Detailed information for compound 1655464

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 463.787 | Formula: C22H21Cl3N4O
  • H donors: 2 H acceptors: 2 LogP: 5.54 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)N[C@@H]1CCCNC1
  • InChi: 1S/C22H21Cl3N4O/c1-13-20(22(30)27-17-3-2-10-26-12-17)28-29(19-9-8-16(24)11-18(19)25)21(13)14-4-6-15(23)7-5-14/h4-9,11,17,26H,2-3,10,12H2,1H3,(H,27,30)/t17-/m1/s1
  • InChiKey: ZBQIRTZFJVLJSH-QGZVFWFLSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0007 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0002
Mycobacterium tuberculosis Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) 0.0302 0.331 1
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0152 0.1626 0.1626
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0002 0.0002
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0271 0.0271
Schistosoma mansoni potassium channel beta 0.0009 0.0024 0.0024
Echinococcus granulosus G protein coupled receptor 139 0.0007 0.0002 0.0002
Echinococcus multilocularis fmrfamide receptor 0.0007 0.0002 0.0002
Echinococcus multilocularis aldo keto reductase 0.0031 0.0271 0.0271
Brugia malayi hypothetical protein 0.0152 0.1626 0.1626
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0009 0.0024 0.0073
Onchocerca volvulus 0.0007 0.0002 0.0006
Mycobacterium tuberculosis Conserved protein 0.0009 0.0024 0.0073
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0034 0.0034
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0007 0 0.0001
Onchocerca volvulus 0.0007 0.0002 0.0006
Echinococcus multilocularis rhodopsin orphan GPCR 0.0007 0.0002 0.0002
Echinococcus multilocularis g-protein coupled receptor 0.0007 0.0002 0.0002
Plasmodium vivax aldehyde reductase, putative 0.0009 0.0024 0.0073
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.2753 0.8317
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0109 0.1145 0.3458
Brugia malayi hypothetical protein 0.0007 0.0002 0.0002
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0183 0.0554
Brugia malayi RNA binding protein 0.0062 0.0613 0.0613
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0007 0 0.0001
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0183 0.0554
Onchocerca volvulus 0.0007 0.0002 0.0006
Leishmania major aldo-keto reductase-like protein 0.0031 0.0271 0.0818
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0253 0.2753 0.2753
Echinococcus multilocularis g protein coupled receptor 0.0007 0.0002 0.0002
Brugia malayi Dopamine receptor protein 1 0.0007 0.0002 0.0002
Echinococcus granulosus rhodopsin orphan GPCR 0.0007 0.0002 0.0002
Echinococcus granulosus tm gpcr rhodopsin 0.0007 0.0002 0.0002
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0119 0.1253 0.3785
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0002
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0109 0.1145 0.3458
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0183 0.0183
Onchocerca volvulus 0.0031 0.0271 0.0818
Onchocerca volvulus 0.0007 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0002
Echinococcus granulosus dro:myosuppressin receptor 0.0007 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0002
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0183 0.0554
Schistosoma mansoni neuropeptide receptor 0.0007 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0017 0.0118 0.0118
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0152 0.1626 0.1626
Echinococcus granulosus neuropeptide receptor 0.0007 0.0002 0.0002
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0271 0.0818
Loa Loa (eye worm) hypothetical protein 0.0017 0.0118 0.0118
Echinococcus multilocularis aldo keto reductase 0.0031 0.0271 0.0271
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0613 0.0613
Brugia malayi hypothetical protein 0.0007 0.0002 0.0002
Brugia malayi Fibronectin type III domain containing protein 0.0009 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0097 0.1012 0.1012
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0034 0.0034
Schistosoma mansoni nuclear hormone receptor 0.001 0.0034 0.0034
Echinococcus granulosus rhodopsin orphan GPCR 0.0007 0.0002 0.0002
Echinococcus multilocularis aldehyde reductase 0.0022 0.017 0.017
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0007 0 0.0001
Schistosoma mansoni hypothetical protein 0.0066 0.0668 0.0668
Echinococcus multilocularis aurora kinase A 0.0109 0.1145 0.1145
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0009 0.0024 0.0024
Echinococcus granulosus defective proboscis extension response 0.0009 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0002
Onchocerca volvulus 0.0007 0.0002 0.0006
Onchocerca volvulus 0.0031 0.0271 0.0818
Leishmania major prostaglandin f synthase, putative 0.0031 0.0271 0.0818
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0183 0.0554
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0007 0 0.0001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0002 0.0002
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0002
Brugia malayi G-protein coupled receptor 0.0007 0.0002 0.0002
Echinococcus granulosus neuroligin 0.0152 0.1626 0.1626
Echinococcus multilocularis Immunoglobulin 0.0009 0.0024 0.0024
Brugia malayi serine/threonine protein kinase 6 0.0109 0.1145 0.1145
Schistosoma mansoni hypothetical protein 0.0007 0.0002 0.0002
Brugia malayi Immunoglobulin I-set domain containing protein 0.0146 0.156 0.156
Loa Loa (eye worm) hypothetical protein 0.0152 0.1626 0.1626
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0152 0.1626 0.4914
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0007 0 0.0001
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0271 0.0271
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0007 0 0.0001
Entamoeba histolytica hypothetical protein 0.0035 0.0315 0.0953
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0024 0.0073
Echinococcus granulosus tar DNA binding protein 0.0062 0.0613 0.0613
