TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 601.689 | Formula: C29H36FN5O6S
H donors: 2 H acceptors: 5 LogP: 5.07 Rotable bonds: 10
Rule of 5 violations (Lipinski): 2
SMILES: COc1cc2nc(NC3CC4CCC(C3)N4C(=O)OC(C)(C)C)nc(c2cc1OC)Nc1ccc(cc1F)S(=O)(=O)C
InChi: 1S/C29H36FN5O6S/c1-29(2,3)41-28(36)35-17-7-8-18(35)12-16(11-17)31-27-33-23-15-25(40-5)24(39-4)14-20(23)26(34-27)32-22-10-9-19(13-21(22)30)42(6,37)38/h9-10,13-18H,7-8,11-12H2,1-6H3,(H2,31,32,33,34)
InChiKey: MALQSTLACRSJTA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	G protein-coupled receptor 119	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	follicle stimulating hormone receptor	G protein-coupled receptor 119	335 aa	274 aa	22.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	protein kinase, putative	0.0049	0.0528	0.1185
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0186	0.2618	0.2618
Schistosoma mansoni	cathepsin C	0.0043	0.0425	0.0425
Plasmodium vivax	SET domain protein, putative	0.003	0.0225	0.0273
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.147	0.3646
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0478	0.1439
Brugia malayi	Papain family cysteine protease containing protein	0.0211	0.3004	0.9163
Trypanosoma cruzi	cysteine peptidase, putative	0.0306	0.4458	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0211	0.3004	0.8992
Loa Loa (eye worm)	hypothetical protein	0.0143	0.1958	0.5966
Entamoeba histolytica	cysteine proteinase, putative	0.0111	0.147	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0306	0.4458	1
Brugia malayi	Papain family cysteine protease containing protein	0.0111	0.147	0.4474
Brugia malayi	MAP kinase sur-1	0.0049	0.0528	0.1594
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0043	0.0425	0.1277
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0143	0.1958	0.5347
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0306	0.4458	1
Loa Loa (eye worm)	cysteine protease	0.0211	0.3004	0.9163
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0043	0.0425	0.0973
Entamoeba histolytica	cysteine protease, putative	0.0111	0.147	0.4054
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0225	0.0218
Brugia malayi	cathepsin F-like cysteine proteinase	0.0043	0.0425	0.1277
Trypanosoma brucei	PAB1-binding protein , putative	0.0024	0.0147	0.0329
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0049	0.0528	0.1185
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0211	0.3004	0.8992
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0306	0.4458	1
Giardia lamblia	Cathepsin B precursor	0.0087	0.1103	1
Trichomonas vaginalis	CMGC family protein kinase	0.0049	0.0528	0.0361
Brugia malayi	Bromodomain containing protein	0.0074	0.0909	0.2758
Trypanosoma cruzi	cysteine peptidase, putative	0.0111	0.147	0.3299
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0225	0.0225
Schistosoma mansoni	hypothetical protein	0.0047	0.0488	0.0488
Plasmodium falciparum	serine repeat antigen 9	0.0043	0.0425	0.0973
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0111	0.147	0.147
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0049	0.0528	0.1185
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0043	0.0425	0.1277
Entamoeba histolytica	cysteine protease, putative	0.0211	0.3004	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0306	0.4458	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0673	0.5
Trichomonas vaginalis	CMGC family protein kinase	0.0049	0.0528	0.0361
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0087	0.1103	0.2475
Loa Loa (eye worm)	ctsf protein	0.0211	0.3004	0.9163
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0488	0.1471
Onchocerca volvulus		0.0211	0.3004	0.9066
Entamoeba histolytica	cysteine protease, putative	0.0111	0.147	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0211	0.3004	0.9163
Entamoeba histolytica	cysteine protease, putative	0.0111	0.147	0.4054
Echinococcus multilocularis	survival motor neuron protein 1	0.0229	0.3278	0.3273
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0059	0.0673	0.151
Schistosoma mansoni	cpg binding protein	0.0031	0.0251	0.0251
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0211	0.3004	1
Leishmania major	hypothetical protein, conserved	0.0024	0.0147	0.0329
Echinococcus granulosus	cpg binding protein	0.0031	0.0251	0.0245
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0211	0.3004	0.8992
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0017	0.0026	0.0019
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0043	0.0425	0.0425
Trypanosoma cruzi	cysteine peptidase, putative	0.0306	0.4458	1
Loa Loa (eye worm)	hypothetical protein	0.0211	0.3004	0.9163
Leishmania major	cathepsin L-like protease	0.0211	0.3004	0.6739
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0035	0.0306	0.0299
Trypanosoma cruzi	cysteine proteinase, putative	0.0111	0.147	0.3299
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0211	0.3004	0.8992
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0043	0.0425	0.1277
Trypanosoma cruzi	cysteine proteinase, putative	0.0111	0.147	0.3299
