Detailed information for compound 1657616

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 458.38 | Formula: C24H25Cl2N3O2
  • H donors: 0 H acceptors: 2 LogP: 5.68 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)c1c2OCCCC(c2nn1c1ccccc1Cl)N(C(=O)C(C)C)C
  • InChi: 1S/C24H25Cl2N3O2/c1-15(2)24(30)28(3)20-9-6-14-31-23-21(20)27-29(19-8-5-4-7-18(19)26)22(23)16-10-12-17(25)13-11-16/h4-5,7-8,10-13,15,20H,6,9,14H2,1-3H3
  • InChiKey: BAXLEFIQPNPUNQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cannabinoid receptor 1 (brain) Starlite/ChEMBL References
Homo sapiens cannabinoid receptor 2 (macrophage) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major beta tubulin 0.0136 0.0652 0.2303
Schistosoma mansoni ran 0.0023 0.0046 0.0107
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0274 0.1573
Trichomonas vaginalis glutaminase, putative 0.0282 0.1429 1
Schistosoma mansoni tyrosinase precursor 0.0188 0.0927 0.215
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0029 0.003
Echinococcus multilocularis geminin 0.0337 0.1725 0.1903
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.0911 0.63
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0188 0.0927 0.127
Trichomonas vaginalis tubulin gamma chain, putative 0.0136 0.0652 0.4447
Echinococcus granulosus tar DNA binding protein 0.0065 0.0274 0.0635
Brugia malayi beta-tubulin, identical 0.0136 0.0652 0.089
Loa Loa (eye worm) tubulin alpha-3 chain 0.0176 0.0864 0.5059
Schistosoma mansoni hypothetical protein 0.0023 0.0048 0.011
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0188 0.025
Echinococcus granulosus tubulin beta 4A class IVa 0.0136 0.0652 0.1511
Entamoeba histolytica hypothetical protein 0.0037 0.0121 0.0739
Brugia malayi Tubulin beta-1 chain 0.0136 0.0652 0.089
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0021 0.5
Brugia malayi PXA domain containing protein 0.002 0.0029 0.003
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0274 0.0635
Brugia malayi Telomerase reverse transcriptase 0.1369 0.7248 1
Giardia lamblia Kinase, PLK 0.0097 0.0444 0.1512
Entamoeba histolytica tubulin gamma chain 0.0136 0.0652 0.4991
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1709 0.9064 1
Echinococcus granulosus Tubulin alpha 1 chain 0.0253 0.1276 0.296
Echinococcus multilocularis importin subunit beta 1 0.0031 0.009 0.0099
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0029 0.0067
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0046 0.0107
Echinococcus granulosus expressed protein 0.0384 0.1979 0.4591
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.1352 0.9448
Schistosoma mansoni hypothetical protein 0.0042 0.0147 0.0342
Echinococcus granulosus tubulin beta 1 chain 0.0136 0.0652 0.1511
Schistosoma mansoni tyrosinase precursor 0.0188 0.0927 0.215
Loa Loa (eye worm) tubulin alpha 2 0.0194 0.096 0.5624
Trypanosoma brucei beta tubulin 0.0136 0.0652 0.2303
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.024 0.1504
Trypanosoma brucei beta tubulin 0.0136 0.0652 0.2303
Leishmania major beta tubulin 0.0136 0.0652 0.2303
Echinococcus granulosus tubulin alpha 0.0136 0.0652 0.1511
Trichomonas vaginalis tubulin beta chain, putative 0.0253 0.1276 0.8909
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0142 0.0681 0.093
Echinococcus granulosus tubulin alpha chain 0.0253 0.1276 0.296
Trypanosoma brucei alpha tubulin 0.0253 0.1276 0.4678
Plasmodium vivax tubulin alpha chain, putative 0.0253 0.1276 0.4729
Echinococcus multilocularis Tubulin alpha 1 chain 0.0253 0.1276 0.1408
Echinococcus granulosus tubulin alpha chain 0.0253 0.1276 0.296
Echinococcus multilocularis Tubulin alpha 1 chain 0.0253 0.1276 0.1408
Loa Loa (eye worm) tubulin gamma chain 0.0136 0.0652 0.3803
Echinococcus multilocularis beta tubulin 0.0136 0.0652 0.0719
Schistosoma mansoni tubulin subunit delta 0.0059 0.024 0.0556
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0097 0.0444 0.049
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0029 0.003
Echinococcus multilocularis tubulin alpha 3 chain 0.0253 0.1276 0.1408
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.008
Echinococcus granulosus Tubulin beta 2C chain 0.0136 0.0652 0.1511
Mycobacterium tuberculosis Cell division protein FtsZ 0.0059 0.024 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.008
Trichomonas vaginalis tubulin beta chain, putative 0.0136 0.0652 0.4447
Loa Loa (eye worm) tubulin alpha 2 0.0117 0.0548 0.3193
Brugia malayi hypothetical protein 0.0052 0.02 0.0266
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0194 0.096 0.6651
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0054 0.0198
