TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 486.627 | Formula: C25H34N4O4S
H donors: 1 H acceptors: 5 LogP: 2.37 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: N#CC1(CC1)NC(=O)[C@@H]1CCCC[C@H]1C(=O)N1[C@H](C)CN(C[C@@H]1C)c1ccc(cc1)S(=O)(=O)C
InChi: 1S/C25H34N4O4S/c1-17-14-28(19-8-10-20(11-9-19)34(3,32)33)15-18(2)29(17)24(31)22-7-5-4-6-21(22)23(30)27-25(16-26)12-13-25/h8-11,17-18,21-22H,4-7,12-15H2,1-3H3,(H,27,30)/t17-,18+,21-,22-/m1/s1
InChiKey: CUJKXZFQTNTDPN-GMQQQROESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin S	Starlite/ChEMBL	References
Homo sapiens	cathepsin K	Starlite/ChEMBL	References
Homo sapiens	cathepsin L	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin S	281 aa	226 aa	34.1 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin L	333 aa	359 aa	30.1 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin K	329 aa	349 aa	33.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0037	0.0334	0.0334
Onchocerca volvulus		0.0086	0.1362	0.1362
Brugia malayi	MH2 domain containing protein	0.0025	0.0082	0.0104
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0059	0.0804	0.0812
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1112	0.1123
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0334	0.0337
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.1362	1
Schistosoma mansoni	acetylcholine receptor-related	0.0037	0.0334	0.0462
Loa Loa (eye worm)	MH2 domain-containing protein	0.0025	0.0082	0.0083
Schistosoma mansoni	nAChR subunit	0.0079	0.1227	0.1696
Brugia malayi	MAP kinase sur-1	0.0053	0.0682	0.0858
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0317	0.5
Toxoplasma gondii	cathepsin B	0.007	0.1024	0.7277
Loa Loa (eye worm)	hypothetical protein	0.0205	0.3853	0.3889
Schistosoma mansoni	hypothetical protein	0.0286	0.5546	0.7666
Brugia malayi	hypothetical protein	0.0026	0.012	0.0151
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.0804	0.466
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0037	0.0334	0.0337
Echinococcus multilocularis	glycine receptor subunit beta	0.0079	0.1227	0.1238
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0079	0.1227	0.1238
Echinococcus multilocularis	carboxylesterase 5A	0.0074	0.1112	0.1123
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0543	0.187
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0317	0.032
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0059	0.0804	0.1211
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0039	0.0377	0.0474
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0079	0.1227	0.1543
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.1362	1
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0804	0.0812
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0079	0.1227	0.1238
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0543	0.187
Brugia malayi	Cathepsin L-like precursor	0.0086	0.1362	0.1714
Echinococcus multilocularis	glycine receptor subunit beta	0.0079	0.1227	0.1238
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	0.0168	0.3083	0.3112
Schistosoma mansoni	hypothetical protein	0.0038	0.0355	0.0491
Entamoeba histolytica	cysteine proteinase 1, putative	0.0047	0.0543	0.187
Onchocerca volvulus		0.0046	0.054	0.054
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0079	0.1227	0.1238
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0334	0.0337
Echinococcus granulosus	carboxylesterase 5A	0.0074	0.1112	0.1123
Echinococcus granulosus	cathepsin L cysteine protease	0.0047	0.0543	0.0549
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1227	0.1238
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0093	0.1511	0.1525
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0059	0.0804	0.0874
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0543	0.187
Loa Loa (eye worm)	hypothetical protein	0.0465	0.9284	0.9371
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0053	0.0682	0.0718
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.1362	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0047	0.0543	0.0541
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	0.0039	0.0378	0.0475
Echinococcus multilocularis	Smad4	0.0025	0.0082	0.0083
Echinococcus granulosus	mitogen activated protein kinase	0.0053	0.0682	0.0689
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0217	0.4091	0.5146
Echinococcus multilocularis	cathepsin L cysteine protease	0.0086	0.1362	0.1375
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0462	0.0467
Schistosoma mansoni	Smad4	0.0025	0.0082	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0465	0.9284	0.9371
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0079	0.1227	0.1543
Trypanosoma cruzi	cysteine peptidase, putative	0.0086	0.1362	0.1587
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0543	0.0541
Echinococcus granulosus	muscleblind protein	0.0156	0.2831	0.2858
