Detailed information for compound 1658671

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 201.307 | Formula: C14H19N
  • H donors: 0 H acceptors: 0 LogP: 2.64 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC=C=CCN([C@H](c1ccccc1)C)C
  • InChi: 1S/C14H19N/c1-4-5-9-12-15(3)13(2)14-10-7-6-8-11-14/h4,6-11,13H,12H2,1-3H3/t5?,13-/m0/s1
  • InChiKey: GZAVCCSXCPNMJG-BZQJZJKOSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0192 0.0685
Brugia malayi Papain family cysteine protease containing protein 0.0155 0.0515 0.1854
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.072 0.262 0.9437
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0012 0.0044
Schistosoma mansoni cathepsin F (C01 family) 0.0762 0.2776 1
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0053 0.0136 0.0132
Echinococcus granulosus metabotropic glutamate receptor 5 0.0053 0.0136 0.0476
Brugia malayi cathepsin F-like cysteine proteinase 0.0246 0.0855 0.3078
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0017 0.0837
Entamoeba histolytica cysteine protease, putative 0.0401 0.1431 0.5126
Entamoeba histolytica cysteine proteinase, putative 0.0762 0.2776 1
Onchocerca volvulus 0.0155 0.0515 0.1843
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0155 0.0515 0.1822
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0028 0.0042 0.0151
Schistosoma mansoni cathepsin s 0.0246 0.0855 0.3074
Loa Loa (eye worm) hypothetical protein 0.0155 0.0515 0.1854
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0068 0.0753
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0246 0.0855 0.3078
Schistosoma mansoni intermediate filament proteins 0.0031 0.0054 0.0189
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0022 0.0021 0.0062
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0068 0.0206
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0155 0.0515 0.1822
Schistosoma mansoni lamin 0.0031 0.0054 0.0189
Onchocerca volvulus 0.0031 0.0054 0.0181
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0013
Entamoeba histolytica hypothetical protein 0.0155 0.0515 0.1803
Loa Loa (eye worm) RNA binding protein 0.0068 0.0192 0.069
Echinococcus multilocularis cpg binding protein 0.0126 0.0408 0.0405
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0017 0.0023
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0762 0.2776 1
Brugia malayi Latrophilin receptor protein 2 0.0151 0.0501 0.1804
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0022 0.0021 0.0069
Loa Loa (eye worm) hypothetical protein 0.0031 0.0052 0.0187
Loa Loa (eye worm) thioredoxin reductase 0.0056 0.0148 0.0534
Echinococcus granulosus cathepsin b 0.072 0.262 0.9436
Brugia malayi Cathepsin L-like precursor 0.0762 0.2776 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0012 0.0044
Trypanosoma brucei trypanothione reductase 0.0056 0.0148 0.0497
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0278 0.0274
Brugia malayi Cathepsin L-like precursor 0.0762 0.2776 1
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0022 0.0021 0.0037
Leishmania major trypanothione reductase 0.0056 0.0148 0.0497
Brugia malayi cathepsin L precursor 0.0155 0.0515 0.1854
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0163 0.016
Loa Loa (eye worm) CXXC zinc finger family protein 0.0119 0.0383 0.1378
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0052 0.0131 0.0465
Entamoeba histolytica cysteine proteinase, putative 0.0401 0.1431 0.5126
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0012 0.0031
Giardia lamblia Cathepsin L precursor 0.0155 0.0515 0.4363
Mycobacterium tuberculosis Probable reductase 0.0129 0.0418 0.5375
Echinococcus granulosus cysteine protease 0.0401 0.1431 0.515
Echinococcus granulosus tar DNA binding protein 0.0068 0.0192 0.0678
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0022 0.0021 0.0017
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.002 0.0011 0.5
Schistosoma mansoni thyroid hormone receptor 0.002 0.0012 0.0038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0762 0.2776 1
Plasmodium falciparum thioredoxin reductase 0.0056 0.0148 0.0497
Echinococcus multilocularis sterol O acyltransferase 1 0.0228 0.0788 0.0785
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0012 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0039 0.0101
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0155 0.0515 0.1822
Loa Loa (eye worm) hypothetical protein 0.0516 0.1859 0.6698
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0017 0.0023
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0068 0.0206
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.033 0.1166 0.4177
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.0192 0.069
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0039 0.0101
Toxoplasma gondii isocitrate dehydrogenase 0.0052 0.0131 0.0434
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0068 0.0206
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0052 0.0131 0.0127
Entamoeba histolytica cysteine protease, putative 0.0401 0.1431 0.5126
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0018 0.0004 0.0013
Mycobacterium tuberculosis Probable oxidoreductase 0.0143 0.0471 0.6082
Leishmania major cysteine peptidase A (CPA) 0.0762 0.2776 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0762 0.2776 1
Brugia malayi Cathepsin L-like precursor 0.0516 0.1859 0.6698
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.033 0.1166 0.4196
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0087 0.0277
Toxoplasma gondii cathepsin CPL 0.0762 0.2776 1
Brugia malayi Cathepsin L-like precursor 0.0762 0.2776 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0044
Plasmodium falciparum serine repeat antigen 2 0.0155 0.0515 0.1822
Mycobacterium tuberculosis Conserved protein 0.0035 0.0068 0.0753
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0017 0.0023
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0155 0.0515 0.1849
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0022 0.0021 0.0062
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0762 0.2776 1
