Detailed information for compound 1726662

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 495.91 | Formula: C19H12ClF2N5O3S2
  • H donors: 2 H acceptors: 5 LogP: 4.18 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(c(c1)c1ccc(nc1)N)Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1
  • InChi: 1S/C19H12ClF2N5O3S2/c20-11-2-3-15(12(5-11)10-1-4-18(23)24-8-10)30-16-6-14(22)17(7-13(16)21)32(28,29)27-19-25-9-26-31-19/h1-9H,(H2,23,24)(H,25,26,27)
  • InChiKey: HXJFRNKWNZRTJK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens sodium channel, voltage-gated, type IX, alpha subunit Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania donovani calcium channel protein, putative Get druggable targets OG5_126819 All targets in OG5_126819
Leishmania major calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit Get druggable targets OG5_126819 All targets in OG5_126819
Echinococcus granulosus sodium channel protein Get druggable targets OG5_126819 All targets in OG5_126819
Leishmania mexicana calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
Echinococcus multilocularis sodium channel protein Get druggable targets OG5_126819 All targets in OG5_126819
Leishmania braziliensis calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
Leishmania infantum calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) cytochrome P450 family protein 0.0056 0.0886 0.0972
Echinococcus granulosus cytochrome P450 2K1 0.0047 0.0665 0.0797
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.032 0.0243
Echinococcus multilocularis lysyl tRNA synthetase 0.0024 0.0132 0.0118
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0345 0.086
Loa Loa (eye worm) hypothetical protein 0.0032 0.032 0.0243
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0335 0.0378
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0359 0.789 1
Schistosoma mansoni glucose transport protein 0.0106 0.2038 0.2457
Loa Loa (eye worm) hypothetical protein 0.0178 0.37 0.4599
Trypanosoma brucei glucose transporter, putative 0.0033 0.0345 0.086
Echinococcus multilocularis voltage dependent calcium channel 0.0359 0.789 1
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0047 0.0665 0.225
Trypanosoma brucei glucose transporter, putative 0.0033 0.0345 0.086
Plasmodium falciparum calcium-dependent protein kinase 3 0.0033 0.0336 0.0207
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0171 0.355 0.3464
Echinococcus granulosus voltage dependent calcium channel 0.0359 0.789 1
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.032 0.1297
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.032 0.0358
Loa Loa (eye worm) hypothetical protein 0.0032 0.0335 0.0263
Loa Loa (eye worm) hypothetical protein 0.0359 0.789 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0442 0.1693
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0335 0.0378
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.2038 0.2546
Loa Loa (eye worm) hypothetical protein 0.0063 0.1035 0.1164
Echinococcus multilocularis Polycystic kidney disease protein 0.0063 0.1035 0.1268
Plasmodium vivax multidomain scavenger receptor, putative 0.0063 0.1035 0.0915
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0047 0.0665 0.225
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0047 0.0665 0.2511
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0345 0.1423
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0359 0.789 1
Trypanosoma brucei glucose transporter, putative 0.0033 0.0345 0.086
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0047 0.0665 0.2511
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0047 0.0665 0.2511
Trypanosoma cruzi hexose transporter 0.0033 0.0345 0.1321
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0345 0.1423
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0047 0.0665 0.225
Plasmodium falciparum mitogen-activated protein kinase 2 0.0171 0.355 0.3464
Loa Loa (eye worm) hypothetical protein 0.0063 0.1035 0.1164
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0033 0.0336 0.0207
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0171 0.355 0.5352
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0345 0.1321
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0132 0.0342
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0335 0.0263
Plasmodium falciparum proline--tRNA ligase 0.0037 0.0442 0.0315
Loa Loa (eye worm) doublecortin family protein 0.0063 0.1035 0.1164
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0047 0.0665 0.2511
Brugia malayi bHLH-PAS transcription factor 0.0039 0.0492 0.0464
Schistosoma mansoni hypothetical protein 0.0063 0.1035 0.1164
Schistosoma mansoni loxhd1 0.0063 0.1035 0.1164
Leishmania major cytochrome p450-like protein 0.0056 0.0886 0.3183
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0345 0.1321
Onchocerca volvulus 0.0063 0.1035 1
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0033 0.0336 0.0207