Onchocerca volvulus		0.0086	0.1362	0.1362
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0053	0.0682	0.4525
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0059	0.0804	0.1011
Trypanosoma cruzi	cysteine peptidase, putative	0.0086	0.1362	0.1587
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1227	0.1238
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0079	0.1227	0.1238
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0053	0.0674	0.068
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0079	0.1227	0.1238
Loa Loa (eye worm)	ACC-1 protein	0.0079	0.1227	0.1238
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0053	0.0674	0.0931
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0079	0.1227	0.1696
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.1362	0.1587
Trypanosoma brucei	serine peptidase, Clan SC, Family S9B	0.0057	0.0751	0.0806
Trichomonas vaginalis	CMGC family protein kinase	0.0053	0.0682	0.3494
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0027	0.0128	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0462	0.0467
Loa Loa (eye worm)	hypothetical protein	0.0401	0.795	0.8024
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.1362	1
Loa Loa (eye worm)	ctsf protein	0.0086	0.1362	0.1375
Giardia lamblia	Cathepsin B precursor	0.007	0.1024	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1227	0.1238
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1227	0.1238
Schistosoma mansoni	neurotransmitter gated ion channel	0.0043	0.0462	0.0639
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1227	0.1238
Leishmania major	cathepsin L-like protease	0.0086	0.1362	0.1587
Leishmania major	cathepsin L-like protease	0.0086	0.1362	0.1587
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0074	0.1112	0.1537
Plasmodium vivax	unspecified product	0.0047	0.0543	0.3989
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0317	0.0438
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0039	0.0377	0.0521
Entamoeba histolytica	cysteine proteinase, putative	0.0086	0.1362	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0334	0.0337
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0217	0.4091	0.413
Echinococcus granulosus	Lysosomal Pro X carboxypeptidase	0.0367	0.7235	0.7303
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0046	0.054	0.054
Leishmania major	cathepsin L-like protease	0.0086	0.1362	0.1587
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0025	0.0082	0.0114
Schistosoma mansoni	nAChR subunit	0.0037	0.0334	0.0462
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0047	0.0543	0.0751
Onchocerca volvulus		0.0036	0.0317	0.0317
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0093	0.1511	0.2088
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0804	0.1872
Brugia malayi	Cation transporter family protein	0.0079	0.1227	0.1543
Echinococcus granulosus	mothers against decapentaplegic 5	0.0025	0.0082	0.0083
Giardia lamblia	Cathepsin B precursor	0.007	0.1024	1
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0543	0.187
Brugia malayi	MH1 domain containing protein	0.0025	0.0082	0.0104
Loa Loa (eye worm)	cathepsin B	0.007	0.1024	0.1034
Echinococcus granulosus	glycine receptor subunit beta	0.0079	0.1227	0.1238
Brugia malayi	Carboxylesterase family protein	0.0074	0.1112	0.1399
Echinococcus multilocularis	cathepsin b	0.0181	0.3345	0.3376
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0181	0.3345	0.4118
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0093	0.1511	0.1525
Schistosoma mansoni	cathepsin F (C01 family)	0.0086	0.1362	0.1883
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0093	0.1511	0.19
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.1362	1
Echinococcus granulosus	tumor protein p63	0.0353	0.6948	0.7013
Onchocerca volvulus		0.0086	0.1362	0.1362
Onchocerca volvulus		0.0036	0.0317	0.0317
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.1362	0.1587
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0037	0.0334	0.0337
Schistosoma mansoni	serine/threonine protein kinase	0.0053	0.0682	0.0943
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0217	0.4091	0.4129
Loa Loa (eye worm)	ACC-1 protein	0.0079	0.1227	0.1238
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0317	0.0438
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0804	0.1872
Echinococcus multilocularis	neuropeptide receptor A26	0.0495	0.9907	1
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0053	0.0682	0.0688
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0079	0.1227	0.1543
Echinococcus granulosus	neuropeptide receptor A26	0.0495	0.9907	1
Echinococcus granulosus	nAChR subunit	0.0043	0.0462	0.0467
Echinococcus granulosus	nAChR subunit	0.0079	0.1227	0.1238
Echinococcus granulosus	Smad4	0.0025	0.0082	0.0083
Schistosoma mansoni	nAChR subunit	0.0079	0.1227	0.1696
