Detailed information for compound 1730662

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 359.847 | Formula: C20H22ClNO3
  • H donors: 2 H acceptors: 2 LogP: 3.23 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc2CCN3[C@@H](c2cc1O)C[C@](CC3)(O)c1ccc(cc1)Cl
  • InChi: 1S/C20H22ClNO3/c1-25-19-10-13-6-8-22-9-7-20(24,14-2-4-15(21)5-3-14)12-17(22)16(13)11-18(19)23/h2-5,10-11,17,23-24H,6-9,12H2,1H3/t17-,20+/m1/s1
  • InChiKey: RHYAPXDEVZEEMS-XLIONFOSSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens dopamine receptor D1 Starlite/ChEMBL References
Homo sapiens dopamine receptor D2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum 5-hydroxytryptamine receptor, putative Get druggable targets OG5_132667 All targets in OG5_132667
Schistosoma japonicum 5-hydroxytryptamine receptor 1, putative Get druggable targets OG5_132667 All targets in OG5_132667
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0032 0.0349 0.0349
Schistosoma mansoni signal transduction protein lnk-related 0.0034 0.0436 0.0436
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0044 0.0754 0.0754
Echinococcus multilocularis SH2 domain containing protein 7 0.0034 0.0436 0.0436
Echinococcus multilocularis SHC transforming protein 3 0.0034 0.0436 0.0436
Schistosoma mansoni hypothetical protein 0.0034 0.0408 0.0408
Schistosoma mansoni hypothetical protein 0.0307 0.9387 0.9387
Echinococcus granulosus SH2 motif 0.0034 0.0436 0.0436
Trichomonas vaginalis 60S ribosomal protein L19, putative 0.0026 0.0163 0.0249
Trichomonas vaginalis 60S ribosomal protein L19, putative 0.0026 0.0163 0.0249
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0207 0.6098 0.6098
Echinococcus granulosus epidermal growth factor receptor kinase 0.0034 0.0408 0.0408
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0084 0.2063 0.2063
Loa Loa (eye worm) hypothetical protein 0.0034 0.0436 0.0436
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0025 0.0128 0.0196
Trypanosoma cruzi 60S ribosomal protein L19, putative 0.0026 0.0163 0.0249
Brugia malayi Guanylate kinase family protein 0.0034 0.0408 0.0408
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0249 0.7145
Echinococcus granulosus tyrosine protein kinase Src42A 0.0282 0.8579 0.8579
Loa Loa (eye worm) TK/FER protein kinase 0.0044 0.0754 0.0754
Schistosoma mansoni tyrosine kinase 0.0044 0.0754 0.0754
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0128 0.0196
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0071 0.0108
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0035 0.0452 0.0452
Echinococcus multilocularis survival motor neuron protein 1 0.0236 0.705 0.705
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0076 0.1801 0.2757
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0128 0.0196
Brugia malayi Protein kinase domain containing protein 0.0044 0.0754 0.0754
Loa Loa (eye worm) hypothetical protein 0.0034 0.0436 0.0436
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.01 0.2576 0.3317
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0034 0.0436 0.0436
Brugia malayi SH2 domain containing protein 0.0044 0.0754 0.0754
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0034 0.0436 0.0436
Leishmania major hypothetical protein, conserved 0.0104 0.2707 1
Schistosoma mansoni lamin 0.0027 0.0188 0.0188
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0034 0.0436 0.3563
Echinococcus granulosus NCK adaptor protein 0.0068 0.154 0.154
Loa Loa (eye worm) TK protein kinase 0.0258 0.7765 0.7765
Onchocerca volvulus 0.0034 0.0436 0.3563
Brugia malayi Variant SH3 domain containing protein 0.0068 0.154 0.154
Entamoeba histolytica hypothetical protein 0.0034 0.0408 0.0526
Echinococcus granulosus breast cancer anti estrogen resistance protein 0.0034 0.0408 0.0408
Loa Loa (eye worm) SH2 domain-containing protein 0.0034 0.0436 0.0436
Onchocerca volvulus 0.0044 0.0754 0.8124
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0044 0.0754 0.0754
Echinococcus multilocularis fch and double sh3 domains protein 2 0.0034 0.0408 0.0408
Trichomonas vaginalis neutrophil cytosolic factor 2, neutrophil NADPH oxidase factor, putative 0.0034 0.0408 0.0625
Brugia malayi SH2 domain containing protein 0.0034 0.0436 0.0436
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0034 0.0436 0.0436
Plasmodium vivax 60S ribosomal protein L19, putative 0.0026 0.0163 0.4663
