TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 348.387 | Formula: C19H22F2N2O2
H donors: 1 H acceptors: 1 LogP: 3.11 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O[C@@H](CN1CCN(CC1)c1ccc(cc1)F)COc1ccc(cc1)F
InChi: 1S/C19H22F2N2O2/c20-15-1-5-17(6-2-15)23-11-9-22(10-12-23)13-18(24)14-25-19-7-3-16(21)4-8-19/h1-8,18,24H,9-14H2/t18-/m0/s1
InChiKey: LWUXYBCYDPOVBW-SFHVURJKSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.001	0.0006	0.0006
Brugia malayi	major facilitator superfamily protein	0.0014	0.0097	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0097	0.0097
Schistosoma mansoni	neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule	0.0017	0.016	0.0186
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0463	0.0537
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0031	0.0439	0.0509
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0031	0.0439	0.0465
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0019	0.0201	0.1293
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0186	0.0186
Schistosoma mansoni	nAChR subunit	0.0019	0.0186	0.0215
Brugia malayi	hypothetical protein	0.0031	0.0439	0.0439
Trichomonas vaginalis	CMGC family protein kinase	0.0052	0.09	0.4348
Brugia malayi	tailless protein	0.0031	0.0439	0.0439
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0462	0.4537
Echinococcus multilocularis	neuroglian	0.0037	0.0584	0.0677
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0052	0.09	0.09
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0019	0.0186	0.0215
Trypanosoma cruzi	ISWI complex protein	0.0016	0.0125	0.035
Brugia malayi	steroid hormone receptor	0.0065	0.116	0.116
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0062	0.111	0.1287
Brugia malayi	nuclear receptor RXR	0.0031	0.0439	0.0439
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0065	0.116	0.116
Schistosoma mansoni	protein kinase	0.0032	0.0463	0.0537
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0052	0.09	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0463	0.0537
Echinococcus multilocularis	hemicentin 1	0.0017	0.016	0.0186
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0201	0.0562
Onchocerca volvulus		0.0014	0.0097	0.0098
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0019	0.0186	0.0186
Brugia malayi	Cation transporter family protein	0.0019	0.0186	0.0186
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0031	0.0439	0.0509
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0462	0.4537
Schistosoma mansoni	thyroid hormone receptor	0.0065	0.116	0.1346
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0019	0.0186	0.0215
Loa Loa (eye worm)	GABA receptor subunit	0.001	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0439	0.0439
Brugia malayi	hypothetical protein	0.0031	0.0439	0.0439
Onchocerca volvulus		0.0014	0.0097	0.0098
Loa Loa (eye worm)	bromodomain containing protein	0.0018	0.0177	0.0177
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0032	0.0463	0.0633
Brugia malayi	orphan nuclear receptor NR2E1	0.0031	0.0439	0.0439
Onchocerca volvulus		0.0029	0.0415	0.0439
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0186	0.0186
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0065	0.116	0.1346
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0097	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0017	0.016	0.016
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0097	0.0097
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0201	0.0118
Brugia malayi	Peroxidasin	0.0017	0.016	0.016
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0019	0.0186	0.0215
Echinococcus multilocularis	glycine receptor subunit beta	0.0019	0.0186	0.0215
Schistosoma mansoni	nephrin	0.0017	0.016	0.0186
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0031	0.0439	0.0509
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0065	0.116	0.116
Brugia malayi	Bromodomain containing protein	0.0039	0.0622	0.0622
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0037	0.0571	0.0662
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0032	0.0463	0.4552
Echinococcus granulosus	glycine receptor subunit beta	0.0019	0.0186	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0463	0.0463
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0019	0.0186	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0065	0.116	0.116
Leishmania major	glucose transporter, lmgt2	0.0032	0.0462	0.4537
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0017	0.0163	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0017	0.016	0.016
Echinococcus granulosus	neuroglian	0.0017	0.016	0.0186
Onchocerca volvulus		0.0014	0.0097	0.0098
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0063	0.1119	0.1298
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0751	0.0751
Echinococcus multilocularis	peroxidasin	0.0017	0.016	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0186	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0097	0.0097
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0065	0.116	0.1346
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0019	0.0186	0.0186
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0097	0.0113
Onchocerca volvulus		0.0014	0.0097	0.0098
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.003	0.0423	0.0491
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0019	0.0186	0.0215
Onchocerca volvulus		0.0019	0.0186	0.0193
Trichomonas vaginalis	CMGC family protein kinase	0.0052	0.09	0.4348