Echinococcus multilocularis rhodopsin orphan GPCR 0.0007 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.001 0.0034 0.0034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0034 0.0034
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0002 0.0002
Echinococcus granulosus neuropeptide Y receptor 0.0007 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0002
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0007 0.0002 0.0002
Schistosoma mansoni thyroid hormone receptor 0.001 0.0034 0.0034
Echinococcus multilocularis neuroligin 0.0152 0.1626 0.1626
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.1012 0.1012
Echinococcus multilocularis somatostatin receptor 0.0007 0.0002 0.0002
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.2753 0.8317
Echinococcus multilocularis orexin receptor type 2 0.0007 0.0002 0.0002
Echinococcus multilocularis carboxylesterase 5A 0.09 1 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0002
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0007 0 0.0001
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0034 0.0034
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0271 0.0271
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.178 0.5378
Brugia malayi serine/threonine kinase 12 0.0109 0.1145 0.1145
Loa Loa (eye worm) carboxylesterase 0.09 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0425 0.0425
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0613 0.0613
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0271 0.0271
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0007 0.0002 0.0002
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0007 0.0002 0.0002
Onchocerca volvulus 0.0133 0.1417 0.4281
Schistosoma mansoni amine GPCR 0.0007 0.0002 0.0002
Schistosoma mansoni aldo-keto reductase 0.0031 0.0271 0.0271
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.2753 0.8317
Brugia malayi hypothetical protein 0.0007 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0031 0.0268 0.0268
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0031 0.0271 0.0818
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0315 0.0315
Mycobacterium leprae Conserved hypothetical protein 0.0007 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0002
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0007 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0002
Trypanosoma cruzi aldo/keto reductase, putative 0.0009 0.0024 0.0073
Echinococcus granulosus neuropeptides capa receptor 0.0007 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0002
Trichomonas vaginalis aldo/keto reductase, putative 0.0031 0.0271 0.0818
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0107 0.0324
Echinococcus multilocularis neuropeptide Y receptor 0.0007 0.0002 0.0002
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.0668 0.0668
Entamoeba histolytica hypothetical protein 0.0035 0.0315 0.0953
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0425 0.0425
Trichomonas vaginalis AGC family protein kinase 0.0109 0.1145 0.3458
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0613 0.0613
Entamoeba histolytica protein kinase, putative 0.0109 0.1145 0.3458
Onchocerca volvulus 0.0007 0.0002 0.0006
Entamoeba histolytica aldose reductase, putative 0.0031 0.0271 0.0818
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0007 0.0002 0.0002
Echinococcus granulosus carboxylesterase 5A 0.09 1 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0183 0.0554
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0271 0.0271
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0107 0.0324
Mycobacterium leprae Possible oxidoreductase 0.0009 0.0024 0.0073
Loa Loa (eye worm) hypothetical protein 0.0009 0.0024 0.0024
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0425 0.0425
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0007 0 0.0001
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0146 0.156 0.156
Loa Loa (eye worm) hypothetical protein 0.0014 0.0083 0.0083
Echinococcus multilocularis para nitrobenzyl esterase 0.0152 0.1626 0.1626
Onchocerca volvulus 0.0152 0.1626 0.4914
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0183 0.0554
Brugia malayi Dopamine receptor 0.0007 0.0002 0.0002
Onchocerca volvulus 0.0031 0.0271 0.0818
Echinococcus granulosus orexin receptor type 2 0.0007 0.0002 0.0002
Wolbachia endosymbiont of Brugia malayi thymidylate kinase 0.0302 0.331 0.5
Echinococcus granulosus neuropeptide FF receptor 2 0.0007 0.0002 0.0002
Onchocerca volvulus 0.0007 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0017 0.0118 0.0118
Echinococcus multilocularis rhodopsin orphan GPCR 0.0007 0.0002 0.0002
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0034 0.0034
Schistosoma mansoni amine GPCR 0.0007 0.0002 0.0002
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0152 0.1626 0.4914
Brugia malayi hypothetical protein 0.0007 0.0002 0.0002
Onchocerca volvulus 0.0007 0.0002 0.0006
Brugia malayi nuclear receptor NHR-88 0.001 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0002
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0271 0.0271
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0425 0.0425
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0007 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0302 0.331 0.331
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0271 0.0271
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0034 0.0034
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0031 0.0271 0.0818
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0271 0.0271
Loa Loa (eye worm) hypothetical protein 0.0152 0.1626 0.1626
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0034 0.0034
Entamoeba histolytica hypothetical protein 0.0035 0.0315 0.0953
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0002 0.0002
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0007 0 0.0001
