical protein	0.0138	0.1355	0.2115
Trichomonas vaginalis	heat shock protein, putative	0.0031	0.0211	0.0267
Onchocerca volvulus	Cathepsin F homolog	0.0202	0.2044	0.2794
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0202	0.2044	0.2022
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.03	0.3098	0.3469
Brugia malayi	cathepsin L precursor	0.0044	0.0345	0.0506
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0123	0.1196	0.5753
Wolbachia endosymbiont of Brugia malayi	heat shock protein 90	0.0031	0.0211	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0345	0.0454
Entamoeba histolytica	cysteine protease, putative	0.0108	0.1034	0.4938
Treponema pallidum	heat shock protein 90	0.0031	0.0211	0.5
Giardia lamblia	Cathepsin L precursor	0.0044	0.0345	0.1359
Schistosoma mansoni	endoplasmin	0.0039	0.0297	0.0332
Trypanosoma brucei	heat shock protein, putative	0.0039	0.0297	0.1247
Trichomonas vaginalis	heat shock protein, putative	0.0016	0.0048	0.004
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.009	0.0838	0.1291
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0018	0.0067	0.0044
Brugia malayi	MH2 domain containing protein	0.0096	0.0906	0.1399
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0051	0.0422	0.0444
Trypanosoma brucei	heat shock protein, putative	0.0039	0.0297	0.1247
Entamoeba histolytica	cysteine proteinase, putative	0.0108	0.1034	0.4938
Loa Loa (eye worm)	heat shock protein 75	0.0016	0.0048	0.0033
Leishmania major	heat shock protein 83-1	0.0039	0.0297	0.1247
Plasmodium falciparum	serine repeat antigen 7	0.0044	0.0345	0.1487
Trypanosoma cruzi	cysteine proteinase, putative	0.0108	0.1034	0.3232
Onchocerca volvulus		0.0202	0.2044	0.2794
Schistosoma mansoni	cathepsin C	0.0044	0.0345	0.0386
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0044	0.0345	0.1359
Entamoeba histolytica	cysteine protease, putative	0.0108	0.1034	0.4938
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0108	0.1034	0.4938
Brugia malayi	Endoplasmin precursor	0.0039	0.0297	0.0429
Onchocerca volvulus		0.0087	0.0809	0.1066
Brugia malayi	Cathepsin L-like precursor	0.0202	0.2044	0.3212
Entamoeba histolytica	cysteine protease, putative	0.0044	0.0345	0.1487
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0044	0.0345	0.0506
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0202	0.2044	1
Trypanosoma cruzi	heat shock protein 85, putative	0.0039	0.0297	0.0816
Plasmodium falciparum	serine repeat antigen 4	0.0044	0.0345	0.1487
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0108	0.1034	0.1157
Giardia lamblia	Cathepsin B precursor	0.0044	0.0345	0.1359
Giardia lamblia	Cathepsin B precursor	0.0123	0.1196	1
Giardia lamblia	Hypothetical protein	0.0044	0.0345	0.1359
Plasmodium falciparum	serine repeat antigen 2	0.0044	0.0345	0.1487
Entamoeba histolytica	heat shock protein 90, putative	0.0039	0.0297	0.1247
Trypanosoma cruzi	cysteine peptidase, putative	0.0064	0.0564	0.1692
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0108	0.1034	0.1414
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0044	0.0345	0.1487
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0051	0.0422	0.0396
Leishmania major	heat shock protein 83-1	0.0039	0.0297	0.1247
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0044	0.0345	0.0454
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0345	0.0454
Toxoplasma gondii	cathepsin CPC2	0.0044	0.0345	0.1487
Entamoeba histolytica	cysteine protease, putative	0.0044	0.0345	0.1487
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0044	0.0345	0.0386
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.03	0.3098	0.3469
Echinococcus multilocularis	cathepsin L cysteine protease	0.0202	0.2044	0.2022
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0202	0.2044	0.3212
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0202	0.2044	0.2823
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0218	0.2222	0.2465
Schistosoma mansoni	sex comb on midleg homolog	0.0055	0.0471	0.0527
Schistosoma mansoni	serine/threonine protein kinase	0.0051	0.0422	0.0473
Loa Loa (eye worm)	hypothetical protein	0.0138	0.1355	0.2115
Leishmania major	heat shock protein 83-1	0.0039	0.0297	0.1247
Schistosoma mansoni	heat shock protein	0.0039	0.0297	0.0332
Plasmodium falciparum	serine repeat antigen 5	0.0044	0.0345	0.1487