Schistosoma mansoni hypothetical protein 0.0034 0.0408 0.0408
Onchocerca volvulus 0.0044 0.0754 0.8124
Loa Loa (eye worm) phosphatidylinositol 3 0.026 0.7839 0.7839
Entamoeba histolytica BAR/SH3 domain containing protein 0.0034 0.0408 0.0526
Echinococcus granulosus hypothetical protein 0.0034 0.0436 0.0436
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0025 0.0128 0.0128
Brugia malayi SH3 domain containing protein 0.0034 0.0408 0.0408
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0128 0.0196
Brugia malayi hypothetical protein 0.0034 0.0436 0.0436
Brugia malayi 60S ribosomal protein L19 0.0026 0.0163 0.0163
Entamoeba histolytica protein kinase, putative 0.0258 0.7765 1
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0188 0.0188
Brugia malayi MH2 domain containing protein 0.0119 0.3215 0.3215
Echinococcus multilocularis tyrosine kinase 0.0044 0.0754 0.0754
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0034 0.0436 0.0436
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0044 0.0754 0.0754
Echinococcus multilocularis hematopoietic lineage cell specific protein 0.0034 0.0408 0.0408
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0034 0.0436 0.0562
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0068 0.154 0.154
Entamoeba histolytica hypothetical protein 0.0034 0.0408 0.0526
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0044 0.0754 0.0971
Loa Loa (eye worm) TK/FER protein kinase 0.0044 0.0754 0.0754
Entamoeba histolytica hypothetical protein 0.0034 0.0408 0.0526
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0304 0.9291 0.9291
Plasmodium falciparum 60S ribosomal protein L19 0.0026 0.0163 0.4663
Brugia malayi Variant SH3 domain containing protein 0.0034 0.0408 0.0408
Schistosoma mansoni adapter molecule crk 0.0068 0.154 0.154
Echinococcus granulosus hematopoietic lineage cell specific protein 0.0034 0.0408 0.0408
Onchocerca volvulus 0.0034 0.0408 0.316
Echinococcus granulosus SH2 domain containing protein 7 0.0034 0.0436 0.0436
Echinococcus multilocularis c src tyrosine kinase 0.0078 0.1857 0.1857
Loa Loa (eye worm) TK/FER protein kinase 0.0044 0.0754 0.0754
Loa Loa (eye worm) hypothetical protein 0.0144 0.4028 0.4028
Entamoeba histolytica hypothetical protein, conserved 0.0034 0.0408 0.0526
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0128 0.0196
Plasmodium vivax importin-beta 2, putative 0.0029 0.0249 0.7145
Brugia malayi Protein kinase domain containing protein 0.0044 0.0754 0.0754
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0128 0.0196
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0034 0.0436 0.0436
Onchocerca volvulus 0.0034 0.0408 0.316
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0036 0.048 0.048
Echinococcus multilocularis tensin 0.0034 0.0436 0.0436
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.022 0.6533 1
Schistosoma mansoni signal transducing adapter molecule (stam) 0.0034 0.0408 0.0408
Schistosoma mansoni dynamin-associated protein 0.0034 0.0408 0.0408
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0408 0.0625
Schistosoma mansoni tyrosine kinase 0.0078 0.1857 0.1857
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0128 0.0128
Echinococcus multilocularis expressed protein 0.0034 0.0408 0.0408
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0128 0.0196
Loa Loa (eye worm) TK/FER protein kinase 0.0044 0.0754 0.0754
Brugia malayi RNA, U transporter 1 0.0082 0.1991 0.1991
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0025 0.0128 0.0128
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0304 0.9291 0.9291
Schistosoma mansoni SH2A 0.0034 0.0436 0.0436
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0034 0.0436 0.0436
Leishmania major 60S ribosomal protein L19, putative 0.0026 0.0163 0.0601
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0307 0.9387 0.9387
Echinococcus multilocularis lamin dm0 0.0027 0.0188 0.0188
Brugia malayi Variant SH3 domain containing protein 0.0034 0.0408 0.0408
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0032 0.0349 1
Echinococcus granulosus ribosomal protein L19 0.0026 0.0163 0.0163
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0128 0.0196
Loa Loa (eye worm) TK/FER protein kinase 0.0044 0.0754 0.0754
Loa Loa (eye worm) phosphatidylinositol 3 0.0025 0.0128 0.0128
Plasmodium falciparum importin beta, putative 0.0029 0.0249 0.7145
