Detailed information for compound 176504

Basic information

Technical information
  • TDR Targets ID: 176504
  • Name: N-[[(5S)-3-[3-fluoro-4-[4-[(E)-3-(4-fluorophe nyl)prop-2-enoyl]piperazin-1-yl]phenyl]-2-oxo -1,3-oxazolidin-5-yl]methyl]ethanethioamide
  • MW: 500.561 | Formula: C25H26F2N4O3S
  • H donors: 0 H acceptors: 2 LogP: 3.39 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: Fc1ccc(cc1)/C=C/C(=O)N1CCN(CC1)c1ccc(cc1F)N1C[C@@H](OC1=O)C/N=C(\S)/C
  • InChi: 1S/C25H26F2N4O3S/c1-17(35)28-15-21-16-31(25(33)34-21)20-7-8-23(22(27)14-20)29-10-12-30(13-11-29)24(32)9-4-18-2-5-19(26)6-3-18/h2-9,14,21H,10-13,15-16H2,1H3,(H,28,35)/b9-4+/t21-/m0/s1
  • InChiKey: OLGRIDVKGIQIMR-ZSIUJALASA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[[(5S)-3-[3-fluoro-4-[4-[(E)-3-(4-fluorophenyl)prop-2-enoyl]piperazin-1-yl]phenyl]-2-oxo-oxazolidin-5-yl]methyl]thioacetamide
  • N-[[(5S)-3-[3-fluoro-4-[4-[(E)-3-(4-fluorophenyl)-1-oxoallyl]-1-piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]thioacetamide
  • N-[[(5S)-3-[3-fluoro-4-[4-[(E)-3-(4-fluorophenyl)acryloyl]piperazino]phenyl]-2-keto-oxazolidin-5-yl]methyl]thioacetamide
  • N-[[(5S)-3-[3-fluoro-4-[4-[(E)-3-(4-fluorophenyl)-1-oxoprop-2-enyl]-1-piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]thioacetamide
  • N-[[(5S)-3-[3-fluoro-4-[4-[(E)-3-(4-fluorophenyl)acryloyl]piperazin-1-yl]phenyl]-2-keto-oxazolidin-5-yl]methyl]thioacetamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis GPCR, family 2 0.0033 0.0146 0.0199
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0269 0.1374
Echinococcus granulosus calpain A 0.0016 0.0049 0.0067
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0172 0.0217
Mycobacterium ulcerans monoamine oxidase 0.0344 0.1945 0.1932
Echinococcus multilocularis cathepsin b 0.0134 0.0731 0.0995
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0172 0.0214
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0344 0.1945 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0172 0.0882
Schistosoma mansoni ap endonuclease 0.0037 0.0172 0.0233
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.001 0.0016 0.002
Plasmodium vivax SET domain protein, putative 0.003 0.0128 0.0658
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0344 0.1945 1
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0045 0.0214 0.0291
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.001 0.0016 0.002
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.001 0.0016 0.002
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0344 0.1945 0.1932
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0016 0.0049 0.0254
Echinococcus multilocularis calpain 5 0.0016 0.0049 0.0067
Trypanosoma cruzi UDP-galactopyranose mutase 0.0344 0.1945 1
Echinococcus granulosus cytochrome P450 2K1 0.001 0.0016 0.0022
Brugia malayi SWIRM domain containing protein 0.138 0.7923 1
Entamoeba histolytica calpain large subunit domain III containing protein 0.0011 0.0021 0.0404
Brugia malayi hypothetical protein 0.0344 0.1945 0.2455
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.001 0.0016 0.0084
Entamoeba histolytica hypothetical protein 0.0099 0.053 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0146 0.0199
Toxoplasma gondii SWIRM domain-containing protein 0.0099 0.053 0.2713
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0172 0.0882
Echinococcus multilocularis lysine specific histone demethylase 1A 0.128 0.7349 1
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.001 0.0016 0.002
Loa Loa (eye worm) calpain 0.0016 0.0049 0.0062
Onchocerca volvulus 0.0231 0.1292 0.1631
Mycobacterium tuberculosis Possible oxidoreductase 0.0344 0.1945 0.2428
Schistosoma mansoni ap endonuclease 0.0037 0.0172 0.0233
Trypanosoma cruzi UDP-galactopyranose mutase 0.0344 0.1945 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0492 0.067
Entamoeba histolytica SWIRM domain protein 0.0099 0.053 1
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0366 0.0461
Toxoplasma gondii histone lysine-specific demethylase 0.0344 0.1945 0.995
Leishmania major cytochrome p450-like protein 0.001 0.0016 0.0084
Schistosoma mansoni hypothetical protein 0.0071 0.0366 0.0497
Schistosoma mansoni hypothetical protein 0.0033 0.0146 0.0199
