Detailed information for compound 1683134

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 380.487 | Formula: C21H28N6O
  • H donors: 2 H acceptors: 2 LogP: 3.48 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1)Nc1c(C)c(nc2n1ncc2)N(C1CCCNC1)C
  • InChi: 1S/C21H28N6O/c1-4-28-18-9-7-16(8-10-18)24-21-15(2)20(25-19-11-13-23-27(19)21)26(3)17-6-5-12-22-14-17/h7-11,13,17,22,24H,4-6,12,14H2,1-3H3
  • InChiKey: MQDBEPPETPSXJD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0124 0.0131
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0068 0.1388 0.1466
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.148 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0124 0.0126
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0007 0.0042 0.0039
Schistosoma mansoni cpg binding protein 0.003 0.0554 0.0582
Brugia malayi N-terminal motif family protein 0.0006 0.0036 0.0038
Loa Loa (eye worm) hypothetical protein 0.0005 0.0005 0.0005
Brugia malayi Cation transporter family protein 0.0012 0.0164 0.0174
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0082 0.0082
Brugia malayi nuclear receptor NHR-88 0.0005 0.0005 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0124 0.0131
Onchocerca volvulus 0.0081 0.167 0.4383
Loa Loa (eye worm) beta-lactamase 0.0072 0.148 0.1568
Loa Loa (eye worm) hypothetical protein 0.0012 0.0164 0.0174
Schistosoma mansoni lamin 0.0028 0.0506 0.0531
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0124 0.0126
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0022
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0012 0.0164 0.0174
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0124 0.0131
Plasmodium falciparum cGMP-dependent protein kinase 0.0005 0.0016 0.5
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0091 0.0091
Echinococcus granulosus lamin 0.0028 0.0506 0.0531
Echinococcus granulosus cpg binding protein 0.003 0.0554 0.0582
Echinococcus granulosus glycine receptor subunit alpha 1 0.0012 0.0164 0.0169
Schistosoma mansoni acetylcholine receptor subunit beta 0.0006 0.0021 0.0017
Mycobacterium ulcerans hypothetical protein 0.0072 0.148 0.5
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0012 0.0164 0.0174
Echinococcus multilocularis lamin dm0 0.0028 0.0506 0.0531
Echinococcus multilocularis expressed conserved protein 0.0005 0.0016 0.0011
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0022
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0006 0.0021 0.0022
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0012 0.0164 0.0169
Loa Loa (eye worm) hypothetical protein 0.0012 0.0164 0.0174
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0215 0.4605 0.4879
Loa Loa (eye worm) hypothetical protein 0.0072 0.148 0.1568
Loa Loa (eye worm) hypothetical protein 0.0012 0.0164 0.0174
Loa Loa (eye worm) hypothetical protein 0.0007 0.0042 0.0044
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.0928 0.0979
Echinococcus multilocularis nAChR subunit 0.0007 0.0042 0.0039
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0022
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0036 0.0033
Brugia malayi hypothetical protein 0.0009 0.0091 0.0096
Echinococcus multilocularis nAChR subunit 0.0012 0.0164 0.0169
Schistosoma mansoni dishevelled 0.0009 0.0091 0.0091
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0506 0.0536
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0082 0.0082
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.0036 0.0038
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.148 0.1563
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0091 0.0091
Mycobacterium leprae conserved hypothetical protein 0.0072 0.148 0.5
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0006 0.0021 0.0022
Onchocerca volvulus 0.0006 0.0021 0.0042
Loa Loa (eye worm) GABA receptor subunit 0.0007 0.0042 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0039 0.0024
Loa Loa (eye worm) hypothetical protein 0.0012 0.0164 0.0174
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0039 0.0024
Schistosoma mansoni serine/threonine protein kinase 0.0005 0.0016 0.0011
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.0036 0.0038
Schistosoma mansoni coup transcription factor 0.001 0.0124 0.0126
Brugia malayi map kinase activated protein kinase protein 2 0.0435 0.9438 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0164 0.0174
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0124 0.0126
Onchocerca volvulus 0.0006 0.0021 0.0042
Loa Loa (eye worm) hypothetical protein 0.0072 0.148 0.1568
Echinococcus granulosus cGMP dependent protein kinase 0.0005 0.0016 0.0011
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0012 0.0164 0.0174
