TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 478.595 | Formula: C30H35FO4
H donors: 1 H acceptors: 2 LogP: 7.93 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: CCC[C@@H](c1cccc(c1)OCc1ccc(c(c1)C(C)(C)C)c1cc(OC)ccc1F)CC(=O)O
InChi: 1S/C30H35FO4/c1-6-8-21(17-29(32)33)22-9-7-10-24(16-22)35-19-20-11-13-25(27(15-20)30(2,3)4)26-18-23(34-5)12-14-28(26)31/h7,9-16,18,21H,6,8,17,19H2,1-5H3,(H,32,33)/t21-/m1/s1
InChiKey: GOFGLMCLGYEAQR-OAQYLSRUSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	free fatty acid receptor 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	isocitrate dehydrogenase	0.0015	0.0008	0.0011
Loa Loa (eye worm)	SWIB/MDM2 domain-containing protein	0.1038	0.6953	1
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0015	0.0008	0.0032
Onchocerca volvulus		0.0369	0.2411	0.3467
Onchocerca volvulus		0.0231	0.1472	0.2117
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0094	0.0135
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0142	0.0204
Schistosoma mansoni	hypothetical protein	0.1038	0.6953	1
Trichomonas vaginalis	conserved hypothetical protein	0.1038	0.6953	1
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0142	0.0993
Trypanosoma cruzi	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0031	0.0128
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0031	0.0128
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0084	0.0472	0.0679
Mycobacterium ulcerans	lipase LipD	0.0035	0.0142	0.8279
Echinococcus granulosus	Nuclear pore complex protein Nup153	0.0369	0.2411	0.2411
Plasmodium vivax	zinc finger protein, putative	0.0019	0.0031	0.0044
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0142	0.0204
Giardia lamblia	Protein 21.1	0.0019	0.0031	1
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0031	0.0128
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0031	0.0044
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0142	0.0204
Schistosoma mansoni	hypothetical protein	0.1038	0.6953	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0031	0.0044
Loa Loa (eye worm)	brahma associated protein	0.1038	0.6953	1
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0031	0.0128
Trichomonas vaginalis	hypothetical protein	0.0019	0.0031	0.0044
Trypanosoma brucei	glucose transporter 2A	0.0031	0.0117	0.0484
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0024	0.0068	0.0068
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0117	0.0168
Trypanosoma brucei	Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0031	0.0128
Echinococcus granulosus	hyperpolarization activated cyclic	0.0017	0.0016	0.0016
Brugia malayi	beta-lactamase family protein	0.0035	0.0142	0.0204
Giardia lamblia	Protein 21.1	0.0019	0.0031	1
Leishmania major	hypothetical protein, conserved	0.0019	0.0031	0.0128
Echinococcus granulosus	zinc finger protein Ran binding	0.0369	0.2411	0.2411
Brugia malayi	hypothetical protein	0.0019	0.0031	0.0044
Brugia malayi	beta-lactamase family protein	0.0035	0.0142	0.0204
Trypanosoma brucei	DNA repair protein, putative	0.0019	0.0031	0.0128
Onchocerca volvulus		0.0019	0.0031	0.0044
Giardia lamblia	Kinase	0.0019	0.0031	1
Trypanosoma cruzi	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0031	0.0128
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0142	0.0204
Plasmodium falciparum	zinc finger Ran-binding domain-containing protein 2, putative	0.0369	0.2411	0.3467
Echinococcus granulosus	General substrate transporter	0.0087	0.0495	0.0495
Plasmodium falciparum	E3 ubiquitin-protein ligase RNF5, putative	0.0019	0.0031	0.0044
Schistosoma mansoni	peter pan-related	0.0019	0.0031	0.0044
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0017	0.0016	0.0023
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0117	0.0168
Plasmodium falciparum	trophozoite exported protein 1	0.0019	0.0031	0.0044
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0094	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0031	0.0044
Echinococcus granulosus	RING finger and transmembrane domain containing protein	0.0019	0.0031	0.0031
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0031	0.0128
Echinococcus granulosus	E3 ubiquitin protein ligase LRSAM1	0.0019	0.0031	0.0031
Plasmodium vivax	hexose transporter	0.0101	0.0592	0.0851
Trypanosoma cruzi	hexose transporter, putative	0.0031	0.0117	0.0484
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0101	0.0145
Onchocerca volvulus		0.0019	0.0031	0.0044
