Detailed information for compound 1766275

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 439.433 | Formula: C19H19F2N3O5S
  • H donors: 3 H acceptors: 4 LogP: 2.74 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC[C@]1(C)NC(=O)c2c(NC1=O)ccc(c2)S(=O)(=O)Nc1ccc(cc1)OC(F)F
  • InChi: 1S/C19H19F2N3O5S/c1-3-19(2)17(26)22-15-9-8-13(10-14(15)16(25)23-19)30(27,28)24-11-4-6-12(7-5-11)29-18(20)21/h4-10,18,24H,3H2,1-2H3,(H,22,26)(H,23,25)/t19-/m0/s1
  • InChiKey: QBHUGPKPNMGAOH-IBGZPJMESA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens diacylglycerol O-acyltransferase 2 Starlite/ChEMBL References
Homo sapiens mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase Starlite/ChEMBL References
Homo sapiens mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase Starlite/ChEMBL References
Homo sapiens diacylglycerol O-acyltransferase 1 Starlite/ChEMBL References
Homo sapiens mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase Starlite/ChEMBL References
Mus musculus mannoside acetylglucosaminyltransferase 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) diacylglycerol acyltransferase Get druggable targets OG5_128200 All targets in OG5_128200
Trypanosoma brucei diacylglycerol acyltransferase, putative Get druggable targets OG5_127120 All targets in OG5_127120
Leishmania braziliensis diacylglycerol acyltransferase, putative Get druggable targets OG5_127120 All targets in OG5_127120
Plasmodium vivax diacylglycerol O-acyltransferase, putative Get druggable targets OG5_128200 All targets in OG5_128200
Schistosoma japonicum ko:K00736 alpha-1,6-mannosyl-glycoprotein [EC2.4.1.143], putative Get druggable targets OG5_133242 All targets in OG5_133242
Trypanosoma cruzi diacylglycerol acyltransferase, putative Get druggable targets OG5_127120 All targets in OG5_127120
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_130586 All targets in OG5_130586
Trypanosoma brucei gambiense diacylglycerol acyltransferase, putative Get druggable targets OG5_127120 All targets in OG5_127120
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_130586 All targets in OG5_130586
Schistosoma japonicum ko:K00635 diacylglycerol O-acyltransferase [EC2.3.1.20], putative Get druggable targets OG5_128200 All targets in OG5_128200
Neospora caninum diacylglycerol acyltransferase, putative Get druggable targets OG5_128200 All targets in OG5_128200
Cryptosporidium hominis acyl-CoA:diacylglycerol acyltransferase 1-related enzyme Get druggable targets OG5_128200 All targets in OG5_128200
Echinococcus multilocularis diacylglycerol O acyltransferase 1 Get druggable targets OG5_128200 All targets in OG5_128200
Candida albicans similar to diacylglycerol acyltransferase type 2B Get druggable targets OG5_127120 All targets in OG5_127120
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_130586 All targets in OG5_130586
Theileria parva diacylglycerol O-acyltransferase, putative Get druggable targets OG5_128200 All targets in OG5_128200
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131824 All targets in OG5_131824
Schistosoma japonicum 2-acylglycerol O-acyltransferase 1, putative Get druggable targets OG5_127120 All targets in OG5_127120
Neospora caninum Diacylglycerol acyl transferase, related Get druggable targets OG5_127120 All targets in OG5_127120
Brugia malayi UDP-GlcNAc:a-6-D-mannoside b1,2-N-acetylglucosaminyltransferase II Get druggable targets OG5_133242 All targets in OG5_133242
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_130586 All targets in OG5_130586
Leishmania donovani diacylglycerol acyltransferase, putative Get druggable targets OG5_127120 All targets in OG5_127120
Cryptosporidium parvum diacylglycerol acyltransferase 1 Get druggable targets OG5_128200 All targets in OG5_128200
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_130586 All targets in OG5_130586
Trypanosoma congolense diacylglycerol acyltransferase, putative Get druggable targets OG5_127120 All targets in OG5_127120
Schistosoma mansoni alpha-13-mannosyl-glycoprotein beta-1 2-n-acetylglucosaminyltransferase Get druggable targets OG5_131824 All targets in OG5_131824
Plasmodium falciparum diacylglycerol O-acyltransferase Get druggable targets OG5_128200 All targets in OG5_128200
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128200 All targets in OG5_128200
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133242 All targets in OG5_133242
Schistosoma japonicum Diacylglycerol O-acyltransferase 1, putative Get druggable targets OG5_128200 All targets in OG5_128200
Brugia malayi diacylglycerol acyltransferase Get druggable targets OG5_128200 All targets in OG5_128200
Echinococcus granulosus alpha 13 mannosyl glycoprotein Get druggable targets OG5_131824 All targets in OG5_131824
Neospora caninum sterol O-acyltransferase, putative Get druggable targets OG5_128200 All targets in OG5_128200
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_130586 All targets in OG5_130586
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131824 All targets in OG5_131824
Plasmodium yoelii acyl transferase-related Get druggable targets OG5_128200 All targets in OG5_128200
