Detailed information for compound 1654898

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 360.452 | Formula: C22H24N4O
  • H donors: 0 H acceptors: 2 LogP: 3.12 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1N(CCN2CCCC2)CCc2c1ccc(c2)n1cnc2c1cccc2
  • InChi: 1S/C22H24N4O/c27-22-19-8-7-18(26-16-23-20-5-1-2-6-21(20)26)15-17(19)9-12-25(22)14-13-24-10-3-4-11-24/h1-2,5-8,15-16H,3-4,9-14H2
  • InChiKey: BTHDBDIXZQYFMB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Histamine H3 receptor Starlite/ChEMBL References
Homo sapiens histamine receptor H3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) hypothetical protein Histamine H3 receptor   445 aa 384 aa 22.4 %
Echinococcus granulosus biogenic amine 5HT receptor Histamine H3 receptor   445 aa 405 aa 25.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.1189 0.1734
Schistosoma mansoni nephrin 0.0012 0.0072 0.0108
Echinococcus multilocularis tubulin subunit TubB 0.0096 0.2903 0.4233
Entamoeba histolytica protein kinase, putative 0.0015 0.0192 0.0663
Echinococcus multilocularis Tubulin alpha 1 chain 0.0096 0.2903 0.4233
Echinococcus granulosus tubulin alpha chain 0.0096 0.2903 0.4233
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0083 0.2476 0.361
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0038 0.097 0.1414
Loa Loa (eye worm) TK protein kinase 0.0038 0.097 0.1414
Toxoplasma gondii alpha tubulin TUBA1 0.0096 0.2903 1
Trypanosoma brucei tubulin gamma chain 0.009 0.2706 0.2563
Leishmania major alpha tubulin 0.0096 0.2903 0.2829
Echinococcus granulosus Tubulin beta 2C chain 0.0078 0.2309 0.3366
Brugia malayi hypothetical protein 0.0065 0.1876 0.3671
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0913 0.1376
Echinococcus granulosus NCK adaptor protein 0.0013 0.0128 0.0187
Brugia malayi Methionine aminopeptidase protein type I 0.0042 0.1107 0.2166
Trypanosoma brucei alpha tubulin 0.0096 0.2903 0.2764
Trichomonas vaginalis tubulin beta chain, putative 0.0096 0.2903 1
Brugia malayi Sex muscle abnormal protein 5 0.0013 0.0128 0.0251
Echinococcus granulosus Tubulin alpha 1 chain 0.0096 0.2903 0.4233
Brugia malayi SRC-1 0.0045 0.1189 0.2327
Trichomonas vaginalis tubulin alpha chain, putative 0.0032 0.0767 0.2371
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0723 0.2213
Loa Loa (eye worm) hypothetical protein 0.0013 0.0128 0.0187
Brugia malayi beta-tubulin, identical 0.0078 0.2309 0.4518
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0913 0.0818
Echinococcus granulosus tubulin alpha chain 0.0096 0.2903 0.4233
Echinococcus granulosus single minded 2 0.0036 0.0881 0.1284
Trichomonas vaginalis tubulin beta chain, putative 0.0032 0.0767 0.2371
Leishmania major beta tubulin 0.0078 0.2309 0.2228
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.1702 1
Leishmania major alpha tubulin 0.0096 0.2903 0.2829
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.0192 0.029
Mycobacterium leprae cell division protein FtsZ 0.0031 0.0723 0.6177
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0042 0.1107 0.1613
Echinococcus granulosus tubulin alpha 1C chain 0.0096 0.2903 0.4233
Echinococcus multilocularis tyrosine protein kinase HCK 0.0032 0.0744 0.1085
Onchocerca volvulus Huntingtin homolog 0.0122 0.3757 0.8456
Trypanosoma brucei tubulin delta chain 0.0031 0.0723 0.0541
Schistosoma mansoni hypothetical protein 0.0051 0.1403 0.2115
Leishmania major alpha tubulin 0.0096 0.2903 0.2829
Loa Loa (eye worm) tubulin alpha 2 0.0033 0.0779 0.1136
Brugia malayi hypothetical protein 0.0122 0.3757 0.7352
Echinococcus granulosus jun protein 0.0083 0.2476 0.361
Leishmania major beta tubulin 0.0078 0.2309 0.2228
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0164 0.032
Echinococcus multilocularis growth factor receptor bound protein 2 0.0013 0.0128 0.0187
Schistosoma mansoni protein kinase 0.0015 0.0192 0.029