Schistosoma mansoni	hypothetical protein	0.0319	0.3302	0.3697
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0202	0.2044	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0018	0.0067	0.0075
Giardia lamblia	Cysteine protease	0.0044	0.0345	0.1359
Entamoeba histolytica	cysteine protease, putative	0.0108	0.1034	0.4938
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0108	0.1034	0.1157
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0055	0.0471	0.0445
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0345	0.0506
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0044	0.0345	0.1487
Leishmania major	heat shock protein 83-1	0.0039	0.0297	0.1247
Echinococcus granulosus	heat shock protein 75 kDa mitochondrial	0.0016	0.0048	0.0023
Brugia malayi	heat shock protein 90	0.0039	0.0297	0.0429
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0138	0.1355	0.2115
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0108	0.1034	0.1157
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0051	0.0422	0.1876
Giardia lamblia	Cathepsin B precursor	0.0123	0.1196	1
Echinococcus multilocularis	heat shock protein 90	0.0031	0.0211	0.0184
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0044	0.0345	0.0386
Schistosoma mansoni	cathepsin S (C01 family)	0.0044	0.0345	0.0386
Plasmodium falciparum	serine repeat antigen 9	0.0044	0.0345	0.1487
Echinococcus granulosus	dnaJ subfamily B	0.0843	0.893	1
Giardia lamblia	Cathepsin L-like protease	0.0044	0.0345	0.1359
Onchocerca volvulus		0.0202	0.2044	0.2794
Schistosoma mansoni	hypothetical protein	0.0843	0.893	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0202	0.2044	0.2823
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0564	0.0855
Echinococcus granulosus	cathepsin L cysteine protease	0.0108	0.1034	0.113
Entamoeba histolytica	cysteine proteinase, putative	0.0108	0.1034	0.4938
Schistosoma mansoni	kinase	0.0026	0.0153	0.0171
Schistosoma mansoni	endoplasmin	0.0039	0.0297	0.0332
Onchocerca volvulus		0.0055	0.0471	0.0592
Plasmodium vivax	serine-repeat antigen (SERA)	0.0044	0.0345	0.1487
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0087	0.0809	0.0784
Echinococcus multilocularis	heat shock protein 75 kDa, mitochondrial	0.0016	0.0048	0.0021
Brugia malayi	Cathepsin L-like precursor	0.0202	0.2044	0.3212
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0044	0.0345	0.0454
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0553	0.0837
Giardia lamblia	Cathepsin L precursor	0.0044	0.0345	0.1359
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0202	0.2044	0.3212
Trypanosoma brucei	heat shock protein, putative	0.0039	0.0297	0.1247
Leishmania major	cysteine peptidase A (CPA)	0.0202	0.2044	1
Loa Loa (eye worm)	hypothetical protein	0.03	0.3098	0.489
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.0838	0.0938
Plasmodium vivax	vivapain-3	0.0108	0.1034	0.4938
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0115	0.1113	0.5338
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0138	0.1355	0.1862
Trypanosoma brucei	Heat shock protein 83, putative	0.0039	0.0297	0.1247
Trypanosoma cruzi	heat shock protein 90, putative	0.0031	0.0211	0.0534
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0087	0.0809	0.0906
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0202	0.2044	1
Trypanosoma cruzi	polo-like protein kinase, putative	0.0051	0.0422	0.1228
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.009	0.0838	0.1291
Trypanosoma cruzi	cysteine peptidase, putative	0.0202	0.2044	0.6545
Toxoplasma gondii	cathepsin CPL	0.0202	0.2044	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0202	0.2044	0.6545
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0202	0.2044	0.2823
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0202	0.2044	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0202	0.2044	0.2823
Onchocerca volvulus		0.0202	0.2044	0.2794
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0202	0.2044	0.2823
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0087	0.0809	0.0906
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0202	0.2044	0.2823
Plasmodium falciparum	serine repeat antigen 8	0.0044	0.0345	0.1487
Trypanosoma cruzi	cruzipain precursor, putative	0.0064	0.0564	0.1692
Entamoeba histolytica	cysteine protease, putative	0.0044	0.0345	0.1487
Leishmania major	heat shock protein 83-1	0.0039	0.0297	0.1247
