TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 366.46 | Formula: C20H26N6O
H donors: 3 H acceptors: 2 LogP: 3.35 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1ccc(cc1)Nc1c(C)c(NC2CCCNC2)nc2n1ncc2
InChi: 1S/C20H26N6O/c1-3-27-17-8-6-15(7-9-17)24-20-14(2)19(23-16-5-4-11-21-13-16)25-18-10-12-22-26(18)20/h6-10,12,16,21,24H,3-5,11,13H2,1-2H3,(H,23,25)
InChiKey: WJOUGMPFYANZMI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	mitogen-activated protein kinase-activated protein kinase 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K04443 mitogen-activated protein kinase-activated protein kinase 2, putative	Get druggable targets OG5_131483	All targets in OG5_131483
Brugia malayi	map kinase activated protein kinase protein 2	Get druggable targets OG5_131483	All targets in OG5_131483
Echinococcus granulosus	MAP kinase activated protein kinase 2	Get druggable targets OG5_131483	All targets in OG5_131483
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_131483	All targets in OG5_131483
Echinococcus multilocularis	MAP kinase activated protein kinase 2	Get druggable targets OG5_131483	All targets in OG5_131483
Loa Loa (eye worm)	camk/mapkapk/mapkapk protein kinase	Get druggable targets OG5_131483	All targets in OG5_131483

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	mitogen-activated protein kinase-activated protein kinase 2	370 aa	303 aa	26.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	N-terminal motif family protein	0.0178	0.3803	0.403
Schistosoma mansoni	neurotransmitter gated ion channel	0.0006	0.0021	0.0017
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0518	0.0549
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0124	0.0131
Brugia malayi	intermediate filament protein	0.0028	0.0506	0.0536
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0039	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0042	0.0044
Brugia malayi	regulator of G-protein signaling egl-10	0.0009	0.0091	0.0096
Onchocerca volvulus		0.0012	0.0164	0.0419
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0075	0.1547	0.1639
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0007	0.0042	0.0044
Echinococcus multilocularis	serine:threonine protein kinase Chk2	0.0047	0.0928	0.0979
Schistosoma mansoni	nAChR subunit	0.0006	0.0021	0.0017
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0012	0.0164	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0036	0.0038
Brugia malayi	hypothetical protein	0.0005	0.0005	0.0005
Schistosoma mansoni	serine/threonine protein kinase	0.0005	0.0016	0.0011
Echinococcus granulosus	son of sevenless 1	0.0006	0.0036	0.0033
Echinococcus granulosus	nAChR subunit	0.0007	0.0042	0.0039
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0053	0.0051
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0124	0.0131
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0007	0.0053	0.0051
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0012	0.0164	0.0169
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0012	0.0164	0.0174
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0039	0.0024
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0124	0.0126
Echinococcus granulosus	Pleckstrin G protein interacting region	0.0009	0.0091	0.0091
Mycobacterium ulcerans	lipase LipD	0.0072	0.148	0.5
Onchocerca volvulus		0.0012	0.0164	0.0419
Mycobacterium ulcerans	esterase/lipase LipP	0.0072	0.148	0.5
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.006	0.1213	0.1281
Onchocerca volvulus		0.0072	0.148	0.3883
Brugia malayi	Smad1	0.0008	0.0082	0.0087
Onchocerca volvulus		0.0028	0.0506	0.1319
Onchocerca volvulus		0.0081	0.167	0.4383
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0039	0.0024
Echinococcus multilocularis	rap guanine nucleotide exchange factor 6	0.0006	0.0036	0.0033
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0039	0.0024
Echinococcus granulosus	Smad4	0.0008	0.0082	0.0082
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0006	0.0039	0.0024
Loa Loa (eye worm)	nuclear hormone receptor	0.0005	0.0005	0.0005
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0124	0.0126
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0124	0.0131
Onchocerca volvulus		0.0009	0.0091	0.0226
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0124	0.0131
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0012	0.0164	0.0169
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0005	0.0018	0.0014
Echinococcus granulosus	GPCR family 2	0.0068	0.1388	0.1466
Brugia malayi	N-terminal motif family protein	0.0006	0.0036	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0042	0.0044
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0124	0.0131
Brugia malayi	ecdysone receptor	0.0005	0.0005	0.0005
Schistosoma mansoni	camp-dependent rap1 guanine-nucleotide exchange factor	0.0006	0.0029	0.0026
Brugia malayi	hypothetical protein	0.0006	0.0021	0.0022
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0124	0.0126
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0215	0.4605	0.4879