Brugia malayi intermediate filament protein 0.0027 0.058 0.1135
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0116 0.0169
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0881 0.1723
Echinococcus multilocularis roundabout 2 0.0015 0.0173 0.0252
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0913 0.1331
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.0042 0.1107 0.3916
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0913 0.1787
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0913 0.1331
Loa Loa (eye worm) hypothetical protein 0.0081 0.2399 0.3498
Schistosoma mansoni tubulin subunit alpha 0.0031 0.0723 0.109
Echinococcus multilocularis tubulin alpha 0.0063 0.1807 0.2635
Brugia malayi Tyrosine-protein kinase abl-1 0.0126 0.392 0.767
Brugia malayi Tubulin gamma chain 0.009 0.2706 0.5295
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.1702 0.2566
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0031 0.0723 0.1957
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.0042 0.1107 0.3916
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.1301 0.1961
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0015 0.0192 0.0281
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0913 0.1331
Schistosoma mansoni adapter molecule crk 0.0013 0.0128 0.0193
Leishmania major beta tubulin 0.0078 0.2309 0.2228
Echinococcus granulosus tubulin alpha chain 0.0096 0.2903 0.4233
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.1702 1
Brugia malayi tubulin alpha-2 chain 0.0096 0.2903 0.5681
Leishmania major alpha tubulin 0.0096 0.2903 0.2829
Schistosoma mansoni tyrosine kinase 0.0045 0.1189 0.1793
Echinococcus granulosus roundabout 2 0.0015 0.0173 0.0252
Echinococcus granulosus geminin 0.0168 0.5318 0.7753
Echinococcus granulosus beta tubulin 0.0078 0.2309 0.3366
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0015 0.0192 0.0281
Loa Loa (eye worm) TK/ABL protein kinase 0.0214 0.6859 1
Trichomonas vaginalis tubulin, putative 0.0032 0.0767 0.2371
Echinococcus granulosus tubulin subunit beta 0.0078 0.2309 0.3366
Echinococcus multilocularis Tubulin beta 2C chain 0.0078 0.2309 0.3366
Trichomonas vaginalis tubulin alpha chain, putative 0.0078 0.2309 0.7877
Mycobacterium ulcerans methionine aminopeptidase 0.0042 0.1107 0.3916
Echinococcus granulosus tyrosine protein kinase Blk 0.0038 0.097 0.1414
Onchocerca volvulus 0.0036 0.0881 0.1982
Trypanosoma brucei beta tubulin 0.0078 0.2309 0.2158
Brugia malayi Tubulin alpha chain 0.0031 0.0723 0.1415
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.1702 1
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) 0.0042 0.1107 1
Giardia lamblia Beta tubulin 0.0078 0.2309 0.7273
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0016 0.022 0.032
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.1702 0.2482
Chlamydia trachomatis methionine aminopeptidase 0.0042 0.1107 1
Treponema pallidum methionine aminopeptidase (map) 0.0042 0.1107 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.1819 0.2652
Brugia malayi Tyrosine-protein kinase abl-1 0.0094 0.2842 0.5562
Echinococcus granulosus tubulin alpha 3 chain 0.0096 0.2903 0.4233
Trypanosoma cruzi beta tubulin, putative 0.0078 0.2309 0.2228
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0015 0.0192 0.0376
Schistosoma mansoni tubulin subunit alpha 0.0096 0.2903 0.4377
Echinococcus granulosus tyrosine protein kinase Src42A 0.0036 0.0878 0.128
Echinococcus granulosus Tubulin alpha 1 chain 0.0096 0.2903 0.4233
Echinococcus multilocularis tubulin gamma 1 chain 0.009 0.2706 0.3945
Plasmodium vivax tubulin beta chain, putative 0.0078 0.2309 0.7807
Loa Loa (eye worm) hypothetical protein 0.0096 0.2903 0.4233
Leishmania major alpha tubulin 0.0096 0.2903 0.2829
Echinococcus multilocularis tubulin alpha chain 0.0096 0.2903 0.4233
Trichomonas vaginalis tubulin gamma chain, putative 0.009 0.2706 0.9295
