Detailed information for compound 1744707

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 578.776 | Formula: C30H58O10
  • H donors: 5 H acceptors: 6 LogP: 6.62 Rotable bonds: 26
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCCCCCCCCCCCCCCCCOC[C@H](COC(=O)O[C@H]1[C@@H](O)[C@@H](O)[C@@H]([C@@H]([C@H]1O)CO)O)OC
  • InChi: 1S/C30H58O10/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-38-21-23(37-2)22-39-30(36)40-29-26(33)24(20-31)25(32)27(34)28(29)35/h23-29,31-35H,3-22H2,1-2H3/t23-,24+,25-,26-,27+,28+,29-/m1/s1
  • InChiKey: ARSOCJAZLCXHOY-CEXVJZLNSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens v-akt murine thymoma viral oncogene homolog 1 Starlite/ChEMBL References
Homo sapiens v-akt murine thymoma viral oncogene homolog 2 References
Homo sapiens v-akt murine thymoma viral oncogene homolog 3 References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi p70 ribosomal S6 kinase beta Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus serine threonine protein kinase nrc Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis rac serine:threonine kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis Glutaredoxin protein 5 Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma brucei rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma cruzi Protein kinase B Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum RAC serine/threonine-protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad Get druggable targets OG5_126635 All targets in OG5_126635
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus serine/threonine protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma brucei gambiense rac serine-threonine kinase, putative,protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum ko:K04456 RAC serine/threonine-protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum ko:K07390 monothiol glutaredoxin, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma cruzi rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma cruzi rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Neospora caninum Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1), related Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus calcium:calmodulin dependent protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Candida albicans likely protein kinase similar to S. cerevisiae YPK2 (YMR104C) Get druggable targets OG5_126635 All targets in OG5_126635
Loa Loa (eye worm) AGC/RSK/P70 protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium berghei rac-beta serine/threonine protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma congolense rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium falciparum RAC-beta serine/threonine protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Loa Loa (eye worm) AGC/AKT protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum Sodium/potassium-transporting ATPase subunit beta-1, putative Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium knowlesi RAC-beta serine/threonine protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium vivax rac-beta serine/threonine protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum ko:K08792 serum/glucocorticoid regulated kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium yoelii kinase Akt/PKB-related Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma mansoni serine/threonine-protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica protein kinase 2, putative Get druggable targets OG5_126635 All targets in OG5_126635
Giardia lamblia Kinase, AGC PKA Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma mansoni serine/threonine-protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Candida albicans protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus sodium:potassium dependent atpase beta subunit Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus Glutaredoxin protein 5 Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Toxoplasma gondii AGC kinase Get druggable targets OG5_126635 All targets in OG5_126635
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0002 0.0021
Schistosoma mansoni tyrosine kinase 0.0079 0.0055 0.0099
Brugia malayi hypothetical protein 0.0344 0.041 0.0561
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0045 0.001 0.0013
Loa Loa (eye worm) hypothetical protein 0.0988 0.1272 0.1739
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0018 0.0017
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0406 0.0493 0.0674
Echinococcus multilocularis enteropeptidase 0.0216 0.0239 0.0238
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0126 0.0118 0.016
Entamoeba histolytica hypothetical protein 0.0215 0.0237 0.9374
Echinococcus granulosus rhodopsin orphan GPCR 0.0344 0.041 0.041
Echinococcus granulosus jumonji domain containing protein 0.004 0.0003 0.0003
Trichomonas vaginalis hypothetical protein 0.0175 0.0184 0.7677
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0016 0.0021
Schistosoma mansoni acetylcholine receptor subunit beta 0.0191 0.0206 0.0373
Toxoplasma gondii PAN domain-containing protein 0.0212 0.0234 0.0798
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0279 0.0323 0.0322
Brugia malayi Variant SH3 domain containing protein 0.0052 0.0019 0.0026
Echinococcus granulosus tyrosine protein kinase ABL1 0.0049 0.0016 0.0015
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0344 0.041 0.0744
Brugia malayi G protein-coupled receptor F59B2.13 0.0344 0.041 0.0561
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0344 0.041 0.0744
Echinococcus granulosus protein kinase c iota type 0.0043 0.0007 0.0007
Brugia malayi DNA polymerase alpha catalytic subunit 0.0043 0.0007 0.0009
Brugia malayi Tachykinin-like peptides receptor 99D 0.0344 0.041 0.0561
Schistosoma mansoni amine GPCR 0.0344 0.041 0.0744
Echinococcus granulosus kelch ECH associated protein 1 like 0.0097 0.008 0.0079
Echinococcus multilocularis neuropeptides capa receptor 0.0344 0.041 0.041
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0344 0.041 0.041
Loa Loa (eye worm) hypothetical protein 0.0043 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0175 0.0184 0.0252
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0344 0.041 0.0744
Brugia malayi hypothetical protein 0.0344 0.041 0.0561
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0988 0.1272 0.231
Toxoplasma gondii aspartyl protease ASP3 0.0139 0.0135 0.0462
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0215 0.0237 0.0324
Schistosoma mansoni glutamate receptor NMDA 0.0066 0.0038 0.0068
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0038 0.0001 0.0001
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0344 0.041 0.041
Echinococcus multilocularis tyrosine protein kinase HCK 0.0227 0.0253 0.0253
Loa Loa (eye worm) hypothetical protein 0.0406 0.0493 0.0674
Schistosoma mansoni cercarial elastase (S01 family) 0.0216 0.0239 0.0432
Onchocerca volvulus 0.0406 0.0493 0.3038
Loa Loa (eye worm) TK protein kinase 0.0253 0.0288 0.0394
Onchocerca volvulus 0.0212 0.0234 0.1433
Onchocerca volvulus 0.0216 0.0239 0.1462
Entamoeba histolytica protein kinase, putative 0.0043 0.0007 0.029
Brugia malayi Hr1 repeat family protein 0.0043 0.0007 0.0009
Schistosoma mansoni tyrosine kinase 0.0279 0.0323 0.0585
Onchocerca volvulus 0.0215 0.0237 0.1454
Echinococcus granulosus glycine receptor subunit beta 0.0406 0.0493 0.0493
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0049 0.0016 0.0015
Loa Loa (eye worm) PAN domain-containing protein 0.0212 0.0234 0.0319
Echinococcus granulosus protein kinase c epsilon type 0.0043 0.0007 0.0007
Onchocerca volvulus 0.0212 0.0234 0.1433
Loa Loa (eye worm) hypothetical protein 0.0344 0.041 0.0561
Schistosoma mansoni jumonji domain containing protein 0.0075 0.005 0.009
Schistosoma mansoni tyrosine kinase 0.0089 0.0069 0.0124
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0215 0.0237 0.0324
Echinococcus granulosus Protein kinase C brain isozyme 0.0043 0.0007 0.0007
Echinococcus multilocularis sodium channel protein 0.0063 0.0034 0.0033
Brugia malayi hypothetical protein 0.0139 0.0135 0.0185
Onchocerca volvulus 0.0344 0.041 0.2525
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0007 0.0012
Onchocerca volvulus 0.1247 0.1619 1
Onchocerca volvulus 0.0181 0.0193 0.1177
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0406 0.0493 0.0674
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0002 0.0096
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.001 0.0018
Schistosoma mansoni amine GPCR 0.0344 0.041 0.0744
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0042 0.0006 0.0254
Plasmodium falciparum plasmepsin X 0.0139 0.0135 0.2091
Loa Loa (eye worm) hypothetical protein 0.0344 0.041 0.0561
Echinococcus granulosus growth factor receptor bound protein 2 0.0068 0.0041 0.004
Onchocerca volvulus Putative nachr subunit 0.0406 0.0493 0.3038
Loa Loa (eye worm) hypothetical protein 0.0215 0.0237 0.0324
Trichomonas vaginalis AGC family protein kinase 0.013 0.0124 0.5177
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0406 0.0493 0.0674
Brugia malayi putative neuropeptide receptor 0.0344 0.041 0.0561
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0406 0.0493 0.0674
Trichomonas vaginalis AGC family protein kinase 0.013 0.0124 0.5177
Onchocerca volvulus 0.0344 0.041 0.2525
Schistosoma mansoni integrin alpha-4 0.077 0.0981 0.178
Brugia malayi Guanylyl cyclase protein 23 0.0104 0.0089 0.0121
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0045 0.001 0.001
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0045 0.001 0.0013
Schistosoma mansoni biogenic amine receptor 0.0344 0.041 0.0744
Schistosoma mansoni neuropeptide receptor 0.0344 0.041 0.0744
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0007 0.0012
Loa Loa (eye worm) hypothetical protein 0.0648 0.0817 0.1117
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0036 0.0317