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0032 0.0349 1
Loa Loa (eye worm) protein kinase C and casein kinase substrate in neurons protein 2 0.0034 0.0408 0.0408
Entamoeba histolytica hypothetical protein 0.0034 0.0408 0.0526
Brugia malayi intermediate filament protein 0.0027 0.0188 0.0188
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0076 0.1801 0.2319
Entamoeba histolytica 60S ribosomal protein L19, putative 0.0026 0.0163 0.021
Schistosoma mansoni tar DNA-binding protein 0.0063 0.138 0.138
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0032 0.0349 0.1937
Echinococcus granulosus SHC transforming protein 3 0.0034 0.0436 0.0436
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0025 0.0128 0.0128
Onchocerca volvulus 0.0034 0.0436 0.3563
Loa Loa (eye worm) hypothetical protein 0.0034 0.0436 0.0436
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0408 0.0625
Loa Loa (eye worm) p53BP2 0.0034 0.0408 0.0408
Loa Loa (eye worm) hypothetical protein 0.0034 0.0408 0.0408
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0034 0.0436 0.0436
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0128 0.0196
Brugia malayi Myosin tail family protein 0.0034 0.0408 0.0408
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0025 0.0128 0.0709
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0128 0.0196
Leishmania major hypothetical protein, conserved 0.0034 0.0408 0.1508
Schistosoma mansoni 60S ribosomal protein L19 0.0026 0.0163 0.0163
Echinococcus granulosus growth factor receptor bound protein 2 0.0068 0.154 0.154
Trypanosoma cruzi 60S ribosomal protein L19, putative 0.0026 0.0163 0.0249
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0025 0.0128 0.0196
Loa Loa (eye worm) hypothetical protein 0.0044 0.0754 0.0754
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0032 0.0349 0.0349
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0034 0.0436 0.0436
Echinococcus granulosus tyrosine kinase 0.0044 0.0754 0.0754
Loa Loa (eye worm) thyroid receptor interactor 0.0034 0.0408 0.0408
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.022 0.6533 1
Brugia malayi Variant SH3 domain containing protein 0.0068 0.154 0.154
Echinococcus granulosus tyrosine protein kinase shark 0.0044 0.0754 0.0754
Echinococcus granulosus suppressor of cytokine signaling 6 0.0034 0.0436 0.0436
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0054 0.1085 0.3803
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0421 0.0421
Echinococcus granulosus slit robo rho gtpase activating protein 1 0.0034 0.0408 0.0408
Loa Loa (eye worm) hypothetical protein 0.0068 0.154 0.154
Schistosoma mansoni C-fyn 0.0034 0.0408 0.0408
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0078 0.1857 0.1857
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0128 0.0196
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0034 0.0436 0.3563
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0144 0.4028 0.4028
Trichomonas vaginalis 60S ribosomal protein L19, putative 0.0026 0.0163 0.0249
Schistosoma mansoni formin binding protein and related proteins 0.0034 0.0408 0.0408
Loa Loa (eye worm) hypothetical protein 0.0034 0.0408 0.0408
Schistosoma mansoni tensin 0.0034 0.0436 0.0436
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0152 0.4306 0.6592
Onchocerca volvulus 0.0034 0.0436 0.3563
Echinococcus granulosus tyrosine protein kinase HCK 0.0258 0.7765 0.7765
Entamoeba histolytica hypothetical protein 0.0034 0.0408 0.0526
Loa Loa (eye worm) hypothetical protein 0.0034 0.0408 0.0408
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0025 0.0128 0.0709
Brugia malayi TAR-binding protein 0.0063 0.138 0.138
Brugia malayi Peripheral plasma membrane protein CASK 0.0034 0.0408 0.0408
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0076 0.1801 0.2757
Schistosoma mansoni sorting nexin 0.0034 0.0408 0.0408
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0076 0.1801 0.2319
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0408 0.0625
Schistosoma mansoni survival motor neuron protein 0.0048 0.0885 0.0885
Onchocerca volvulus 0.0034 0.0436 0.3563
Brugia malayi Fes/CIP4 homology domain containing protein 0.0034 0.0408 0.0408
Loa Loa (eye worm) hypothetical protein 0.0034 0.0436 0.0436
Echinococcus granulosus intersectin 2 0.0034 0.0408 0.0408
Toxoplasma gondii target of rapamycin (TOR), putative 0.0025 0.0128 0.3661
