Detailed information for compound 1694139

Basic information

Technical information
  • TDR Targets ID: 1694139
  • Name: azane; benzoic acid
  • MW: 139.152 | Formula: C7H9NO2
  • H donors: 2 H acceptors: 2 LogP: -1.56 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)c1ccccc1.N
  • InChi: 1S/C7H6O2.H3N/c8-7(9)6-4-2-1-3-5-6;/h1-5H,(H,8,9);1H3
  • InChiKey: VWSRWGFGAAKTQG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ammonia; benzoic acid
  • 09696_FLUKA
  • 183334_ALDRICH
  • AMMONIUM BENZOATE
  • Benzoic acid ammonium salt
  • NSC7918
  • azanium benzoate
  • 14374-89-1
  • 1863-63-4
  • AI3-07834
  • Ammonii benzoas
  • Ammonium benzoicum
  • Benzoic acid, ammonium salt
  • EINECS 217-468-9
  • HSDB 555
  • NSC 7918
  • Vulnoc AB

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Chlamydia trachomatis D-amino acid dehydrogenase 0.0016 0.0149 0.3113
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0185 0.1454
Toxoplasma gondii thioredoxin reductase 0.0095 0.1287 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0261 0.0955
Toxoplasma gondii NADPH-glutathione reductase 0.0033 0.039 0.3031
Mycobacterium ulcerans acetyl-CoA synthetase 0.0007 0.0016 0.0059
Schistosoma mansoni sodium/hydrogen exchanger 2 (nhe2) 0.01 0.1356 0.1356
Brugia malayi Common central domain of tyrosinase family protein 0.0093 0.1259 0.3178
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0185 0.0678
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0173 0.0634
Echinococcus multilocularis glycerol 3 phosphate dehydrogenase 0.0016 0.0149 0.0149
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0033 0.039 0.3031
Brugia malayi CXXC zinc finger family protein 0.0029 0.0334 0.0843
Trypanosoma brucei glycerol-3-phosphate dehydrogenase (FAD-dependent), mitochondrial 0.0016 0.0149 0.1161
Mycobacterium ulcerans ion antiporter, NhaP 0.0019 0.0189 0.0693
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0261 0.0955
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0007 0.0016 0.0125
Loa Loa (eye worm) glutamate receptor 0.0019 0.0193 0.0487
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0009 0.0041 0.0316
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0009 0.0041 0.0319
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0007 0.0016 0.0059
Entamoeba histolytica sodium/proton antiporter, putative 0.0019 0.0189 0.1376
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0007 0.0016 0.0048
Loa Loa (eye worm) hypothetical protein 0.0013 0.0096 0.0242
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0583 0.0583
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.001 0.0075
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1275 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0261 0.1944
Trypanosoma cruzi NADH dehydrogenase, putative 0.0009 0.0041 0.0316
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0041 0.0316
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0261 0.1944
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0588 0.4611
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0008 0.0029 0.0216
Trichomonas vaginalis apoptosis inducing factor, putative 0.0009 0.0041 0.0319
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.01 0.1356 0.1356
Loa Loa (eye worm) hypothetical protein 0.01 0.1356 0.3424
Schistosoma mansoni microtubule-associated protein tau 0.0697 1 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.001 0.0075
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0261 0.2028
Loa Loa (eye worm) NHE-3 0.01 0.1356 0.3424
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0185 0.1441
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.0264 0.0666
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0009 0.0041 0.0319
Leishmania major hypothetical protein, conserved 0.0009 0.0041 0.0316
Loa Loa (eye worm) programmed cell death 8 0.0009 0.0041 0.0103
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0261 0.0659
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0094 0.1275 0.3219
Brugia malayi serine/threonine-protein kinase plk-2 0.0094 0.1275 0.3219
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0802 0.0802
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0009 0.0041 0.0316
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0044 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.001 0.0075
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0009 0.0041 0.0319
Plasmodium vivax FAD-dependent glycerol-3-phosphate dehydrogenase, putative 0.0016 0.0149 0.1161
Loa Loa (eye worm) glutamate receptor 0.0049 0.0622 0.157
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0009 0.0041 0.012
Mycobacterium ulcerans D-amino acid oxidase Aao 0.0195 0.2733 1
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0025 0.0276 0.2032
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.039 0.3031
Entamoeba histolytica thioredoxin reductase, putative 0.0009 0.0041 0.0195
Schistosoma mansoni d-amino acid oxidase 0.0195 0.2733 0.2733