Loa Loa (eye worm) hypothetical protein 0.0212 0.0234 0.0319
Loa Loa (eye worm) hypothetical protein 0.0344 0.041 0.0561
Loa Loa (eye worm) integrin beta-2 0.5503 0.7313 1
Echinococcus granulosus DNA polymerase subunit gamma 0.0095 0.0077 0.0077
Echinococcus multilocularis serotonin receptor 0.0344 0.041 0.041
Echinococcus granulosus nmda type glutamate receptor 0.0066 0.0038 0.0038
Echinococcus granulosus tyrosine protein kinase HCK 0.0227 0.0253 0.0253
Onchocerca volvulus 0.0988 0.1272 0.7857
Schistosoma mansoni neuropeptide receptor 0.1174 0.152 0.276
Schistosoma mansoni neurotransmitter gated ion channel 0.0191 0.0206 0.0373
Brugia malayi hypothetical protein 0.0216 0.0239 0.0326
Loa Loa (eye worm) hypothetical protein 0.0406 0.0493 0.0674
Echinococcus granulosus tyrosine protein kinase Srms 0.0049 0.0016 0.0015
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0671 0.0848 0.0848
Loa Loa (eye worm) hypothetical protein 0.0175 0.0184 0.0252
Plasmodium falciparum plasmepsin III 0.0139 0.0135 0.2091
Loa Loa (eye worm) hypothetical protein 0.0648 0.0817 0.1117
Loa Loa (eye worm) PAN domain-containing protein 0.0212 0.0234 0.0319
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0039 0.0002 0.0002
Brugia malayi hypothetical protein 0.0344 0.041 0.0561
Loa Loa (eye worm) hypothetical protein 0.0406 0.0493 0.0674
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0279 0.0323 0.0322
Loa Loa (eye worm) hypothetical protein 0.0192 0.0207 0.0282
Brugia malayi neuropeptide F receptor 0.0344 0.041 0.0561
Brugia malayi PAN domain containing protein 0.0212 0.0234 0.0319
Echinococcus multilocularis tyrosine kinase 0.0049 0.0016 0.0015
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0406 0.0493 0.0493
Brugia malayi Trypsin family protein 0.1247 0.1619 0.2213
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0406 0.0493 0.0674
Loa Loa (eye worm) hypothetical protein 0.0215 0.0237 0.0324
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0344 0.041 0.0561
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0066 0.0038 0.0038
Giardia lamblia Neurogenic locus Notch protein precursor 0.0175 0.0184 1
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0006 0.0051
Schistosoma mansoni growth hormone secretagogue receptor 0.0344 0.041 0.0744
Loa Loa (eye worm) hypothetical protein 0.0406 0.0493 0.0674
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0002 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0344 0.041 0.041
Loa Loa (eye worm) hypothetical protein 0.0344 0.041 0.0561
Schistosoma mansoni neurotransmitter gated ion channel 0.0191 0.0206 0.0373
Loa Loa (eye worm) hypothetical protein 0.1684 0.2203 0.3012
Onchocerca volvulus 0.0344 0.041 0.2525
Echinococcus granulosus tyrosine kinase 0.0089 0.0069 0.0068
Brugia malayi PAN domain containing protein 0.0212 0.0234 0.0319
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0344 0.041 0.0561
Toxoplasma gondii PAN domain-containing protein 0.2229 0.2933 1
Echinococcus multilocularis intersectin 2 0.0042 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0344 0.041 0.0561
Loa Loa (eye worm) hypothetical protein 0.0406 0.0493 0.0674
Echinococcus granulosus c src tyrosine kinase 0.0075 0.005 0.005
Toxoplasma gondii kringle domain-containing protein 0.0348 0.0416 0.1417
Echinococcus granulosus rhodopsin orphan GPCR 0.0344 0.041 0.041
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0066 0.0038 0.0051
Loa Loa (eye worm) hypothetical protein 0.0344 0.041 0.0561
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0002 0.0003
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0348 0.0416 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0246 0.0279 0.0279
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0016 0.0021
Schistosoma mansoni hypothetical protein 0.0181 0.0193 0.0349
Onchocerca volvulus 0.0049 0.0016 0.0084
Onchocerca volvulus 0.0344 0.041 0.2525
Echinococcus granulosus Glutaredoxin protein 5 0.0083 0.006 0.006
Schistosoma mansoni dynamin-associated protein 0.0042 0.0006 0.001
Schistosoma mansoni cercarial elastase (S01 family) 0.0216 0.0239 0.0432
Echinococcus granulosus integrin alpha ps 0.0401 0.0486 0.0486
Echinococcus multilocularis voltage gated potassium channel 0.0045 0.001 0.001
Onchocerca volvulus 0.0042 0.0006 0.0021
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0344 0.041 0.0561
Echinococcus granulosus muscleblind protein 0.0163 0.0168 0.0167
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0002 0.0002
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0036 0.0317
Echinococcus granulosus rhodopsin orphan GPCR 0.0344 0.041 0.041
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0216 0.0239 0.0238
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0352 0.0421 0.0575
Echinococcus granulosus activated cdc42 kinase 1 0.1707 0.2234 0.2233
Loa Loa (eye worm) hypothetical protein 0.0175 0.0184 0.0252
Loa Loa (eye worm) hypothetical protein 0.0344 0.041 0.0561
Echinococcus multilocularis neuropeptide FF receptor 2 0.0344 0.041 0.041
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0253 0.0288 0.0288
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0007 0.0012
Loa Loa (eye worm) melatonin receptor type 1A 0.0344 0.041 0.0561
Trypanosoma brucei RNA helicase, putative 0.0356 0.0427 0.3787
Echinococcus granulosus protein kinase C gamma type 0.0043 0.0007 0.0007
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.001 0.0018
Schistosoma mansoni tyrosine kinase 0.0102 0.0086 0.0155
Loa Loa (eye worm) hypothetical protein 0.0525 0.0653 0.0892
Echinococcus multilocularis neuropeptide s receptor 0.0344 0.041 0.041
Echinococcus granulosus g-protein coupled receptor 0.0344 0.041 0.041
Schistosoma mansoni hypothetical protein 0.0192 0.0207 0.0375
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0406 0.0493 0.0493
Echinococcus granulosus fmrfamide receptor 0.0344 0.041 0.041
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0279 0.0323 0.0322
Loa Loa (eye worm) hypothetical protein 0.048 0.0593 0.081
Echinococcus granulosus shaker cognate 0.0045 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0066 0.0038 0.0051
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0151 0.0152 0.1344
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0406 0.0493 0.0674
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0075 0.005 0.005
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0007 0.0305
Loa Loa (eye worm) hypothetical protein 0.0072 0.0046 0.0063
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0344 0.041 0.041
Schistosoma mansoni nAChR subunit 0.0406 0.0493 0.0895
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0121 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0049 0.0016 0.0021
Echinococcus multilocularis g protein coupled receptor 0.0344 0.041 0.041
Schistosoma mansoni hypothetical protein 0.0098 0.008 0.0145
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0406 0.0493 0.0493
Echinococcus multilocularis tyrosine protein kinase Srms 0.0253 0.0288 0.0288
Brugia malayi Dopamine receptor protein 1 0.0344 0.041 0.0561
Onchocerca volvulus 0.0344 0.041 0.2525
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0049 0.0016 0.0627
Echinococcus granulosus g protein coupled receptor 0.0344 0.041 0.041
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0083 0.0061 0.143
Loa Loa (eye worm) hypothetical protein 0.0215 0.0237 0.0324
Onchocerca volvulus 0.0212 0.0234 0.1433
Loa Loa (eye worm) voltage-dependent calcium channel 0.0041 0.0005 0.0006
Loa Loa (eye worm) RGC/RGC protein kinase 0.0209 0.0229 0.0313
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0139 0.0135 0.0462
Echinococcus multilocularis rhodopsin orphan GPCR 0.0344 0.041 0.041
Giardia lamblia Tenascin-37 0.0175 0.0184 1
Loa Loa (eye worm) hypothetical protein 0.0344 0.041 0.0561
Loa Loa (eye worm) hypothetical protein 0.0066 0.0038 0.0051
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0525 0.0653 0.0892
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0052 0.0019 0.0026
Echinococcus multilocularis sex peptide receptor 0.0344 0.041 0.041
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0191 0.0206 0.0281
Schistosoma mansoni nAChR subunit 0.0191 0.0206 0.0373
Loa Loa (eye worm) GABA receptor subunit 0.0215 0.0237 0.0324
Loa Loa (eye worm) hypothetical protein 0.0139 0.0135 0.0185
Schistosoma mansoni hypothetical protein 0.0216 0.0239 0.0432
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0279 0.0323 0.0322
Loa Loa (eye worm) hypothetical protein 0.0195 0.0211 0.0288
Loa Loa (eye worm) hypothetical protein 0.0344 0.041 0.0561
Mycobacterium ulcerans adenylylate/guanylate cyclase 0.012 0.011 0.1895
Echinococcus multilocularis G-protein coupled receptor, putative 0.0344 0.041 0.041
Echinococcus multilocularis Glutaredoxin protein 5 0.0083 0.006 0.006
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0017 0.0154
Echinococcus multilocularis rhodopsin orphan GPCR 0.0344 0.041 0.041
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0911 0.1168 0.1597
Echinococcus multilocularis glycoprotein Antigen 5 0.0216 0.0239 0.0238
Schistosoma mansoni tyrosine kinase 0.0079 0.0055 0.0099
Echinococcus multilocularis serine:threonine protein kinase N2 0.0043 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0344 0.041 0.0561
Leishmania major cathepsin L-like protease 0.0064 0.0036 0.0317
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0406 0.0493 0.0895
Loa Loa (eye worm) TK/ABL protein kinase 0.0049 0.0016 0.0021
Echinococcus granulosus peptide allatostatin:somatostatin 0.0344 0.041 0.041
Brugia malayi GnHR receptor homolog 0.0344 0.041 0.0561
Loa Loa (eye worm) hypothetical protein 0.0191 0.0206 0.0281
Schistosoma mansoni voltage-gated cation channel 0.0121 0.0112 0.0203
Echinococcus granulosus potassium voltage gated channel protein 0.0045 0.001 0.001
Schistosoma mansoni neuropeptide f receptor 76f 0.0344 0.041 0.0744