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.0042 0.1107 0.3372
Echinococcus multilocularis Tubulin beta 2C chain 0.0078 0.2309 0.3366
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0036 0.0878 0.128
Schistosoma mansoni tubulin subunit beta 0.0078 0.2309 0.3481
Onchocerca volvulus 0.0032 0.0767 0.1727
Echinococcus granulosus tubulin subunit TubB 0.0096 0.2903 0.4233
Onchocerca volvulus 0.0013 0.0104 0.0233
Brugia malayi Cell division protein ftsZ 0.0031 0.0723 0.1415
Schistosoma mansoni tubulin subunit delta 0.0031 0.0723 0.109
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.0042 0.1107 1
Echinococcus granulosus tyrosine protein kinase Src64B 0.0045 0.1189 0.1734
Entamoeba histolytica tubulin alpha chain, putative 0.0096 0.2903 1
Echinococcus multilocularis tubulin alpha chain 0.0096 0.2903 0.4233
Loa Loa (eye worm) intermediate filament protein 0.0027 0.058 0.0846
Leishmania major beta tubulin 0.0078 0.2309 0.2228
Schistosoma mansoni tubulin subunit beta 0.0078 0.2309 0.3481
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.0114 0.001
Echinococcus granulosus beta tubulin 0.0078 0.2309 0.3366
Leishmania major beta tubulin 0.0078 0.2309 0.2228
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0013 0.0128 0.0187
Echinococcus granulosus tubulin epsilon chain 0.0063 0.1807 0.2635
Echinococcus multilocularis tubulin alpha 1C chain 0.0096 0.2903 0.4233
Plasmodium falciparum alpha tubulin 1 0.0096 0.2903 1
Schistosoma mansoni lamin 0.0027 0.058 0.0874
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0065 0.1863 0.6286
Loa Loa (eye worm) hypothetical protein 0.0015 0.0173 0.0252
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.1702 0.2482
Trichomonas vaginalis tubulin gamma chain, putative 0.0078 0.2309 0.7877
Trichomonas vaginalis tubulin beta chain, putative 0.0096 0.2903 1
Mycobacterium ulcerans methionine aminopeptidase MapB 0.0042 0.1107 0.3916
Loa Loa (eye worm) hypothetical protein 0.0015 0.0173 0.0252
Echinococcus granulosus aryl hydrocarbon receptor 0.0013 0.0104 0.0151
Schistosoma mansoni tyrosine kinase 0.0016 0.022 0.0331
Trypanosoma cruzi tubulin delta chain 0.0031 0.0723 0.0626
Trypanosoma brucei epsilon tubulin 0.0063 0.1807 0.1647
Leishmania major alpha tubulin 0.0096 0.2903 0.2829
Leishmania major alpha tubulin 0.0096 0.2903 0.2829
Schistosoma mansoni jun-related protein 0.0068 0.1953 0.2944
Loa Loa (eye worm) tubulin alpha chain 0.0096 0.2903 0.4233
Echinococcus granulosus c src tyrosine kinase 0.0016 0.022 0.032
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0723 0.2213
Schistosoma mansoni protein kinase 0.0015 0.0192 0.029
Loa Loa (eye worm) hypothetical protein 0.0065 0.1863 0.2717
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0913 0.2891
Echinococcus granulosus neuroglian 0.0012 0.0072 0.0105
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0214 0.6859 1
Echinococcus multilocularis tubulin delta chain 0.0031 0.0723 0.1054
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.1189 0.1734
Leishmania major beta tubulin 0.0078 0.2309 0.2228
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0078 0.2309 0.3366
Echinococcus granulosus Tubulin alpha 1 chain 0.0096 0.2903 0.4233
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.0114 0.001
Plasmodium falciparum tubulin beta chain 0.0078 0.2309 0.7807
Echinococcus granulosus alpha tubulin 0.0096 0.2903 0.4233
Echinococcus granulosus twitchin 0.0012 0.0082 0.012
Plasmodium vivax methionine aminopeptidase 1a, putative 0.0042 0.1107 0.3372
Onchocerca volvulus Tyrosine kinase homolog 0.0142 0.4443 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.2397 0.3495
Brugia malayi protein-tyrosine kinase 0.0038 0.097 0.1897
Echinococcus granulosus tubulin delta chain 0.0031 0.0723 0.1054
Leishmania major beta tubulin 0.0078 0.2309 0.2228