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1275 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0261 0.0725
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0019 0.0019
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0019 0.0189 0.0558
Mycobacterium tuberculosis Possible thiamine biosynthesis oxidoreductase ThiO 0.0016 0.0149 0.044
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0093 0.1259 0.3178
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0009 0.0041 0.0316
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0009 0.0041 0.0073
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0044 0.0112
Plasmodium vivax thioredoxin reductase, putative 0.0095 0.1287 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0009 0.0041 0.0319
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0009 0.0041 0.0316
Echinococcus multilocularis sodium:hydrogen exchanger 0.01 0.1356 0.1356
Echinococcus granulosus metabotropic glutamate receptor 2 0.0041 0.0507 0.0507
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.039 0.3031
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0009 0.0041 0.1042
Trypanosoma cruzi trypanothione reductase, putative 0.0033 0.039 0.3031
Toxoplasma gondii sodium/hydrogen exchanger 3 protein 0.0019 0.0189 0.1472
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1275 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0261 0.0955
Mycobacterium leprae probable conserved integral membrane transport protein 0.0019 0.0189 0.0513
Echinococcus granulosus sodium:hydrogen exchanger 7 0.0019 0.0189 0.0189
Mycobacterium ulcerans hypothetical protein 0.0009 0.0041 0.0149
Loa Loa (eye worm) hypothetical protein 0.0093 0.1259 0.3178
Plasmodium falciparum sodium/hydrogen exchanger, Na+, H+ antiporter 0.0019 0.0189 0.1472
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0009 0.0041 0.0316
Schistosoma mansoni sodium/hydrogen exchanger 0.01 0.1356 0.1356
Schistosoma mansoni tyrosinase precursor 0.0093 0.1259 0.1259
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0185 0.0468
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0009 0.0041 0.0041
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0007 0.0016 0.0059
Trypanosoma cruzi NADH dehydrogenase, putative 0.0009 0.0041 0.0316
Trypanosoma cruzi Na/H antiporter-like protein, putative 0.0019 0.0189 0.1472
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0093 0.1259 0.3178
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.1275 0.1275
Brugia malayi RE18450p 0.0016 0.0149 0.0377
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0009 0.0041 0.0073
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0261 0.1944
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.001 0.0075
Trypanosoma cruzi L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0016 0.0149 0.1161
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0261 0.0769
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0009 0.0041 0.0103
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0016 0.0041
Schistosoma mansoni disulfide oxidoreductase 0.0009 0.0041 0.0041
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0159 0.0469
Schistosoma mansoni ap endonuclease 0.0019 0.0185 0.0185
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0009 0.0041 0.0041
Brugia malayi glutamate synthase 0.0009 0.0041 0.0103
Entamoeba histolytica serine/threonine protein kinase, putative 0.0094 0.1275 1
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0009 0.0041 0.0103
Mycobacterium ulcerans D-amino acid oxidase Aao 0.0016 0.0149 0.0547
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0007 0.0016 0.0125
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.001 0.0075
Mycobacterium leprae PROBABLE D-AMINO ACID OXIDASE AAO 0.0195 0.2733 0.8044
Onchocerca volvulus 0.0009 0.0041 0.03
Mycobacterium ulcerans glycerol-3-phosphate dehydrogenase GlpD2 0.0016 0.0149 0.0547
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0033 0.039 0.3031
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0016 0.0048
Onchocerca volvulus 0.0019 0.0189 0.1396
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0185 0.1344
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.039 0.3031
Loa Loa (eye worm) ShTK domain-containing protein 0.0093 0.1259 0.3178
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0173 0.0511
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0009 0.0041 0.0316
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0866 0.6727
Leishmania major glycerol-3-phosphate dehydrogenase-like protein 0.0016 0.0149 0.1161
Leishmania major trypanothione reductase 0.0095 0.1287 1
Loa Loa (eye worm) ShTK domain-containing protein 0.0093 0.1259 0.3178
Trichomonas vaginalis glutamate synthase, putative 0.0009 0.0041 0.0319
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0185 0.1441
Loa Loa (eye worm) hypothetical protein 0.0024 0.0261 0.0659