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0012 0.0164 0.0169
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0124 0.0313
Echinococcus multilocularis Smad4 0.0008 0.0082 0.0082
Echinococcus granulosus glycine receptor subunit alpha 1 0.0012 0.0164 0.0169
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0039 0.0024
Loa Loa (eye worm) hypothetical protein 0.0009 0.0091 0.0096
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0091 0.0096
Brugia malayi nuclear hormone receptor 0.0005 0.0005 0.0005
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.001 0.0124 0.0131
Schistosoma mansoni Smad4 0.0008 0.0082 0.0082
Brugia malayi hypothetical protein 0.0006 0.0021 0.0022
Echinococcus granulosus smad 0.0008 0.0082 0.0082
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0124 0.0126
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0012 0.0164 0.0169
Loa Loa (eye worm) DR-78 0.0005 0.0005 0.0005
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0039 0.0024
Schistosoma mansoni lamin 0.0028 0.0506 0.0531
Brugia malayi nuclear hormone receptor family member nhr-6 0.0005 0.0005 0.0005
Schistosoma mansoni nAChR subunit 0.0012 0.0164 0.0169
Brugia malayi hypothetical protein 0.0006 0.0021 0.0022
Echinococcus multilocularis lamin 0.0028 0.0506 0.0531
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0124 0.0126
Schistosoma mansoni hypothetical protein 0.0068 0.1388 0.1466
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0012 0.0164 0.0169
Onchocerca volvulus Putative nachr subunit 0.0012 0.0164 0.0419
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0012 0.0164 0.0174
Leishmania major hypothetical protein, conserved 0.0072 0.148 1
Trichomonas vaginalis helicase, putative 0.0006 0.0039 0.0024
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0091 0.0091
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0012 0.0164 0.0169
Loa Loa (eye worm) hypothetical protein 0.0013 0.0181 0.0191
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0012 0.0164 0.0169
Onchocerca volvulus 0.0007 0.0042 0.0096
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0224 0.0237
Schistosoma mansoni serine/threonine protein kinase 0.0005 0.0016 0.0011
Brugia malayi Calcitonin receptor-like protein seb-1 0.0215 0.4605 0.4879
Schistosoma mansoni smad 0.0008 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0022
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0082 0.0082
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0047 0.0928 0.0979
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0022
Loa Loa (eye worm) hypothetical protein 0.001 0.0124 0.0131
Schistosoma mansoni hypothetical protein 0.0147 0.3116 0.3298
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0012 0.0164 0.0174
Schistosoma mansoni neurotransmitter gated ion channel 0.0007 0.0042 0.0039
Onchocerca volvulus 0.0006 0.0036 0.0081
Echinococcus multilocularis geminin 0.0167 0.3564 0.3773
Loa Loa (eye worm) hypothetical protein 0.0012 0.0164 0.0174
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0012 0.0164 0.0169
Echinococcus granulosus cGMP dependent protein kinase 1 0.0005 0.0016 0.0011
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0091 0.0091
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0047 0.0928 0.0978
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.009 0.0091
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0005 0.0018 0.0014
Loa Loa (eye worm) hypothetical protein 0.0012 0.0164 0.0174
Echinococcus multilocularis Protein son of sevenless 0.0006 0.0036 0.0033
Brugia malayi latrophilin 2 splice variant baaae 0.0147 0.3116 0.3301
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0124 0.0126
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.0036 0.0038
Schistosoma mansoni nAChR subunit 0.0012 0.0164 0.0169
Brugia malayi Nuclear hormone receptor E75 0.0005 0.0005 0.0005
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0007 0.0042 0.0039
Schistosoma mansoni nAChR subunit 0.0012 0.0164 0.0169
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0039 0.0024
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0006 0.0021 0.0022
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0012 0.0164 0.0169
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0124 0.0131
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.148 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0042 0.0044
Schistosoma mansoni thyroid hormone receptor 0.001 0.0124 0.0126
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0022
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.148 0.1563
Loa Loa (eye worm) hypothetical protein 0.0012 0.0164 0.0174
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0192 0.0198