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0007 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0002
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0034 0.0034
Schistosoma mansoni neuropeptide receptor 0.0007 0.0002 0.0002
Brugia malayi thymidylate kinase 0.0302 0.331 0.331
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0034 0.0034
Echinococcus multilocularis GPCR, family 2 0.0031 0.0268 0.0268
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0009 0.0024 0.0024
Schistosoma mansoni neuropeptide receptor 0.0007 0.0002 0.0002
Trichomonas vaginalis AGC family protein kinase 0.0109 0.1145 0.3458
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0034 0.0034
Trichomonas vaginalis AGC family protein kinase 0.0109 0.1145 0.3458
Loa Loa (eye worm) hypothetical protein 0.0009 0.0024 0.0024
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0152 0.1626 0.4914
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0183 0.0554
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.1012 0.1012
Onchocerca volvulus 0.0007 0.0002 0.0006
Echinococcus granulosus alpha 1A adrenergic receptor 0.0007 0.0002 0.0002
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0007 0.0002 0.0002
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0268 0.0268
Loa Loa (eye worm) hypothetical protein 0.001 0.0034 0.0034
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0183 0.0183
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0031 0.0271 0.0818
Loa Loa (eye worm) hypothetical protein 0.09 1 1
Brugia malayi AKH receptor 0.0007 0.0002 0.0002
Mycobacterium ulcerans thymidylate kinase 0.0302 0.331 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0002 0.0002
Toxoplasma gondii aurora kinase 0.0109 0.1145 0.3458
Echinococcus multilocularis rhodopsin orphan GPCR 0.0007 0.0002 0.0002
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0109 0.1145 0.3458
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0009 0.0024 0.0024
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0613 0.0613
Entamoeba histolytica protein kinase , putative 0.0109 0.1145 0.3458
Loa Loa (eye worm) AUR protein kinase 0.0109 0.1145 0.1145
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0002
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0009 0.0024 0.0073
Brugia malayi Serotonin receptor 0.0007 0.0002 0.0002
Brugia malayi hypothetical protein 0.0035 0.0315 0.0315
Schistosoma mansoni opsin-like receptor 0.0007 0.0002 0.0002
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0268 0.0268
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0002 0.0002
Schistosoma mansoni adenoreceptor 0.0007 0.0002 0.0002
Echinococcus granulosus aldo keto reductase 0.0031 0.0271 0.0271
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0034 0.0034
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0271 0.0818
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0183 0.0554
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0007 0.0002 0.0002
Echinococcus multilocularis neuropeptide FF receptor 2 0.0007 0.0002 0.0002
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0007 0.0002 0.0002
Echinococcus multilocularis aldo keto reductase 0.0031 0.0271 0.0271
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0034 0.0034
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0034 0.0034
Entamoeba histolytica alcohol dehydrogenase, putative 0.0009 0.0024 0.0073
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0034 0.0034
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0009 0.0024 0.0024
Echinococcus granulosus g-protein coupled receptor 0.0007 0.0002 0.0002
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0271 0.0271
Leishmania major cytochrome p450-like protein 0.0007 0 0.0001
Trichomonas vaginalis AGC family protein kinase 0.0109 0.1145 0.3458
Echinococcus multilocularis sex peptide receptor 0.0007 0.0002 0.0002
Echinococcus granulosus twitchin 0.0012 0.006 0.006
Trichomonas vaginalis thymidylate kinase, putative 0.0302 0.331 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0118 0.0356
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0152 0.1626 0.1626
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0009 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0009 0.0024 0.0024
Schistosoma mansoni protein kinase 0.0109 0.1145 0.1145
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0118 0.0356
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0007 0.0002 0.0002
Trypanosoma cruzi aldo-keto reductase 0.0031 0.0271 0.0818
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0002
Echinococcus granulosus FTZ F1 alpha 0.001 0.0034 0.0034
Brugia malayi TAR-binding protein 0.0062 0.0613 0.0613
Loa Loa (eye worm) AUR protein kinase 0.0109 0.1145 0.1145
Schistosoma mansoni neuropeptide F-like receptor 0.0007 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0152 0.1626 0.1626
Schistosoma mansoni neuroligin 3 (S09 family) 0.0152 0.1626 0.1626
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0024 0.0073
Echinococcus granulosus acetylcholinesterase 0.09 1 1
Mycobacterium ulcerans carboxylesterase, LipT 0.0152 0.1626 0.4914
Brugia malayi Carboxylesterase family protein 0.0152 0.1626 0.1626
Brugia malayi NADH-dependent xylose reductase 0.0009 0.0024 0.0024
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0007 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0002
Echinococcus granulosus aurora kinase A 0.0109 0.1145 0.1145
Echinococcus multilocularis neuroglian 0.0011 0.005 0.005
Mycobacterium tuberculosis Carboxylesterase LipT 0.0152 0.1626 0.4914
Loa Loa (eye worm) oxidoreductase 0.0031 0.0271 0.0271
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0002
Brugia malayi hypothetical protein 0.0007 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0002
Echinococcus granulosus aldehyde reductase 0.0022 0.017 0.017
Echinococcus granulosus Immunoglobulin 0.0009 0.0024 0.0024
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0007 0 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0017 0.0118 0.0118
