Detailed information for compound 1747777

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 405.455 | Formula: C19H30F3N3O3
  • H donors: 2 H acceptors: 3 LogP: 3.09 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC([C@@H](C(=O)C(F)(F)F)NC(=O)[C@H]1C2CCC(N1C(=O)[C@H](C(C)C)N)CC2)C
  • InChi: 1S/C19H30F3N3O3/c1-9(2)13(23)18(28)25-12-7-5-11(6-8-12)15(25)17(27)24-14(10(3)4)16(26)19(20,21)22/h9-15H,5-8,23H2,1-4H3,(H,24,27)/t11?,12?,13-,14-,15+/m0/s1
  • InChiKey: VQWAJWSTRTYSGL-QXRZNBQRSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens elastase, neutrophil expressed Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus transmembrane protease serine 3 elastase, neutrophil expressed 267 aa 236 aa 27.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0043 0.0074 0.0074
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0041 0.007 0.007
Brugia malayi hypothetical protein 0.0019 0.0024 0.0024
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0064 0.0765
Echinococcus granulosus expressed conserved protein 0.0098 0.019 0.019
Brugia malayi Probable DNA topoisomerase II 0.0019 0.0024 0.0024
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0082 0.0082
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.005 0.1465
Plasmodium vivax ataxin-2 like protein, putative 0.0076 0.0143 0.6851
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0024
Echinococcus multilocularis transcription factor btf3 0.0102 0.0199 0.0199
Loa Loa (eye worm) hypothetical protein 0.0041 0.007 0.007
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0143 0.7155
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0178 0.8915
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0024 0.0024
Echinococcus multilocularis Niemann Pick C1 protein 0.0104 0.0204 0.0204
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0041 0.007 0.007
Echinococcus multilocularis GPCR, family 2 0.0031 0.0048 0.0048
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0064 0.0064
Echinococcus granulosus GPCR family 2 0.0031 0.0048 0.0048
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0019 0.0024 0.0065
Echinococcus granulosus tar DNA binding protein 0.0123 0.0243 0.0243
Brugia malayi Isocitrate dehydrogenase 0.0046 0.0081 0.0081
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0041 0.007 0.007
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0019 0.0024 0.0069
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.005 0.2375
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0178 0.2944
Brugia malayi beta-NAC-like protein 0.0102 0.0199 0.0199
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0048 0.0048
Toxoplasma gondii heat shock protein HSP90 0.0095 0.0183 0.9221
Leishmania major mitochondrial DNA topoisomerase II 0.0019 0.0024 0.1023
Trichomonas vaginalis heat shock protein, putative 0.0075 0.0143 0.2276
Loa Loa (eye worm) hypothetical protein 0.0025 0.0036 0.0036
Schistosoma mansoni patched 1 0.0045 0.0078 0.0078
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0064 0.0064
Onchocerca volvulus 0.0041 0.007 0.2761
Leishmania major developmentally regulated phosphoprotein-like protein 0.0019 0.0024 0.1023
Trypanosoma cruzi heat shock protein, putative 0.0039 0.0065 0.3144
Echinococcus multilocularis protein patched 0.0045 0.0078 0.0078
Plasmodium falciparum endoplasmin, putative 0.0058 0.0106 0.4733
Loa Loa (eye worm) hypothetical protein 0.0076 0.0143 0.0143
Schistosoma mansoni RAR-like nuclear receptor 0.0041 0.007 0.007
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0024 0.0757
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.0023
Onchocerca volvulus Huntingtin homolog 0.0119 0.0234 1
Plasmodium falciparum heat shock protein 90, putative 0.0039 0.0065 0.2413
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0024
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.0468 0.0468
Brugia malayi CHE-14 protein 0.0045 0.0078 0.0078
Brugia malayi nuclear receptor NHR-88 0.0019 0.0024 0.0024
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.0178 0.751
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0086 0.0086
Schistosoma mansoni hypothetical protein 0.0031 0.0048 0.0048
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0024
Leishmania major heat shock protein 83-1 0.0095 0.0183 0.9221
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0019 0.0024 0.0069
Schistosoma mansoni DNA topoisomerase II 0.0019 0.0024 0.0024
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0024 0.0024
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0143 0.6851
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0019 0.0024 0.0022
Brugia malayi Steroid receptor seven-up type 2 0.0041 0.007 0.007
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0048 0.0048
Plasmodium vivax heat shock protein, putative 0.0039 0.0065 0.2413
Toxoplasma gondii Hsp90 domain-containing protein 0.0039 0.0065 0.3144
Trypanosoma brucei polo-like protein kinase 0.0092 0.0178 0.8915
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0019 0.0024 1
Loa Loa (eye worm) glutaminase 2 0.0266 0.0545 0.0545
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.005 0.2375
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0059 0.2815
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0024 0.0757
Loa Loa (eye worm) hypothetical protein 0.0022 0.0029 0.0029