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0079	0.1227	0.1543
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.1362	0.1587
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0037	0.0334	0.0337
Echinococcus granulosus	polycomb protein SCMH1	0.0046	0.054	0.0545
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0086	0.1362	1
Echinococcus granulosus	acetylcholinesterase	0.0074	0.1112	0.1123
Giardia lamblia	Kinase, CMGC MAPK	0.0053	0.0682	0.4716
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1227	0.1238
Brugia malayi	follicle stimulating hormone receptor	0.0254	0.4884	0.6143
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0053	0.0682	0.0689
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0649	0.0655
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0181	0.3345	0.4623
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.1362	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.1362	1
Leishmania major	C-8 sterol isomerase-like protein	0.0401	0.795	1
Echinococcus granulosus	ubiquitin specific protease 41	0.0039	0.0377	0.0381
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.007	0.1024	0.6764
Leishmania major	cathepsin L-like protease	0.0086	0.1362	0.1587
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0079	0.1227	0.1238
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0093	0.1511	0.1525
Brugia malayi	MH2 domain containing protein	0.0025	0.0082	0.0104
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.0543	0.187
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0043	0.0462	0.0581
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0543	0.187
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0674	0.068
Brugia malayi	Cathepsin L-like precursor	0.0086	0.1362	0.1714
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0128	0.0129
Trypanosoma cruzi	cysteine protease, putative	0.0047	0.0543	0.0541
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0543	0.0541
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0043	0.0462	0.0582
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.007	0.1024	0.1155
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0079	0.1227	0.1543
Brugia malayi	hypothetical protein	0.0043	0.0472	0.0594
Plasmodium vivax	vivapain-1	0.0047	0.0543	0.3989
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0037	0.0334	0.042
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0079	0.1227	0.1696
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0317	0.032
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.1362	0.1587
Schistosoma mansoni	cathepsin s	0.0027	0.0128	0.0177
Onchocerca volvulus		0.0079	0.1227	0.1227
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.1362	0.1587
Echinococcus multilocularis	mitogen activated protein kinase	0.0053	0.0682	0.0689
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0037	0.0334	0.042
Loa Loa (eye worm)	LGC-31 protein	0.0079	0.1227	0.1238
Leishmania major	cathepsin L-like protease	0.0086	0.1362	0.1587
Trypanosoma cruzi	cruzipain precursor, putative	0.0086	0.1362	0.1587
Trichomonas vaginalis	CMGC family protein kinase	0.0053	0.0682	0.3494
Onchocerca volvulus		0.0037	0.0334	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0334	0.0337
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0037	0.0334	0.0337
Echinococcus multilocularis	acetylcholinesterase	0.0074	0.1112	0.1123
Brugia malayi	mbt repeat family protein	0.0046	0.054	0.0679
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0804	0.0812
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0181	0.3345	0.4623
Brugia malayi	cathepsin L-like precursor	0.0059	0.0804	0.1011
Schistosoma mansoni	smad1 5 8 and	0.0025	0.0082	0.0114
Entamoeba histolytica	cysteine proteinase, putative	0.0086	0.1362	1
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0079	0.1227	0.1238
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0543	0.187
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.0355	0.0491
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0043	0.0462	0.0582
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0079	0.1227	0.1543
Trypanosoma brucei	cysteine peptidase C (CPC)	0.007	0.1024	0.1155
Echinococcus multilocularis	Dipeptidyl peptidase 9	0.0057	0.0751	0.0758
Echinococcus multilocularis	acetylcholinesterase	0.0074	0.1112	0.1123
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0217	0.4091	0.413
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0039	0.0377	0.0381
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0317	0.032
Leishmania major	hypothetical protein, conserved	0.0036	0.0317	0.0251
Echinococcus granulosus	histone acetyltransferase MYST2	0.0053	0.0674	0.068
Loa Loa (eye worm)	Smad1	0.0025	0.0082	0.0083
Onchocerca volvulus		0.0086	0.1362	0.1362
Onchocerca volvulus		0.0043	0.0462	0.0462
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0053	0.0682	0.0718