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0047 0.0665 0.225
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0345 0.1423
Plasmodium vivax hexose transporter 0.0106 0.2038 0.1932
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0047 0.0665 0.225
Echinococcus granulosus voltage dependent calcium channel 0.0053 0.0819 0.0994
Echinococcus granulosus Polycystic kidney disease protein 0.0063 0.1035 0.1268
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0047 0.0665 0.2511
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0335 0.0263
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0033 0.0336 0.032
Schistosoma mansoni aryl hydrocarbon receptor 0.0053 0.0811 0.0875
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0033 0.0336 0.0207
Loa Loa (eye worm) hypothetical protein 0.0036 0.0411 0.036
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.2038 0.2546
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0047 0.0665 0.2511
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0119 0.234 0.9343
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0119 0.234 0.932
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0047 0.0665 0.2511
Brugia malayi hypothetical protein 0.0178 0.37 0.4599
Brugia malayi cytochrome P450 0.0047 0.0665 0.0687
Schistosoma mansoni hypothetical protein 0.0047 0.0665 0.0687
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0442 0.131
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0359 0.789 1
Plasmodium falciparum LCCL domain-containing protein 0.0063 0.1035 0.0915
Schistosoma mansoni voltage-gated cation channel 0.0359 0.789 1
Brugia malayi hypoxia-induced factor 1 0.0164 0.3381 0.4188
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.2038 0.2546
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0024 0.0132 0.0505
Plasmodium vivax proline--tRNA ligase, putative 0.0037 0.0442 0.0315
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0033 0.0336 0.032
Toxoplasma gondii protein kinase, putative 0.03 0.6518 1
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0047 0.0665 0.225
Trypanosoma brucei glucose transporter 2A 0.0033 0.0345 0.086
Leishmania major cytochrome p450-like protein 0.0047 0.0665 0.225
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0047 0.0665 0.2511
Plasmodium falciparum calcium-dependent protein kinase 5 0.0033 0.0336 0.0207
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0047 0.0665 0.2511
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0047 0.0665 0.2511
Chlamydia trachomatis lysine--tRNA ligase 0.0024 0.0132 0.5
Echinococcus multilocularis General substrate transporter 0.0091 0.1693 0.2107
Echinococcus multilocularis RUN 0.0063 0.1035 0.1268
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0359 0.789 1
Schistosoma mansoni aldehyde dehydrogenase 0.0126 0.2501 0.3054
Plasmodium falciparum calcium-dependent protein kinase 4 0.0033 0.0336 0.0207
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0047 0.0665 0.225
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.032 0.9253
Schistosoma mansoni rab6-interacting 0.0063 0.1035 0.1164
Leishmania major glucose transporter, lmgt3 0.0033 0.0345 0.09
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0307 0.6681 0.846
Leishmania major cytochrome p450-like protein 0.0047 0.0665 0.225
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0359 0.789 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0345 0.086
Echinococcus granulosus lipoxygenase domain containing protein 0.0063 0.1035 0.1268
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0119 0.234 0.932
Schistosoma mansoni aldehyde dehydrogenase 0.0126 0.2501 0.3054
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.032 0.0358
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0047 0.0665 0.225
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0047 0.0665 0.2511
Loa Loa (eye worm) sugar transporter 0.0106 0.2038 0.2457
Brugia malayi Doublecortin family protein 0.0063 0.1035 0.1164
Loa Loa (eye worm) cytochrome P450 family protein 0.0144 0.2919 0.3593
Loa Loa (eye worm) hypothetical protein 0.0026 0.0182 0.0065
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0047 0.0665 0.225
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.0345 0.09
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0047 0.0665 0.225
Brugia malayi Sugar transporter family protein 0.0106 0.2038 0.2457
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0131 0.2611 1
Toxoplasma gondii aldehyde dehydrogenase 0.0126 0.2501 0.371
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0047 0.0665 0.225
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0047 0.0665 0.2511
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0047 0.0665 0.2511
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0047 0.0665 0.225
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0047 0.0665 0.225
Echinococcus granulosus lysyl tRNA synthetase 0.0024 0.0132 0.0118
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0345 0.1423