Trichomonas vaginalis rotamase, putative 0.0033 0.0052 0.0535
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.007 0.007
Toxoplasma gondii heat shock protein 75, putative 0.0039 0.0065 0.3144
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0046 0.0081 0.0081
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0064 0.0904
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0024
Entamoeba histolytica hypothetical protein 0.0035 0.0057 0.1833
Plasmodium falciparum heat shock protein 90, putative 0.0039 0.0065 0.2413
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0059 0.2815
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0001 0.0001
Loa Loa (eye worm) endoplasmin 0.0095 0.0183 0.0183
Onchocerca volvulus 0.0052 0.0094 0.3833
Trypanosoma brucei heat shock protein 90, putative 0.0095 0.0183 0.9221
Schistosoma mansoni tar DNA-binding protein 0.0123 0.0243 0.0243
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0024
Giardia lamblia Heat shock protein HSP 90-alpha 0.0075 0.0143 0.7443
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.005 0.2375
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0041 0.007 0.007
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0019 0.0024 0.0069
Leishmania major hypothetical protein, conserved 0.0076 0.0143 0.7155
Loa Loa (eye worm) TOPoisomerase family member 0.0019 0.0024 0.0024
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0038 0.0064 0.0064
Mycobacterium ulcerans beta-lactamase 0.0038 0.0064 0.0785
Mycobacterium ulcerans lipase LipD 0.0038 0.0064 0.0785
Onchocerca volvulus Protein ultraspiracle homolog 0.0041 0.007 0.2761
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0019 0.0024 0.0022
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0064 0.0785
Schistosoma mansoni endoplasmin 0.0095 0.0183 0.0183
Brugia malayi kinase, mitochondrial precursor 0.0019 0.0024 0.0024
Entamoeba histolytica hypothetical protein 0.0035 0.0057 0.1833
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM10, putative 0.0046 0.0081 0.3309
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0086 0.0086
Entamoeba histolytica hypothetical protein 0.0035 0.0057 0.1833
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.007 0.007
Brugia malayi nuclear receptor RXR 0.0019 0.0024 0.0024
Brugia malayi conserved hypotetical protein 0.0019 0.0024 0.0024
Schistosoma mansoni thyroid hormone receptor 0.0041 0.007 0.007
Trypanosoma cruzi heat shock protein 85, putative 0.0075 0.0143 0.7124
Mycobacterium ulcerans heat shock protein 90 0.0075 0.0143 0.2293
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0036 0.0326
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0057 0.0057
Brugia malayi RNA recognition motif domain containing protein 0.0123 0.0243 0.0243
Leishmania major heat shock protein, putative 0.0039 0.0065 0.3144
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0108 0.0108
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0019 0.0024 0.1023
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0059 0.2815
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.007 0.007
Leishmania major heat shock protein 83-1 0.0095 0.0183 0.9221
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0019 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.0023
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0039 0.0065 0.2575
Schistosoma mansoni lamin 0.0052 0.0094 0.0094
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0059 0.3952
Schistosoma mansoni hypothetical protein 0.0043 0.0074 0.0074
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0064 0.3073
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0036 0.0326
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.0034 0.0055 0.0055
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0046 0.0081 0.393
Trichomonas vaginalis heat shock protein, putative 0.0039 0.0065 0.0791
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.005 0.2375
Loa Loa (eye worm) hypothetical protein 0.0031 0.0048 0.0048
Echinococcus granulosus lamin 0.0052 0.0094 0.0094
Brugia malayi intermediate filament protein 0.0052 0.0094 0.0094
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0046 0.0081 0.3283
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.0055 0.0055
Trichomonas vaginalis heat shock protein, putative 0.0075 0.0143 0.2276
Brugia malayi nuclear hormone receptor 0.0041 0.007 0.007
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0029 0.0029
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0024
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0064 0.0904
Toxoplasma gondii TIM10 family protein, putative 0.0046 0.0081 0.3953
Loa Loa (eye worm) steroid hormone receptor 0.0041 0.007 0.007
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0041 0.007 0.007
Brugia malayi heat shock protein 90 0.0095 0.0183 0.0183
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.007 0.007
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0036 0.1033
Loa Loa (eye worm) inositol-1 0.0036 0.0059 0.0059
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0064 0.0785
Plasmodium falciparum basic transcription factor 3b, putative 0.0102 0.0199 1
Schistosoma mansoni retinoic acid receptor RXR 0.0041 0.007 0.007
Schistosoma mansoni cpg binding protein 0.0029 0.0045 0.0045
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.0024 0.0024