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.148 0.1563
Loa Loa (eye worm) hypothetical protein 0.0072 0.148 0.1568
Loa Loa (eye worm) hypothetical protein 0.0005 0.0018 0.0019
Loa Loa (eye worm) hypothetical protein 0.0005 0.0005 0.0005
Onchocerca volvulus 0.0081 0.167 0.4383
Loa Loa (eye worm) hypothetical protein 0.0012 0.0164 0.0174
Loa Loa (eye worm) hypothetical protein 0.001 0.0124 0.0131
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0124 0.0126
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0012 0.0164 0.0169
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0047 0.0928 0.0978
Schistosoma mansoni hypothetical protein 0.0068 0.1388 0.1466
Loa Loa (eye worm) hypothetical protein 0.0007 0.0042 0.0044
Brugia malayi MH2 domain containing protein 0.0123 0.2587 0.2742
Loa Loa (eye worm) nuclear receptor NHR-67 0.0005 0.0005 0.0005
Schistosoma mansoni nAChR subunit 0.0012 0.0164 0.0169
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0124 0.0126
Onchocerca volvulus 0.0012 0.0164 0.0419
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0124 0.0131
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.148 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0124 0.0126
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0022
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.148 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0124 0.0126
Brugia malayi Latrophilin receptor protein 2 0.0068 0.1388 0.147
Echinococcus multilocularis glycine receptor subunit beta 0.0012 0.0164 0.0169
Loa Loa (eye worm) hypothetical protein 0.0007 0.0042 0.0044
Brugia malayi Cation transporter family protein 0.0012 0.0164 0.0174
Loa Loa (eye worm) hypothetical protein 0.0012 0.0164 0.0174
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0012 0.0164 0.0169
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0012 0.0164 0.0174
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0068 0.1388 0.147
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.148 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.0005 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0124 0.0131
Loa Loa (eye worm) LGC-31 protein 0.0012 0.0164 0.0174
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.148 0.1568
Loa Loa (eye worm) hypothetical protein 0.0005 0.0018 0.0019
Loa Loa (eye worm) hypothetical protein 0.0005 0.0005 0.0005
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0039 0.0024
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0006 0.0021 0.0017
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0435 0.9438 1
Entamoeba histolytica hypothetical protein 0.0007 0.0042 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0124 0.0131
Brugia malayi Nuclear hormone receptor E75 0.0005 0.0005 0.0005
Brugia malayi beta-lactamase family protein 0.0072 0.148 0.1568
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0124 0.0131
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0124 0.0126
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0091 0.0091
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0006 0.0021 0.0022
Schistosoma mansoni nAChR subunit 0.0006 0.0021 0.0017
Schistosoma mansoni cpg binding protein 0.003 0.0554 0.0582
Schistosoma mansoni smad1 5 8 and 0.0008 0.0082 0.0082
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0036 0.0033
Onchocerca volvulus 0.0028 0.0506 0.1319
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0022
Loa Loa (eye worm) hypothetical protein 0.0006 0.0036 0.0038
Brugia malayi hypothetical protein 0.0005 0.0018 0.0019
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0012 0.0164 0.0169
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0082 0.0082
Brugia malayi MH1 domain containing protein 0.0008 0.0082 0.0087
Loa Loa (eye worm) ACC-1 protein 0.0012 0.0164 0.0174
Entamoeba histolytica protein kinase, putative 0.0047 0.0928 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0192 0.0198
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0124 0.0131
Loa Loa (eye worm) hypothetical protein 0.0013 0.0181 0.0191
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0124 0.0313
Schistosoma mansoni hypothetical protein 0.0068 0.1388 0.1466
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0012 0.0164 0.0169
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0081 0.167 0.1765
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0164 0.0174
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0022
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0091 0.0091
Brugia malayi nuclear receptor RXR 0.0005 0.0018 0.0019
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0178 0.3803 0.403
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0022
Brugia malayi hypothetical protein 0.0005 0.0005 0.0005