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0066 0.0038 0.0038
Plasmodium falciparum plasmepsin II 0.0217 0.024 0.5048
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0038 0.0001 0.0001
Onchocerca volvulus 0.0191 0.0206 0.1259
Brugia malayi Variant SH3 domain containing protein 0.0042 0.0006 0.0007
Echinococcus multilocularis tyrosine protein kinase shark 0.0049 0.0016 0.0015
Loa Loa (eye worm) DOMON domain-containing protein 0.0181 0.0193 0.0263
Echinococcus multilocularis rhodopsin orphan GPCR 0.0344 0.041 0.041
Echinococcus granulosus kelch ECH associated protein 1 0.0097 0.008 0.0079
Schistosoma mansoni nAChR subunit 0.0406 0.0493 0.0895
Schistosoma mansoni vesicular amine transporter 0.0045 0.001 0.0018
Entamoeba histolytica protein kinase, putative 0.0126 0.0118 0.4649
Schistosoma mansoni histamine h1 receptor 0.0344 0.041 0.0744
Loa Loa (eye worm) hypothetical protein 0.0039 0.0002 0.0003
Echinococcus multilocularis protein jagged 2 0.0175 0.0184 0.0184
Schistosoma mansoni tyrosine kinase 0.007 0.0043 0.0077
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0406 0.0493 0.0674
Schistosoma mansoni amine GPCR 0.0344 0.041 0.0744
Schistosoma mansoni nAChR subunit 0.0406 0.0493 0.0895
Schistosoma mansoni tyrosine kinase 0.0075 0.005 0.009
Brugia malayi Dopamine receptor 0.0344 0.041 0.0561
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.088 0.1127 1
Echinococcus multilocularis muscleblind protein 1 0.0163 0.0168 0.0167
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0344 0.041 0.041
Entamoeba histolytica protein kinase 2, putative 0.0083 0.0061 0.2425
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0406 0.0493 0.0493
Loa Loa (eye worm) hypothetical protein 0.0191 0.0206 0.0281
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0066 0.0038 0.0038
Toxoplasma gondii ABC1 family protein 0.0039 0.0002 0.0008
Echinococcus granulosus biogenic amine 5HT receptor 0.0344 0.041 0.041
Entamoeba histolytica hypothetical protein 0.0066 0.0038 0.1502
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0191 0.0206 0.0205
Loa Loa (eye worm) hypothetical protein 0.0039 0.0002 0.0003
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0217 0.024 0.024
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0344 0.041 0.0561
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0406 0.0493 0.0674
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.0036 0.0317
Schistosoma mansoni growth factor receptor-bound protein 0.0068 0.0041 0.0073
Loa Loa (eye worm) hypothetical protein 0.0215 0.0237 0.0324
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0344 0.041 0.041
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0043 0.0007 0.0007
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0216 0.0239 0.0432
Onchocerca volvulus 0.0195 0.0211 0.1289
Schistosoma mansoni serine/threonine kinase 0.0043 0.0007 0.0012
Loa Loa (eye worm) TYRA-2 protein 0.0344 0.041 0.0561
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0083 0.006 0.006
Brugia malayi hypothetical protein 0.0344 0.041 0.0561
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0279 0.0323 0.0322
Loa Loa (eye worm) hypothetical protein 0.0352 0.0421 0.0575
Brugia malayi EGF-like domain containing protein 0.0175 0.0184 0.0252
Loa Loa (eye worm) hypothetical protein 0.0344 0.041 0.0561
Brugia malayi PAN domain containing protein 0.0212 0.0234 0.0319
Loa Loa (eye worm) beta-lactamase 0.0039 0.0002 0.0003
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0216 0.0239 0.0238
Loa Loa (eye worm) hypothetical protein 0.0344 0.041 0.0561
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0018 0.0032
Brugia malayi Calcitonin receptor-like protein seb-1 0.0105 0.0091 0.0124
Echinococcus multilocularis adam 0.0175 0.0184 0.0184
Brugia malayi protein kinase C II. 0.0043 0.0007 0.0009
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0171 0.0178 0.0178
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0043 0.0007 0.0007
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0066 0.0038 0.0038
Trichomonas vaginalis AGC family protein kinase 0.013 0.0124 0.5177
Echinococcus granulosus voltage dependent calcium channel 0.0041 0.0005 0.0004
Loa Loa (eye worm) voltage-gated potassium channel 0.0045 0.001 0.0013
Loa Loa (eye worm) hypothetical protein 0.0217 0.024 0.0328
Echinococcus granulosus dro:myosuppressin receptor 0.0344 0.041 0.041
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0344 0.041 0.0561
Loa Loa (eye worm) hypothetical protein 0.0215 0.0237 0.0324
Echinococcus granulosus tyrosine protein kinase shark 0.0049 0.0016 0.0015
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0043 0.0007 0.0007
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0015 0.0026
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0344 0.041 0.0744
Echinococcus granulosus tm gpcr rhodopsin 0.0344 0.041 0.041
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0344 0.041 0.0744
Echinococcus granulosus 7TM GPCR rhodopsin 0.0344 0.041 0.041
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0209 0.0229 0.1403
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0279 0.0323 0.0322
Loa Loa (eye worm) hypothetical protein 0.0344 0.041 0.0561
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.0076 0.0075
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0344 0.041 0.0744
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0066 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0344 0.041 0.0561
Echinococcus multilocularis neuropeptide receptor A26 0.0344 0.041 0.041
Schistosoma mansoni cathepsin D (A01 family) 0.0417 0.0508 0.0921
Loa Loa (eye worm) glutamate receptor 0.0066 0.0038 0.0051
Brugia malayi aspartic protease BmAsp-2, identical 0.0139 0.0135 0.0185
Echinococcus granulosus expressed protein 0.0038 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0163 0.0168 0.0229
Loa Loa (eye worm) hypothetical protein 0.0344 0.041 0.0561
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0043 0.0007 0.0009
Brugia malayi Protein kinase domain containing protein 0.0049 0.0016 0.0021
Brugia malayi G-protein coupled receptor 0.0344 0.041 0.0561
Brugia malayi Serotonin receptor 0.0344 0.041 0.0561
Echinococcus multilocularis potassium voltage gated channel protein 0.0045 0.001 0.001
Giardia lamblia Kinase, AGC PKA 0.0083 0.0061 0.2964
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0139 0.0135 0.0245
Loa Loa (eye worm) hypothetical protein 0.0212 0.0234 0.0319
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0215 0.0237 0.0324
Echinococcus multilocularis integrin beta 2 0.4289 0.5688 0.5688
Brugia malayi hypothetical protein 0.0066 0.0038 0.0051
Echinococcus granulosus tyrosine kinase 0.0049 0.0016 0.0015
Echinococcus multilocularis growth factor receptor bound protein 2 0.0052 0.0019 0.0019
Echinococcus granulosus tachykinin peptides receptor 99D 0.0344 0.041 0.041
Loa Loa (eye worm) hypothetical protein 0.0066 0.0038 0.0051
Schistosoma mansoni voltage-gated potassium channel 0.0525 0.0653 0.1185
Loa Loa (eye worm) ACC-1 protein 0.0406 0.0493 0.0674
Echinococcus multilocularis DNA polymerase alpha catalytic subunit 0.0053 0.002 0.002
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0102 0.0086 0.0085
Echinococcus granulosus serine:threonine protein kinase N2 0.0043 0.0007 0.0007
Echinococcus granulosus tyrosine kinase 0.0253 0.0288 0.0288
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0217 0.024 1
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0043 0.0007 0.0007
Loa Loa (eye worm) TK/INSR protein kinase 0.007 0.0043 0.0058
Echinococcus granulosus metabotropic glutamate receptor 5 0.0066 0.0038 0.0038
Echinococcus multilocularis neuropeptide Y receptor 0.0344 0.041 0.041
Loa Loa (eye worm) hypothetical protein 0.1247 0.1619 0.2213
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0406 0.0493 0.0493
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0007 0.0305
Schistosoma mansoni hypothetical protein 0.0344 0.041 0.0744
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0075 0.005 0.009
Plasmodium vivax plasmepsin IV, putative 0.0217 0.024 0.5756
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0002 0.0096
Brugia malayi sulfakinin receptor protein 0.0344 0.041 0.0561
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0406 0.0493 0.0493
Echinococcus multilocularis rhodopsin orphan GPCR 0.0344 0.041 0.041
Echinococcus multilocularis glycine receptor subunit beta 0.0406 0.0493 0.0493
Schistosoma mansoni hypothetical protein 0.0344 0.041 0.0744
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0049 0.0016 0.0015
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0191 0.0206 0.0281
Entamoeba histolytica protein kinase, putative 0.013 0.0124 0.4911
Echinococcus multilocularis protein kinase c iota type 0.0043 0.0007 0.0007
Schistosoma mansoni biogenic amine receptor 0.0344 0.041 0.0744
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0036 0.0317
Echinococcus granulosus g protein coupled receptor 0.0344 0.041 0.041
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0344 0.041 0.041
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0066 0.0038 0.0038
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0139 0.0135 0.0245
Echinococcus granulosus neuropeptide receptor 0.0344 0.041 0.041
Brugia malayi hypothetical protein 0.0049 0.0016 0.0021
Brugia malayi hypothetical protein 0.0344 0.041 0.0561
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.7511 1 1
Echinococcus granulosus neuropeptides capa receptor 0.0344 0.041 0.041
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0216 0.0239 0.0238
Onchocerca volvulus 0.0181 0.0193 0.1177
Onchocerca volvulus Neuropeptide F receptor homolog 0.0344 0.041 0.2525
Leishmania major cathepsin L-like protease 0.0064 0.0036 0.0317
Loa Loa (eye worm) hypothetical protein 0.0191 0.0206 0.0281
Echinococcus multilocularis transfer RNA-Thr 0.1707 0.2234 0.2233