Schistosoma mansoni	cellular tumor antigen P53	0.0052	0.0649	0.0898
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0043	0.0462	0.0582
Trypanosoma cruzi	cruzipain precursor, putative	0.0027	0.0128	0.001
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0079	0.1227	0.1543
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0079	0.1227	0.1696
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0025	0.0082	0.0083
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0086	0.1362	0.1375
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0053	0.0682	0.0718
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.012	0.088
Brugia malayi	MH2 domain containing protein	0.036	0.7097	0.8928
Echinococcus granulosus	smad	0.0025	0.0082	0.0083
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.0543	0.187
Schistosoma mansoni	nAChR subunit	0.0079	0.1227	0.1696
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0079	0.1227	0.1238
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0037	0.0334	0.042
Plasmodium vivax	unspecified product	0.0027	0.0128	0.0938
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0053	0.0674	0.068
Brugia malayi	Carboxylesterase family protein	0.0074	0.1112	0.1399
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0804	0.0812
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0543	0.187
Schistosoma mansoni	sex comb on midleg homolog	0.0046	0.054	0.0746
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0053	0.0682	0.0718
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1227	0.1238
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0334	0.0337
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0037	0.0334	0.042
Toxoplasma gondii	dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein	0.0057	0.0751	0.5078
Brugia malayi	Papain family cysteine protease containing protein	0.0047	0.0543	0.0684
Trypanosoma brucei	protein kinase, putative	0.0053	0.0682	0.0718
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0334	0.0337
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0462	0.0467
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0334	0.0337
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	0.0057	0.0751	0.1038
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0039	0.0377	0.0576
Schistosoma mansoni	smad1 5 8 and	0.0025	0.0082	0.0114
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.1362	1
Echinococcus granulosus	cysteine protease	0.0047	0.0543	0.0549
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0037	0.0334	0.0462
Leishmania major	cysteine peptidase A (CPA)	0.0086	0.1362	0.1587
Onchocerca volvulus	Cathepsin F homolog	0.0086	0.1362	0.1362
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0079	0.1227	0.1238
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0037	0.0334	0.0337
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0053	0.0668	0.0674
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.007	0.1024	0.1416
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.1362	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0181	0.3345	0.4623
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0317	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0334	0.0337
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0128	0.0129
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0543	0.2169
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0086	0.1362	1
Brugia malayi	Cathepsin L-like precursor	0.0059	0.0804	0.1011
Onchocerca volvulus		0.0037	0.0334	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0377	0.038
Brugia malayi	hypothetical protein	0.0037	0.0334	0.042
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.1362	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.012	0.088
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1227	0.1238
Onchocerca volvulus		0.0079	0.1227	0.1227
Brugia malayi	Cathepsin L-like precursor	0.0086	0.1362	0.1714
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0804	0.1112
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0039	0.0377	0.0576
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0047	0.0543	0.0751
Loa Loa (eye worm)	hypothetical protein	0.0046	0.054	0.0545
Plasmodium vivax	vivapain-2	0.0086	0.1362	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0086	0.1362	0.1375
Onchocerca volvulus	Putative nachr subunit	0.0217	0.4091	0.4091
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0181	0.3345	0.4623
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0058	0.0775	0.0782
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0043	0.0462	0.0639
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0039	0.0377	0.0328
Echinococcus multilocularis	neuropeptide s receptor	0.0495	0.9907	1
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0079	0.1227	0.1543
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0317	0.032
Loa Loa (eye worm)	MH2 domain-containing protein	0.036	0.7097	0.7163