Trypanosoma brucei alpha tubulin 0.0096 0.2903 0.2764
Echinococcus granulosus tubulin alpha 1C chain 0.0096 0.2903 0.4233
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.0042 0.1107 0.0932
Schistosoma mansoni tubulin subunit gamma 0.009 0.2706 0.4079
Echinococcus multilocularis tubulin alpha chain 0.0096 0.2903 0.4233
Leishmania major beta tubulin 0.0078 0.2309 0.2228
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0045 0.1189 0.1734
Schistosoma mansoni tubulin subunit beta 0.0078 0.2309 0.3481
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0063 0.1807 0.5957
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0038 0.097 0.1414
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.1189 0.1734
Plasmodium vivax methionine aminopeptidase 1b, putative 0.0042 0.1107 0.3372
Trichomonas vaginalis tubulin beta chain, putative 0.0078 0.2309 0.7877
Trypanosoma brucei alpha tubulin 0.0096 0.2903 0.2764
Schistosoma mansoni tubulin subunit beta 0.0078 0.2309 0.3481
Echinococcus multilocularis musashi 0.0027 0.058 0.0846
Leishmania major protein kinase, putative 0.0013 0.0114 0.001
Trypanosoma cruzi alpha tubulin, putative 0.0096 0.2903 0.2829
Echinococcus multilocularis tubulin alpha 3 chain 0.0096 0.2903 0.4233
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0013 0.0104 0.0151
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0913 0.1376
Toxoplasma gondii methionine aminopeptidase 0.0042 0.1107 0.3372
Schistosoma mansoni single-minded 0.0048 0.1301 0.1961
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0045 0.1189 0.1734
Leishmania major gamma-tubulin 0.009 0.2706 0.2629
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.1189 0.1734
Echinococcus multilocularis calcium dependent protein kinase 0.0015 0.0182 0.0266
Loa Loa (eye worm) tubulin alpha 2 0.0065 0.1863 0.2717
Loa Loa (eye worm) hypothetical protein 0.0012 0.01 0.0145
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.1702 0.557
Leishmania major beta tubulin 0.0078 0.2309 0.2228
Schistosoma mansoni tubulin subunit epsilon 0.0063 0.1807 0.2725
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0913 0.0871
Plasmodium falciparum tubulin delta chain, putative 0.0031 0.0723 0.1957
Schistosoma mansoni tubulin subunit alpha 0.0096 0.2903 0.4377
Trypanosoma brucei zeta tubulin, putative 0.0308 1 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0152 0.4774 0.9343
Trichomonas vaginalis tubulin epsilon chain, putative 0.0096 0.2903 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.0096 0.2903 0.4233
Loa Loa (eye worm) hypothetical protein 0.0012 0.0094 0.0136
Echinococcus granulosus tubulin alpha 0.0063 0.1807 0.2635
Brugia malayi Tubulin alpha chain 0.0096 0.2903 0.5681
Brugia malayi Cam kinase protein 1 0.0015 0.0192 0.0376
Trichomonas vaginalis tubulin gamma chain, putative 0.0063 0.1807 0.6085
Trypanosoma cruzi epsilon tubulin, putative 0.0063 0.1807 0.1721
Loa Loa (eye worm) TK protein kinase 0.0032 0.0744 0.1085
Echinococcus multilocularis Tubulin alpha 1 chain 0.0096 0.2903 0.4233
Brugia malayi Cytochrome P450 family protein 0.0026 0.0553 0.1082
Trichomonas vaginalis tubulin alpha chain, putative 0.0063 0.1807 0.6085
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0913 0.2891
Trypanosoma cruzi tubulin delta chain 0.0031 0.0723 0.0626
Onchocerca volvulus 0.0027 0.058 0.1306
Echinococcus multilocularis tubulin alpha chain 0.0096 0.2903 0.4233
Trypanosoma brucei beta tubulin 0.0063 0.1807 0.1647
Loa Loa (eye worm) hypothetical protein 0.0122 0.3757 0.5478
Echinococcus granulosus Tubulin beta 2C chain 0.0078 0.2309 0.3366
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0015 0.0192 0.0281
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.1189 0.1734
Brugia malayi tubulin alpha chain - mouse 0.0096 0.2903 0.5681
Leishmania major alpha tubulin 0.0096 0.2903 0.2829