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0046 0.0081 0.393
Loa Loa (eye worm) heat shock protein 90 0.0095 0.0183 0.0183
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0064 0.3073
Loa Loa (eye worm) TAR-binding protein 0.0123 0.0243 0.0243
Trypanosoma brucei transcription factor BTF3, putative 0.0102 0.0199 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0041 0.007 0.007
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0036 0.1653
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.0024 0.0024
Plasmodium vivax heat shock protein 86, putative 0.0095 0.0183 0.9138
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0046 0.0081 0.0081
Leishmania major heat shock protein 83-1 0.0095 0.0183 0.9221
Leishmania major heat shock protein 83-1 0.0095 0.0183 0.9221
Brugia malayi hypothetical protein 0.0119 0.0234 0.0234
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0019 0.0024 0.0024
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0178 0.2944
Loa Loa (eye worm) hypothetical protein 0.0041 0.007 0.007
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.0024 0.0024
Echinococcus multilocularis musashi 0.0052 0.0094 0.0094
Trypanosoma cruzi heat shock protein 90, putative 0.0056 0.0101 0.5002
Schistosoma mansoni inositol monophosphatase 0.0036 0.0059 0.0059
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0064 0.336
Mycobacterium tuberculosis Conserved protein 0.0038 0.0064 0.0904
Schistosoma mansoni hypothetical protein 0.0031 0.0048 0.0048
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.0468 0.0468
Brugia malayi hypothetical protein 0.0022 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0024
Mycobacterium tuberculosis Conserved protein 0.0019 0.0024 0.0069
Trypanosoma brucei heat shock protein, putative 0.0095 0.0183 0.9221
Schistosoma mansoni hypothetical protein 0.0066 0.0123 0.0123
Echinococcus granulosus intermediate filament protein 0.0052 0.0094 0.0094
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.005 0.2375
Loa Loa (eye worm) hypothetical protein 0.0024 0.0035 0.0035
Loa Loa (eye worm) DR-78 0.0019 0.0024 0.0024
Mycobacterium ulcerans hypothetical protein 0.0038 0.0064 0.0785
Leishmania major hypothetical protein, conserved 0.0038 0.0064 0.3073
Toxoplasma gondii mitochondrial import inner membrane translocase subunit TIM10, putative 0.0046 0.0081 0.3953
Schistosoma mansoni cpg binding protein 0.0028 0.0042 0.0042
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.0188 0.0188
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0178 0.2944
Echinococcus granulosus lamin dm0 0.0052 0.0094 0.0094
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0051 0.0633
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0036 0.0257
Trichomonas vaginalis heat shock protein, putative 0.0075 0.0143 0.2276
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0064 0.0765
Echinococcus granulosus Niemann Pick C1 protein 0.0149 0.0298 0.0298
Trypanosoma brucei heat shock protein, putative 0.0095 0.0183 0.9221
Brugia malayi nuclear receptor NHR-88 0.0041 0.007 0.007
Toxoplasma gondii isocitrate dehydrogenase 0.0046 0.0081 0.393
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0024
Brugia malayi isocitrate dehydrogenase 0.0046 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0066 0.0123 0.0123
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0019 0.0024 0.0069
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.0024 0.0024
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0042 0.0042
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0036 0.1653
Toxoplasma gondii isocitrate dehydrogenase 0.0046 0.0081 0.393
Mycobacterium ulcerans hypothetical protein 0.0025 0.0036 0.0257
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0059 0.0669
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0019 0.0024 0.1435
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0041 0.007 0.007
Trichomonas vaginalis rotamase, putative 0.0032 0.005 0.0504
Brugia malayi nuclear hormone receptor 0.0019 0.0024 0.0024
Trypanosoma brucei heat shock protein, putative 0.0095 0.0183 0.9221
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0024
Schistosoma mansoni heat shock protein 0.0039 0.0065 0.0065
Brugia malayi MH2 domain containing protein 0.0116 0.0229 0.0229
Brugia malayi hypothetical protein 0.0022 0.0029 0.0029
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0041 0.007 0.007
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0178 0.2944
Brugia malayi Hsp90 protein 0.0039 0.0065 0.0065
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0036 0.0257
Brugia malayi nuclear receptor RXR 0.0022 0.0029 0.0029
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0019 0.0024 0.1435
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0041 0.007 0.007
Leishmania major heat shock protein 83-1 0.0095 0.0183 0.9221
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0019 0.0024 0.0022
Schistosoma mansoni nuclear hormone receptor 0.0041 0.007 0.007
Onchocerca volvulus 0.0052 0.0094 0.3833
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0019 0.0024 0.0022
Schistosoma mansoni hypothetical protein 0.0043 0.0074 0.0074
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.0178 0.0178
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0029 0.0029