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0506 0.0536
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0012 0.0164 0.0169
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0068 0.1388 0.1466
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0124 0.0126
Brugia malayi DIX domain containing protein 0.0009 0.0091 0.0096
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.148 0.5
Entamoeba histolytica protein kinase, putative 0.0047 0.0928 1
Toxoplasma gondii ABC1 family protein 0.0072 0.148 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.148 0.5
Brugia malayi excitatory GABA receptor EXP-1A 0.0012 0.0164 0.0174
Loa Loa (eye worm) hypothetical protein 0.001 0.0124 0.0131
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0006 0.0021 0.0022
Brugia malayi conserved hypotetical protein 0.0005 0.0005 0.0005
Loa Loa (eye worm) ACC-1 protein 0.0012 0.0164 0.0174
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0081 0.167 0.1765
Loa Loa (eye worm) hypothetical protein 0.0012 0.0164 0.0174
Brugia malayi nuclear receptor RXR 0.0005 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0164 0.0174
Brugia malayi nuclear hormone receptor family member odr-7 0.0005 0.0005 0.0005
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0006 0.0021 0.0017
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0012 0.0164 0.0174
Trichomonas vaginalis esterase, putative 0.0072 0.148 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0124 0.0126
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0012 0.0164 0.0174
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0005 0.0016 0.0011
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.148 0.1563
Brugia malayi RasGEF domain containing protein 0.0006 0.0036 0.0038
Brugia malayi RasGEF domain containing protein 0.0006 0.0036 0.0038
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0124 0.0131
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0012 0.0164 0.0169
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0091 0.0091
Schistosoma mansoni nAChR subunit 0.0012 0.0164 0.0169
Brugia malayi nuclear receptor NHR-67 0.0005 0.0005 0.0005
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0124 0.0126
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0124 0.0126
Loa Loa (eye worm) hypothetical protein 0.001 0.0124 0.0131
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0006 0.0036 0.0033
Brugia malayi beta-lactamase 0.0072 0.148 0.1568
Loa Loa (eye worm) Smad1 0.0008 0.0082 0.0087
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0006 0.0021 0.0017
Onchocerca volvulus 0.0072 0.148 0.3883
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0005 0.0016 0.0011
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0005 0.0018 0.0019
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0124 0.0126
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0124 0.0131
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0124 0.0126
Loa Loa (eye worm) hypothetical protein 0.0013 0.0192 0.0203
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0124 0.0131
Echinococcus granulosus glycine receptor subunit beta 0.0012 0.0164 0.0169
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0006 0.0036 0.0033
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0009 0.0091 0.0226
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0091 0.0096
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0012 0.0164 0.0169
Loa Loa (eye worm) hypothetical protein 0.0072 0.148 0.1568
Loa Loa (eye worm) latrophilin receptor protein 2 0.0068 0.1388 0.147
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0435 0.9438 1
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0006 0.0036 0.0033
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0068 0.1388 0.1466
Echinococcus multilocularis smad 0.0008 0.0082 0.0082
Toxoplasma gondii hypothetical protein 0.0009 0.0091 0.0515
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0012 0.0164 0.0174
Onchocerca volvulus 0.001 0.0124 0.0313
Schistosoma mansoni hypothetical protein 0.0167 0.3564 0.3773
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.1073 0.7222
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0518 0.0549
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0039 0.0024
Brugia malayi ecdysteroid receptor 0.001 0.0124 0.0131
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0164 0.0174
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0022
Loa Loa (eye worm) hypothetical protein 0.0007 0.0042 0.0044
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0036 0.0033
Brugia malayi beta-lactamase family protein 0.0072 0.148 0.1568
Echinococcus granulosus Protein son of sevenless 0.0006 0.0036 0.0033