Entamoeba histolytica cysteine protease, putative 0.0155 0.0515 0.1803
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0052 0.0131 0.0434
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.003 0.0048 0.0045
Entamoeba histolytica cysteine protease, putative 0.0401 0.1431 0.5126
Trypanosoma cruzi cysteine proteinase, putative 0.0401 0.1431 0.5138
Loa Loa (eye worm) isocitrate dehydrogenase 0.0052 0.0131 0.0471
Plasmodium vivax serine-repeat antigen (SERA) 0.0155 0.0515 0.1822
Onchocerca volvulus 0.0035 0.0068 0.0231
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0155 0.0515 0.1822
Brugia malayi Cathepsin L-like precursor 0.0762 0.2776 1
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0039 0.0101
Echinococcus granulosus cathepsin l1 0.0762 0.2776 1
Giardia lamblia Cathepsin L-like protease 0.0155 0.0515 0.4363
Echinococcus granulosus cathepsin l1 0.0516 0.1859 0.6693
Loa Loa (eye worm) hypothetical protein 0.0228 0.0788 0.284
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.0087 0.5021
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0012 0.0031
Onchocerca volvulus 0.0762 0.2776 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0052 0.0131 0.0434
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0155 0.0515 0.1803
Echinococcus multilocularis dnaJ subfamily B 0.0408 0.1457 0.1454
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0039 0.0101
Loa Loa (eye worm) hypothetical protein 0.0029 0.0046 0.0167
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0762 0.2776 1
Plasmodium falciparum serine repeat antigen 4 0.0155 0.0515 0.1822
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0012 0.0008
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0012 0.0044
Giardia lamblia Cathepsin B precursor 0.033 0.1166 1
Loa Loa (eye worm) hypothetical protein 0.0516 0.1859 0.6698
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0017 0.0085
Entamoeba histolytica cysteine protease, putative 0.0762 0.2776 1
Giardia lamblia Cysteine protease 0.0155 0.0515 0.4363
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0087 0.0277
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0155 0.0515 0.1849
Leishmania major cathepsin L-like protease 0.0762 0.2776 1
Echinococcus granulosus o acyltransferase membrane bound domain 0.0022 0.0021 0.0062
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0012 0.0038
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0012 0.0044
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0246 0.0855 0.3078
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0762 0.2776 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0155 0.0515 0.1849
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0021 0.0037
Brugia malayi Cathepsin L-like precursor 0.0516 0.1859 0.6698
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0068 0.0753
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0155 0.0515 0.1822
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0143 0.0471 0.6082
Echinococcus multilocularis tar DNA binding protein 0.0068 0.0192 0.0188
Loa Loa (eye worm) hypothetical protein 0.0035 0.0068 0.0244
Schistosoma mansoni hypothetical protein 0.0022 0.0021 0.0069
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0036 0.0072 0.0098
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0278 0.0995
Echinococcus multilocularis isocitrate dehydrogenase 0.0052 0.0131 0.0127
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0762 0.2776 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0762 0.2776 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0012 0.0031
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0012 0.0044
Brugia malayi Cathepsin L-like precursor 0.0762 0.2776 1
Schistosoma mansoni cathepsin F (C01 family) 0.0762 0.2776 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0155 0.0515 0.1822
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0087 0.0277
Plasmodium vivax glutathione reductase, putative 0.0056 0.0148 0.0497
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0022 0.0021 0.0014
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0068 0.0753
Echinococcus granulosus sterol O acyltransferase 1 0.0228 0.0788 0.283
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0762 0.2776 1
Brugia malayi cathepsin L-like precursor 0.0516 0.1859 0.6698
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0044
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0163 0.0583
Trypanosoma cruzi cysteine peptidase, putative 0.0762 0.2776 1
Entamoeba histolytica cysteine protease, putative 0.0155 0.0515 0.1803
Toxoplasma gondii exonuclease III APE 0.0021 0.0017 0.0023
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0056 0.0148 0.1816
Echinococcus granulosus neuropeptide receptor A26 0.0498 0.1791 0.6448
Loa Loa (eye worm) hypothetical protein 0.0246 0.0855 0.3078
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0401 0.1431 0.5138
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0012 0.0044
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0163 1
Echinococcus multilocularis cathepsin L 0.0155 0.0515 0.0511
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0017 0.0013
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0044
Trypanosoma cruzi cysteine proteinase, putative 0.0401 0.1431 0.5138
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0155 0.0515 0.1849
Toxoplasma gondii cathepsin B 0.033 0.1166 0.4177
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0052 0.0131 0.0434
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0762 0.2776 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0226 0.0781 0.2784
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0762 0.2776 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0762 0.2776 1
Entamoeba histolytica cysteine proteinase, putative 0.0401 0.1431 0.5126
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0039 0.0101
Leishmania major hypothetical protein, conserved 0.0029 0.0046 0.0129
Schistosoma mansoni zinc finger protein 0.0022 0.0021 0.0069
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0012 0.0044
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0017 0.0023