Brugia malayi SH2 domain containing protein 0.0034 0.0436 0.0436
Echinococcus granulosus tyrosine kinase 0.0292 0.8897 0.8897
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0025 0.0128 0.0472
Echinococcus multilocularis Zinc finger, PHD finger 0.0032 0.0349 0.0349
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0128 0.0196
Onchocerca volvulus 0.0034 0.0436 0.3563
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0025 0.0128 0.0709
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0032 0.0349 0.0449
Schistosoma mansoni tar DNA-binding protein 0.0063 0.138 0.138
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0034 0.0436 0.0436
Trypanosoma cruzi paraflagellar rod protein 5, putative 0.0034 0.0408 0.0625
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.022 0.6533 1
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0034 0.0436 0.0436
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.022 0.6533 0.8413
Loa Loa (eye worm) guanylate kinase 0.0034 0.0408 0.0408
Schistosoma mansoni sorbin 0.0034 0.0408 0.0408
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.022 0.6533 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.022 0.6533 1
Onchocerca volvulus 0.0034 0.0408 0.316
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0128 0.0196
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0032 0.0349 0.0534
Echinococcus granulosus rho guanine nucleotide exchange factor 7 0.0034 0.0408 0.0408
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0128 0.0196
Loa Loa (eye worm) hypothetical protein 0.0036 0.048 0.048
Brugia malayi hypothetical protein 0.0044 0.0754 0.0754
Schistosoma mansoni hypothetical protein 0.0034 0.0436 0.0436
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0408 0.0625
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0128 0.0196
Brugia malayi hypothetical protein 0.0236 0.705 0.705
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0408 0.0625
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0025 0.0128 0.0472
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0025 0.0128 0.0196
Echinococcus multilocularis slit robo rho gtpase activating protein 1 0.0034 0.0408 0.0408
Echinococcus granulosus SH2 domain containing adapter protein F 0.0034 0.0436 0.0436
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0408 0.0625
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0128 0.0196
Schistosoma mansoni suppressor of cytokine signaling 0.0034 0.0436 0.0436
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0938 0.0938
Loa Loa (eye worm) hypothetical protein 0.0034 0.0436 0.0436
Loa Loa (eye worm) hypothetical protein 0.0034 0.0436 0.0436
Schistosoma mansoni hypothetical protein 0.0048 0.0885 0.0885
Echinococcus granulosus lamin dm0 0.0027 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0034 0.0421 0.0421
Loa Loa (eye worm) hypothetical protein 0.0029 0.0249 0.0249
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0076 0.1801 1
Echinococcus multilocularis tyrosine protein kinase Blk 0.0292 0.8897 0.8897
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0032 0.0349 0.0349
Echinococcus granulosus tyrosine protein kinase ABL1 0.0044 0.0754 0.0754
Echinococcus multilocularis transfer RNA-Ala 0.0034 0.0408 0.0408
Echinococcus multilocularis nostrin 0.0034 0.0408 0.0408
Echinococcus multilocularis signal transduction protein lnk realted 0.0034 0.0436 0.0436
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0025 0.0128 0.0128
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0034 0.0436 0.0436
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0034 0.0436 0.0436
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0076 0.1801 0.1801
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0128 0.0196
Schistosoma mansoni run and tbc1 domain containing 0.0034 0.0408 0.0408
Echinococcus granulosus Spectrin alpha actinin 0.0034 0.0408 0.0408
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0408 0.0625
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0032 0.0349 0.0534
Brugia malayi Tyrosine-protein kinase abl-1 0.0078 0.1857 0.1857
Loa Loa (eye worm) hypothetical protein 0.0034 0.0408 0.0408
Schistosoma mansoni lamin 0.0027 0.0188 0.0188
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0108 0.2854 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0034 0.0408 0.0408
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0068 0.154 0.154