Loa Loa (eye worm) hypothetical protein 0.0066 0.0276 0.1584
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0007 0.0008
Brugia malayi Importin beta-1 subunit 0.0031 0.009 0.0114
Loa Loa (eye worm) hypothetical protein 0.0176 0.0864 0.5059
Loa Loa (eye worm) glutaminase 2 0.0282 0.1429 0.8391
Brugia malayi CHE-14 protein 0.0043 0.0156 0.0205
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0019 0.0044
Loa Loa (eye worm) tubulin beta chain 0.0059 0.024 0.1372
Trypanosoma brucei polo-like protein kinase 0.0097 0.0444 0.1512
Giardia lamblia Telomerase catalytic subunit 0.0515 0.2676 1
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.02 0.0675
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0253 0.1276 0.8909
Trichomonas vaginalis tubulin alpha chain, putative 0.0077 0.0335 0.2189
Echinococcus multilocularis tubulin epsilon chain 0.0136 0.0652 0.0719
Mycobacterium ulcerans cell division protein FtsZ 0.0059 0.024 0.1554
Leishmania major gamma-tubulin 0.0136 0.0652 0.2303
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0029 0.0032
Brugia malayi tubulin alpha-2 chain 0.0253 0.1276 0.1753
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0054 0.0234
Leishmania major zeta tubulin, putative 0.0059 0.024 0.0736
Schistosoma mansoni tubulin subunit alpha 0.0253 0.1276 0.296
Echinococcus multilocularis protein dispatched 1 0.005 0.0188 0.0208
Trypanosoma brucei beta tubulin 0.0136 0.0652 0.2303
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.0681 0.0751
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0444 0.2962
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0274 0.0302
Leishmania major telomerase reverse transcriptase, putative 0.0515 0.2676 1
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0029 0.0067
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0156 0.0172
Giardia lamblia Beta tubulin 0.0136 0.0652 0.2303
Echinococcus multilocularis tubulin gamma 1 chain 0.0136 0.0652 0.0719
Brugia malayi RNA binding protein 0.0065 0.0274 0.0368
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0136 0.0652 0.2303
Loa Loa (eye worm) tubulin beta-1 chain 0.0136 0.0652 0.3803
Loa Loa (eye worm) RNA binding protein 0.0065 0.0274 0.1573
Trypanosoma brucei epsilon tubulin 0.0136 0.0652 0.2303
Onchocerca volvulus 0.0188 0.0927 0.0878
Echinococcus multilocularis tubulin alpha chain 0.0253 0.1276 0.1408
Trypanosoma brucei zeta tubulin, putative 0.0059 0.024 0.0736
Entamoeba histolytica serine/threonine protein kinase, putative 0.0097 0.0444 0.3325
Leishmania major alpha tubulin 0.0253 0.1276 0.4678
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0274 0.0635
Echinococcus multilocularis Tubulin beta 2C chain 0.0136 0.0652 0.0719
Toxoplasma gondii RNA-directed DNA polymerase 0.0515 0.2676 1
Loa Loa (eye worm) hypothetical protein 0.0188 0.0927 0.5427
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0031 0.0139
Trypanosoma cruzi epsilon tubulin, putative 0.0136 0.0652 0.2303
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.1352 0.9448
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0048 0.0052
Echinococcus granulosus cpg binding protein 0.0061 0.0249 0.0578
Schistosoma mansoni tubulin subunit beta 0.0136 0.0652 0.1511
Echinococcus multilocularis transient receptor potential ion channel A 0.0101 0.0465 0.0514
Echinococcus multilocularis Tubulin beta 2C chain 0.0136 0.0652 0.0719
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0046 0.0051
Echinococcus granulosus tubulin alpha 3 chain 0.0253 0.1276 0.296
Schistosoma mansoni regulator of G protein signaling 0.002 0.0029 0.0067
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0019 0.0021
Onchocerca volvulus Glucosylceramidase homolog 0.0175 0.0861 0.0811
Trichomonas vaginalis tubulin alpha chain, putative 0.0136 0.0652 0.4447
Trypanosoma brucei tubulin gamma chain 0.0136 0.0652 0.2303
Giardia lamblia Delta tubulin 0.0059 0.024 0.0736
Leishmania major alpha tubulin 0.0253 0.1276 0.4678
Giardia lamblia Epsilon tubulin 0.0059 0.024 0.0736
Leishmania major beta tubulin 0.0136 0.0652 0.2303
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0104 0.0134
Brugia malayi serine/threonine-protein kinase plk-2 0.0097 0.0444 0.0603
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0129
Loa Loa (eye worm) alpha-tubulin 0.0253 0.1276 0.749
Echinococcus multilocularis transient receptor potential gamma protein 0.0105 0.0484 0.0534
Giardia lamblia Beta tubulin 0.0136 0.0652 0.2303
Trypanosoma brucei beta tubulin 0.0136 0.0652 0.2303
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0031 0.0071
Echinococcus multilocularis snurportin 1 0.0332 0.1702 0.1877