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0306	0.4458	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0211	0.3004	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0306	0.4458	1
Toxoplasma gondii	aldehyde dehydrogenase	0.0059	0.0673	0.1842
Leishmania major	cysteine peptidase A (CPA)	0.0211	0.3004	0.6739
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0043	0.0425	0.0973
Plasmodium vivax	vivapain-2	0.0211	0.3004	1
Trichomonas vaginalis	CMGC family protein kinase	0.0049	0.0528	0.0361
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0049	0.0528	0.1594
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0111	0.147	0.4633
Schistosoma mansoni	hypothetical protein	0.0033	0.0278	0.0278
Echinococcus granulosus	cathepsin b	0.0186	0.2618	0.2613
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0043	0.0425	0.0425
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0512	0.1544
Brugia malayi	cathepsin B-like cysteine proteinase	0.0186	0.2618	0.7983
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0143	0.1958	0.5966
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0043	0.0425	0.0973
Leishmania major	cathepsin L-like protease	0.0211	0.3004	0.6739
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0059	0.0673	0.0667
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0043	0.0425	0.0425
Echinococcus granulosus	cathepsin b	0.0186	0.2618	0.2613
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0043	0.0425	0.0425
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0043	0.0425	0.1277
Entamoeba histolytica	cysteine proteinase 1, putative	0.0111	0.147	0.4054
Leishmania major	cathepsin L-like protease	0.0306	0.4458	1
Entamoeba histolytica	cysteine proteinase, putative	0.0111	0.147	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0143	0.1958	0.5966
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0211	0.3004	0.8992
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0673	0.5
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0211	0.3004	0.2999
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0043	0.0425	0.0973
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0211	0.3004	0.8992
Leishmania major	cathepsin L-like protease	0.0306	0.4458	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0425	0.1277
Leishmania major	cathepsin L-like protease	0.0211	0.3004	0.6739
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0211	0.3004	0.8992
Echinococcus multilocularis	cathepsin L cysteine protease	0.0211	0.3004	0.2999
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0049	0.0528	0.0522
Plasmodium vivax	vivapain-3	0.0111	0.147	0.4633
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0043	0.0425	0.0973
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0147	0.0427
Schistosoma mansoni	cathepsin F (C01 family)	0.0211	0.3004	0.3004
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0059	0.0682	0.0676
Loa Loa (eye worm)	fibroinase	0.0211	0.3004	0.9163
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.0512	0.1544
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0111	0.147	0.147
Giardia lamblia	Cathepsin B precursor	0.0087	0.1103	1
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0049	0.0528	0.1185
Leishmania major	cathepsin L-like protease	0.0211	0.3004	0.6739
Schistosoma mansoni	microtubule-associated protein tau	0.0668	1	1
Echinococcus multilocularis	cysteine protease	0.0211	0.3004	0.2999
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.0225	0.0273
Echinococcus multilocularis	microtubule associated protein 2	0.0668	1	1
Schistosoma mansoni	cathepsin B (C01 family)	0.0043	0.0425	0.0425
Schistosoma mansoni	cpg binding protein	0.0028	0.0199	0.0199
Echinococcus granulosus	cysteine protease	0.0111	0.147	0.1464
Trypanosoma cruzi	major cysteine proteinase, putative	0.0043	0.0425	0.0953
Brugia malayi	cathepsin L-like precursor	0.0143	0.1958	0.5966
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0111	0.147	0.3299
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0043	0.0425	0.0973
Echinococcus granulosus	cathepsin L	0.0043	0.0425	0.0418
Onchocerca volvulus		0.0047	0.0488	0.0935
Echinococcus granulosus	cathepsin L	0.0111	0.147	0.1464
Entamoeba histolytica	cysteine proteinase, putative	0.0111	0.147	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0143	0.1958	0.5347
Entamoeba histolytica	cysteine protease, putative	0.0111	0.147	0.4054
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0111	0.147	0.147
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0068	0.0819	0.2482
Leishmania major	cathepsin L-like protease	0.0306	0.4458	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0211	0.3004	0.2999
Toxoplasma gondii	cathepsin CPL	0.0211	0.3004	1
Giardia lamblia	Kinase, CMGC MAPK	0.0049	0.0528	0.1528
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0043	0.0425	0.0425
Brugia malayi	hypothetical protein	0.0229	0.3278	1
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0059	0.0673	0.0667
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0199	0.0192