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0164	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0021	0.0022
Brugia malayi	Nuclear hormone receptor-like 1	0.0005	0.0018	0.0019
Echinococcus granulosus	mothers against decapentaplegic 5	0.0008	0.0082	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0164	0.0174
Loa Loa (eye worm)	hypothetical protein	0.001	0.0124	0.0131
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0124	0.0131
Echinococcus multilocularis	segment polarity protein dishevelled	0.0009	0.0091	0.0091
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0039	0.0024
Brugia malayi	hypothetical protein	0.0006	0.0021	0.0022
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0012	0.0164	0.0174
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0012	0.0164	0.0174
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0012	0.0164	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0072	0.148	0.1568
Loa Loa (eye worm)	DIX domain-containing protein	0.0009	0.0091	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0021	0.0022
Echinococcus multilocularis	MAP kinase activated protein kinase 2	0.0435	0.9438	1
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0012	0.0164	0.0174
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0124	0.0131
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0224	0.0237
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0012	0.0164	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0081	0.167	0.1769
Brugia malayi	RasGEF domain containing protein	0.0006	0.0036	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0005	0.0005
Brugia malayi	Egg laying defective protein 4	0.0005	0.0016	0.0016
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0005	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0042	0.0044
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0082	0.0082
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0124	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0021	0.0022
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.009	0.0091
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0124	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0506	0.0536
Loa Loa (eye worm)	MH2 domain-containing protein	0.0123	0.2587	0.2742
Schistosoma mansoni	nAChR subunit	0.0012	0.0164	0.0169
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0012	0.0164	0.0174
Schistosoma mansoni	neurotransmitter gated ion channel	0.0006	0.0021	0.0017
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0124	0.0131
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0124	0.0126
Brugia malayi	nuclear hormone receptor	0.001	0.0124	0.0131
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0012	0.0164	0.0169
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0005	0.0016	0.0011
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0007	0.0042	0.0044
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0039	0.0024
Schistosoma mansoni	hypothetical protein	0.0167	0.3564	0.3773
Onchocerca volvulus		0.0072	0.148	0.3883
Loa Loa (eye worm)	acetylcholine receptor protein	0.0006	0.0021	0.0022
Brugia malayi	nuclear receptor NHR-88	0.001	0.0124	0.0131
Echinococcus multilocularis	glycine receptor subunit beta	0.0012	0.0164	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0091	0.0096
Schistosoma mansoni	serine/threonine protein kinase	0.0435	0.9438	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0495	0.0524
Echinococcus multilocularis	son of sevenless 1	0.0006	0.0036	0.0033
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0088	0.0093
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0006	0.0021	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0005	0.0005
Schistosoma mansoni	z-protein (S1r protein)	0.0009	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.001	0.0124	0.0131
Echinococcus granulosus	lamin dm0	0.0028	0.0506	0.0531
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0007	0.0053	0.0051
Schistosoma mansoni	hypothetical protein	0.0068	0.1388	0.1466
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0005	0.0005
Loa Loa (eye worm)	AGC/PKG protein kinase	0.0005	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0164	0.0174
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0072	0.148	0.1568
Brugia malayi	MH2 domain containing protein	0.0008	0.0082	0.0087
Mycobacterium ulcerans	beta-lactamase	0.0072	0.148	0.5
Trichomonas vaginalis	D-aminoacylase, putative	0.0072	0.148	1
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0124	0.0126
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0124	0.0126
Schistosoma mansoni	nAChR subunit	0.0012	0.0164	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0005	0.0005
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0039	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0081	0.167	0.1769
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0005	0.0005
Echinococcus granulosus	geminin	0.0167	0.3564	0.3773
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0005	0.0005	0.0005