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0142	0.0142
Trypanosoma cruzi	WLM domain containing protein, putative	0.0369	0.2411	1
Trypanosoma cruzi	cytochrome P450, putative	0.0039	0.0171	0.071
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0101	0.0101
Schistosoma mansoni	hypothetical protein	0.0019	0.0031	0.0044
Trypanosoma cruzi	hypothetical protein, conserved	0.0019	0.0031	0.0128
Trypanosoma cruzi	hypothetical protein, conserved	0.0019	0.0031	0.0128
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0024	0.0068	0.0068
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0015	0.0008	0.0032
Brugia malayi	SWIB/MDM2 domain containing protein	0.1038	0.6953	1
Trichomonas vaginalis	glucose transporter, putative	0.0031	0.0117	0.0168
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0017	0.0016	0.0023
Plasmodium vivax	hypothetical protein, conserved	0.1038	0.6953	1
Onchocerca volvulus		0.0369	0.2411	0.3467
Trypanosoma brucei	cytochrome P450, putative	0.0039	0.0171	0.071
Giardia lamblia	Protein 21.1	0.0019	0.0031	1
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0031	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0397	0.0571
Echinococcus multilocularis	Zinc finger, RanBP2 type	0.0369	0.2411	0.2411
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0031	0.0044
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0117	0.0484
Trichomonas vaginalis	sex-determining protein fem-1, putative	0.0019	0.0031	0.0044
Plasmodium vivax	E3 ubiquitin-protein ligase RNF5, putative	0.0019	0.0031	0.0044
Giardia lamblia	Protein 21.1	0.0019	0.0031	1
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0031	0.0044
Toxoplasma gondii	RING zinc finger protein	0.0019	0.0031	0.0044
Echinococcus granulosus	E3 ubiquitin protein ligase Bre1	0.0019	0.0031	0.0031
Brugia malayi	YY1-associated factor 2	0.0369	0.2411	0.3467
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0015	0.0008	0.0055
Leishmania major	hypothetical protein, conserved	0.0019	0.0031	0.0128
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0031	0.0044
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0101	0.0592	0.0592
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0015	0.0008	0.0032
Schistosoma mansoni	brg-1 associated factor	0.1038	0.6953	1
Loa Loa (eye worm)	CYP4Cod1	0.0039	0.0171	0.0246
Trypanosoma cruzi	hypothetical protein, conserved	0.0019	0.0031	0.0128
Brugia malayi	hypothetical protein	0.0019	0.0031	0.0044
Brugia malayi	Zinc finger protein 183 homolog	0.0019	0.0031	0.0044
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0084	0.0472	0.0472
Trichomonas vaginalis	ubiquitin-protein ligase BRE1, putative	0.0019	0.0031	0.0044
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0008	0.0008
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0031	0.0117	0.0484
Giardia lamblia	Hypothetical protein	0.0019	0.0031	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0031	0.0117	0.0484
Echinococcus multilocularis	SWI:SNF matrix associated	0.1038	0.6953	0.6953
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0078	0.0435	0.0625
Schistosoma mansoni	glucose transport protein	0.0101	0.0592	0.0851
Schistosoma mansoni	voltage-gated potassium channel	0.0091	0.0524	0.0754
Loa Loa (eye worm)	cytochrome P450 family protein	0.0039	0.0171	0.0246
Giardia lamblia	Protein 21.1	0.0019	0.0031	1
Brugia malayi	Cytochrome P450 family protein	0.0039	0.0171	0.0246
Echinococcus multilocularis	General substrate transporter	0.0087	0.0495	0.0495
Leishmania major	hypothetical protein, conserved	0.0369	0.2411	1
Giardia lamblia	Protein 21.1	0.0019	0.0031	1
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0015	0.0008	0.0008
Trypanosoma brucei	ring finger containing protein	0.0019	0.0031	0.0128
Brugia malayi	brahma associated protein 60 kDa	0.1038	0.6953	1
Trypanosoma brucei	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0031	0.0128
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0031	0.0044
Leishmania major	hypothetical protein, conserved	0.0369	0.2411	1
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.0142	0.0993
Loa Loa (eye worm)	hypothetical protein	0.0369	0.2411	0.3467
Trypanosoma cruzi	hypothetical protein, conserved	0.0369	0.2411	1
Schistosoma mansoni	inhibitor of apoptosis 1 diap1	0.0019	0.0031	0.0044
Entamoeba histolytica	zinc finger domain containing protein	0.0019	0.0031	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0117	0.0168