Loa Loa (eye worm) STAT protein 0.0034 0.0436 0.0436
Schistosoma mansoni growth factor receptor-bound protein 0.0068 0.154 0.154
Leishmania major phosphatidylinositol 3-kinase, putative 0.0032 0.0349 0.1289
Echinococcus granulosus snurportin 1 0.0307 0.9387 0.9387
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0128 0.0196
Echinococcus granulosus endophilin A3 0.0034 0.0408 0.0408
Schistosoma mansoni nck2/grb4 0.0068 0.154 0.154
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0128 0.0196
Trypanosoma cruzi hypothetical protein, conserved 0.0094 0.2379 0.3641
Entamoeba histolytica protein kinase, putative 0.0034 0.0408 0.0526
Echinococcus granulosus expressed conserved protein 0.0034 0.0436 0.0436
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0408 0.0625
Schistosoma mansoni eps8-related protein 0.0034 0.0408 0.0408
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0249 0.0249
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0032 0.0349 0.0349
Loa Loa (eye worm) TAR-binding protein 0.0063 0.138 0.138
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0128 0.0196
Loa Loa (eye worm) phosphatidylinositol 3 0.0025 0.0128 0.0128
Onchocerca volvulus Putative cortactin 0.0034 0.0408 0.316
Loa Loa (eye worm) hypothetical protein 0.0026 0.0163 0.0163
Schistosoma mansoni tensin 0.0034 0.0436 0.0436
Onchocerca volvulus 0.0034 0.0408 0.316
Loa Loa (eye worm) hypothetical protein 0.0034 0.0436 0.0436
Leishmania major 60S ribosomal protein L19, putative 0.0026 0.0163 0.0601
Onchocerca volvulus 0.0044 0.0754 0.8124
Loa Loa (eye worm) hypothetical protein 0.0034 0.0408 0.0408
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0938 0.0938
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0152 0.4306 0.6592
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0938 0.0938
Brugia malayi Sex muscle abnormal protein 5 0.0068 0.154 0.154
Echinococcus multilocularis N chimaerin 0.0034 0.0436 0.0436
Schistosoma mansoni shc transforming protein 0.0034 0.0436 0.0436
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.022 0.6533 0.6533
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0034 0.0436 0.0436
Echinococcus granulosus tyrosine protein kinase Blk 0.0292 0.8897 0.8897
Echinococcus multilocularis SH2 motif 0.0034 0.0436 0.0436
Entamoeba histolytica hypothetical protein 0.0176 0.5081 0.6543
Loa Loa (eye worm) hypothetical protein 0.0034 0.0436 0.0436
Entamoeba histolytica BAR/SH3 domain containing protein 0.0034 0.0408 0.0526
Brugia malayi Protein kinase domain containing protein 0.0044 0.0754 0.0754
Schistosoma mansoni tar DNA-binding protein 0.0063 0.138 0.138
Onchocerca volvulus 0.0044 0.0754 0.8124
Loa Loa (eye worm) SH2 domain-containing protein 0.0034 0.0436 0.0436
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0144 0.4028 0.4028
Echinococcus multilocularis Spectrin alpha actinin 0.0034 0.0408 0.0408
Entamoeba histolytica hypothetical protein 0.0035 0.0452 0.0582
Schistosoma mansoni tar DNA-binding protein 0.0063 0.138 0.138
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0032 0.0349 0.0534
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0032 0.0349 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0207 0.6098 0.6098
Loa Loa (eye worm) RNA binding protein 0.0063 0.138 0.138
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0885 0.0885
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0032 0.0349 0.0349
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0034 0.0436 0.0436
Schistosoma mansoni dreadlocks/dock 0.0034 0.0408 0.0408
Echinococcus multilocularis tyrosine protein kinase Abl 0.0078 0.1857 0.1857
Loa Loa (eye worm) TK/FER protein kinase 0.0044 0.0754 0.0754
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0128 0.0196
Loa Loa (eye worm) hypothetical protein 0.0027 0.0188 0.0188
Loa Loa (eye worm) TK/FER protein kinase 0.0044 0.0754 0.0754
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0304 0.9291 0.9291
Brugia malayi Spectrin alpha chain 0.0034 0.0408 0.0408
Entamoeba histolytica hypothetical protein 0.0034 0.0408 0.0526
Echinococcus multilocularis SH2 motif 0.0034 0.0436 0.0436
Brugia malayi Variant SH3 domain containing protein 0.0036 0.048 0.048
Brugia malayi SH2 domain containing protein 0.0044 0.0754 0.0754
Echinococcus multilocularis musashi 0.0027 0.0188 0.0188
Entamoeba histolytica hypothetical protein 0.0023 0.0071 0.0091