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0124	0.0126
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0006	0.0021	0.0022
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0039	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0091	0.0096
Brugia malayi	Nuclear hormone receptor-like 1	0.0005	0.0018	0.0019
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0039	0.0024
Echinococcus multilocularis	ras GTP exchange factor	0.0006	0.0036	0.0033
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0053	0.0051
Onchocerca volvulus		0.0007	0.0042	0.0096
Loa Loa (eye worm)	hypothetical protein	0.001	0.0124	0.0131
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0006	0.0021	0.0022
Loa Loa (eye worm)	MH1 domain-containing protein	0.0008	0.0082	0.0087
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0007	0.0042	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0018	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0215	0.4605	0.4879
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.009	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0164	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0005	0.0005
Brugia malayi	hypothetical protein	0.0006	0.0021	0.0022
Schistosoma mansoni	dishevelled	0.0009	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0021	0.0022
Loa Loa (eye worm)	MH2 domain-containing protein	0.0008	0.0082	0.0087
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0124	0.0126
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0005	0.0018	0.0014
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0124	0.0131
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0012	0.0164	0.0174
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0053	0.0051
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0009	0.0091	0.0096
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0006	0.0036	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0018	0.0019
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0006	0.0021	0.0022
Brugia malayi	MH2 domain containing protein	0.0008	0.0082	0.0087
Echinococcus granulosus	ras GTP exchange factor	0.0006	0.0036	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0072	0.148	0.1568
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0178	0.3803	1
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0012	0.0164	0.0174
Echinococcus multilocularis	musashi	0.0028	0.0506	0.0531
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0018	0.0019
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0012	0.0164	0.0169
Onchocerca volvulus		0.0006	0.0021	0.0042
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0124	0.0126
Trichomonas vaginalis	penicillin-binding protein, putative	0.0072	0.148	1
Schistosoma mansoni	ras GTP exchange factor	0.0006	0.0036	0.0033
Echinococcus granulosus	regulator of G protein signaling 7	0.0009	0.0091	0.0091
Brugia malayi	hypothetical protein	0.0009	0.0091	0.0096
Echinococcus multilocularis	GPCR, family 2	0.0068	0.1388	0.1466
Schistosoma mansoni	dep domain containing protein	0.0009	0.0091	0.0091
Brugia malayi	MH1 domain containing protein	0.0008	0.0082	0.0087
Echinococcus granulosus	rap guanine nucleotide exchange factor 6	0.0006	0.0036	0.0033
Schistosoma mansoni	intermediate filament proteins	0.0028	0.0506	0.0531
Brugia malayi	orphan nuclear receptor NR2E1	0.0005	0.0005	0.0005
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0124	0.0131
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0068	0.1388	0.1466
Onchocerca volvulus		0.0028	0.0518	0.1352
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0005	0.0005
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0124	0.0126
Brugia malayi	steroid hormone receptor	0.001	0.0124	0.0131
Echinococcus granulosus	nAChR subunit	0.0012	0.0164	0.0169
Schistosoma mansoni	acetylcholine receptor-related	0.0006	0.0021	0.0017
Loa Loa (eye worm)	transcription factor SMAD2	0.0123	0.2587	0.2742
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0012	0.0164	0.0169
Brugia malayi	Cation transporter family protein	0.0081	0.167	0.1769
Plasmodium vivax	hypothetical protein, conserved	0.0072	0.148	0.5
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0506	0.0536
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1388	0.147
Schistosoma mansoni	cpg binding protein	0.0028	0.0518	0.0544
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0012	0.0164	0.0169
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0082	0.0082
Brugia malayi	tailless protein	0.0005	0.0005	0.0005
Echinococcus granulosus	glycine receptor subunit beta	0.0012	0.0164	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0147	0.3116	0.3301
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0005	0.0018	0.0014
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0124	0.0131
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0007	0.0042	0.0044
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0012	0.0164	0.0174
Brugia malayi	hypothetical protein	0.0005	0.0018	0.0019