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0052	0.09	1
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0019	0.0186	0.0186
Schistosoma mansoni	serine/threonine protein kinase	0.0052	0.09	0.1044
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0065	0.116	0.116
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0165	0.3277	0.3602
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0065	0.116	0.1346
Brugia malayi	hypothetical protein	0.003	0.0423	0.0423
Loa Loa (eye worm)	hypothetical protein	0.0017	0.016	0.016
Echinococcus granulosus	neuroglian	0.0037	0.0584	0.0677
Onchocerca volvulus		0.0014	0.0097	0.0098
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0019	0.0186	0.0186
Schistosoma mansoni	nuclear receptor	0.0031	0.0439	0.0509
Brugia malayi	MAP kinase sur-1	0.0052	0.09	0.09
Brugia malayi	Sugar transporter family protein	0.0014	0.0097	0.0097
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0032	0.0463	0.0414
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0674	0.0674
Loa Loa (eye worm)	hypothetical protein	0.0155	0.3057	0.3057
Onchocerca volvulus	Putative nachr subunit	0.0019	0.0186	0.0193
Onchocerca volvulus		0.0065	0.116	0.1239
Schistosoma mansoni	roundabout	0.0017	0.016	0.0186
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0019	0.0186	0.0186
Echinococcus granulosus	roundabout 2	0.0017	0.016	0.0186
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0065	0.116	0.1346
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0186	0.0186
Onchocerca volvulus		0.0019	0.0186	0.0193
Giardia lamblia	Prolyl-tRNA synthetase	0.0031	0.044	0.4266
Brugia malayi	nuclear hormone receptor	0.0031	0.0439	0.0439
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0201	0.1293
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0165	0.3277	0.3602
Trypanosoma cruzi	ISWI complex protein	0.0016	0.0125	0.035
Leishmania major	lysyl-tRNA synthetase, putative	0.0023	0.0275	0.2211
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0439	0.0439
Loa Loa (eye worm)	hypothetical protein	0.001	0.0006	0.0006
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0462	0.1973
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0019	0.0186	0.0186
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0018	0.0177	0.0205
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0032	0.0463	0.0463
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0031	0.044	0.044
Schistosoma mansoni	nAChR subunit	0.0019	0.0186	0.0215
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0014	0.0097	0.0113
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0102	0.1944	0.2254
Schistosoma mansoni	tyrosine kinase	0.002	0.0217	0.0252
Chlamydia trachomatis	lysine--tRNA ligase	0.0023	0.0275	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0423	0.0423
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0019	0.0186	0.0215
Schistosoma mansoni	nuclear hormone receptor	0.0065	0.116	0.1346
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0065	0.116	0.1346
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0439	0.0439
Toxoplasma gondii	protein kinase, putative	0.0289	0.5875	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0102	0.1944	0.2254
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0462	0.4537
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0019	0.0186	0.0215
Echinococcus multilocularis	calcium dependent protein kinase	0.0029	0.0412	0.0478
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0019	0.0186	0.0215
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0163	0.0189
Onchocerca volvulus	Bile acid receptor homolog	0.0065	0.116	0.1239
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0014	0.0097	0.2954
Echinococcus granulosus	nAChR subunit	0.001	0.0006	0.0006
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0017	0.016	0.016
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0065	0.116	0.116
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0065	0.116	0.1346
Loa Loa (eye worm)	hypothetical protein	0.0031	0.044	0.044
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0032	0.0463	0.0414
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0275	0.0275
Schistosoma mansoni	protein kinase	0.0032	0.0463	0.0537
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0019	0.0186	0.0215
Brugia malayi	Major Facilitator Superfamily protein	0.0014	0.0097	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0186	0.0186
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.002	0.0211	0.0211
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0019	0.0186	0.0215
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0065	0.116	0.1346
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0186	0.0186
Schistosoma mansoni	cell adhesion molecule	0.0017	0.016	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0439	0.0439
Trichomonas vaginalis	conserved hypothetical protein	0.0102	0.1944	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0102	0.1944	0.2254
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0052	0.09	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0065	0.116	0.116
Onchocerca volvulus	Basement membrane proteoglycan homolog	0.0017	0.016	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0097	0.0097
Onchocerca volvulus		0.0019	0.0186	0.0193
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0201	0.1293
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0025	0.0317	0.0368
Brugia malayi	Nuclear hormone receptor-like 1	0.0034	0.0516	0.0516