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0007 0 0.0001
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0268 0.0268
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0007 0 0.0001
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0034 0.0034
Brugia malayi Immunoglobulin I-set domain containing protein 0.0009 0.0024 0.0024
Toxoplasma gondii aldo-keto reductase 0.0009 0.0024 0.0073
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0425 0.0425
Echinococcus multilocularis allatostatin A receptor 0.0007 0.0002 0.0002
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.178 0.5378
Trypanosoma cruzi thymidylate kinase, putative 0.0302 0.331 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0057
Onchocerca volvulus 0.0152 0.1626 0.4914
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0271 0.0271
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0031 0.0271 0.0818
Trypanosoma brucei prostaglandin f synthase 0.0031 0.0271 0.0818
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0034 0.0034
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0007 0 0.0001
Loa Loa (eye worm) oxidoreductase 0.0031 0.0271 0.0271
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0271 0.0818
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0031 0.0271 0.0271
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0183 0.0554
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0002
Onchocerca volvulus Neuropeptide F receptor homolog 0.0007 0.0002 0.0006
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0007 0.0002 0.0002
Trichomonas vaginalis spcc417.12 protein, putative 0.0152 0.1626 0.4914
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0007 0 0.0001
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0007 0 0.0001
Brugia malayi putative neuropeptide receptor 0.0007 0.0002 0.0002
Onchocerca volvulus 0.0009 0.0024 0.0073
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0007 0.0002 0.0002
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0007 0.0002 0.0002
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0271 0.0271
Echinococcus multilocularis g protein coupled receptor 0.0007 0.0002 0.0002
Plasmodium falciparum thymidylate kinase 0.0302 0.331 1
Brugia malayi Dopamine receptor protein 2 0.0007 0.0002 0.0002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0107 0.0324
Echinococcus multilocularis aldo keto reductase 0.0031 0.0271 0.0271
Schistosoma mansoni myosin xvIII 0.0007 0.0002 0.0002
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.1012 0.1012
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0268 0.0268
Echinococcus multilocularis neuropeptide Y receptor 0.0007 0.0002 0.0002
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0152 0.1626 0.1626
Loa Loa (eye worm) hypothetical protein 0.001 0.0034 0.0034
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.178 0.5378
Loa Loa (eye worm) hypothetical protein 0.0152 0.1626 0.1626
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0034 0.0034
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.2753 0.8317
Brugia malayi GnHR receptor homolog 0.0007 0.0002 0.0002
Schistosoma mansoni thymidylate kinase 0.0302 0.331 0.331
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0007 0.0002 0.0002
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0034 0.0034
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0183 0.0554
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0031 0.0268 0.0268
Giardia lamblia Aurora kinase 0.0109 0.1145 0.2875
Brugia malayi hypothetical protein 0.0009 0.0024 0.0024
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0007 0.0002 0.0002
Onchocerca volvulus 0.0007 0.0002 0.0006
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0271 0.0271
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0183 0.0554
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0007 0 0.0001
Echinococcus granulosus g protein coupled receptor 0.0007 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0023 0.0183 0.0183
Loa Loa (eye worm) thymidylate kinase 0.0302 0.331 0.331
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0007 0 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0034 0.0034
Plasmodium falciparum serine/threonine protein kinase, putative 0.0109 0.1145 0.3458
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0109 0.1145 0.1145
Echinococcus multilocularis serotonin receptor 0.0007 0.0002 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0034 0.0034
Brugia malayi serine/threonine-protein kinase 6 0.0109 0.1145 0.1145
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.178 0.5378
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0034 0.0034
Echinococcus granulosus biogenic amine 5HT receptor 0.0007 0.0002 0.0002
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0034 0.0034
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0613 0.0613
Mycobacterium ulcerans oxidoreductase 0.0031 0.0271 0.0818
Loa Loa (eye worm) hypothetical protein 0.0009 0.0024 0.0024
Entamoeba histolytica aldose reductase, putative 0.0031 0.0271 0.0818
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0007 0.0002 0.0002
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0034 0.0034
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0007 0.0002 0.0002
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0007 0 0.0001
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0031 0.0271 0.0818
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0007 0 0.0001
Trypanosoma brucei aurora B kinase 0.0109 0.1145 0.3458
Echinococcus multilocularis roundabout 2 0.0014 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0002
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0425 0.0425
Brugia malayi ecdysteroid receptor 0.001 0.0034 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0034 0.0034
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0007 0.0002 0.0002