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0054 0.0234
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0101 0.0465 0.3491
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.0681 0.1579
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0444 0.1029
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0029 0.003
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0059 0.0211
Schistosoma mansoni ran 0.0023 0.0046 0.0107
Echinococcus granulosus tubulin alpha 1C chain 0.0253 0.1276 0.296
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0059 0.024 0.0736
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.0681 0.1579
Loa Loa (eye worm) beta-tubulin 0.0136 0.0652 0.3803
Trichomonas vaginalis ran, putative 0.0023 0.0046 0.0122
Echinococcus multilocularis Tubulin beta 2C chain 0.0136 0.0652 0.0719
Plasmodium falciparum alpha tubulin 1 0.0253 0.1276 0.4729
Schistosoma mansoni transient receptor potential channel 0.0069 0.0294 0.0683
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0029 0.0032
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0031 0.0071
Echinococcus granulosus tubulin alpha chain 0.0253 0.1276 0.296
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0029 0.0032
Leishmania major alpha tubulin 0.0253 0.1276 0.4678
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0861 0.594
Loa Loa (eye worm) hypothetical protein 0.0039 0.0132 0.0736
Loa Loa (eye worm) hypothetical protein 0.0031 0.009 0.0489
Schistosoma mansoni hypothetical protein 0.082 0.4311 1
Leishmania major hypothetical protein, conserved 0.0052 0.02 0.0586
Echinococcus granulosus tubulin alpha chain 0.0253 0.1276 0.296
Mycobacterium ulcerans glutaminase 0.0282 0.1429 1
Brugia malayi Tubulin alpha-2 chain 0.0253 0.1276 0.1753
Trypanosoma brucei alpha tubulin 0.0253 0.1276 0.4678
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0444 0.2962
Plasmodium vivax delta tubulin, putative 0.0059 0.024 0.0824
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.009 0.0167
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.008
Plasmodium vivax tubulin epsilon chain, putative 0.0136 0.0652 0.2376
Leishmania major beta tubulin 0.0136 0.0652 0.2303
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0188 0.0927 0.127
Echinococcus granulosus transient receptor potential gamma protein 0.0105 0.0484 0.1123
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0054 0.0234
Schistosoma mansoni regulator of G protein signaling 0.002 0.0029 0.0067
Echinococcus multilocularis short transient receptor potential channel 6 0.0069 0.0294 0.0325
Echinococcus multilocularis Tubulin beta 2C chain 0.0136 0.0652 0.0719
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.008
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0059 0.024 0.1504
Echinococcus granulosus beta tubulin 0.0136 0.0652 0.1511
Trypanosoma brucei epsilon tubulin 0.0136 0.0652 0.2303
Brugia malayi Tubulin beta chain 0.0077 0.0335 0.0453
Schistosoma mansoni hypothetical protein 0.0337 0.1725 0.4001
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0021 0.0237
Loa Loa (eye worm) tubulin beta-2A chain 0.0136 0.0652 0.3803
Entamoeba histolytica tubulin family protein 0.0136 0.0652 0.4991
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0007 0.0017
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.0681 0.1579
Schistosoma mansoni hypothetical protein 0.0016 0.0007 0.0017
Trypanosoma brucei alpha tubulin 0.0253 0.1276 0.4678
Leishmania major delta tubulin, putative 0.0059 0.024 0.0736
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0054 0.0029
Schistosoma mansoni cpg binding protein 0.0061 0.0249 0.0578
Brugia malayi hypothetical protein 0.002 0.0029 0.003
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0054 0.1707
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0121 0.0134
Plasmodium vivax importin-beta 2, putative 0.0031 0.009 0.0261
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0097 0.0444 0.2576
Schistosoma mansoni regulator of G protein signaling 0.002 0.0029 0.0067
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0046 0.0095
Trypanosoma cruzi zeta tubulin, putative 0.0059 0.024 0.0736
Echinococcus multilocularis expressed conserved protein 0.0095 0.0432 0.0476
Treponema pallidum cell division protein FtsZ 0.0059 0.024 0.5
Echinococcus multilocularis Niemann Pick C1 protein 0.0101 0.0465 0.0512
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0188 0.1068
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0274 0.0635
Plasmodium falciparum tubulin beta chain 0.0136 0.0652 0.2376