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0006	0.0021	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0164	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0042	0.0044
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0006	0.0036	0.0033
Echinococcus granulosus	Protein son of sevenless	0.0006	0.0036	0.0033
Brugia malayi	beta-lactamase family protein	0.0072	0.148	0.1568
Echinococcus multilocularis	cpg binding protein	0.003	0.0554	0.0582
Echinococcus granulosus	intermediate filament protein	0.0028	0.0506	0.0531
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0124	0.0131
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0012	0.0164	0.0169
Onchocerca volvulus	Protein ultraspiracle homolog	0.001	0.0124	0.0313
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0012	0.0164	0.0174
Mycobacterium leprae	Probable lipase LipE	0.0072	0.148	0.5
Echinococcus multilocularis	smad	0.0008	0.0082	0.0082
Toxoplasma gondii	hypothetical protein	0.0009	0.0091	0.0515
Onchocerca volvulus		0.001	0.0124	0.0313
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0012	0.0164	0.0174
Schistosoma mansoni	hypothetical protein	0.0167	0.3564	0.3773
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0054	0.1073	0.7222
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0518	0.0549
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0039	0.0024
Brugia malayi	ecdysteroid receptor	0.001	0.0124	0.0131
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0012	0.0164	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0021	0.0022
Echinococcus granulosus	rap guanine nucleotide exchange factor 1	0.0006	0.0036	0.0033
Onchocerca volvulus	Segment polarity protein dishevelled homolog	0.0009	0.0091	0.0226
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0009	0.0091	0.0096
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0012	0.0164	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0072	0.148	0.1568
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0068	0.1388	0.147
Echinococcus multilocularis	rap guanine nucleotide exchange factor 1	0.0006	0.0036	0.0033
Loa Loa (eye worm)	camk/mapkapk/mapkapk protein kinase	0.0435	0.9438	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0068	0.1388	0.1466
Loa Loa (eye worm)	hypothetical protein	0.001	0.0124	0.0131
Schistosoma mansoni	guanine-nucleotide-exchange-factor	0.0006	0.0036	0.0033
Brugia malayi	beta-lactamase	0.0072	0.148	0.1568
Loa Loa (eye worm)	Smad1	0.0008	0.0082	0.0087
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0006	0.0021	0.0017
Onchocerca volvulus		0.0072	0.148	0.3883
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0005	0.0016	0.0011
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0005	0.0018	0.0019
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0124	0.0126
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0124	0.0131
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0124	0.0126
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0124	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0192	0.0203
Echinococcus granulosus	glycine receptor subunit beta	0.0012	0.0164	0.0169
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0005	0.0016	0.0011
Echinococcus granulosus	beta LACTamase domain containing family member	0.0072	0.148	0.1563
Brugia malayi	RasGEF domain containing protein	0.0006	0.0036	0.0038
Brugia malayi	RasGEF domain containing protein	0.0006	0.0036	0.0038
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0124	0.0131
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0012	0.0164	0.0169
Echinococcus multilocularis	regulator of G protein signaling 7	0.0009	0.0091	0.0091
Schistosoma mansoni	nAChR subunit	0.0012	0.0164	0.0169
Brugia malayi	nuclear receptor NHR-67	0.0005	0.0005	0.0005
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0124	0.0126
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0124	0.0126
Brugia malayi	conserved hypotetical protein	0.0005	0.0005	0.0005
Loa Loa (eye worm)	ACC-1 protein	0.0012	0.0164	0.0174
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0081	0.167	0.1765
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0164	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0164	0.0174
Brugia malayi	nuclear receptor RXR	0.0005	0.0005	0.0005
Brugia malayi	nuclear hormone receptor family member odr-7	0.0005	0.0005	0.0005
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0006	0.0021	0.0017
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0012	0.0164	0.0174
Trichomonas vaginalis	esterase, putative	0.0072	0.148	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0124	0.0126
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0012	0.0164	0.0174
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0072	0.148	0.5
Brugia malayi	excitatory GABA receptor EXP-1A	0.0012	0.0164	0.0174
Toxoplasma gondii	ABC1 family protein	0.0072	0.148	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0124	0.0131
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0006	0.0021	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0178	0.3803	0.403