Brugia malayi Trypsin family protein 0.0216 0.0239 0.0326
Schistosoma mansoni serine/threonine-protein kinase 0.0088 0.0068 0.0123
Echinococcus granulosus g protein coupled receptor 0.0344 0.041 0.041
Echinococcus granulosus tyrosine protein kinase Lyn 0.028 0.0324 0.0323
Echinococcus granulosus nervana 2 0.0083 0.006 0.006
Echinococcus granulosus enteropeptidase 0.0216 0.0239 0.0238
Schistosoma mansoni adenoreceptor 0.0344 0.041 0.0744
Echinococcus granulosus insulin growth factor 1 receptor beta 0.007 0.0043 0.0042
Loa Loa (eye worm) hypothetical protein 0.0039 0.0002 0.0003
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0002 0.0096
Schistosoma mansoni serine/threonine-protein kinase 0.0088 0.0068 0.0123
Echinococcus granulosus NDR protein kinase 0.0043 0.0007 0.0007
Echinococcus multilocularis tissue type plasminogen activator 0.0348 0.0416 0.0415
Loa Loa (eye worm) hypothetical protein 0.1247 0.1619 0.2213
Toxoplasma gondii hypothetical protein 0.0212 0.0234 0.0798
Brugia malayi PAN domain containing protein 0.0212 0.0234 0.0319
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0036 0.0317
Echinococcus granulosus glycine receptor subunit alpha 1 0.0406 0.0493 0.0493
Onchocerca volvulus 0.0344 0.041 0.2525
Loa Loa (eye worm) hypothetical protein 0.0191 0.0206 0.0281
Echinococcus multilocularis G protein coupled receptor 139 0.1174 0.152 0.152
Echinococcus granulosus transmembrane protease serine 3 0.0216 0.0239 0.0238
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0002 0.0002
Echinococcus multilocularis tyrosine protein kinase Abl 0.0075 0.005 0.005
Echinococcus multilocularis c src tyrosine kinase 0.0075 0.005 0.005
Brugia malayi hypothetical protein 0.0344 0.041 0.0561
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.001 0.0018
Schistosoma mansoni biogenic amine (5HT) receptor 0.0344 0.041 0.0744
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0344 0.041 0.0744
Trypanosoma brucei rac serine-threonine kinase, putative 0.013 0.0124 0.1104
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0279 0.0323 0.0322
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0279 0.0323 0.0322
Echinococcus granulosus tyrosine protein kinase Blk 0.0253 0.0288 0.0288
Brugia malayi excitatory GABA receptor EXP-1A 0.0406 0.0493 0.0674
Loa Loa (eye worm) AGC/AKT protein kinase 0.013 0.0124 0.0169
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.0046 0.0063
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0121 0.0112 0.0112
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0344 0.041 0.0744
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0029 0.0039
Echinococcus multilocularis NCK adaptor protein 0.0068 0.0041 0.004
Echinococcus multilocularis expressed protein 0.0038 0.0001 0.0001
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0215 0.0237 0.043
Onchocerca volvulus 0.0988 0.1272 0.7857
Onchocerca volvulus 0.0181 0.0193 0.1177
Giardia lamblia hypothetical protein 0.0175 0.0184 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0251 0.0285 0.4988
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0124 0.0115 0.1023
Schistosoma mansoni nAChR subunit 0.0406 0.0493 0.0895
Loa Loa (eye worm) hypothetical protein 0.0406 0.0493 0.0674
Brugia malayi Protein kinase domain containing protein 0.1707 0.2234 0.3054
Schistosoma mansoni metabotropic glutamate receptor 0.0066 0.0038 0.0068
Loa Loa (eye worm) hypothetical protein 0.0212 0.0234 0.0319
Trichomonas vaginalis esterase, putative 0.0039 0.0002 0.0096
Echinococcus granulosus NCK adaptor protein 0.0052 0.0019 0.0019
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0344 0.041 0.041
Onchocerca volvulus 0.0212 0.0234 0.1433
Loa Loa (eye worm) hypothetical protein 0.0039 0.0002 0.0003
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0121 0.0112 0.0112
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0018 0.0023
Echinococcus multilocularis fibrillin 1 0.0175 0.0184 0.0184
Echinococcus granulosus tyrosine protein kinase Fyn 0.0279 0.0323 0.0322
Brugia malayi Protein kinase domain containing protein 0.007 0.0043 0.0058
Loa Loa (eye worm) hypothetical protein 0.0406 0.0493 0.0674
Trichomonas vaginalis AGC family protein kinase 0.013 0.0124 0.5177
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0245 0.0277 0.0502
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0139 0.0135 0.0245
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0216 0.0239 0.0432
Plasmodium falciparum plasmepsin IX 0.0139 0.0135 0.2091
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0191 0.0206 0.0281
Echinococcus granulosus tm gpcr rhodopsin 0.0344 0.041 0.041
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0121 0.0112 0.0112
Schistosoma mansoni integrin beta subunit 0.3407 0.4508 0.8186
Loa Loa (eye worm) G-protein coupled receptor 0.0344 0.041 0.0561
Loa Loa (eye worm) hypothetical protein 0.0344 0.041 0.0561
Echinococcus multilocularis g-protein coupled receptor 0.0344 0.041 0.041
Echinococcus multilocularis nmda type glutamate receptor 0.0066 0.0038 0.0038
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0003 0.0003
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0191 0.0206 0.0281
Loa Loa (eye worm) hypothetical protein 0.0344 0.041 0.0561
Brugia malayi follicle stimulating hormone receptor 0.0344 0.041 0.0561
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0191 0.0206 0.0281
Echinococcus multilocularis nAChR subunit 0.0215 0.0237 0.0237
Plasmodium falciparum plasmepsin VIII, putative 0.0139 0.0135 0.2091
Echinococcus multilocularis muscleblind protein 0.0163 0.0168 0.0167
Onchocerca volvulus 0.019 0.0204 0.1246
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0066 0.0038 0.0051
Loa Loa (eye worm) hypothetical protein 0.0042 0.0006 0.0007
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0036 0.0317
Brugia malayi Sex muscle abnormal protein 5 0.0052 0.0019 0.0026
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0406 0.0493 0.0895
Echinococcus multilocularis neuropeptide receptor 0.1174 0.152 0.152
Echinococcus granulosus voltage dependent calcium channel 0.0121 0.0112 0.0112
Echinococcus multilocularis allatostatin A receptor 0.0344 0.041 0.041
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0406 0.0493 0.0493
Loa Loa (eye worm) hypothetical protein 0.0062 0.0032 0.0044
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0002 0.0021
Echinococcus granulosus metabotropic glutamate receptor 2 0.0066 0.0038 0.0038
Echinococcus multilocularis serine threonine protein kinase 0.0043 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0216 0.0239 0.0326
Brugia malayi solute carrier family 40, member 1 0.0195 0.0211 0.0288
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0344 0.041 0.0744
Loa Loa (eye worm) hypothetical protein 0.0344 0.041 0.0561
Echinococcus granulosus atrial natriuretic peptide receptor 0.0171 0.0178 0.0178
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0216 0.0239 0.0432
Echinococcus multilocularis 0.0046 0.0011 0.0011
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0406 0.0493 0.0493
Echinococcus granulosus nervana 2 0.0083 0.006 0.006
Schistosoma mansoni hypothetical protein 0.0356 0.0427 0.0774
Echinococcus multilocularis epidermal growth factor receptor 0.017 0.0177 0.0177
Echinococcus multilocularis g protein coupled receptor 0.0344 0.041 0.041
Loa Loa (eye worm) hypothetical protein 0.0181 0.0193 0.0263
Loa Loa (eye worm) hypothetical protein 0.0344 0.041 0.0561
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0416 0.0507 0.4498
Loa Loa (eye worm) hypothetical protein 0.0163 0.0168 0.0229
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0036 0.0317
Echinococcus granulosus allatostatin A receptor 0.0344 0.041 0.041
Toxoplasma gondii transporter, cation channel family protein 0.0041 0.0005 0.0016
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0344 0.041 0.0561
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0344 0.041 0.0744
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0344 0.041 0.0744
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0406 0.0493 0.0674
Toxoplasma gondii microneme protein MIC4 0.0212 0.0234 0.0798
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.0028 0.0251
Echinococcus granulosus integrin beta 2 0.4289 0.5688 0.5688
Toxoplasma gondii microneme protein MIC17B 0.0212 0.0234 0.0798
Loa Loa (eye worm) neuropeptide F receptor 0.0344 0.041 0.0561
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0406 0.0493 0.0674
Brugia malayi DNA polymerase I family protein 0.0095 0.0077 0.0105
Echinococcus multilocularis kelch ECH associated protein 1 0.0097 0.008 0.0079
Echinococcus multilocularis protein KINase family member (kin 25) 0.0671 0.0848 0.0848
Schistosoma mansoni hypothetical protein 0.0348 0.0416 0.0754
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0036 0.0317
Echinococcus granulosus rhodopsin orphan GPCR 0.0344 0.041 0.041
Giardia lamblia Tenascin-like 0.0175 0.0184 1
Brugia malayi AKH receptor 0.0344 0.041 0.0561
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0406 0.0493 0.0674
Echinococcus granulosus neuropeptides capa receptor 0.0344 0.041 0.041
Schistosoma mansoni neuropeptide F-like receptor 0.0344 0.041 0.0744
Toxoplasma gondii hypothetical protein 0.0175 0.0184 0.0629
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0045 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0344 0.041 0.0561
Echinococcus multilocularis neuropeptides capa receptor 0.0344 0.041 0.041
Loa Loa (eye worm) hypothetical protein 0.0216 0.0239 0.0326
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0525 0.0653 0.0652
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0215 0.0237 0.0324
Echinococcus multilocularis orexin receptor type 2 0.0344 0.041 0.041
Brugia malayi hypothetical protein 0.0882 0.113 0.1545
Brugia malayi Kringle domain containing protein 0.0348 0.0416 0.0568
Schistosoma mansoni neurotransmitter gated ion channel 0.0215 0.0237 0.043
