Detailed information for compound 173439

Basic information

Technical information
  • TDR Targets ID: 173439
  • Name: 1-[(3,4-dichlorophenyl)methyl]-3-isoquinolin- 5-ylurea
  • MW: 346.211 | Formula: C17H13Cl2N3O
  • H donors: 2 H acceptors: 2 LogP: 3.86 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cccc2c1ccnc2)NCc1ccc(c(c1)Cl)Cl
  • InChi: 1S/C17H13Cl2N3O/c18-14-5-4-11(8-15(14)19)9-21-17(23)22-16-3-1-2-12-10-20-7-6-13(12)16/h1-8,10H,9H2,(H2,21,22,23)
  • InChiKey: FPXVGKUJIUMJOK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[(3,4-dichlorophenyl)methyl]-3-(5-isoquinolyl)urea
  • 1-[(3,4-dichlorophenyl)methyl]-3-isoquinolin-5-yl-urea
  • 1-(3,4-dichlorobenzyl)-3-(5-isoquinolyl)urea
  • 3-[(3,4-dichlorophenyl)methyl]-1-isoquinolin-5-ylurea
  • 3-[(3,4-dichlorophenyl)methyl]-1-(5-isoquinolyl)urea
  • 3-(3,4-dichlorobenzyl)-1-(5-isoquinolyl)urea
  • 3-[(3,4-dichlorophenyl)methyl]-1-isoquinolin-5-yl-urea

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens transient receptor potential cation channel, subfamily V, member 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis serotonin receptor 0.0011 0.0013 0.0006
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0006 0.0009
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.002
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0054 0.0114
Loa Loa (eye worm) hypothetical protein 0.0016 0.0054 0.0084
Onchocerca volvulus 0.0016 0.0054 0.0065
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0051 0.0045
Loa Loa (eye worm) hypothetical protein 0.0016 0.0054 0.0084
Schistosoma mansoni amine GPCR 0.0011 0.0013 0.0003
Plasmodium falciparum E3 ubiquitin-protein ligase RNF5, putative 0.0016 0.0054 0.0008
Loa Loa (eye worm) hypothetical protein 0.0016 0.0054 0.0084
Echinococcus multilocularis g-protein coupled receptor 0.0011 0.0013 0.0006
Schistosoma mansoni fusion 0.0322 0.2244 0.232
Giardia lamblia Protein 21.1 0.0016 0.0054 1
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0322 0.2244 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0011 0.0013 0.0006
Schistosoma mansoni amine GPCR 0.0011 0.0013 0.0003
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0054 0.0114
Echinococcus multilocularis zinc finger protein Ran binding 0.0322 0.2244 0.2239
Brugia malayi Smad1 0.0016 0.0051 0.008
Brugia malayi neuropeptide F receptor 0.0011 0.0013 0.002
Echinococcus multilocularis Smad4 0.0016 0.0051 0.0045
Echinococcus granulosus tachykinin peptides receptor 99D 0.0011 0.0013 0.0006
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0029 0.0045
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0322 0.2244 0.3444
Echinococcus multilocularis g protein coupled receptor 0.0011 0.0013 0.0006
Echinococcus granulosus 7tm_1 domain containing protein 0.0011 0.0013 0.0006
Giardia lamblia Protein 21.1 0.0016 0.0054 1
Brugia malayi brahma associated protein 60 kDa 0.0904 0.6422 1
Onchocerca volvulus 0.0016 0.0054 0.0065
Echinococcus granulosus alpha 1A adrenergic receptor 0.0011 0.0013 0.0006
Leishmania major hypothetical protein, conserved 0.0016 0.0054 0.0114
Schistosoma mansoni mind bomb 0.0016 0.0054 0.0046
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0012 0.0021 0.0014
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0054 0.0114
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0904 0.6422 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.002
Loa Loa (eye worm) hypothetical protein 0.0016 0.0054 0.0084
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0051 0.0045
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0011 0.0013 0.0006
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0013 0.0006
Schistosoma mansoni alpha-1 adrenergic receptor 0.0011 0.0013 0.0003
Mycobacterium ulcerans hypothetical protein 0.0036 0.0192 0.491
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0192 0.0185
Loa Loa (eye worm) beta-lactamase 0.0036 0.0192 0.0299
Brugia malayi hypothetical protein 0.0011 0.0013 0.002
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0192 0.0736
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0013 0.0006
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0054 0.0114
Trypanosoma brucei hypothetical protein, conserved 0.0322 0.2244 1
Schistosoma mansoni RNA binding protein 0.0322 0.2244 0.232
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.002
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0013 0.0003
Brugia malayi hypothetical protein 0.0016 0.0054 0.0084
Echinococcus multilocularis dnaJ subfamily B 0.0398 0.2794 0.2789
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0012 0.0021 0.0012
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.002
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0112 0.01
Brugia malayi hypothetical protein 0.0011 0.0013 0.002
Echinococcus multilocularis SWI:SNF matrix associated 0.0904 0.6422 0.642
Echinococcus multilocularis neuropeptide receptor 0.0011 0.0013 0.0006
Loa Loa (eye worm) hypothetical protein 0.0016 0.0054 0.0084
Loa Loa (eye worm) hypothetical protein 0.0205 0.141 0.2195
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0112 0.0377
Echinococcus granulosus serotonin receptor 0.0011 0.0013 0.0006
Schistosoma mansoni smad 0.0016 0.0051 0.0043
Brugia malayi hypothetical protein 0.0016 0.0054 0.0084
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0054 0.0114
Plasmodium vivax E3 ubiquitin-protein ligase RNF5, putative 0.0016 0.0054 0.0008
Echinococcus multilocularis voltage gated potassium channel 0.0015 0.0047 0.0041
Echinococcus granulosus G protein coupled receptor 139 0.0011 0.0013 0.0006
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0049 0.0089
Echinococcus granulosus g protein coupled receptor 0.0011 0.0013 0.0006
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0012 0.0021 0.0012
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0153 0.0149
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0013 0.0003
Trichomonas vaginalis cell cycle control protein cwf24, putative 0.0016 0.0054 0.0052
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0012 0.0021 0.0012
Giardia lamblia Protein 21.1 0.0016 0.0054 1
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0054 0.0052