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0282 0.8579 0.8579
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0035 0.0452 0.0452
Trypanosoma brucei 60S ribosomal protein L19, putative 0.0026 0.0163 0.0903
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0034 0.0436 0.0436
Echinococcus granulosus expressed protein 0.0034 0.0408 0.0408
Onchocerca volvulus 0.0048 0.0885 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.181 0.181
Schistosoma mansoni Dab2-interacting protein-like 0.0034 0.0408 0.0408
Echinococcus multilocularis lamin 0.0027 0.0188 0.0188
Echinococcus granulosus ribosomal protein L19 0.0026 0.0163 0.0163
Schistosoma mansoni tyrosine kinase 0.0173 0.4995 0.4995
Schistosoma mansoni tar DNA-binding protein 0.0063 0.138 0.138
Loa Loa (eye worm) hypothetical protein 0.0236 0.705 0.705
Echinococcus granulosus fch and double sh3 domains protein 2 0.0034 0.0408 0.0408
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0032 0.0349 0.0349
Loa Loa (eye worm) phosphatidylinositol 3 0.0066 0.1473 0.1473
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0726 0.0726
Echinococcus multilocularis tyrosine protein kinase HCK 0.0258 0.7765 0.7765
Loa Loa (eye worm) hypothetical protein 0.0034 0.0408 0.0408
Echinococcus granulosus signal transduction protein lnk realted 0.0034 0.0436 0.0436
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0176 0.5081 0.6543
Schistosoma mansoni intermediate filament proteins 0.0027 0.0188 0.0188
Schistosoma mansoni slit-robo rho gtpase activating protein 0.0034 0.0408 0.0408
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0076 0.1801 0.2757
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0032 0.0349 0.0534
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0128 0.0196
Loa Loa (eye worm) hypothetical protein 0.0034 0.0408 0.0408
Brugia malayi Variant SH3 domain containing protein 0.0034 0.0408 0.0408
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0034 0.0436 0.0436
Brugia malayi RNA binding protein 0.0063 0.138 0.138
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0071 0.0108
Echinococcus multilocularis intersectin 2 0.0034 0.0408 0.0408
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0076 0.1801 0.1801
Echinococcus multilocularis tar DNA binding protein 0.0063 0.138 0.138
Loa Loa (eye worm) TK/FER protein kinase 0.0044 0.0754 0.0754
Echinococcus multilocularis SH2 motif 0.0034 0.0436 0.0436
Schistosoma mansoni tensin 0.0034 0.0436 0.0436
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0032 0.0349 0.0449
Brugia malayi Src substrate cortactin 0.0034 0.0408 0.0408
Giardia lamblia Ribosomal protein L19 0.0026 0.0163 0.057
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0034 0.0436 0.0436
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0128 0.0196
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0025 0.0128 0.0196
Brugia malayi Variant SH3 domain containing protein 0.0034 0.0408 0.0408
Schistosoma mansoni growth factor receptor-bound protein 0.0068 0.154 0.154
Entamoeba histolytica 60S ribosomal protein L19, putative 0.0026 0.0163 0.021
Schistosoma mansoni tensin-related 0.0034 0.0436 0.0436
Onchocerca volvulus 0.0044 0.0754 0.8124
Brugia malayi Tensin 0.0034 0.0436 0.0436
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0032 0.0349 0.1289
Schistosoma mansoni importin beta-1 0.0029 0.0249 0.0249
Trichomonas vaginalis p67phox protein, putative 0.0034 0.0408 0.0625
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.3215 0.3215
Brugia malayi Variant SH3 domain containing protein 0.0034 0.0408 0.0408
Echinococcus granulosus c src tyrosine kinase 0.0078 0.1857 0.1857
Leishmania major importin beta-1 subunit, putative 0.0023 0.0071 0.0261
Brugia malayi Protein kinase domain containing protein 0.0044 0.0754 0.0754
Toxoplasma gondii ribosomal protein RPL19 0.0026 0.0163 0.4663
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0249 0.1384
Loa Loa (eye worm) TK/FER protein kinase 0.0044 0.0754 0.0754
Schistosoma mansoni vav2 0.0036 0.048 0.048
Echinococcus granulosus suppressor of cytokine signaling 7 0.0034 0.0436 0.0436
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0128 0.0196
Brugia malayi STAT protein, DNA binding domain containing protein 0.0034 0.0436 0.0436
Echinococcus multilocularis snurportin 1 0.0307 0.9387 0.9387
Trypanosoma brucei conserved protein 0.0034 0.0408 0.2267
Echinococcus granulosus intermediate filament protein 0.0027 0.0188 0.0188