Loa Loa (eye worm) hypothetical protein 0.0216 0.0239 0.0326
Leishmania major cathepsin L-like protease 0.0064 0.0036 0.0317
Plasmodium vivax aspartyl proteinase, putative 0.0139 0.0135 0.3222
Onchocerca volvulus 0.0049 0.0016 0.0084
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0406 0.0493 0.0493
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0121 0.0112 0.0112
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0344 0.041 0.041
Loa Loa (eye worm) G-protein coupled receptor 0.0344 0.041 0.0561
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0344 0.041 0.0744
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0175 0.0184 0.7677
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0344 0.041 0.2525
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0406 0.0493 0.0493
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0406 0.0493 0.0674
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0344 0.041 0.041
Brugia malayi Dopamine receptor protein 2 0.0344 0.041 0.0561
Loa Loa (eye worm) hypothetical protein 0.0344 0.041 0.0561
Echinococcus granulosus epidermal growth factor receptor 0.0102 0.0086 0.0085
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0053 0.002 0.0036
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0279 0.0323 0.0322
Loa Loa (eye worm) hypothetical protein 0.0052 0.0019 0.0026
Loa Loa (eye worm) hypothetical protein 0.0062 0.0032 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0001 0.005
Leishmania major hypothetical protein, conserved 0.0039 0.0002 0.0021
Echinococcus multilocularis hypothetical protein 0.0095 0.0077 0.0077
Brugia malayi hypothetical protein 0.0344 0.041 0.0561
Loa Loa (eye worm) hypothetical protein 0.0988 0.1272 0.1739
Echinococcus multilocularis voltage dependent calcium channel 0.0121 0.0112 0.0112
Mycobacterium tuberculosis Conserved hypothetical protein 0.0463 0.057 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0344 0.041 0.041
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0018 0.0031
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0416 0.0507 0.4498
Brugia malayi hypothetical protein 0.0344 0.041 0.0561
Echinococcus granulosus Mastin 0.0216 0.0239 0.0238
Echinococcus granulosus glycine receptor subunit alpha 1 0.0406 0.0493 0.0493
Loa Loa (eye worm) hypothetical protein 0.0039 0.0002 0.0003
Plasmodium falciparum plasmepsin V 0.0139 0.0135 0.2091
Toxoplasma gondii PAN domain-containing protein 0.2229 0.2933 1
Plasmodium vivax aspartyl proteinase, putative 0.0217 0.024 0.5756
Echinococcus multilocularis nervana 2 0.0083 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0344 0.041 0.0561
Brugia malayi Variant SH3 domain containing protein 0.0052 0.0019 0.0026
Giardia lamblia Tenascin precursor 0.0175 0.0184 1
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0007 0.0012
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0139 0.0135 0.0185
Brugia malayi EGF-like domain containing protein 0.0175 0.0184 0.0252
Echinococcus multilocularis integrin alpha 3 0.0464 0.057 0.057
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0124 0.0115 0.1023
Schistosoma mansoni cercarial elastase (S01 family) 0.0216 0.0239 0.0432
Loa Loa (eye worm) hypothetical protein 0.0212 0.0234 0.0319
Toxoplasma gondii hypothetical protein 0.0142 0.014 0.0476
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0039 0.0002 0.0002
Onchocerca volvulus 0.0348 0.0416 0.2557
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0406 0.0493 0.0493
Echinococcus granulosus neuropeptide receptor 0.1174 0.152 0.152
Brugia malayi Muscleblind-like protein 0.0163 0.0168 0.0229
Echinococcus multilocularis integrin alpha ps 0.0401 0.0486 0.0486
Plasmodium falciparum plasmepsin VII 0.0139 0.0135 0.2091
Loa Loa (eye worm) hypothetical protein 0.0191 0.0206 0.0281
Plasmodium falciparum plasmepsin IV 0.0217 0.024 0.5048
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0215 0.0237 0.043
Echinococcus granulosus tyrosine protein kinase Fyn 0.0279 0.0323 0.0322
Loa Loa (eye worm) hypothetical protein 0.0175 0.0184 0.0252
Brugia malayi Metabotropic glutamate receptor precursor. 0.0066 0.0038 0.0051
Echinococcus multilocularis rhodopsin orphan GPCR 0.0344 0.041 0.041
Loa Loa (eye worm) hypothetical protein 0.0344 0.041 0.0561
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0406 0.0493 0.0895
Echinococcus multilocularis serotonin receptor 0.0344 0.041 0.041
Echinococcus granulosus hypothetical protein 0.0344 0.041 0.041
Brugia malayi hypothetical protein 0.0191 0.0206 0.0281
Toxoplasma gondii PAN domain-containing protein 0.0212 0.0234 0.0798
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0002 0.0003
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0191 0.0206 0.0281
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0344 0.041 0.0744
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0121 0.0112 0.0153
Loa Loa (eye worm) hypothetical protein 0.0344 0.041 0.0561
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0217 0.024 0.024
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0036 0.0317
Echinococcus granulosus tissue type plasminogen activator 0.0348 0.0416 0.0415
Echinococcus granulosus rhodopsin orphan GPCR 0.0344 0.041 0.041
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0105 0.0091 0.0124
Brugia malayi ORL1-like opioid receptor 0.0344 0.041 0.0561
Loa Loa (eye worm) hypothetical protein 0.0212 0.0234 0.0319
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0066 0.0038 0.0038
Schistosoma mansoni neuropeptide receptor 0.0344 0.041 0.0744
Loa Loa (eye worm) PAN domain-containing protein 0.0212 0.0234 0.0319
Loa Loa (eye worm) ACC-1 protein 0.0406 0.0493 0.0674
Loa Loa (eye worm) LGC-31 protein 0.0406 0.0493 0.0674
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0406 0.0493 0.0674
Loa Loa (eye worm) hypothetical protein 0.0406 0.0493 0.0674
Loa Loa (eye worm) hypothetical protein 0.0344 0.041 0.0561
Brugia malayi hypothetical protein 0.0191 0.0206 0.0281
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0406 0.0493 0.0674
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0016 0.0021
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0406 0.0493 0.0674
Echinococcus multilocularis integrin alpha ps 0.0401 0.0486 0.0486
Loa Loa (eye worm) hypothetical protein 0.0344 0.041 0.0561
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0036 0.0317
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0344 0.041 0.0744
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.088 0.1127 1
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0016 0.0021
Brugia malayi metabotropic glutamate receptor type 2 0.0066 0.0038 0.0051
Onchocerca volvulus 0.0049 0.0016 0.0084
Onchocerca volvulus 0.0212 0.0234 0.1433
Brugia malayi Protein kinase domain containing protein 0.0049 0.0016 0.0021
Echinococcus granulosus 7tm_1 domain containing protein 0.0344 0.041 0.041
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0036 0.0317
Onchocerca volvulus 0.0191 0.0206 0.1259
Loa Loa (eye worm) hypothetical protein 0.0191 0.0206 0.0281
Loa Loa (eye worm) TK protein kinase 0.0227 0.0253 0.0346
Echinococcus multilocularis serine:threonine protein kinase N2 0.0043 0.0007 0.0007
Onchocerca volvulus 0.0139 0.0135 0.0824
Schistosoma mansoni DNA polymerase gamma 0.0095 0.0077 0.014
Toxoplasma gondii microneme protein MIC17A 0.0212 0.0234 0.0798
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0344 0.041 0.041
Echinococcus multilocularis potassium voltage gated channel protein 0.0045 0.001 0.001
Plasmodium vivax aspartyl protease, putative 0.0139 0.0135 0.3222
Toxoplasma gondii aspartyl protease 0.0139 0.0135 0.0462
Loa Loa (eye worm) RGC/RGC protein kinase 0.0104 0.0089 0.0121
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0045 0.001 0.001
Onchocerca volvulus 0.0344 0.041 0.2525
Echinococcus granulosus kelch ECH associated protein 1 like 0.0097 0.008 0.0079
Entamoeba histolytica protein kinase, putative 0.013 0.0124 0.4911
Loa Loa (eye worm) hypothetical protein 0.0039 0.0002 0.0003
Schistosoma mansoni cercarial elastase (S01 family) 0.0216 0.0239 0.0432
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0083 0.0061 0.0545
Loa Loa (eye worm) TK/ROR protein kinase 0.0371 0.0447 0.061
Echinococcus granulosus sex peptide receptor 0.0344 0.041 0.041
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0006 0.0051
Schistosoma mansoni cercarial elastase (S01 family) 0.0216 0.0239 0.0432
Echinococcus granulosus potassium voltage gated channel protein 0.0525 0.0653 0.0652
Loa Loa (eye worm) hypothetical protein 0.0045 0.001 0.0013
Toxoplasma gondii microneme protein, putative 0.0212 0.0234 0.0798
Toxoplasma gondii PAN domain-containing protein 0.0212 0.0234 0.0798
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0216 0.0239 0.0432
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0503 0.0622 0.0622
Brugia malayi hypothetical protein 0.0139 0.0135 0.0185
Loa Loa (eye worm) hypothetical protein 0.0671 0.0848 0.1159
Loa Loa (eye worm) hypothetical protein 0.0406 0.0493 0.0674
Mycobacterium ulcerans hypothetical protein 0.0216 0.0239 0.4163
Schistosoma mansoni protein kinase 0.0209 0.0229 0.0415
Brugia malayi Protein kinase domain containing protein 0.0049 0.0016 0.0021
Onchocerca volvulus 0.0344 0.041 0.2525
Schistosoma mansoni hypothetical protein 0.0344 0.041 0.0744
Loa Loa (eye worm) hypothetical protein 0.0344 0.041 0.0561
Toxoplasma gondii DNA polymerase (pol2) superfamily protein 0.0043 0.0007 0.0024
Echinococcus multilocularis transmembrane protease serine 3 0.0216 0.0239 0.0238
Brugia malayi EGF-like domain containing protein 0.0175 0.0184 0.0252
Echinococcus multilocularis g protein coupled receptor 0.0344 0.041 0.041
Brugia malayi jmjC domain containing protein 0.0094 0.0076 0.0103
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0406 0.0493 0.0674
Schistosoma mansoni atypical protein kinase C 0.0043 0.0007 0.0012