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.1362	0.1587
Echinococcus multilocularis	muscleblind protein	0.0156	0.2831	0.2858
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0543	0.2169
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0036	0.0317	0.032
Loa Loa (eye worm)	fibroinase	0.0086	0.1362	0.1375
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0079	0.1227	0.1238
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0037	0.0334	0.042
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.1362	1
Plasmodium vivax	vivapain-2	0.0086	0.1362	1
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0039	0.0377	0.0328
Echinococcus granulosus	cathepsin b	0.0181	0.3345	0.3376
Echinococcus granulosus	acetylcholinesterase	0.0074	0.1112	0.1123
Echinococcus multilocularis	muscleblind protein 1	0.0156	0.2831	0.2858
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0086	0.1362	1
Echinococcus multilocularis	nAChR subunit	0.0079	0.1227	0.1238
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0317	0.2324
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0039	0.0377	0.0381
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0401	0.795	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0472	0.0477
Loa Loa (eye worm)	hypothetical protein	0.0217	0.4091	0.4129
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0059	0.0804	0.0874
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1227	0.1238
Loa Loa (eye worm)	hypothetical protein	0.0086	0.1362	0.1375
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.1362	1
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0401	0.795	1
Brugia malayi	beta-lactamase family protein	0.0036	0.0317	0.0398
Echinococcus granulosus	cathepsin b	0.0181	0.3345	0.3376
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.1362	1
Loa Loa (eye worm)	mbt repeat family protein	0.0046	0.054	0.0545
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.0355	0.0358
Echinococcus granulosus	metabotropic glutamate receptor 2	0.0036	0.0317	0.032
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0086	0.1362	0.1375
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0804	0.1872
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0079	0.1227	0.1696
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0079	0.1227	0.1543
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0093	0.1511	0.1525
Trichomonas vaginalis	CMGC family protein kinase	0.0053	0.0682	0.3494
Plasmodium vivax	ataxin-2 like protein, putative	0.0026	0.012	0.088
Loa Loa (eye worm)	MH1 domain-containing protein	0.0025	0.0082	0.0083
Echinococcus multilocularis	cysteine protease	0.0086	0.1362	0.1375
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0086	0.1362	0.1375
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0086	0.1362	0.1375
Brugia malayi	excitatory GABA receptor EXP-1A	0.0079	0.1227	0.1543
Loa Loa (eye worm)	transcription factor SMAD2	0.036	0.7097	0.7163
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0079	0.1227	0.1696
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0462	0.0467
Brugia malayi	Cation transporter family protein	0.0079	0.1227	0.1543
Onchocerca volvulus		0.0086	0.1362	0.1362
Brugia malayi	prolyl oligopeptidase family protein	0.0057	0.0751	0.0944
Schistosoma mansoni	neurotransmitter gated ion channel	0.0037	0.0334	0.0462
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0039	0.0377	0.0217
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0039	0.0377	0.0381
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.1362	1
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	0.0168	0.3083	0.3112
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0053	0.0674	0.0848
Brugia malayi	Cation transporter family protein	0.0079	0.1227	0.1543
Brugia malayi	metabotropic glutamate receptor type 2	0.0021	0.0004	0.0005
Brugia malayi	Smad1	0.0025	0.0082	0.0104
Loa Loa (eye worm)	MBCTL1	0.0053	0.0674	0.068
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.1362	1
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0079	0.1227	0.1238
Toxoplasma gondii	ABC1 family protein	0.0036	0.0317	0.1584
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0317	0.032
Brugia malayi	Muscleblind-like protein	0.0156	0.2831	0.3561
Onchocerca volvulus	Cathepsin L homolog	0.0086	0.1362	0.1362
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0079	0.1227	0.1238
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0254	0.4884	0.4929
Brugia malayi	beta-lactamase family protein	0.0036	0.0317	0.0398
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0079	0.1227	0.1238
Brugia malayi	hypothetical protein	0.0037	0.0334	0.042
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.0401	0.795	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0027	0.0128	0.0161
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0079	0.1227	0.1238