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0021	0.0022
Brugia malayi	hypothetical protein	0.0005	0.0005	0.0005
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0506	0.0536
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0012	0.0164	0.0169
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0068	0.1388	0.1466
Brugia malayi	DIX domain containing protein	0.0009	0.0091	0.0096
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0124	0.0126
Trypanosoma brucei	hypothetical protein, conserved	0.0072	0.148	0.5
Entamoeba histolytica	protein kinase, putative	0.0047	0.0928	1
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0012	0.0164	0.0169
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0081	0.167	0.1765
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0021	0.0022
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0012	0.0164	0.0174
Echinococcus granulosus	segment polarity protein dishevelled	0.0009	0.0091	0.0091
Brugia malayi	nuclear receptor RXR	0.0005	0.0018	0.0019
Echinococcus granulosus	segment polarity protein dishevelled	0.0009	0.0091	0.0091
Brugia malayi	MH1 domain containing protein	0.0008	0.0082	0.0087
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0008	0.0082	0.0082
Loa Loa (eye worm)	ACC-1 protein	0.0012	0.0164	0.0174
Entamoeba histolytica	protein kinase, putative	0.0047	0.0928	1
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.0192	0.0198
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0124	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0181	0.0191
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.001	0.0124	0.0313
Schistosoma mansoni	hypothetical protein	0.0068	0.1388	0.1466
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0036	0.0038
Brugia malayi	hypothetical protein	0.0005	0.0018	0.0019
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0012	0.0164	0.0169
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0124	0.0126
Echinococcus multilocularis	segment polarity protein dishevelled	0.0009	0.0091	0.0091
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0006	0.0021	0.0022
Schistosoma mansoni	nAChR subunit	0.0006	0.0021	0.0017
Schistosoma mansoni	cpg binding protein	0.003	0.0554	0.0582
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0082	0.0082
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0006	0.0036	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0021	0.0022
Onchocerca volvulus		0.0028	0.0506	0.1319
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0006	0.0039	0.0024
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0006	0.0021	0.0017
Echinococcus granulosus	MAP kinase activated protein kinase 2	0.0435	0.9438	1
Entamoeba histolytica	hypothetical protein	0.0007	0.0042	0.0066
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0124	0.0131
Brugia malayi	beta-lactamase family protein	0.0072	0.148	0.1568
Brugia malayi	Nuclear hormone receptor E75	0.0005	0.0005	0.0005
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0124	0.0131
Trypanosoma cruzi	hypothetical protein, conserved	0.0072	0.148	1
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0005	0.0005
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0124	0.0131
Loa Loa (eye worm)	LGC-31 protein	0.0012	0.0164	0.0174
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0072	0.148	0.1568
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0018	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0005	0.0005
Trichomonas vaginalis	penicillin-binding protein, putative	0.0072	0.148	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0124	0.0126
Brugia malayi	Latrophilin receptor protein 2	0.0068	0.1388	0.147
Echinococcus multilocularis	glycine receptor subunit beta	0.0012	0.0164	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0042	0.0044
Brugia malayi	Cation transporter family protein	0.0012	0.0164	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0164	0.0174
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0012	0.0164	0.0169
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0012	0.0164	0.0174
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0068	0.1388	0.147
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0124	0.0131
Trichomonas vaginalis	D-aminoacylase, putative	0.0072	0.148	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0124	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0021	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0042	0.0044
Brugia malayi	MH2 domain containing protein	0.0123	0.2587	0.2742
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0005	0.0005	0.0005
Schistosoma mansoni	nAChR subunit	0.0012	0.0164	0.0169
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0124	0.0126
Onchocerca volvulus		0.0012	0.0164	0.0419
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0164	0.0174
Loa Loa (eye worm)	hypothetical protein	0.001	0.0124	0.0131
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0124	0.0126
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0012	0.0164	0.0169