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0186	0.0186
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0031	0.0439	0.0465
Brugia malayi	Sugar transporter family protein	0.0014	0.0097	0.0097
Echinococcus granulosus	hemicentin 1	0.0017	0.016	0.0186
Loa Loa (eye worm)	steroid hormone receptor	0.0065	0.116	0.116
Loa Loa (eye worm)	DR-78	0.0031	0.0439	0.0439
Loa Loa (eye worm)	LGC-31 protein	0.0019	0.0186	0.0186
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.001	0.0006	0.0006
Echinococcus granulosus	twitchin	0.004	0.0634	0.0736
Schistosoma mansoni	nAChR subunit	0.0019	0.0186	0.0215
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0019	0.0186	0.0186
Echinococcus granulosus	Immunoglobulin	0.003	0.0423	0.0491
Plasmodium vivax	proline--tRNA ligase, putative	0.0036	0.0547	0.0509
Plasmodium falciparum	lysine--tRNA ligase	0.0023	0.0275	0.0201
Trypanosoma cruzi	hexose transporter	0.0032	0.0462	0.4537
Schistosoma mansoni	protein kinase	0.0032	0.0463	0.0537
Loa Loa (eye worm)	hypothetical protein	0.0017	0.016	0.016
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0032	0.0463	0.0414
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0017	0.016	0.016
Brugia malayi	Major Facilitator Superfamily protein	0.0014	0.0097	0.0097
Onchocerca volvulus		0.0155	0.3057	0.3273
Echinococcus multilocularis	Immunoglobulin	0.003	0.0423	0.0491
Schistosoma mansoni	cpg binding protein	0.0033	0.0492	0.057
Schistosoma mansoni	nuclear hormone receptor	0.0031	0.0439	0.0509
Plasmodium vivax	lysine--tRNA ligase, putative	0.0023	0.0275	0.0201
Echinococcus granulosus	ecdysone induced protein 78C	0.0065	0.116	0.1346
Brugia malayi	Immunoglobulin I-set domain containing protein	0.001	0.0006	0.0006
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0463	0.0537
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0102	0.1944	0.2254
Onchocerca volvulus		0.0014	0.0097	0.0098
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0034	0.0516	0.0599
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0186	0.0186
Onchocerca volvulus	Tyrosine kinase homolog	0.0453	0.9328	1
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0201	0.1293
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0201	0.0233
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0032	0.0463	0.0414
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0165	0.3277	0.5503
Brugia malayi	nuclear receptor NHR-67	0.0031	0.0439	0.0439
Trichomonas vaginalis	CMGC family protein kinase	0.0052	0.09	0.4348
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0019	0.0186	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0097	0.0097
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0031	0.0439	0.0439
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0031	0.044	0.051
Echinococcus granulosus	solute carrier family 22	0.0014	0.0097	0.0113
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0275	1
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0019	0.0186	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0439	0.0439
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0275	1
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0019	0.0186	0.0215
Schistosoma mansoni	nAChR subunit	0.0019	0.0186	0.0215
Echinococcus multilocularis	roundabout 2	0.0047	0.0788	0.0914
Leishmania major	glucose transporter, lmgt1	0.0032	0.0462	0.4537
Echinococcus multilocularis	Immunoglobulin	0.003	0.0423	0.0491
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0463	0.0537
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0014	0.0097	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0186	0.0186
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0462	0.1973
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0623	0.0623
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0065	0.116	0.116
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0516	0.0516
Brugia malayi	major facilitator superfamily protein	0.0014	0.0097	0.0097
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0019	0.0186	0.0186
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0462	0.4537
Brugia malayi	hypothetical protein	0.0034	0.0516	0.0516
Schistosoma mansoni	thyroid hormone receptor	0.0065	0.116	0.1346
Loa Loa (eye worm)	sugar transporter	0.0014	0.0097	0.0097
Loa Loa (eye worm)	TK/ROR protein kinase	0.001	0.0013	0.0013
Trypanosoma brucei	ISWI complex protein	0.0016	0.0125	0.035
Echinococcus granulosus	cpg binding protein	0.0033	0.0492	0.057
Brugia malayi	nuclear hormone receptor family member odr-7	0.0031	0.0439	0.0439
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0065	0.116	0.116
Onchocerca volvulus		0.0014	0.0097	0.0098
Loa Loa (eye worm)	hypothetical protein	0.001	0.0006	0.0006
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0065	0.116	0.1346
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0462	0.4537
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0019	0.0186	0.0186
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0201	0.0562
Schistosoma mansoni	glucose transporter	0.0014	0.0097	0.0113
Echinococcus multilocularis	nAChR subunit	0.0019	0.0186	0.0215
Loa Loa (eye worm)	PHD-finger family protein	0.0021	0.0241	0.0241
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0032	0.0463	0.0633
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.001	0.0006	0.0006
Echinococcus multilocularis	nAChR subunit	0.001	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0439	0.0439