Brugia malayi SWIB/MDM2 domain containing protein 0.0904 0.6422 1
Mycobacterium tuberculosis Conserved protein 0.0036 0.0192 0.0943
Trypanosoma brucei hypothetical protein, conserved 0.0322 0.2244 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.002
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0322 0.2244 1
Echinococcus multilocularis E3 ubiquitin protein ligase Bre1 0.0016 0.0054 0.0048
Giardia lamblia Protein 21.1 0.0016 0.0054 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0192 0.0267
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0325 0.0433
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0153 0.0146
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0011 0.0013 0.0006
Brugia malayi YY1-associated factor 2 0.0322 0.2244 0.3494
Giardia lamblia Protein 21.1 0.0016 0.0054 1
Toxoplasma gondii zinc finger, C3HC4 type (RING finger) domain-containing protein 0.0016 0.0054 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0054 0.0052
Brugia malayi hypothetical protein 0.0016 0.0054 0.0084
Leishmania major hypothetical protein, conserved 0.0016 0.0054 0.0114
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.0033
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0049 0.0089
Mycobacterium tuberculosis Conserved protein 0.0036 0.0192 0.0943
Schistosoma mansoni hypothetical protein 0.0011 0.0013 0.0003
Brugia malayi hypothetical protein 0.0016 0.0054 0.0084
Trypanosoma cruzi WLM domain containing protein, putative 0.0322 0.2244 1
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0016 0.0054 0.0052
Echinococcus granulosus fmrfamide receptor 0.0011 0.0013 0.0006
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0112 0.01
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0015 0.0047 0.0041
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0054 0.0052
Echinococcus multilocularis dro:myosuppressin receptor 0.0011 0.0013 0.0006
Schistosoma mansoni growth hormone secretagogue receptor 0.0011 0.0013 0.0003
Schistosoma mansoni amine GPCR 0.0011 0.0013 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0054 0.0052
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0054 0.0052
Brugia malayi isocitrate dehydrogenase 0.0016 0.0049 0.0076
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.002
Echinococcus multilocularis 0.0016 0.0054 0.0048
Brugia malayi Dopamine receptor 0.0011 0.0013 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0054 0.0052
Onchocerca volvulus 0.0235 0.162 0.2508
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0361 0.1499
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0137 0.0214
Echinococcus granulosus zinc finger protein Ran binding 0.0322 0.2244 0.2239
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0044 0.0249 0.0243
Schistosoma mansoni hypothetical protein 0.0904 0.6422 0.666
Echinococcus multilocularis G-protein coupled receptor, putative 0.0011 0.0013 0.0006
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0013 0.0003
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0153 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0054 0.0052
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0188 0.0181
Loa Loa (eye worm) hypothetical protein 0.0322 0.2244 0.3494
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0012 0.0021 0.0014
Echinococcus granulosus hyperpolarization activated cyclic 0.0012 0.0021 0.0014
Giardia lamblia Protein 21.1 0.0016 0.0054 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0234 0.1615 0.2515
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0013 0.0006
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0054 0.0114
Onchocerca volvulus 0.0036 0.0192 0.028
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0054 0.0052
Schistosoma mansoni ring finger protein 151 0.0016 0.0054 0.0046
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0275 0.0276
Echinococcus granulosus neuropeptide s receptor 0.0459 0.3226 0.3222
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0192 0.5
Brugia malayi Serotonin receptor 0.0011 0.0013 0.002
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0051 0.008
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0011 0.0013 0.0006
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0051 0.0045
Toxoplasma gondii hypothetical protein 0.0016 0.0054 0.0008
Leishmania major hypothetical protein, conserved 0.0016 0.0054 0.0114
Schistosoma mansoni hypothetical protein 0.0011 0.0013 0.0003
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0054 0.0114
Brugia malayi G protein-coupled receptor 0.0011 0.0013 0.002
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0054 0.0114
Giardia lamblia Ser/Thr protein kinase 0.0016 0.0054 1
Schistosoma mansoni hypothetical protein 0.0165 0.112 0.1154
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.002
Toxoplasma gondii hypothetical protein 0.0016 0.0054 0.0008
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0011 0.0013 0.0006
Loa Loa (eye worm) hypothetical protein 0.0016 0.0054 0.0084
Leishmania major hypothetical protein, conserved 0.0322 0.2244 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0011 0.0013 0.0003
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0013 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0054 0.0052
Loa Loa (eye worm) hypothetical protein 0.0015 0.0047 0.0073
Brugia malayi Dopamine receptor protein 2 0.0011 0.0013 0.002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0013 0.0003
Echinococcus granulosus geminin 0.0165 0.112 0.1115
Echinococcus granulosus biogenic amine 5HT receptor 0.0011 0.0013 0.0006
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0011 0.0013 0.0006
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0051 0.008
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0322 0.2244 0.3494
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0011 0.0013 0.0003
Schistosoma mansoni hypothetical protein 0.0016 0.0054 0.0046
Plasmodium falciparum trophozoite exported protein 1 0.0016 0.0054 0.0008
Trypanosoma brucei Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0054 0.0114
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.002
Toxoplasma gondii Bardet-Biedl syndrome 5, putative 0.0016 0.0054 0.0008
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0192 0.0225