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0216 0.3045 0.8971
Echinococcus granulosus CREB binding protein 0.0098 0.1337 0.1337
Trypanosoma brucei L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0016 0.0149 0.1161
Plasmodium vivax glutathione reductase, putative 0.0095 0.1287 1
Onchocerca volvulus 0.0093 0.1259 0.9283
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0033 0.039 0.1427
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0009 0.0041 0.1042
Trichomonas vaginalis helicase, putative 0.0007 0.001 0.0075
Giardia lamblia NADH oxidase lateral transfer candidate 0.0033 0.039 0.2875
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 0.01 0.1356 0.1356
Loa Loa (eye worm) hypothetical protein 0.0016 0.0149 0.0377
Mycobacterium ulcerans potassium/proton antiporter 0.0019 0.0189 0.0693
Echinococcus granulosus glycerol 3 phosphate dehydrogenase 0.0016 0.0149 0.0149
Echinococcus multilocularis sodium:hydrogen exchanger 7 0.0019 0.0189 0.0189
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0159 0.0469
Echinococcus granulosus thioredoxin glutathione reductase 0.0095 0.1287 0.1287
Brugia malayi Metabotropic glutamate receptor precursor. 0.0049 0.0622 0.157
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0009 0.0041 0.0319
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0016 0.0041
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0033 0.039 0.3031
Onchocerca volvulus 0.0024 0.0261 0.1924
Trypanosoma brucei trypanothione reductase 0.0095 0.1287 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0261 0.0955
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0033 0.039 0.3031
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0016 0.0127
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0009 0.0041 0.1042
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0009 0.0041 0.0319
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0185 0.1441
Trypanosoma cruzi L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0016 0.0149 0.1161
Onchocerca volvulus 0.0093 0.1259 0.9283
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.024 0.3394 1
Toxoplasma gondii Na+/H+ exchanger NHE3 0.0019 0.0189 0.1472
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0093 0.1259 0.3178
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0802 0.6231
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.001 0.0075
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0009 0.0041 0.0316
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0802 0.0802
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0009 0.0041 0.012
Brugia malayi Sodium/hydrogen exchanger 8 0.0019 0.0189 0.0478
Echinococcus granulosus sodium:hydrogen exchanger 0.01 0.1356 0.1356
Brugia malayi follicle stimulating hormone receptor 0.028 0.3962 1
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.0866 0.6745
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0016 0.0125
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0009 0.0041 0.012
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0185 0.0185
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0465 0.0465
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0007 0.0016 0.0125
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 0.01 0.1356 0.1356
Echinococcus granulosus glutamate synthase 0.0009 0.0041 0.0041
Mycobacterium leprae Probable cholesterol oxidase precursor ChoD (cholesterol-O2 oxidoreductase) 0.0016 0.0149 0.0394
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0009 0.0041 0.0319
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.001 0.0075
Mycobacterium ulcerans glycerol-3-phosphate dehydrogenase 0.0016 0.0149 0.0547
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0044 0.0555 0.1402
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0009 0.0041 0.0149
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0009 0.0041 0.0319
Mycobacterium tuberculosis Probable reductase 0.0216 0.3045 0.8971
Giardia lamblia Thioredoxin reductase 0.0009 0.0041 0.03
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0016 0.0041
Loa Loa (eye worm) sodium/hydrogen exchanger 3 family protein 0.01 0.1356 0.3424
Schistosoma mansoni hypothetical protein 0.0009 0.0041 0.0041
Brugia malayi ShTK domain containing protein 0.0093 0.1259 0.3178
Trypanosoma brucei polo-like protein kinase 0.0094 0.1275 0.9912
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0033 0.039 1
Brugia malayi cDNA sequence BC016226 0.0016 0.0149 0.0377
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0013 0.0096 0.0242
Echinococcus granulosus mitochondrial sodium:hydrogen exchanger 9B2 0.0019 0.0189 0.0189
Trypanosoma cruzi FAD dependent oxidoreductase, putative 0.0016 0.0149 0.1161
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.001 0.0075
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0033 0.039 0.3031
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0007 0.0016 0.0048
Giardia lamblia Kinase, PLK 0.0094 0.1275 0.9403