Echinococcus granulosus tar DNA binding protein 0.0063 0.138 0.138
Echinococcus granulosus tyrosine protein kinase Srms 0.0044 0.0754 0.0754
Schistosoma mansoni tyrosine kinase 0.0078 0.1857 0.1857
Echinococcus multilocularis tensin 0.0034 0.0436 0.0436
Schistosoma mansoni sh3-containing grb2-like protein 1 (endophilin II) 0.0034 0.0408 0.0408
Brugia malayi protein-tyrosine kinase 0.0292 0.8897 0.8897
Schistosoma mansoni suppressor of cytokine signaling 0.0034 0.0436 0.0436
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0128 0.0196
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0034 0.0436 0.0436
Entamoeba histolytica hypothetical protein 0.0034 0.0408 0.0526
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0032 0.0349 1
Brugia malayi protein-tyrosine kinase 0.0034 0.0408 0.0408
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0128 0.0196
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0408 0.0625
Loa Loa (eye worm) hypothetical protein 0.0026 0.0172 0.0172
Trypanosoma cruzi 60S ribosomal protein L19, putative 0.0026 0.0163 0.0249
Loa Loa (eye worm) hypothetical protein 0.0034 0.0436 0.0436
Brugia malayi Importin beta-1 subunit 0.0029 0.0249 0.0249
Schistosoma mansoni hypothetical protein 0.0034 0.0421 0.0421
Echinococcus granulosus importin subunit beta 1 0.0029 0.0249 0.0249
Onchocerca volvulus 0.0034 0.0436 0.3563
Loa Loa (eye worm) hypothetical protein 0.0034 0.0408 0.0408
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0025 0.0128 0.0165
Loa Loa (eye worm) hypothetical protein 0.005 0.0938 0.0938
Brugia malayi SH2 domain containing protein 0.0034 0.0436 0.0436
Echinococcus multilocularis ribosomal protein L19 0.0026 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0034 0.0436 0.0436
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0128 0.0128
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0025 0.0128 0.0472
Loa Loa (eye worm) TK/ABL protein kinase 0.0044 0.0754 0.0754
Brugia malayi Variant SH3 domain containing protein 0.0034 0.0436 0.0436
Loa Loa (eye worm) hypothetical protein 0.0034 0.0408 0.0408
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0408 0.0625
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0128 0.0196
Echinococcus granulosus tensin 0.0034 0.0436 0.0436
Trypanosoma cruzi target of rapamycin kinase 3 0.0025 0.0128 0.0196
Entamoeba histolytica SH2 domain containing protein 0.0034 0.0436 0.0562
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0076 0.1801 0.2757
Schistosoma mansoni GTPase activating protein 0.0034 0.0436 0.0436
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0188 0.0188
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0071 0.0108
Onchocerca volvulus LIM and SH3 domain protein homolog 0.0034 0.0408 0.316
Echinococcus multilocularis NCK adaptor protein 0.0068 0.154 0.154
Onchocerca volvulus 0.0034 0.0408 0.316
Schistosoma mansoni apoptosis stimulating of P53 0.0034 0.0408 0.0408
Entamoeba histolytica unconventional myosin IB 0.0034 0.0408 0.0526
Echinococcus multilocularis tyrosine protein kinase Srms 0.0292 0.8897 0.8897
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0025 0.0128 0.0128
Echinococcus multilocularis endophilin A3 0.0034 0.0408 0.0408
Brugia malayi RhoGAP domain containing protein 0.0034 0.0436 0.0436
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0188 0.0188
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.138 0.138
Brugia malayi cytokine inducible SH2-containing protein 5 0.0034 0.0436 0.0436
Echinococcus granulosus src region 0.0034 0.0408 0.0408
Brugia malayi tRNA modification GTPase TrmE family protein 0.0034 0.0436 0.0436
Brugia malayi SH2 domain containing protein 0.0034 0.0436 0.0436
Loa Loa (eye worm) hypothetical protein 0.0034 0.0436 0.0436
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0292 0.8897 0.8897
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0025 0.0128 0.0472
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0032 0.0349 0.0349
Giardia lamblia GTOR 0.0025 0.0128 0.0448
Schistosoma mansoni cell polarity protein 0.0034 0.0408 0.0408
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0025 0.0128 0.0128
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0035 0.0452 0.0452
Onchocerca volvulus 0.0044 0.0754 0.8124
Loa Loa (eye worm) TK/FER protein kinase 0.0044 0.0754 0.0754
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0025 0.0128 0.0709
