Detailed information for compound 1698096

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 550.965 | Formula: C24H23ClN2O9S
  • H donors: 4 H acceptors: 9 LogP: 0.74 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)[C@@H]1O[C@@H](OCc2ccc(cn2)c2ncc(cc2c2ccc(cc2)S(=O)(=O)C)Cl)[C@H]([C@H]([C@@H]1O)O)O
  • InChi: 1S/C24H23ClN2O9S/c1-37(33,34)16-6-3-12(4-7-16)17-8-14(25)10-27-18(17)13-2-5-15(26-9-13)11-35-24-21(30)19(28)20(29)22(36-24)23(31)32/h2-10,19-22,24,28-30H,11H2,1H3,(H,31,32)/t19-,20-,21-,22+,24+/m0/s1
  • InChiKey: UJWKCNOGFMSHNK-VZGLXOSZSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni integrin alpha-ps 0.0046 0.0053 0.0053
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0484 0.094 1
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.0173 0.0173
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0242 0.0451 0.0449
Onchocerca volvulus 0.0091 0.0144 0.0342
Loa Loa (eye worm) hypothetical protein 0.0242 0.0451 0.0451
Schistosoma mansoni alpha glucosidase 0.0035 0.003 0.003
Brugia malayi hypothetical protein 0.0242 0.0451 0.0487
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.003 0.0003
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0242 0.0451 0.0449
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.031 0.0588 0.0588
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.003 0.0003
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.0172 0.8568
Echinococcus multilocularis geminin 0.0164 0.0293 0.0291
Schistosoma mansoni integrin alpha 0.0198 0.0361 0.0361
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.1254 0.2503 0.2501
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.0172 0.3728
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0526 0.1025 0.1124
Loa Loa (eye worm) hypothetical protein 0.0242 0.0451 0.0451
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0594 0.1164 0.1164
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.003 0.0141
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.4468 0.9019 0.9019
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0484 0.094 1
Entamoeba histolytica hypothetical protein 0.0035 0.003 0.0252
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.031 0.0588 0.0572
Brugia malayi Integrin alpha pat-2 precursor 0.0198 0.0361 0.0387
Brugia malayi excitatory GABA receptor EXP-1A 0.0526 0.1025 0.1124
Loa Loa (eye worm) hypothetical protein 0.0283 0.0533 0.0533
Echinococcus multilocularis nAChR subunit 0.0526 0.1025 0.1023
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.003 0.003
Trypanosoma cruzi hypothetical protein, conserved 0.0484 0.094 1
Loa Loa (eye worm) serotonin transporter b 0.1826 0.3662 0.3662
Loa Loa (eye worm) hypothetical protein 0.0352 0.0673 0.0673
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0484 0.094 1
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.0173 0.0173
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0173 0.1691
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0484 0.094 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.4952 1 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.003 0.0141
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.003 0.0028
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.4468 0.9019 0.9019
Schistosoma mansoni nAChR subunit 0.0526 0.1025 0.1025
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0242 0.0451 0.0451
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0484 0.094 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0079 0.3415
Loa Loa (eye worm) hypothetical protein 0.0526 0.1025 0.1025
Onchocerca volvulus 0.0526 0.1025 0.2761
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.0173 0.0173
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.031 0.0588 0.0588
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0484 0.094 1
Schistosoma mansoni nAChR subunit 0.0526 0.1025 0.1025
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.0195 0.4351
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0484 0.094 0.0939
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0081 0.0079
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.4952 1 1
Loa Loa (eye worm) ACC-1 protein 0.0526 0.1025 0.1025
Loa Loa (eye worm) hypothetical protein 0.0242 0.0451 0.0451
Schistosoma mansoni cpg binding protein 0.0037 0.0034 0.0034
Brugia malayi 6-phosphofructokinase 0.0105 0.0173 0.0179
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0484 0.094 1
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0242 0.0451 0.0451
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.4952 1 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0526 0.1025 0.1124
Echinococcus granulosus sodium and chloride dependent glycine 0.031 0.0588 0.0586
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0105 0.0173 0.0428
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0079 0.0062
Loa Loa (eye worm) hypothetical protein 0.031 0.0588 0.0588
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0079 0.0079
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0484 0.094 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0484 0.094 1
Brugia malayi Pre-SET motif family protein 0.0203 0.037 0.0398
Onchocerca volvulus 0.0594 0.1164 0.3143
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.003 0.0003
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.031 0.0588 0.0639
