Detailed information for compound 1674154

Basic information

Technical information
  • TDR Targets ID: 1674154
  • Name: 1-(4-fluorophenyl)-N-[[1-(4-fluorophenyl)ethy lideneamino]oxymethoxy]ethanimine
  • MW: 318.318 | Formula: C17H16F2N2O2
  • H donors: 0 H acceptors: 0 LogP: 4.45 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: C/C(=N/OCO/N=C(\c1ccc(cc1)F)/C)/c1ccc(cc1)F
  • InChi: 1S/C17H16F2N2O2/c1-12(14-3-7-16(18)8-4-14)20-22-11-23-21-13(2)15-5-9-17(19)10-6-15/h3-10H,11H2,1-2H3/b20-12-,21-13-
  • InChiKey: IESRGEOYCVWPFK-FDYZEBBJSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (Z)-1-(4-fluorophenyl)ethylidene-[[1-(4-fluorophenyl)ethylideneamino]oxymethoxy]amine
  • STK209048
  • BIM-0004878.P001

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens polypyrimidine tract binding protein 1 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major hypothetical protein, conserved Get druggable targets OG5_127719 All targets in OG5_127719
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Plasmodium knowlesi polypyrimidine tract-binding protein, putative Get druggable targets OG5_127719 All targets in OG5_127719
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei Double RNA-binding domain containing protein 4 Get druggable targets OG5_127719 All targets in OG5_127719
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni polypyrimidine tract binding protein Get druggable targets OG5_127719 All targets in OG5_127719
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127719 All targets in OG5_127719
Schistosoma mansoni polypyrimidine tract binding protein Get druggable targets OG5_127719 All targets in OG5_127719
Trypanosoma brucei gambiense RNA-binding protein, putative,DRBD4 Get druggable targets OG5_127719 All targets in OG5_127719
Schistosoma japonicum expressed protein Get druggable targets OG5_127719 All targets in OG5_127719
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127719 All targets in OG5_127719
Plasmodium berghei polypyrimidine tract-binding protein, putative Get druggable targets OG5_127719 All targets in OG5_127719
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi hypothetical protein Get druggable targets OG5_127719 All targets in OG5_127719
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Plasmodium falciparum polypyrimidine tract-binding protein, putative Get druggable targets OG5_127719 All targets in OG5_127719
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii RNA recognition motif-containing protein Get druggable targets OG5_127719 All targets in OG5_127719
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense polypyrimidine tract-binding protein, putative Get druggable targets OG5_127719 All targets in OG5_127719
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani Double RNA binding domain protein 3 Get druggable targets OG5_127719 All targets in OG5_127719
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127719 All targets in OG5_127719
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania donovani polypyrimidine tract-binding protein, putative Get druggable targets OG5_127719 All targets in OG5_127719
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma brucei gambiense RNA-binding protein, putative,DRBD4 Get druggable targets OG5_127719 All targets in OG5_127719
Plasmodium yoelii neural polypyrimidine tract binding protein Get druggable targets OG5_127719 All targets in OG5_127719
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis hypothetical protein, conserved Get druggable targets OG5_127719 All targets in OG5_127719
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma japonicum Polypyrimidine tract-binding protein 1, putative Get druggable targets OG5_127719 All targets in OG5_127719
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma cruzi polypyrimidine tract-binding protein, putative Get druggable targets OG5_127719 All targets in OG5_127719
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis Regulator of differentiation 1 Get druggable targets OG5_127719 All targets in OG5_127719
Plasmodium vivax polypyrimidine tract binding protein, putative Get druggable targets OG5_127719 All targets in OG5_127719
Leishmania mexicana RNA-binding protein, putative Get druggable targets OG5_127719 All targets in OG5_127719
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma mansoni polypyrimidine tract binding protein Get druggable targets OG5_127719 All targets in OG5_127719
Trypanosoma cruzi Double RNA binding domain protein 3 Get druggable targets OG5_127719 All targets in OG5_127719
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Regulator of differentiation 1, putative Get druggable targets OG5_127719 All targets in OG5_127719
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania braziliensis RNA-binding protein, putative Get druggable targets OG5_127719 All targets in OG5_127719