Schistosoma mansoni	RNA binding protein	0.0369	0.2411	0.3467
Trypanosoma cruzi	hypothetical protein, conserved	0.0369	0.2411	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0039	0.0171	0.0246
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0008	0.0008
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0117	0.0168
Trypanosoma cruzi	hypothetical protein, conserved	0.0019	0.0031	0.0128
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0117	0.0484
Trypanosoma brucei	hypothetical protein, conserved	0.0369	0.2411	1
Trypanosoma cruzi	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0031	0.0128
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0084	0.0472	0.0472
Brugia malayi	MH2 domain containing protein	0.0116	0.0694	0.0998
Trypanosoma brucei	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0031	0.0128
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0101	0.0592	0.0592
Trypanosoma cruzi	Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0031	0.0128
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0015	0.0008	0.0011
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0017	0.0016	0.0016
Entamoeba histolytica	zinc finger domain containing protein	0.0019	0.0031	0.5
Schistosoma mansoni	zinc finger protein	0.0369	0.2411	0.3467
Brugia malayi	hypothetical protein	0.0019	0.0031	0.0044
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.0142	0.0993
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0031	0.0044
Trypanosoma cruzi	hypothetical protein, conserved	0.0019	0.0031	0.0128
Entamoeba histolytica	zinc finger domain containing protein	0.0019	0.0031	0.5
Trypanosoma cruzi	Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0031	0.0128
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0017	0.0016	0.0016
Toxoplasma gondii	Zn-finger in Ran binding protein and others domain-containing protein	0.0369	0.2411	0.3467
Echinococcus multilocularis	E3 ubiquitin protein ligase mib1	0.0019	0.0031	0.0031
Leishmania major	hypothetical protein, conserved	0.0019	0.0031	0.0128
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0031	0.0044
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0031	0.0044
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0031	0.0044
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0101	0.0145
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0017	0.0016	0.0023
Trichomonas vaginalis	ubiquitin-protein ligase BRE1, putative	0.0019	0.0031	0.0044
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0031	0.0044
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0142	0.8279
Brugia malayi	Cytochrome P450 family protein	0.0039	0.0171	0.0246
Giardia lamblia	Ser/Thr protein kinase	0.0019	0.0031	1
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.0031	0.0044
Leishmania major	hypothetical protein	0.0019	0.0031	0.0128
Schistosoma mansoni	zinc finger protein	0.0019	0.0031	0.0044
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative	0.0019	0.0031	0.0128
Trypanosoma cruzi	hypothetical protein, conserved	0.0019	0.0031	0.0128
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0369	0.2411	0.3467
Trypanosoma brucei	predicted zinc finger protein	0.0019	0.0031	0.0128
Schistosoma mansoni	hypothetical protein	0.0101	0.0592	0.0851
Schistosoma mansoni	voltage-gated potassium channel	0.0024	0.0068	0.0098
Trypanosoma brucei	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0031	0.0128
Schistosoma mansoni	hypothetical protein	0.1038	0.6953	1
Onchocerca volvulus	Protein neuralized homolog	0.0019	0.0031	0.0044
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0031	0.0128
Toxoplasma gondii	helicase, putative	0.0019	0.0031	0.0044
Echinococcus multilocularis	ring finger protein 113a	0.0019	0.0031	0.0031
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0031	0.0128
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0031	0.0128
Leishmania major	cytochrome p450-like protein	0.0039	0.0171	0.071
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0142	0.0204
Trypanosoma cruzi	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0369	0.2411	1
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0031	0.0128
Toxoplasma gondii	hypothetical protein	0.0019	0.0031	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0142	0.0204
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0031	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0031	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0218	0.1381	0.1986