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0484 0.094 1
Toxoplasma gondii ABC1 family protein 0.0035 0.003 0.0013
Plasmodium vivax hypothetical protein, conserved 0.031 0.0588 0.6182
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0526 0.1025 0.1023
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0526 0.1025 0.1025
Echinococcus multilocularis sodium and chloride dependent glycine 0.031 0.0588 0.0586
Echinococcus multilocularis integrin alpha ps 0.0089 0.0139 0.0138
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.0195 1
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.031 0.0588 0.0588
Brugia malayi Bromodomain containing protein 0.0075 0.0111 0.0109
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.003
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0484 0.094 1
Onchocerca volvulus 0.0035 0.003 0.0028
Plasmodium vivax glutathione reductase, putative 0.0046 0.0052 0.0382
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.003 0.0141
Onchocerca volvulus 0.0035 0.003 0.0028
Brugia malayi hypothetical protein 0.0242 0.0451 0.0487
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0484 0.094 1
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0079 0.0079
Loa Loa (eye worm) beta-lactamase 0.0035 0.003 0.003
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0484 0.094 1
Echinococcus multilocularis serotonin transporter 0.1826 0.3662 0.3661
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.003 0.0013
Brugia malayi Cation transporter family protein 0.0526 0.1025 0.1124
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0484 0.094 0.094
Loa Loa (eye worm) hypothetical protein 0.0033 0.0026 0.0026
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0526 0.1025 0.1124
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0484 0.094 1
Loa Loa (eye worm) hypothetical protein 0.0283 0.0533 0.0533
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.031 0.0588 0.0572
Loa Loa (eye worm) hypothetical protein 0.0242 0.0451 0.0451
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.031 0.0588 0.0588
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0484 0.094 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0484 0.094 0.0925
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0526 0.1025 0.1025
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0052 0.0382
Loa Loa (eye worm) hypothetical protein 0.0069 0.0099 0.0099
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0484 0.094 0.0925
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.003 0.002
Brugia malayi glutathione reductase 0.0046 0.0052 0.0045
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0008 0.0008
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.003 0.0028
Loa Loa (eye worm) hypothetical protein 0.0526 0.1025 0.1025
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0079 0.1288
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0484 0.094 0.0925
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0173 0.3023
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.037 0.037
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.003 0.003
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0094 0.0077
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0484 0.094 0.0925
Echinococcus multilocularis lysosomal alpha glucosidase 0.0157 0.0279 0.0277
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0526 0.1025 0.1124
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0057 0.0057
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0484 0.094 0.0939
Entamoeba histolytica hypothetical protein 0.0035 0.003 0.0252
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0526 0.1025 0.1023
Loa Loa (eye worm) hypothetical protein 0.1826 0.3662 0.3662
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0526 0.1025 0.1124
Echinococcus multilocularis lysosomal alpha glucosidase 0.0157 0.0279 0.0277
Leishmania major trypanothione reductase 0.0046 0.0052 0.0247
Echinococcus granulosus glycine receptor subunit alpha 1 0.0526 0.1025 0.1023
Schistosoma mansoni integrin alpha-ps 0.0089 0.0139 0.0139
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0526 0.1025 0.1025
Loa Loa (eye worm) hypothetical protein 0.0242 0.0451 0.0451
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.003 0.0138
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0484 0.094 1
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0484 0.094 1
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.031 0.0588 0.0586
Loa Loa (eye worm) PDE1B protein 0.0484 0.094 0.094
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.031 0.0588 0.0588
Onchocerca volvulus 0.0033 0.0027 0.0019
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0484 0.094 0.094
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0484 0.094 0.0939
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0484 0.094 0.0925
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.1254 0.2503 0.2503
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0242 0.0451 0.0449
Brugia malayi beta-lactamase family protein 0.0035 0.003 0.002
Brugia malayi hypothetical protein 0.0242 0.0451 0.0487
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0594 0.1164 0.1164
Loa Loa (eye worm) hypothetical protein 0.0526 0.1025 0.1025
Brugia malayi beta-lactamase family protein 0.0035 0.003 0.002
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0484 0.094 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0053 0.0053