Trichomonas vaginalis tubulin epsilon chain, putative 0.0136 0.0652 0.4447
Echinococcus granulosus expressed conserved protein 0.0095 0.0432 0.1001
Echinococcus multilocularis tubulin beta 1 chain 0.0136 0.0652 0.0719
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0054 0.0234
Toxoplasma gondii beta-tubulin, putative 0.0136 0.0652 0.2303
Schistosoma mansoni tubulin subunit beta 0.0059 0.024 0.0556
Schistosoma mansoni patched 1 0.0043 0.0156 0.0361
Leishmania major beta tubulin 0.0136 0.0652 0.2303
Schistosoma mansoni hypothetical protein 0.0016 0.0007 0.0017
Leishmania major alpha tubulin 0.0253 0.1276 0.4678
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0054 0.0064
Schistosoma mansoni tubulin subunit beta 0.0136 0.0652 0.1511
Echinococcus granulosus tubulin subunit TubB 0.0253 0.1276 0.296
Schistosoma mansoni transient receptor potential channel 0.0105 0.0484 0.1123
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.0444 0.1512
Loa Loa (eye worm) hypothetical protein 0.0049 0.0188 0.1068
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.024 0.1504
Brugia malayi Transient-receptor-potential like protein 0.0039 0.0132 0.0172
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0029 0.0067
Brugia malayi TAR-binding protein 0.0065 0.0274 0.0368
Schistosoma mansoni hypothetical protein 0.0016 0.0007 0.0017
Entamoeba histolytica hypothetical protein 0.0037 0.0121 0.0739
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0861 0.594
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0274 0.0368
Schistosoma mansoni importin beta-1 0.0031 0.009 0.0209
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.1352 0.9448
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0029 0.0067
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0031 0.0034
Onchocerca volvulus 0.0188 0.0927 0.0878
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0029 0.0032
Schistosoma mansoni tubulin subunit alpha 0.0059 0.024 0.0556
Loa Loa (eye worm) hypothetical protein 0.0053 0.0208 0.1184
Echinococcus granulosus tubulin alpha 1C chain 0.0253 0.1276 0.296
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0156 0.0361
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.008
Echinococcus granulosus tubulin delta chain 0.0059 0.024 0.0556
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0059 0.024 0.0736
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0274 0.0635
Trypanosoma cruzi alpha tubulin, putative 0.0253 0.1276 0.4678
Echinococcus granulosus tubulin alpha 3 chain 0.0253 0.1276 0.296
Echinococcus granulosus importin subunit beta 1 0.0031 0.009 0.0209
Trypanosoma brucei telomerase reverse transcriptase 0.0515 0.2676 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0253 0.1276 0.8909
Toxoplasma gondii beta-1 tubulin, putative 0.0136 0.0652 0.2303
Loa Loa (eye worm) hypothetical protein 0.0194 0.096 0.5624
Schistosoma mansoni tubulin subunit gamma 0.0136 0.0652 0.1511
Leishmania major beta tubulin 0.0136 0.0652 0.2303
Echinococcus multilocularis cpg binding protein 0.0061 0.0249 0.0275
Schistosoma mansoni hypothetical protein 0.0332 0.1702 0.3947
Echinococcus multilocularis short transient receptor potential channel 6 0.0069 0.0294 0.0325
Trypanosoma brucei alpha tubulin, putative 0.0077 0.0335 0.1101
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0054 0.0234
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0054 0.0234
Plasmodium vivax tubulin beta chain, putative 0.0136 0.0652 0.2376
Loa Loa (eye worm) tyrosinase 1 0.0188 0.0927 0.5427
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0054 0.0234
Onchocerca volvulus 0.0188 0.0927 0.0878
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.0681 0.0751
Schistosoma mansoni axis inhibition protein axin 0.002 0.0029 0.0067
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0861 0.594
Trypanosoma cruzi epsilon tubulin, putative 0.0136 0.0652 0.2303
Trichomonas vaginalis tubulin alpha chain, putative 0.0077 0.0335 0.2189
Entamoeba histolytica hypothetical protein 0.0037 0.0121 0.0739
Leishmania major beta tubulin 0.0136 0.0652 0.2303
Echinococcus multilocularis tubulin subunit beta 0.0136 0.0652 0.0719
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0046 0.0095
Trypanosoma cruzi zeta tubulin, putative 0.0059 0.024 0.0736
Loa Loa (eye worm) hypothetical protein 0.0043 0.0156 0.0876
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0031 0.0139
Giardia lamblia Beta tubulin 0.0136 0.0652 0.2303
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.02 0.0586
Giardia lamblia Alpha-tubulin 0.0253 0.1276 0.4678
Echinococcus multilocularis tubulin alpha 3 chain 0.0253 0.1276 0.1408