Schistosoma mansoni pol-related 0.0031 0.0271 0.0271
Mycobacterium ulcerans hypothetical protein 0.0009 0.0024 0.0073
Toxoplasma gondii aldose reductase, putative 0.0031 0.0271 0.0818
Loa Loa (eye worm) neuropeptide F receptor 0.0007 0.0002 0.0002
Leishmania major cytochrome p450-like protein 0.0007 0 0.0001
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0268 0.0268
Echinococcus granulosus hypothetical protein 0.0007 0.0002 0.0002
Schistosoma mansoni gliotactin 0.0152 0.1626 0.1626
Entamoeba histolytica aldose reductase, putative 0.0031 0.0271 0.0818
Echinococcus granulosus aldo keto reductase 0.0031 0.0271 0.0271
Echinococcus granulosus neuropeptide receptor 0.0007 0.0002 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0034 0.0034
Trichomonas vaginalis aldo/keto reductase, putative 0.0031 0.0271 0.0818
Loa Loa (eye worm) melatonin receptor type 1A 0.0007 0.0002 0.0002
Onchocerca volvulus 0.0007 0.0002 0.0006
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0034 0.0034
Schistosoma mansoni nephrin 0.0011 0.005 0.005
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0007 0.0002 0.0002
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0613 0.0613
Plasmodium falciparum aldo-keto reductase, putative 0.0009 0.0024 0.0073
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0007 0 0.0001
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0009 0.0024 0.0073
Onchocerca volvulus 0.0031 0.0271 0.0818
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0002
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0007 0.0002 0.0002
Onchocerca volvulus 0.0152 0.1626 0.4914
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0425 0.0425
Entamoeba histolytica Thymidylate kinase, putative 0.0302 0.331 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0271 0.0271
Echinococcus multilocularis BC026374 protein (S09 family) 0.0152 0.1626 0.1626
Schistosoma mansoni neuropeptide receptor 0.0007 0.0002 0.0002
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0007 0 0.0001
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0007 0 0.0001
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.178 0.5378
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0271 0.0818
Schistosoma mansoni opsin-like receptor 0.0007 0.0002 0.0002
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0007 0.0002 0.0002
Trichomonas vaginalis aldo/keto reductase, putative 0.0031 0.0271 0.0818
Onchocerca volvulus Tyrosine kinase homolog 0.0136 0.1452 0.4387
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.2753 0.8317
Schistosoma mansoni acetylcholinesterase 0.0152 0.1626 0.1626
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0271 0.0271
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0034 0.0034
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0012 0.0057 0.0057
Onchocerca volvulus Putative thymidylate kinase 0.0302 0.331 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0007 0.0002 0.0002
Chlamydia trachomatis thymidylate kinase 0.0302 0.331 1
Loa Loa (eye worm) oxidoreductase 0.0031 0.0271 0.0271
Schistosoma mansoni hypothetical protein 0.0031 0.0268 0.0268
Trypanosoma brucei cytochrome P450, putative 0.0007 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0002
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0007 0.0002 0.0002
Entamoeba histolytica protein kinase domain containing protein 0.0109 0.1145 0.3458
Brugia malayi putative neuropeptide receptor NPR1 0.0007 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0017 0.0118 0.0118
Onchocerca volvulus Glucosylceramidase homolog 0.0166 0.178 0.5378
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.188 0.568
Echinococcus multilocularis voltage gated potassium channel subunit 0.0009 0.0024 0.0024
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0034 0.0034
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0007 0.0002 0.0002
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0613 0.0613
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0007 0 0.0001
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0024 0.0073
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0034 0.0102
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0118 0.0356
Schistosoma mansoni histamine h1 receptor 0.0007 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0002
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0271 0.0818
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0118 0.0356
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0315 0.0315
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0119 0.1253 0.3785
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0007 0 0.0001
Echinococcus granulosus allatostatin A receptor 0.0007 0.0002 0.0002
Echinococcus granulosus neuropeptide receptor A26 0.0007 0.0002 0.0002
Loa Loa (eye worm) oxidoreductase 0.0031 0.0271 0.0271
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0031 0.0271 0.0271
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0271 0.0818
Schistosoma mansoni thymidylate kinase 0.0302 0.331 0.331
Entamoeba histolytica alcohol dehydrogenase, putative 0.0009 0.0024 0.0073
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0002
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.001 0.0034 0.0034
Brugia malayi follicle stimulating hormone receptor 0.0007 0.0002 0.0002
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0031 0.0271 0.0818
Onchocerca volvulus 0.0007 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.001 0.0034 0.0034
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0007 0.0002 0.0002
Echinococcus granulosus BC026374 protein S09 family 0.0152 0.1626 0.1626
Trypanosoma brucei aldo/keto reductase, putative 0.0009 0.0024 0.0073
Echinococcus multilocularis g protein coupled receptor 0.0007 0.0002 0.0002
Onchocerca volvulus 0.0007 0.0002 0.0006
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0007 0 0.0001