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.003 0.003
Loa Loa (eye worm) cytochrome P450 family protein 0.0051 0.0062 0.0062
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.041 1
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0484 0.094 0.0939
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0484 0.094 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.003
Loa Loa (eye worm) integrin alpha pat-2 0.0198 0.0361 0.0361
Loa Loa (eye worm) hypothetical protein 0.0242 0.0451 0.0451
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.003 0.0141
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0242 0.0451 0.0487
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0484 0.094 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0053 0.0053
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0283 0.0533 0.0579
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0484 0.094 1
Brugia malayi Cation transporter family protein 0.0526 0.1025 0.1124
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0157 0.0279 0.0279
Brugia malayi beta-lactamase 0.0035 0.003 0.002
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.003 0.0141
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0242 0.0451 0.0487
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0484 0.094 1
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0526 0.1025 0.1023
Schistosoma mansoni neurotransmitter gated ion channel 0.0242 0.0451 0.0451
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0526 0.1025 0.1025
Echinococcus multilocularis 6 phosphofructokinase 0.0105 0.0173 0.0172
Trypanosoma cruzi hypothetical protein, conserved 0.0484 0.094 1
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0242 0.0451 0.0449
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.003
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.003 0.003
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0484 0.094 0.0939
Loa Loa (eye worm) hypothetical protein 0.0526 0.1025 0.1025
Echinococcus granulosus nAChR subunit 0.0526 0.1025 0.1023
Schistosoma mansoni hypothetical protein 0.0035 0.003 0.003
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0484 0.094 0.094
Echinococcus granulosus sodium and chloride dependent glycine 0.031 0.0588 0.0586
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0173 0.3023
Loa Loa (eye worm) hypothetical protein 0.0526 0.1025 0.1025
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.003 0.0141
Plasmodium falciparum amino acid transporter, putative 0.031 0.0588 0.6182
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0052 0.0051
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0242 0.0451 0.0487
Loa Loa (eye worm) hypothetical protein 0.0526 0.1025 0.1025
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0484 0.094 1
Loa Loa (eye worm) hypothetical protein 0.031 0.0588 0.0588
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0105 0.0173 0.8667
Trichomonas vaginalis conserved hypothetical protein 0.0484 0.094 1
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0105 0.0173 0.3772
Echinococcus multilocularis integrin alpha 3 0.0152 0.0267 0.0265
Schistosoma mansoni nAChR subunit 0.0242 0.0451 0.0451
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0526 0.1025 0.1023
Schistosoma mansoni alpha-glucosidase 0.0135 0.0234 0.0234
Echinococcus multilocularis glycine receptor subunit beta 0.0526 0.1025 0.1023
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0526 0.1025 0.1124
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0484 0.094 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0484 0.094 1
Entamoeba histolytica hypothetical protein 0.0283 0.0533 1
Onchocerca volvulus 0.0526 0.1025 0.2761
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0484 0.094 0.1031
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0484 0.094 1
Schistosoma mansoni hypothetical protein 0.0033 0.0026 0.0026
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0484 0.094 0.0939
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.003 0.0028
Loa Loa (eye worm) ACC-1 protein 0.0526 0.1025 0.1025
Loa Loa (eye worm) hypothetical protein 0.0526 0.1025 0.1025
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0484 0.094 0.0925
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0484 0.094 1
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.003 0.0028
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0283 0.0533 0.0533
Loa Loa (eye worm) hypothetical protein 0.0594 0.1164 0.1164
Schistosoma mansoni sodium/chloride dependent transporter 0.031 0.0588 0.0588
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0173 0.3023
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.4952 1 1
Schistosoma mansoni nAChR subunit 0.0242 0.0451 0.0451
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.0173 0.1574
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0052 0.0051
Loa Loa (eye worm) hypothetical protein 0.0048 0.0057 0.0057
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0484 0.094 0.1031
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0484 0.094 0.0925
Giardia lamblia hypothetical protein 0.0484 0.094 0.0925
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0526 0.1025 0.1023
Schistosoma mansoni acetylcholine receptor subunit beta 0.0242 0.0451 0.0451
Onchocerca volvulus 0.0242 0.0451 0.1184