Onchocerca volvulus 0.0036 0.0192 0.028
Schistosoma mansoni inhibitor of apoptosis 1 diap1 0.0016 0.0054 0.0046
Plasmodium falciparum zinc finger protein, putative 0.0016 0.0054 0.0008
Schistosoma mansoni hypothetical protein 0.0011 0.0013 0.0003
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0016 0.0054 0.0052
Trichomonas vaginalis ankyrin repeat domain protein, putative 0.0016 0.0054 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0054 0.0052
Brugia malayi MH2 domain containing protein 0.0016 0.0051 0.008
Loa Loa (eye worm) Smad1 0.0016 0.0051 0.008
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.0013 0.0006
Giardia lamblia Protein 21.1 0.0016 0.0054 1
Schistosoma mansoni zinc finger protein 0.0016 0.0054 0.0046
Schistosoma mansoni neuropeptide receptor 0.0011 0.0013 0.0003
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0904 0.6422 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0051 0.0045
Brugia malayi follicle stimulating hormone receptor 0.0011 0.0013 0.002
Trypanosoma brucei DNA repair protein, putative 0.0016 0.0054 0.0114
Leishmania major hypothetical protein, unknown function 0.0016 0.0054 0.0114
Trichomonas vaginalis ankyrin, putative 0.0016 0.0054 0.0052
Schistosoma mansoni cpg binding protein 0.003 0.0149 0.0145
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0054 0.0052
Schistosoma mansoni hypothetical protein 0.0011 0.0013 0.0003
Toxoplasma gondii ran binding protein 0.0322 0.2244 0.3444
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0275 0.0276
Giardia lamblia Protein 21.1 0.0016 0.0054 1
Toxoplasma gondii hypothetical protein 0.0016 0.0054 0.0008
Giardia lamblia Protein 21.1 0.0016 0.0054 1
Echinococcus multilocularis geminin 0.0165 0.112 0.1115
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0012 0.0021 0.0012
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.002
Echinococcus multilocularis hyperpolarization activated cyclic 0.0012 0.0021 0.0014
Plasmodium falciparum RING zinc finger protein, putative 0.0016 0.0054 0.0008
Trypanosoma brucei SNF2 family N-terminal domain/Ring finger domain containing protein, putative 0.0016 0.0054 0.0114
Onchocerca volvulus 0.0322 0.2244 0.3481
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.002
Echinococcus granulosus somatostatin receptor 0.0011 0.0013 0.0006
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.0013 0.0006
Loa Loa (eye worm) G-protein coupled receptor 0.0011 0.0013 0.002
Echinococcus granulosus SWI:SNF matrix associated 0.0904 0.6422 0.642
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0188 0.0181
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0054 0.0114
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0054 0.0052
Giardia lamblia Protein 21.1 0.0016 0.0054 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0049 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0054 0.0052
Echinococcus multilocularis neuropeptide Y receptor 0.0011 0.0013 0.0006
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.002
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0044 0.0249 0.0243
Leishmania major hypothetical protein, conserved 0.0016 0.0054 0.0114
Echinococcus multilocularis microtubule associated protein 2 0.1353 0.9638 0.9638
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.002
Echinococcus multilocularis ring and YY1 binding protein 0.0322 0.2244 0.2239
Leishmania major hypothetical protein, conserved 0.0016 0.0054 0.0114
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.002
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0012 0.0021 0.0014
Schistosoma mansoni smad1 5 8 and 0.0016 0.0051 0.0043
Echinococcus multilocularis orexin receptor type 2 0.0011 0.0013 0.0006
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0013 0.0006
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0361 0.0355
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0322 0.2244 0.3481
Brugia malayi hypothetical protein 0.0011 0.0013 0.002
Schistosoma mansoni biogenic amine receptor 0.0011 0.0013 0.0003
Echinococcus granulosus ring finger protein 170 0.0016 0.0054 0.0048
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.0013 0.0006
Leishmania major hypothetical protein, conserved 0.0016 0.0054 0.0114
Schistosoma mansoni neuropeptide F-like receptor 0.0011 0.0013 0.0003
Leishmania major hypothetical protein, conserved 0.0322 0.2244 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0192 0.0299
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0013 0.0006
Onchocerca volvulus 0.0322 0.2244 0.3481
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0013 0.0006
Echinococcus multilocularis neuropeptide s receptor 0.0459 0.3226 0.3222
Giardia lamblia Protein 21.1 0.0016 0.0054 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.002
Chlamydia trachomatis SWIB complex protein 0.0904 0.6422 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0013 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0054 0.0052
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.0054 0.0046
Echinococcus multilocularis neuropeptide receptor 0.0011 0.0013 0.0006
Brugia malayi hypothetical protein 0.0011 0.0013 0.002
Echinococcus multilocularis SWI:SNF matrix associated 0.0904 0.6422 0.642
Brugia malayi hypothetical protein 0.0011 0.0013 0.002
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0011 0.0013 0.002
Giardia lamblia Protein 21.1 0.0016 0.0054 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.0202 0.0283
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.002
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0044 0.0249 0.0388
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0044 0.0249 0.0388
Schistosoma mansoni hypothetical protein 0.0016 0.0054 0.0046
Echinococcus granulosus ring finger protein 113a 0.0016 0.0054 0.0048
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0141 0.0134
Echinococcus multilocularis tumor protein p63 0.1403 1 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0361 1
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0361 0.0365
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0013 0.0006
Brugia malayi MH2 domain containing protein 0.0234 0.1615 0.2515
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0011 0.0013 0.0003