Trypanosoma cruzi Heat shock protein 83, putative 0.0095 0.0183 0.9221
Loa Loa (eye worm) hypothetical protein 0.0051 0.0092 0.0092
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0019 0.0024 0.1435
Echinococcus granulosus Protein patched homolog 1 0.0045 0.0078 0.0078
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0036 0.0257
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0178 0.2944
Leishmania major DNA topoisomerase ii 0.0019 0.0024 0.1023
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0046 0.0081 0.393
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.0178 0.0178
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0019 0.0024 0.0024
Plasmodium falciparum heat shock protein 90 0.0095 0.0183 0.9138
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0064 0.0064
Loa Loa (eye worm) intermediate filament protein 0.0052 0.0094 0.0094
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.0024 0.0024
Echinococcus granulosus endoplasmin 0.0075 0.0143 0.0143
Loa Loa (eye worm) transport to inner mitochondrial membrane family member 0.0046 0.0081 0.0081
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0104 0.0204 1
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0019 0.0024 0.0024
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0019 0.0024 0.0069
Schistosoma mansoni hypothetical protein 0.0047 0.0082 0.0082
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0059 0.0669
Mycobacterium ulcerans putative regultory protein 0.0019 0.0024 0.0022
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0064 0.0904
Brugia malayi CXXC zinc finger family protein 0.0028 0.0042 0.0042
Trypanosoma brucei heat shock protein, putative 0.0095 0.0183 0.9221
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0086 0.0086
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0059 0.0669
Echinococcus multilocularis cpg binding protein 0.0029 0.0045 0.0045
Schistosoma mansoni hypothetical protein 0.0031 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0041 0.007 0.007
Onchocerca volvulus 0.0028 0.0042 0.1554
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0036 0.0257
Brugia malayi hypothetical protein 0.0076 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0022 0.0029 0.0029
Echinococcus granulosus transcription factor btf3 0.0102 0.0199 0.0199
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0041 0.007 0.007
Brugia malayi hypothetical protein 0.0035 0.0057 0.0057
Brugia malayi glutaminase DH11.1 0.0266 0.0545 0.0545
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0119 0.0234 0.0234
Brugia malayi Niemann-Pick C1 protein precursor 0.0104 0.0204 0.0204
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.007 0.007
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0041 0.007 0.007
Echinococcus multilocularis expressed protein 0.0046 0.0081 0.0081
Brugia malayi hypothetical protein 0.0049 0.0087 0.0087
Schistosoma mansoni hypothetical protein 0.4743 1 1
Schistosoma mansoni tar DNA-binding protein 0.0123 0.0243 0.0243
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0019 0.0024 0.0022
Loa Loa (eye worm) hypothetical protein 0.0041 0.007 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.0199 0.3348
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0024 0.0024
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.0055 0.0055
Trypanosoma brucei heat shock protein, putative 0.0095 0.0183 0.9221
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0019 0.0024 0.0069
Loa Loa (eye worm) hypothetical protein 0.0025 0.0036 0.0036
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0019 0.0024 0.1023
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0029 0.0029
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0028 0.0043 0.0043
Onchocerca volvulus Bile acid receptor homolog 0.0041 0.007 0.2761
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0079 0.1062
Trichomonas vaginalis esterase, putative 0.0038 0.0064 0.0765
Echinococcus granulosus heat shock protein 90 0.0095 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.0023
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0059 0.2815
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.0178 0.0178
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0019 0.0024 0.0069
Schistosoma mansoni rotamase 0.0033 0.0052 0.0052
Trypanosoma cruzi transcription factor btf3, putative 0.0102 0.0199 1
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0075 0.0143 0.0143
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0036 0.0036
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0024 0.0024
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0024 0.0024
Leishmania major heat shock protein 83-1 0.0095 0.0183 0.9221
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.0199 0.3348
Plasmodium vivax basic transcription factor 3b, putative 0.0102 0.0199 1
Echinococcus multilocularis lamin 0.0052 0.0094 0.0094
Mycobacterium leprae Probable lipase LipE 0.0038 0.0064 0.336
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0024 0.0024
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.0178 0.0178
Echinococcus granulosus FTZ F1 alpha 0.0041 0.007 0.007
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0036 0.0257
Leishmania major heat shock protein 83-1 0.0095 0.0183 0.9221
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0041 0.007 0.007