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0032 0.0767 0.2371
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0015 0.0192 0.0281
Loa Loa (eye worm) hypoxia-induced factor 1 0.0149 0.469 0.6838
Echinococcus granulosus tyrosine protein kinase ABL1 0.0214 0.6859 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0114 0.001
Trichomonas vaginalis tubulin epsilon chain, putative 0.0031 0.0723 0.2213
Plasmodium vivax delta tubulin, putative 0.0031 0.0723 0.1957
Trichomonas vaginalis CAMK family protein kinase 0.0015 0.0192 0.0317
Leishmania major protein kinase, putative 0.0013 0.0114 0.001
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0045 0.1189 0.1734
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0913 0.0735
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0016 0.022 0.032
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0064 0.1819 0.6128
Trichomonas vaginalis tubulin beta chain, putative 0.0096 0.2903 1
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0042 0.1107 0.1668
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) 0.0042 0.1107 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0015 0.0192 0.0281
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0015 0.0192 0.0281
Entamoeba histolytica protein kinase, putative 0.0015 0.0192 0.0663
Loa Loa (eye worm) tubulin beta chain 0.0078 0.2309 0.3366
Echinococcus multilocularis beta tubulin 0.0078 0.2309 0.3366
Echinococcus granulosus lamin 0.0027 0.058 0.0846
Trichomonas vaginalis tubulin epsilon chain, putative 0.0096 0.2903 1
Leishmania major beta tubulin 0.0078 0.2309 0.2228
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0881 0.1607
Echinococcus multilocularis jun protein 0.0083 0.2476 0.361
Loa Loa (eye worm) tubulin alpha 2 0.0065 0.1863 0.2717
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0042 0.1107 0.1013
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0013 0.0104 0.0151
Leishmania major beta tubulin 0.0078 0.2309 0.2228
Loa Loa (eye worm) tubulin alpha chain 0.0096 0.2903 0.4233
Trichomonas vaginalis tubulin gamma chain, putative 0.0031 0.0723 0.2213
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0015 0.0192 0.0281
Echinococcus granulosus tubulin alpha chain 0.0096 0.2903 0.4233
Entamoeba histolytica tubulin alpha-1 chain 0.0096 0.2903 1
Trichomonas vaginalis tubulin, putative 0.0078 0.2309 0.7877
Echinococcus granulosus growth factor receptor bound protein 2 0.0013 0.0128 0.0187
Schistosoma mansoni hypothetical protein 0.0068 0.1953 0.2944
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.1702 0.2566
Echinococcus multilocularis lamin 0.0027 0.058 0.0846
Giardia lamblia Beta tubulin 0.0078 0.2309 0.7273
Trichomonas vaginalis tubulin, putative 0.0058 0.1622 0.5422
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0045 0.1189 0.1734
Brugia malayi Tubulin beta chain 0.0031 0.0723 0.1415
Echinococcus granulosus Tubulin beta 2C chain 0.0078 0.2309 0.3366
Loa Loa (eye worm) beta-tubulin 0.0078 0.2309 0.3366
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0152 0.4774 0.6961
Echinococcus multilocularis c src tyrosine kinase 0.0016 0.022 0.032
Trichomonas vaginalis tubulin beta chain, putative 0.0096 0.2903 1
Echinococcus multilocularis NCK adaptor protein 0.0013 0.0128 0.0187
Echinococcus multilocularis tubulin subunit beta 0.0078 0.2309 0.3366
Leishmania major beta tubulin 0.0078 0.2309 0.2228
Loa Loa (eye worm) alpha-tubulin 0.0096 0.2903 0.4233
Trypanosoma brucei alpha tubulin, putative 0.0032 0.0767 0.0586
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0045 0.1189 0.1734
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0065 0.1863 0.2717
Loa Loa (eye worm) hypothetical protein 0.0012 0.01 0.0145
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0164 0.0239
Echinococcus multilocularis hypothetical protein 0.0096 0.2903 0.4233