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase I	0.0047	0.0928	0.0978
Schistosoma mansoni	hypothetical protein	0.0068	0.1388	0.1466
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0072	0.148	0.1563
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0164	0.0174
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0072	0.148	0.1563
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.0192	0.0198
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0018	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0072	0.148	0.1568
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0005	0.0005
Onchocerca volvulus		0.0081	0.167	0.4383
Schistosoma mansoni	nAChR subunit	0.0012	0.0164	0.0169
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0039	0.0024
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0006	0.0021	0.0022
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0012	0.0164	0.0169
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0124	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0042	0.0044
Trypanosoma cruzi	hypothetical protein, conserved	0.0072	0.148	1
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0124	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0021	0.0022
Brugia malayi	latrophilin 2 splice variant baaae	0.0147	0.3116	0.3301
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0124	0.0126
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0006	0.0036	0.0038
Schistosoma mansoni	nAChR subunit	0.0012	0.0164	0.0169
Brugia malayi	Nuclear hormone receptor E75	0.0005	0.0005	0.0005
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0007	0.0042	0.0039
Echinococcus multilocularis	geminin	0.0167	0.3564	0.3773
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0164	0.0174
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0012	0.0164	0.0169
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0005	0.0016	0.0011
Schistosoma mansoni	fyve finger-containing phosphoinositide kinase fyv1	0.0009	0.0091	0.0091
Echinococcus granulosus	calcium:calmodulin dependent protein kinase I	0.0047	0.0928	0.0978
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.009	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0164	0.0174
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0005	0.0018	0.0014
Echinococcus multilocularis	Protein son of sevenless	0.0006	0.0036	0.0033
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0008	0.0082	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0021	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0021	0.0022
Echinococcus granulosus	serine:threonine protein kinase Chk2	0.0047	0.0928	0.0979
Loa Loa (eye worm)	hypothetical protein	0.001	0.0124	0.0131
Schistosoma mansoni	hypothetical protein	0.0147	0.3116	0.3298
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0012	0.0164	0.0174
Schistosoma mansoni	neurotransmitter gated ion channel	0.0007	0.0042	0.0039
Onchocerca volvulus		0.0006	0.0036	0.0081
Schistosoma mansoni	regulator of G protein signaling	0.0009	0.0091	0.0091
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0012	0.0164	0.0169
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0012	0.0164	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0181	0.0191
Onchocerca volvulus		0.0007	0.0042	0.0096
Brugia malayi	cytoplasmic intermediate filament protein	0.0015	0.0224	0.0237
Schistosoma mansoni	serine/threonine protein kinase	0.0005	0.0016	0.0011
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0215	0.4605	0.4879
Schistosoma mansoni	smad	0.0008	0.0082	0.0082
Echinococcus multilocularis	lamin	0.0028	0.0506	0.0531
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0124	0.0126
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0012	0.0164	0.0169
Schistosoma mansoni	hypothetical protein	0.0068	0.1388	0.1466
Onchocerca volvulus	Putative nachr subunit	0.0012	0.0164	0.0419
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0012	0.0164	0.0174
Leishmania major	hypothetical protein, conserved	0.0072	0.148	1
Trichomonas vaginalis	helicase, putative	0.0006	0.0039	0.0024
Echinococcus granulosus	smad	0.0008	0.0082	0.0082
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0124	0.0126
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0012	0.0164	0.0169
Loa Loa (eye worm)	DR-78	0.0005	0.0005	0.0005
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0039	0.0024
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0005	0.0005	0.0005
Schistosoma mansoni	nAChR subunit	0.0012	0.0164	0.0169
Schistosoma mansoni	lamin	0.0028	0.0506	0.0531
Brugia malayi	hypothetical protein	0.0006	0.0021	0.0022
Onchocerca volvulus	Bile acid receptor homolog	0.001	0.0124	0.0313
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0012	0.0164	0.0169
Echinococcus multilocularis	Smad4	0.0008	0.0082	0.0082
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0039	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0091	0.0096
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0009	0.0091	0.0096
