TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 540.636 | Formula: C29H28N6O3S
H donors: 2 H acceptors: 6 LogP: 2.14 Rotable bonds: 7
Rule of 5 violations (Lipinski): 2
SMILES: O=c1c2cc(ccc2ccc2c1cc(cn2)c1cnn(c1)C1CCNCC1)CS(=O)(=O)NCc1ccccn1
InChi: 1S/C29H28N6O3S/c36-29-26-13-20(19-39(37,38)34-17-24-3-1-2-10-31-24)4-5-21(26)6-7-28-27(29)14-22(15-32-28)23-16-33-35(18-23)25-8-11-30-12-9-25/h1-7,10,13-16,18,25,30,34H,8-9,11-12,17,19H2
InChiKey: GVFOWLBJJRVCFI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	MET proto-oncogene, receptor tyrosine kinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0084	0.0734	0.1246
Leishmania major	ATP-binding cassette protein subfamily B, member 2, putative	0.0062	0.0494	0.0959
Trichomonas vaginalis	penicillin-binding protein, putative	0.0084	0.0734	0.2208
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0023	0.0057	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0347	0.1049
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	0.0062	0.0494	0.5
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0062	0.0494	0.0599
Brugia malayi	ecdysteroid receptor	0.0023	0.0057	0.0172
Echinococcus multilocularis	microtubule associated protein 2	0.075	0.8211	0.9947
Mycobacterium tuberculosis	Bacterioferritin BfrB	0.002	0.0014	0.0002
Brugia malayi	multidrug resistance protein 3	0.0062	0.0494	0.1496
Brugia malayi	Latrophilin receptor protein 2	0.0053	0.0391	0.1183
Brugia malayi	Ets-domain containing protein	0.0083	0.0724	0.2191
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0023	0.0057	0.0172
Schistosoma mansoni	thyroid hormone receptor	0.0315	0.333	0.4056
Entamoeba histolytica	P-glyco protein 6, putative	0.0062	0.0494	0.0489
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0023	0.0057	0.0069
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0014	0.0027
Leishmania major	cathepsin L-like protease	0.002	0.0014	0.0002
Brugia malayi	Phosphatidylcholine:ceramide cholinephosphotransferase 3	0.0049	0.0347	0.1049
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0014	0.0027
Trypanosoma cruzi	cysteine peptidase, putative	0.002	0.0014	0.0002
Schistosoma mansoni	ferritin	0.002	0.0014	0.0018
Leishmania major	p-glycoprotein	0.0062	0.0494	0.0959
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0292	0.3068	0.3716
Schistosoma mansoni	multidrug resistance protein	0.0062	0.0494	0.0602
Loa Loa (eye worm)	glutaminase	0.0313	0.3304	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0023	0.0057	0.0172
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0315	0.333	0.4035
Brugia malayi	MH2 domain containing protein	0.0269	0.2818	0.8527
Schistosoma mansoni	cathepsin F (C01 family)	0.002	0.0014	0.0018
Trypanosoma cruzi	hypothetical protein, conserved	0.0084	0.0734	0.1436
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0075	0.0634	0.1237
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0014	0.0027
Brugia malayi	hypothetical protein	0.0085	0.0743	0.2249
Trichomonas vaginalis	ABC transporter, putative	0.0062	0.0494	0.1482
Loa Loa (eye worm)	multidrug resistance protein 3	0.0062	0.0494	0.1496
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0023	0.0057	0.0172
Mycobacterium leprae	PROBABLE BACTERIOFERRITIN BFRA	0.002	0.0014	0.0018
Schistosoma mansoni	multidrug resistance protein	0.0062	0.0494	0.0602
Brugia malayi	nuclear receptor NHR-88	0.0023	0.0057	0.0172
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0062	0.0494	0.1482
Trichomonas vaginalis	abcb9, putative	0.0062	0.0494	0.1482
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0014	0.0027
Trypanosoma brucei	sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional	0.0467	0.5032	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0062	0.0494	0.1482
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0062	0.0494	0.1482
Mycobacterium tuberculosis	Conserved protein	0.0084	0.0734	0.1246
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.002	0.0014	0.0027
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0023	0.0057	0.0069
Treponema pallidum	bacterioferrin (TpF1)	0.002	0.0014	0.5