Echinococcus multilocularis cpg binding protein 0.003 0.0554 0.0582
Echinococcus granulosus intermediate filament protein 0.0028 0.0506 0.0531
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0124 0.0131
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0012 0.0164 0.0169
Mycobacterium leprae Probable lipase LipE 0.0072 0.148 0.5
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0012 0.0164 0.0174
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0124 0.0313
Schistosoma mansoni cpg binding protein 0.0028 0.0518 0.0544
Echinococcus granulosus glycine receptor subunit alpha 1 0.0012 0.0164 0.0169
Schistosoma mansoni smad1 5 8 and 0.0008 0.0082 0.0082
Brugia malayi tailless protein 0.0005 0.0005 0.0005
Echinococcus granulosus glycine receptor subunit beta 0.0012 0.0164 0.0169
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0005 0.0018 0.0014
Loa Loa (eye worm) hypothetical protein 0.0147 0.3116 0.3301
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0124 0.0131
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0007 0.0042 0.0044
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0012 0.0164 0.0174
Brugia malayi hypothetical protein 0.0005 0.0018 0.0019
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0006 0.0021 0.0017
Loa Loa (eye worm) hypothetical protein 0.0012 0.0164 0.0174
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.2587 0.2742
Schistosoma mansoni acetylcholine receptor-related 0.0006 0.0021 0.0017
Echinococcus granulosus nAChR subunit 0.0012 0.0164 0.0169
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0012 0.0164 0.0169
Brugia malayi Cation transporter family protein 0.0081 0.167 0.1769
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0506 0.0536
Plasmodium vivax hypothetical protein, conserved 0.0072 0.148 0.5
Loa Loa (eye worm) hypothetical protein 0.0068 0.1388 0.147
Schistosoma mansoni intermediate filament proteins 0.0028 0.0506 0.0531
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0124 0.0131
Brugia malayi orphan nuclear receptor NR2E1 0.0005 0.0005 0.0005
Onchocerca volvulus 0.0028 0.0518 0.1352
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0068 0.1388 0.1466
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0124 0.0126
Brugia malayi steroid hormone receptor 0.001 0.0124 0.0131
Loa Loa (eye worm) hypothetical protein 0.0005 0.0005 0.0005
Schistosoma mansoni ras GTP exchange factor 0.0006 0.0036 0.0033
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0091 0.0091
Brugia malayi hypothetical protein 0.0009 0.0091 0.0096
Echinococcus multilocularis GPCR, family 2 0.0068 0.1388 0.1466
Schistosoma mansoni dep domain containing protein 0.0009 0.0091 0.0091
Brugia malayi MH1 domain containing protein 0.0008 0.0082 0.0087
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0006 0.0036 0.0033
Loa Loa (eye worm) hypothetical protein 0.0005 0.0018 0.0019
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0012 0.0164 0.0169
Onchocerca volvulus 0.0006 0.0021 0.0042
Echinococcus granulosus FTZ F1 alpha 0.001 0.0124 0.0126
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.148 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.0018 0.0019
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0006 0.0021 0.0022
Brugia malayi MH2 domain containing protein 0.0008 0.0082 0.0087
Echinococcus granulosus ras GTP exchange factor 0.0006 0.0036 0.0033
Loa Loa (eye worm) hypothetical protein 0.0072 0.148 0.1568
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0178 0.3803 1
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0012 0.0164 0.0174
Echinococcus multilocularis musashi 0.0028 0.0506 0.0531
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0022
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0124 0.0126
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0082 0.0087
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0005 0.0018 0.0014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0124 0.0131
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0164 0.0174
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0053 0.0051
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0091 0.0096
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0006 0.0036 0.0081
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0006 0.0021 0.0022
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0082 0.0087
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0007 0.0042 0.0044
Loa Loa (eye worm) hypothetical protein 0.0215 0.4605 0.4879
Loa Loa (eye worm) hypothetical protein 0.0005 0.0018 0.0019
Loa Loa (eye worm) histone methyltransferase 0.0009 0.009 0.0096
Loa Loa (eye worm) hypothetical protein 0.0012 0.0164 0.0174