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0017	0.0016	0.0023
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0031	0.0128
Brugia malayi	hypothetical protein	0.0019	0.0031	0.0044
Trichomonas vaginalis	conserved hypothetical protein	0.0101	0.0592	0.0851
Entamoeba histolytica	zinc finger domain containing protein	0.0019	0.0031	0.5
Onchocerca volvulus		0.0019	0.0031	0.0044
Giardia lamblia	Protein 21.1	0.0019	0.0031	1
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0031	0.0044
Giardia lamblia	Protein 21.1	0.0019	0.0031	1
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0031	0.0128
Echinococcus granulosus	microtubule associated protein 2	0.0673	0.4475	0.4475
Giardia lamblia	Hypothetical protein	0.0019	0.0031	1
Schistosoma mansoni	fusion	0.0369	0.2411	0.3467
Trypanosoma cruzi	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0031	0.0128
Onchocerca volvulus	Ubiquitin thioesterase ZRANB1 homolog	0.0369	0.2411	0.3467
Leishmania major	hypothetical protein, conserved	0.0019	0.0031	0.0128
Schistosoma mansoni	voltage-gated potassium channel	0.0024	0.0068	0.0098
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0017	0.0016	0.0016
Leishmania major	hypothetical protein, conserved	0.0019	0.0031	0.0128
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0031	0.0044
Giardia lamblia	Protein 21.1	0.0019	0.0031	1
Echinococcus multilocularis	isocitrate dehydrogenase	0.0015	0.0008	0.0008
Echinococcus granulosus	ring finger protein 113a	0.0019	0.0031	0.0031
Echinococcus multilocularis	Upstream activation factor subunit UAF30	0.1038	0.6953	0.6953
Giardia lamblia	Protein 21.1	0.0019	0.0031	1
Toxoplasma gondii	hypothetical protein	0.0019	0.0031	0.0044
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0031	0.0128
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0031	0.0044
Giardia lamblia	Protein 21.1	0.0019	0.0031	1
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0015	0.0008	0.0008
Echinococcus granulosus	E3 ubiquitin protein ligase MYLIP	0.0019	0.0031	0.0031
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0015	0.0008	0.0032
Toxoplasma gondii	ran binding protein	0.0369	0.2411	0.3467
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0031	0.0044
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0369	0.2411	1
Toxoplasma gondii	zinc finger, C3HC4 type (RING finger) domain-containing protein	0.0019	0.0031	0.0044
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0031	0.0044
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0031	0.0044
Brugia malayi	Isocitrate dehydrogenase	0.0015	0.0008	0.0011
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0117	0.0484
Giardia lamblia	Protein 21.1	0.0019	0.0031	1
Leishmania major	hypothetical protein, conserved	0.0019	0.0031	0.0128
Echinococcus granulosus	cell growth regulator with ring finger domain	0.0019	0.0031	0.0031
Brugia malayi	RING zinc finger protein	0.0019	0.0031	0.0044
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0017	0.0016	0.0023
Onchocerca volvulus		0.0029	0.0101	0.0145
Toxoplasma gondii	hypothetical protein	0.0019	0.0031	0.0044
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0078	0.0435	0.0625
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0142	0.0204
Leishmania major	glucose transporter, lmgt1	0.0031	0.0117	0.0484
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0031	0.0044
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0031	0.0044
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0019	0.0031	0.0044
Echinococcus multilocularis	E3 ubiquitin protein ligase MYLIP	0.0019	0.0031	0.0031
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.1038	0.6953	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0142	0.0204
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0203	0.1282	0.1844
Loa Loa (eye worm)	MH2 domain-containing protein	0.0116	0.0694	0.0998
Echinococcus multilocularis	RING finger and transmembrane domain containing protein	0.0019	0.0031	0.0031
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0015	0.0008	0.0011
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0224	0.1427	1
Schistosoma mansoni	TRABID protein (C64 family)	0.0369	0.2411	0.3467
Echinococcus granulosus	E3 ubiquitin protein ligase RNF146	0.0019	0.0031	0.0031
Leishmania major	hypothetical protein, conserved	0.0035	0.0142	0.0588
Onchocerca volvulus		0.0035	0.0142	0.0204
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0142	0.0204