Mycobacterium ulcerans	bacterioferritin BfrB	0.002	0.0014	0.0004
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0062	0.0494	0.6679
Echinococcus granulosus	ATP binding cassette sub family B	0.002	0.0013	0.0016
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0023	0.0057	0.0069
Entamoeba histolytica	P-glycoprotein-2	0.0062	0.0494	0.0489
Echinococcus multilocularis		0.002	0.0013	0.0016
Toxoplasma gondii	ATP-binding cassette transporter ABC.B1	0.0062	0.0494	0.6679
Entamoeba histolytica	hypothetical protein	0.0049	0.0347	0.0341
Echinococcus granulosus	multidrug resistance protein 1	0.0044	0.0283	0.0343
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0487	0.1473
Schistosoma mansoni	apoferritin-2	0.002	0.0014	0.0018
Loa Loa (eye worm)	fibroinase	0.002	0.0014	0.0044
Trichomonas vaginalis	abcb9, putative	0.0062	0.0494	0.1482
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0023	0.0057	0.0172
Trichomonas vaginalis	taga, putative	0.0062	0.0494	0.1482
Schistosoma mansoni	glutaminase	0.0313	0.3304	0.4024
Entamoeba histolytica	hypothetical protein	0.0085	0.0743	0.0738
Mycobacterium tuberculosis	Probable bacterioferritin BfrA	0.002	0.0014	0.0002
Echinococcus granulosus	ferritin	0.002	0.0014	0.0017
Entamoeba histolytica	P-glycoprotein-1	0.0062	0.0494	0.0489
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0734	0.2221
Loa Loa (eye worm)	hypothetical protein	0.002	0.0013	0.004
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0062	0.0494	0.1482
Onchocerca volvulus	Bile acid receptor homolog	0.0023	0.0057	0.0417
Plasmodium falciparum	sphingomyelin synthase 1, putative	0.0049	0.0347	0.6929
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0006	0.0017
Trichomonas vaginalis	D-aminoacylase, putative	0.0084	0.0734	0.2208
Plasmodium vivax	hypothetical protein, conserved	0.0084	0.0734	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0014	0.0027
Leishmania major	cathepsin L-like protease	0.0075	0.0634	0.1237
Brugia malayi	Ets-domain containing protein	0.0083	0.0724	0.2191
Schistosoma mansoni	cathepsin F (C01 family)	0.002	0.0014	0.0018
Onchocerca volvulus		0.011	0.1032	1
Plasmodium falciparum	sphingomyelin synthase 2, putative	0.0049	0.0347	0.6929
Entamoeba histolytica	hypothetical protein	0.0085	0.0743	0.0738
Brugia malayi	ABC transporter	0.002	0.0013	0.004
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0023	0.0057	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0057	0.0172
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0014	0.0027
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0062	0.0494	0.1482
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0014	0.0027
Schistosoma mansoni	multidrug resistance protein	0.002	0.0013	0.0016
Echinococcus multilocularis	ATP binding cassette sub family B	0.0062	0.0487	0.059
Echinococcus multilocularis	cathepsin L cysteine protease	0.002	0.0014	0.0017
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0062	0.0494	0.1482
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0168	0.1681	0.5086
Entamoeba histolytica	P-glycoprotein-2, putative	0.0062	0.0494	0.0489
Trichomonas vaginalis	sphingomyelin synthetase, putative	0.0049	0.0347	0.1034
Brugia malayi	latrophilin 2 splice variant baaae	0.0115	0.1084	0.328
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0057	0.0172
Entamoeba histolytica	ABC transporter, putative	0.002	0.0013	0.0008
Trypanosoma cruzi	major cysteine proteinase, putative	0.0059	0.0454	0.0878
Echinococcus multilocularis	multidrug resistance associated protein 7	0.002	0.0013	0.0016
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0014	0.0027
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0062	0.0494	0.0599
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0075	0.0634	0.1237
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0075	0.0634	0.1237
Giardia lamblia	ABC transporter, putative	0.002	0.0013	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0053	0.0391	0.1183
Entamoeba histolytica	hypothetical protein	0.0049	0.0347	0.0341
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0062	0.0494	0.0599