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0016 0.0049 0.0254
Echinococcus granulosus neuropeptide s receptor 0.0478 0.2719 0.37
Echinococcus granulosus calpain 0.0016 0.0049 0.0067
Trypanosoma cruzi kinesin, putative 0.0011 0.0021 0.011
Giardia lamblia Cathepsin B precursor 0.0044 0.0212 0.4
Echinococcus granulosus calpain A 0.0045 0.0214 0.0291
Echinococcus granulosus neuropeptide receptor A26 0.0478 0.2719 0.37
Loa Loa (eye worm) cytochrome P450 family protein 0.001 0.0016 0.0021
Trypanosoma brucei kinesin, putative 0.0011 0.0021 0.1011
Echinococcus multilocularis calpain 7 (C02 family) 0.0016 0.0049 0.0067
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.001 0.0016 0.002
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.001 0.0016 0.002
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0344 0.1945 1
Schistosoma mansoni calpain-7 (C02 family) 0.0016 0.0049 0.0067
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0044 0.0212 0.1091
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.001 0.0016 0.002
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0134 0.0731 0.0995
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0492 0.067
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.1395 0.8012 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0016 0.0049 0.0254
Schistosoma mansoni calpain (C02 family) 0.0016 0.0049 0.0067
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.001 0.0016 0.002
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0172 0.0882
Trypanosoma cruzi cytochrome P450, putative 0.001 0.0016 0.0084
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0172 0.0882
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.113 0.1427
Loa Loa (eye worm) cytochrome P450 family protein 0.001 0.0016 0.0021
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0016 0.0049 0.0254
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0305 0.0415
Schistosoma mansoni cytochrome P450 0.001 0.0016 0.0022
Onchocerca volvulus 0.0027 0.011 0.0138
Echinococcus multilocularis cathepsin b 0.0134 0.0731 0.0995
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.001 0.0016 0.002
Brugia malayi Cytochrome P450 family protein 0.001 0.0016 0.0021
Entamoeba histolytica protein kinase, putative 0.0011 0.0021 0.0404
Echinococcus multilocularis neuropeptide receptor A26 0.0478 0.2719 0.37
Toxoplasma gondii cathepsin B 0.0044 0.0212 0.1085
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0492 0.067
Chlamydia trachomatis protoporphyrinogen oxidase 0.0344 0.1945 0.5
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0045 0.0214 0.0291
Echinococcus multilocularis neuropeptide s receptor 0.0478 0.2719 0.37
Brugia malayi CXXC zinc finger family protein 0.0028 0.0118 0.0149
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0172 0.1328
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0134 0.0731 0.0995
Loa Loa (eye worm) hypothetical protein 0.0071 0.0366 0.0461
Trichomonas vaginalis conserved hypothetical protein 0.0099 0.053 0.4105
Schistosoma mansoni hypothetical protein 0.0523 0.2975 0.4048
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0146 0.0184
Loa Loa (eye worm) hypothetical protein 0.0027 0.011 0.0138
Brugia malayi Cytochrome P450 family protein 0.001 0.0016 0.0021
Loa Loa (eye worm) cytochrome P450 0.001 0.0016 0.0021
Schistosoma mansoni Mername-AA248 (C02 family) 0.0016 0.0049 0.0067
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0172 0.0882
Schistosoma mansoni hypothetical protein 0.0033 0.0146 0.0199
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.001 0.0016 0.002
Loa Loa (eye worm) hypothetical protein 0.0344 0.1945 0.2455
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.001 0.0016 0.002
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0118 0.0149
Schistosoma mansoni calpain-7 (C02 family) 0.0016 0.0049 0.0067
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.0231 0.0291
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0346 0.1955 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0172 0.0156
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0146 0.0199
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0104 0.0555 0.07