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Neospora caninum GG11844, related Get druggable targets OG5_127719 All targets in OG5_127719
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania major RNA-binding protein, putative Get druggable targets OG5_127719 All targets in OG5_127719
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127719 All targets in OG5_127719
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma brucei Double RNA binding domain protein 3 Get druggable targets OG5_127719 All targets in OG5_127719
Onchocerca volvulus Get druggable targets OG5_127719 All targets in OG5_127719
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma congolense Double RNA binding domain protein 3 Get druggable targets OG5_127719 All targets in OG5_127719
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania infantum RNA-binding protein, putative Get druggable targets OG5_127719 All targets in OG5_127719
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127719 All targets in OG5_127719
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus Regulator of differentiation 1 Get druggable targets OG5_127719 All targets in OG5_127719
Leishmania mexicana hypothetical protein, conserved Get druggable targets OG5_127719 All targets in OG5_127719
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania infantum hypothetical protein, conserved Get druggable targets OG5_127719 All targets in OG5_127719
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis heterogeneous nuclear ribonucleoprotein l polypyrimidine tract binding protein 1 557 aa 517 aa 28.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0179 0.0162
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0502 0.0502
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.2887 0.3691
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0578 0.2288
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.1196 0.5219
Onchocerca volvulus Alhambra homolog 0.0035 0.0578 0.0104
Schistosoma mansoni jumonji/arid domain-containing protein 0.0045 0.0858 0.3616
Loa Loa (eye worm) hypothetical protein 0.0032 0.0485 0.0469
Brugia malayi Bromodomain containing protein 0.0091 0.2174 0.2174
Brugia malayi Pre-SET motif family protein 0.0036 0.0603 0.0603
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0157 0.029
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0578 0.0722
Brugia malayi PHD-finger family protein 0.003 0.0431 0.0431
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0135 0.3462 0.3399
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0502 0.0486
Brugia malayi Muscleblind-like protein 0.018 0.4763 0.4763
Echinococcus multilocularis lamin 0.0033 0.0502 0.0624
Brugia malayi Pre-SET motif family protein 0.0251 0.6808 0.6808
Echinococcus granulosus lamin dm0 0.0033 0.0502 0.0624
Schistosoma mansoni hypothetical protein 0.0035 0.0578 0.2288
Schistosoma mansoni hypothetical protein 0.0025 0.0282 0.0881
Schistosoma mansoni bromodomain containing protein 0.0076 0.1766 0.7923
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0792 0.0997
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.7794 1
Brugia malayi intermediate filament protein 0.0033 0.0502 0.0502
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0066 0.0066
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0603 0.2403
Loa Loa (eye worm) hypothetical protein 0.0185 0.4898 0.4889
Echinococcus multilocularis lamin dm0 0.0033 0.0502 0.0624
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.1242 0.1242
Brugia malayi jmjC domain containing protein 0.0045 0.0858 0.0858
Brugia malayi Bromodomain containing protein 0.0038 0.0661 0.0661
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0814 0.1026
Plasmodium vivax SET domain protein, putative 0.0036 0.0603 1
Echinococcus granulosus muscleblind protein 0.018 0.4763 0.6103
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.1196 0.5219
Echinococcus multilocularis zinc finger protein 0.0024 0.0245 0.0294
Echinococcus granulosus histone lysine methyltransferase setb 0.0057 0.1196 0.1517
Trypanosoma brucei Emopamil binding protein, putative 0.0135 0.3462 0.3399
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.6808 0.6802
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0603 0.2403
Loa Loa (eye worm) hypothetical protein 0.006 0.1303 0.1289
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0157 0.029
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0362 1 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0045 0.0858 0.3616
Trypanosoma cruzi Emopamil binding protein, putative 0.0135 0.3462 0.3399
Leishmania major hypothetical protein, conserved 0.0135 0.3462 0.3399
Onchocerca volvulus 0.0058 0.1242 0.1013
Leishmania major 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0135 0.3462 0.3399
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0578 0.0563