Trypanosoma brucei	sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional	0.0467	0.5032	1
Schistosoma mansoni	spingomyelin synthetase-related	0.0049	0.0347	0.0422
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0023	0.0057	0.0172
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0014	0.0027
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0062	0.0494	0.1482
Loa Loa (eye worm)	hypothetical protein	0.011	0.1032	0.3124
Brugia malayi	beta-lactamase	0.0084	0.0734	0.2221
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0014	0.0027
Schistosoma mansoni	hypothetical protein	0.0085	0.0743	0.0905
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0062	0.0494	0.1482
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0734	0.2221
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0014	0.0027
Loa Loa (eye worm)	ctsf protein	0.002	0.0014	0.0044
Trypanosoma brucei	ceramide phosphorylethanolamine synthase	0.0049	0.0347	0.0665
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0053	0.0391	0.0474
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0023	0.0057	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0494	0.1496
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0734	0.2221
Brugia malayi	ABC transporter family protein	0.002	0.0013	0.004
Trichomonas vaginalis	conserved hypothetical protein	0.0049	0.0347	0.1034
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0023	0.0057	0.0069
Schistosoma mansoni	multidrug resistance protein	0.0019	0.0006	0.0007
Schistosoma mansoni	retinoic acid receptor RXR	0.0023	0.0057	0.0069
Echinococcus multilocularis	tumor protein p63	0.0754	0.8254	1
Schistosoma mansoni	hypothetical protein	0.0053	0.0391	0.0476
Trypanosoma cruzi	sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional	0.0467	0.5032	1
Mycobacterium leprae	conserved hypothetical protein	0.0084	0.0734	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.002	0.0014	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0589	0.1783
Echinococcus granulosus	multidrug resistance protein 1	0.0062	0.0494	0.0599
Entamoeba histolytica	ATP-binding cassette protein, putative	0.002	0.0013	0.0008
Echinococcus granulosus	ATP binding cassette sub family B	0.002	0.0013	0.0016
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0023	0.0057	0.0172
Trypanosoma brucei	inositol phosphorylceramide synthase	0.0049	0.0347	0.0665
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0023	0.0057	0.0172
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0023	0.0057	0.0172
Entamoeba histolytica	ATP-binding cassette protein, putative	0.002	0.0013	0.0008
Trichomonas vaginalis	D-aminoacylase, putative	0.0084	0.0734	0.2208
Loa Loa (eye worm)	hypothetical protein	0.002	0.0013	0.004
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0075	0.0634	0.1237
Loa Loa (eye worm)	fli-1 protein	0.0251	0.2617	0.7921
Schistosoma mansoni	coup transcription factor	0.0023	0.0057	0.0069
Schistosoma mansoni	smdr2	0.0062	0.0494	0.0602
Echinococcus granulosus	FTZ F1 alpha	0.0023	0.0057	0.0069
Trichomonas vaginalis	abcb9, putative	0.0062	0.0494	0.1482
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0023	0.0057	0.0417
Schistosoma mansoni	gabp alpha	0.0083	0.0724	0.0882
Brugia malayi	Nuclear hormone receptor-like 1	0.0023	0.0057	0.0172
Echinococcus multilocularis	ATP binding cassette sub family B	0.002	0.0013	0.0016
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.002	0.0014	0.0026
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0023	0.0057	0.0069
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0014	0.0027
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0023	0.0057	0.0069
Mycobacterium tuberculosis	Probable lipase LipD	0.0084	0.0734	0.1246
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0014	0.0027
Schistosoma mansoni	multidrug resistance protein	0.002	0.0013	0.0016
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0023	0.0057	0.0069
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0083	0.0724	0.2191
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0085	0.0743	0.09
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0062	0.0494	0.1482