Schistosoma mansoni alpha tubulin 0.0096 0.2903 0.4377
Echinococcus multilocularis tyrosine protein kinase Abl 0.0094 0.2842 0.4144
Giardia lamblia Alpha-tubulin 0.0096 0.2903 1
Schistosoma mansoni lamin 0.0027 0.058 0.0874
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0096 0.2903 1
Onchocerca volvulus Huntingtin homolog 0.0122 0.3757 0.8456
Schistosoma mansoni hypothetical protein 0.0168 0.5318 0.8017
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0913 0.0818
Echinococcus granulosus peroxisome assembly protein 26 0.0096 0.2903 0.4233
Schistosoma mansoni intermediate filament proteins 0.0027 0.058 0.0874
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0114 0.001
Plasmodium falciparum tubulin gamma chain 0.009 0.2706 0.9271
Trypanosoma brucei beta tubulin 0.0078 0.2309 0.2158
Echinococcus multilocularis tubulin alpha 1C chain 0.0096 0.2903 0.4233
Trichomonas vaginalis tubulin epsilon chain, putative 0.0078 0.2309 0.7877
Echinococcus granulosus tyrosine protein kinase Src42A 0.0045 0.1189 0.1734
Echinococcus granulosus tubulin beta 4A class IVa 0.0078 0.2309 0.3366
Loa Loa (eye worm) tubulin beta chain 0.0031 0.0723 0.1054
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.0042 0.1107 0.3372
Leishmania major beta tubulin 0.0078 0.2309 0.2228
Trypanosoma brucei beta tubulin 0.0078 0.2309 0.2158
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0015 0.0192 0.0281
Schistosoma mansoni tyrosine kinase 0.0207 0.6634 1
Plasmodium falciparum alpha tubulin 2 0.0096 0.2903 1
Leishmania major beta tubulin 0.0078 0.2309 0.2228
Echinococcus granulosus tubulin beta 1 chain 0.0078 0.2309 0.3366
Loa Loa (eye worm) hypothetical protein 0.0013 0.0104 0.0151
Echinococcus granulosus tyrosine kinase 0.0038 0.097 0.1414
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0013 0.0128 0.0187
Toxoplasma gondii beta-1 tubulin, putative 0.0078 0.2309 0.7807
Trichomonas vaginalis tubulin alpha chain, putative 0.0032 0.0767 0.2371
Echinococcus multilocularis tubulin epsilon chain 0.0063 0.1807 0.2635
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0031 0.0723 0.1957
Echinococcus multilocularis Tubulin beta 2C chain 0.0078 0.2309 0.3366
Echinococcus multilocularis beta tubulin 0.0078 0.2309 0.3366
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0042 0.1107 0.1013
Leishmania major delta tubulin, putative 0.0031 0.0723 0.0626
Echinococcus multilocularis tyrosine protein kinase Srms 0.0038 0.097 0.1414
Echinococcus multilocularis tubulin alpha chain 0.0096 0.2903 0.4233
Loa Loa (eye worm) tubulin alpha-2 chain 0.0096 0.2903 0.4233
Toxoplasma gondii beta-tubulin, putative 0.0078 0.2309 0.7807
Loa Loa (eye worm) tubulin alpha-3 chain 0.0064 0.1819 0.2652
Trypanosoma brucei beta tubulin 0.0078 0.2309 0.2158
Loa Loa (eye worm) methionine aminopeptidase type I 0.0042 0.1107 0.1613
Toxoplasma gondii beta tubulin 0.0078 0.2309 0.7807
Trypanosoma cruzi zeta tubulin, putative 0.0308 1 1
Schistosoma mansoni tyrosine kinase 0.0016 0.022 0.0331
Entamoeba histolytica tubulin family protein 0.0078 0.2309 0.7953
Brugia malayi Tubulin beta-1 chain 0.0078 0.2309 0.4518
Brugia malayi hypothetical protein 0.0162 0.511 1
Leishmania major alpha tubulin 0.0096 0.2903 0.2829
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0913 0.1331
Echinococcus granulosus Tubulin beta 2C chain 0.0078 0.2309 0.3366
Echinococcus granulosus calcium dependent protein kinase 0.0015 0.0182 0.0266
Onchocerca volvulus 0.0027 0.058 0.1306
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.1702 1
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.0042 0.1107 0.1613
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.058 0.0846
Brugia malayi Variant SH3 domain containing protein 0.0013 0.0128 0.0251
Echinococcus multilocularis lamin dm0 0.0027 0.058 0.0846
Loa Loa (eye worm) hypothetical protein 0.0122 0.3757 0.5478