Entamoeba histolytica	cysteine proteinase 2	0.0047	0.0543	0.187
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0128	0.0161
Echinococcus multilocularis	smad	0.0025	0.0082	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0156	0.2831	0.2858
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0059	0.0804	0.0812
Trypanosoma brucei	Dipeptidyl-peptidase 8-like, putative	0.0057	0.0751	0.0806
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.1362	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0086	0.1362	0.1587
Brugia malayi	hypothetical protein	0.0037	0.0334	0.042
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0053	0.0682	0.0718
Onchocerca volvulus		0.0079	0.1227	0.1227
Brugia malayi	Papain family cysteine protease containing protein	0.0047	0.0543	0.0684
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0037	0.0334	0.0337
Onchocerca volvulus		0.0036	0.0317	0.0317
Schistosoma mansoni	nAChR subunit	0.0079	0.1227	0.1696
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.0804	0.466
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0317	0.032
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0046	0.054	0.0545
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0079	0.1227	0.1543
Echinococcus multilocularis	cathepsin b	0.0181	0.3345	0.3376
Toxoplasma gondii	cathepsin CPL	0.0086	0.1362	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0093	0.1511	0.2088
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0334	0.0337
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	0.0168	0.3083	0.4262
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0317	0.032
Leishmania major	cathepsin L-like protease	0.0086	0.1362	0.1587
Onchocerca volvulus		0.0059	0.0804	0.0804
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0043	0.0462	0.0582
Plasmodium vivax	vivapain-3	0.0047	0.0543	0.3989
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1227	0.1238
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0543	0.187
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0079	0.1227	0.1238
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.1362	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.1362	1
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0079	0.1227	0.1238
Brugia malayi	beta-lactamase	0.0036	0.0317	0.0398
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1227	0.1238
Schistosoma mansoni	neurotransmitter gated ion channel	0.0037	0.0334	0.0462
Leishmania major	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	0.0057	0.0751	0.0806
Onchocerca volvulus		0.0079	0.1227	0.1227
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0217	0.4091	0.413
Echinococcus granulosus	cathepsin l1	0.0086	0.1362	0.1375
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1227	0.1238
Loa Loa (eye worm)	hypothetical protein	0.0026	0.012	0.0121
Brugia malayi	cathepsin B-like cysteine proteinase	0.0181	0.3345	0.4207
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	0.0168	0.3083	0.3083
Brugia malayi	Cathepsin L-like precursor	0.0059	0.0804	0.1011
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0079	0.1227	0.1238
Brugia malayi	Cathepsin L-like precursor	0.0086	0.1362	0.1714
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.1362	0.1587
Echinococcus granulosus	glycine receptor subunit beta	0.0079	0.1227	0.1238
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0334	0.0337
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0462	0.0467
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0079	0.1227	0.1543
Trypanosoma cruzi	dipeptidyl-peptidase 8-like serine peptidase	0.0057	0.0751	0.0806
Echinococcus multilocularis	cathepsin L	0.0047	0.0543	0.0549
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0086	0.1362	0.1375
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0317	0.032
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0128	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0462	0.0467
Mycobacterium tuberculosis	Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase)	0.0161	0.2922	0.6469
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0543	0.187
Brugia malayi	Papain family cysteine protease containing protein	0.0086	0.1362	0.1714
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.1362	1
Loa Loa (eye worm)	acetylcholine receptor protein	0.0037	0.0334	0.0337
Onchocerca volvulus		0.0079	0.1227	0.1227
Toxoplasma gondii	aldehyde dehydrogenase	0.0059	0.0804	0.5509
Onchocerca volvulus		0.0086	0.1362	0.1362
Brugia malayi	hypothetical protein	0.0037	0.0334	0.042
Trypanosoma cruzi	cysteine proteinase, putative	0.0047	0.0543	0.0541
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.1362	0.1587
Brugia malayi	Cathepsin L-like precursor	0.0086	0.1362	0.1714
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0462	0.0467
Schistosoma mansoni	metabotropic glutamate receptor	0.0021	0.0004	0.0006