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0142	0.0588
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0068	0.0098
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0101	0.0592	0.0592
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0101	0.0145
Schistosoma mansoni	microtubule-associated protein tau	0.0673	0.4475	0.6435
Echinococcus multilocularis	zinc finger protein Ran binding	0.0369	0.2411	0.2411
Toxoplasma gondii	isocitrate dehydrogenase	0.0015	0.0008	0.0011
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0015	0.0008	0.0011
Leishmania major	hypothetical protein, conserved	0.0019	0.0031	0.0128
Leishmania major	hypothetical protein, conserved	0.0019	0.0031	0.0128
Trypanosoma brucei	glucose transporter 1E	0.0031	0.0117	0.0484
Trypanosoma cruzi	hexose transporter	0.0031	0.0117	0.0484
Trypanosoma cruzi	hypothetical protein, conserved	0.0019	0.0031	0.0128
Schistosoma mansoni	glucose transport protein	0.0101	0.0592	0.0851
Loa Loa (eye worm)	RING finger protein 20	0.0019	0.0031	0.0044
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0117	0.0484
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0117	0.0168
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0031	0.0044
Echinococcus granulosus	Upstream activation factor subunit UAF30	0.1038	0.6953	0.6953
Trichomonas vaginalis	glucose transporter, putative	0.0031	0.0117	0.0168
Trypanosoma cruzi	hexose transporter, putative	0.0031	0.0117	0.0484
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0017	0.0016	0.0016
Onchocerca volvulus		0.0019	0.0031	0.0044
Entamoeba histolytica	zinc finger domain containing protein	0.0019	0.0031	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0031	0.0044
Giardia lamblia	Hypothetical protein	0.0019	0.0031	1
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0031	0.0128
Giardia lamblia	Kinase, NEK	0.0019	0.0031	1
Leishmania major	glucose transporter, lmgt2	0.0031	0.0117	0.0484
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0142	0.8279
Trypanosoma brucei	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0369	0.2411	1
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0017	0.0016	0.0016
Giardia lamblia	Protein 21.1	0.0019	0.0031	1
Brugia malayi	hypothetical protein	0.0019	0.0031	0.0044
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0142	0.0204
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0031	0.0128
Trichomonas vaginalis	ankyrin, putative	0.0019	0.0031	0.0044
Toxoplasma gondii	SWIB/MDM2 domain-containing protein	0.1038	0.6953	1
Entamoeba histolytica	zinc finger domain containing protein	0.0019	0.0031	0.5
Trichomonas vaginalis	set domain proteins, putative	0.0231	0.1472	0.2117
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.0142	0.0993
Schistosoma mansoni	ring finger protein 151	0.0019	0.0031	0.0044
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.0142	0.0993
Echinococcus granulosus	ring and YY1 binding protein	0.0369	0.2411	0.2411
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0142	0.0204
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0142	0.0142
Echinococcus granulosus	SWI:SNF matrix associated	0.1038	0.6953	0.6953
Giardia lamblia	Protein 21.1	0.0019	0.0031	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0101	0.0592	0.0592
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0015	0.0008	0.0011
Leishmania major	hypothetical protein, conserved	0.0369	0.2411	1
Toxoplasma gondii	facilitative glucose transporter GT1	0.0101	0.0592	0.0851
Giardia lamblia	Hypothetical protein	0.0019	0.0031	1
Brugia malayi	Pre-SET motif family protein	0.0029	0.0101	0.0145
Echinococcus granulosus	E3 ubiquitin protein ligase mib1	0.0019	0.0031	0.0031
Onchocerca volvulus		0.0035	0.0142	0.0204
Trypanosoma cruzi	hypothetical protein, conserved	0.0369	0.2411	1
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger) containing protein, putative	0.0019	0.0031	0.0128
Entamoeba histolytica	SPRY domain protein	0.0019	0.0031	0.5
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0101	0.0592	0.0592
Schistosoma mansoni	mind bomb	0.0019	0.0031	0.0044
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0031	0.0128
Loa Loa (eye worm)	RiNg Finger protein family member	0.0019	0.0031	0.0044
Trypanosoma cruzi	hexose transporter, putative	0.0031	0.0117	0.0484
Loa Loa (eye worm)	hypothetical protein	0.0369	0.2411	0.3467
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0369	0.2411	1
Loa Loa (eye worm)	sugar transporter	0.0101	0.0592	0.0851