Leishmania major hypothetical protein, conserved 0.0009 0.0041 0.0316
Mycobacterium leprae Possible thiamine biosynthesis oxidoreductase ThiO 0.0016 0.0149 0.0394
Leishmania major acetyl-CoA synthetase, putative 0.0007 0.0016 0.0125
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0007 0.0016 0.0041
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 20 0.0016 0.0149 0.1161
Loa Loa (eye worm) hypothetical protein 0.0016 0.0149 0.0377
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0009 0.0041 0.0041
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0016 0.0125
Schistosoma mansoni ATP:guanidino kinase (Smc74) 0.0016 0.0149 0.0149
Onchocerca volvulus Sodium\/hydrogen exchanger homolog 0.01 0.1356 1
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0007 0.0016 0.0016
Schistosoma mansoni fad oxidoreductase 0.0016 0.0149 0.0149
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0019 0.0019
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0009 0.0041 0.0316
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0016 0.0041
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0802 0.6231
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.001 0.0075
Loa Loa (eye worm) oxidoreductase 0.0007 0.0016 0.0041
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0007 0.0016 0.0059
Echinococcus multilocularis glutamate synthase 0.0009 0.0041 0.0041
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0009 0.0041 0.0103
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0159 0.0469
Onchocerca volvulus 0.0007 0.0016 0.0119
Trypanosoma brucei NADH dehydrogenase 0.0009 0.0041 0.0316
Onchocerca volvulus Sodium\/hydrogen exchanger homolog 0.01 0.1356 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0016 0.0059
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0008 0.0029 0.0074
Mycobacterium ulcerans NADH dehydrogenase 0.0009 0.0041 0.0149
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0185 0.4754
Toxoplasma gondii exonuclease III APE 0.0019 0.0185 0.1441
Loa Loa (eye worm) hypothetical protein 0.0008 0.0037 0.0094
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.039 0.3031
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0009 0.0041 0.0195
Schistosoma mansoni metabotropic glutamate receptor 0.0024 0.0259 0.0259
Trypanosoma cruzi sodium/hydrogen exchanger, putative 0.0019 0.0189 0.1472
Mycobacterium tuberculosis Probable conserved integral membrane transport protein YjcE 0.0019 0.0189 0.0558
Schistosoma mansoni hypothetical protein 0.0008 0.0029 0.0029
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0016 0.0041
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.039 0.3031
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.024 0.3394 1
Schistosoma mansoni glutamate synthase 0.0009 0.0041 0.0041
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0009 0.0041 0.0319
Plasmodium falciparum ferrodoxin reductase-like protein 0.0009 0.0041 0.0316
Loa Loa (eye worm) hypothetical protein 0.01 0.1356 0.3424
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0009 0.0041 0.012
Loa Loa (eye worm) hypothetical protein 0.0195 0.2733 0.69
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0866 0.6727
Echinococcus multilocularis GPCR, family 3, C terminal 0.0008 0.0029 0.0029
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0033 0.039 0.039
Schistosoma mansoni cpg binding protein 0.0031 0.0358 0.0358
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.039 0.3031
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0802 0.0802
Schistosoma mansoni cpg binding protein 0.0031 0.0358 0.0358
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0016 0.0048
Brugia malayi glutathione reductase 0.0095 0.1287 0.3248
Brugia malayi Receptor family ligand binding region containing protein 0.0013 0.0096 0.0242
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.001 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.001 0.0075
Schistosoma mansoni hypothetical protein 0.0019 0.0189 0.0189
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0007 0.0016 0.0059
Loa Loa (eye worm) hypothetical protein 0.0018 0.0173 0.0437
Mycobacterium ulcerans glutamate synthase subunit beta 0.0009 0.0041 0.0149
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0261 0.2028
Trichomonas vaginalis mercuric reductase, putative 0.0033 0.039 0.3058
Loa Loa (eye worm) sodium/hydrogen exchanger 0.01 0.1356 0.3424
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0216 0.3045 0.8971
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0009 0.0041 0.0316
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0009 0.0041 0.0316
Schistosoma mansoni sodium/hydrogen exchanger 3 (nhe3) 0.0019 0.0189 0.0189
Leishmania major hypothetical protein, conserved 0.0019 0.0189 0.1472
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0009 0.0041 0.0316
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0009 0.0041 0.0041
Leishmania major acetyl-CoA synthetase, putative 0.0007 0.0016 0.0125