Plasmodium falciparum	serine repeat antigen 4	0.0043	0.0425	0.0973
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0049	0.0528	0.1185
Schistosoma mansoni	hypothetical protein	0.002	0.0079	0.0079
Echinococcus granulosus	survival motor neuron protein 1	0.0229	0.3278	0.3273
Giardia lamblia	Cathepsin B precursor	0.0087	0.1103	1
Brugia malayi	Papain family cysteine protease containing protein	0.0043	0.0425	0.1277
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0043	0.0425	0.1277
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0023	0.0132	0.0125
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0043	0.0425	0.0425
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0046	0.0478	0.0478
Brugia malayi	Cathepsin L-like precursor	0.0211	0.3004	0.9163
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.0512	0.1544
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0211	0.3004	1
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0026	0.0026
Onchocerca volvulus		0.0211	0.3004	0.9066
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0049	0.0528	0.1185
Onchocerca volvulus		0.0143	0.1958	0.5687
Schistosoma mansoni	hypothetical protein	0.0164	0.2284	0.2284
Schistosoma mansoni	cathepsin S (C01 family)	0.0043	0.0425	0.0425
Trichomonas vaginalis	CMGC family protein kinase	0.0049	0.0528	0.0361
Schistosoma mansoni	hypothetical protein	0.0015	0.0007	0.0007
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0059	0.0682	0.0676
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0043	0.0425	0.0973
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0211	0.3004	0.8992
Leishmania major	cathepsin L-like protease	0.0211	0.3004	0.6739
Onchocerca volvulus		0.0211	0.3004	0.9066
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0211	0.3004	0.8992
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0211	0.3004	0.9163
Schistosoma mansoni	cathepsin F (C01 family)	0.0211	0.3004	0.3004
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0211	0.3004	0.8992
Trypanosoma cruzi	cysteine peptidase, putative	0.0068	0.0819	0.1837
Echinococcus granulosus	cathepsin l1	0.0211	0.3004	0.2999
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0425	0.1277
Brugia malayi	Cathepsin L-like precursor	0.0211	0.3004	0.9163
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0819	0.2482
Echinococcus multilocularis	cathepsin L cysteine protease	0.0211	0.3004	0.2999
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0049	0.0528	0.1185
Echinococcus multilocularis	mitogen activated protein kinase	0.0049	0.0528	0.0522
Plasmodium falciparum	serine repeat antigen 5	0.0043	0.0425	0.0973
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0017	0.0026	0.0019
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0199	0.0587
Onchocerca volvulus	Cathepsin F homolog	0.0211	0.3004	0.9066
Echinococcus granulosus	cathepsin L cysteine protease	0.0111	0.147	0.1464
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0111	0.147	0.3299
Plasmodium vivax	vivapain-2	0.0211	0.3004	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0306	0.4458	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0211	0.3004	0.8992
Brugia malayi	Pre-SET motif family protein	0.0202	0.2867	0.8744
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0211	0.3004	0.8992
Plasmodium falciparum	serine repeat antigen 1	0.0043	0.0425	0.0973
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0819	0.2482
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0211	0.3004	0.8992
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0186	0.2618	0.2618
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0087	0.1103	0.1103
Schistosoma mansoni	serine/threonine protein kinase	0.0049	0.0528	0.0528
Brugia malayi	Cathepsin L-like precursor	0.0143	0.1958	0.5966
Entamoeba histolytica	cysteine proteinase, putative	0.0143	0.1958	0.5946
Plasmodium vivax	serine-repeat antigen (SERA)	0.0043	0.0425	0.0973
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0342	0.1024
Loa Loa (eye worm)	hypothetical protein	0.0043	0.043	0.1292
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0211	0.3004	0.8992
Echinococcus granulosus	dnaJ subfamily B	0.0396	0.5835	0.5832
Brugia malayi	hypothetical protein	0.0016	0.0014	0.0023
Echinococcus granulosus	fetal alzheimer antigen falz	0.0023	0.0132	0.0125
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.0225	0.0225
Entamoeba histolytica	cysteine protease, putative	0.0111	0.147	0.4054
Onchocerca volvulus		0.003	0.0225	0.0084
Brugia malayi	PHD-finger family protein	0.0026	0.0167	0.0488
Trypanosoma cruzi	cysteine peptidase, putative	0.0211	0.3004	0.6739
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0186	0.2618	0.2618
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0211	0.3004	0.8992
Plasmodium vivax	unspecified product	0.0068	0.0819	0.2352
Toxoplasma gondii	cathepsin CPC1	0.0043	0.0425	0.0973
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0202	0.2867	0.8744
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0278	0.0829