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0142	0.0993
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.0142	0.0993
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0369	0.2411	1
Plasmodium vivax	DNA repair protein RAD5, putative	0.0019	0.0031	0.0044
Giardia lamblia	Ribonuclease	0.0019	0.0031	1
Leishmania major	hypothetical protein, conserved	0.0369	0.2411	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0142	0.0204
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0101	0.0145
Trichomonas vaginalis	ankyrin repeat domain protein, putative	0.0019	0.0031	0.0044
Entamoeba histolytica	hypothetical protein	0.0019	0.0031	0.5
Giardia lamblia	Protein 21.1	0.0019	0.0031	1
Chlamydia trachomatis	SWIB complex protein	0.1038	0.6953	0.5
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0117	0.0484
Echinococcus multilocularis		0.0019	0.0031	0.0031
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0142	0.0588
Onchocerca volvulus		0.0369	0.2411	0.3467
Echinococcus multilocularis	E3 ubiquitin protein ligase LRSAM1	0.0019	0.0031	0.0031
Leishmania major	hypothetical protein, conserved	0.0019	0.0031	0.0128
Toxoplasma gondii	zinc finger, C3HC4 type (RING finger) domain-containing protein	0.0019	0.0031	0.0044
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0017	0.0016	0.0016
Brugia malayi	RING finger protein 20	0.0019	0.0031	0.0044
Plasmodium vivax	trophozoite exported protein 1, putative	0.0019	0.0031	0.0044
Echinococcus multilocularis	microtubule associated protein 2	0.0673	0.4475	0.4475
Giardia lamblia	E3 ubiquitin ligase for Rad6p required for the ubiquitination of histone H2B	0.0019	0.0031	1
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0101	0.0101
Trypanosoma cruzi	hexose transporter, putative	0.0017	0.002	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0031	0.0044
Echinococcus multilocularis	RING finger protein 185	0.0019	0.0031	0.0031
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0019	0.0031	0.0044
Plasmodium falciparum	zinc finger protein, putative	0.0019	0.0031	0.0044
Giardia lamblia	Zinc finger domain	0.0019	0.0031	1
Giardia lamblia	Protein 21.1	0.0019	0.0031	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0142	0.0588
Giardia lamblia	Protein 21.1	0.0019	0.0031	1
Brugia malayi	Neuralized family protein	0.0019	0.0031	0.0044
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0017	0.0016	0.0023
Toxoplasma gondii	Bardet-Biedl syndrome 5, putative	0.0019	0.0031	0.0044
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0017	0.0016	0.0016
Schistosoma mansoni	glucose transport protein	0.0101	0.0592	0.0851
Brugia malayi	Zinc finger, C2H2 type family protein	0.0019	0.0031	0.0044
Brugia malayi	beta-lactamase	0.0035	0.0142	0.0204
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0369	0.2411	1
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0031	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0369	0.2411	0.3467
Onchocerca volvulus		0.0035	0.0142	0.0204
Trichomonas vaginalis	esterase, putative	0.0035	0.0142	0.0204
Onchocerca volvulus		0.0019	0.0031	0.0044
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0142	0.0204
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0031	0.0044
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0031	0.0128
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0031	0.0128
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0142	0.0204
Giardia lamblia	Protein 21.1	0.0019	0.0031	1
Leishmania major	hypothetical protein, conserved	0.0019	0.0031	0.0128
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0369	0.2411	0.3467
Echinococcus granulosus	voltage gated potassium channel	0.0024	0.0068	0.0068
Giardia lamblia	Hypothetical protein	0.0019	0.0031	1
Plasmodium vivax	E3 ubiquitin-protein ligase, putative	0.0019	0.0031	0.0044
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0031	0.0128
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative	0.0019	0.0031	0.0128
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0019	0.0031	0.0044
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0031	0.0128
Plasmodium falciparum	hexose transporter	0.0101	0.0592	0.0851
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0031	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0142	0.0204
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.0101	0.0101
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0084	0.0472	0.0679