Brugia malayi hypothetical protein 0.0037 0.0121 0.0157
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0029 0.0067
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0129
Leishmania major beta tubulin 0.0136 0.0652 0.2303
Trichomonas vaginalis tubulin, putative 0.0077 0.0335 0.2189
Schistosoma mansoni hypothetical protein 0.0042 0.0147 0.0342
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0275
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0176 0.0864 0.5967
Echinococcus multilocularis Tubulin beta 2C chain 0.0136 0.0652 0.0719
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0059 0.0211
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0029 0.0129
Schistosoma mansoni transient receptor potential channel 4 0.0105 0.0484 0.1123
Onchocerca volvulus 0.0058 0.0232 0.0179
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0046 0.0229
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.0681 0.1579
Loa Loa (eye worm) ShTK domain-containing protein 0.0188 0.0927 0.5427
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.0911 0.63
Echinococcus granulosus transient receptor potential ion channel A 0.0101 0.0465 0.108
Schistosoma mansoni hypothetical protein 0.0042 0.0147 0.0342
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0275
Loa Loa (eye worm) BEN-1 protein 0.0136 0.0652 0.3803
Loa Loa (eye worm) hypothetical protein 0.0052 0.02 0.1138
Entamoeba histolytica tubulin alpha chain, putative 0.0253 0.1276 1
Loa Loa (eye worm) tubulin alpha chain 0.0253 0.1276 0.749
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0054 0.0029
Brugia malayi alpha-tubulin 0.0253 0.1276 0.1753
Brugia malayi PXA domain containing protein 0.002 0.0029 0.003
Loa Loa (eye worm) tubulin alpha chain 0.0253 0.1276 0.749
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0029 0.0032
Trypanosoma cruzi tubulin gamma chain 0.0136 0.0652 0.2303
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0129
Loa Loa (eye worm) hypothetical protein 0.0101 0.0465 0.2699
Leishmania major beta tubulin 0.0136 0.0652 0.2303
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.02 0.0586
Leishmania major alpha tubulin 0.0253 0.1276 0.4678
Echinococcus multilocularis tubulin alpha chain 0.0253 0.1276 0.1408
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0054 0.0064
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0274 0.1573
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0046 0.0054
Echinococcus granulosus Tubulin beta 2C chain 0.0136 0.0652 0.1511
Trichomonas vaginalis tubulin epsilon chain, putative 0.0059 0.024 0.1504
Echinococcus granulosus Tubulin beta 2C chain 0.0136 0.0652 0.1511
Toxoplasma gondii histone lysine methyltransferase SET1 0.0109 0.0507 0.1753
Loa Loa (eye worm) hypothetical protein 0.0253 0.1276 0.749
Leishmania major beta tubulin 0.0136 0.0652 0.2303
Plasmodium falciparum alpha tubulin 2 0.0253 0.1276 0.4729
Echinococcus multilocularis tubulin subunit TubB 0.0253 0.1276 0.1408
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0029 0.0032
Echinococcus multilocularis Tubulin alpha 1 chain 0.0253 0.1276 0.1408
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0129
Toxoplasma gondii beta tubulin 0.0136 0.0652 0.2303
Mycobacterium ulcerans hypothetical protein 0.0024 0.0054 0.0234
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.1352 0.9448
Leishmania major beta tubulin 0.0136 0.0652 0.2303
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0444 0.2962
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0039 0.0132 0.0146
Echinococcus granulosus tubulin alpha chain 0.0253 0.1276 0.296
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0444 0.2962
Brugia malayi Tubulin alpha chain 0.0059 0.024 0.0321
Leishmania major epsilon tubulin, putative 0.0136 0.0652 0.2303
Brugia malayi Tubulin beta chain 0.0059 0.024 0.0321
Trichomonas vaginalis tubulin beta chain, putative 0.0253 0.1276 0.8909
Brugia malayi Tubulin gamma chain 0.0136 0.0652 0.089
Schistosoma mansoni tubulin subunit beta 0.0136 0.0652 0.1511
Trichomonas vaginalis tubulin beta chain, putative 0.0253 0.1276 0.8909
Echinococcus granulosus GPCR family 2 0.0016 0.0007 0.0017
Leishmania major beta tubulin 0.0136 0.0652 0.2303
Trichomonas vaginalis tubulin beta chain, putative 0.0253 0.1276 0.8909
Schistosoma mansoni cpg binding protein 0.0061 0.0249 0.0578
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0054 0.0198
Leishmania major alpha tubulin 0.0253 0.1276 0.4678
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.009 0.0167
Entamoeba histolytica hypothetical protein 0.0025 0.0059 0.0236