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0014	0.0097	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0516	0.0516
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0462	0.1973
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0065	0.116	0.1346
Entamoeba histolytica	hypothetical protein	0.0023	0.0275	0.5889
Giardia lamblia	Lysyl-tRNA synthetase	0.0023	0.0275	0.2211
Schistosoma mansoni	serine/threonine protein kinase	0.001	0.0006	0.0007
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0019	0.0186	0.0186
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0201	0.0201
Echinococcus multilocularis	roundabout 2	0.0017	0.016	0.0186
Schistosoma mansoni	hypothetical protein	0.0016	0.0125	0.0145
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0201	0.0233
Loa Loa (eye worm)	hypothetical protein	0.004	0.0628	0.0628
Brugia malayi	hypothetical protein	0.0014	0.0097	0.0097
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0201	0.0201
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0065	0.116	0.116
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0019	0.0201	0.4278
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0025	0.0317	0.0368
Schistosoma mansoni	sugar transporter	0.0014	0.0097	0.0113
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0017	0.016	0.016
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0097	0.0113
Entamoeba histolytica	protein kinase, putative	0.0032	0.0463	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0186	0.0186
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0019	0.0186	0.0186
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0017	0.016	0.016
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0186	0.0186
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0019	0.0186	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0439	0.0439
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0017	0.016	0.0186
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0052	0.09	1
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0463	0.0537
Onchocerca volvulus		0.0019	0.0186	0.0193
Schistosoma mansoni	nuclear hormone receptor	0.0031	0.0439	0.0509
Schistosoma mansoni	sugar transporter	0.0014	0.0097	0.0113
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0034	0.0516	0.0599
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.023	0.4631	0.4631
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0065	0.116	0.116
Schistosoma mansoni	hypothetical protein	0.0419	0.8623	1
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0031	0.0439	0.0439
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0462	0.1973
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0065	0.116	0.1346
Onchocerca volvulus		0.0014	0.0097	0.0098
Brugia malayi	Bromodomain containing protein	0.0079	0.1449	0.1449
Echinococcus granulosus	mitogen activated protein kinase 3	0.0052	0.09	0.1044
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0186	0.0186
Echinococcus granulosus	contactin	0.0017	0.016	0.0186
Onchocerca volvulus		0.0014	0.0097	0.0098
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0023	0.0275	0.2211
Echinococcus granulosus	solute carrier family 22	0.0014	0.0097	0.0113
Plasmodium falciparum	hexose transporter	0.0102	0.1944	0.2092
Loa Loa (eye worm)	hypothetical protein	0.0031	0.044	0.044
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0019	0.0203	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0516	0.0516
Brugia malayi	excitatory GABA receptor EXP-1A	0.0019	0.0186	0.0186
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0547	0.5597
Plasmodium falciparum	protein kinase 6	0.0434	0.8924	1
Brugia malayi	nuclear receptor NHR-88	0.0065	0.116	0.116
Trypanosoma brucei	glucose transporter 1E	0.0032	0.0462	0.4537
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0017	0.016	0.016
Schistosoma mansoni	titin	0.0017	0.016	0.0186
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0031	0.0439	0.0439
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0097	0.0097
Echinococcus granulosus	roundabout 2	0.0047	0.0788	0.0914
Echinococcus multilocularis	roundabout 2	0.0017	0.016	0.0186
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0034	0.0516	0.0516
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0065	0.116	0.116
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0186	0.0186
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0019	0.0186	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0439	0.0439
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0031	0.0439	0.0509
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0019	0.0186	0.0215
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0065	0.116	0.1346
Echinococcus multilocularis	twitchin	0.001	0.0006	0.0007
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0014	0.0097	0.0097
Echinococcus multilocularis	zinc finger protein	0.0022	0.0253	0.0294
Echinococcus granulosus	roundabout 2	0.0017	0.016	0.0186
Echinococcus granulosus	lysyl tRNA synthetase	0.0023	0.0275	0.0319
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.001	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0516	0.0516
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0065	0.116	0.116
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0019	0.0186	0.0215
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0032	0.0463	0.0414
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0017	0.0163	0.0189
Brugia malayi	Immunoglobulin I-set domain containing protein	0.001	0.0013	0.0013