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0019 0.0024 0.0069
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0039 0.0065 0.2299
Echinococcus multilocularis dnaJ subfamily B 0.0397 0.0821 0.0821
Schistosoma mansoni inositol monophosphatase 0.0036 0.0059 0.0059
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0046 0.0081 0.0081
Toxoplasma gondii DNA topoisomerase 2, putative 0.0019 0.0024 0.1023
Trypanosoma brucei heat shock protein, putative 0.0095 0.0183 0.9221
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0019 0.0024 0.1023
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0019 0.0024 0.0024
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0019 0.0024 0.1023
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.0024 0.0024
Brugia malayi steroid hormone receptor 0.0041 0.007 0.007
Echinococcus multilocularis endoplasmin 0.0075 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0041 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0024 0.0035 0.0035
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0052 0.0094 0.0094
Echinococcus multilocularis protein dispatched 1 0.0051 0.0091 0.0091
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.0024 0.0024
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0178 0.2944
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0079 0.1062
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0019 0.0024 0.1023
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.007 0.007
Schistosoma mansoni lamin 0.0052 0.0094 0.0094
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0036 0.0036
Echinococcus multilocularis heat shock protein 90 0.0075 0.0143 0.0143
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0064 0.0064
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0086 0.0086
Entamoeba histolytica heat shock protein 90, putative 0.0095 0.0183 0.8884
Schistosoma mansoni cpg binding protein 0.0029 0.0045 0.0045
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0059 0.1943
Mycobacterium tuberculosis Conserved protein 0.0038 0.0064 0.0904
Entamoeba histolytica hypothetical protein 0.0102 0.0199 0.9729
Loa Loa (eye worm) RNA binding protein 0.0123 0.0243 0.0243
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.0043 0.0074 0.0074
Echinococcus granulosus expressed protein 0.0033 0.0052 0.0052
Plasmodium vivax DNA topoisomerase II, putative 0.0019 0.0024 0.0065
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0036 0.1653
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0019 0.0024 0.0022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0041 0.007 0.007
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.007 0.007
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0019 0.0024 0.0024
Brugia malayi RNA binding protein 0.0123 0.0243 0.0243
Loa Loa (eye worm) hypothetical protein 0.0097 0.0188 0.0188
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0059 0.0689
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0029 0.0029
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0019 0.0024 0.0024
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0143 0.6851
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.0024 0.0024
Trypanosoma brucei DNA topoisomerase ii 0.0019 0.0024 0.1023
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.0023
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0244 0.0499 1
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0019 0.0024 0.076
Loa Loa (eye worm) hypothetical protein 0.0022 0.0029 0.0029
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0086 0.0086
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0025 0.0037 0.0037
Trypanosoma brucei heat shock protein 84, putative 0.0039 0.0065 0.3144
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0064 0.0765
Brugia malayi nuclear receptor NHR-67 0.0019 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.0023
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0041 0.007 0.007
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0052 0.0052
Onchocerca volvulus 0.0019 0.0024 0.0757
Trypanosoma cruzi heat shock protein 85, putative 0.0095 0.0183 0.9221
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0041 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0038 0.0064 0.0064
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0036 0.0683
Toxoplasma gondii NAC domain-containing protein 0.0102 0.0199 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0064 0.0064
Schistosoma mansoni tar DNA-binding protein 0.0123 0.0243 0.0243
Giardia lamblia Grp94/Hsp90 0.0075 0.0143 0.7443
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0024
Echinococcus multilocularis Niemann Pick C1 protein 0.0149 0.0298 0.0298
Echinococcus granulosus ecdysone induced protein 78C 0.0041 0.007 0.007
Trypanosoma cruzi heat shock protein 85, putative 0.0095 0.0183 0.9221
Echinococcus multilocularis expressed conserved protein 0.0098 0.019 0.019
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0048 0.0048
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0059 0.2815
Loa Loa (eye worm) hypothetical protein 0.0025 0.0037 0.0037
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0123 0.0243 0.0243
Echinococcus multilocularis expressed protein 0.0033 0.0052 0.0052
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0001 0.0001
Trypanosoma brucei developmentally regulated phosphoprotein 0.0019 0.0024 0.1023