Entamoeba histolytica	zinc finger domain containing protein	0.0019	0.0031	0.5
Echinococcus multilocularis	ring and YY1 binding protein	0.0369	0.2411	0.2411
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0015	0.0008	0.0032
Trichomonas vaginalis	ubiquitin-protein ligase BRE1, putative	0.0019	0.0031	0.0044
Giardia lamblia	Protein 21.1	0.0019	0.0031	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0116	0.0694	0.0998
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0031	0.0128
Brugia malayi	Sugar transporter family protein	0.0101	0.0592	0.0851
Giardia lamblia	Hypothetical protein	0.0019	0.0031	1
Brugia malayi	Hypothetical RING finger protein C16C10.7 in chromosome III	0.0019	0.0031	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0369	0.2411	0.3467
Giardia lamblia	Protein 21.1	0.0019	0.0031	1
Chlamydia trachomatis	DNA topoisomerase I	0.1038	0.6953	0.5
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0142	0.8279
Echinococcus granulosus	ring finger protein 170	0.0019	0.0031	0.0031
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0008	0.0008
Onchocerca volvulus		0.1038	0.6953	1
Toxoplasma gondii	ABC1 family protein	0.0035	0.0142	0.0204
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0031	0.0044
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0142	0.5
Giardia lamblia	Protein 21.1	0.0019	0.0031	1
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0017	0.0016	0.0016
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0017	0.0016	0.0023
Trypanosoma cruzi	hypothetical protein	0.0019	0.0031	0.0128
Echinococcus multilocularis	ring finger protein 170	0.0019	0.0031	0.0031
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0142	0.8279
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0031	0.0128
Onchocerca volvulus		0.0019	0.0031	0.0044
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.0142	0.0993
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0031	0.0128
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.1038	0.6953	1
Leishmania major	hypothetical protein, conserved	0.0019	0.0031	0.0128
Brugia malayi	B-box zinc finger family protein	0.0019	0.0031	0.0044
Trichomonas vaginalis	ankyrin, putative	0.0019	0.0031	0.0044
Brugia malayi	brahma associated protein 60 kDa	0.1038	0.6953	1
Echinococcus multilocularis	E3 ubiquitin protein ligase Bre1	0.0019	0.0031	0.0031
Trypanosoma cruzi	cytochrome P450, putative	0.0039	0.0171	0.071
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0016	0.0023
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.0142	0.0993
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0031	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0369	0.2411	0.3467
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.0101	0.0145
Schistosoma mansoni	peter pan-related	0.0019	0.0031	0.0044
Giardia lamblia	Zinc finger domain	0.0019	0.0031	1
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0369	0.2411	0.3467
Echinococcus granulosus	RING finger protein 185	0.0019	0.0031	0.0031
Leishmania major	hypothetical protein, conserved	0.0369	0.2411	1
Onchocerca volvulus		0.0218	0.1381	0.1986
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0017	0.0016	0.0016
Leishmania major	glucose transporter, lmgt3	0.0031	0.0117	0.0484
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0142	0.0993
Trichomonas vaginalis	cell cycle control protein cwf24, putative	0.0019	0.0031	0.0044
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0369	0.2411	0.3467
Echinococcus granulosus	hyperpolarization activated cyclic	0.0017	0.0016	0.0016
Brugia malayi	Pre-SET motif family protein	0.0203	0.1282	0.1844
Echinococcus granulosus	Zinc finger RanBP2 type	0.0369	0.2411	0.2411
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0031	0.0128
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0031	0.0044
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0017	0.0016	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0142	0.0204
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0031	0.0128
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0101	0.0592	0.0592
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0031	0.0044
Toxoplasma gondii	hypothetical protein	0.0019	0.0031	0.0044
Toxoplasma gondii	isocitrate dehydrogenase	0.0015	0.0008	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0031	0.0044
Trypanosoma brucei	SNF2 family N-terminal domain/Ring finger domain containing protein, putative	0.0019	0.0031	0.0128