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0031	0.0439	0.0509
Echinococcus multilocularis	nuclear receptor nhr 48	0.0031	0.0439	0.0509
Echinococcus granulosus	glycine receptor subunit beta	0.0019	0.0186	0.0215
Schistosoma mansoni	cpg binding protein	0.0033	0.0492	0.057
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.001	0.0013	0.0015
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0017	0.016	0.016
Echinococcus granulosus	tyrosine protein kinase otk	0.0017	0.016	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0439	0.0439
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0065	0.116	0.116
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0201	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0462	0.4537
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0065	0.116	0.1346
Brugia malayi	Nuclear hormone receptor-like 1	0.0034	0.0516	0.0516
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0415	0.0415
Brugia malayi	hypothetical protein	0.0034	0.0516	0.0516
Echinococcus granulosus	nuclear receptor nhr 48	0.0031	0.0439	0.0509
Schistosoma mansoni	hypothetical protein	0.0021	0.0241	0.0279
Loa Loa (eye worm)	hypothetical protein	0.001	0.0006	0.0006
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0102	0.1944	0.2254
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0065	0.116	0.116
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0065	0.116	0.116
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0462	0.1973
Loa Loa (eye worm)	hypothetical protein	0.003	0.0423	0.0423
Brugia malayi	Nuclear hormone receptor E75	0.0031	0.0439	0.0439
Leishmania major	protein kinase, putative	0.0032	0.0463	0.4552
Trichomonas vaginalis	CMGC family protein kinase	0.0052	0.09	0.4348
Schistosoma mansoni	coup transcription factor	0.0065	0.116	0.1346
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0052	0.09	0.1044
Schistosoma mansoni	cell adhesion molecule	0.0017	0.016	0.0186
Brugia malayi	Nuclear hormone receptor E75	0.0031	0.0439	0.0439
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0019	0.0186	0.0215
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0052	0.09	1
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0415	0.0415
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0102	0.1944	0.2254
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0097	0.0097
Brugia malayi	Fibronectin type III domain containing protein	0.003	0.0423	0.0423
Schistosoma mansoni	nephrin	0.0037	0.0584	0.0677
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0439	0.0439
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0065	0.116	0.1346
Brugia malayi	nuclear receptor RXR	0.0034	0.0516	0.0516
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0031	0.0439	0.0509
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0462	0.4537
Brugia malayi	hypothetical protein	0.0014	0.0097	0.0097
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0017	0.016	0.016
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0462	0.4537
Loa Loa (eye worm)	hypothetical protein	0.0017	0.016	0.016
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0031	0.0439	0.0509
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0065	0.116	0.1346
Echinococcus multilocularis	neurotracting:lsamp:neurotrimin:obcam	0.0017	0.016	0.0186
Toxoplasma gondii	exonuclease III APE	0.0019	0.0201	0.018
Trypanosoma brucei	glucose transporter 2A	0.0032	0.0462	0.4537
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0201	0.0118
Echinococcus granulosus	FTZ F1 alpha	0.0065	0.116	0.1346
Brugia malayi	hypothetical protein	0.0155	0.3057	0.3057
Onchocerca volvulus		0.0014	0.0097	0.0098
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0034	0.0516	0.0599
Loa Loa (eye worm)	nuclear hormone receptor	0.0031	0.0439	0.0439
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0019	0.0186	0.0186
Schistosoma mansoni	serine/threonine protein kinase	0.001	0.0006	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0186	0.0186
Echinococcus multilocularis	neuroglian	0.0017	0.016	0.0186
Echinococcus multilocularis	cpg binding protein	0.0033	0.0492	0.057
Schistosoma mansoni	neuroglian	0.0017	0.016	0.0186
Brugia malayi	nuclear receptor NHR-88	0.0031	0.0439	0.0439
Schistosoma mansoni	nAChR subunit	0.0019	0.0186	0.0215
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0065	0.116	0.1239
Schistosoma mansoni	neurotransmitter gated ion channel	0.001	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0186	0.0186
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0014	0.0097	0.0113
Schistosoma mansoni	cell adhesion molecule	0.0017	0.016	0.0186
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.044	0.051
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0186	0.0186
Echinococcus granulosus	synaptic vesicle 2 protein	0.0014	0.0097	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0097	0.0097
Echinococcus granulosus	defective proboscis extension response	0.003	0.0423	0.0491
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0462	0.4537
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0439	0.0439
Brugia malayi	Nuclear hormone receptor-like 1	0.0065	0.116	0.116
Schistosoma mansoni	zinc finger protein	0.0016	0.0125	0.0145
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0019	0.0186	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0186	0.0186
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0032	0.0463	0.0633
Echinococcus granulosus	lachesin	0.0017	0.016	0.0186
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0065	0.116	0.116