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0057 0.0057
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0024 0.0024
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0064 0.0765
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0041 0.007 0.007
Leishmania major heat shock protein 83-1 0.0095 0.0183 0.9221
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.0199 0.3348
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.0178 0.8915
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0036 0.0257
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0048 0.0048
Echinococcus granulosus indoleamine 23 dioxygenase 2 0.4743 1 1
Echinococcus granulosus expressed protein 0.0046 0.0081 0.0081
Schistosoma mansoni pyruvate dehydrogenase 0.0019 0.0024 0.0024
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1698 0.357 0.357
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0075 0.0143 0.2553
Loa Loa (eye worm) hypothetical protein 0.0022 0.0029 0.0029
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0041 0.007 0.2761
Brugia malayi Inositol-1 0.0036 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0038 0.0064 0.0064
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0075 0.0143 1
Mycobacterium tuberculosis Conserved protein 0.0038 0.0064 0.0904
Loa Loa (eye worm) hypothetical protein 0.0022 0.0029 0.0029
Schistosoma mansoni zinc finger protein 0.0019 0.0024 0.0024
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0023 0.0045
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0024 0.0065
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0075 0.0143 0.7124
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0048 0.0048
Leishmania major basic transcription factor 3a, putative 0.0102 0.0199 1
Schistosoma mansoni transcription factor btf3 0.0102 0.0199 0.0199
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0178 0.8915
Brugia malayi tailless protein 0.0019 0.0024 0.0024
Schistosoma mansoni nuclear receptor 0.0019 0.0024 0.0024
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0029 0.0029
Schistosoma mansoni glutaminase 0.0266 0.0545 0.0545
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0024
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0178 0.2944
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0046 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0038 0.0064 0.0064
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.0024 0.0024
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0051 0.227
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0019 0.0024 0.1023
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0064 0.0904
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0045 0.0078 0.0078
Loa Loa (eye worm) indoleamine 2,3-dioxygenase 0.4743 1 1
Brugia malayi Endoplasmin precursor 0.0095 0.0183 0.0183
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0052 0.0052
Brugia malayi hypothetical protein 0.0019 0.0024 0.0024
Brugia malayi cytoplasmic intermediate filament protein 0.0028 0.0043 0.0043
Plasmodium falciparum DNA topoisomerase 2 0.0019 0.0024 0.0065
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0019 0.0024 0.0024
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.007 0.007
Giardia lamblia Kinase, PLK 0.0092 0.0178 0.9627
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0041 0.007 0.007
Leishmania major heat shock protein 83-1 0.0095 0.0183 0.9221
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0075 0.0143 1
Plasmodium vivax endoplasmin, putative 0.0095 0.0183 0.9138
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0041 0.007 0.007
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0019 0.0024 0.0022
Trypanosoma cruzi DNA topoisomerase II, putative 0.0019 0.0024 0.1023
Leishmania major heat shock protein 83-1 0.0095 0.0183 0.9221
Loa Loa (eye worm) hypothetical protein 0.0055 0.0099 0.0099
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0041 0.007 0.007
Trypanosoma cruzi heat shock protein 90, putative 0.0075 0.0143 0.7124
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0019 0.0024 0.0069
Echinococcus multilocularis lamin dm0 0.0052 0.0094 0.0094
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0046 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0024
Brugia malayi Mitochondrial import inner membrane translocase subunit TIM10 0.0046 0.0081 0.0081
Toxoplasma gondii heat shock protein 90, putative 0.0095 0.0183 0.9221
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0229 0.0229
Echinococcus multilocularis thyroid hormone receptor alpha 0.0041 0.007 0.007
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0052 0.0094 0.0094
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0064 0.2334
Echinococcus multilocularis heat shock protein 90 0.0095 0.0183 0.0183
Echinococcus multilocularis FTZ F1 alpha 0.0041 0.007 0.007
Echinococcus granulosus sterol regulatory element binding protein 0.0045 0.0078 0.0078
Trypanosoma brucei Heat shock protein 83, putative 0.0095 0.0183 0.9221
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0052 0.0535
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.0123 0.0123
Trichomonas vaginalis heat shock protein, putative 0.0095 0.0183 0.3058
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0143 0.7155