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0034 0.0436 0.0436
Echinococcus multilocularis epidermal growth factor receptor kinase 0.0034 0.0408 0.0408
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0034 0.0436 0.0436
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0071 0.0108
Echinococcus granulosus SH2 motif 0.0034 0.0436 0.0436
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0292 0.8897 0.8897
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0025 0.0128 0.0709
Echinococcus multilocularis ribosomal protein L19 0.0026 0.0163 0.0163
Echinococcus granulosus survival motor neuron protein 1 0.0236 0.705 0.705
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0249 0.1384
Loa Loa (eye worm) protein-tyrosine kinase 0.0034 0.0408 0.0408
Brugia malayi SH2 domain containing protein 0.0034 0.0436 0.0436
Entamoeba histolytica hypothetical protein, conserved 0.0034 0.0408 0.0526
Loa Loa (eye worm) hypothetical protein 0.0034 0.0436 0.0436
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0274 0.8304 0.8304
Trypanosoma brucei 60S ribosomal protein L19, putative 0.0026 0.0163 0.0903
Echinococcus granulosus nostrin 0.0034 0.0408 0.0408
Echinococcus granulosus N chimaerin 0.0034 0.0436 0.0436
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0034 0.0436 0.0436
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0068 0.154 0.154
Trichomonas vaginalis 60S ribosomal protein L19, putative 0.0026 0.0163 0.0249
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0144 0.4028 0.4028
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0032 0.0349 0.0534
Echinococcus multilocularis breast cancer anti estrogen resistance protein 0.0034 0.0408 0.0408
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.021 0.6205 0.799
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0128 0.0196
Brugia malayi SH2 domain containing protein 0.0034 0.0436 0.0436
Schistosoma mansoni hypothetical protein 0.0034 0.0436 0.0436
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0066 0.1473 0.2255
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.3215 0.3215
Echinococcus multilocularis tyrosine protein kinase shark 0.0044 0.0754 0.0754
Loa Loa (eye worm) TK protein kinase 0.0292 0.8897 0.8897
Echinococcus multilocularis 0.0034 0.0436 0.0436
Brugia malayi Protein kinase domain containing protein 0.0044 0.0754 0.0754
Schistosoma mansoni tensin-related 0.0034 0.0436 0.0436
Leishmania major phosphatidylinositol 3-kinase, putative 0.0025 0.0128 0.0472
Brugia malayi Variant SH3 domain containing protein 0.0034 0.0408 0.0408
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0128 0.0196
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0025 0.0128 0.0165
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.138 0.138
Echinococcus multilocularis rho guanine nucleotide exchange factor 7 0.0034 0.0408 0.0408
Brugia malayi SH2 domain containing protein 0.0034 0.0436 0.0436
Echinococcus multilocularis growth factor receptor bound protein 2 0.0068 0.154 0.154
Trypanosoma cruzi 60S ribosomal protein L19, putative 0.0026 0.0163 0.0249
Entamoeba histolytica protein kinase, putative 0.0034 0.0436 0.0562
Loa Loa (eye worm) SH2 domain-containing protein 0.0034 0.0436 0.0436
Loa Loa (eye worm) hypothetical protein 0.0034 0.0436 0.0436
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0128 0.0196
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0274 0.8304 0.8304
Echinococcus granulosus lamin 0.0027 0.0188 0.0188

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) Agonist activity at dopamine D1 receptor (unknown origin) transfected in CHO cell membranes assessed as increase in cAMP level after 8 mins by flash plate assay in presence of dopamine ChEMBL. 23333208
IC50 (functional) = 380 nM Antagonist activity at dopamine D2 receptor (unknown origin) transfected in CHO cell membranes assessed as inhibition of forskolin-stimulated cAMP level after 10 mins by flash plate assay in presence of dopamine ChEMBL. 23333208
Ki (binding) = 101 nM Displacement of [3H]N-methylspiperone from dopamine D2 receptor (unknown origin) expressed in CHO cell membranes after 60 mins ChEMBL. 23333208
Ki (binding) = 244 nM Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 mins ChEMBL. 23333208

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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