Echinococcus granulosus short transient receptor potential channel 6 0.0069 0.0294 0.0683
Schistosoma mansoni alpha tubulin 0.0253 0.1276 0.296
Schistosoma mansoni hypothetical protein 0.0337 0.1725 0.4001
Leishmania major beta tubulin 0.0136 0.0652 0.2303
Echinococcus multilocularis beta tubulin 0.0136 0.0652 0.0719
Schistosoma mansoni tubulin subunit beta 0.0136 0.0652 0.1511
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0121 0.0281
Brugia malayi ShTK domain containing protein 0.0188 0.0927 0.127
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0097 0.0444 0.1512
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.0681 0.1579
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0031 0.0071
Schistosoma mansoni hypothetical protein 0.0016 0.0007 0.0017
Leishmania major alpha tubulin 0.0253 0.1276 0.4678
Schistosoma mansoni tubulin subunit alpha 0.0253 0.1276 0.296
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0103 0.0473 0.1097
Onchocerca volvulus Serine\/threonine kinase homolog 0.0097 0.0444 0.0392
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0188 0.0927 0.127
Trypanosoma brucei alpha tubulin 0.0253 0.1276 0.4678
Schistosoma mansoni regulator of G protein signaling 0.002 0.0029 0.0067
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0515 0.2676 1
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0029 0.0032
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0031 0.0071
Trichomonas vaginalis tubulin, putative 0.0059 0.024 0.1504
Plasmodium falciparum tubulin gamma chain 0.0136 0.0652 0.2376
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0007 0.0017
Echinococcus multilocularis peroxisome assembly protein 26 0.0253 0.1276 0.1408
Plasmodium falciparum tubulin epsilon chain, putative 0.0136 0.0652 0.2376
Echinococcus granulosus axis inhibition protein axin 0.002 0.0029 0.0067
Echinococcus granulosus snurportin 1 0.0332 0.1702 0.3947
Schistosoma mansoni tubulin subunit epsilon 0.0136 0.0652 0.1511
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0029 0.0067
Trichomonas vaginalis tubulin alpha chain, putative 0.0136 0.0652 0.4447
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0129
Brugia malayi tubulin alpha chain - mouse 0.0253 0.1276 0.1753
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0861 0.594
Schistosoma mansoni hypothetical protein 0.0034 0.0104 0.0242
Plasmodium vivax telomerase reverse transcriptase, putative 0.0515 0.2676 1
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0029 0.0067
Echinococcus multilocularis protein patched 0.0043 0.0156 0.0172
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0267 0.1352 0.1857
Echinococcus granulosus Niemann Pick C1 protein 0.0101 0.0465 0.1077
Echinococcus granulosus tubulin epsilon chain 0.0136 0.0652 0.1511
Schistosoma mansoni axis inhibition protein axin 0.002 0.0029 0.0067
Echinococcus granulosus Tubulin alpha 1 chain 0.0253 0.1276 0.296
Loa Loa (eye worm) alpha-tubulin 0.0253 0.1276 0.749
Trichomonas vaginalis tubulin epsilon chain, putative 0.0253 0.1276 0.8909
Trichomonas vaginalis tubulin gamma chain, putative 0.0136 0.0652 0.4447
Echinococcus granulosus tubulin subunit beta 0.0136 0.0652 0.1511
Schistosoma mansoni alpha tubulin 0.0253 0.1276 0.296
Brugia malayi Tubulin alpha chain 0.0253 0.1276 0.1753
Loa Loa (eye worm) hypothetical protein 0.0034 0.0104 0.0574
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0029 0.0067
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0861 0.594
Loa Loa (eye worm) tubulin beta-4 chain 0.0136 0.0652 0.3803
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0029 0.0032
Echinococcus granulosus geminin 0.0337 0.1725 0.4001
Trichomonas vaginalis tubulin gamma chain, putative 0.0059 0.024 0.1504
Plasmodium vivax tubulin alpha chain, putative 0.0253 0.1276 0.4729
Loa Loa (eye worm) ShTK domain-containing protein 0.0188 0.0927 0.5427
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0444 0.2962
Trichomonas vaginalis tubulin epsilon chain, putative 0.0136 0.0652 0.4447
Toxoplasma gondii alpha tubulin TUBA1 0.0253 0.1276 0.4678
Leishmania major beta tubulin 0.0136 0.0652 0.2303
Schistosoma mansoni transient receptor potential channel 0.0069 0.0294 0.0683
Echinococcus multilocularis hypothetical protein 0.0253 0.1276 0.1408
Leishmania major importin beta-1 subunit, putative 0.0025 0.0059 0.0047
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.02 0.0586
Onchocerca volvulus 0.0188 0.0927 0.0878
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0029 0.003
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0029 0.0067
Schistosoma mansoni alpha tubulin 0.0253 0.1276 0.296
Leishmania major alpha tubulin 0.0253 0.1276 0.4678