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0041 0.007 0.007
Loa Loa (eye worm) glutaminase 0.0266 0.0545 0.0545
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0039 0.0065 0.0065
Trypanosoma brucei heat shock protein, putative 0.0095 0.0183 0.9221
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0039 0.0065 0.0065
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0041 0.007 0.007
Echinococcus multilocularis heat shock protein 0.0095 0.0183 0.0183
Brugia malayi TAR-binding protein 0.0123 0.0243 0.0243
Schistosoma mansoni heat shock protein 0.0095 0.0183 0.0183
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0095 0.4655
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0025 0.0037 0.0037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0041 0.007 0.007
Onchocerca volvulus Huntingtin homolog 0.0119 0.0234 1
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0046 0.0081 0.1253
Onchocerca volvulus 0.0047 0.0082 0.3311
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.007 0.007
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0019 0.0024 0.1023
Trypanosoma brucei heat shock protein 90, putative 0.0095 0.0183 0.9221
Brugia malayi photoreceptor-specific nuclear receptor 0.0041 0.007 0.007
Onchocerca volvulus 0.0038 0.0064 0.2514
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0178 0.0178
Loa Loa (eye worm) hypothetical protein 0.0119 0.0234 0.0234
Leishmania major heat shock protein 83-1 0.0095 0.0183 0.9221
Echinococcus granulosus heat shock protein 0.0095 0.0183 0.0183
Brugia malayi hypothetical protein 0.0229 0.0468 0.0468
Schistosoma mansoni hypothetical protein 0.0397 0.0821 0.0821
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0024 0.0024
Trypanosoma brucei heat shock protein, putative 0.0095 0.0183 0.9221
Schistosoma mansoni hypothetical protein 0.0031 0.0048 0.0048
Treponema pallidum heat shock protein 90 0.0075 0.0143 1
Brugia malayi ecdysone receptor 0.0019 0.0024 0.0024
Schistosoma mansoni endoplasmin 0.0095 0.0183 0.0183
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.0188 0.0188
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0229 0.0229
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0086 0.0086
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0046 0.0081 0.3283
Loa Loa (eye worm) ICD-1 protein 0.0102 0.0199 0.0199
Toxoplasma gondii LsmAD domain-containing protein 0.0076 0.0143 0.7155
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0041 0.007 0.007
Echinococcus granulosus cpg binding protein 0.0029 0.0045 0.0045
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0064 0.3073
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0046 0.0081 0.393
Echinococcus granulosus heat shock protein 90 0.0075 0.0143 0.0143
Trichomonas vaginalis endoplasmin, putative 0.0058 0.0106 0.1573
Mycobacterium tuberculosis Probable two component sensor kinase 0.0019 0.0024 0.0069
Leishmania major heat shock protein 83-1 0.0095 0.0183 0.9221
Mycobacterium tuberculosis Possible two component sensor kinase 0.0019 0.0024 0.0069
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0041 0.007 0.007
Loa Loa (eye worm) isocitrate dehydrogenase 0.0046 0.0081 0.0081
Echinococcus granulosus dnaJ subfamily B 0.0397 0.0821 0.0821
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0029 0.0029
Schistosoma mansoni steroid hormone receptor ad4bp 0.0041 0.007 0.007
Schistosoma mansoni tar DNA-binding protein 0.0123 0.0243 0.0243
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0024
Schistosoma mansoni survival motor neuron protein 0.0047 0.0082 0.0082
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0019 0.0024 0.0069
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.0178 0.8553
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0048 0.0048
Schistosoma mansoni intermediate filament proteins 0.0052 0.0094 0.0094
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0036 0.0036
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0046 0.0081 0.393
Echinococcus multilocularis ecdysone induced protein 78C 0.0041 0.007 0.007
Schistosoma mansoni tar DNA-binding protein 0.0123 0.0243 0.0243
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0036 0.0257
Leishmania major hypothetical protein, conserved 0.0019 0.0024 0.1023
Loa Loa (eye worm) hypothetical protein 0.0045 0.0078 0.0078
Schistosoma mansoni thyroid hormone receptor 0.0041 0.007 0.007
Trypanosoma cruzi heat shock protein 90, putative 0.0095 0.0183 0.9221
Brugia malayi ecdysteroid receptor 0.0041 0.007 0.007
Schistosoma mansoni mitochondrial import inner membrane translocase subunit tim10 0.0046 0.0081 0.0081
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0064 0.0064
Trypanosoma brucei PAB1-binding protein , putative 0.0076 0.0143 0.7155
Toxoplasma gondii ABC1 family protein 0.0038 0.0064 0.3073
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0001 0.0001
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0059 0.0059
Brugia malayi Intermediate filament tail domain containing protein 0.0052 0.0094 0.0094
Trypanosoma cruzi heat shock protein 85, putative 0.0095 0.0183 0.9221
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0036 0.0683
Schistosoma mansoni hypothetical protein 0.4743 1 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0038 0.0064 0.0064
Mycobacterium ulcerans DNA gyrase subunit B 0.0019 0.0024 0.0022