Schistosoma mansoni hypothetical protein 0.0164 0.0293 0.0293
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.4468 0.9019 0.9019
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0484 0.094 0.0925
Loa Loa (eye worm) hypothetical protein 0.0043 0.0046 0.0046
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0484 0.094 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0079 0.3415
Onchocerca volvulus Putative nachr subunit 0.1254 0.2503 0.6818
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.1254 0.2503 0.2765
Loa Loa (eye worm) hypothetical protein 0.0526 0.1025 0.1025
Loa Loa (eye worm) hypothetical protein 0.0242 0.0451 0.0451
Schistosoma mansoni nAChR subunit 0.0526 0.1025 0.1025
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0283 0.0533 0.0579
Brugia malayi phosphofructokinase 0.0105 0.0173 0.0179
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0484 0.094 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0484 0.094 1
Echinococcus multilocularis integrin alpha ps 0.0089 0.0139 0.0138
Loa Loa (eye worm) hypothetical protein 0.0242 0.0451 0.0451
Entamoeba histolytica hypothetical protein 0.0035 0.003 0.0252
Brugia malayi Sodium:neurotransmitter symporter family protein 0.1826 0.3662 0.4052
Entamoeba histolytica hypothetical protein 0.0035 0.003 0.0252
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0484 0.094 1
Brugia malayi CXXC zinc finger family protein 0.0033 0.0027 0.0016
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0484 0.094 0.094
Echinococcus granulosus glycine receptor subunit beta 0.0526 0.1025 0.1023
Echinococcus multilocularis sodium and chloride dependent glycine 0.031 0.0588 0.0586
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0484 0.094 1
Trichomonas vaginalis conserved hypothetical protein 0.0484 0.094 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0046 0.0053 0.0051
Echinococcus granulosus geminin 0.0164 0.0293 0.0291
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0484 0.094 0.094
Schistosoma mansoni sodium-dependent amino acid transporter 0.031 0.0588 0.0588
Loa Loa (eye worm) hypothetical protein 0.0242 0.0451 0.0451
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0043 0.0046 0.0037
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0526 0.1025 0.1025
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.003 0.0028
Onchocerca volvulus 0.031 0.0588 0.156
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.0173 0.1574
Leishmania major hypothetical protein, conserved 0.0484 0.094 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0242 0.0451 0.0487
Schistosoma mansoni nAChR subunit 0.0526 0.1025 0.1025
Loa Loa (eye worm) hypothetical protein 0.031 0.0588 0.0588
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0526 0.1025 0.1124
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0526 0.1025 0.1124
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0057 0.005
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0484 0.094 0.094
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0484 0.094 0.094
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0526 0.1025 0.1124
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0484 0.094 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0484 0.094 0.0925
Loa Loa (eye worm) GABA receptor subunit 0.0283 0.0533 0.0533
Loa Loa (eye worm) hypothetical protein 0.0242 0.0451 0.0451
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0484 0.094 1
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0484 0.094 0.0939
Plasmodium falciparum thioredoxin reductase 0.0046 0.0052 0.0382
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0484 0.094 0.094
Leishmania major cAMP-specific phosphodiesterase, putative 0.0484 0.094 1
Schistosoma mansoni sodium/chloride dependent transporter 0.1826 0.3662 0.3662
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0484 0.094 0.0925
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.0195 0.4351
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0242 0.0451 0.0487
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0008 0.0006
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.031 0.0588 0.0588
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.003 0.0253
Plasmodium falciparum transporter, putative 0.031 0.0588 0.6182
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0526 0.1025 0.1124
Loa Loa (eye worm) hypothetical protein 0.0046 0.0053 0.0053
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0484 0.094 1
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0484 0.094 1
Brugia malayi hypothetical protein 0.0242 0.0451 0.0487
Brugia malayi hypothetical protein 0.031 0.0588 0.0639
Loa Loa (eye worm) hypothetical protein 0.0526 0.1025 0.1025
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0484 0.094 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0484 0.094 1
Trypanosoma cruzi hypothetical protein, conserved 0.0484 0.094 1
Loa Loa (eye worm) hypothetical protein 0.0594 0.1164 0.1164
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0484 0.094 0.1031
Echinococcus granulosus glycine receptor subunit alpha 1 0.0526 0.1025 0.1023
Loa Loa (eye worm) hypothetical protein 0.0242 0.0451 0.0451
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.003 0.0141
Onchocerca volvulus 0.0242 0.0451 0.1184
Onchocerca volvulus 0.031 0.0588 0.156