Brugia malayi Pre-SET motif family protein 0.003 0.0153 0.0238
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.002
Schistosoma mansoni peter pan-related 0.0016 0.0054 0.0046
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0361 0.0355
Trichomonas vaginalis hypothetical protein 0.0016 0.0054 0.0052
Echinococcus multilocularis neuropeptide FF receptor 2 0.0011 0.0013 0.0006
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0016 0.0009
Schistosoma mansoni peter pan-related 0.0016 0.0054 0.0046
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0904 0.6422 0.642
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.002
Chlamydia trachomatis DNA topoisomerase I 0.0904 0.6422 0.5
Giardia lamblia Protein 21.1 0.0016 0.0054 1
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0192 0.0943
Onchocerca volvulus RING finger protein 141 homolog 0.0016 0.0054 0.0065
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0054 0.0114
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0192 0.0267
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0054 0.0052
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0361 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0192 0.0267
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0322 0.2244 1
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0054 0.0114
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0192 0.0943
Leishmania major hypothetical protein, conserved 0.0016 0.0054 0.0114
Brugia malayi neuropeptide F receptor 0.0011 0.0013 0.002
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0015 0.0047 0.0041
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0013 0.0003
Echinococcus multilocularis cpg binding protein 0.003 0.0149 0.0142
Toxoplasma gondii RING zinc finger protein 0.0016 0.0054 0.0008
Schistosoma mansoni neuropeptide F-like receptor 0.0011 0.0013 0.0003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0153 0.0149
Echinococcus granulosus E3 ubiquitin protein ligase LRSAM1 0.0016 0.0054 0.0048
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0016 0.0054 0.0052
Echinococcus granulosus g protein coupled receptor 0.0011 0.0013 0.0006
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0011 0.0013 0.0006
Loa Loa (eye worm) histone methyltransferase 0.001 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.0322 0.2244 0.3494
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0322 0.2244 0.3494
Loa Loa (eye worm) hypothetical protein 0.0036 0.0192 0.0299
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0049 0.0042
Onchocerca volvulus 0.0904 0.6422 1
Brugia malayi G-protein coupled receptor 0.0011 0.0013 0.002
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0012 0.0021 0.0014
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0054 0.0114
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0192 0.0736
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0054 0.0114
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.002
Brugia malayi brahma associated protein 60 kDa 0.0904 0.6422 1
Trichomonas vaginalis conserved hypothetical protein 0.0904 0.6422 1
Trichomonas vaginalis ankyrin, putative 0.0016 0.0054 0.0052
Brugia malayi MH1 domain containing protein 0.0016 0.0051 0.008
Echinococcus multilocularis ring finger protein 113a 0.0016 0.0054 0.0048
Brugia malayi AKH receptor 0.0011 0.0013 0.002
Schistosoma mansoni hypothetical protein 0.0035 0.0188 0.0185
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative 0.0016 0.0054 0.0114
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.002
Loa Loa (eye worm) neuropeptide F receptor 0.0011 0.0013 0.002
Schistosoma mansoni voltage-gated potassium channel 0.0015 0.0047 0.0039
Brugia malayi RE15519p 0.0011 0.0013 0.002
Schistosoma mansoni neuropeptide receptor 0.0011 0.0013 0.0003
Echinococcus granulosus cell growth regulator with ring finger domain 0.0016 0.0054 0.0048
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0054 0.0114
Loa Loa (eye worm) neuropeptide F receptor 0.0011 0.0013 0.002
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0192 0.491
Echinococcus multilocularis neuropeptide receptor A26 0.0459 0.3226 0.3222
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0192 0.0943
Brugia malayi hypothetical protein 0.0024 0.0112 0.0175
Echinococcus granulosus neuropeptide Y receptor 0.0011 0.0013 0.0006
Onchocerca volvulus 0.0016 0.0054 0.0065
Brugia malayi Zinc finger protein 183 homolog 0.0016 0.0054 0.0084
Toxoplasma gondii hypothetical protein 0.0016 0.0054 0.0008
Onchocerca volvulus 0.0147 0.0992 0.1528
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0153 0.0146
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0011 0.0013 0.0003
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0011 0.0013 0.002
Toxoplasma gondii zinc finger, C3HC4 type (RING finger) domain-containing protein 0.0016 0.0054 0.0008
Mycobacterium tuberculosis Conserved protein 0.0036 0.0192 0.0943
Onchocerca volvulus Putative RING finger protein 207 0.0016 0.0054 0.0065
Echinococcus multilocularis E3 ubiquitin protein ligase mib1 0.0016 0.0054 0.0048
Toxoplasma gondii SWI2/SNF2-containing protein RAD5 0.0016 0.0054 0.0008
Mycobacterium ulcerans lipase LipD 0.0036 0.0192 0.491
Echinococcus multilocularis somatostatin receptor 0.0011 0.0013 0.0006
Plasmodium vivax DNA repair protein RAD5, putative 0.0016 0.0054 0.0008
Brugia malayi MH1 domain containing protein 0.0016 0.0051 0.008
Trypanosoma cruzi WLM domain containing protein, putative 0.0322 0.2244 1
Trypanosoma brucei ring finger containing protein 0.0016 0.0054 0.0114
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.002
Brugia malayi Serotonin receptor 0.0011 0.0013 0.002
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0054 0.0114
Echinococcus granulosus ring and YY1 binding protein 0.0322 0.2244 0.2239
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0361 1
Brugia malayi G-protein coupled receptor 0.0011 0.0013 0.002
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.079 0.5601 0.5598
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0361 0.049
Brugia malayi ORL1-like opioid receptor 0.0011 0.0013 0.002
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0322 0.2244 0.3494