Plasmodium falciparum glutathione reductase 0.0033 0.039 0.3031
Loa Loa (eye worm) hypothetical protein 0.006 0.0786 0.1983
Toxoplasma gondii sodium/hydrogen exchanger NHE2 0.0019 0.0189 0.1472
Echinococcus multilocularis microtubule associated protein 2 0.0697 1 1
Echinococcus multilocularis mitochondrial sodium:hydrogen exchanger 9B2 0.0019 0.0189 0.0189
Wolbachia endosymbiont of Brugia malayi Kef-type K+ transport system, membrane component 0.0019 0.0189 0.4857
Mycobacterium ulcerans dehydrogenase 0.0009 0.0041 0.0149
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0007 0.0016 0.0048
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0583 0.0583
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0019 0.0019
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0261 0.0725
Echinococcus granulosus metabotropic glutamate receptor 5 0.006 0.0786 0.0786
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0009 0.0041 0.0195
Onchocerca volvulus Sodium\/hydrogen exchanger homolog 0.01 0.1356 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0033 0.039 0.1427
Schistosoma mansoni sulfide quinone reductase 0.0009 0.0041 0.0041
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0041 0.0316
Loa Loa (eye worm) tyrosinase 1 0.0093 0.1259 0.3178
Onchocerca volvulus 0.0093 0.1259 0.9283
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0583 0.0583
Brugia malayi sodium/hydrogen exchanger 3 family protein 0.0019 0.0189 0.0478
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0016 0.0125
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0007 0.0016 0.0048
Trichomonas vaginalis glutamate synthase, putative 0.0009 0.0041 0.0319
Leishmania major NADH dehydrogenase, putative 0.0009 0.0041 0.0316
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0802 0.0802
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0016 0.0059
Toxoplasma gondii Na+/H+ exchanger NHE1 0.0019 0.0189 0.1472
Schistosoma mansoni glycerol-3-phosphate dehydrogenase 0.0016 0.0149 0.0149
Toxoplasma gondii propionate-CoA ligase 0.0007 0.0016 0.0125
Onchocerca volvulus Dimethylglycine dehydrogenase, mitochondrial homolog 0.0016 0.0149 0.1101
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0009 0.0041 0.0316
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0056 0.0719 0.0719
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0016 0.0059
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0094 0.1275 0.1275
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0093 0.1259 0.3178
Brugia malayi hypothetical protein 0.0019 0.0189 0.0478
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0033 0.039 0.3031
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0216 0.3045 0.8971
Echinococcus granulosus CREB binding protein 0.0016 0.0148 0.0148
Trichomonas vaginalis glutathione reductase, putative 0.0033 0.039 0.3058
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0261 0.0769
Toxoplasma gondii hypothetical protein 0.0016 0.0149 0.1161
Onchocerca volvulus Poor gastrulation protein homolog 0.0008 0.0029 0.0216
Plasmodium vivax ferrodoxin reductase, putative 0.0009 0.0041 0.0316
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0009 0.0041 0.0149
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0185 0.1454
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.001 0.0075
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0009 0.0041 0.0103
Trypanosoma brucei glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0016 0.0149 0.1161
Schistosoma mansoni CREB-binding protein 2 0.0098 0.1337 0.1337
Schistosoma mansoni glutamate synthase 0.0009 0.0041 0.0041
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0007 0.0016 0.0048
Brugia malayi metabotropic glutamate receptor type 2 0.0024 0.0259 0.0654
Mycobacterium ulcerans membrane transporter 0.0019 0.0189 0.0693
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0009 0.0041 0.0195
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0185 0.1441
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0173 0.1347
Plasmodium vivax sodium/hydrogen exchanger 1, putative 0.0019 0.0189 0.1472
Onchocerca volvulus 0.0029 0.0334 0.2463
Echinococcus multilocularis CREB binding protein 0.0016 0.0148 0.0148
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0261 0.0955
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0261 0.0955
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0007 0.0016 0.0048
Loa Loa (eye worm) glutathione reductase 0.0095 0.1287 0.3248
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0007 0.0016 0.0016
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0802 0.2933
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0016 0.0059
Leishmania major hypothetical protein, conserved 0.0016 0.0149 0.1161
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0033 0.039 0.3031
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0009 0.0041 0.0316
Loa Loa (eye worm) hypothetical protein 0.0018 0.0173 0.0437