Loa Loa (eye worm) tubulin beta chain 0.0136 0.0652 0.3803
Trichomonas vaginalis tubulin beta chain, putative 0.0253 0.1276 0.8909
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0515 0.2676 1
Brugia malayi hypothetical protein 0.0033 0.0102 0.0131
Echinococcus multilocularis tubulin alpha 1C chain 0.0253 0.1276 0.1408
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0136 0.0652 0.0719
Echinococcus multilocularis tubulin alpha 0.0136 0.0652 0.0719
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0007 0.0008
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0267 0.1352 0.7935
Brugia malayi RNA, U transporter 1 0.0089 0.0397 0.0539
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0275
Echinococcus multilocularis Niemann Pick C1 protein 0.0145 0.0697 0.0769
Loa Loa (eye worm) hypothetical protein 0.0035 0.0113 0.0626
Echinococcus granulosus axis inhibition protein axin 0.002 0.0029 0.0067
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0142 0.0681 0.3975
Trypanosoma cruzi beta tubulin, putative 0.0136 0.0652 0.2303
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0054 0.1707
Schistosoma mansoni tubulin subunit alpha 0.0253 0.1276 0.296
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0077 0.0335 0.2189
Trichomonas vaginalis tubulin alpha chain, putative 0.0077 0.0335 0.2189
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0029 0.003
Loa Loa (eye worm) tubulin alpha-2 chain 0.0253 0.1276 0.749
Trichomonas vaginalis tubulin, putative 0.0077 0.0335 0.2189
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0029 0.0067
Echinococcus multilocularis dnaJ subfamily B 0.082 0.4311 0.4756
Echinococcus granulosus TRP transient receptor potential channel 0.0039 0.0132 0.0306
Brugia malayi Common central domain of tyrosinase family protein 0.0188 0.0927 0.127
Schistosoma mansoni tubulin subunit beta 0.0136 0.0652 0.1511
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0332 0.1702 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0059 0.0211
Onchocerca volvulus 0.0077 0.0335 0.0283
Toxoplasma gondii alpha-tubulin I, putative 0.0253 0.1276 0.4678
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0122 0.0577 0.1338
Trypanosoma brucei epsilon tubulin 0.0136 0.0652 0.2303
Echinococcus granulosus Tubulin alpha 1 chain 0.0253 0.1276 0.296
Leishmania major beta tubulin 0.0136 0.0652 0.2303
Loa Loa (eye worm) tubulin alpha 2 0.0194 0.096 0.5624
Echinococcus multilocularis expressed protein 0.0384 0.1979 0.2184
Schistosoma mansoni glutaminase 0.0282 0.1429 0.3315
Entamoeba histolytica tubulin family protein 0.0136 0.0652 0.4991
Plasmodium falciparum importin beta, putative 0.0031 0.009 0.0261
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.1352 0.9448
Echinococcus multilocularis tubulin alpha chain 0.0253 0.1276 0.1408
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0121 0.0281
Trichomonas vaginalis tubulin beta chain, putative 0.0253 0.1276 0.8909
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0059 0.0047
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0181 0.1085
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0097 0.0444 0.1029
Echinococcus multilocularis tubulin alpha chain 0.0253 0.1276 0.1408
Echinococcus granulosus beta tubulin 0.0136 0.0652 0.1511
Echinococcus granulosus peroxisome assembly protein 26 0.0253 0.1276 0.296
Echinococcus granulosus Tubulin beta 2C chain 0.0136 0.0652 0.1511
Echinococcus multilocularis tubulin alpha chain 0.0253 0.1276 0.1408
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0059 0.024 0.5
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0048 0.011
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0054 0.0029
Trichomonas vaginalis tubulin gamma chain, putative 0.0136 0.0652 0.4447
Echinococcus multilocularis tubulin delta chain 0.0059 0.024 0.0264
Trypanosoma cruzi tubulin delta chain 0.0059 0.024 0.0736
Brugia malayi hypothetical protein 0.002 0.0029 0.003
Echinococcus granulosus Niemann Pick C1 protein 0.0145 0.0697 0.1616
Echinococcus granulosus tubulin gamma 1 chain 0.0136 0.0652 0.1511
Loa Loa (eye worm) hypothetical protein 0.0188 0.0927 0.5427
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.02 0.0675
Loa Loa (eye worm) glutaminase 0.0282 0.1429 0.8391
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0194 0.096 0.5624
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0054 0.0198
Echinococcus granulosus Tubulin beta 2C chain 0.0136 0.0652 0.1511
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0156 0.0876
Schistosoma mansoni tubulin subunit beta 0.0136 0.0652 0.1511