Brugia malayi Cation transporter family protein 0.0594 0.1164 0.1279
Treponema pallidum sodium- and chloride- dependent transporter 0.1826 0.3662 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0057 0.005
Brugia malayi Sodium:neurotransmitter symporter family protein 0.031 0.0588 0.0639
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.0172 0.3728
Loa Loa (eye worm) hypothetical protein 0.4952 1 1
Schistosoma mansoni sodium/chloride dependent transporter 0.031 0.0588 0.0588
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0242 0.0451 0.0451
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.0195 0.4351
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0283 0.0533 0.0579
Toxoplasma gondii hypothetical protein 0.031 0.0588 0.0572
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0242 0.0451 0.0487
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0026 0.0016
Loa Loa (eye worm) hypothetical protein 0.0037 0.0035 0.0035
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0283 0.0533 0.0533
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.1254 0.2503 0.2501
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0484 0.094 1
Loa Loa (eye worm) hypothetical protein 0.031 0.0588 0.0588
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0283 0.0533 0.0579
Loa Loa (eye worm) hypothetical protein 0.0043 0.0046 0.0046
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.003 0.0253
Schistosoma mansoni bromodomain containing protein 0.0063 0.0088 0.0088
Schistosoma mansoni hypothetical protein 0.0164 0.0293 0.0293
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0016 0.0014
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.031 0.0588 0.0588
Schistosoma mansoni nAChR subunit 0.0526 0.1025 0.1025
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0484 0.094 0.1031
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0484 0.094 1
Loa Loa (eye worm) norepinephrine transporter 0.1826 0.3662 0.3662
Onchocerca volvulus 0.0035 0.003 0.0028
Trypanosoma cruzi hypothetical protein, conserved 0.0484 0.094 1
Echinococcus granulosus cpg binding protein 0.0037 0.0034 0.0033
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0484 0.094 1
Loa Loa (eye worm) hypothetical protein 0.0155 0.0274 0.0274
Plasmodium falciparum phosphodiesterase delta, putative 0.0484 0.094 1
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.031 0.0588 0.0588
Giardia lamblia Hypothetical protein 0.0484 0.094 0.0925
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0046 0.0053 0.0051
Onchocerca volvulus 0.0242 0.0451 0.1184
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0484 0.094 0.0939
Brugia malayi Sodium:neurotransmitter symporter family protein 0.031 0.0588 0.0639
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0526 0.1025 0.1124
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.003 0.0028
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.003 0.002
Loa Loa (eye worm) hypothetical protein 0.0484 0.094 0.094
Echinococcus granulosus integrin alpha ps 0.0089 0.0139 0.0138
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.4952 1 1
Loa Loa (eye worm) hypothetical protein 0.0484 0.094 0.094
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0484 0.094 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0047 0.0047
Echinococcus multilocularis integrin alpha ps 0.0043 0.0046 0.0044
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.031 0.0588 0.0588
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.031 0.0588 0.0586
Onchocerca volvulus 0.0231 0.0427 0.1118
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0526 0.1025 0.1025
Echinococcus granulosus uncharacterized sodium dependent transporter 0.031 0.0588 0.0586
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0526 0.1025 0.1023
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0526 0.1025 0.1025
Onchocerca volvulus 0.0594 0.1164 0.3143
Loa Loa (eye worm) hypothetical protein 0.1826 0.3662 0.3662
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0484 0.094 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0484 0.094 1
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0484 0.094 0.0939
Echinococcus granulosus glycine receptor subunit alpha 1 0.0526 0.1025 0.1023
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0052 0.0592
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0526 0.1025 0.1025
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0484 0.094 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.003 0.0028
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0526 0.1025 0.1025
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0484 0.094 0.0925
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0484 0.094 1
Brugia malayi hypothetical protein 0.0242 0.0451 0.0487
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0526 0.1025 0.1023
Brugia malayi Pre-SET motif family protein 0.003 0.002 0.0008
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0173 0.1691
Trypanosoma brucei trypanothione reductase 0.0046 0.0052 0.0247
Plasmodium falciparum phosphodiesterase gamma, putative 0.0484 0.094 1
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0484 0.094 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.003 0.0138
Loa Loa (eye worm) hypothetical protein 0.0526 0.1025 0.1025
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0484 0.094 0.0925
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.003 0.003