Echinococcus multilocularis	cysteine protease	0.002	0.0014	0.0017
Loa Loa (eye worm)	cysteine protease	0.002	0.0014	0.0044
Trichomonas vaginalis	glutaminase, putative	0.0313	0.3304	1
Entamoeba histolytica	P-glycoprotein 5, putative	0.0062	0.0494	0.0489
Onchocerca volvulus		0.0021	0.0028	0.0136
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0023	0.0057	0.0172
Loa Loa (eye worm)	plexin A	0.0025	0.0071	0.0215
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0075	0.0634	0.1237
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0084	0.0734	0.2221
Schistosoma mansoni	hypothetical protein	0.0053	0.0391	0.0476
Echinococcus granulosus	tumor protein p63	0.0754	0.8254	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0075	0.0634	0.1237
Schistosoma mansoni	multidrug resistance protein	0.0062	0.0494	0.0602
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0062	0.0494	0.1482
Trichomonas vaginalis	ABC transporter, putative	0.0062	0.0494	0.1482
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0068	0.0561	0.1091
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0014	0.0027
Echinococcus granulosus	sphingomyelin synthase protein 1	0.0049	0.0347	0.042
Trypanosoma cruzi	cruzipain precursor, putative	0.0075	0.0634	0.1237
Loa Loa (eye worm)	ABC transporter	0.002	0.0013	0.004
Schistosoma mansoni	nuclear hormone receptor	0.0023	0.0057	0.0069
Mycobacterium tuberculosis	Probable hydrolase	0.0084	0.0734	0.1246
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0023	0.0057	0.0172
Brugia malayi	ABC transporter family protein	0.0062	0.0494	0.1496
Brugia malayi	ABC transporter transmembrane region family protein	0.002	0.0013	0.004
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0084	0.0734	0.1246
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0014	0.0027
Schistosoma mansoni	smdr1	0.002	0.0013	0.0016
Brugia malayi	Sphingomyelin synthase-related 1	0.0049	0.0347	0.1049
Entamoeba histolytica	P-glycoprotein-2	0.0062	0.0494	0.0489
Schistosoma mansoni	multidrug resistance protein	0.002	0.0013	0.0016
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	0.0062	0.0494	0.1496
Leishmania major	cathepsin L-like protease	0.002	0.0014	0.0002
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0075	0.0634	0.1237
Schistosoma mansoni	cellular tumor antigen P53	0.011	0.1032	0.1257
Brugia malayi	plexin A	0.0025	0.0071	0.0215
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0062	0.0494	0.1482
Mycobacterium tuberculosis	Probable lipase LipE	0.0084	0.0734	0.1246
Entamoeba histolytica	cysteine proteinase, putative	0.002	0.0014	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0115	0.1084	0.328
Schistosoma mansoni	transcription factor LCR-F1	0.0085	0.0743	0.0905
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0023	0.0057	0.0069
Leishmania major	cysteine peptidase A (CPA)	0.002	0.0014	0.0002
Leishmania major	cathepsin L-like protease	0.002	0.0014	0.0002
Echinococcus granulosus	multidrug resistance associated protein 7	0.002	0.0013	0.0016
Echinococcus multilocularis	ATP binding cassette sub family B	0.002	0.0013	0.0016
Schistosoma mansoni	thyroid hormone receptor	0.0315	0.333	0.4056
Trichomonas vaginalis	sphingomyelin synthetase, putative	0.0049	0.0347	0.1034
Plasmodium vivax	vivapain-2	0.002	0.0014	0.0017
Entamoeba histolytica	hypothetical protein	0.0049	0.0347	0.0341
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.002	0.0013	0.0023
Echinococcus granulosus	GPCR family 2	0.0053	0.0391	0.0474
Trypanosoma brucei	hypothetical protein, conserved	0.0084	0.0734	0.1436
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0347	0.1049
Leishmania major	cathepsin L-like protease	0.0075	0.0634	0.1237
Entamoeba histolytica	hypothetical protein	0.0085	0.0743	0.0738
Brugia malayi	Cathepsin L-like precursor	0.002	0.0014	0.0044
Trichomonas vaginalis	esterase, putative	0.0084	0.0734	0.2208
Trypanosoma cruzi	cysteine peptidase, putative	0.0075	0.0634	0.1237
Echinococcus multilocularis	cysteine protease	0.002	0.0014	0.0017
Onchocerca volvulus		0.0062	0.0494	0.4716