Schistosoma mansoni amine oxidase 0.0344 0.1945 0.2647
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0128 0.0174
Echinococcus granulosus cpg binding protein 0.003 0.0127 0.0173
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0043 0.0202 0.0275
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.001 0.0016 0.002
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0016 0.0049 0.0254
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0104 0.0555 0.07
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0492 0.067
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.001 0.0016 0.002
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0172 0.3236
Brugia malayi calpain family protein 1 0.0043 0.0202 0.0255
Echinococcus granulosus GPCR family 2 0.0033 0.0146 0.0199
Echinococcus multilocularis hypothetical protein 0.0016 0.0049 0.0067
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0146 0.0199
Loa Loa (eye worm) hypothetical protein 0.0444 0.2519 0.3179
Schistosoma mansoni amine oxidase 0.0344 0.1945 0.2647
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0013 0.0017
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0172 0.0233
Toxoplasma gondii cytochrome p450 superfamily protein 0.001 0.0016 0.0083
Brugia malayi Calcitonin receptor-like protein seb-1 0.0104 0.0555 0.07
Schistosoma mansoni hypothetical protein 0.0033 0.0146 0.0199
Trichomonas vaginalis set domain proteins, putative 0.0231 0.1292 1
Loa Loa (eye worm) cathepsin B 0.0044 0.0212 0.0268
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.001 0.0016 0.0084
Onchocerca volvulus 0.003 0.0128 0.0162
Echinococcus granulosus dnaJ subfamily B 0.0398 0.2256 0.307
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0172 0.8089
Giardia lamblia hypothetical protein 0.0099 0.053 1
Leishmania major cytochrome p450-like protein 0.001 0.0016 0.0084
Mycobacterium ulcerans oxidoreductase 0.0344 0.1945 0.1932
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0492 0.067
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0099 0.053 0.0722
Loa Loa (eye worm) hypothetical protein 0.0099 0.053 0.0669
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0172 0.3236
Loa Loa (eye worm) hypothetical protein 0.003 0.0128 0.0162
Brugia malayi calpain 5 0.0011 0.0021 0.0027
Echinococcus multilocularis cpg binding protein 0.003 0.0127 0.0173
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0003 0.0004
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0492 0.067
Echinococcus multilocularis calpain A 0.0045 0.0214 0.0291
Mycobacterium tuberculosis Conserved hypothetical protein 0.0344 0.1945 0.2428
Trypanosoma cruzi cytochrome p450-like protein, putative 0.001 0.0016 0.0084
Loa Loa (eye worm) hypothetical protein 0.0043 0.0202 0.0255
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0172 0.0233
Leishmania major lanosterol 14-alpha-demethylase, putative 0.001 0.0016 0.0084
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.001 0.0016 0.002
Loa Loa (eye worm) hypothetical protein 0.138 0.7923 1
Loa Loa (eye worm) calpain family protein 1 0.0031 0.0138 0.0174
Trypanosoma brucei calpain-like protein, putative 0.0016 0.0049 0.2325
Echinococcus multilocularis calpain 0.0016 0.0049 0.0067
Echinococcus multilocularis protoporphyrinogen oxidase 0.0344 0.1945 0.2647
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0003 0.0004
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0012 0.0015
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.001 0.0016 0.002
Schistosoma mansoni SWI/SNF complex-related 0.0099 0.053 0.0722
Trypanosoma brucei calpain-like protein, putative 0.0016 0.0049 0.2325
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0344 0.1945 1
Plasmodium vivax hypothetical protein, conserved 0.0344 0.1945 1
Schistosoma mansoni hypothetical protein 0.0523 0.2975 0.4048
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0016 0.0049 0.2325
Brugia malayi cathepsin B-like cysteine proteinase 0.0134 0.0731 0.0923
Leishmania major cytochrome p450-like protein 0.001 0.0016 0.0084
Plasmodium falciparum protoporphyrinogen oxidase 0.0344 0.1945 1
Trichomonas vaginalis conserved hypothetical protein 0.0099 0.053 0.4105
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.0492 0.0621