Plasmodium vivax SET domain protein, putative 0.003 0.0153 0.0163
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0011 0.0013 0.0006
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0054 0.0114
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.002
Schistosoma mansoni rnf5 0.0016 0.0054 0.0046
Brugia malayi G protein-coupled receptor F59B2.13 0.0011 0.0013 0.002
Loa Loa (eye worm) hypothetical protein 0.0038 0.0211 0.0329
Echinococcus multilocularis E3 ubiquitin protein ligase LRSAM1 0.0016 0.0054 0.0048
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.002
Leishmania major hypothetical protein, conserved 0.0016 0.0054 0.0114
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0054 0.0052
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0049 0.0076
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0054 0.0114
Trypanosoma cruzi hypothetical protein, conserved 0.0322 0.2244 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0112 0.0175
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.0013 0.0003
Brugia malayi beta-lactamase family protein 0.0036 0.0192 0.0299
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.002
Brugia malayi Dopamine receptor protein 1 0.0011 0.0013 0.002
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0054 0.0114
Giardia lamblia Protein 21.1 0.0016 0.0054 1
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0904 0.6422 1
Schistosoma mansoni microtubule-associated protein tau 0.1353 0.9638 1
Loa Loa (eye worm) hypothetical protein 0.0322 0.2244 0.3494
Brugia malayi GnHR receptor homolog 0.0011 0.0013 0.002
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0051 0.0043
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative 0.0016 0.0054 0.0114
Loa Loa (eye worm) RING finger protein 20 0.0016 0.0054 0.0084
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0011 0.0013 0.002
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0012 0.0021 0.0033
Trypanosoma cruzi hypothetical protein, conserved 0.0322 0.2244 1
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0054 0.0114
Giardia lamblia Protein 21.1 0.0016 0.0054 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0011 0.0013 0.0006
Schistosoma mansoni voltage-gated potassium channel 0.0012 0.0021 0.0012
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.0013 0.0003
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0227 0.1567 1
Giardia lamblia Protein 21.1 0.0016 0.0054 1
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0012 0.0021 0.0014
Entamoeba histolytica hypothetical protein 0.0035 0.0188 1
Brugia malayi RING finger protein 20 0.0016 0.0054 0.0084
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0013 0.0006
Trypanosoma cruzi hypothetical protein 0.0016 0.0054 0.0114
Schistosoma mansoni amine GPCR 0.0011 0.0013 0.0003
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0013 0.0006
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0904 0.6422 1
Brugia malayi putative neuropeptide receptor 0.0011 0.0013 0.002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0013 0.0006
Brugia malayi hypothetical protein 0.0016 0.0054 0.0084
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0054 0.0114
Leishmania major hypothetical protein, conserved 0.0016 0.0054 0.0114
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0049 0.0089
Echinococcus multilocularis RING finger and transmembrane domain containing protein 0.0016 0.0054 0.0048
Leishmania major hypothetical protein, conserved 0.0016 0.0054 0.0114
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0011 0.0013 0.0006
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.002
Echinococcus granulosus E3 ubiquitin protein ligase MYLIP 0.0016 0.0054 0.0048
Brugia malayi Cytochrome P450 family protein 0.0013 0.0029 0.0045
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0153 0.0146
Leishmania major hypothetical protein, conserved 0.0024 0.0112 0.0377
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0054 0.0114
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.0013 0.0003
Schistosoma mansoni neuropeptide f receptor 76f 0.0011 0.0013 0.0003
Leishmania major hypothetical protein, conserved 0.0016 0.0054 0.0114
Echinococcus granulosus hyperpolarization activated cyclic 0.0012 0.0021 0.0014
Schistosoma mansoni smad1 5 8 and 0.0016 0.0051 0.0043
Loa Loa (eye worm) hypothetical protein 0.0016 0.0054 0.0084
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0054 0.0114
Brugia malayi Pre-SET motif family protein 0.0206 0.1416 0.2205
Brugia malayi putative neuropeptide receptor NPR1 0.0011 0.0013 0.002
Brugia malayi sulfakinin receptor protein 0.0011 0.0013 0.002
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.002
Trypanosoma cruzi Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0054 0.0114
Giardia lamblia Protein 21.1 0.0016 0.0054 1
Plasmodium vivax hypothetical protein, conserved 0.0904 0.6422 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0013 0.0003
Brugia malayi CXXC zinc finger family protein 0.0028 0.0137 0.0214
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0322 0.2244 0.3494
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0188 0.0185
Plasmodium falciparum E3 ubiquitin-protein ligase, putative 0.0016 0.0054 0.0008
Loa Loa (eye worm) hypothetical protein 0.0147 0.0992 0.1545
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0054 0.0114
Onchocerca volvulus 0.0016 0.0054 0.0065
Schistosoma mansoni neuropeptide receptor 0.0011 0.0013 0.0003
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0011 0.0013 0.0003
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.002
Echinococcus multilocularis g protein coupled receptor 0.0011 0.0013 0.0006
Leishmania major hypothetical protein, conserved 0.0036 0.0192 0.0736
Plasmodium vivax E3 ubiquitin-protein ligase, putative 0.0016 0.0054 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0054 0.0052
Schistosoma mansoni cpg binding protein 0.0028 0.0137 0.0133
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0049 0.0042
Echinococcus granulosus neuropeptide receptor A26 0.0459 0.3226 0.3222
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0049 0.0042
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.0013 0.0006