Loa Loa (eye worm) hypothetical protein 0.0005 0.0005 0.0005
Brugia malayi hypothetical protein 0.0006 0.0021 0.0022
Schistosoma mansoni dishevelled 0.0009 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0005 0.0005 0.0005
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0005 0.0005 0.0005
Echinococcus granulosus geminin 0.0167 0.3564 0.3773
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0124 0.0126
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0006 0.0021 0.0022
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0039 0.0024
Loa Loa (eye worm) hypothetical protein 0.0009 0.0091 0.0096
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0039 0.0024
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0018 0.0019
Echinococcus multilocularis ras GTP exchange factor 0.0006 0.0036 0.0033
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0053 0.0051
Loa Loa (eye worm) hypothetical protein 0.001 0.0124 0.0131
Onchocerca volvulus 0.0007 0.0042 0.0096
Schistosoma mansoni nuclear hormone receptor 0.001 0.0124 0.0126
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0124 0.0126
Schistosoma mansoni nAChR subunit 0.0012 0.0164 0.0169
Loa Loa (eye worm) hypothetical protein 0.0005 0.0005 0.0005
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0039 0.0024
Loa Loa (eye worm) hypothetical protein 0.0081 0.167 0.1769
Loa Loa (eye worm) AGC/PKG protein kinase 0.0005 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0164 0.0174
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.148 0.1568
Brugia malayi MH2 domain containing protein 0.0008 0.0082 0.0087
Mycobacterium ulcerans beta-lactamase 0.0072 0.148 0.5
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.148 1
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0006 0.0021 0.0017
Loa Loa (eye worm) hypothetical protein 0.0005 0.0005 0.0005
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.001 0.0124 0.0131
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0053 0.0051
Echinococcus granulosus lamin dm0 0.0028 0.0506 0.0531
Schistosoma mansoni hypothetical protein 0.0068 0.1388 0.1466
Loa Loa (eye worm) hypothetical protein 0.0005 0.0005 0.0005
Echinococcus granulosus cGMP dependent protein kinase 1 0.0005 0.0016 0.0011
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0007 0.0042 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0039 0.0024
Schistosoma mansoni hypothetical protein 0.0167 0.3564 0.3773
Onchocerca volvulus 0.0072 0.148 0.3883
Loa Loa (eye worm) acetylcholine receptor protein 0.0006 0.0021 0.0022
Brugia malayi nuclear receptor NHR-88 0.001 0.0124 0.0131
Echinococcus multilocularis glycine receptor subunit beta 0.0012 0.0164 0.0169
Loa Loa (eye worm) hypothetical protein 0.0009 0.0091 0.0096
Schistosoma mansoni serine/threonine protein kinase 0.0435 0.9438 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0495 0.0524
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0088 0.0093
Echinococcus multilocularis son of sevenless 1 0.0006 0.0036 0.0033
Schistosoma mansoni neurotransmitter gated ion channel 0.0006 0.0021 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0124 0.0131
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0124 0.0126
Brugia malayi nuclear hormone receptor 0.001 0.0124 0.0131
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0012 0.0164 0.0169
Loa Loa (eye worm) hypothetical protein 0.0028 0.0506 0.0536
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.2587 0.2742
Schistosoma mansoni nAChR subunit 0.0012 0.0164 0.0169
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0012 0.0164 0.0174
Schistosoma mansoni smad1 5 8 and 0.0008 0.0082 0.0082
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0124 0.0126
Loa Loa (eye worm) hypothetical protein 0.0005 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0022
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.009 0.0091
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0124 0.0126
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0124 0.0131
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0224 0.0237
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0012 0.0164 0.0174
Loa Loa (eye worm) hypothetical protein 0.0081 0.167 0.1769
Loa Loa (eye worm) hypothetical protein 0.0005 0.0005 0.0005
Brugia malayi RasGEF domain containing protein 0.0006 0.0036 0.0038
Brugia malayi Egg laying defective protein 4 0.0005 0.0016 0.0016
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0005 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0007 0.0042 0.0044
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0012 0.0164 0.0169
Loa Loa (eye worm) hypothetical protein 0.0072 0.148 0.1568
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0091 0.0096