Echinococcus granulosus 7tm_1 domain containing protein 0.0007 0.0002 0.0002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0002 0.0002
Brugia malayi Melatonin receptor type 1A 0.0007 0.0002 0.0002
Plasmodium vivax thymidylate kinase, putative 0.0302 0.331 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0002
Brugia malayi hypothetical protein 0.0007 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.001 0.0034 0.0034
Echinococcus granulosus biogenic amine 5HT receptor 0.0007 0.0002 0.0002
Echinococcus multilocularis serotonin receptor 0.0007 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0031 0.0271 0.0271
Echinococcus granulosus GPCR family 2 0.0031 0.0268 0.0268
Brugia malayi G protein-coupled receptor 0.0007 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0002
Schistosoma mansoni biogenic amine (5HT) receptor 0.0007 0.0002 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0034 0.0034
Echinococcus multilocularis G-protein coupled receptor, putative 0.0007 0.0002 0.0002
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0183 0.0554
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0007 0 0.0001
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0034 0.0034
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0107 0.0324
Leishmania major protein kinase, putative 0.0109 0.1145 0.3458
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0007 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0002
Echinococcus granulosus neuropeptide Y receptor 0.0007 0.0002 0.0002
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0007 0 0.0001
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0007 0 0.0001
Echinococcus multilocularis neuropeptide receptor 0.0007 0.0002 0.0002
Loa Loa (eye worm) AUR protein kinase 0.0109 0.1145 0.1145
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0183 0.0554
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0007 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0002
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0007 0.0002 0.0002
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0268 0.0268
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0007 0.0002 0.0002
Schistosoma mansoni amine GPCR 0.0007 0.0002 0.0002
Mycobacterium leprae Conserved hypothetical protein 0.0022 0.017 0.0514
Trypanosoma cruzi aldo/keto reductase, putative 0.0031 0.0271 0.0818
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.188 0.568
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0271 0.0818
Loa Loa (eye worm) hypothetical protein 0.0009 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0023 0.0183 0.0183
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0613 0.0613
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0034 0.0034
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0007 0.0002 0.0002
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0031 0.0271 0.0271
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0002
Echinococcus granulosus acetylcholinesterase 0.09 1 1
Trypanosoma cruzi cytochrome P450, putative 0.0007 0 0.0001
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0009 0.0024 0.0073
Onchocerca volvulus 0.0023 0.0183 0.0554
Brugia malayi Tachykinin-like peptides receptor 99D 0.0007 0.0002 0.0002
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0009 0.0024 0.0024
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0271 0.0818
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0007 0.0002 0.0002
Mycobacterium tuberculosis Probable oxidoreductase 0.0031 0.0271 0.0818
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0007 0 0.0001
Schistosoma mansoni amine GPCR 0.0007 0.0002 0.0002
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0007 0 0.0001
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0007 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0009 0.0024 0.0024
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0268 0.0268
Brugia malayi Carboxylesterase family protein 0.0152 0.1626 0.1626
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0034 0.0034
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0007 0.0002 0.0002
Trypanosoma brucei aldo-keto reductase, putative 0.0031 0.0271 0.0818
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0007 0.0002 0.0002
Echinococcus granulosus neuroglian 0.0011 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0002
Toxoplasma gondii cytochrome p450 superfamily protein 0.0007 0 0.0001
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0271 0.0271
Mycobacterium ulcerans hypothetical protein 0.0023 0.0183 0.0554
Echinococcus granulosus serotonin receptor 0.0007 0.0002 0.0002
Echinococcus granulosus fmrfamide receptor 0.0007 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0152 0.1626 0.1626
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0271 0.0271
Echinococcus granulosus tm gpcr rhodopsin 0.0007 0.0002 0.0002
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0271 0.0271
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0034 0.0034
Echinococcus multilocularis neuropeptides capa receptor 0.0007 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.001 0.0034 0.0034
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0109 0.1145 0.1145
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0007 0 0.0001
Echinococcus multilocularis neuropeptides capa receptor 0.0007 0.0002 0.0002
Trypanosoma cruzi cytochrome P450, putative 0.0007 0 0.0001
Brugia malayi hypothetical protein 0.0007 0.0002 0.0002
Loa Loa (eye worm) G-protein coupled receptor 0.0007 0.0002 0.0002
Echinococcus granulosus rhodopsin orphan GPCR 0.0007 0.0002 0.0002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0183 0.0554
Trichomonas vaginalis thymidylate kinase, putative 0.0302 0.331 1
Schistosoma mansoni hypothetical protein 0.0031 0.0268 0.0268
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0007 0.0002 0.0002
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0034 0.0034
Schistosoma mansoni amine GPCR 0.0007 0.0002 0.0002