Echinococcus multilocularis	lachesin	0.0017	0.016	0.0186
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0547	0.5597
Brugia malayi	Cam kinase protein 1	0.0032	0.0463	0.0463
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.0201	0.1293
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0017	0.016	0.0186
Schistosoma mansoni	ap endonuclease	0.0019	0.0201	0.0233
Echinococcus multilocularis	hemicentin 1	0.0017	0.016	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0177	0.0177
Trypanosoma brucei	protein kinase, putative	0.0052	0.09	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0065	0.116	0.1346
Trichomonas vaginalis	CAMK family protein kinase	0.0032	0.0463	0.1979
Leishmania major	glucose transporter, lmgt3	0.0032	0.0462	0.4537
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0019	0.0186	0.0215
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.0547	0.5597
Loa Loa (eye worm)	hypothetical protein	0.001	0.0006	0.0006
Brugia malayi	hypothetical protein	0.0014	0.0097	0.0097
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0065	0.116	0.1346
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0019	0.0186	0.0215
Schistosoma mansoni	retinoic acid receptor RXR	0.0065	0.116	0.1346
Loa Loa (eye worm)	hypothetical protein	0.003	0.0423	0.0423
Echinococcus granulosus	histone lysine methyltransferase setb	0.0018	0.0177	0.0205
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0163	0.0189
Loa Loa (eye worm)	hypothetical protein	0.001	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0788	0.0788
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0031	0.0439	0.0509
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0275	0.0319
Echinococcus granulosus	thyroid hormone receptor alpha	0.0031	0.0439	0.0509
Echinococcus granulosus	General substrate transporter	0.0088	0.1642	0.1904
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0462	0.1973
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0032	0.0463	0.0414
Echinococcus granulosus	calcium dependent protein kinase	0.0029	0.0412	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0065	0.116	0.116
Brugia malayi	photoreceptor-specific nuclear receptor	0.0065	0.116	0.116
Schistosoma mansoni	nAChR subunit	0.0019	0.0186	0.0215
Onchocerca volvulus		0.0442	0.911	0.9767
Plasmodium falciparum	protein kinase 7	0.0289	0.5875	0.6546
Loa Loa (eye worm)	hypothetical protein	0.0065	0.116	0.116
Onchocerca volvulus		0.0019	0.0186	0.0193
Echinococcus multilocularis	ecdysone induced protein 78C	0.0065	0.116	0.1346
Loa Loa (eye worm)	hypothetical protein	0.001	0.0006	0.0006
Onchocerca volvulus	Protein ultraspiracle homolog	0.0065	0.116	0.1239
Onchocerca volvulus		0.0014	0.0097	0.0098
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.001	0.0006	0.0006
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0065	0.116	0.1346
Schistosoma mansoni	glucose transport protein	0.0102	0.1944	0.2254
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0019	0.0186	0.0215
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0052	0.09	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0097	0.0097
Brugia malayi	Cation transporter family protein	0.0019	0.0186	0.0186
Loa Loa (eye worm)	hypothetical protein	0.003	0.0423	0.0423
Schistosoma mansoni	glucose transport protein	0.0102	0.1944	0.2254
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0032	0.0462	0.4537
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0019	0.0186	0.0186
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0023	0.0275	0.3046
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.004	0.0628	0.0728
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0065	0.116	0.1346
Loa Loa (eye worm)	hypothetical protein	0.003	0.0423	0.0423
Brugia malayi	Sugar transporter family protein	0.0102	0.1944	0.1944
Brugia malayi	lysyl-tRNA synthetase	0.0023	0.0275	0.0275
Onchocerca volvulus		0.0014	0.0097	0.0098
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0065	0.116	0.1346
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0031	0.044	0.1855
Schistosoma mansoni	sugar transporter	0.0014	0.0097	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0097	0.0097
Schistosoma mansoni	nuclear receptor nhr-48	0.0031	0.0439	0.0509
Loa Loa (eye worm)	hypothetical protein	0.003	0.0423	0.0423
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0547	0.5597
Loa Loa (eye worm)	hypothetical protein	0.0065	0.116	0.116
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0052	0.09	1
Schistosoma mansoni	vesicular amine transporter	0.003	0.0423	0.0491
Echinococcus multilocularis	glycine receptor subunit beta	0.0019	0.0186	0.0215
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0032	0.0463	0.0414
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0031	0.044	0.044
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0462	0.4537
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0031	0.0439	0.0509
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0014	0.0097	0.2954
Loa Loa (eye worm)	CAMK protein kinase	0.001	0.0006	0.0006
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0275	0.0319
Schistosoma mansoni	septate junction protein	0.0017	0.016	0.0186
Echinococcus multilocularis	lysyl tRNA synthetase	0.0023	0.0275	0.0319
Onchocerca volvulus		0.001	0.0006	0.0001
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.001	0.0013	0.0015
Echinococcus multilocularis	dnaJ subfamily B	0.0419	0.8623	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0065	0.116	0.116