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0011 0.0013 0.0006
Schistosoma mansoni biogenic amine (5HT) receptor 0.0011 0.0013 0.0003
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.002
Onchocerca volvulus Protein neuralized homolog 0.0016 0.0054 0.0065
Toxoplasma gondii ABC1 family protein 0.0036 0.0192 0.0225
Loa Loa (eye worm) hypothetical protein 0.0016 0.0054 0.0084
Echinococcus multilocularis neuropeptides capa receptor 0.0011 0.0013 0.0006
Brugia malayi hypothetical protein 0.0011 0.0013 0.002
Schistosoma mansoni hypothetical protein 0.0904 0.6422 0.666
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0011 0.0013 0.0006
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0192 0.0267
Echinococcus multilocularis E3 ubiquitin protein ligase MYLIP 0.0016 0.0054 0.0048
Leishmania major hypothetical protein, conserved 0.0322 0.2244 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0011 0.0013 0.002
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.002
Brugia malayi Zinc finger, C2H2 type family protein 0.0016 0.0054 0.0084
Loa Loa (eye worm) brahma associated protein 0.0904 0.6422 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0192 0.0267
Schistosoma mansoni Smad4 0.0016 0.0051 0.0043
Mycobacterium leprae Probable lipase LipE 0.0036 0.0192 0.5
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.002
Giardia lamblia Protein 21.1 0.0016 0.0054 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0192 0.0299
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0054 0.0052
Trichomonas vaginalis ankyrin, putative 0.0016 0.0054 0.0052
Echinococcus granulosus 7TM GPCR rhodopsin 0.0011 0.0013 0.0006
Loa Loa (eye worm) CYP4Cod1 0.0013 0.0029 0.0045
Echinococcus multilocularis hyperpolarization activated cyclic 0.0012 0.0021 0.0014
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.0013 0.0006
Schistosoma mansoni amine GPCR 0.0011 0.0013 0.0003
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0012 0.0021 0.0014
Loa Loa (eye worm) hypothetical protein 0.0016 0.0054 0.0084
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0361 0.2056
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0049 0.0076
Echinococcus multilocularis fmrfamide receptor 0.0011 0.0013 0.0006
Echinococcus granulosus Zinc finger RanBP2 type 0.0322 0.2244 0.2239
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0049 0.0042
Trichomonas vaginalis esterase, putative 0.0036 0.0192 0.0267
Brugia malayi hypothetical protein 0.0147 0.0992 0.1545
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.002
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0054 0.0114
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.037 0.0374
Plasmodium vivax trophozoite exported protein 1, putative 0.0016 0.0054 0.0008
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.0013 0.0006
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.002
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0011 0.0013 0.0006
Trichomonas vaginalis set domain proteins, putative 0.0235 0.162 0.2498
Echinococcus granulosus RING finger protein 185 0.0016 0.0054 0.0048
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.002
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0054 0.0114
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0054 0.0052
Schistosoma mansoni hypothetical protein 0.0322 0.2244 0.232
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0322 0.2244 1
Brugia malayi hypothetical protein 0.0011 0.0013 0.002
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0012 0.0021 0.0014
Echinococcus multilocularis smad 0.0016 0.0051 0.0045
Leishmania major hypothetical protein, conserved 0.0322 0.2244 1
Leishmania major hypothetical protein 0.0016 0.0054 0.0114
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0011 0.0013 0.0003
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0112 0.01
Leishmania major DNA repair protein-like protein 0.0016 0.0054 0.0114
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0054 0.0052
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0322 0.2244 1
Giardia lamblia Protein 21.1 0.0016 0.0054 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0011 0.0013 0.0006
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0013 0.0006
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0054 0.0052
Onchocerca volvulus 0.0322 0.2244 0.3481
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0011 0.0013 0.0006
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0012 0.0021 0.0033
Leishmania major hypothetical protein, conserved 0.0322 0.2244 1
Loa Loa (eye worm) G-protein coupled receptor 0.0011 0.0013 0.002
Loa Loa (eye worm) hypothetical protein 0.0322 0.2244 0.3494
Loa Loa (eye worm) hypothetical protein 0.0036 0.0192 0.0299
Schistosoma mansoni opsin-like receptor 0.0011 0.0013 0.0003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0153 0.0149
Echinococcus granulosus neuropeptide receptor 0.0011 0.0013 0.0006
Echinococcus multilocularis allatostatin A receptor 0.0011 0.0013 0.0006
Schistosoma mansoni neuropeptide receptor 0.0011 0.0013 0.0003
Echinococcus granulosus RING finger and transmembrane domain containing protein 0.0016 0.0054 0.0048
Echinococcus granulosus g-protein coupled receptor 0.0011 0.0013 0.0006
Plasmodium vivax zinc finger protein, putative 0.0016 0.0054 0.0008
Schistosoma mansoni biogenic amine (5HT) receptor 0.0011 0.0013 0.0003
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0054 0.0052
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0904 0.6422 0.642
Brugia malayi Neuralized family protein 0.0016 0.0054 0.0084
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.002
Loa Loa (eye worm) RiNg Finger protein family member 0.0016 0.0054 0.0084
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0904 0.6422 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0011 0.0013 0.002
Schistosoma mansoni histamine h1 receptor 0.0011 0.0013 0.0003
Schistosoma mansoni biogenic amine receptor 0.0011 0.0013 0.0003
Onchocerca volvulus 0.0036 0.0192 0.028
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0011 0.0013 0.002
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0015 0.0047 0.0073
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.0202 0.0283