Loa Loa (eye worm)	hypothetical protein	0.0138	0.1355	0.2115
Echinococcus granulosus	cathepsin l1	0.0138	0.1355	0.1492
Giardia lamblia	Cysteine protease	0.0044	0.0345	0.1359
Leishmania major	heat shock protein 83-1	0.0039	0.0297	0.1247
Trichomonas vaginalis	endoplasmin, putative	0.0024	0.0134	0.016
Onchocerca volvulus		0.0202	0.2044	0.2794
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0063	0.0553	0.0527
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0202	0.2044	1
Brugia malayi	mbt repeat family protein	0.0055	0.0471	0.0706
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0044	0.0345	0.1487
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0345	0.0454
Brugia malayi	mbt repeat family protein	0.0055	0.0471	0.0706
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0202	0.2044	0.2265
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0044	0.0345	0.0386
Echinococcus multilocularis	cysteine protease	0.0202	0.2044	0.2022
Entamoeba histolytica	cysteine protease, putative	0.0108	0.1034	0.4938
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0356	0.0524
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0345	0.0454
Trypanosoma cruzi	heat shock protein 85, putative	0.0031	0.0211	0.0534
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0044	0.0345	0.0506
Trichomonas vaginalis	CAMK family protein kinase	0.0051	0.0422	0.0562
Brugia malayi	cathepsin F-like cysteine proteinase	0.0064	0.0564	0.0855
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0138	0.1355	0.1862
Schistosoma mansoni	cathepsin F (C01 family)	0.0138	0.1355	0.1517
Giardia lamblia	Cysteine protease	0.0044	0.0345	0.1359
Trypanosoma brucei	heat shock protein 90, putative	0.0039	0.0297	0.1247
Entamoeba histolytica	cysteine protease, putative	0.0108	0.1034	0.4938
Schistosoma mansoni	cathepsin s	0.0064	0.0564	0.0631
Onchocerca volvulus		0.0202	0.2044	0.2794
Echinococcus multilocularis	cathepsin L cysteine protease	0.0202	0.2044	0.2022
Entamoeba histolytica	cysteine protease, putative	0.0044	0.0345	0.1487
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0087	0.0809	0.0906
Trypanosoma brucei	polo-like protein kinase	0.0051	0.0422	0.1876
Leishmania major	heat shock protein 83-1	0.0039	0.0297	0.1247
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0202	0.2044	1
Schistosoma mansoni	heat shock protein	0.0039	0.0297	0.0332
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0202	0.2044	0.2265
Echinococcus multilocularis	endoplasmin	0.0031	0.0211	0.0184
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.03	0.3098	0.3469
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0202	0.2044	0.2022
Plasmodium vivax	vivapain-2	0.0202	0.2044	1
Loa Loa (eye worm)	histone methyltransferase	0.0021	0.0106	0.0125
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0108	0.1034	0.3232
Entamoeba histolytica	cysteine protease, putative	0.0108	0.1034	0.4938
Trypanosoma cruzi	major cysteine proteinase, putative	0.0044	0.0345	0.0974
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0202	0.2044	0.2823
Schistosoma mansoni	heat shock protein	0.0016	0.0048	0.0053
Giardia lamblia	Cysteine protease	0.0044	0.0345	0.1359
Trichomonas vaginalis	CAMK family protein kinase	0.0051	0.0422	0.0562
Brugia malayi	latrophilin 2 splice variant baaae	0.0031	0.0204	0.0281
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0564	0.0855
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0063	0.0553	0.0591
Giardia lamblia	Hypothetical protein	0.0044	0.0345	0.1359
Loa Loa (eye worm)	transcription factor SMAD2	0.0096	0.0906	0.1399
Loa Loa (eye worm)	mbt repeat family protein	0.0055	0.0471	0.0706
Entamoeba histolytica	cysteine proteinase 1, putative	0.0108	0.1034	0.4938
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0044	0.0345	0.1487
Brugia malayi	Papain family cysteine protease containing protein	0.0108	0.1034	0.1603
Echinococcus granulosus	geminin	0.0319	0.3302	0.3678
Echinococcus granulosus	cpg binding protein	0.0063	0.0547	0.0584
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0059	0.0511	0.077
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0202	0.2044	0.2823
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0044	0.0345	0.1487
Plasmodium vivax	unspecified product	0.0044	0.0345	0.1487
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0044	0.0345	0.0506