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.1352 0.9448
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.02 0.0675
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0029 0.0129
Leishmania major beta tubulin 0.0136 0.0652 0.2303
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0031 0.0032
Echinococcus granulosus short transient receptor potential channel 6 0.0069 0.0294 0.0683
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0188 0.0927 0.127
Echinococcus granulosus alpha tubulin 0.0253 0.1276 0.296
Echinococcus multilocularis tubulin alpha 1C chain 0.0253 0.1276 0.1408
Schistosoma mansoni hypothetical protein 0.0042 0.0147 0.0342
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0156 0.0361
Loa Loa (eye worm) BEN-1 protein 0.0136 0.0652 0.3803
Trypanosoma brucei zeta tubulin 0.0059 0.024 0.0736
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.0444 0.1512
Leishmania major alpha tubulin 0.0253 0.1276 0.4678
Loa Loa (eye worm) hypothetical protein 0.0105 0.0484 0.2815
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0054 0.0064
Leishmania major beta tubulin 0.0136 0.0652 0.2303
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0444 0.2962
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0019 0.0068
Schistosoma mansoni regulator of G protein signaling 0.002 0.0029 0.0067
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0274 0.0635
Echinococcus granulosus dnaJ subfamily B 0.082 0.4311 1
Mycobacterium leprae cell division protein FtsZ 0.0059 0.024 1
Entamoeba histolytica tubulin alpha-1 chain 0.0253 0.1276 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0188 0.025
Plasmodium vivax tubulin gamma chain, putative 0.0136 0.0652 0.2376
Loa Loa (eye worm) RGS-3 protein 0.002 0.0029 0.0129
Trichomonas vaginalis tubulin beta chain, putative 0.0077 0.0335 0.2189
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0129
Brugia malayi CXXC zinc finger family protein 0.0058 0.0232 0.031
Schistosoma mansoni cpg binding protein 0.0058 0.0232 0.0537
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0861 0.594
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0018 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0156 0.0904
Trichomonas vaginalis tubulin, putative 0.0136 0.0652 0.4447
Leishmania major alpha tubulin 0.0253 0.1276 0.4678
Brugia malayi Tubulin alpha-2 chain 0.0253 0.1276 0.1753
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0181 0.1085
Brugia malayi Cell division protein ftsZ 0.0059 0.024 0.0321
Brugia malayi glutaminase DH11.1 0.0282 0.1429 0.1964
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0861 0.594
Trypanosoma brucei beta tubulin 0.0136 0.0652 0.2303
Plasmodium falciparum tubulin delta chain, putative 0.0059 0.024 0.0824
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.009 0.0167
Trypanosoma brucei tubulin delta chain 0.0059 0.024 0.0736
Schistosoma mansoni kinase 0.0049 0.0188 0.0436
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.02 0.0586
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0444 0.2962
Giardia lamblia Gamma tubulin 0.0136 0.0652 0.2303
Schistosoma mansoni hypothetical protein 0.0037 0.0121 0.0281
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0029 0.0032
Entamoeba histolytica hypothetical protein 0.0037 0.0121 0.0739
Echinococcus multilocularis GPCR, family 2 0.0016 0.0007 0.0008
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0232 0.1324
Giardia lamblia Alpha-tubulin 0.0253 0.1276 0.4678
Leishmania major alpha tubulin 0.0253 0.1276 0.4678
Plasmodium falciparum telomerase reverse transcriptase 0.0515 0.2676 1
Trypanosoma cruzi tubulin delta chain 0.0059 0.024 0.0736
Leishmania major alpha tubulin 0.0253 0.1276 0.4678
Brugia malayi Niemann-Pick C1 protein precursor 0.0101 0.0465 0.0632
Entamoeba histolytica Ran family GTPase 0.0023 0.0046 0.0136
Leishmania major beta tubulin 0.0136 0.0652 0.2303

Activities

Activity type Activity value Assay description Source Reference
Ki (functional) = 4.3 nM Antagonist activity at human CB1 receptor expressed in CHO-K1 cells assessed as inhibition of CP-55940-induced [35S]GTPgammaS binding incubated for 10 mins prior to CP-55940-challenge measured after 1 hr by beta counting ChEMBL. 24900484
Ki (binding) = 4.5 nM Displacement of [3H]SR141716A form human CB1 receptor expressed in HEK293 cells after 60 mins by beta counting ChEMBL. 24900484
Ki (binding) = 8700 nM Displacement of [3H]CP-55940 from human CB2 receptor expressed in CHO-K1 cells after 60 mins by beta counting ChEMBL. 24900484

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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