Echinococcus multilocularis sodium channel protein 0.0137 0.2764 0.3472
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0289 0.0318
Trypanosoma brucei glucose transporter, putative 0.0033 0.0345 0.086
Toxoplasma gondii hypothetical protein 0.0036 0.0411 0.0437
Mycobacterium ulcerans aldehyde dehydrogenase 0.0126 0.2501 1
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0047 0.0665 0.2511
Schistosoma mansoni protein kinase 0.0032 0.0335 0.0263
Loa Loa (eye worm) hypothetical protein 0.0032 0.032 0.0243
Toxoplasma gondii transporter, cation channel family protein 0.0053 0.0819 0.1077
Trypanosoma brucei glucose transporter 1E 0.0033 0.0345 0.086
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.2038 0.2546
Schistosoma mansoni glucose transport protein 0.0106 0.2038 0.2457
Trypanosoma brucei glucose transporter, putative 0.0033 0.0345 0.086
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0345 0.1423
Schistosoma mansoni rab6-interacting 0.0063 0.1035 0.1164
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0047 0.0665 0.2511
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0047 0.0665 0.2546
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0335 0.0378
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0047 0.0665 0.225
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0047 0.0665 0.225
Schistosoma mansoni lipoxygenase 0.0194 0.4069 0.5075
Mycobacterium ulcerans aldehyde dehydrogenase 0.0126 0.2501 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0119 0.234 0.932
Loa Loa (eye worm) voltage-dependent calcium channel 0.0053 0.0819 0.0886
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0119 0.234 0.2846
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0442 0.1252
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.032 0.0243
Mycobacterium ulcerans putative regulatory protein 0.0039 0.0492 0.1521
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0111 0.2154 0.2607
Trypanosoma brucei glucose transporter, putative 0.0033 0.0345 0.086
Echinococcus multilocularis transfer RNA-Lys 0.0039 0.0492 0.0577
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0047 0.0665 0.225
Entamoeba histolytica protein kinase, putative 0.0032 0.0335 1
Schistosoma mansoni protein kinase 0.0032 0.0335 0.0263
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0335 0.0378
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0119 0.234 0.2931
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0047 0.0665 0.225
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0047 0.0665 0.2511
Loa Loa (eye worm) cytochrome P450 0.0047 0.0665 0.0687
Plasmodium falciparum calcium-dependent protein kinase 2 0.0033 0.0336 0.0207
Brugia malayi Cytochrome P450 family protein 0.0056 0.0886 0.0972
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.032 0.0243
Toxoplasma gondii cytochrome p450 superfamily protein 0.0047 0.0665 0.0835
Brugia malayi PAS domain containing protein 0.0053 0.0811 0.0875
Brugia malayi hypothetical protein 0.0063 0.1035 0.1164
Echinococcus granulosus single minded 2 0.0039 0.0492 0.0577
Trypanosoma brucei cytochrome P450, putative 0.0056 0.0886 0.3041
Brugia malayi Cytochrome P450 family protein 0.0056 0.0886 0.0972
Trypanosoma brucei glucose transporter, putative 0.0033 0.0345 0.086
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0047 0.0665 0.2546
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0345 0.1423
Mycobacterium leprae Conserved hypothetical protein 0.0047 0.0665 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0411 0.036
Schistosoma mansoni polycystin 1-related 0.0063 0.1035 0.1164
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0307 0.6681 0.846
Echinococcus granulosus lipoxygenase domain containing protein 0.0063 0.1035 0.1268
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0047 0.0665 0.225
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0335 0.1374
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0047 0.0665 0.2546
Schistosoma mansoni hypothetical protein 0.0106 0.2038 0.2457
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0335 0.0263
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0126 0.2501 0.3136
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0047 0.0665 0.2511
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0335 0.0378
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0345 0.086
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0345 0.1321
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0289 0.0318
Loa Loa (eye worm) cytochrome P450 family protein 0.0056 0.0886 0.0972
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0335 0.0378
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0131 0.2611 1
Plasmodium vivax calcium-dependent protein kinase, putative 0.0033 0.0336 0.0207
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.032 0.0243
Plasmodium falciparum protein kinase 7 0.03 0.6518 0.6471