Candida albicans Acyl-CoA cholesterol acyltransferase Get druggable targets OG5_128200 All targets in OG5_128200
Schistosoma japonicum ko:K00726 alpha-1,3-mannosyl-glycoprotein [EC2.4.1.101], putative Get druggable targets OG5_131824 All targets in OG5_131824
Loa Loa (eye worm) diacylglycerol acyltransferase Get druggable targets OG5_127120 All targets in OG5_127120
Echinococcus granulosus alpha 16 mannosyl glycoprotein Get druggable targets OG5_133242 All targets in OG5_133242
Leishmania infantum diacylglycerol acyltransferase, putative Get druggable targets OG5_127120 All targets in OG5_127120
Schistosoma japonicum Diacylglycerol O-acyltransferase 1, putative Get druggable targets OG5_128200 All targets in OG5_128200
Trypanosoma cruzi diacylglycerol acyltransferase, putative Get druggable targets OG5_127120 All targets in OG5_127120
Echinococcus multilocularis alpha 1,3 mannosyl glycoprotein Get druggable targets OG5_131824 All targets in OG5_131824
Echinococcus multilocularis alpha 1,6 mannosyl glycoprotein Get druggable targets OG5_133242 All targets in OG5_133242
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_130586 All targets in OG5_130586
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_130586 All targets in OG5_130586
Toxoplasma gondii dgat2l1-prov protein Get druggable targets OG5_127120 All targets in OG5_127120
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme Get druggable targets OG5_128200 All targets in OG5_128200
Echinococcus granulosus diacylglycerol O acyltransferase 1 Get druggable targets OG5_128200 All targets in OG5_128200
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_130586 All targets in OG5_130586
Leishmania mexicana hypothetical protein, conserved Get druggable targets OG5_127120 All targets in OG5_127120
Candida albicans similar to diacylglycerol acyltransferase type 2B Get druggable targets OG5_127120 All targets in OG5_127120
Schistosoma japonicum 2-acylglycerol O-acyltransferase 2-A, putative Get druggable targets OG5_127120 All targets in OG5_127120
Onchocerca volvulus Get druggable targets OG5_127120 All targets in OG5_127120
Brugia malayi GNT-I family protein Get druggable targets OG5_131824 All targets in OG5_131824
Plasmodium knowlesi diacylglycerol O-acyltransferase, putative Get druggable targets OG5_128200 All targets in OG5_128200
Brugia malayi diacylglycerol acyltransferase family protein Get druggable targets OG5_127120 All targets in OG5_127120
Candida albicans Acyl-CoA cholesterol acyltransferase Get druggable targets OG5_128200 All targets in OG5_128200
Leishmania major diacylglycerol acyltransferase, putative Get druggable targets OG5_127120 All targets in OG5_127120
Schistosoma mansoni diacylglycerol O-acyltransferase 1 Get druggable targets OG5_127120 All targets in OG5_127120
Schistosoma mansoni diacylglycerol O-acyltransferase 1 Get druggable targets OG5_128200 All targets in OG5_128200
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_127120 All targets in OG5_127120
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha Get druggable targets OG5_128200 All targets in OG5_128200
Plasmodium berghei diacylglycerol O-acyltransferase, putative Get druggable targets OG5_128200 All targets in OG5_128200
Cryptosporidium parvum hypothetical protein with 4 transmembrane domains Get druggable targets OG5_127120 All targets in OG5_127120
Babesia bovis diacylglycerol acyltransferase, putative Get druggable targets OG5_128200 All targets in OG5_128200
Schistosoma mansoni beta-12-n-acetylglucosaminyltransferase II Get druggable targets OG5_133242 All targets in OG5_133242
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania major diacylglycerol acyltransferase, putative diacylglycerol O-acyltransferase 2 345 aa 326 aa 26.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus TRP transient receptor potential channel 0.0032 0.027 0.027
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0032 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0004
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0032 0.027 0.0265
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0032 0.027 0.027
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.027 0.0265
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0032 0.027 0.027
Echinococcus granulosus potassium voltage gated channel protein 0.0032 0.027 0.027
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0989 0.0985
Schistosoma mansoni lamin 0.0053 0.052 0.0515
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0032 0.027 0.0265
Schistosoma mansoni hypothetical protein 0.0011 0.0024 0.002
Schistosoma mansoni transient receptor potential channel 0.0032 0.027 0.0265
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0454 0.0454
Brugia malayi Glycosylation related protein 12, isoform 0.0044 0.0415 0.0411
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0032 0.027 0.0265
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0096 0.1016 1
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.027 0.0265
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0989 0.0989
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0153 0.1685 0.1685
Echinococcus multilocularis sodium channel protein 0.0495 0.5668 0.5668