Schistosoma mansoni tubulin subunit beta 0.0078 0.2309 0.3481
Loa Loa (eye worm) tubulin beta-1 chain 0.0078 0.2309 0.3366
Brugia malayi hypoxia-induced factor 1 0.0149 0.469 0.9177
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0016 0.022 0.0331
Trypanosoma brucei alpha tubulin 0.0096 0.2903 0.2764
Loa Loa (eye worm) hypothetical protein 0.0013 0.0116 0.0169
Echinococcus granulosus intermediate filament protein 0.0027 0.058 0.0846
Loa Loa (eye worm) BEN-1 protein 0.0078 0.2309 0.3366
Leishmania major epsilon tubulin, putative 0.0063 0.1807 0.1721
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0031 0.0723 0.2213
Echinococcus granulosus tubulin alpha chain 0.0096 0.2903 0.4233
Leishmania major beta tubulin 0.0078 0.2309 0.2228
Echinococcus granulosus lamin dm0 0.0027 0.058 0.0846
Loa Loa (eye worm) SRC-1 0.0045 0.1189 0.1734
Brugia malayi Tubulin alpha-2 chain 0.0096 0.2903 0.5681
Trichomonas vaginalis tubulin beta chain, putative 0.0096 0.2903 1
Loa Loa (eye worm) tubulin beta-2A chain 0.0078 0.2309 0.3366
Brugia malayi alpha-tubulin 0.0096 0.2903 0.5681
Leishmania major alpha tubulin 0.0096 0.2903 0.2829
Schistosoma mansoni cell adhesion molecule 0.0012 0.0094 0.0141
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0913 0.3145
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0553 0.0807
Echinococcus multilocularis neuroglian 0.0012 0.0072 0.0105
Loa Loa (eye worm) hypothetical protein 0.0026 0.0564 0.0822
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0913 0.0818
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0013 0.0104 0.0151
Loa Loa (eye worm) hypothetical protein 0.0162 0.511 0.7451
Schistosoma mansoni tubulin subunit beta 0.0031 0.0723 0.109
Plasmodium falciparum tubulin epsilon chain, putative 0.0063 0.1807 0.5957
Trypanosoma brucei epsilon tubulin 0.0063 0.1807 0.1647
Brugia malayi Variant SH3 domain containing protein 0.0013 0.0128 0.0251
Echinococcus multilocularis tubulin alpha 3 chain 0.0096 0.2903 0.4233
Trichomonas vaginalis tubulin, putative 0.0032 0.0767 0.2371
Entamoeba histolytica tubulin family protein 0.0078 0.2309 0.7953
Brugia malayi Tubulin alpha-2 chain 0.0096 0.2903 0.5681
Brugia malayi Tubulin beta chain 0.0032 0.0767 0.1502
Onchocerca volvulus 0.0137 0.4273 0.9617
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0083 0.2476 0.361
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0913 0.1331
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0045 0.1189 0.1734
Brugia malayi PAS domain containing protein 0.0048 0.1301 0.2546
Plasmodium vivax tubulin gamma chain, putative 0.009 0.2706 0.9271
Trypanosoma brucei zeta tubulin 0.0308 1 1
Echinococcus multilocularis tubulin beta 1 chain 0.0078 0.2309 0.3366
Giardia lamblia Alpha-tubulin 0.0096 0.2903 1
Schistosoma mansoni tubulin subunit alpha 0.0096 0.2903 0.4377
Giardia lamblia Beta tubulin 0.0078 0.2309 0.7273
Leishmania major beta tubulin 0.0078 0.2309 0.2228
Trypanosoma cruzi tubulin gamma chain 0.009 0.2706 0.2629
Plasmodium vivax tubulin epsilon chain, putative 0.0063 0.1807 0.5957
Echinococcus multilocularis aryl hydrocarbon receptor 0.0013 0.0104 0.0151
Echinococcus granulosus tubulin gamma 1 chain 0.009 0.2706 0.3945
Trichomonas vaginalis tubulin alpha chain, putative 0.0032 0.0767 0.2371
Entamoeba histolytica tubulin gamma chain 0.009 0.2706 0.932
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0042 0.1107 0.1668
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0045 0.1189 0.1734
Loa Loa (eye worm) alpha-tubulin 0.0096 0.2903 0.4233
Trichomonas vaginalis tubulin epsilon chain, putative 0.0078 0.2309 0.7877
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0013 0.0128 0.0193
Schistosoma mansoni growth factor receptor-bound protein 0.0013 0.0128 0.0193
Toxoplasma gondii methionine aminopeptidase 0.0042 0.1107 0.3372
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.1189 0.1734