Brugia malayi	beta-lactamase family protein	0.0084	0.0734	0.2221
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0075	0.0634	0.1237
Schistosoma mansoni	ets-related	0.0251	0.2617	0.3188
Leishmania major	cathepsin L-like protease	0.0075	0.0634	0.1237
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0062	0.0494	0.1482
Brugia malayi	Cathepsin L-like precursor	0.002	0.0014	0.0044
Schistosoma mansoni	hypothetical protein	0.0053	0.0391	0.0476
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0023	0.0057	0.0172
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.002	0.0014	0.0044
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0075	0.0634	0.1237
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0014	0.0027
Schistosoma mansoni	multidrug resistance protein	0.002	0.0013	0.0016
Plasmodium vivax	vivapain-2	0.002	0.0014	0.0017
Brugia malayi	photoreceptor-specific nuclear receptor	0.0023	0.0057	0.0172
Onchocerca volvulus	Protein ultraspiracle homolog	0.0023	0.0057	0.0417
Brugia malayi	beta-lactamase family protein	0.0084	0.0734	0.2221
Leishmania major	cathepsin L-like protease	0.002	0.0014	0.0002
Onchocerca volvulus		0.0084	0.0734	0.7068
Plasmodium falciparum	cysteine proteinase falcipain 3	0.002	0.0014	0.0026
Echinococcus multilocularis	multidrug resistance protein 1	0.0044	0.0283	0.0343
Loa Loa (eye worm)	hypothetical protein	0.002	0.0013	0.004
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0057	0.0172
Echinococcus granulosus	multidrug resistance associated protein 1	0.002	0.0013	0.0016
Brugia malayi	steroid hormone receptor	0.0023	0.0057	0.0172
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0062	0.0494	0.1482
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0347	0.1049
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0734	0.2221
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.002	0.0014	0.0027
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0084	0.0734	0.0889
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0057	0.0172
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0084	0.0734	0.0894
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0062	0.0494	0.1482
Brugia malayi	P-glycoprotein-like protein	0.002	0.0013	0.004
Leishmania major	phosphatidylcholine:ceramide cholinephosphotransferase 2	0.0467	0.5032	1
Trypanosoma cruzi	sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional	0.0467	0.5032	1
Echinococcus multilocularis	multidrug resistance associated protein 1	0.002	0.0013	0.0016
Entamoeba histolytica	P-glycoprotein-5	0.0062	0.0494	0.0489
Echinococcus granulosus	5'partial\|ATP binding cassette sub family B	0.0062	0.0487	0.059
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0053	0.0391	0.0474
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0023	0.0057	0.0069
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.002	0.0014	0.0017
Brugia malayi	nuclear hormone receptor	0.0023	0.0057	0.0172
Onchocerca volvulus		0.0023	0.0057	0.0417
Trichomonas vaginalis	hypothetical protein	0.0049	0.0347	0.1034
Trichomonas vaginalis	ABC transporter, putative	0.0062	0.0494	0.1482
Schistosoma mansoni	ferritin	0.002	0.0014	0.0018
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0062	0.0494	0.1482
Brugia malayi	Cathepsin L-like precursor	0.002	0.0014	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0347	0.1049
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0023	0.0057	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0057	0.0172
Echinococcus multilocularis	cathepsin L cysteine protease	0.002	0.0014	0.0017
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0023	0.0057	0.0172
Mycobacterium ulcerans	hypothetical protein	0.0084	0.0734	0.219
Echinococcus granulosus	expressed protein	0.002	0.0014	0.0017
Toxoplasma gondii	cathepsin CPL	0.002	0.0014	0.0017
Loa Loa (eye worm)	transcription factor SMAD2	0.0269	0.2818	0.8527
Echinococcus multilocularis	GA binding protein alpha chain	0.0083	0.0724	0.0877
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0044	0.0283	0.0841
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0062	0.0494	0.1482
Trichomonas vaginalis	ferritin, putative	0.002	0.0014	0.0027