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0044	0.0345	0.0454
Trypanosoma cruzi	cysteine peptidase, putative	0.0108	0.1034	0.3232
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0123	0.1196	0.1641
Schistosoma mansoni	hypothetical protein	0.0337	0.3496	0.3914
Leishmania major	heat shock protein 83-1	0.0039	0.0297	0.1247
Leishmania major	cathepsin L-like protease	0.0202	0.2044	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0044	0.0345	0.0506
Loa Loa (eye worm)	MBCTL1	0.0063	0.0553	0.0837
Entamoeba histolytica	cysteine protease, putative	0.0108	0.1034	0.4938
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0599	0.6306	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0108	0.1034	0.4938
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0202	0.2044	0.2823
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0129	0.1257	0.1408
Echinococcus granulosus	cathepsin b	0.03	0.3098	0.3449
Toxoplasma gondii	cathepsin B	0.0123	0.1196	0.5753
Echinococcus granulosus	SAM and MBT domain containing protein	0.0055	0.0471	0.0498
Loa Loa (eye worm)	cysteine protease	0.0202	0.2044	0.3212
Plasmodium falciparum	serine repeat antigen 6	0.0044	0.0345	0.1487
Onchocerca volvulus		0.0202	0.2044	0.2794
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0044	0.0345	0.0454
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0044	0.0345	0.0386
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0063	0.0553	0.0837
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0044	0.0345	0.1487
Schistosoma mansoni	cathepsin F (C01 family)	0.0202	0.2044	0.2289
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0202	0.2044	1
Loa Loa (eye worm)	heat shock protein 90	0.0039	0.0297	0.0429
Plasmodium vivax	endoplasmin, putative	0.0039	0.0297	0.1247
Brugia malayi	Papain family cysteine protease containing protein	0.0044	0.0345	0.0506
Brugia malayi	Pre-SET motif family protein	0.0599	0.6306	1
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0044	0.0345	0.1487
Onchocerca volvulus	Cathepsin L homolog	0.0044	0.0345	0.0416
Schistosoma mansoni	hypothetical protein	0.0031	0.0204	0.0228
Brugia malayi	Papain family cysteine protease containing protein	0.0044	0.0345	0.0506
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0202	0.2044	0.2823
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0044	0.0345	0.0386
Onchocerca volvulus	Cathepsin L homolog	0.0202	0.2044	0.2794
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0044	0.0345	0.1487
Leishmania major	heat shock protein 83-1	0.0039	0.0297	0.1247
Plasmodium vivax	unspecified product	0.0064	0.0564	0.2586
Leishmania major	heat shock protein 83-1	0.0039	0.0297	0.1247
Plasmodium vivax	unspecified product	0.0108	0.1034	0.4938
Brugia malayi	Cathepsin L-like precursor	0.0202	0.2044	0.3212
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0204	0.0281
Entamoeba histolytica	cysteine protease, putative	0.0108	0.1034	0.4938
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0044	0.0345	0.1359
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0202	0.2044	0.2823
Echinococcus multilocularis	polycomb protein SCMH1	0.0055	0.0471	0.0445
Schistosoma mansoni	cathepsin F (C01 family)	0.0202	0.2044	0.2289
Echinococcus multilocularis	heat shock protein 90	0.0039	0.0297	0.027
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0202	0.2044	0.2823
Schistosoma mansoni	cpg binding protein	0.0063	0.0547	0.0613
Loa Loa (eye worm)	MH2 domain-containing protein	0.0096	0.0906	0.1399
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0039	0.0297	0.0871
Echinococcus multilocularis	cathepsin b	0.03	0.3098	0.3079
Brugia malayi	Pre-SET motif family protein	0.0087	0.0809	0.1246
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0044	0.0345	0.0454
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0202	0.2044	0.2823
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0044	0.0345	0.1487
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0123	0.1196	0.1339
Brugia malayi	serine/threonine-protein kinase plk-2	0.0051	0.0422	0.0629
Onchocerca volvulus		0.0059	0.0511	0.0648
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0202	0.2044	1
Brugia malayi	Cathepsin L-like precursor	0.0064	0.0564	0.0855
Trypanosoma brucei	heat shock protein, putative	0.0039	0.0297	0.1247
Giardia lamblia	Cathepsin L precursor	0.0044	0.0345	0.1359