Schistosoma mansoni hypothetical protein 0.0741 0.2698 0.972
Schistosoma mansoni hypothetical protein 0.0151 0.0501 0.1799
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0022 0.0021 0.0037
Trichomonas vaginalis helicase, putative 0.0027 0.0039 0.0101
Giardia lamblia Cathepsin L precursor 0.0155 0.0515 0.4363
Loa Loa (eye worm) hypothetical protein 0.0155 0.0515 0.1854
Loa Loa (eye worm) MBOAT family protein 0.0022 0.0021 0.0075
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0762 0.2776 1
Loa Loa (eye worm) hypothetical protein 0.072 0.262 0.9437
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0087 0.0277
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0087 0.0277
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0036 0.0072 0.0805
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0012 0.0044
Giardia lamblia Cathepsin L precursor 0.0155 0.0515 0.4363
Echinococcus multilocularis cathepsin L cysteine protease 0.0762 0.2776 0.2773
Echinococcus granulosus lamin dm0 0.0031 0.0054 0.0181
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0022 0.0021 0.0062
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0155 0.0515 0.1822
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0401 0.1431 0.5138
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0762 0.2776 1
Brugia malayi MBOAT family protein 0.0022 0.0021 0.0075
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.0011 0.0038
Schistosoma mansoni lamin 0.0031 0.0054 0.0189
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0021 0.0037
Echinococcus multilocularis musashi 0.0031 0.0054 0.005
Entamoeba histolytica cysteine proteinase, putative 0.0401 0.1431 0.5126
Schistosoma mansoni hypothetical protein 0.0408 0.1457 0.5245
Echinococcus granulosus cathepsin b 0.072 0.262 0.9436
Brugia malayi Papain family cysteine protease containing protein 0.0155 0.0515 0.1854
Loa Loa (eye worm) hypothetical protein 0.0155 0.0515 0.1854
Plasmodium vivax vivapain-2 0.0762 0.2776 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0039 0.0101
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0278 0.1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.003 0.0048 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0155 0.0515 0.1822
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0046 0.0129
Brugia malayi Papain family cysteine protease containing protein 0.0762 0.2776 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0068 0.0244
Plasmodium vivax vivapain-1 0.0401 0.1431 0.5138
Loa Loa (eye worm) hypothetical protein 0.0031 0.0054 0.0194
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0192 0.0685
Onchocerca volvulus 0.0762 0.2776 1
Echinococcus multilocularis neuropeptide receptor A26 0.0498 0.1791 0.1788
Onchocerca volvulus 0.0762 0.2776 1
Leishmania major hypothetical protein, conserved 0.0035 0.0068 0.0206
Loa Loa (eye worm) hypothetical protein 0.0175 0.0588 0.212
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0155 0.0515 0.1822
Trypanosoma cruzi cysteine peptidase, putative 0.0762 0.2776 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0056 0.0148 0.0145
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0762 0.2776 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0052 0.0131 0.0127
Echinococcus granulosus lamin 0.0031 0.0054 0.0181
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0155 0.0515 0.1849
Echinococcus multilocularis geminin 0.0741 0.2698 0.2695
Trypanosoma cruzi cysteine protease, putative 0.0401 0.1431 0.5138
Plasmodium vivax vivapain-2 0.0762 0.2776 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0052 0.0131 0.0434
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0762 0.2776 0.2773
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0762 0.2776 1
Brugia malayi cathepsin B-like cysteine proteinase 0.072 0.262 0.9437
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.0768 1
Mycobacterium tuberculosis Conserved protein 0.0035 0.0068 0.0753
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0762 0.2776 1
Onchocerca volvulus 0.0031 0.0054 0.0181
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0022 0.0021 0.0069
Leishmania major cathepsin L-like protease 0.0762 0.2776 1
Onchocerca volvulus 0.0762 0.2776 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0762 0.2776 1
Onchocerca volvulus 0.0175 0.0588 0.211
Plasmodium falciparum serine repeat antigen 6 0.0155 0.0515 0.1822
Loa Loa (eye worm) hhat protein 0.0022 0.0021 0.0075
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0762 0.2776 1
Giardia lamblia Cathepsin L-like protease 0.0155 0.0515 0.4363
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0012 0.0008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0155 0.0515 0.1822
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0155 0.0515 0.1822
Echinococcus granulosus dnaJ subfamily B 0.0408 0.1457 0.5242
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0012 0.0038
Brugia malayi beta-lactamase family protein 0.0035 0.0068 0.0244
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0087 0.0277
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0044
Onchocerca volvulus 0.002 0.0012 0.0031
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0163 0.0576
Onchocerca volvulus Cathepsin L homolog 0.0762 0.2776 1
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0022 0.0021 0.0062
Schistosoma mansoni metabotropic glutamate receptor 0.0053 0.0136 0.0483
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0068 0.0753
Loa Loa (eye worm) hypothetical protein 0.0246 0.0855 0.3078
Plasmodium vivax vivapain-3 0.0401 0.1431 0.5138
Brugia malayi MBOAT family protein 0.0022 0.0021 0.0075
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0052 0.0131 0.0434
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0762 0.2776 1
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0046 0.0129
Schistosoma mansoni mixed-lineage leukemia protein mll 0.003 0.0048 0.0168
Loa Loa (eye worm) ctsf protein 0.0762 0.2776 1
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0192 0.0685
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0155 0.0515 0.1849