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.027 0.0265
Schistosoma mansoni transient receptor potential channel 0.0032 0.027 0.0265
Schistosoma mansoni two-pore calcium channel 0.0032 0.027 0.0265
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0989 0.0989
Schistosoma mansoni hypothetical protein 0.0048 0.0454 0.0449
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0032 0.027 0.0265
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0032 0.027 0.0265
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0086 0.0903 0.8837
Echinococcus granulosus voltage gated hydrogen channel 1 0.0032 0.027 0.027
Echinococcus granulosus hyperpolarization activated cyclic 0.0032 0.027 0.027
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.0197 0.0193
Echinococcus multilocularis alpha 1,3 mannosyl glycoprotein 0.0131 0.1425 0.1425
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0989 0.0989
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0454 0.0454
Onchocerca volvulus 0.0029 0.0231 0.1718
Loa Loa (eye worm) hypothetical protein 0.0032 0.027 0.027
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.027 0.0265
Trypanosoma brucei diacylglycerol acyltransferase, putative 0.0098 0.1037 1
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0338 0.0338
Brugia malayi MH2 domain containing protein 0.0116 0.1249 0.1245
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0173 0.0169
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0049 0.0045
Echinococcus granulosus sodium leak channel non selective protein 0.0032 0.027 0.027
Echinococcus multilocularis low density lipoprotein receptor protein 0.0009 0.0004 0.0004
Schistosoma mansoni cpg binding protein 0.003 0.0251 0.0246
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0026 0.0197 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0013 0.0049 0.5
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0103 0.0556
Leishmania major glycerol uptake protein, putative 0.0026 0.0197 0.0263
Echinococcus granulosus two pore calcium channel protein 1 0.0032 0.027 0.027
Echinococcus granulosus transient receptor potential cation channel 0.0032 0.027 0.027
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0032 0.027 0.0265
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0103 0.0329
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.0197 0.0193
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.0989 0.0989
Schistosoma mansoni hypothetical protein 0.0513 0.5883 0.5881
Schistosoma mansoni vesicular amine transporter 0.0032 0.027 0.0265
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0173 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0103 0.0103
Echinococcus multilocularis calcium activated potassium channel 0.0032 0.027 0.027
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0026 0.0197 0.0197
Leishmania major glycerol uptake protein, putative 0.0026 0.0197 0.0263
Schistosoma mansoni sterol O-acyltransferase 1 0.0026 0.0197 0.0193
Onchocerca volvulus 0.002 0.0126 0.0923
Brugia malayi Thioredoxin reductase 0.0038 0.0338 0.0334
Echinococcus granulosus neuropeptide receptor A26 0.0465 0.532 0.532
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0092 0.0439
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0009 0.0004 0.0004
Echinococcus granulosus transient receptor potential cation channel 0.0032 0.027 0.027
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0153 0.1685 1
Brugia malayi hypothetical protein 0.0024 0.0182 0.0178
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0098 0.1037 0.1037
Toxoplasma gondii transporter, cation channel family protein 0.0032 0.027 0.1347
Brugia malayi intermediate filament protein 0.0053 0.052 0.0515
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0153 0.1685 0.1685
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0032 0.027 0.027
Echinococcus granulosus lamin 0.0053 0.052 0.052
Loa Loa (eye worm) hypothetical protein 0.0026 0.0197 0.0197
Schistosoma mansoni hypothetical protein 0.0103 0.11 0.1096
Loa Loa (eye worm) hypothetical protein 0.002 0.0126 0.0126
Echinococcus multilocularis potassium voltage gated channel protein 0.0032 0.027 0.027
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0092 0.0439
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0026 0.0197 0.0193
Echinococcus multilocularis potassium voltage gated channel protein 0.0032 0.027 0.027
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0032 0.027 0.027
Echinococcus multilocularis two pore calcium channel protein 1 0.0032 0.027 0.027
Echinococcus multilocularis alpha 1,6 mannosyl glycoprotein 0.0866 1 1
Echinococcus multilocularis voltage dependent calcium channel 0.0032 0.027 0.027
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0173 0.0169
Toxoplasma gondii diacylglycerol acyltransferase 0.0022 0.0149 0.061
Schistosoma mansoni hypothetical protein 0.0513 0.5883 0.5881
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0009 0.0004 0.0004
Toxoplasma gondii Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase 0.0044 0.0415 0.2234
Toxoplasma gondii hypothetical protein 0.0026 0.0197 0.0903
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1249 0.1249