Onchocerca volvulus 0.0019 0.0189 0.1396
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0583 0.0583
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.001 0.0075
Leishmania major Na/H antiporter-like protein 0.0019 0.0189 0.1472
Mycobacterium ulcerans ferredoxin reductase 0.0009 0.0041 0.0149
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0016 0.0125
Schistosoma mansoni ap endonuclease 0.0019 0.0185 0.0185
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.039 0.3031
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0016 0.0059
Echinococcus granulosus CREB binding protein 0.0016 0.0148 0.0148
Schistosoma mansoni metabotropic glutamate receptor 0.0041 0.0507 0.0507
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0159 0.0469
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0009 0.0041 0.0149
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0033 0.039 1
Schistosoma mansoni fad oxidoreductase 0.0016 0.0149 0.0149
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0185 0.0546
Brugia malayi sodium/hydrogen exchanger 3 family protein 0.01 0.1356 0.3424
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1275 1
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0016 0.0149 0.1161
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0033 0.039 0.1149
Echinococcus granulosus sodium:hydrogen exchanger 0.01 0.1356 0.1356
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0016 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.001 0.0075
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.0866 0.0866
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0261 0.0955
Entamoeba histolytica anaerobic glycerol-3-phosphate dehydrogenase subunit A, putative 0.0016 0.0149 0.1058
Mycobacterium tuberculosis Probable oxidoreductase 0.024 0.3394 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.039 0.3031
Entamoeba histolytica disulphide oxidoreductase, putative 0.0009 0.0041 0.0195
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.039 0.3031
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0007 0.0016 0.0059
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0009 0.0041 0.0316
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0009 0.0041 0.0073
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0016 0.0041
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.039 0.3031
Echinococcus multilocularis CREB binding protein 0.0067 0.089 0.089
Brugia malayi TAZ zinc finger family protein 0.0098 0.1337 0.3376
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0033 0.039 0.039
Onchocerca volvulus Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial homolog 0.0016 0.0149 0.1101
Schistosoma mansoni tyrosinase precursor 0.0093 0.1259 0.1259
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0043 0.0108
Loa Loa (eye worm) hypothetical protein 0.0019 0.0189 0.0478
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0009 0.0041 0.0149
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1275 1
Echinococcus multilocularis FAD dependent oxidoreductase domain containing protein 0.0016 0.0149 0.0149
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0009 0.0041 0.0195
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0009 0.0041 0.0041
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0009 0.0041 0.0149
Trypanosoma brucei electron transfer flavoprotein-ubiquinone oxidoreductase, putative 0.0016 0.0149 0.1161
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1275 1
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0009 0.0041 0.0073
Entamoeba histolytica sodium/proton antiporter, putative 0.0019 0.0189 0.1376
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0185 0.0468
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0016 0.0059
Echinococcus granulosus GPCR family 3 C terminal 0.0008 0.0029 0.0029
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0216 0.3045 0.8966
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0094 0.1275 0.9912
Loa Loa (eye worm) hypothetical protein 0.0016 0.0149 0.0377
Loa Loa (eye worm) hypothetical protein 0.0019 0.0189 0.0478
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.0866 0.2185
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0866 0.6727
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0009 0.0041 0.0316
Loa Loa (eye worm) glycerol-3-phosphate dehydrogenase 0.0016 0.0149 0.0377
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.0081 0.1081 0.1081
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0094 0.1275 0.1275
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0009 0.0041 0.0316
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.024 0.3394 1
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0009 0.0041 0.0149
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.001 0.0075
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0009 0.0041 0.012
Echinococcus multilocularis metabotropic glutamate receptor 5 0.006 0.0786 0.0786