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0016 0.0049 0.0254
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0128 0.0174
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0134 0.0731 0.3758
Schistosoma mansoni calpain C (C02 family) 0.0016 0.0049 0.0067
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.001 0.0016 0.002
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0003 0.0004
Echinococcus granulosus calpain 7 C02 family 0.0016 0.0049 0.0067
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0128 0.0174
Echinococcus granulosus cathepsin b 0.0134 0.0731 0.0995
Trypanosoma brucei calpain-like protein, putative 0.0016 0.0049 0.2325
Loa Loa (eye worm) hypothetical protein 0.0038 0.0175 0.022
Brugia malayi Cytochrome P450 family protein 0.0048 0.0231 0.0291
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0146 0.0184
Trypanosoma brucei cysteine peptidase C (CPC) 0.0044 0.0212 1
Echinococcus granulosus geminin 0.0523 0.2975 0.4048
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0134 0.0731 0.0995
Loa Loa (eye worm) calpain 5 0.0011 0.0021 0.0027
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0128 0.0174
Trypanosoma cruzi kinesin, putative 0.0011 0.0021 0.011
Giardia lamblia Cathepsin B precursor 0.0044 0.0212 0.4
Loa Loa (eye worm) CYP4Cod1 0.001 0.0016 0.0021
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0016 0.0049 0.0254
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0172 0.1328
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0003 0.0004
Trypanosoma brucei cytochrome P450, putative 0.001 0.0016 0.0768
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0118 0.0161
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.001 0.0016 0.002
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0134 0.0731 0.0995
Trypanosoma brucei calpain-like protein, putative 0.0016 0.0049 0.2325
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0172 0.0217
Plasmodium vivax hypothetical protein, conserved 0.0344 0.1945 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0044 0.0212 0.1091
Schistosoma mansoni cpg binding protein 0.003 0.0127 0.0173
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0128 0.0174
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.001 0.0016 0.002
Schistosoma mansoni hypothetical protein 0.001 0.0016 0.0022
Loa Loa (eye worm) hypothetical protein 0.0134 0.0731 0.0923
Brugia malayi SWIRM domain containing protein 0.0099 0.053 0.0669
Echinococcus granulosus cathepsin b 0.0134 0.0731 0.0995
Echinococcus multilocularis 0.001 0.0016 0.0022
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0128 0.0655
Echinococcus granulosus calpain 5 0.0016 0.0049 0.0067
Loa Loa (eye worm) hypothetical protein 0.0031 0.0138 0.0174
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.001 0.0016 0.002
Loa Loa (eye worm) calpain family protein 1 0.0043 0.0202 0.0255
Plasmodium vivax calpain, putative 0.0016 0.0049 0.0254
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0016 0.0049 0.0254
Schistosoma mansoni hypothetical protein 0.0033 0.0146 0.0199
Brugia malayi amine oxidase, flavin-containing family protein 0.0444 0.2519 0.3179
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.001 0.0016 0.002
Brugia malayi Cytochrome P450 family protein 0.001 0.0016 0.0021
Loa Loa (eye worm) hypothetical protein 0.0033 0.0146 0.0184
Onchocerca volvulus 0.0028 0.0118 0.0149
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0044 0.0212 0.0289
Loa Loa (eye worm) histone methyltransferase 0.001 0.0013 0.0016
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0003 0.0004
Echinococcus granulosus lysine specific histone demethylase 1A 0.0344 0.1945 0.2647
Brugia malayi Pre-SET motif family protein 0.003 0.0128 0.0162
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0016 0.0049 0.0254
Brugia malayi calpain 7 0.0016 0.0049 0.0062
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0099 0.053 0.0722
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0344 0.1945 0.2647
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0045 0.0214 0.0291
Echinococcus granulosus lysine specific histone demethylase 1A 0.128 0.7349 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0044 0.0212 0.1642