Trypanosoma cruzi	hexose transporter, putative	0.0017	0.0159	0.0774
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0017	0.016	0.016
Echinococcus granulosus	dnaJ subfamily B	0.0419	0.8623	1
Schistosoma mansoni	serine/threonine protein kinase	0.0032	0.0463	0.0537
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0019	0.0186	0.0215
Echinococcus granulosus	zinc finger protein	0.0022	0.0253	0.0294
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0462	0.4537
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0097	0.0097
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0036	0.0547	0.0778
Schistosoma mansoni	zinc finger protein	0.0022	0.0253	0.0294
Echinococcus granulosus	fetal alzheimer antigen falz	0.0025	0.0317	0.0368
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0019	0.0186	0.0186
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0017	0.016	0.016
Brugia malayi	Immunoglobulin I-set domain containing protein	0.003	0.0423	0.0423
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0201	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0439	0.0439
Loa Loa (eye worm)	ACC-1 protein	0.0019	0.0186	0.0186
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0065	0.116	0.116
Onchocerca volvulus		0.0014	0.0097	0.0098
Echinococcus multilocularis	FTZ F1 alpha	0.0065	0.116	0.1346
Brugia malayi	Steroid receptor seven-up type 2	0.0065	0.116	0.116
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0097	0.0097
Schistosoma mansoni	zinc finger protein	0.0031	0.0439	0.0509
Brugia malayi	conserved hypotetical protein	0.0031	0.0439	0.0439
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0516	0.0516
Onchocerca volvulus		0.0019	0.0186	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0065	0.116	0.116
Schistosoma mansoni	nAChR subunit	0.0019	0.0186	0.0215
Brugia malayi	protein unc-22	0.001	0.0006	0.0006
Schistosoma mansoni	hypothetical protein	0.0102	0.1944	0.2254
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0463	0.0537
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0462	0.4537
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0032	0.0463	0.0414
Echinococcus granulosus	titin	0.001	0.0006	0.0007
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0018	0.0177	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0017	0.016	0.016
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0065	0.116	0.116
Loa Loa (eye worm)	ACC-1 protein	0.0019	0.0186	0.0186
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0019	0.0186	0.0186
Echinococcus granulosus	titin	0.001	0.0006	0.0007
Schistosoma mansoni	ap endonuclease	0.0019	0.0201	0.0233
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0014	0.0097	0.0113
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0031	0.0439	0.0509
Entamoeba histolytica	protein kinase, putative	0.0032	0.0463	1
Brugia malayi	follicle stimulating hormone receptor	0.023	0.4631	0.4631
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0019	0.0186	0.0186
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0019	0.0186	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0186	0.0186
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0023	0.0275	0.2211
Brugia malayi	F/Y-rich N-terminus family protein	0.0011	0.0026	0.0026
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0462	0.4537
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0058	0.1021	0.1598
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0023	0.0275	0.0961
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.001	0.0006	0.0006
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0031	0.0439	0.0509
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0017	0.016	0.016
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0065	0.116	0.116
Brugia malayi	nuclear hormone receptor	0.0065	0.116	0.116
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.001	0.0006	0.0006
Onchocerca volvulus		0.0031	0.0439	0.0465
Echinococcus granulosus	peroxidasin	0.0017	0.016	0.0186
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0032	0.0463	0.0537
Brugia malayi	Cation transporter family protein	0.0019	0.0186	0.0186
Echinococcus multilocularis	tyrosine protein kinase otk	0.0017	0.016	0.0186
Echinococcus granulosus	mitogen activated protein kinase	0.0052	0.09	0.1044
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0019	0.0186	0.0215
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0019	0.0186	0.0215
Brugia malayi	ecdysteroid receptor	0.0065	0.116	0.116
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0063	0.1119	0.1298
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0439	0.0439
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0186	0.0186
Loa Loa (eye worm)	hypothetical protein	0.001	0.0006	0.0006
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0019	0.0201	0.7075
Onchocerca volvulus	Putative transporter	0.0014	0.0097	0.0098
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0065	0.116	0.1346
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0065	0.116	0.116
Echinococcus granulosus	solute carrier family 22	0.0014	0.0097	0.0113
Mycobacterium ulcerans	sugar transporter	0.0014	0.0097	0.2954
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0017	0.016	0.0186
Loa Loa (eye worm)	TK protein kinase	0.001	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0788	0.0788
Schistosoma mansoni	glucose transport protein	0.0102	0.1944	0.2254
Loa Loa (eye worm)	hypothetical protein	0.0065	0.116	0.116