Echinococcus granulosus neuropeptide s receptor 0.0344 0.041 0.041
Mycobacterium leprae Probable lipase LipE 0.0039 0.0002 0.5
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0002 0.0096
Echinococcus granulosus glycoprotein Antigen 5 0.0216 0.0239 0.0238
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0191 0.0206 0.0205
Loa Loa (eye worm) hypothetical protein 0.0344 0.041 0.0561
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0088 0.0068 0.0604
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0406 0.0493 0.0674
Brugia malayi EGF-like domain containing protein 0.0175 0.0184 0.0252
Loa Loa (eye worm) hypothetical protein 0.0066 0.0038 0.0051
Schistosoma mansoni amine GPCR 0.0344 0.041 0.0744
Trypanosoma cruzi Protein kinase B 0.0088 0.0068 0.0604
Brugia malayi Protein kinase domain containing protein 0.0049 0.0016 0.0021
Trypanosoma cruzi extracellular receptor, putative 0.0066 0.0038 0.0337
Loa Loa (eye worm) hypothetical protein 0.0139 0.0135 0.0185
Schistosoma mansoni metabotropic glutamate receptor 0.0066 0.0038 0.0068
Brugia malayi larval opioid receptor 0.0344 0.041 0.0561
Schistosoma mansoni neuropeptide F-like receptor 0.0344 0.041 0.0744
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0002 0.0003
Brugia malayi Cation transporter family protein 0.0406 0.0493 0.0674
Loa Loa (eye worm) hypothetical protein 0.0344 0.041 0.0561
Onchocerca volvulus 0.0344 0.041 0.2525
Brugia malayi PAN domain containing protein 0.0212 0.0234 0.0319
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0018 0.0017
Loa Loa (eye worm) RGC/RGC protein kinase 0.0209 0.0229 0.0313
Loa Loa (eye worm) hypothetical protein 0.0095 0.0077 0.0105
Echinococcus granulosus epidermal growth factor receptor 0.017 0.0177 0.0177
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0121 0.0112 0.0112
Schistosoma mansoni rotamase 0.0038 0.0001 0.0001
Schistosoma mansoni cercarial elastase (S01 family) 0.0216 0.0239 0.0432
Loa Loa (eye worm) hypothetical protein 0.0406 0.0493 0.0674
Echinococcus multilocularis glycine receptor subunit beta 0.0406 0.0493 0.0493
Brugia malayi Furin-like cysteine rich region family protein 0.017 0.0177 0.0242
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0068 0.004 0.0072
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0066 0.0038 0.0051
Brugia malayi beta-lactamase family protein 0.0039 0.0002 0.0003
Schistosoma mansoni opsin-like receptor 0.0344 0.041 0.0744
Loa Loa (eye worm) hypothetical protein 0.0212 0.0234 0.0319
Onchocerca volvulus 0.0215 0.0237 0.1454
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.1309 0.1702 0.3089
Echinococcus multilocularis rhodopsin orphan GPCR 0.0344 0.041 0.041
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0139 0.0135 0.0245
Echinococcus multilocularis protein kinase c epsilon type 0.0043 0.0007 0.0007
Brugia malayi PAN domain containing protein 0.0212 0.0234 0.0319
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0406 0.0493 0.0674
Loa Loa (eye worm) hypothetical protein 0.0406 0.0493 0.0674
Schistosoma mansoni hypothetical protein 0.0051 0.0018 0.0031
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0052 0.0019 0.0034
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0045 0.001 0.001
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0344 0.041 0.0744
Echinococcus granulosus neuropeptide Y receptor 0.0344 0.041 0.041
Echinococcus granulosus somatostatin receptor 0.0344 0.041 0.041
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0121 0.0112 0.0112
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0344 0.041 0.041
Onchocerca volvulus 0.0344 0.041 0.2525
Schistosoma mansoni alpha-1 adrenergic receptor 0.0344 0.041 0.0744
Leishmania major hypothetical protein, conserved 0.0348 0.0416 0.3688
Loa Loa (eye worm) hypothetical protein 0.0209 0.0229 0.0313
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0406 0.0493 0.0493
Schistosoma mansoni cercarial elastase (S01 family) 0.0216 0.0239 0.0432
Toxoplasma gondii hypothetical protein 0.0212 0.0234 0.0798
Brugia malayi Integrin beta pat-3 precursor 0.5503 0.7313 1
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0002 0.0021
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0016 0.0021
Plasmodium vivax DNA polymerase alpha, putative 0.0043 0.0007 0.0116
Brugia malayi G-protein coupled receptor 0.0344 0.041 0.0561
Loa Loa (eye worm) PAN domain-containing protein 0.0212 0.0234 0.0319
Brugia malayi hypothetical protein 0.0344 0.041 0.0561
Brugia malayi RE15519p 0.0344 0.041 0.0561
Toxoplasma gondii PAN/Apple domain-containing protein 0.0212 0.0234 0.0798
Plasmodium vivax plasmepsin V, putative 0.0139 0.0135 0.3222
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0139 0.0135 0.0245
Schistosoma mansoni tyrosine kinase 0.0079 0.0055 0.0099
Giardia lamblia High cysteine protein 0.0175 0.0184 1
Echinococcus multilocularis tyrosine protein kinase Blk 0.0253 0.0288 0.0288
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0083 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0191 0.0206 0.0281
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0406 0.0493 0.0493
Loa Loa (eye worm) hypothetical protein 0.0344 0.041 0.0561
Echinococcus granulosus neuropeptide Y receptor 0.0344 0.041 0.041
Loa Loa (eye worm) hypothetical protein 0.0073 0.0047 0.0064
Echinococcus multilocularis kelch ECH associated protein 1 0.0097 0.008 0.0079
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0191 0.0206 0.0205
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0016 0.0021
Onchocerca volvulus 0.0212 0.0234 0.1433
Echinococcus multilocularis nervana 2 0.0083 0.006 0.006
Schistosoma mansoni tyrosine kinase 0.0279 0.0323 0.0585
Onchocerca volvulus 0.0216 0.0239 0.1462
Loa Loa (eye worm) hypothetical protein 0.0191 0.0206 0.0281
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0043 0.0007 0.0009
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0016 0.0021
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0406 0.0493 0.0674
Loa Loa (eye worm) hypothetical protein 0.0344 0.041 0.0561
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0406 0.0493 0.0674
Schistosoma mansoni serine-type protease inhibitor 0.4153 0.5507 1
Loa Loa (eye worm) hypothetical protein 0.0191 0.0206 0.0281
Echinococcus multilocularis nAChR subunit 0.0406 0.0493 0.0493
Brugia malayi Protein kinase domain containing protein 0.0043 0.0007 0.0009
Brugia malayi aspartic protease BmAsp-1, identical 0.0139 0.0135 0.0185
Onchocerca volvulus 0.0049 0.0016 0.0084
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0344 0.041 0.0561
Giardia lamblia Tenascin-X 0.0175 0.0184 1
Onchocerca volvulus 0.0344 0.041 0.2525
Onchocerca volvulus 0.0344 0.041 0.2525
Loa Loa (eye worm) hypothetical protein 0.0191 0.0206 0.0281
Echinococcus granulosus potassium voltage gated channel protein 0.0045 0.001 0.001
Schistosoma mansoni tyrosine kinase 0.0089 0.0069 0.0124
Loa Loa (eye worm) hypothetical protein 0.0406 0.0493 0.0674
Onchocerca volvulus 0.0344 0.041 0.2525
Brugia malayi Eukaryotic aspartyl protease family protein 0.0139 0.0135 0.0185
Brugia malayi SEA domain containing protein 0.0181 0.0193 0.0263
Toxoplasma gondii microneme protein MIC17C 0.0212 0.0234 0.0798
Echinococcus granulosus integrin alpha 3 0.0464 0.057 0.057
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0344 0.041 0.041
Echinococcus granulosus orexin receptor type 2 0.0344 0.041 0.041
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0105 0.0091 0.0124
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.0076 0.0075
Echinococcus granulosus integrin alpha ps 0.0192 0.0207 0.0206
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.001 0.0018
Echinococcus multilocularis fibrillin 2 0.0175 0.0184 0.0184
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0212 0.0234 0.0798
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0049 0.0016 0.0015
Loa Loa (eye worm) hypothetical protein 0.0344 0.041 0.0561
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0344 0.041 0.0561
Schistosoma mansoni cercarial elastase (S01 family) 0.0216 0.0239 0.0432
Brugia malayi Tyrosine-protein kinase abl-1 0.0075 0.005 0.0068
Echinococcus multilocularis Mastin 0.0216 0.0239 0.0238
Brugia malayi hypothetical protein 0.0191 0.0206 0.0281
Brugia malayi hypothetical protein 0.0191 0.0206 0.0281
Toxoplasma gondii subtilisin SUB12 0.0212 0.0234 0.0798
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0124 0.0115 0.1023
Echinococcus granulosus glutamate receptor 2 0.0066 0.0038 0.0038
Schistosoma mansoni integrin alpha-ps 0.0209 0.0229 0.0415
Loa Loa (eye worm) hypothetical protein 0.0344 0.041 0.0561
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0139 0.0135 0.0245
Brugia malayi PAN domain containing protein 0.0212 0.0234 0.0319
Loa Loa (eye worm) AGC/PKN protein kinase 0.0043 0.0007 0.0009
Schistosoma mansoni tyrosine kinase 0.0671 0.0848 0.1539
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0045 0.001 0.001
Brugia malayi CUB domain containing protein 0.0062 0.0032 0.0044
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0216 0.0239 0.0238
Schistosoma mansoni growth factor receptor-bound protein 0.0052 0.0019 0.0034
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0406 0.0493 0.0493
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0406 0.0493 0.0674
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.001 0.0018
Loa Loa (eye worm) aspartyl protease 6 0.0139 0.0135 0.0185
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0007 0.0305
Schistosoma mansoni nck2/grb4 0.0052 0.0019 0.0034
Schistosoma mansoni adapter molecule crk 0.0052 0.0019 0.0034
Schistosoma mansoni myosin xvIII 0.0344 0.041 0.0744
Schistosoma mansoni opsin-like receptor 0.0344 0.041 0.0744
Brugia malayi SRC-1 0.0279 0.0323 0.0441
Echinococcus granulosus glycine receptor subunit alpha 1 0.0406 0.0493 0.0493
Onchocerca volvulus 0.0175 0.0184 0.1127
Trypanosoma brucei mitochondrial DNA polymerase beta 0.088 0.1127 1