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0062	0.0494	0.0599
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.002	0.0014	0.0017
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0292	0.3068	0.3716
Giardia lamblia	MRP-like ABC transporter	0.002	0.0013	1
Brugia malayi	Papain family cysteine protease containing protein	0.002	0.0014	0.0044
Brugia malayi	Cathepsin L-like precursor	0.002	0.0014	0.0044
Entamoeba histolytica	P-glycoprotein 6, putative	0.002	0.0013	0.0008
Loa Loa (eye worm)	ABC transporter transmembrane region family protein	0.002	0.0013	0.004
Brugia malayi	ABC transporter family protein	0.002	0.0013	0.004
Brugia malayi	Steroid receptor seven-up type 2	0.0023	0.0057	0.0172
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0023	0.0057	0.0069
Echinococcus granulosus	multidrug resistance protein 1	0.0062	0.0494	0.0599
Echinococcus multilocularis	ferritin	0.002	0.0014	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0028	0.0085
Schistosoma mansoni	hypothetical protein	0.0292	0.3068	0.3736
Brugia malayi	Phosphatidylcholine:ceramide cholinephosphotransferase 2	0.0049	0.0347	0.1049
Schistosoma mansoni	multidrug resistance protein	0.002	0.0013	0.0016
Brugia malayi	Phosphatidylcholine:ceramide cholinephosphotransferase 1	0.0049	0.0347	0.1049
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0062	0.0494	0.0599
Schistosoma mansoni	ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6)	0.0019	0.0006	0.0007
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0023	0.0057	0.0172
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0014	0.0027
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0084	0.0734	0.0894
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0062	0.0494	0.0599
Trypanosoma cruzi	hypothetical protein, conserved	0.0084	0.0734	0.1436
Toxoplasma gondii	ABC1 family protein	0.0084	0.0734	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.0023	0.0057	0.0069
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0023	0.0057	0.0172
Entamoeba histolytica	hypothetical protein	0.0085	0.0743	0.0738
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0062	0.0494	0.1482
Entamoeba histolytica	hypothetical protein	0.0049	0.0347	0.0341
Loa Loa (eye worm)	hypothetical protein	0.0168	0.1681	0.5086
Trypanosoma cruzi	cysteine peptidase, putative	0.0075	0.0634	0.1237
Entamoeba histolytica	ATP-binding cassette protein, putative	0.002	0.0013	0.0008
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0023	0.0057	0.0069
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0014	0.0027
Onchocerca volvulus		0.0084	0.0734	0.7068
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0023	0.0057	0.0172
Echinococcus granulosus	beta LACTamase domain containing family member	0.0084	0.0734	0.0889
Mycobacterium ulcerans	beta-lactamase	0.0084	0.0734	0.219
Entamoeba histolytica	P-glycoprotein 6, putative	0.002	0.0013	0.0008
Echinococcus multilocularis	expressed protein	0.002	0.0014	0.0017
Loa Loa (eye worm)	ABC transporter	0.002	0.0013	0.004
Echinococcus multilocularis	FTZ F1 alpha	0.0023	0.0057	0.0069
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0023	0.0057	0.0069
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0084	0.0734	0.1246
Mycobacterium tuberculosis	Probable transmembrane multidrug efflux pump	0.0062	0.0494	0.0832
Echinococcus multilocularis	ATP binding cassette sub family B	0.002	0.0013	0.0016
Echinococcus multilocularis	ATP binding cassette sub family B	0.002	0.0013	0.0016
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0062	0.0494	0.0599
Loa Loa (eye worm)	ABC transporter	0.002	0.0013	0.004
Brugia malayi	Phosphatidylcholine:ceramide cholinephosphotransferase 2	0.0049	0.0347	0.1049
Echinococcus granulosus	GA binding protein alpha chain	0.0083	0.0724	0.0877
Leishmania major	cathepsin L-like protease	0.002	0.0014	0.0002
Mycobacterium ulcerans	bacterioferritin BfrA	0.002	0.0014	0.0004
Trichomonas vaginalis	penicillin-binding protein, putative	0.0084	0.0734	0.2208
Trichomonas vaginalis	sphingomyelin synthetase, putative	0.0049	0.0347	0.1034