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0211	0.3004	0.8992
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0111	0.147	0.3299
Plasmodium falciparum	serine repeat antigen 7	0.0043	0.0425	0.0973
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0043	0.0425	0.0973
Brugia malayi	Papain family cysteine protease containing protein	0.0043	0.0425	0.1277
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0211	0.3004	0.8992
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0043	0.0425	0.0425
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0043	0.0425	0.0425
Brugia malayi	cathepsin F-like cysteine proteinase	0.0068	0.0819	0.2482
Echinococcus multilocularis	cathepsin L	0.0043	0.0425	0.0418
Schistosoma mansoni	cathepsin s	0.0068	0.0819	0.0819
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0425	0.1277
Brugia malayi	cathepsin L-like cysteine proteinase	0.0043	0.0425	0.1277
Schistosoma mansoni	bromodomain containing protein	0.0063	0.0735	0.0735
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0046	0.0478	0.0471
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0043	0.0425	0.0973
Brugia malayi	Papain family cysteine protease containing protein	0.0111	0.147	0.4474
Entamoeba histolytica	cysteine proteinase, putative	0.0111	0.147	0.4054
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0035	0.0306	0.0299
Entamoeba histolytica	cysteine protease, putative	0.0111	0.147	0.4054
Echinococcus multilocularis	cathepsin b	0.0186	0.2618	0.2613
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0087	0.1103	0.2475
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0819	0.2482
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0087	0.1103	0.2475
Plasmodium falciparum	serine repeat antigen 2	0.0043	0.0425	0.0973
Entamoeba histolytica	cysteine protease, putative	0.0111	0.147	0.4054
Plasmodium falciparum	serine repeat antigen 8	0.0043	0.0425	0.0973
Echinococcus multilocularis	cathepsin L	0.0111	0.147	0.1464
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0023	0.0132	0.0132
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0306	0.4458	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0186	0.2618	0.5873
Echinococcus multilocularis	cysteine protease	0.0211	0.3004	0.2999
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0049	0.0528	0.1336
Brugia malayi	Cathepsin L-like precursor	0.0143	0.1958	0.5966
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0306	0.4458	1
Onchocerca volvulus	Cathepsin L homolog	0.0211	0.3004	0.9066
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0046	0.0478	0.0478
Onchocerca volvulus		0.023	0.3293	1
Echinococcus granulosus	cathepsin l1	0.0143	0.1958	0.1953
Plasmodium falciparum	serine repeat antigen 3	0.0043	0.0425	0.0973
Brugia malayi	Cathepsin L-like precursor	0.0211	0.3004	0.9163
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0211	0.3004	0.8992
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0186	0.2618	0.2618
Schistosoma mansoni	hypothetical protein	0.0015	0.0007	0.0007
Brugia malayi	hypothetical protein	0.0024	0.0147	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0278	0.0829
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0306	0.4458	1
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0043	0.0425	0.0425
Entamoeba histolytica	cysteine protease, putative	0.0111	0.147	0.4054
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0026	0.0026
Onchocerca volvulus	Cathepsin L homolog	0.0043	0.0425	0.073
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0056	0.0631	0.1694
Plasmodium vivax	unspecified product	0.0111	0.147	0.4633
Entamoeba histolytica	cysteine protease, putative	0.0111	0.147	0.4054
Onchocerca volvulus		0.0211	0.3004	0.9066
Loa Loa (eye worm)	bromodomain containing protein	0.0017	0.0035	0.0086
Schistosoma mansoni	hypothetical protein	0.0015	0.0007	0.0007
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0199	0.0587
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0211	0.3004	0.8992
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0059	0.0673	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0306	0.4458	1
Schistosoma mansoni	zinc finger protein	0.0021	0.0088	0.0088
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0673	0.0673
Schistosoma mansoni	hypothetical protein	0.0164	0.2284	0.2284
Echinococcus granulosus	mitogen activated protein kinase	0.0049	0.0528	0.0522
Trypanosoma cruzi	cruzipain precursor, putative	0.0068	0.0819	0.1837
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.147	0.3646
Plasmodium vivax	serine-repeat antigen (SERA)	0.0043	0.0425	0.0973
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0238	0.3412	0.7654
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0673	0.5
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0425	0.1277
Schistosoma mansoni	hypothetical protein	0.0396	0.5835	0.5835
Trypanosoma cruzi	major cysteine proteinase, putative	0.0138	0.1878	0.4214
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0043	0.0425	0.0973
Echinococcus multilocularis	dnaJ subfamily B	0.0396	0.5835	0.5832