Echinococcus granulosus nAChR subunit 0.0283 0.0533 0.0532
Toxoplasma gondii hypothetical protein 0.031 0.0588 0.0572
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0484 0.094 0.0925
Loa Loa (eye worm) phosphofructokinase 0.0105 0.0173 0.0173
Schistosoma mansoni cpg binding protein 0.0037 0.0034 0.0034
Leishmania major hypothetical protein, conserved 0.0484 0.094 1
Plasmodium falciparum glutathione reductase 0.0046 0.0052 0.0382
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0484 0.094 0.0939
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.003 0.0141
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0484 0.094 1
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.1254 0.2503 0.2503
Onchocerca volvulus 0.0526 0.1025 0.2761
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0079 0.0077
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0484 0.094 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0079 0.0538
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0484 0.094 1
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0526 0.1025 0.1023
Trypanosoma cruzi hypothetical protein, conserved 0.0484 0.094 1
Toxoplasma gondii thioredoxin reductase 0.0046 0.0052 0.0035
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.031 0.0588 0.0588
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.0172 0.3728
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.031 0.0588 0.0586
Trichomonas vaginalis set domain proteins, putative 0.0231 0.0427 0.4438
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0484 0.094 1
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.1254 0.2503 0.2501
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.0172 0.3728
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.003 0.0138
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.4468 0.9019 1
Loa Loa (eye worm) hypothetical protein 0.0526 0.1025 0.1025
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0283 0.0533 0.0533
Brugia malayi Bromodomain containing protein 0.0037 0.0035 0.0025
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0484 0.094 1
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0484 0.094 0.0939
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0484 0.094 0.0925
Loa Loa (eye worm) hypothetical protein 0.1826 0.3662 0.3662
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0242 0.0451 0.0449
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.002 0.002
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0008 0.0006
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0526 0.1025 0.1023
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.003 0.0028
Schistosoma mansoni acetylcholine receptor-related 0.0242 0.0451 0.0451
Brugia malayi Sodium:neurotransmitter symporter family protein 0.031 0.0588 0.0639
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0484 0.094 1
Loa Loa (eye worm) hypothetical protein 0.0283 0.0533 0.0533
Echinococcus granulosus lysosomal alpha glucosidase 0.0157 0.0279 0.0277
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0052 0.0247
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0484 0.094 1
Trichomonas vaginalis conserved hypothetical protein 0.0484 0.094 1
Loa Loa (eye worm) hypothetical protein 0.0526 0.1025 0.1025
Echinococcus granulosus glycine receptor subunit beta 0.0526 0.1025 0.1023
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.002 0.0018
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0484 0.094 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0027 0.0027
Schistosoma mansoni neurotransmitter gated ion channel 0.0283 0.0533 0.0533
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0484 0.094 0.1031
Brugia malayi Thioredoxin reductase 0.0046 0.0052 0.0045
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.1254 0.2503 0.2501
Echinococcus granulosus serotonin transporter 0.1826 0.3662 0.3661
Plasmodium vivax SET domain protein, putative 0.003 0.002 0.0026
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0484 0.094 0.0939
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0484 0.094 1
Leishmania major ATP-dependent phosphofructokinase 0.0105 0.0173 0.1574
Loa Loa (eye worm) LGC-31 protein 0.0526 0.1025 0.1025
Echinococcus granulosus uncharacterized sodium dependent transporter 0.031 0.0588 0.0586
Echinococcus granulosus integrin alpha ps 0.0043 0.0046 0.0044
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0484 0.094 0.0925
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0484 0.094 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0484 0.094 0.0925
Schistosoma mansoni cpg binding protein 0.0033 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0283 0.0533 0.0533
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0526 0.1025 0.1025
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0526 0.1025 0.1025
Loa Loa (eye worm) hypothetical protein 0.0046 0.0053 0.0053
Loa Loa (eye worm) glutathione reductase 0.0046 0.0052 0.0052
Schistosoma mansoni zinc finger protein 0.0021 0.0002 0.0002
Trypanosoma cruzi hypothetical protein, conserved 0.0484 0.094 1
Onchocerca volvulus 0.1826 0.3662 1
Loa Loa (eye worm) hypothetical protein 0.0484 0.094 0.094
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.031 0.0588 0.0586
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.031 0.0588 0.0572
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.002 0.0002