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0359 0.789 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.2038 0.2546
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0126 0.2501 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0033 0.0336 0.032
Trypanosoma brucei glucose transporter, putative 0.0033 0.0345 0.086
Mycobacterium ulcerans aldehyde dehydrogenase 0.0126 0.2501 1
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0119 0.234 0.2931
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0126 0.2501 1
Loa Loa (eye worm) calcium channel 0.0359 0.789 1
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0359 0.789 1
Schistosoma mansoni protein kinase 0.0032 0.0335 0.0263
Trypanosoma cruzi cytochrome P450, putative 0.0056 0.0886 0.3392
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0359 0.789 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.2038 0.2546
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0037 0.0442 0.0486
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.032 1
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0345 0.1423
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0137 0.2764 0.3472
Echinococcus multilocularis 0.0047 0.0665 0.0797
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0047 0.0665 0.2511
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0359 0.789 1
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0106 0.2038 0.2546
Plasmodium falciparum calcium-dependent protein kinase 1 0.0033 0.0336 0.0207
Leishmania major protein kinase, putative 0.0032 0.0335 0.086
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0047 0.0665 0.225
Onchocerca volvulus 0.0063 0.1035 1
Toxoplasma gondii facilitative glucose transporter GT1 0.0106 0.2038 0.2985
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0047 0.0665 0.2511
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0335 0.0378
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0359 0.789 1
Plasmodium falciparum hexose transporter 0.0106 0.2038 0.1932
Schistosoma mansoni glucose transport protein 0.0106 0.2038 0.2457
Brugia malayi Cytochrome P450 family protein 0.0047 0.0665 0.0687
Leishmania major glucose transporter, lmgt1 0.0033 0.0345 0.09
Echinococcus granulosus General substrate transporter 0.0091 0.1693 0.2107
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0047 0.0665 0.225
Brugia malayi Cam kinase protein 1 0.0032 0.0335 0.0263
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0335 0.0821
Mycobacterium leprae putative cytochrome p450 0.0047 0.0665 1
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.032 0.4403
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0047 0.0665 0.225
Trypanosoma cruzi cytochrome P450, putative 0.0056 0.0886 0.3392
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0126 0.2501 0.3136
Echinococcus multilocularis voltage dependent calcium channel 0.0359 0.789 1
Entamoeba histolytica protein kinase, putative 0.0032 0.0335 1
Brugia malayi follicle stimulating hormone receptor 0.0232 0.4945 0.6204
Schistosoma mansoni lipoxygenase 0.0307 0.6681 0.8441
Loa Loa (eye worm) hypothetical protein 0.0053 0.0819 0.0886
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0119 0.234 0.2846
Schistosoma mansoni cytochrome P450 0.0047 0.0665 0.0687
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0047 0.0665 0.2511
Loa Loa (eye worm) CYP4Cod1 0.0056 0.0886 0.0972
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0335 0.0263
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0442 0.131
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.0132 0.1341
Leishmania major glucose transporter, lmgt2 0.0033 0.0345 0.09
Brugia malayi Cytochrome P450 family protein 0.0144 0.2919 0.3593
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0442 0.1693
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0335 0.0378
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0047 0.0665 0.215
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0232 0.4945 0.6204
Trichomonas vaginalis conserved hypothetical protein 0.0106 0.2038 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0063 0.1035 0.1268
Echinococcus multilocularis lipoxygenase domain containing protein 0.0063 0.1035 0.1268
Brugia malayi hypothetical protein 0.0063 0.1035 0.1164
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0056 0.0886 0.3183
Echinococcus granulosus sodium channel protein 0.006 0.0972 0.1189
Loa Loa (eye worm) hypoxia-induced factor 1 0.0164 0.3381 0.4188
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.2038 0.2546
Echinococcus granulosus RUN 0.0063 0.1035 0.1268
Leishmania major calcium channel protein, putative,ion transporter, putative 0.006 0.0972 0.3548
Schistosoma mansoni single-minded 0.0053 0.0811 0.0875

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 7.5376 Inhibition of NaV1.7 ion channel (unknown origin) ChEMBL. 23177785

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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