Echinococcus granulosus neuropeptide s receptor 0.0007 0.0002 0.0002
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0253 0.2753 0.2753
Loa Loa (eye worm) hypothetical protein 0.0152 0.1626 0.1626
Loa Loa (eye worm) carboxylesterase 0.0152 0.1626 0.1626
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0002
Echinococcus multilocularis acetylcholinesterase 0.09 1 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0007 0.0002 0.0002
Echinococcus granulosus 7TM GPCR rhodopsin 0.0007 0.0002 0.0002
Loa Loa (eye worm) TYRA-2 protein 0.0007 0.0002 0.0002
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.178 0.5378
Loa Loa (eye worm) hypothetical protein 0.0023 0.0183 0.0183
Schistosoma mansoni hypothetical protein 0.0007 0.0002 0.0002
Brugia malayi sulfakinin receptor protein 0.0007 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0002
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0152 0.1626 0.1626
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0002
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.09 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0271 0.0818
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0007 0 0.0001
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0034 0.0034
Echinococcus granulosus hypothetical protein 0.0031 0.0271 0.0271
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0007 0.0002 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0002
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0034 0.0034
Schistosoma mansoni vesicular amine transporter 0.0009 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.0007 0.0002 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0034 0.0034
Echinococcus multilocularis rhodopsin orphan GPCR 0.0007 0.0002 0.0002
Echinococcus granulosus roundabout 2 0.0014 0.0083 0.0083
Echinococcus multilocularis dro:myosuppressin receptor 0.0007 0.0002 0.0002
Brugia malayi Carboxylesterase family protein 0.0152 0.1626 0.1626
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.1145 0.1145
Onchocerca volvulus 0.0007 0.0002 0.0006
Echinococcus multilocularis G protein coupled receptor 139 0.0007 0.0002 0.0002
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0007 0.0002 0.0002
Echinococcus granulosus aldo keto reductase 0.0031 0.0271 0.0271
Echinococcus granulosus rhodopsin orphan GPCR 0.0007 0.0002 0.0002
Loa Loa (eye worm) carboxylesterase 0.0152 0.1626 0.1626
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0034 0.0034
Echinococcus granulosus rhodopsin orphan GPCR 0.0007 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0066 0.0668 0.0668
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0031 0.0271 0.0271
Onchocerca volvulus 0.0031 0.0271 0.0818
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0183 0.0183
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0034 0.0034
Toxoplasma gondii thymidylate kinase 0.0302 0.331 1
Brugia malayi Carboxylesterase family protein 0.0152 0.1626 0.1626
Echinococcus granulosus tachykinin peptides receptor 99D 0.0007 0.0002 0.0002
Echinococcus multilocularis thymidylate kinase 0.0302 0.331 0.331
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0002 0.0002
Brugia malayi hypothetical protein 0.0007 0.0002 0.0002
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0007 0.0002 0.0002
Mycobacterium leprae putative cytochrome p450 0.0007 0 0.0001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0002 0.0002
Trypanosoma cruzi thymidylate kinase, putative 0.0302 0.331 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0007 0.0002 0.0002
Loa Loa (eye worm) oxidoreductase 0.0031 0.0271 0.0271
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0009 0.0024 0.0073
Schistosoma mansoni aldo-keto reductase 0.0031 0.0271 0.0271
Brugia malayi Serotonin receptor 0.0007 0.0002 0.0002
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0007 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0014 0.0083 0.0083
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0007 0 0.0001
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0183 0.0554
Echinococcus granulosus rhodopsin orphan GPCR 0.0007 0.0002 0.0002
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0315 0.0315
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0007 0 0.0001
Schistosoma mansoni thyroid hormone receptor 0.001 0.0034 0.0034
Brugia malayi steroid hormone receptor 0.001 0.0034 0.0034
Schistosoma mansoni alpha-1 adrenergic receptor 0.0007 0.0002 0.0002
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0034 0.0034
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0007 0.0002 0.0006
Echinococcus multilocularis rhodopsin orphan GPCR 0.0007 0.0002 0.0002
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0007 0 0.0001
Onchocerca volvulus 0.0152 0.1626 0.4914
Schistosoma mansoni biogenic amine receptor 0.0007 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0007 0.0002 0.0002
Onchocerca volvulus 0.0031 0.0271 0.0818
Echinococcus multilocularis acetylcholinesterase 0.09 1 1
Plasmodium falciparum aldehyde reductase, putative 0.0009 0.0024 0.0073
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0024 0.0073
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0613 0.0613
Schistosoma mansoni cell adhesion molecule 0.0012 0.0057 0.0057
Leishmania major cytochrome p450-like protein 0.0007 0 0.0001
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0007 0 0.0001
Loa Loa (eye worm) G-protein coupled receptor 0.0007 0.0002 0.0002
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0034 0.0034
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0007 0.0002 0.0002
Echinococcus multilocularis Immunoglobulin 0.0009 0.0024 0.0024
Trypanosoma cruzi aurora B kinase, putative 0.0109 0.1145 0.3458
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0271 0.0818
Brugia malayi ORL1-like opioid receptor 0.0007 0.0002 0.0002
Trypanosoma brucei thymidylate kinase, putative 0.0302 0.331 1
Brugia malayi RE15519p 0.0007 0.0002 0.0002