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0049 0.0042
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0112 0.0377
Echinococcus granulosus hypothetical protein 0.0011 0.0013 0.0006
Schistosoma mansoni voltage-gated potassium channel 0.0015 0.0047 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0054 0.0052
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0049 0.0089
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0054 0.0114
Echinococcus granulosus allatostatin A receptor 0.0011 0.0013 0.0006
Brugia malayi hypothetical protein 0.0011 0.0013 0.002
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0904 0.6422 1
Plasmodium vivax RING zinc finger protein, putative 0.0016 0.0054 0.0008
Brugia malayi Cytochrome P450 family protein 0.0013 0.0029 0.0045
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0192 0.0736
Schistosoma mansoni myosin xvIII 0.0011 0.0013 0.0003
Echinococcus granulosus E3 ubiquitin protein ligase mib1 0.0016 0.0054 0.0048
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0054 0.0114
Trypanosoma brucei predicted zinc finger protein 0.0016 0.0054 0.0114
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.002
Echinococcus granulosus Smad4 0.0016 0.0051 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0054 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0054 0.0052
Loa Loa (eye worm) hypothetical protein 0.0016 0.0054 0.0084
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0054 0.0114
Echinococcus granulosus neuropeptide Y receptor 0.0011 0.0013 0.0006
Echinococcus granulosus E3 ubiquitin protein ligase RNF146 0.0016 0.0054 0.0048
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0011 0.0013 0.002
Schistosoma mansoni biogenic amine receptor 0.0011 0.0013 0.0003
Trypanosoma brucei Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0054 0.0114
Onchocerca volvulus 0.0322 0.2244 0.3481
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0112 0.01
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0192 0.0189
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.002
Echinococcus multilocularis serotonin receptor 0.0011 0.0013 0.0006
Loa Loa (eye worm) transcription factor SMAD2 0.0234 0.1615 0.2515
Echinococcus granulosus dnaJ subfamily B 0.0398 0.2794 0.2789
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0192 0.0299
Schistosoma mansoni TRABID protein (C64 family) 0.0322 0.2244 0.232
Brugia malayi beta-lactamase family protein 0.0036 0.0192 0.0299
Trypanosoma cruzi Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0054 0.0114
Giardia lamblia Protein 21.1 0.0016 0.0054 1
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0054 0.0114
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0054 0.0114
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0012 0.0021 0.0012
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0322 0.2244 0.2239
Brugia malayi hypothetical protein 0.0011 0.0013 0.002
Echinococcus granulosus neuropeptide receptor 0.0011 0.0013 0.0006
Loa Loa (eye worm) hypothetical protein 0.0036 0.0192 0.0299
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.002
Schistosoma mansoni hypothetical protein 0.0904 0.6422 0.666
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0013 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0054 0.0052
Onchocerca volvulus 0.0028 0.0137 0.0194
Schistosoma mansoni adenoreceptor 0.0011 0.0013 0.0003
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0011 0.0013 0.0003
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0011 0.0013 0.0006
Brugia malayi Hypothetical RING finger protein C16C10.7 in chromosome III 0.0016 0.0054 0.0084
Loa Loa (eye worm) hypothetical protein 0.0322 0.2244 0.3494
Brugia malayi hypothetical protein 0.0016 0.0054 0.0084
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0192 0.0299
Onchocerca volvulus 0.0016 0.0054 0.0065
Brugia malayi beta-lactamase 0.0036 0.0192 0.0299
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0011 0.0013 0.002
Giardia lamblia Protein 21.1 0.0016 0.0054 1
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0054 0.0114
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.002
Brugia malayi B-box zinc finger family protein 0.0016 0.0054 0.0084
Brugia malayi MH2 domain containing protein 0.0016 0.0051 0.008
Giardia lamblia Protein 21.1 0.0016 0.0054 1
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger) containing protein, putative 0.0016 0.0054 0.0114
Echinococcus granulosus neuropeptides capa receptor 0.0011 0.0013 0.0006
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0016 0.0009
Schistosoma mansoni hypothetical protein 0.0016 0.0054 0.0046
Trypanosoma brucei Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0054 0.0114
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0011 0.0013 0.0006
Echinococcus multilocularis RING finger protein 185 0.0016 0.0054 0.0048
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0054 0.0114
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0192 0.491
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0322 0.2244 0.2239
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0013 0.0003
Schistosoma mansoni hypothetical protein 0.0165 0.112 0.1154
Echinococcus granulosus smad 0.0016 0.0051 0.0045
Echinococcus granulosus orexin receptor type 2 0.0011 0.0013 0.0006
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0029 0.0045
Schistosoma mansoni hypothetical protein 0.0011 0.0016 0.0006
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0192 0.0943
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0192 0.0943
Giardia lamblia Protein 21.1 0.0016 0.0054 1
Brugia malayi Melatonin receptor type 1A 0.0011 0.0013 0.002
Echinococcus multilocularis ring finger protein 170 0.0016 0.0054 0.0048
Schistosoma mansoni zinc finger protein 0.0322 0.2244 0.232
Schistosoma mansoni opsin-like receptor 0.0011 0.0013 0.0003
Echinococcus granulosus g protein coupled receptor 0.0011 0.0013 0.0006
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.002
Brugia malayi Tachykinin-like peptides receptor 99D 0.0011 0.0013 0.002
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0322 0.2244 1
Echinococcus multilocularis neuropeptides capa receptor 0.0011 0.0013 0.0006