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0032 0.027 0.027
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0454 0.0449
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.027 0.0265
Entamoeba histolytica hypothetical protein 0.0026 0.0197 1
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0197 0.1054
Trichomonas vaginalis conserved hypothetical protein 0.0133 0.1451 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0024 0.0173 0.0173
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0009 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0026 0.0197 0.0197
Loa Loa (eye worm) hypothetical protein 0.0123 0.1326 0.1326
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0231 0.0231
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0032 0.027 0.0265
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0009 0.0004 0.0004
Brugia malayi Calcitonin receptor-like protein seb-1 0.0151 0.1658 0.1654
Loa Loa (eye worm) hypothetical protein 0.0032 0.027 0.027
Trypanosoma brucei glycerol uptake protein, putative 0.0026 0.0197 0.1495
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0032 0.027 0.027
Entamoeba histolytica hypothetical protein, conserved 0.0026 0.0197 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0173 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0086 0.0903 0.8667
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0032 0.027 0.027
Echinococcus granulosus short transient receptor potential channel 6 0.0032 0.027 0.027
Leishmania major hypothetical protein, unknown function,protein, unknown function 0.0022 0.0149 0.0178
Loa Loa (eye worm) calcium channel 0.0032 0.027 0.027
Echinococcus multilocularis transient receptor potential cation channel 0.0032 0.027 0.027
Echinococcus multilocularis neuropeptide receptor A26 0.0465 0.532 0.532
Loa Loa (eye worm) doublecortin family protein 0.002 0.0126 0.0126
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0032 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0018 0.0103 0.0103
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0024 0.0024
Echinococcus granulosus transient receptor potential cation channel 0.0032 0.027 0.027
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0049 0.5
Schistosoma mansoni rab6-interacting 0.002 0.0126 0.0122
Echinococcus granulosus sterol O acyltransferase 1 0.0026 0.0197 0.0197
Toxoplasma gondii transporter, cation channel family protein 0.0032 0.027 0.1347
Onchocerca volvulus 0.0032 0.027 0.2007
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0096 0.1016 1
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0153 0.1685 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0173 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0103 0.0103
Echinococcus granulosus neuropeptide s receptor 0.0465 0.532 0.532
Loa Loa (eye worm) hypothetical protein 0.0131 0.1425 0.1425
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.027 0.0265
Echinococcus multilocularis lamin 0.0053 0.052 0.052
Schistosoma mansoni hypothetical protein 0.0409 0.467 0.4667
Schistosoma mansoni voltage-gated cation channel 0.0032 0.027 0.0265
Toxoplasma gondii mono- or diacylglycerol acyltransferase 0.0022 0.0149 0.061
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0032 0.027 0.027
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0032 0.027 0.0265
Echinococcus multilocularis transient receptor potential cation channel 0.0032 0.027 0.027
Brugia malayi CXXC zinc finger family protein 0.0029 0.0231 0.0227
Echinococcus granulosus GPCR family 2 0.0048 0.0454 0.0454
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0004
Echinococcus multilocularis musashi 0.0053 0.052 0.052
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0096 0.1016 1
Schistosoma mansoni diacylglycerol O-acyltransferase 0.0022 0.0149 0.0145
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0026 0.0197 1
Brugia malayi hypothetical protein 0.0123 0.1326 0.1322
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.023 0.0226
Loa Loa (eye worm) hypothetical protein 0.0866 1 1
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0032 0.027 0.2231
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0032 0.027 0.0265
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.0197 0.1495
Schistosoma mansoni voltage-gated ion channel 0.0032 0.027 0.0265
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0049 0.0045
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0032 0.027 0.027
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0032 0.027 0.0265
Loa Loa (eye worm) hypothetical protein 0.0032 0.027 0.027
Echinococcus multilocularis neuropeptide s receptor 0.0465 0.532 0.532
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0032 0.027 0.027
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0197 0.1054
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0032 0.027 0.027
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0126 0.0126
Mycobacterium ulcerans hypothetical protein 0.0022 0.0149 0.8069
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0151 0.1658 0.1658
Trichomonas vaginalis porcupine, putative 0.0026 0.0197 0.1054