Schistosoma mansoni sterol O-acyltransferase 1 0.0228 0.0788 0.2836
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0012 0.0044
Giardia lamblia Cathepsin B precursor 0.033 0.1166 1
Mycobacterium tuberculosis Conserved protein 0.0035 0.0068 0.0753
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0022 0.0021 0.0017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0762 0.2776 1
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0022 0.0021 0.0017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0762 0.2776 1
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0022 0.0021 0.0014
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0163 0.0552
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0022 0.0021 0.0075
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0068 0.0238
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.0087 0.0254
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0155 0.0515 0.1822
Leishmania major glycerol uptake protein, putative 0.0022 0.0021 0.0037
Loa Loa (eye worm) hypothetical protein 0.0053 0.0136 0.0488
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0478 0.1717 0.6184
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0012 0.0008
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0401 0.1431 0.5154
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0192 0.0685
Loa Loa (eye worm) hypothetical protein 0.0035 0.0068 0.0244
Trypanosoma cruzi cysteine peptidase, putative 0.0401 0.1431 0.5138
Brugia malayi cathepsin Z-like cysteine proteinase 0.0155 0.0515 0.1854
Trypanosoma cruzi glycerol uptake protein, putative 0.0022 0.0021 0.0037
Brugia malayi F/Y-rich N-terminus family protein 0.0036 0.0074 0.0265
Schistosoma mansoni cpg binding protein 0.0126 0.0408 0.1465
Entamoeba histolytica cysteine proteinase, putative 0.0401 0.1431 0.5126
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0012 0.0038
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0151 0.0501 0.1793
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0068 0.3736
Brugia malayi beta-lactamase 0.0035 0.0068 0.0244
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0762 0.2776 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0044
Toxoplasma gondii hypothetical protein 0.0022 0.0021 0.0037
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0068 0.0064
Loa Loa (eye worm) cysteine protease 0.0762 0.2776 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0762 0.2776 1
Schistosoma mansoni cathepsin F (C01 family) 0.0516 0.1859 0.6696
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0012 0.0008
Brugia malayi Cathepsin L-like precursor 0.0246 0.0855 0.3078
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0163 0.0552
Echinococcus multilocularis lamin dm0 0.0031 0.0054 0.005
Trypanosoma cruzi major cysteine proteinase, putative 0.0155 0.0515 0.1822
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0068 0.0231
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.033 0.1166 0.4177
Trypanosoma brucei cysteine peptidase C (CPC) 0.033 0.1166 0.4177
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0762 0.2776 0.2773
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0155 0.0515 0.1822
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0037 0.0075 0.0259
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0155 0.0515 0.1803
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0054 0.0194
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0017 0.0023
Schistosoma mansoni cathepsin S (C01 family) 0.0155 0.0515 0.1849
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0762 0.2776 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0129 0.0418 0.5375
Echinococcus multilocularis cathepsin b 0.072 0.262 0.2617
Trichomonas vaginalis conserved hypothetical protein 0.0155 0.0515 0.1822
Onchocerca volvulus 0.0119 0.0383 0.1367
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0155 0.0515 0.1849
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0052 0.0131 0.0434
Trypanosoma cruzi major cysteine proteinase, putative 0.0155 0.0515 0.1822
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0516 0.1859 0.6685
Leishmania major glycerol uptake protein, putative 0.0022 0.0021 0.0037
Loa Loa (eye worm) fibroinase 0.0762 0.2776 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0012 0.0008
Loa Loa (eye worm) hypothetical protein 0.0206 0.0705 0.254
Giardia lamblia Cathepsin L precursor 0.0155 0.0515 0.4363
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0012 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0012 0.0044
Leishmania major hypothetical protein, conserved 0.0022 0.0021 0.0037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0762 0.2776 1
Entamoeba histolytica cysteine proteinase, putative 0.0762 0.2776 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0046 0.0129
Loa Loa (eye worm) hypothetical protein 0.0246 0.0855 0.3078
Onchocerca volvulus 0.0762 0.2776 1
Brugia malayi hypothetical protein 0.0019 0.0008 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0021 0.0037
Brugia malayi steroid hormone receptor 0.002 0.0012 0.0044
Echinococcus multilocularis microtubule associated protein 2 0.0688 0.25 0.2498
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0039 0.0101
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0012 0.0038
Loa Loa (eye worm) hypothetical protein 0.0155 0.0515 0.1854
Echinococcus multilocularis cathepsin L cysteine protease 0.0762 0.2776 0.2773
Schistosoma mansoni ap endonuclease 0.0021 0.0017 0.0056
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0155 0.0515 0.1822
Trypanosoma cruzi trypanothione reductase, putative 0.0056 0.0148 0.0497
Entamoeba histolytica cysteine protease, putative 0.0155 0.0515 0.1803
Onchocerca volvulus 0.0035 0.0068 0.0231
Toxoplasma gondii preprocathepsin c precursor, putative 0.0155 0.0515 0.1822
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0018 0.0004 0.0013
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0012 0.0031
Toxoplasma gondii cathepsin CPC1 0.0155 0.0515 0.1822
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0155 0.0515 0.1854
Trypanosoma cruzi cruzipain precursor, putative 0.0246 0.0855 0.3052