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0016 0.0049 0.0254
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0344 0.1945 1
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0045 0.0214 0.0291
Trypanosoma brucei antigen, putative 0.0016 0.0049 0.2325
Schistosoma mansoni hypothetical protein 0.0398 0.2256 0.307
Trypanosoma cruzi cytochrome P450, putative 0.001 0.0016 0.0084
Loa Loa (eye worm) hypothetical protein 0.0344 0.1945 0.2455
Schistosoma mansoni cpg binding protein 0.003 0.0127 0.0173
Echinococcus multilocularis geminin 0.0523 0.2975 0.4048
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0013 0.0017
Giardia lamblia Cathepsin B precursor 0.0044 0.0212 0.4
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0146 0.0184
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0016 0.0049 0.0254
Schistosoma mansoni Lysine-specific histone demethylase 1 0.128 0.7349 1
Loa Loa (eye worm) hypothetical protein 0.128 0.7349 0.9276
Leishmania major kinesin, putative 0.0011 0.0021 0.011
Entamoeba histolytica SWIRM domain protein 0.0099 0.053 1
Loa Loa (eye worm) hypothetical protein 0.128 0.7349 0.9276
Leishmania major UDP-galactopyranose mutase 0.0344 0.1945 1
Brugia malayi calpain family protein 1 0.0043 0.0202 0.0255
Echinococcus multilocularis 0.0344 0.1945 0.2647
Echinococcus multilocularis calpain family protein 1, d 0.0031 0.0138 0.0187
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.001 0.0016 0.0768
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0016 0.0049 0.0254
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0172 0.5
Brugia malayi cytochrome P450 0.001 0.0016 0.0021
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0492 0.067
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.0492 0.0621
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0146 0.0199
Loa Loa (eye worm) hypothetical protein 0.0104 0.0555 0.07
Toxoplasma gondii exonuclease III APE 0.0037 0.0172 0.0878
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.174 1 1
Echinococcus multilocularis dnaJ subfamily B 0.0398 0.2256 0.307
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0128 0.0174
Onchocerca volvulus 0.138 0.7923 1
Schistosoma mansoni cpg binding protein 0.0028 0.0118 0.0161
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0128 0.0174
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0016 0.0049 0.0254
Brugia malayi Pre-SET motif family protein 0.0203 0.113 0.1427
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0016 0.0049 0.2325
Mycobacterium ulcerans dehydrogenase 0.0344 0.1945 0.1932
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0172 1

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 0.5 ug ml-1 Minimum inhibitory concentration against Bacillus pumilus MTCC 1607 ChEMBL. 15149661
MIC (functional) = 0.5 ug ml-1 Minimum inhibitory concentration against Bacillus cereus MTCC 430 ChEMBL. 15149661
MIC (functional) = 0.5 ug ml-1 Minimum inhibitory concentration against Staphylococcus epidermidis MTCC 155 ChEMBL. 15149661
MIC (functional) = 0.5 ug ml-1 Minimum inhibitory concentration against Enterococcus faecalis MTCC 439 ChEMBL. 15149661
MIC (functional) = 1 ug ml-1 Minimum inhibitory concentration of the compound against Staphylococcus aureus MTCC 96 ChEMBL. 15149661
MIC (functional) = 1 ug ml-1 Minimum inhibitory concentration of the compound against Staphylococcus aureus ATCC 14154 ChEMBL. 15149661
MIC (functional) = 2 ug ml-1 Minimum inhibitory concentration against Streptococcus pyogenes MTCC 442 ChEMBL. 15149661
MIC (functional) = 2 ug ml-1 Minimum inhibitory concentration of the compound against Enterococcus faecalis ATCC 14506 ChEMBL. 15149661
MIC (functional) = 4 ug ml-1 Minimum inhibitory concentration of the compound against Staphylococcus aureus ATCC 25923 ChEMBL. 15149661
MIC (functional) = 4 ug ml-1 Minimum inhibitory concentration of the compound against Staphylococcus aureus ATCC 29213 ChEMBL. 15149661
MIC (functional) > 16 ug ml-1 Minimum inhibitory concentration of the compound against Klebsiella pneumoniae ATCC 10031 ChEMBL. 15149661

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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