Echinococcus multilocularis voltage dependent calcium channel 0.0121 0.0112 0.0112
Onchocerca volvulus 0.1032 0.133 0.8213
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0216 0.0239 0.0326
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0083 0.0061 0.0061
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0279 0.0323 0.0322
Brugia malayi hypothetical protein 0.0344 0.041 0.0561
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0344 0.041 0.041
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0406 0.0493 0.0674
Echinococcus multilocularis epidermal growth factor receptor 0.0102 0.0086 0.0085
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0191 0.0206 0.0205
Loa Loa (eye worm) hypothetical protein 0.0191 0.0206 0.0281
Leishmania major hypothetical protein, conserved 0.0042 0.0006 0.0051
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0139 0.0135 0.0245
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0066 0.0038 0.0038
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0344 0.041 0.0744
Brugia malayi Pepsin A precursor 0.0139 0.0135 0.0185
Echinococcus granulosus voltage gated potassium channel 0.0045 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0344 0.041 0.0561
Brugia malayi Receptor family ligand binding region containing protein 0.0066 0.0038 0.0051
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0075 0.005 0.005
Echinococcus granulosus tyrosine protein kinase Src64B 0.0279 0.0323 0.0322
Echinococcus granulosus glycine receptor subunit beta 0.0406 0.0493 0.0493
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0344 0.041 0.0744
Loa Loa (eye worm) acetylcholine receptor protein 0.0191 0.0206 0.0281
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0406 0.0493 0.0493
Loa Loa (eye worm) hypothetical protein 0.0344 0.041 0.0561
Loa Loa (eye worm) hypothetical protein 0.019 0.0204 0.0278
Schistosoma mansoni memapsin-2 (A01 family) 0.196 0.2572 0.4669
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0988 0.1272 0.231
Brugia malayi beta-lactamase 0.0039 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0216 0.0239 0.0326
Loa Loa (eye worm) trypsin family protein 0.0216 0.0239 0.0326
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0344 0.041 0.0561
Onchocerca volvulus 0.0212 0.0234 0.1433
Onchocerca volvulus 0.0212 0.0234 0.1433
Plasmodium falciparum plasmepsin VI 0.0217 0.024 0.5048
Echinococcus multilocularis glutamate receptor 2 0.0066 0.0038 0.0038
Schistosoma mansoni tyrosine kinase 0.0075 0.005 0.009
Loa Loa (eye worm) hypothetical protein 0.0066 0.0038 0.0051
Entamoeba histolytica PH domain containing protein kinase, putative 0.0088 0.0068 0.2687
Echinococcus multilocularis serine:threonine protein kinase 38 0.0043 0.0007 0.0007
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0191 0.0206 0.0205
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0191 0.0206 0.0281
Echinococcus multilocularis Kelch repeat type 1 0.0098 0.008 0.008
Toxoplasma gondii aspartyl protease ASP1 0.0217 0.024 0.0819
Loa Loa (eye worm) hypothetical protein 0.0121 0.0112 0.0153
Brugia malayi Receptor family ligand binding region containing protein 0.0209 0.0229 0.0313
Onchocerca volvulus 0.0406 0.0493 0.3038
Brugia malayi PAN domain containing protein 0.0212 0.0234 0.0319
Toxoplasma gondii AGC kinase 0.0126 0.0118 0.0401
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0045 0.001 0.001
Toxoplasma gondii PAN domain-containing protein 0.0212 0.0234 0.0798
Schistosoma mansoni voltage-gated potassium channel 0.0525 0.0653 0.1185
Brugia malayi SH2 domain containing protein 0.0049 0.0016 0.0021
Echinococcus multilocularis transfer RNA-Gly 0.0045 0.001 0.001
Brugia malayi Cation transporter family protein 0.0406 0.0493 0.0674
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0124 0.0115 0.1023
Loa Loa (eye worm) integrin alpha pat-2 0.0833 0.1064 0.1454
Echinococcus granulosus rhodopsin orphan GPCR 0.0344 0.041 0.041
Leishmania major mitochondrial DNA polymerase beta 0.088 0.1127 1
Schistosoma mansoni tyrosine kinase 0.017 0.0177 0.0321
Onchocerca volvulus 0.0344 0.041 0.2525
Echinococcus multilocularis dro:myosuppressin receptor 0.0344 0.041 0.041
Loa Loa (eye worm) SRC-1 0.0279 0.0323 0.0441
Brugia malayi Cation transporter family protein 0.0988 0.1272 0.1739
Plasmodium vivax aspartyl protease, putative 0.0139 0.0135 0.3222
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0406 0.0493 0.0895
Brugia malayi SH2 domain containing protein 0.0049 0.0016 0.0021
Brugia malayi Protein kinase domain containing protein 0.0049 0.0016 0.0021
Trypanosoma cruzi hypothetical protein, conserved 0.0348 0.0416 0.3688
Onchocerca volvulus 0.0344 0.041 0.2525
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0016 0.0021
Echinococcus multilocularis shaker cognate 0.0045 0.001 0.001
Brugia malayi beta-lactamase family protein 0.0039 0.0002 0.0003
Onchocerca volvulus 0.0216 0.0239 0.1462
Loa Loa (eye worm) hypothetical protein 0.0066 0.0038 0.0051
Loa Loa (eye worm) hypothetical protein 0.0344 0.041 0.0561
Trichomonas vaginalis AGC family protein kinase 0.013 0.0124 0.5177
Loa Loa (eye worm) AGC/NDR protein kinase 0.0043 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0191 0.0206 0.0281
Echinococcus multilocularis tyrosine kinase 0.0089 0.0069 0.0068
Onchocerca volvulus 0.0191 0.0206 0.1259
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0066 0.0038 0.0038
Echinococcus multilocularis receptor type guanylyl cyclase 0.0209 0.0229 0.0229
Schistosoma mansoni hypothetical protein 0.0216 0.0239 0.0432
Loa Loa (eye worm) hypothetical protein 0.0406 0.0493 0.0674
Loa Loa (eye worm) hypothetical protein 0.0105 0.0091 0.0124
Schistosoma mansoni neuropeptide receptor 0.0344 0.041 0.0744
Echinococcus granulosus tyrosine protein kinase Fyn 0.0279 0.0323 0.0322
Loa Loa (eye worm) hypothetical protein 0.0406 0.0493 0.0674
Leishmania major extracellular receptor, putative 0.0066 0.0038 0.0337
Giardia lamblia Neurogenic locus notch-like protein 0.0175 0.0184 1
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0043 0.0007 0.0007
Schistosoma mansoni serine-type protease inhibitor 0.4153 0.5507 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0018 0.0031
Echinococcus multilocularis neuropeptide receptor 0.0344 0.041 0.041
Echinococcus multilocularis rhodopsin orphan GPCR 0.0344 0.041 0.041
Onchocerca volvulus 0.0212 0.0234 0.1433
Schistosoma mansoni acetylcholine receptor-related 0.0191 0.0206 0.0373
Loa Loa (eye worm) hypothetical protein 0.0066 0.0038 0.0051
Loa Loa (eye worm) hypothetical protein 0.0049 0.0016 0.0021
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0279 0.0323 0.0322
Echinococcus granulosus receptor type guanylyl cyclase 0.0209 0.0229 0.0229
Echinococcus granulosus neuropeptide FF receptor 2 0.0344 0.041 0.041
Onchocerca volvulus 0.0212 0.0234 0.1433
Loa Loa (eye worm) hypothetical protein 0.0215 0.0237 0.0324
Brugia malayi G protein-coupled receptor 0.0344 0.041 0.0561
Loa Loa (eye worm) hypothetical protein 0.0344 0.041 0.0561
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0217 0.024 0.0819
Plasmodium vivax aspartyl protease, putative 0.0139 0.0135 0.3222
Onchocerca volvulus 0.0406 0.0493 0.3038
Trichomonas vaginalis AGC family protein kinase 0.013 0.0124 0.5177
Entamoeba histolytica PH domain containing protein kinase, putative 0.0088 0.0068 0.2687
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0344 0.041 0.0744
Onchocerca volvulus 0.0049 0.0016 0.0084
Loa Loa (eye worm) hypothetical protein 0.0212 0.0234 0.0319
Onchocerca volvulus 0.0216 0.0239 0.1462
Schistosoma mansoni hypothetical protein 0.0072 0.0046 0.0083
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0036 0.0317
Echinococcus multilocularis fmrfamide receptor 0.0344 0.041 0.041
Loa Loa (eye worm) hypothetical protein 0.0191 0.0206 0.0281
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0406 0.0493 0.0493
Schistosoma mansoni nAChR subunit 0.0191 0.0206 0.0373
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0344 0.041 0.0744
Onchocerca volvulus 0.0181 0.0193 0.1177
Onchocerca volvulus 0.0988 0.1272 0.7857
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0018 0.0031
Onchocerca volvulus 0.0216 0.0239 0.1462
Onchocerca volvulus 0.0344 0.041 0.2525
Loa Loa (eye worm) hypothetical protein 0.0344 0.041 0.0561
Loa Loa (eye worm) hypothetical protein 0.0089 0.0069 0.0094
Loa Loa (eye worm) PAN domain-containing protein 0.0212 0.0234 0.0319
Brugia malayi Melatonin receptor type 1A 0.0344 0.041 0.0561
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0018 0.0017
Echinococcus multilocularis rac serine:threonine kinase 0.0088 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0344 0.041 0.0561
Plasmodium falciparum cysteine repeat modular protein 1 0.0348 0.0416 1
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0007 0.0012
Loa Loa (eye worm) hypothetical protein 0.0215 0.0237 0.0324
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0016 0.0021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0036 0.0317
Echinococcus granulosus glutamate receptor 2 0.0066 0.0038 0.0038
Brugia malayi hypothetical protein 0.0191 0.0206 0.0281
Echinococcus granulosus adam 0.0175 0.0184 0.0184
Brugia malayi PAN domain containing protein 0.0212 0.0234 0.0319
Loa Loa (eye worm) TK/EGFR protein kinase 0.017 0.0177 0.0242
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0002 0.0096
Loa Loa (eye worm) neuropeptide F receptor 0.0344 0.041 0.0561
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0344 0.041 0.0561
Brugia malayi Serotonin receptor 0.0344 0.041 0.0561
Echinococcus multilocularis neuropeptide Y receptor 0.0344 0.041 0.041
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0216 0.0239 0.0432
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0066 0.0038 0.0051
Echinococcus granulosus G protein coupled receptor 139 0.0344 0.041 0.041