Leishmania major hypothetical protein, unknown function 0.0032 0.027 0.0392
Loa Loa (eye worm) hypothetical protein 0.0131 0.1425 0.1425
Echinococcus granulosus low density lipoprotein receptor protein 0.0009 0.0004 0.0004
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0086 0.0903 0.8837
Loa Loa (eye worm) hypothetical protein 0.0052 0.0508 0.0508
Schistosoma mansoni lipoxygenase 0.0082 0.0859 0.0855
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0454 0.0454
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0103 1
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0098 0.1037 1
Leishmania major glycerol uptake protein, putative 0.0026 0.0197 0.0263
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0026 0.0197 0.0197
Loa Loa (eye worm) MBOAT family protein 0.0026 0.0197 0.0197
Loa Loa (eye worm) hypothetical protein 0.0032 0.027 0.027
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0049 0.0049
Echinococcus multilocularis voltage gated potassium channel 0.0032 0.027 0.027
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0092 0.0439
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0032 0.027 0.1347
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0103 0.0329
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0009 0.0004 0.0004
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0049 0.5
Echinococcus granulosus Low density lipoprotein receptor class A cysteine rich 0.0009 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0004
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.027 0.0265
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0032 0.027 0.0265
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.027 0.0265
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0032 0.027 0.0265
Leishmania major hypothetical protein, conserved 0.0026 0.0197 0.0263
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0026 0.0197 0.0197
Onchocerca volvulus 0.0026 0.0197 0.1458
Schistosoma mansoni hypothetical protein 0.002 0.0126 0.0122
Loa Loa (eye worm) hypothetical protein 0.0032 0.027 0.027
Toxoplasma gondii hypothetical protein 0.0032 0.027 0.1347
Loa Loa (eye worm) hypothetical protein 0.0032 0.027 0.027
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0009 0.0004 0.0004
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0032 0.027 0.027
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0173 0.128
Trypanosoma brucei trypanothione reductase 0.0038 0.0338 0.292
Brugia malayi Doublecortin family protein 0.002 0.0126 0.0122
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0153 0.1685 1
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0032 0.027 0.027
Schistosoma mansoni ryanodine receptor related 0.0032 0.027 0.0265
Echinococcus granulosus low density lipoprotein receptor ldl 0.0009 0.0004 0.0004
Echinococcus granulosus geminin 0.0513 0.5883 0.5883
Loa Loa (eye worm) hypothetical protein 0.0032 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0004
Echinococcus granulosus cpg binding protein 0.003 0.0251 0.0251
Loa Loa (eye worm) hypothetical protein 0.0128 0.1385 0.1385
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0989 0.0985
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0022 0.0149 0.101
Echinococcus granulosus potassium voltage gated channel protein 0.0032 0.027 0.027
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.0197 0.1495
Loa Loa (eye worm) MBOAT family protein 0.0026 0.0197 0.0197
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0004
Schistosoma mansoni beta-12-n-acetylglucosaminyltransferase II 0.0866 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.027 0.0265
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0197 0.0197
Brugia malayi hypothetical protein 0.0032 0.027 0.0265
Loa Loa (eye worm) hypothetical protein 0.0026 0.0197 0.0197
Brugia malayi ion channel NompC 0.0032 0.027 0.0265
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0022 0.0149 0.101
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0153 0.1685 0.1685
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0032 0.027 0.0265
Toxoplasma gondii hypothetical protein 0.0052 0.0503 0.2774
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.027 0.0265
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0032 0.027 0.027
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.0989 0.0985
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0607 0.0603
Echinococcus granulosus dnaJ subfamily B 0.0409 0.467 0.467
Echinococcus granulosus sodium channel protein 0.0495 0.5668 0.5668
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0086 0.0903 0.8837
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0173 1
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0032 0.027 0.027
Loa Loa (eye worm) intermediate filament protein 0.0053 0.052 0.052
Trichomonas vaginalis conserved hypothetical protein 0.0133 0.1451 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0338 0.2985
Leishmania major glycerol uptake protein, putative 0.0026 0.0197 0.0263
Loa Loa (eye worm) hypothetical protein 0.0032 0.027 0.027
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0032 0.027 0.0265
Trichomonas vaginalis conserved hypothetical protein 0.0133 0.1451 1