Onchocerca volvulus 0.0065 0.1876 0.4223
Echinococcus multilocularis tyrosine protein kinase Blk 0.0038 0.097 0.1414
Entamoeba histolytica protein kinase, putative 0.0032 0.0744 0.2564
Toxoplasma gondii alpha-tubulin I, putative 0.0096 0.2903 1
Giardia lamblia Gamma tubulin 0.009 0.2706 0.9094
Schistosoma mansoni growth factor receptor-bound protein 0.0013 0.0128 0.0193
Loa Loa (eye worm) hypothetical protein 0.0037 0.0913 0.1331
Trichomonas vaginalis tubulin beta chain, putative 0.0096 0.2903 1
Schistosoma mansoni tubulin subunit beta 0.0078 0.2309 0.3481
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.0042 0.1107 0.0932
Echinococcus granulosus Tubulin beta 2C chain 0.0078 0.2309 0.3366
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0045 0.1189 0.1734
Loa Loa (eye worm) hypothetical protein 0.0027 0.058 0.0846
Echinococcus granulosus tyrosine protein kinase HCK 0.0032 0.0744 0.1085
Schistosoma mansoni alpha tubulin 0.0096 0.2903 0.4377
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0913 0.2891
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0042 0.1107 0.1613
Schistosoma mansoni protein kinase 0.0015 0.0192 0.029
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.0042 0.1107 0.3372
Echinococcus granulosus tubulin alpha 3 chain 0.0096 0.2903 0.4233
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.058 0.1135
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0015 0.0192 0.0281
Schistosoma mansoni tyrosine kinase 0.0045 0.1189 0.1793
Echinococcus multilocularis geminin 0.0168 0.5318 0.7753
Loa Loa (eye worm) BEN-1 protein 0.0078 0.2309 0.3366
Trypanosoma cruzi epsilon tubulin, putative 0.0063 0.1807 0.1721
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0015 0.0192 0.0281
Echinococcus granulosus tyrosine protein kinase Lyn 0.0045 0.12 0.1749
Schistosoma mansoni alpha tubulin 0.0096 0.2903 0.4377
Leishmania major alpha tubulin 0.0096 0.2903 0.2829
Leishmania major beta tubulin 0.0078 0.2309 0.2228
Echinococcus multilocularis peroxisome assembly protein 26 0.0096 0.2903 0.4233
Echinococcus multilocularis Tubulin beta 2C chain 0.0078 0.2309 0.3366
Loa Loa (eye worm) hypothetical protein 0.0015 0.0192 0.0281
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0881 0.1284
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0116 0.0169
Plasmodium vivax tubulin alpha chain, putative 0.0096 0.2903 1
Leishmania major beta tubulin 0.0078 0.2309 0.2228
Echinococcus multilocularis Tubulin beta 2C chain 0.0078 0.2309 0.3366
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0913 0.1331
Trypanosoma brucei epsilon tubulin 0.0063 0.1807 0.1647
Leishmania major alpha tubulin 0.0096 0.2903 0.2829
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.1702 0.1615
Leishmania major protein kinase, putative 0.0015 0.0192 0.009
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0042 0.1107 0.1013
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0012 0.0094 0.0136
Schistosoma mansoni hypothetical protein 0.0168 0.5318 0.8017
Trypanosoma brucei methionine aminopeptidase, putative 0.0042 0.1107 0.0932
Loa Loa (eye worm) tubulin beta-4 chain 0.0078 0.2309 0.3366
Trypanosoma cruzi zeta tubulin, putative 0.0308 1 1
Plasmodium vivax tubulin alpha chain, putative 0.0096 0.2903 1
Loa Loa (eye worm) tubulin gamma chain 0.009 0.2706 0.3945
Brugia malayi bZIP transcription factor family protein 0.0083 0.2476 0.4845
Schistosoma mansoni nck2/grb4 0.0013 0.0128 0.0193

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.8 nM Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting ChEMBL. 22313242
Ki (binding) = 174 nM Displacement of [3H]-(R)-alpha-methylhistamine from rat H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting ChEMBL. 22313242

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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