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0012 0.0031
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0012 0.0044
Brugia malayi glutathione reductase 0.0056 0.0148 0.0534
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0278 0.0988
Plasmodium falciparum serine repeat antigen 8 0.0155 0.0515 0.1822
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.004 0.0087 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0068 0.0206
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0054 0.0194
Trypanosoma cruzi glycerol uptake protein, putative 0.0022 0.0021 0.0037
Loa Loa (eye worm) glutamate receptor 0.0043 0.0097 0.0351
Trypanosoma cruzi cruzipain precursor, putative 0.0762 0.2776 1
Entamoeba histolytica vacuolar protein sorting 26 0.0022 0.0021 0.0014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0012 0.0044
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0012 0.0038
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.003 0.0048 0.0161
Trypanosoma cruzi GUP1, putative 0.0022 0.0021 0.0037
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0143 0.0471 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0052 0.0131 0.0434
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0155 0.0515 0.1822
Brugia malayi Isocitrate dehydrogenase 0.0052 0.0131 0.0471
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0401 0.1431 0.5154
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0022 0.0021 0.0014
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0039 0.0101
Loa Loa (eye worm) latrophilin receptor protein 2 0.0151 0.0501 0.1804
Entamoeba histolytica cysteine protease, putative 0.0155 0.0515 0.1803
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0155 0.0515 0.4363
Echinococcus multilocularis neuropeptide s receptor 0.0498 0.1791 0.1788
Loa Loa (eye worm) inositol-1 0.004 0.0087 0.0314
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0762 0.2776 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0762 0.2776 1
Entamoeba histolytica cysteine proteinase, putative 0.0516 0.1859 0.6677
Echinococcus granulosus o acyltransferase membrane bound domain 0.0022 0.0021 0.0062
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.002 0.0011 0.0007
Echinococcus granulosus cathepsin L cysteine proteinase 0.0762 0.2776 1
Trypanosoma brucei glycerol uptake protein, putative 0.0022 0.0021 0.0037
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0151 0.0501 0.0497
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0762 0.2776 1
Plasmodium falciparum serine repeat antigen 5 0.0155 0.0515 0.1822
Giardia lamblia Cysteine protease 0.0155 0.0515 0.4363
Brugia malayi TAR-binding protein 0.0068 0.0192 0.069
Brugia malayi nuclear hormone receptor 0.002 0.0012 0.0044
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.0192 0.069
Echinococcus granulosus mixed lineage leukemia protein mll 0.003 0.0048 0.0161
Echinococcus granulosus cathepsin L cysteine protease 0.0401 0.1431 0.515
Loa Loa (eye worm) hypothetical protein 0.0151 0.0501 0.1804
Brugia malayi CXXC zinc finger family protein 0.0119 0.0383 0.1378
Plasmodium falciparum glutathione reductase 0.0056 0.0148 0.0497
Leishmania major glycerol uptake protein, putative 0.0022 0.0021 0.0037
Schistosoma mansoni cpg binding protein 0.0126 0.0408 0.1465
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0028 0.0042 0.0151
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0762 0.2776 1
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0012 0.0031
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0022 0.0021 0.0075
Plasmodium falciparum serine repeat antigen 9 0.0155 0.0515 0.1822
Entamoeba histolytica cysteine protease, putative 0.0401 0.1431 0.5126
Plasmodium vivax unspecified product 0.0401 0.1431 0.5138
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0046 0.0129
Entamoeba histolytica cysteine protease, putative 0.0401 0.1431 0.5126
Echinococcus granulosus intermediate filament protein 0.0031 0.0054 0.0181
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.033 0.1166 0.4177
Schistosoma mansoni hypothetical protein 0.0018 0.0004 0.0007
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0068 0.0244
Toxoplasma gondii thioredoxin reductase 0.0056 0.0148 0.0497
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0278 0.0995
Trypanosoma cruzi cysteine peptidase, putative 0.0246 0.0855 0.3052
Giardia lamblia Cathepsin B precursor 0.0155 0.0515 0.4363
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0052 0.0131 0.0127
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0087 0.0302
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0044
Mycobacterium ulcerans beta-lactamase 0.0035 0.0068 0.3736
Schistosoma mansoni cathepsin C 0.0155 0.0515 0.1849
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0012 0.0038
Entamoeba histolytica cysteine protease, putative 0.0401 0.1431 0.5126
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0044
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0478 0.1717 0.6184
Giardia lamblia Encystation-specific protease 0.0155 0.0515 0.4363
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0037 0.0075 0.0072
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0068 0.0753
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0046 0.0129
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0068 0.0206
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0762 0.2776 1
Onchocerca volvulus Cathepsin L homolog 0.0762 0.2776 1
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0155 0.0515 0.1822
Plasmodium falciparum serine repeat antigen 1 0.0155 0.0515 0.1822
Loa Loa (eye worm) beta-lactamase 0.0035 0.0068 0.0244
Giardia lamblia Cathepsin B precursor 0.033 0.1166 1
Entamoeba histolytica cysteine protease, putative 0.0401 0.1431 0.5126
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0017 0.0023
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0516 0.1859 0.6685
Schistosoma mansoni microtubule-associated protein tau 0.0688 0.25 0.9007
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0012 0.0008
Loa Loa (eye worm) hypothetical protein 0.0035 0.0068 0.0244