Loa Loa (eye worm) hypothetical protein 0.0272 0.0313 0.0428
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0007 0.0012
Schistosoma mansoni opsin-like receptor 0.0344 0.041 0.0744
Schistosoma mansoni cercarial elastase (S01 family) 0.0216 0.0239 0.0432
Echinococcus granulosus activated cdc42 kinase 1 0.1707 0.2234 0.2233
Echinococcus granulosus serine threonine protein kinase nrc 0.0083 0.0061 0.0061
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0121 0.0112 0.0203
Entamoeba histolytica protein kinase, putative 0.0227 0.0253 1
Onchocerca volvulus 0.0049 0.0016 0.0084
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0191 0.0206 0.0281
Loa Loa (eye worm) hypothetical protein 0.0216 0.0239 0.0326
Schistosoma mansoni nAChR subunit 0.0406 0.0493 0.0895
Loa Loa (eye worm) hypothetical protein 0.0344 0.041 0.0561
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0016 0.0021
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.001 0.0018
Echinococcus granulosus DNA polymerase alpha catalytic subunit 0.0053 0.002 0.002
Echinococcus multilocularis glutamate receptor 2 0.0066 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0344 0.041 0.0561
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0036 0.0317
Brugia malayi Trypsin family protein 0.0216 0.0239 0.0326
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0344 0.041 0.041
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0063 0.0034 0.0033
Loa Loa (eye worm) hypothetical protein 0.0797 0.1016 0.1389
Brugia malayi PAN domain containing protein 0.0212 0.0234 0.0319
Schistosoma mansoni tyrosine kinase 0.0102 0.0086 0.0155
Loa Loa (eye worm) hypothetical protein 0.0344 0.041 0.0561
Echinococcus granulosus serine/threonine protein kinase 0.0088 0.0068 0.0068
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0043 0.0007 0.0009
Schistosoma mansoni integrin alpha 0.0673 0.085 0.1542
Loa Loa (eye worm) hypothetical protein 0.0406 0.0493 0.0674
Echinococcus granulosus fibrillin 1 0.0175 0.0184 0.0184
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0018 0.0023
Onchocerca volvulus DNA polymerase alpha catalytic subunit homolog 0.0073 0.0047 0.0276
Schistosoma mansoni tyrosine kinase 0.0066 0.0038 0.0067
Echinococcus multilocularis potassium voltage gated channel protein 0.0525 0.0653 0.0652
Loa Loa (eye worm) hypothetical protein 0.0344 0.041 0.0561
Onchocerca volvulus 0.0344 0.041 0.2525
Giardia lamblia High cysteine protein 0.0175 0.0184 1
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0217 0.024 0.0328
Brugia malayi Integrin alpha pat-2 precursor 0.0673 0.085 0.1161
Schistosoma mansoni amine GPCR 0.0344 0.041 0.0744
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0014 0.0581
Brugia malayi Muscle positioning protein 4 0.019 0.0204 0.0278
Echinococcus granulosus neuropeptide receptor A26 0.0344 0.041 0.041
Echinococcus multilocularis rhodopsin orphan GPCR 0.0344 0.041 0.041
Brugia malayi Protein kinase domain containing protein 0.0371 0.0447 0.061
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0253 0.0288 0.0288
Loa Loa (eye worm) hypothetical protein 0.0041 0.0005 0.0006
Echinococcus granulosus nAChR subunit 0.0215 0.0237 0.0237
Echinococcus granulosus biogenic amine 5HT receptor 0.0344 0.041 0.041
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0344 0.041 0.041
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0002 0.0003
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0045 0.001 0.001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0344 0.041 0.0744
Trichomonas vaginalis AGC family protein kinase 0.013 0.0124 0.5177
Echinococcus multilocularis integrin alpha ps 0.0192 0.0207 0.0206
Brugia malayi Trypsin family protein 0.0216 0.0239 0.0326
Brugia malayi putative neuropeptide receptor NPR1 0.0344 0.041 0.0561
Loa Loa (eye worm) hypothetical protein 0.0344 0.041 0.0561
Echinococcus granulosus tyrosine protein kinase Src42A 0.0279 0.0323 0.0322
Onchocerca volvulus 0.0066 0.0038 0.0221
Echinococcus granulosus intersectin 2 0.0042 0.0006 0.0005
Brugia malayi Protein kinase domain containing protein 0.013 0.0124 0.0169
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0416 0.0507 0.4498
Loa Loa (eye worm) hypothetical protein 0.0882 0.113 0.1545
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0052 0.0019 0.0026
Brugia malayi neuropeptide F receptor 0.0344 0.041 0.0561
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.1247 0.1619 0.2939
Schistosoma mansoni tyrosine kinase 0.007 0.0043 0.0077
Loa Loa (eye worm) hypothetical protein 0.0406 0.0493 0.0674
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0344 0.041 0.041
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0217 0.024 0.0435
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0406 0.0493 0.0493
Echinococcus multilocularis activated cdc42 kinase 1 0.1707 0.2234 0.2233
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0139 0.0135 0.0245
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0018 0.0017
Schistosoma mansoni cercarial elastase (S01 family) 0.0216 0.0239 0.0432
Loa Loa (eye worm) hypothetical protein 0.0344 0.041 0.0561
Loa Loa (eye worm) hypothetical protein 0.0191 0.0206 0.0281
Echinococcus granulosus nAChR subunit 0.0406 0.0493 0.0493
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0043 0.0007 0.0009
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0344 0.041 0.041
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0344 0.041 0.041
Loa Loa (eye worm) calcium channel 0.0121 0.0112 0.0153
Echinococcus granulosus rhodopsin orphan GPCR 0.0344 0.041 0.041
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0043 0.0007 0.0007
Echinococcus granulosus tyrosine protein kinase Src42A 0.0246 0.0279 0.0279
Onchocerca volvulus 0.0212 0.0234 0.1433
Schistosoma mansoni cathepsin D (A01 family) 0.0417 0.0508 0.0921
Schistosoma mansoni nAChR subunit 0.0406 0.0493 0.0895
Schistosoma mansoni cercarial elastase (S01 family) 0.0216 0.0239 0.0432
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0406 0.0493 0.0493
Onchocerca volvulus 0.0104 0.0089 0.0535
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0082 0.0059 0.0523
Echinococcus granulosus serotonin receptor 0.0344 0.041 0.041
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0082 0.0059 0.0523
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0121 0.0112 0.0203
Echinococcus multilocularis somatostatin receptor 0.0344 0.041 0.041
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0083 0.006 0.006
Echinococcus multilocularis insulin receptor 0.007 0.0043 0.0042
Schistosoma mansoni integrin alpha-ps 0.0401 0.0486 0.0882
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0036 0.0317
Schistosoma mansoni biogenic amine (5HT) receptor 0.0344 0.041 0.0744
Plasmodium falciparum plasmepsin I 0.0217 0.024 0.5048
Brugia malayi Trypsin-like protease protein 5 0.0216 0.0239 0.0326
Mycobacterium ulcerans hypothetical protein 0.0463 0.057 1
Loa Loa (eye worm) hypothetical protein 0.0191 0.0206 0.0281
Onchocerca volvulus 0.0139 0.0135 0.0824
Schistosoma mansoni hypothetical protein 0.0344 0.041 0.0744
Schistosoma mansoni tyrosine kinase 0.0049 0.0016 0.0028
Loa Loa (eye worm) hypothetical protein 0.0066 0.0038 0.0051
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0344 0.041 0.0744
Loa Loa (eye worm) hypothetical protein 0.0215 0.0237 0.0324
Loa Loa (eye worm) hypothetical protein 0.0406 0.0493 0.0674
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0043 0.0007 0.0007
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0344 0.041 0.0744
Trichomonas vaginalis rotamase, putative 0.0038 0.0001 0.005
Schistosoma mansoni nAChR subunit 0.0406 0.0493 0.0895
Brugia malayi Kelch motif family protein 0.0911 0.1168 0.1597
Echinococcus multilocularis fmrfamide receptor 0.0344 0.041 0.041
Brugia malayi p70 ribosomal S6 kinase beta 0.0126 0.0118 0.016
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0066 0.0038 0.0038
Brugia malayi protein-tyrosine kinase 0.0253 0.0288 0.0394
Loa Loa (eye worm) hypothetical protein 0.0348 0.0416 0.0568
Brugia malayi Protein kinase domain containing protein 0.0043 0.0007 0.0009
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.007 0.0043 0.0042
Echinococcus granulosus fibrillin 2 0.0175 0.0184 0.0184
Echinococcus granulosus insulin receptor 0.007 0.0043 0.0042
Loa Loa (eye worm) hypothetical protein 0.1707 0.2234 0.3054
Schistosoma mansoni biogenic amine receptor 0.0344 0.041 0.0744

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 1.25 uM Inhibition of MCF-7 (breast) cancer cell proliferation ChEMBL. 11206452
IC50 (functional) = 2 uM Inhibition of NIH3T3 cell proliferation ChEMBL. 11206452
IC50 (binding) = 5 uM Inhibition of Akt (proto-oncogenic serine/threonine) kinase ChEMBL. 11206452
IC50 (functional) = 10 uM Tested in vitro for their inhibitory activity against PC-3(prostrate) cell line. ChEMBL. 10956212
IC50 (functional) = 10 uM Inhibition of human colon carcinoma (HT-29) cell proliferation ChEMBL. 11206452
IC50 (functional) = 12 uM Tested in vitro for their inhibitory activity against HT-29 (colon) cell line ChEMBL. 10956212
IC50 (functional) = 12.5 uM Tested in vitro for their inhibitory activity against MCF-7(breast) cell line ChEMBL. 10956212
IC50 (functional) > 20 uM Tested in vitro for their inhibitory activity against Hela(cervical) cell line ChEMBL. 10956212
IC50 (binding) = 32 uM Inhibition of Akt (proto-oncogenic serine/threonine PKB) kinase ChEMBL. 10956212
IC50 (binding) = 83 uM Inhibition of p100/p85 PI3-kinase (phosphatidylinositol 3-kinase) ChEMBL. 11206452
Ratio (binding) = 5 Inhibition of protein kinase B (Akt) PH domain ChEMBL. 11300871
Ratio (binding) = 32 Inhibition of protein kinase B (Akt) PH domain ChEMBL. 11300871

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 10956212
Mus musculus ChEMBL23 11206452

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

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