Brugia malayi	nuclear hormone receptor	0.0005	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.001	0.0124	0.0131
Echinococcus multilocularis	regulator of G protein signaling 7	0.0009	0.0091	0.0091
Brugia malayi	hypothetical protein	0.0006	0.0021	0.0022
Schistosoma mansoni	Smad4	0.0008	0.0082	0.0082
Brugia malayi	map kinase activated protein kinase protein 2	0.0435	0.9438	1
Schistosoma mansoni	coup transcription factor	0.001	0.0124	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0164	0.0174
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0124	0.0126
Onchocerca volvulus		0.0006	0.0021	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0072	0.148	0.1568
Echinococcus granulosus	cGMP dependent protein kinase	0.0005	0.0016	0.0011
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0012	0.0164	0.0174
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0012	0.0164	0.0169
Onchocerca volvulus		0.0006	0.0021	0.0042
Loa Loa (eye worm)	GABA receptor subunit	0.0007	0.0042	0.0044
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0039	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0164	0.0174
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0039	0.0024
Schistosoma mansoni	serine/threonine protein kinase	0.0005	0.0016	0.0011
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0006	0.0036	0.0038
Echinococcus multilocularis	nAChR subunit	0.0012	0.0164	0.0169
Schistosoma mansoni	dishevelled	0.0009	0.0091	0.0091
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0506	0.0536
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0008	0.0082	0.0082
Echinococcus granulosus	regulator of G protein signaling 7	0.0009	0.0091	0.0091
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0006	0.0036	0.0038
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0072	0.148	0.1563
Mycobacterium leprae	conserved hypothetical protein	0.0072	0.148	0.5
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0006	0.0021	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0042	0.0044
Schistosoma mansoni	serine/threonine protein kinase	0.0047	0.0928	0.0979
Echinococcus multilocularis	nAChR subunit	0.0007	0.0042	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0021	0.0022
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0006	0.0036	0.0033
Brugia malayi	hypothetical protein	0.0009	0.0091	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0021	0.0022
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0006	0.0021	0.0022
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0012	0.0164	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0164	0.0174
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0215	0.4605	0.4879
Loa Loa (eye worm)	hypothetical protein	0.0072	0.148	0.1568
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0164	0.0174
Echinococcus multilocularis	Pleckstrin G protein, interacting region	0.0009	0.0091	0.0091
Echinococcus granulosus	lamin	0.0028	0.0506	0.0531
Echinococcus granulosus	cpg binding protein	0.003	0.0554	0.0582
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0012	0.0164	0.0169
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0006	0.0021	0.0017
Mycobacterium ulcerans	hypothetical protein	0.0072	0.148	0.5
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0012	0.0164	0.0174
Echinococcus multilocularis	lamin dm0	0.0028	0.0506	0.0531
Echinococcus multilocularis	expressed conserved protein	0.0005	0.0016	0.0011
Onchocerca volvulus		0.0081	0.167	0.4383
Loa Loa (eye worm)	beta-lactamase	0.0072	0.148	0.1568
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0164	0.0174
Schistosoma mansoni	lamin	0.0028	0.0506	0.0531
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0124	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0021	0.0022
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0012	0.0164	0.0174
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0124	0.0131
Plasmodium falciparum	cGMP-dependent protein kinase	0.0005	0.0016	0.5
Schistosoma mansoni	cpg binding protein	0.003	0.0554	0.0582
Brugia malayi	N-terminal motif family protein	0.0006	0.0036	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0005	0.0005
Brugia malayi	Cation transporter family protein	0.0012	0.0164	0.0174
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0008	0.0082	0.0082
Brugia malayi	nuclear receptor NHR-88	0.0005	0.0005	0.0005
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0124	0.0131
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0124	0.0131
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0068	0.1388	0.1466
Trichomonas vaginalis	D-aminoacylase, putative	0.0072	0.148	1
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0007	0.0042	0.0039
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0124	0.0126

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.4 uM	Inhibition of MAPKAP-K2 using KKLNRTLSVA as substrate and [33P]-gamma-ATP after 30 mins by liquid scintillation counter	ChEMBL.	22746295

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2163628

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1678432