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0185 0.1367
Onchocerca volvulus 0.0007 0.0016 0.0119
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0583 0.1471
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0016 0.0149 0.1161
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0802 0.2933
Loa Loa (eye worm) follicle stimulating hormone receptor 0.028 0.3962 1
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0261 0.0659
Loa Loa (eye worm) hypothetical protein 0.0024 0.0261 0.0659
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0019 0.0019
Onchocerca volvulus 0.0093 0.1259 0.9283
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0465 0.0465
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0583 0.0583
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0009 0.0041 0.0041
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0007 0.0016 0.0048
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0007 0.0016 0.0059
Leishmania major hypothetical protein, conserved 0.0016 0.0149 0.1161
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.0866 0.6727
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0009 0.0041 0.012
Plasmodium falciparum thioredoxin reductase 0.0033 0.039 0.3031
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.01 0.1356 0.1356
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0095 0.1287 0.3791
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0007 0.0016 0.0059
Mycobacterium ulcerans thiamine biosynthesis oxidoreductase ThiO 0.0016 0.0149 0.0547
Loa Loa (eye worm) hypothetical protein 0.0007 0.0016 0.0041
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.0866 0.2185
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0007 0.0016 0.0059
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.0866 0.0866
Loa Loa (eye worm) hypothetical protein 0.0093 0.1259 0.3178
Schistosoma mansoni sulfide quinone reductase 0.0009 0.0041 0.0041
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0261 0.0659
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1275 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0185 0.4144
Trypanosoma cruzi trypanothione reductase, putative 0.0095 0.1287 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.1275 0.9912
Onchocerca volvulus Putative fad oxidoreductase 0.0016 0.0149 0.1101
Schistosoma mansoni cpg binding protein 0.0029 0.0334 0.0334
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0009 0.0041 0.0041
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0019 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.001 0.0075
Brugia malayi pyruvate dehydrogenase phosphatase regulatory subunit precursor 0.0016 0.0149 0.0377
Loa Loa (eye worm) sodium-hydrogen exchanger NHE1 0.0019 0.0189 0.0478
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0009 0.0041 0.0041
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.1275 0.9912
Schistosoma mansoni glutamate synthase 0.0009 0.0041 0.0041
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.01 0.1356 0.1356
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0216 0.3045 0.8971
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.0866 0.0866
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0033 0.039 0.0984
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0588 0.4611
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 0.01 0.1356 0.1356
Schistosoma mansoni hypothetical protein 0.0019 0.0189 0.0189
Onchocerca volvulus Serine\/threonine kinase homolog 0.0094 0.1275 0.9403
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.0264 0.0666
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0016 0.0048
Loa Loa (eye worm) thioredoxin reductase 0.0095 0.1287 0.3248
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0009 0.0041 0.0041
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0185 0.0185
Echinococcus multilocularis CREB binding protein 0.0016 0.0148 0.0148
Loa Loa (eye worm) CBP-B 0.0068 0.0903 0.2279
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0016 0.0041
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0098 0.1337 0.1337
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0016 0.0125
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0802 0.2933
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0802 0.2362
Brugia malayi dimethylglycine dehydrogenase, mitochondrial precursor, putative 0.0016 0.0149 0.0377
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0033 0.039 0.039
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0009 0.0041 0.0041
Trypanosoma cruzi sodium/hydrogen exchanger, putative 0.0019 0.0189 0.1472
Trypanosoma brucei hypothetical protein, conserved 0.0009 0.0041 0.0316
Plasmodium falciparum FAD-dependent glycerol-3-phosphate dehydrogenase, putative 0.0016 0.0149 0.1161
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0805 0.0805
Toxoplasma gondii FAD-dependent glycerol-3-phosphate dehydrogenase 0.0016 0.0149 0.1161
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0261 0.2028