Trichomonas vaginalis esterase, putative 0.0035 0.003 0.0138
Brugia malayi 6-phosphofructokinase 0.0105 0.0173 0.0179
Loa Loa (eye worm) hypothetical protein 0.0242 0.0451 0.0451
Loa Loa (eye worm) hypothetical protein 0.031 0.0588 0.0588
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.003 0.0138
Loa Loa (eye worm) hypothetical protein 0.0283 0.0533 0.0533
Loa Loa (eye worm) hypothetical protein 0.0283 0.0533 0.0533
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0484 0.094 1
Loa Loa (eye worm) hypothetical protein 0.0283 0.0533 0.0533
Echinococcus multilocularis cpg binding protein 0.0037 0.0034 0.0033
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0526 0.1025 0.1023
Schistosoma mansoni nAChR subunit 0.0526 0.1025 0.1025
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.003
Plasmodium vivax hypothetical protein, conserved 0.0035 0.003 0.0138
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0484 0.094 1
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0484 0.094 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0079 0.3415
Brugia malayi Glycosyl hydrolases family 31 protein 0.0157 0.0279 0.0296
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.0172 0.3728
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0526 0.1025 0.1023
Onchocerca volvulus 0.0283 0.0533 0.1411
Echinococcus granulosus integrin alpha 3 0.0152 0.0267 0.0265
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0173 0.1691
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.1254 0.2503 0.2501
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.031 0.0588 1
Brugia malayi hypothetical protein 0.0035 0.003 0.002
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0173 0.1691
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0484 0.094 0.1031
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.1254 0.2503 0.2501
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.031 0.0588 0.0586
Onchocerca volvulus 0.0283 0.0533 0.1411
Schistosoma mansoni nAChR subunit 0.0526 0.1025 0.1025
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0484 0.094 1
Schistosoma mansoni neurotransmitter gated ion channel 0.0242 0.0451 0.0451
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0484 0.094 0.094
Onchocerca volvulus 0.0594 0.1164 0.3143
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0526 0.1025 0.1023
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.0104 0.0104
Plasmodium vivax amine transporter, putative 0.031 0.0588 0.6182
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0081 0.0079
Plasmodium vivax phosphodiesterase gamma, putative 0.0484 0.094 1
Schistosoma mansoni hypothetical protein 0.0043 0.0046 0.0046
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0526 0.1025 0.1124
Onchocerca volvulus 0.031 0.0588 0.156
Schistosoma mansoni alpha-glucosidase 0.0135 0.0234 0.0234
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0526 0.1025 0.1124
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0526 0.1025 0.1124
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0526 0.1025 0.1124
Mycobacterium tuberculosis Probable reductase 0.0105 0.0172 0.3728
Loa Loa (eye worm) acetylcholine receptor protein 0.0242 0.0451 0.0451
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0484 0.094 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.1826 0.3662 0.3662
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0484 0.094 0.0925
Loa Loa (eye worm) hypothetical protein 0.0242 0.0451 0.0451
Loa Loa (eye worm) hypothetical protein 0.0242 0.0451 0.0451
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0484 0.094 0.094
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0079 0.0077
Trypanosoma brucei glucosidase, putative 0.0035 0.003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0526 0.1025 0.1025
Loa Loa (eye worm) hypothetical protein 0.0526 0.1025 0.1025
Echinococcus multilocularis glycine receptor subunit beta 0.0526 0.1025 0.1023
Echinococcus multilocularis nAChR subunit 0.0283 0.0533 0.0532
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0484 0.094 0.094
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0484 0.094 1
Echinococcus granulosus 6 phosphofructokinase 0.0105 0.0173 0.0172
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.4952 1 1
Mycobacterium ulcerans 6-phosphofructokinase 0.0105 0.0173 1
Loa Loa (eye worm) hypothetical protein 0.031 0.0588 0.0588
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.003 0.0138
Trypanosoma brucei hypothetical protein, conserved 0.0484 0.094 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.003
Brugia malayi Cytochrome P450 family protein 0.0051 0.0062 0.0056
Loa Loa (eye worm) hypothetical protein 0.031 0.0588 0.0588
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0484 0.094 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.003 0.0141
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0484 0.094 1
Loa Loa (eye worm) hypothetical protein 0.0109 0.0181 0.0181
Loa Loa (eye worm) solute carrier family 6 member 4 0.1826 0.3662 0.3662

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 33 uM In vitro inhibition of Prostaglandin G/H synthase 2 in human whole blood assay ChEMBL. 11327589
IC50 (binding) > 100 uM In vitro inhibition of Prostaglandin G/H synthase 1 in human whole blood assay ChEMBL. 11327589

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.