Plasmodium vivax	sphingomyelin synthase 1, putative	0.0049	0.0347	0.4628
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0057	0.0172
Brugia malayi	Cathepsin L-like precursor	0.002	0.0014	0.0044
Trichomonas vaginalis	D-aminoacylase, putative	0.0084	0.0734	0.2208
Brugia malayi	hypothetical protein	0.002	0.0013	0.004
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0062	0.0494	0.1482
Loa Loa (eye worm)	MH2 domain-containing protein	0.0269	0.2818	0.8527
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0347	0.1049
Echinococcus granulosus	plexin a4	0.0025	0.0071	0.0086
Brugia malayi	ABC transporter transmembrane region family protein	0.002	0.0013	0.004
Loa Loa (eye worm)	hypothetical protein	0.002	0.0014	0.0044
Mycobacterium leprae	Probable lipase LipE	0.0084	0.0734	1
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0734	0.2221
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0014	0.0027
Loa Loa (eye worm)	glutaminase 2	0.0313	0.3304	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0535	0.5798	1
Entamoeba histolytica	cysteine proteinase, putative	0.002	0.0014	0.0009
Echinococcus granulosus	cathepsin l1	0.002	0.0014	0.0017
Schistosoma mansoni	apoferritin-2	0.002	0.0014	0.0018
Giardia lamblia	Multidrug resistance-associated protein 1	0.002	0.0013	1
Brugia malayi	ABC transporter family protein	0.002	0.0013	0.004
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0023	0.0057	0.0172
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0023	0.0057	0.0172
Brugia malayi	Cathepsin L-like precursor	0.002	0.0014	0.0044
Wolbachia endosymbiont of Brugia malayi	bacterioferritin/cytochrome b1	0.002	0.0014	1
Mycobacterium ulcerans	esterase/lipase LipP	0.0084	0.0734	0.219
Plasmodium falciparum	multidrug resistance protein 1	0.0062	0.0494	1
Entamoeba histolytica	multidrug resistance protein, putative	0.002	0.0013	0.0008
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0168	0.1681	0.5086
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0075	0.0634	0.1237
Schistosoma mansoni	plexin	0.0021	0.0028	0.0034
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0023	0.0057	0.0069
Giardia lamblia	Multidrug resistance-associated protein 1	0.002	0.0013	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0023	0.0057	0.0172
Echinococcus granulosus	multidrug resistance protein 1	0.0044	0.0283	0.0343
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0057	0.0172
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0062	0.0494	0.0599
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0014	0.0027
Brugia malayi	ABC transporter transmembrane region family protein	0.0019	0.0006	0.0017
Brugia malayi	Phosphatidylcholine:ceramide cholinephosphotransferase 1	0.0049	0.0347	0.1049
Toxoplasma gondii	hypothetical protein	0.0049	0.0347	0.4628
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0062	0.0494	0.1482
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0023	0.0057	0.0069
Schistosoma mansoni	ferritin light chain	0.002	0.0014	0.0018
Trichomonas vaginalis	sphingomyelin synthetase, putative	0.0049	0.0347	0.1034
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0084	0.0734	0.2221
Echinococcus granulosus	microtubule associated protein 2	0.075	0.8211	0.9947
Mycobacterium ulcerans	glutaminase	0.0313	0.3304	1
Brugia malayi	ABC transporter	0.0019	0.0006	0.0017
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0085	0.0743	0.09
Plasmodium falciparum	sphingomyelin synthase 1, putative	0.0049	0.0347	0.6929
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0084	0.0734	0.219
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0734	0.2221
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0347	0.1049
Brugia malayi	multidrug Resistance Protein family member (mrp-5), putative	0.002	0.0013	0.004
Brugia malayi	multidrug resistance related protein 1	0.002	0.0013	0.004
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.002	0.0014	0.0044
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0014	0.0027
Schistosoma mansoni	microtubule-associated protein tau	0.075	0.8211	1