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0012 0.0044
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0068 0.0753
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0087 0.0277
Brugia malayi cathepsin F-like cysteine proteinase 0.0155 0.0515 0.1854
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0022 0.0021 0.0017
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0022 0.0021 0.0017
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0012 0.0008
Echinococcus multilocularis cathepsin L 0.0401 0.1431 0.1428
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0129 0.0418 0.5375
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0017 0.0049
Schistosoma mansoni inositol monophosphatase 0.004 0.0087 0.0309
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0129 0.0418 0.5375
Echinococcus granulosus o acyltransferase membrane bound domain 0.0022 0.0021 0.0062
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0253 0.0881 0.3171
Brugia malayi Papain family cysteine protease containing protein 0.0155 0.0515 0.1854
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0401 0.1431 0.5138
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0022 0.0021 0.0062
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0155 0.0515 0.1822
Loa Loa (eye worm) glutamate receptor 0.0028 0.0042 0.0151
Trichomonas vaginalis porcupine, putative 0.0022 0.0021 0.0037
Leishmania major cathepsin L-like protease 0.0762 0.2776 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0052 0.0131 0.0458
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0052 0.0131 0.1585
Brugia malayi nuclear receptor NHR-88 0.002 0.0012 0.0044
Onchocerca volvulus 0.0022 0.0021 0.0062
Brugia malayi cathepsin L-like cysteine proteinase 0.0155 0.0515 0.1854
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0762 0.2776 1
Schistosoma mansoni hypothetical protein 0.0741 0.2698 0.972
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0762 0.2776 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0017 0.0062
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0163 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.072 0.262 0.9437
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0017 0.6298
Brugia malayi Hhat protein 0.0022 0.0021 0.0075
Leishmania major cathepsin L-like protease 0.0762 0.2776 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0042 0.0151
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0155 0.0515 0.1849
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0022 0.0021 0.0037
Entamoeba histolytica cysteine protease, putative 0.0401 0.1431 0.5126
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0039 0.0101
Loa Loa (eye worm) hypothetical protein 0.0327 0.1154 0.4157
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0022 0.0021 0.0069
Brugia malayi MBOAT family protein 0.0022 0.0021 0.0075
Plasmodium vivax unspecified product 0.0246 0.0855 0.3052
Trypanosoma cruzi glycerol uptake protein, putative 0.0022 0.0021 0.0037
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0155 0.0515 0.1849
Loa Loa (eye worm) hypothetical protein 0.0155 0.0515 0.1854
Mycobacterium ulcerans hypothetical protein 0.0035 0.0068 0.3736
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0046 0.0129
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0012 0.0044
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0012 0.0008
Entamoeba histolytica cysteine protease, putative 0.0401 0.1431 0.5126
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0012 0.0044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0155 0.0515 0.1822
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0129 0.0418 0.5375
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0012 0.0031
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0012 0.0038
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0039 0.0101
Schistosoma mansoni cpg binding protein 0.0119 0.0383 0.1374
Leishmania major glycerol uptake protein, putative 0.0022 0.0021 0.0037
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0155 0.0515 0.1854
Brugia malayi MBOAT family protein 0.0022 0.0021 0.0075
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0012 0.0031
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0068 0.0206
Trichomonas vaginalis esterase, putative 0.0035 0.0068 0.0206
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0155 0.0515 0.1822
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0151 0.0501 0.1804
Brugia malayi diacylglycerol acyltransferase 0.0022 0.0021 0.0075
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0022 0.0021 0.0037
Brugia malayi Thioredoxin reductase 0.0056 0.0148 0.0534
Trypanosoma cruzi GUP1, putative 0.0022 0.0021 0.0037
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0129 0.0418 0.5375
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0155 0.0515 0.1822
Schistosoma mansoni inositol monophosphatase 0.004 0.0087 0.0309
Trichomonas vaginalis transmembrane protein nessy, putative 0.0022 0.0021 0.0037
Echinococcus granulosus geminin 0.0741 0.2698 0.9719
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0278 0.0995
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0039 0.0101
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0087 0.0084
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0155 0.0515 0.1854
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0068 0.0238
Brugia malayi isocitrate dehydrogenase 0.0052 0.0131 0.0471
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0068 0.3736
Echinococcus multilocularis GPCR, family 2 0.0151 0.0501 0.0497
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0762 0.2776 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0278 0.0274
Giardia lamblia Cathepsin B precursor 0.0155 0.0515 0.4363
Echinococcus granulosus cathepsin L 0.0155 0.0515 0.1843
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0068 0.0206
Treponema pallidum alginate O-acetylation protein (algI) 0.0022 0.0021 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0012 0.0044
Entamoeba histolytica cysteine protease, putative 0.0155 0.0515 0.1803