Echinococcus granulosus cpg binding protein 0.003 0.0149 0.0142
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.002
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0011 0.0013 0.0006
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0192 0.0185
Schistosoma mansoni opsin-like receptor 0.0011 0.0013 0.0003
Leishmania major hypothetical protein, conserved 0.0016 0.0054 0.0114
Trypanosoma cruzi hypothetical protein, conserved 0.0322 0.2244 1
Entamoeba histolytica hypothetical protein 0.0035 0.0188 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.002
Schistosoma mansoni brg-1 associated factor 0.0904 0.6422 0.666
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0054 0.0114
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0011 0.0013 0.002
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0054 0.0114
Echinococcus granulosus sex peptide receptor 0.0011 0.0013 0.0006
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0013 0.0006
Schistosoma mansoni smad1 5 8 and 0.0016 0.0051 0.0043
Mycobacterium ulcerans beta-lactamase 0.0036 0.0192 0.491
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0054 0.0052
Brugia malayi Cyclic-nucleotide gated cation channel 0.0012 0.0021 0.0033
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0049 0.0089
Onchocerca volvulus 0.003 0.0153 0.0218
Trichomonas vaginalis sex-determining protein fem-1, putative 0.0016 0.0054 0.0052
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.002
Echinococcus granulosus microtubule associated protein 2 0.1353 0.9638 0.9638
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0054 0.0052
Entamoeba histolytica hypothetical protein 0.0035 0.0188 1
Onchocerca volvulus 0.0205 0.141 0.218
Giardia lamblia Kinase, NEK 0.0016 0.0054 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0011 0.0013 0.0006
Entamoeba histolytica hypothetical protein 0.0035 0.0188 1
Brugia malayi hypothetical protein 0.0016 0.005 0.0078
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0011 0.0013 0.0003
Loa Loa (eye worm) hypothetical protein 0.003 0.0153 0.0238
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0054 0.0114
Echinococcus granulosus neuropeptides capa receptor 0.0011 0.0013 0.0006
Toxoplasma gondii helicase, putative 0.0016 0.0054 0.0008
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0011 0.0013 0.0006
Echinococcus granulosus voltage gated potassium channel 0.0015 0.0047 0.0041
Echinococcus granulosus E3 ubiquitin protein ligase Bre1 0.0016 0.0054 0.0048
Trypanosoma cruzi hypothetical protein 0.0016 0.0054 0.0114
Trichomonas vaginalis ion channel nompc, putative 0.0016 0.0054 0.0052
Schistosoma mansoni cpg binding protein 0.003 0.0149 0.0145
Brugia malayi hypothetical protein 0.0011 0.0013 0.002
Brugia malayi hypothetical protein 0.0035 0.0188 0.0292
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0016 0.0054 0.0052
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0054 0.0114
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0011 0.0013 0.002
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0011 0.0013 0.0003
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0322 0.2244 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0013 0.0006
Brugia malayi RING zinc finger protein 0.0016 0.0054 0.0084
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0192 0.0943
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0016 0.0054 0.0052
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0153 0.0149
Schistosoma mansoni hypothetical protein 0.0398 0.2794 0.2892
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0054 0.0052
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.002
Echinococcus multilocularis fmrfamide receptor 0.0011 0.0013 0.0006
Leishmania major hypothetical protein, conserved 0.0016 0.0054 0.0114
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0011 0.0013 0.002
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0361 0.0365
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0192 0.0189
Echinococcus multilocularis SWI:SNF matrix associated 0.0904 0.6422 0.642
Loa Loa (eye worm) hypothetical protein 0.0036 0.0192 0.0299
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0049 0.0041
Echinococcus multilocularis g protein coupled receptor 0.0011 0.0013 0.0006
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0322 0.2244 0.3444
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0192 0.0943
Echinococcus multilocularis sex peptide receptor 0.0011 0.0013 0.0006
Echinococcus multilocularis neuropeptide Y receptor 0.0011 0.0013 0.0006
Echinococcus granulosus dro:myosuppressin receptor 0.0011 0.0013 0.0006
Onchocerca volvulus 0.0016 0.0054 0.0065
Brugia malayi larval opioid receptor 0.0011 0.0013 0.002
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0112 0.0377
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0013 0.0003
Echinococcus multilocularis G protein coupled receptor 139 0.0011 0.0013 0.0006
Schistosoma mansoni cellular tumor antigen P53 0.0205 0.141 0.1454
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0322 0.2244 0.2239
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0011 0.0013 0.0003
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0016 0.0054 0.0114
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.1416 0.2205
Loa Loa (eye worm) TYRA-2 protein 0.0011 0.0013 0.002

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 4 nM Antagonistic activity towards human vanilloid receptor subtype 1 expressed in HEK293 cell membrane, as inhibition of agonist-induced intracellular [Ca2+] levels. ChEMBL. 15149643
IC50 (functional) = 4 nM Antagonistic activity towards human vanilloid receptor subtype 1 expressed in HEK293 cell membrane, as inhibition of agonist-induced intracellular [Ca2+] levels. ChEMBL. 15149643
Ki (binding) = 9 nM Binding affinity towards human vanilloid receptor subtype 1 expressed in HEK293 cell membrane using [3H]-RTX as radioligand. ChEMBL. 15149643
Ki (binding) = 9 nM Binding affinity towards human vanilloid receptor subtype 1 expressed in HEK293 cell membrane using [3H]-RTX as radioligand. ChEMBL. 15149643

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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