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0109 0.1145 0.3458
Entamoeba histolytica hypothetical protein 0.0035 0.0315 0.0953
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0034 0.0102
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0007 0 0.0001
Onchocerca volvulus 0.0007 0.0002 0.0006
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0007 0 0.0001
Brugia malayi neuropeptide F receptor 0.0007 0.0002 0.0002
Mycobacterium leprae probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) 0.0302 0.331 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0007 0.0002 0.0002
Schistosoma mansoni biogenic amine receptor 0.0007 0.0002 0.0002
Echinococcus multilocularis neuropeptide s receptor 0.0007 0.0002 0.0002
Schistosoma mansoni opsin-like receptor 0.0007 0.0002 0.0002
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0034 0.0034
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0034 0.0034
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0007 0 0.0001
Onchocerca volvulus 0.0152 0.1626 0.4914
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0793 0.8806 0.8806
Giardia lamblia CDC8 0.0302 0.331 1
Brugia malayi neuropeptide F receptor 0.0007 0.0002 0.0002
Brugia malayi G-protein coupled receptor 0.0007 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0007 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0002
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0183 0.0554
Treponema pallidum thymidylate kinase (tmk) 0.0302 0.331 0.5
Onchocerca volvulus 0.001 0.0034 0.0102
Loa Loa (eye worm) RNA binding protein 0.0062 0.0613 0.0613
Loa Loa (eye worm) hypothetical protein 0.09 1 1
Brugia malayi larval opioid receptor 0.0007 0.0002 0.0002
Schistosoma mansoni BC026374 protein (S09 family) 0.0152 0.1626 0.1626
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0425 0.0425
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0183 0.0554
Schistosoma mansoni growth hormone secretagogue receptor 0.0007 0.0002 0.0002
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0007 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0002
Trypanosoma brucei thymidylate kinase, putative 0.0302 0.331 1
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0007 0 0.0001
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.178 0.5378
Echinococcus granulosus para nitrobenzyl esterase 0.0152 0.1626 0.1626
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0034 0.0102
Schistosoma mansoni coup transcription factor 0.001 0.0034 0.0034
Echinococcus granulosus somatostatin receptor 0.0007 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.001 0.0034 0.0034
Loa Loa (eye worm) neuropeptide F receptor 0.0007 0.0002 0.0002
Echinococcus granulosus thymidylate kinase 0.0302 0.331 0.331
Brugia malayi nuclear hormone receptor 0.001 0.0034 0.0034
Echinococcus multilocularis neuropeptide receptor A26 0.0007 0.0002 0.0002
Echinococcus granulosus rhodopsin orphan GPCR 0.0007 0.0002 0.0002
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0007 0.0002 0.0002
Schistosoma mansoni neuropeptide F-like receptor 0.0007 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0035 0.0315 0.0315
Echinococcus multilocularis fmrfamide receptor 0.0007 0.0002 0.0002
Leishmania major hypothetical protein, conserved 0.0119 0.1253 0.3785
Brugia malayi Carboxylesterase family protein 0.09 1 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0007 0.0002 0.0002
Echinococcus granulosus g protein coupled receptor 0.0007 0.0002 0.0002
Onchocerca volvulus 0.0007 0.0002 0.0006
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0007 0 0.0001
Schistosoma mansoni biogenic amine receptor 0.0007 0.0002 0.0002
Loa Loa (eye worm) acetylcholinesterase 1 0.09 1 1
Echinococcus granulosus neuropeptides capa receptor 0.0007 0.0002 0.0002
Brugia malayi hypothetical protein 0.0007 0.0002 0.0002
Echinococcus granulosus voltage gated potassium channel subunit 0.0009 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0002
Echinococcus granulosus sex peptide receptor 0.0007 0.0002 0.0002
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0271 0.0271
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0271 0.0271
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0271 0.0818
Entamoeba histolytica protein kinase, putative 0.0109 0.1145 0.3458
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0007 0 0.0001
Schistosoma mansoni biogenic amine (5HT) receptor 0.0007 0.0002 0.0002
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0271 0.0271
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0425 0.0425
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0271 0.0818
Onchocerca volvulus 0.0007 0.0002 0.0006
Brugia malayi hypothetical protein 0.0007 0.0002 0.0002
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0007 0 0.0001
Echinococcus granulosus tm gpcr rhodopsin 0.0007 0.0002 0.0002
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0034 0.0034
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0007 0 0.0001
Echinococcus granulosus g protein coupled receptor 0.0007 0.0002 0.0002
Leishmania major thymidylate kinase-like protein 0.0302 0.331 1
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.2753 0.8317
Schistosoma mansoni hypothetical protein 0.0031 0.0268 0.0268
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0034 0.0034
Echinococcus multilocularis neuropeptide receptor 0.0007 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0152 0.1626 0.1626
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0034 0.0034

Activities

Activity type Activity value Assay description Source Reference
Ke (functional) = 1174 nM Antagonist activity at human CB1 receptor expressed in CHO-K1 cells co-expressing Galphaq16 assessed as inhibition of CP55940-induced intracellular calcium mobilization by fluorometry ChEMBL. 22372835

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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