Schistosoma mansoni nuclear receptor 0.0019 0.0024 0.0024
Brugia malayi beta-lactamase 0.0038 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0104 0.0204 0.0204
Mycobacterium ulcerans two component sensor kinase MprB 0.0019 0.0024 0.0022
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0064 0.0904
Brugia malayi beta-lactamase family protein 0.0038 0.0064 0.0064
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.0024 0.0024
Chlamydia trachomatis DNA gyrase subunit B 0.0019 0.0024 1
Chlamydia trachomatis DNA gyrase subunit B 0.0019 0.0024 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0064 0.0064
Trypanosoma cruzi transcription factor btf3, putative 0.0102 0.0199 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.0095 0.0183 1
Leishmania major heat shock protein 83-1 0.0095 0.0183 0.9221
Entamoeba histolytica heat shock protein 90, putative 0.0095 0.0183 0.8884
Leishmania major heat shock protein 83-1 0.0095 0.0183 0.9221
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0036 0.0683
Onchocerca volvulus 0.0025 0.0036 0.13
Mycobacterium ulcerans two component regulator - sensor kinase 0.0019 0.0024 0.0022
Schistosoma mansoni kinase 0.0047 0.0082 0.0082
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0106 0.0207 0.0207
Plasmodium vivax DNA gyrase subunit B, putative 0.0019 0.0024 0.0065
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0041 0.007 0.007
Schistosoma mansoni hypothetical protein 0.0035 0.0057 0.0057
Echinococcus multilocularis tar DNA binding protein 0.0123 0.0243 0.0243
Onchocerca volvulus 0.0038 0.0064 0.2514
Loa Loa (eye worm) beta-lactamase 0.0038 0.0064 0.0064
Trypanosoma cruzi DNA topoisomerase II, putative 0.0019 0.0024 0.1023
Loa Loa (eye worm) heat shock protein 75 0.0039 0.0065 0.0065
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0064 0.0765
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0064 0.0904
Schistosoma mansoni coup transcription factor 0.0041 0.007 0.007
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.007 0.007
Onchocerca volvulus 0.0019 0.0024 0.0757
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0019 0.0024 0.076
Plasmodium falciparum DNA gyrase subunit B 0.0019 0.0024 0.0065
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.0024 0.0024
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0019 0.0024 0.1023
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.0024 0.0024
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0041 0.007 0.007
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0019 0.0024 0.1023
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM10, putative 0.0046 0.0081 0.3309
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0019 0.0024 0.076
Leishmania major heat shock protein 83-1 0.0095 0.0183 0.9221
Leishmania major heat shock protein 83-1 0.0095 0.0183 0.9221
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0019 0.0024 0.0069
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0041 0.007 0.007
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0019 0.0024 0.1023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0041 0.007 0.007
Onchocerca volvulus 0.0038 0.0064 0.2514
Plasmodium vivax heat shock protein 90, putative 0.0039 0.0065 0.2413
Loa Loa (eye worm) hypothetical protein 0.0229 0.0468 0.0468
Leishmania major heat shock protein 83-1 0.0095 0.0183 0.9221
Loa Loa (eye worm) hypothetical protein 0.0025 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0041 0.007 0.007
Mycobacterium ulcerans glutaminase 0.0266 0.0545 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0029 0.0029
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0048 0.0048
Echinococcus granulosus Niemann Pick C1 protein 0.0104 0.0204 0.0204
Echinococcus multilocularis sterol regulatory element binding protein 0.0045 0.0078 0.0078
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0001 0.0001
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0059 0.0059
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0041 0.007 0.007
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0057 0.0057
Echinococcus multilocularis isocitrate dehydrogenase 0.0046 0.0081 0.0081
Trichomonas vaginalis glutaminase, putative 0.0266 0.0545 1
Brugia malayi beta-lactamase family protein 0.0038 0.0064 0.0064
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0046 0.0081 0.0081
Trichomonas vaginalis heat shock protein, putative 0.0058 0.0106 0.1573
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0078 0.1031
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0041 0.007 0.007
Entamoeba histolytica hypothetical protein 0.0035 0.0057 0.1833
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0036 0.1033
Schistosoma mansoni heat shock protein 0.0095 0.0183 0.0183
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0019 0.0024 0.0022
Echinococcus multilocularis indoleamine 2,3 dioxygenase 2 0.4743 1 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0064 0.0904
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0024
Entamoeba histolytica transcription factor BTF3, putative 0.0102 0.0199 0.9729

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 210 nM Inhibitory concentration against Human Leukocyte Elastase from human sputum ChEMBL. 9191969

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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