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0804	0.1112
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0377	0.0576
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0317	0.0251
Loa Loa (eye worm)	acetylcholinesterase 1	0.0074	0.1112	0.1123
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0543	0.187
Echinococcus multilocularis	cysteine protease	0.0086	0.1362	0.1375
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0039	0.0377	0.0328
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0047	0.0543	0.3989
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0058	0.0775	0.0782
Brugia malayi	mbt repeat family protein	0.0046	0.054	0.0679
Echinococcus multilocularis	polycomb protein SCMH1	0.0046	0.054	0.0545
Brugia malayi	prolyl oligopeptidase family protein	0.0168	0.3083	0.3878
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0543	0.187
Schistosoma mansoni	sex comb on midleg homolog	0.0046	0.054	0.0746
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0229	0.4343	1
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0025	0.0082	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1227	0.1238
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0462	0.0467
Brugia malayi	Cathepsin L-like precursor	0.0086	0.1362	0.1714
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.0543	0.187
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0086	0.1362	1
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0079	0.1227	0.1238
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0334	0.0337
Leishmania major	cathepsin L-like protease	0.0086	0.1362	0.1587
Schistosoma mansoni	cathepsin F (C01 family)	0.0059	0.0804	0.1111
Entamoeba histolytica	cysteine protease, putative	0.0086	0.1362	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0086	0.1362	0.1883
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.0049	0.0584	0.0807
Schistosoma mansoni	family S28 unassigned peptidase (S28 family)	0.0367	0.7235	1
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0079	0.1227	0.1696
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0039	0.0377	0.0381
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0037	0.0334	0.042
Entamoeba histolytica	hypothetical protein	0.0043	0.0462	0.1065
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0543	0.187
Schistosoma mansoni	smad1 5 8 and	0.0025	0.0082	0.0114
Brugia malayi	hypothetical protein	0.0037	0.0334	0.042
Entamoeba histolytica	cysteine proteinase, putative	0.0059	0.0804	0.4457
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1227	0.1238
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0025	0.0082	0.0083
Schistosoma mansoni	lipoxygenase	0.0058	0.0775	0.1071
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0668	0.0674
Echinococcus multilocularis	cathepsin L cysteine protease	0.0086	0.1362	0.1375
Loa Loa (eye worm)	hypothetical protein	0.0181	0.3345	0.3376
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1227	0.1238
Loa Loa (eye worm)	glutamate receptor	0.0043	0.0462	0.0466
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0093	0.1511	0.2088
Loa Loa (eye worm)	GABA receptor subunit	0.0043	0.0462	0.0467
Loa Loa (eye worm)	cysteine protease	0.0086	0.1362	0.1375
Echinococcus granulosus	Dipeptidyl peptidase 9	0.0057	0.0751	0.0758
Trypanosoma cruzi	cysteine peptidase, putative	0.0047	0.0543	0.0541
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0317	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0317	0.032
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0079	0.1227	0.1543
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0543	0.187
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0079	0.1227	0.1238
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0317	0.0398
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0317	0.032
Trichomonas vaginalis	CMGC family protein kinase	0.0053	0.0682	0.3494
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.1362	1
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0046	0.054	0.0746
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0317	0.5
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0053	0.0674	0.068
Echinococcus granulosus	neuropeptide s receptor	0.0495	0.9907	1
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.0543	0.187
Echinococcus granulosus	cathepsin L	0.0047	0.0543	0.0549
Schistosoma mansoni	nAChR subunit	0.0037	0.0334	0.0462
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0334	0.0337
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0047	0.0543	0.0751
Onchocerca volvulus		0.0052	0.0649	0.0649
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0079	0.1227	0.1543
Schistosoma mansoni	metabotropic glutamate receptor	0.0036	0.0317	0.0438
Leishmania major	cathepsin L-like protease	0.0086	0.1362	0.1587
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1227	0.1238
Loa Loa (eye worm)	prolyl oligopeptidase	0.0168	0.3083	0.3112