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0032	0.0463	0.0463
Plasmodium vivax	hexose transporter	0.0102	0.1944	0.2092
Onchocerca volvulus		0.0014	0.0097	0.0098
Schistosoma mansoni	nuclear receptor	0.0031	0.0439	0.0509
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0031	0.0439	0.0439
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0065	0.116	0.1346
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0019	0.0186	0.0215
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0434	0.8924	1
Echinococcus granulosus	nAChR subunit	0.0019	0.0186	0.0215
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0017	0.016	0.016
Leishmania major	hypothetical protein, conserved	0.0016	0.0125	0.035
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1322	0.1322
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0462	0.1973
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0019	0.0186	0.0186
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0031	0.044	1
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0034	0.0516	0.0599
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0031	0.044	0.051
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0018	0.0177	0.0205
Loa Loa (eye worm)	hypothetical protein	0.001	0.0006	0.0006
Brugia malayi	Prion-like-	0.0017	0.016	0.016
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0097	0.0113
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0017	0.016	0.0186
Mycobacterium ulcerans	integral membrane transport protein	0.0014	0.0097	0.2954
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.001	0.0006	0.0006
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0017	0.016	0.016
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.003	0.0423	0.0491
Toxoplasma gondii	lysine-tRNA ligase	0.0023	0.0275	0.0307
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0102	0.1944	0.2254
Schistosoma mansoni	cell adhesion molecule	0.004	0.0628	0.0728
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0032	0.0463	0.0414
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0019	0.0203	1
Schistosoma mansoni	titin	0.001	0.0006	0.0007
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.0547	0.5597
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0019	0.0186	0.0186
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0052	0.09	0.1389
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0201	0.9868
Echinococcus granulosus	solute carrier family 22	0.0014	0.0097	0.0113
Onchocerca volvulus		0.0014	0.0097	0.0098
Schistosoma mansoni	sugar transporter	0.0014	0.0097	0.0113
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0102	0.1944	0.2254
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.003	0.0423	0.0491
Plasmodium falciparum	proline--tRNA ligase	0.0036	0.0547	0.0509
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0017	0.016	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0017	0.016	0.016
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0032	0.0463	0.0463
Echinococcus multilocularis	titin	0.001	0.0006	0.0007
Loa Loa (eye worm)	sugar transporter	0.0102	0.1944	0.1944
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0065	0.116	0.1346
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0031	0.044	0.9498
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0019	0.0186	0.0186
Echinococcus multilocularis	General substrate transporter	0.0088	0.1642	0.1904
Giardia lamblia	Kinase, CMGC MAPK	0.0052	0.09	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0017	0.016	0.0186
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.044	0.051
Echinococcus multilocularis	mitogen activated protein kinase	0.0052	0.09	0.1044
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.002	0.0216	0.0641
Schistosoma mansoni	cpg binding protein	0.0029	0.0415	0.0481
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0097	0.0097
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0019	0.0186	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0065	0.116	0.116
Brugia malayi	ecdysone receptor	0.0031	0.0439	0.0439
Loa Loa (eye worm)	hypothetical protein	0.0017	0.016	0.016
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0463	0.0537
Schistosoma mansoni	septate junction protein	0.0017	0.016	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0319	0.0319
Schistosoma mansoni	bromodomain containing protein	0.0067	0.1196	0.1387
Loa Loa (eye worm)	hypothetical protein	0.0065	0.116	0.116
Onchocerca volvulus		0.0014	0.0097	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0097	0.0097
Brugia malayi	PHD-finger family protein	0.0027	0.0368	0.0368
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0013	0.006	0.006
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0019	0.0186	0.0186
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0019	0.0186	0.0215
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0097	0.0113
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0462	0.4537
Brugia malayi	Major Facilitator Superfamily protein	0.0014	0.0097	0.0097
Onchocerca volvulus		0.0031	0.0439	0.0465
Toxoplasma gondii	facilitative glucose transporter GT1	0.0102	0.1944	0.3196
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0037	0.0571	0.0662

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	= 49.99 %	Inhibition of alpha-1G calcium channel in human HEK293 cells at 10 uM by whole-cell patch-clamp method	ChEMBL.	23395659

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2334623

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1729579