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0163 0.2016
Brugia malayi RNA binding protein 0.0068 0.0192 0.069
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0087 0.0277
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0012 0.0038
Echinococcus multilocularis cysteine protease 0.0762 0.2776 0.2773
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0012 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0012 0.0044
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0039 0.0101
Loa Loa (eye worm) glutathione reductase 0.0056 0.0148 0.0534
Entamoeba histolytica hypothetical protein 0.0022 0.0021 0.0014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0401 0.1431 0.5138
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0762 0.2776 1
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0155 0.0515 0.1822
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0039 0.0101
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0043 0.0097 0.0345
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0022 0.0021 0.0069
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0022 0.0021 0.0017
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0163 0.0583
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0762 0.2776 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0075
Plasmodium falciparum serine repeat antigen 3 0.0155 0.0515 0.1822
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0022 0.0021 0.0069
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0155 0.0515 0.1822
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0762 0.2776 1
Echinococcus granulosus cpg binding protein 0.0126 0.0408 0.1459
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0155 0.0515 0.1822
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0516 0.1859 0.6685
Entamoeba histolytica hypothetical protein, conserved 0.0022 0.0021 0.0014
Schistosoma mansoni hypothetical protein 0.0151 0.0501 0.1799
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0022 0.0021 0.0069
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0017 0.0062
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0401 0.1431 0.5138
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0192 0.0685
Onchocerca volvulus Cathepsin F homolog 0.0762 0.2776 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0478 0.1717 0.6184
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0762 0.2776 1
Giardia lamblia Cathepsin B precursor 0.0155 0.0515 0.4363
Leishmania major cathepsin L-like protease 0.0762 0.2776 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0056 0.0148 0.0521
Brugia malayi hypothetical protein 0.0029 0.0046 0.0167
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0012 0.0008
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0017 0.0023
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0022 0.0021 0.0017
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0155 0.0515 0.1822
Brugia malayi cathepsin Z-like cysteine proteinase 0.0155 0.0515 0.1854
Brugia malayi MBOAT family protein 0.0022 0.0021 0.0075
Entamoeba histolytica cysteine proteinase 2 0.0401 0.1431 0.5126
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0155 0.0515 0.1822
Loa Loa (eye worm) hhat protein 0.0022 0.0021 0.0075
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0151 0.0501 0.0497
Entamoeba histolytica cysteine protease, putative 0.0401 0.1431 0.5126
Brugia malayi latrophilin 2 splice variant baaae 0.0327 0.1154 0.4157
Plasmodium falciparum serine repeat antigen 7 0.0155 0.0515 0.1822
Loa Loa (eye worm) cathepsin B 0.033 0.1166 0.4199
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0155 0.0515 0.4363
Schistosoma mansoni thyroid hormone receptor 0.002 0.0012 0.0038
Brugia malayi Cathepsin L-like cysteine proteinase 0.0516 0.1859 0.6698
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0012 0.0044
Loa Loa (eye worm) hypothetical protein 0.0035 0.0068 0.0244
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0012 0.0038
Entamoeba histolytica cysteine protease, putative 0.0155 0.0515 0.1803
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0155 0.0515 0.1822
Brugia malayi Receptor family ligand binding region containing protein 0.0028 0.0042 0.0151
Echinococcus granulosus cathepsin L 0.0401 0.1431 0.515
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0068 0.0753
Trypanosoma cruzi cysteine peptidase, putative 0.0762 0.2776 1
Schistosoma mansoni coup transcription factor 0.002 0.0012 0.0038
Giardia lamblia Cathepsin L precursor 0.0155 0.0515 0.4363
Brugia malayi intermediate filament protein 0.0031 0.0054 0.0194
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0155 0.0515 0.4363
Schistosoma mansoni hypothetical protein 0.0151 0.0501 0.1799
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0039 0.0101
Mycobacterium ulcerans lipase LipD 0.0035 0.0068 0.3736
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0155 0.0515 0.1822
Entamoeba histolytica cysteine protease, putative 0.0401 0.1431 0.5126
Entamoeba histolytica cysteine protease, putative 0.0401 0.1431 0.5126
Loa Loa (eye worm) histone methyltransferase 0.0037 0.0075 0.0272
Plasmodium vivax serine-repeat antigen (SERA) 0.0155 0.0515 0.1822
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0762 0.2776 1
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0046 0.0129
Plasmodium falciparum cysteine proteinase falcipain 1 0.0401 0.1431 0.5138
Echinococcus granulosus microtubule associated protein 2 0.0688 0.25 0.9007
Loa Loa (eye worm) TAR-binding protein 0.0068 0.0192 0.069
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0155 0.0515 0.1822
Brugia malayi fibroinase precursor 0.0155 0.0515 0.1854
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.072 0.262 0.9437
Brugia malayi hypothetical protein 0.0175 0.0588 0.212
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0052 0.0131 0.0127
Toxoplasma gondii cathepsin CPC2 0.0155 0.0515 0.1822
Echinococcus multilocularis lamin 0.0031 0.0054 0.005
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0278 0.0988
Schistosoma mansoni nuclear hormone receptor 0.002 0.0012 0.0038
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0075