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0022
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0435 0.9438 1
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0012 0.0164 0.0174
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0018 0.0019
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0012 0.0164 0.0174
Loa Loa (eye worm) hypothetical protein 0.001 0.0124 0.0131
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0124 0.0131
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0091 0.0091
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0039 0.0024
Brugia malayi hypothetical protein 0.0006 0.0021 0.0022
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0012 0.0164 0.0174
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0164 0.0174
Brugia malayi ecdysone receptor 0.0005 0.0005 0.0005
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0006 0.0029 0.0026
Brugia malayi hypothetical protein 0.0006 0.0021 0.0022
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0124 0.0126
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0215 0.4605 0.4879
Loa Loa (eye worm) hypothetical protein 0.0012 0.0164 0.0174
Loa Loa (eye worm) hypothetical protein 0.0006 0.0021 0.0022
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0012 0.0164 0.0169
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0005 0.0018 0.0014
Echinococcus granulosus GPCR family 2 0.0068 0.1388 0.1466
Brugia malayi N-terminal motif family protein 0.0006 0.0036 0.0038
Loa Loa (eye worm) hypothetical protein 0.0007 0.0042 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0124 0.0131
Echinococcus granulosus Smad4 0.0008 0.0082 0.0082
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0039 0.0024
Loa Loa (eye worm) nuclear hormone receptor 0.0005 0.0005 0.0005
Schistosoma mansoni thyroid hormone receptor 0.001 0.0124 0.0126
Onchocerca volvulus 0.0009 0.0091 0.0226
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0124 0.0131
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0124 0.0131
Onchocerca volvulus 0.0028 0.0506 0.1319
Onchocerca volvulus 0.0081 0.167 0.4383
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0039 0.0024
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0006 0.0036 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0039 0.0024
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0124 0.0126
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0091 0.0091
Onchocerca volvulus 0.0012 0.0164 0.0419
Mycobacterium ulcerans lipase LipD 0.0072 0.148 0.5
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.148 0.5
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.1213 0.1281
Onchocerca volvulus 0.0072 0.148 0.3883
Brugia malayi Smad1 0.0008 0.0082 0.0087
Echinococcus granulosus nAChR subunit 0.0007 0.0042 0.0039
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0053 0.0051
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0053 0.0051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0124 0.0131
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0012 0.0164 0.0169
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0039 0.0024
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0164 0.0174
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0007 0.0042 0.0044
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0047 0.0928 0.0979
Schistosoma mansoni nAChR subunit 0.0006 0.0021 0.0017
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0164 0.0174
Loa Loa (eye worm) hypothetical protein 0.0006 0.0036 0.0038
Brugia malayi hypothetical protein 0.0005 0.0005 0.0005
Schistosoma mansoni serine/threonine protein kinase 0.0005 0.0016 0.0011
Echinococcus granulosus son of sevenless 1 0.0006 0.0036 0.0033
Loa Loa (eye worm) hypothetical protein 0.0007 0.0042 0.0044
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0091 0.0096
Onchocerca volvulus 0.0012 0.0164 0.0419
Loa Loa (eye worm) hypothetical protein 0.0005 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0075 0.1547 0.1639
Brugia malayi N-terminal motif family protein 0.0178 0.3803 0.403
Schistosoma mansoni neurotransmitter gated ion channel 0.0006 0.0021 0.0017
Brugia malayi CXXC zinc finger family protein 0.0028 0.0518 0.0549
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0124 0.0131
Brugia malayi intermediate filament protein 0.0028 0.0506 0.0536
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0039 0.0024

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 26 uM Inhibition of MAPKAP-K2 using KKLNRTLSVA as substrate and [33P]-gamma-ATP after 30 mins by liquid scintillation counter ChEMBL. 22746295

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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