Plasmodium falciparum	serine repeat antigen 3	0.0044	0.0345	0.1487
Loa Loa (eye worm)	cathepsin B	0.0123	0.1196	0.1862
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0345	0.0506
Trichomonas vaginalis	heat shock protein, putative	0.0031	0.0211	0.0267
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0202	0.2044	0.2823
Echinococcus granulosus	cathepsin L	0.0044	0.0345	0.0357
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0055	0.0471	0.0592
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0044	0.0345	0.0454
Plasmodium vivax	vivapain-1	0.0108	0.1034	0.4938
Giardia lamblia	Cathepsin L precursor	0.0044	0.0345	0.1359
Brugia malayi	fibroinase precursor	0.0044	0.0345	0.0506
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0202	0.2044	0.2823
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0063	0.0553	0.0527
Brugia malayi	Cathepsin L-like precursor	0.0202	0.2044	0.3212
Echinococcus granulosus	histone acetyltransferase MYST2	0.0063	0.0553	0.0591
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.0031	0.0211	0.0206
Giardia lamblia	Cathepsin B precursor	0.0044	0.0345	0.1359
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.03	0.3098	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0064	0.0564	0.0855
Leishmania major	cathepsin L-like protease	0.0202	0.2044	1
Schistosoma mansoni	hypothetical protein	0.0319	0.3302	0.3697
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0202	0.2044	1
Echinococcus multilocularis	cathepsin L	0.0108	0.1034	0.1009
Loa Loa (eye worm)	hypothetical protein	0.0202	0.2044	0.3212
Trichomonas vaginalis	CAMK family protein kinase	0.0051	0.0422	0.0562
Echinococcus granulosus	cathepsin L	0.0108	0.1034	0.113
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0202	0.2044	0.2823
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0021	0.0106	0.0088
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0087	0.0809	0.0906
Schistosoma mansoni	hypothetical protein	0.0014	0.0027	0.003
Leishmania major	cathepsin L-like protease	0.0202	0.2044	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0202	0.2044	0.2823
Entamoeba histolytica	cysteine protease, putative	0.0108	0.1034	0.4938
Giardia lamblia	Kinase, PLK	0.0051	0.0422	0.2147
Schistosoma mansoni	cpg binding protein	0.0059	0.0511	0.0572
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0044	0.0345	0.1487
Trypanosoma brucei	heat shock protein, putative	0.0039	0.0297	0.1247
Echinococcus granulosus	cathepsin l1	0.0202	0.2044	0.2265
Leishmania major	cathepsin L-like protease	0.0202	0.2044	1
Trypanosoma cruzi	heat shock protein 85, putative	0.0039	0.0297	0.0816
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0045	0.0356	0.0524
Trypanosoma brucei	heat shock protein, putative	0.0039	0.0297	0.1247
Echinococcus multilocularis	geminin	0.0319	0.3302	0.3283
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0044	0.0345	0.1359
Trypanosoma cruzi	cysteine peptidase, putative	0.0202	0.2044	0.6545
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0202	0.2044	0.2823
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0083	0.0762	0.0825
Brugia malayi	Hsp90 protein	0.0016	0.0048	0.0033
Giardia lamblia	Cathepsin B precursor	0.0044	0.0345	0.1359
Entamoeba histolytica	cysteine proteinase, putative	0.0138	0.1355	0.6549
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0202	0.2044	0.2823
Echinococcus multilocularis	cathepsin b	0.03	0.3098	0.3079
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0108	0.1034	0.1414
Trichomonas vaginalis	CAMK family protein kinase	0.0051	0.0422	0.0562
Entamoeba histolytica	cysteine protease, putative	0.0108	0.1034	0.4938
Giardia lamblia	Encystation-specific protease	0.0044	0.0345	0.1359
Onchocerca volvulus	Cathepsin L homolog	0.0202	0.2044	0.2794
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0018	0.0067	0.004

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 0.31 uM	Antiproliferative activity against human A2780 cells after 72 hrs by alamar blue assay	ChEMBL.	22632933
IC50 (binding)	= 0.78 uM	Displacement of [3H]17AAG from human recombinant Hsp90 after 30 mins by beta scintillation counting	ChEMBL.	22632933

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	22632933

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2042760

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1654265