Mycobacterium tuberculosis Probable D-amino acid oxidase Aao 0.0179 0.2498 0.7361
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0009 0.0041 0.0316
Echinococcus granulosus sodium:hydrogen exchanger 2 (nhe2) 0.0081 0.1081 0.1081
Mycobacterium ulcerans hypothetical protein 0.0024 0.0261 0.0955
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase, putative 0.0016 0.0149 0.1161
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0016 0.0127
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0173 0.1347
Loa Loa (eye worm) hypothetical protein 0.01 0.1356 0.3424
Echinococcus multilocularis CREB binding protein 0.0016 0.0148 0.0148
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0009 0.0041 0.0041
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0016 0.0059
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0016 0.0048
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0009 0.0041 0.0149
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0009 0.0041 0.0316
Loa Loa (eye worm) hypothetical protein 0.0018 0.0173 0.0437
Schistosoma mansoni NAD dehydrogenase 0.0016 0.0149 0.0149
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.039 0.3031
Schistosoma mansoni Slc9a7 protein 0.0019 0.0189 0.0189
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0173 0.3798
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0009 0.0041 0.0316
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0735 0.5708
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0185 0.1441
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0583 0.1471
Loa Loa (eye worm) hypothetical protein 0.0024 0.0261 0.0659
Toxoplasma gondii selenide, water dikinase 0.0009 0.0041 0.0316
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0583 0.0583
Brugia malayi Thioredoxin reductase 0.0095 0.1287 0.3248
Echinococcus granulosus FAD dependent oxidoreductase domain containing protein 0.0016 0.0149 0.0149
Echinococcus multilocularis thioredoxin glutathione reductase 0.0095 0.1287 0.1287
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0013 0.0096 0.0242
Onchocerca volvulus 0.0007 0.0016 0.0119
Echinococcus multilocularis cpg binding protein 0.0031 0.0358 0.0358
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0334 0.0843
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.039 0.3031
Leishmania major hypothetical protein, conserved 0.0009 0.0041 0.0316
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0033 0.039 0.3031
Trypanosoma cruzi Na/H antiporter-like protein, putative 0.0019 0.0189 0.1472
Giardia lamblia Glutamate synthase 0.0009 0.0041 0.03
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0007 0.0016 0.0125
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0025 0.0276 0.206
Trypanosoma brucei FAD dependent oxidoreductase, putative 0.0016 0.0149 0.1161
Loa Loa (eye worm) hypothetical protein 0.0018 0.0173 0.0437
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.001 0.0075
Echinococcus granulosus cpg binding protein 0.0031 0.0358 0.0358
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0103
Mycobacterium ulcerans monoxygenase 0.0009 0.0041 0.0149
Echinococcus granulosus CREB binding protein 0.0061 0.0792 0.0792
Giardia lamblia Sodium/hydrogen exchanger 3 0.01 0.1356 1
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0016 0.0125
Loa Loa (eye worm) hypothetical protein 0.0018 0.0173 0.0437
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0009 0.0041 0.0316
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0009 0.0041 0.0041
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0009 0.0041 0.0319
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0041 0.0507 0.0507
Schistosoma mansoni acetyl-CoA synthetase 0.0007 0.0016 0.0016
Plasmodium falciparum thioredoxin reductase 0.0095 0.1287 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0582 0.147
Loa Loa (eye worm) hypothetical protein 0.0008 0.0029 0.0074
Onchocerca volvulus 0.0007 0.0016 0.0119
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0185 0.1441
Echinococcus multilocularis sodium:hydrogen exchanger 0.01 0.1356 0.1356
Treponema pallidum NADH oxidase 0.0033 0.039 1
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0006 0.0002 0.0006
Mycobacterium tuberculosis Probable dehydrogenase 0.0216 0.3045 0.8971
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0033 0.039 1
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0033 0.039 0.1427
Plasmodium vivax acetyl-CoA synthetase, putative 0.0007 0.0016 0.0125
Plasmodium falciparum glutathione reductase 0.0095 0.1287 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0016 0.0041
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0044 0.0044
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0583 0.0583
Schistosoma mansoni kinase 0.0048 0.0606 0.0606
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0033 0.039 0.3031

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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