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0017	0.0016	0.0023
Trypanosoma cruzi	WLM domain containing protein, putative	0.0369	0.2411	1
Leishmania major	hypothetical protein, conserved	0.0019	0.0031	0.0128
Giardia lamblia	Hypothetical protein	0.0019	0.0031	1
Leishmania major	hypothetical protein, unknown function	0.0019	0.0031	0.0128
Echinococcus multilocularis	SWI:SNF matrix associated	0.1038	0.6953	0.6953
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0031	0.0128
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0031	0.0044
Plasmodium vivax	RING zinc finger protein, putative	0.0019	0.0031	0.0044
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0039	0.0171	1
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0031	0.0044
Leishmania major	hypothetical protein, conserved	0.0019	0.0031	0.0128
Onchocerca volvulus		0.0369	0.2411	0.3467
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0031	0.0117	0.0484
Schistosoma mansoni	hypothetical protein	0.0019	0.0031	0.0044
Trypanosoma brucei	mitochondrial RNA binding complex 1 subunit	0.0369	0.2411	1
Schistosoma mansoni	voltage-gated potassium channel	0.0091	0.0524	0.0754
Echinococcus multilocularis	SWI:SNF matrix associated	0.1038	0.6953	0.6953
Toxoplasma gondii	DNA topoisomerase domain-containing protein	0.1038	0.6953	1
Trypanosoma brucei	hypothetical protein, conserved	0.0369	0.2411	1
Schistosoma mansoni	hypothetical protein	0.0019	0.0031	0.0044
Entamoeba histolytica	zinc finger domain containing protein	0.0019	0.0031	0.5
Trichomonas vaginalis	ion channel nompc, putative	0.0019	0.0031	0.0044
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0101	0.0145
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0142	0.0204
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0019	0.0031	0.0044
Leishmania major	DNA repair protein-like protein	0.0019	0.0031	0.0128
Schistosoma mansoni	hypothetical protein	0.0369	0.2411	0.3467
Giardia lamblia	Protein 21.1	0.0019	0.0031	1
Plasmodium falciparum	RING zinc finger protein, putative	0.0019	0.0031	0.0044
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0117	0.0484
Schistosoma mansoni	cellular tumor antigen P53	0.0218	0.1381	0.1986
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0031	0.0117	0.0484
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0101	0.0592	0.0592
Schistosoma mansoni	rnf5	0.0019	0.0031	0.0044
Trypanosoma cruzi	hypothetical protein	0.0019	0.0031	0.0128
Plasmodium vivax	SWIB/MDM2 domain-containing protein, putative	0.1038	0.6953	1
Echinococcus multilocularis	Nuclear pore complex protein Nup153	0.0369	0.2411	0.2411
Onchocerca volvulus	RING finger protein 141 homolog	0.0019	0.0031	0.0044
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0024	0.0068	0.0098
Trichomonas vaginalis	ankyrin, putative	0.0019	0.0031	0.0044
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0117	0.0484
Mycobacterium leprae	Probable lipase LipE	0.0035	0.0142	0.5
Brugia malayi	hypothetical protein	0.0019	0.0031	0.0044
Plasmodium falciparum	E3 ubiquitin-protein ligase, putative	0.0019	0.0031	0.0044
Plasmodium vivax	SET domain protein, putative	0.0029	0.0101	0.0145
Onchocerca volvulus	Putative RING finger protein 207	0.0019	0.0031	0.0044
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0017	0.0016	0.0023
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0117	0.0484
Giardia lamblia	Protein 21.1	0.0019	0.0031	1
Giardia lamblia	Protein 21.1	0.0019	0.0031	1
Echinococcus multilocularis	voltage gated potassium channel	0.0024	0.0068	0.0068
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0031	0.0128
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0101	0.0592	0.0592
Toxoplasma gondii	SWI2/SNF2-containing protein RAD5	0.0019	0.0031	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0031	0.0044
Entamoeba histolytica	hypothetical protein	0.0019	0.0031	0.5
Giardia lamblia	Kinase, NEK	0.0019	0.0031	1
Schistosoma mansoni	voltage-gated potassium channel	0.0017	0.0016	0.0023

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 0.69 uM	Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum	ChEMBL.	24900539
Efficacy (functional)	= 94 %	Agonist activity at GPR40 expressed in CHO cells assessed as intrinsic efficacy after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum relative to AM-1638	ChEMBL.	24900539

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2151296

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1723473