Echinococcus granulosus neuropeptide s receptor 0.0498 0.1791 0.6448
Brugia malayi beta-lactamase family protein 0.0035 0.0068 0.0244
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0017 0.0056
Loa Loa (eye worm) MBOAT family protein 0.0022 0.0021 0.0075
Brugia malayi Papain family cysteine protease containing protein 0.0401 0.1431 0.5156
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0017 0.0023
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0012 0.0031
Onchocerca volvulus 0.0762 0.2776 1
Giardia lamblia Cathepsin L precursor 0.0155 0.0515 0.4363
Echinococcus multilocularis cysteine protease 0.0762 0.2776 0.2773
Echinococcus granulosus GPCR family 2 0.0151 0.0501 0.1793
Loa Loa (eye worm) hypothetical protein 0.0035 0.0068 0.0244
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0155 0.0515 0.1822
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0017 0.042
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0039 0.0101
Echinococcus granulosus FTZ F1 alpha 0.002 0.0012 0.0031
Brugia malayi Papain family cysteine protease containing protein 0.0401 0.1431 0.5156
Brugia malayi ecdysteroid receptor 0.002 0.0012 0.0044
Toxoplasma gondii isocitrate dehydrogenase 0.0052 0.0131 0.0434
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0762 0.2776 1
Loa Loa (eye worm) hypothetical protein 0.0155 0.0515 0.1854
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0075
Leishmania major cathepsin L-like protease 0.0762 0.2776 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0151 0.0501 0.1793
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0155 0.0515 0.1822
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0022 0.0021 0.0017
Toxoplasma gondii ABC1 family protein 0.0035 0.0068 0.0206
Schistosoma mansoni hypothetical protein 0.0151 0.0501 0.1799
Giardia lamblia Hypothetical protein 0.0155 0.0515 0.4363
Entamoeba histolytica cysteine proteinase 1, putative 0.0401 0.1431 0.5126
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0044
Loa Loa (eye worm) hypothetical protein 0.0035 0.0068 0.0244
Plasmodium vivax thioredoxin reductase, putative 0.0056 0.0148 0.0497
Schistosoma mansoni ap endonuclease 0.0021 0.0017 0.0056
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0401 0.1431 0.5154
Giardia lamblia Cathepsin B precursor 0.0155 0.0515 0.4363
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0012 0.0031
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0155 0.0515 0.4363
Giardia lamblia Cysteine protease 0.0155 0.0515 0.4363
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0155 0.0515 0.1854
Loa Loa (eye worm) MBOAT family protein 0.0022 0.0021 0.0075
Entamoeba histolytica cysteine protease, putative 0.0401 0.1431 0.5126
Leishmania major cathepsin L-like protease 0.0762 0.2776 1
Leishmania major cathepsin L-like protease 0.0762 0.2776 1
Trypanosoma cruzi cysteine peptidase, putative 0.0762 0.2776 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0068 0.0206
Leishmania major glycerol uptake protein, putative 0.0022 0.0021 0.0037
Brugia malayi Inositol-1 0.004 0.0087 0.0314
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.072 0.262 0.9435
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0054 0.0194
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0278 0.1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0012 0.0044
Giardia lamblia Cathepsin B precursor 0.0155 0.0515 0.4363
Loa Loa (eye worm) hypothetical protein 0.0478 0.1717 0.6184
Loa Loa (eye worm) hypothetical protein 0.0516 0.1859 0.6698
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0012 0.0044
Brugia malayi metabotropic glutamate receptor type 2 0.0053 0.0136 0.0488
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0012 0.0044
Schistosoma mansoni cathepsin B (C01 family) 0.0155 0.0515 0.1849
Giardia lamblia Hypothetical protein 0.0155 0.0515 0.4363
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0039 0.0101
Giardia lamblia Cysteine protease 0.0155 0.0515 0.4363
Onchocerca volvulus Cathepsin L homolog 0.0155 0.0515 0.1843
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0129 0.0418 0.8673
Brugia malayi Metabotropic glutamate receptor precursor. 0.0028 0.0042 0.0151
Trichomonas vaginalis conserved hypothetical protein 0.0155 0.0515 0.1822
Onchocerca volvulus 0.0762 0.2776 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0068 0.0206
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0143 0.0471 0.6082
Onchocerca volvulus 0.0035 0.0068 0.0231
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0039 0.0101
Onchocerca volvulus 0.0516 0.1859 0.6693
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0163 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.072 0.262 0.9437
Plasmodium falciparum cysteine proteinase falcipain 3 0.0762 0.2776 1
Brugia malayi Cathepsin L-like precursor 0.0762 0.2776 1
Trypanosoma brucei glycerol uptake protein, putative 0.0022 0.0021 0.0037
Echinococcus multilocularis cathepsin b 0.072 0.262 0.2617
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.002 0.0011 0.0025
Loa Loa (eye worm) hypothetical protein 0.0762 0.2776 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0012 0.0044
Schistosoma mansoni hypothetical protein 0.0327 0.1154 0.4153
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0762 0.2776 1
Plasmodium vivax unspecified product 0.0155 0.0515 0.1822
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.002 0.0011 0.0033

Activities

Activity type Activity value Assay description Source Reference
k2 (binding) = 0.007 min-1 Kinetic parameter for the time dependent inhibition of Bovine liver Monoamine Oxidase B at 25 degrees C (pH= 7.4). ChEMBL. 3397993
k2 (binding) = 0.012 min-1 Kinetic parameter for the time dependent inhibition of Bovine liver Monoamine Oxidase B at 25 degrees C (pH= 7.4). ChEMBL. 3397993
Ki (binding) = 1.1 mM In vitro inhibition of bovine monoamine oxidase B. ChEMBL. 3397993
Ki (binding) = 2.6 mM In vitro inhibition of bovine monoamine oxidase B. ChEMBL. 3397993

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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