Echinococcus granulosus	ATP binding cassette sub family B	0.0019	0.0006	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0391	0.1183
Brugia malayi	Plexin repeat family protein	0.0021	0.0028	0.0085
Schistosoma mansoni	hypothetical protein	0.0053	0.0391	0.0476
Echinococcus multilocularis	plexin a4	0.0025	0.0071	0.0086
Schistosoma mansoni	ferritin	0.002	0.0014	0.0018
Entamoeba histolytica	hypothetical protein	0.002	0.0013	0.0008
Mycobacterium tuberculosis	Conserved protein	0.0084	0.0734	0.1246
Echinococcus multilocularis	GPCR, family 2	0.0053	0.0391	0.0474
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0075	0.0634	0.1237
Echinococcus multilocularis	multidrug resistance protein 1	0.0062	0.0494	0.0599
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0006	0.0017
Loa Loa (eye worm)	steroid hormone receptor	0.0023	0.0057	0.0172
Mycobacterium tuberculosis	Probable esterase LipL	0.0084	0.0734	0.1246
Leishmania major	hypothetical protein, conserved	0.0084	0.0734	0.1436
Schistosoma mansoni	ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7)	0.002	0.0013	0.0016
Brugia malayi	glutaminase DH11.1	0.0313	0.3304	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0023	0.0057	0.0069
Echinococcus granulosus	multidrug resistance protein 1	0.0062	0.0494	0.0599
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0494	0.1496
Schistosoma mansoni	RAR-like nuclear receptor	0.0023	0.0057	0.0069
Echinococcus multilocularis	multidrug resistance protein 1	0.0062	0.0494	0.0599
Trypanosoma cruzi	cysteine peptidase, putative	0.0075	0.0634	0.1237
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0062	0.0494	0.1482
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0168	0.1681	0.5086
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0057	0.0172
Entamoeba histolytica	hypothetical protein	0.0049	0.0347	0.0341
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0023	0.0057	0.0172
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0023	0.0057	0.0172
Echinococcus granulosus	ecdysone induced protein 78C	0.0023	0.0057	0.0069
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0053	0.0391	0.1183
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0062	0.0494	0.1482
Entamoeba histolytica	ATP-binding cassette protein, putative	0.002	0.0013	0.0008
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0062	0.0494	0.1482
Trichomonas vaginalis	ABC transporter, putative	0.0062	0.0494	0.1482
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0062	0.0494	0.0599
Entamoeba histolytica	cysteine protease, putative	0.002	0.0014	0.0009
Echinococcus multilocularis	sphingomyelin synthase protein 1	0.0049	0.0347	0.042
Schistosoma mansoni	ferritin light chain	0.002	0.0014	0.0018
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0053	0.0391	0.0474
Mycobacterium tuberculosis	Conserved protein	0.0084	0.0734	0.1246
Mycobacterium ulcerans	lipase LipD	0.0084	0.0734	0.219
Plasmodium vivax	sphingomyelin synthase 2, putative	0.0049	0.0347	0.4628
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0014	0.0027
Plasmodium vivax	multidrug resistance protein 1, putative	0.0062	0.0494	0.6679
Schistosoma mansoni	hypothetical protein	0.0115	0.1084	0.132
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0014	0.0027
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0023	0.0057	0.0069
Echinococcus granulosus	cathepsin l cysteine peptidase	0.002	0.0014	0.0017
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.002	0.0014	0.0026
Loa Loa (eye worm)	beta-lactamase	0.0084	0.0734	0.2221
Schistosoma mansoni	ferritin	0.002	0.0014	0.0018
Entamoeba histolytica	hypothetical membrane-spanning protein	0.0049	0.0347	0.0341
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0053	0.0391	0.0474
Onchocerca volvulus		0.0084	0.0734	0.7068
Brugia malayi	Fli-1 protein	0.0251	0.2617	0.7921

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1 nM	Inhibition of c-MET (unknown origin)-catalyzed N-biotinylated EQEDEPEGDYFEWLECONH2 phosphorylation by TR-FRET assay	ChEMBL.	23379595

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2323783

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1726811