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0603 1
Brugia malayi Bromodomain containing protein 0.0046 0.0897 0.0897
Loa Loa (eye worm) hypothetical protein 0.0033 0.0502 0.0486
Schistosoma mansoni survival motor neuron protein 0.0058 0.1242 0.5438
Schistosoma mansoni hypothetical protein 0.0058 0.1242 0.5438
Onchocerca volvulus 0.0135 0.3462 0.4051
Echinococcus multilocularis musashi 0.0033 0.0502 0.0624
Plasmodium falciparum phd finger protein, putative 0.0035 0.0578 0.5
Loa Loa (eye worm) hypothetical protein 0.0035 0.0578 0.0563
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0976 0.1233
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.2887 0.3691
Loa Loa (eye worm) hypothetical protein 0.0286 0.7794 0.7791
Echinococcus granulosus lamin 0.0033 0.0502 0.0624
Schistosoma mansoni zinc finger protein 0.0024 0.0245 0.0706
Loa Loa (eye worm) hypothetical protein 0.018 0.4763 0.4754
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0564 0.0704
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.7794 1
Trypanosoma cruzi Emopamil binding protein, putative 0.0135 0.3462 0.3399
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0348 0.0426
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0348 0.1196
Echinococcus multilocularis muscleblind protein 0.018 0.4763 0.6103
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0976 0.1233
Loa Loa (eye worm) hypothetical protein 0.0046 0.0899 0.0884
Schistosoma mansoni lamin 0.0033 0.0502 0.1927
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0157 0.0181
Giardia lamblia PHD finger protein 15 0.0035 0.0578 0.5
Loa Loa (eye worm) hypothetical protein 0.0085 0.2025 0.2012
Loa Loa (eye worm) hypothetical protein 0.0052 0.1048 0.1033
Onchocerca volvulus 0.0036 0.0603 0.0137
Echinococcus granulosus lysine specific demethylase 5A 0.0045 0.0858 0.1082
Leishmania major C-8 sterol isomerase-like protein 0.0362 1 1
Echinococcus multilocularis peregrin 0.0038 0.0661 0.0828
Trypanosoma brucei C-8 sterol isomerase, putative 0.0362 1 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0045 0.0858 0.0843
Onchocerca volvulus 0.0286 0.7808 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0578 0.0722
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0282 0.0266
Trichomonas vaginalis set domain proteins, putative 0.0286 0.7808 0.5
Loa Loa (eye worm) hypothetical protein 0.018 0.4763 0.4754
Loa Loa (eye worm) hypothetical protein 0.0049 0.0982 0.0967
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0066 0.005
Brugia malayi jmjC domain containing protein 0.0115 0.2887 0.2887
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0157 0.0181
Echinococcus multilocularis muscleblind protein 1 0.018 0.4763 0.6103
Echinococcus granulosus intermediate filament protein 0.0033 0.0502 0.0624
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.1642 0.2089
Loa Loa (eye worm) hypothetical protein 0.0057 0.1196 0.1182
Brugia malayi hypothetical protein 0.0286 0.7794 0.7794
Schistosoma mansoni lamin 0.0033 0.0502 0.1927
Echinococcus granulosus peregrin 0.0038 0.0661 0.0828
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.1642 0.2089
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0348 0.0426
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0502 0.0486
Schistosoma mansoni jumonji domain containing protein 0.0092 0.2204 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0814 0.1026
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0603 0.0753
Echinococcus granulosus zinc finger protein 0.0024 0.0245 0.0294
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0057 0.1196 0.1517
Brugia malayi PHD-finger family protein 0.0035 0.0578 0.0578
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0135 0.3462 0.3399
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.1659 0.1645
Schistosoma mansoni intermediate filament proteins 0.0033 0.0502 0.1927
Loa Loa (eye worm) hypothetical protein 0.0362 1 1

Activities

Activity type Activity value Assay description Source Reference
Potency (binding) 0.2818 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: High Content Assay for Compounds that inhibit the Assembly of the Perinucleolar Compartment: PC3M Cytotoxicity. (Class of assay: confirmatory) [Related pubchem assays: 2431 (Summary assay), 2417 (Primary screen)] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 21.3313 uM PUBCHEM_BIOASSAY: qHTS for antagonists of the Thyroid Stimulation Hormone Receptor: Hit Validation in Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: High Content Assay for Compounds that inhibit the Assembly of the Perinucleolar Compartment: Confirmation of PNC Inhibition. (Class of assay: confirmatory) [Related pubchem assays: 2431 (Summary assay), 2417 (Primary screen)] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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