Onchocerca volvulus		0.0079	0.1227	0.1227
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0462	0.0467
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.0355	0.0358
Echinococcus granulosus	cathepsin l1	0.0059	0.0804	0.0812
Mycobacterium ulcerans	epoxide hydrolase EphA	0.0161	0.2922	1
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0217	0.4091	0.413
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0093	0.1511	0.1525
Echinococcus multilocularis	nAChR subunit	0.0043	0.0462	0.0467
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.1362	1
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0043	0.0462	0.0639
Schistosoma mansoni	nAChR subunit	0.0079	0.1227	0.1696
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0217	0.4091	0.413
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0047	0.0543	0.0541
Onchocerca volvulus	Cathepsin L homolog	0.0086	0.1362	0.1362
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0217	0.4091	0.413
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0079	0.1227	0.1543
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0334	0.0337
Echinococcus granulosus	SAM and MBT domain containing protein	0.0046	0.054	0.0545
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.1362	0.1587
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1227	0.1238
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.1362	0.1587
Echinococcus granulosus	metabotropic glutamate receptor 5	0.0053	0.0668	0.0674
Echinococcus granulosus	mitogen activated protein kinase 3	0.0053	0.0682	0.0689
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0334	0.0337
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0086	0.1362	1
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0037	0.0334	0.0337
Loa Loa (eye worm)	hypothetical protein	0.0156	0.2831	0.2858
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0079	0.1227	0.1238
Schistosoma mansoni	smad	0.0025	0.0082	0.0114
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0187	0.3471	0.3504
Giardia lamblia	Cathepsin B precursor	0.007	0.1024	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0334	0.0337
Trypanosoma cruzi	serine peptidase, Clan SC, Family S9B	0.0057	0.0751	0.0806
Echinococcus multilocularis	ubiquitin specific protease 41	0.0039	0.0377	0.0381
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.1362	0.1587
Schistosoma mansoni	nAChR subunit	0.0079	0.1227	0.1696
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.0128	0.001
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0039	0.0377	0.0328
Loa Loa (eye worm)	carboxylesterase	0.0074	0.1112	0.1123
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.1362	1
Brugia malayi	hydrolase, alpha/beta fold family protein	0.025	0.4794	0.603
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0039	0.0377	0.0521
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1227	0.1238
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0079	0.1227	0.1543
Onchocerca volvulus		0.0086	0.1362	0.1362
Echinococcus multilocularis	Lysosomal Pro X carboxypeptidase	0.0367	0.7235	0.7303
Echinococcus multilocularis	tumor protein p63	0.0353	0.6948	0.7013
Brugia malayi	hypothetical protein	0.0038	0.0355	0.0447
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0053	0.0682	0.0718
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.007	0.1024	0.1155
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0187	0.3471	0.3504
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.1362	1
Schistosoma mansoni	nAChR subunit	0.0079	0.1227	0.1696
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0053	0.0682	0.0718
Brugia malayi	MH1 domain containing protein	0.0025	0.0082	0.0104
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0027	0.0128	0.0161
Loa Loa (eye worm)	hydrolase	0.0495	0.9908	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0086	0.1362	0.1587
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1112	0.1123
Onchocerca volvulus		0.0043	0.0462	0.0462

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.211 uM	Inhibition of human recombinant cathepsin-k using Z-Phe-Arg-AMC as substrate preincubated for 15 mins measured after 1 hr by QFRET assay	ChEMBL.	22984809
IC50 (binding)	> 10 uM	Inhibition of human recombinant cathepsin-L using Z-Phe-Arg-AMC as substrate preincubated for 15 mins measured after 1 hr by QFRET assay	ChEMBL.	22984809
IC50 (binding)	> 11.8 uM	Inhibition of human recombinant cathepsin-S using Z-Val-Val-Arg-AMC as substrate preincubated for 15 mins measured after 1 hr by QFRET assay	ChEMBL.	22984809
IC50 (binding)	= 24.9 uM	Inhibition of human recombinant cathepsin-B using Z-Arg-Arg-AMC as substrate preincubated for 15 mins measured after 1 hr by QFRET assay	ChEMBL.	22984809

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2171997

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1684197