Entamoeba histolytica	cysteine proteinase, putative	0.0211	0.3004	1
Brugia malayi	Cathepsin L-like precursor	0.0211	0.3004	0.9163
Trichomonas vaginalis	set domain proteins, putative	0.023	0.3293	1
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0043	0.0425	0.1277
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0211	0.3004	0.8992
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0043	0.0425	0.0973
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0087	0.1103	0.2365
Echinococcus multilocularis	cathepsin b	0.0186	0.2618	0.2613
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0211	0.3004	0.9163
Trypanosoma cruzi	cruzipain precursor, putative	0.0306	0.4458	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0377	0.1131
Plasmodium falciparum	serine repeat antigen 6	0.0043	0.0425	0.0973
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0211	0.3004	0.2999
Schistosoma mansoni	cpg binding protein	0.0031	0.0251	0.0251
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0211	0.3004	0.8992
Loa Loa (eye worm)	cathepsin B	0.0087	0.1103	0.3351
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0211	0.3004	0.8992
Toxoplasma gondii	cathepsin B	0.0087	0.1103	0.3347
Onchocerca volvulus		0.0211	0.3004	0.9066
Entamoeba histolytica	cysteine protease, putative	0.0111	0.147	0.4054
Brugia malayi	Bromodomain containing protein	0.0037	0.0341	0.1021
Echinococcus granulosus	geminin	0.0164	0.2284	0.2279
Toxoplasma gondii	cathepsin CPC2	0.0043	0.0425	0.0973
Loa Loa (eye worm)	hypothetical protein	0.0186	0.2618	0.7983
Plasmodium vivax	unspecified product	0.0043	0.0425	0.0973
Onchocerca volvulus		0.0211	0.3004	0.9066
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0425	0.1277
Entamoeba histolytica	cysteine proteinase 2	0.0111	0.147	0.4054
Plasmodium vivax	vivapain-1	0.0111	0.147	0.4633
Onchocerca volvulus		0.0043	0.0425	0.073
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0211	0.3004	0.8992
Loa Loa (eye worm)	PHD-finger family protein	0.002	0.0079	0.022
Brugia malayi	fibroinase precursor	0.0043	0.0425	0.1277
Entamoeba histolytica	cysteine protease, putative	0.0111	0.147	0.4054
Schistosoma mansoni	hypothetical protein	0.0015	0.0007	0.0007
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0673	0.0673
Brugia malayi	Papain family cysteine protease containing protein	0.0043	0.0425	0.1277
Loa Loa (eye worm)	hypothetical protein	0.0229	0.3278	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0143	0.1958	0.1958
Brugia malayi	Pre-SET motif family protein	0.003	0.0225	0.0666
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0211	0.3004	0.2999
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0488	0.0488
Echinococcus granulosus	zinc finger protein	0.0021	0.0088	0.0081
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0043	0.0425	0.0973
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.0512	0.1544
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.006	0.0692	0.0692
Loa Loa (eye worm)	hypothetical protein	0.0143	0.1958	0.5966
Entamoeba histolytica	cysteine protease, putative	0.0111	0.147	0.4054
Onchocerca volvulus		0.0211	0.3004	0.9066
Brugia malayi	cathepsin L precursor	0.0043	0.0425	0.1277
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0147	0.0329
Echinococcus multilocularis	geminin	0.0164	0.2284	0.2279
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0049	0.0528	0.1185
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0043	0.0425	0.0973
Brugia malayi	Cathepsin L-like precursor	0.0068	0.0819	0.2482
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0306	0.4458	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0211	0.3004	0.8992
Echinococcus granulosus	histone lysine methyltransferase setb	0.0046	0.0478	0.0471
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0147	0.0329
Entamoeba histolytica	cysteine protease, putative	0.0111	0.147	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0821	0.249
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0068	0.0819	0.2482
Echinococcus multilocularis	cpg binding protein	0.0031	0.0251	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0425	0.1277
Onchocerca volvulus	Cathepsin L homolog	0.0211	0.3004	0.9066
Brugia malayi	Cathepsin L-like precursor	0.0211	0.3004	0.9163
Entamoeba histolytica	cysteine proteinase, putative	0.0211	0.3004	1
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0043	0.0425	0.0973
Trypanosoma cruzi	cysteine protease, putative	0.0111	0.147	0.3299
Echinococcus granulosus	mitogen activated protein kinase 3	0.0049	0.0528	0.0522
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0211	0.3004	0.8992
Echinococcus multilocularis	zinc finger protein	0.0021	0.0088	0.0081

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 1 uM	Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 60 mins	ChEMBL.	23357035
Emax (functional)	= 46.2 %	Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 60 mins relative to OEA	ChEMBL.	23357035

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2336769

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1734730