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0032 0.027 0.2231
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0032 0.027 0.0265
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0032 0.027 0.0265
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0048 0.0454 0.0454
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0004
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0454 0.0449
Brugia malayi cation channel family protein 0.0032 0.027 0.0265
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0092 0.0439
Schistosoma mansoni transient receptor potential channel 0.0032 0.027 0.0265
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0173 0.022
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0032 0.027 0.027
Loa Loa (eye worm) ion channel NompC 0.0032 0.027 0.027
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0098 0.1037 0.1033
Echinococcus granulosus hypothetical protein 0.0032 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0032 0.027 0.027
Echinococcus multilocularis two pore calcium channel protein 2 0.0032 0.027 0.027
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0032 0.027 0.0265
Mycobacterium tuberculosis Probable oxidoreductase 0.0096 0.1016 1
Echinococcus granulosus alpha 13 mannosyl glycoprotein 0.0131 0.1425 0.1425
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.027 0.0265
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.023 0.023
Schistosoma mansoni polycystin 1-related 0.002 0.0126 0.0122
Loa Loa (eye worm) hypothetical protein 0.0025 0.0186 0.0186
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0032 0.027 0.0265
Echinococcus multilocularis hyperpolarization activated cyclic 0.0032 0.027 0.027
Loa Loa (eye worm) hhat protein 0.0026 0.0197 0.0197
Brugia malayi MBOAT family protein 0.0026 0.0197 0.0193
Leishmania major diacylglycerol acyltransferase, putative 0.0022 0.0149 0.0178
Loa Loa (eye worm) hypothetical protein 0.0032 0.027 0.027
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0032 0.027 0.027
Echinococcus granulosus potassium voltage gated channel protein 0.0032 0.027 0.027
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0032 0.027 0.027
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.0197 0.1495
Echinococcus granulosus potassium large conductance calcium activated 0.0032 0.027 0.027
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0182 0.0811
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0032 0.027 0.0265
Brugia malayi MBOAT family protein 0.0026 0.0197 0.0193
Trichomonas vaginalis conserved hypothetical protein 0.0133 0.1451 1
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0009 0.0004 0.0004
Schistosoma mansoni intermediate filament proteins 0.0053 0.052 0.0515
Echinococcus multilocularis short transient receptor potential channel 6 0.0032 0.027 0.027
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0454 0.0454
Loa Loa (eye worm) hypothetical protein 0.0044 0.0415 0.0415
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.027 0.0265
Schistosoma mansoni diacylglycerol O-acyltransferase 0.0022 0.0149 0.0145
Schistosoma mansoni lipoxygenase 0.0118 0.1273 0.1269
Trichomonas vaginalis conserved hypothetical protein 0.0133 0.1451 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0454 0.0454
Treponema pallidum alginate O-acetylation protein (algI) 0.0026 0.0197 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0989 0.0985
Loa Loa (eye worm) hypothetical protein 0.0024 0.0182 0.0182
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0032 0.027 0.0265
Onchocerca volvulus Huntingtin homolog 0.0123 0.1326 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0032 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0004
Loa Loa (eye worm) voltage-gated potassium channel 0.0032 0.027 0.027
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0022 0.0149 0.101
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0086 0.0903 0.8837
Toxoplasma gondii hypothetical protein 0.0032 0.027 0.1347
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0032 0.027 0.027
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0032 0.027 0.2007
Loa Loa (eye worm) MBOAT family protein 0.0026 0.0197 0.0197
Trypanosoma brucei glycerol uptake protein, putative 0.0026 0.0197 0.1495
Schistosoma mansoni lamin 0.0053 0.052 0.0515
Schistosoma mansoni hypothetical protein 0.0026 0.0197 0.0193
Echinococcus multilocularis sterol O acyltransferase 1 0.0026 0.0197 0.0197
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.0197 0.0197
Echinococcus granulosus ryanodine receptor 44f 0.0032 0.027 0.027
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0032 0.027 0.027
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.0197 0.0197
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0151 0.1658 0.1654
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0004
Schistosoma mansoni zinc finger protein 0.0026 0.0197 0.0193
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0032 0.027 0.0265
Echinococcus multilocularis hyperpolarization activated cyclic 0.0032 0.027 0.027
Brugia malayi voltage-dependent calcium channel 0.0032 0.027 0.0265
Schistosoma mansoni hypothetical protein 0.0048 0.0454 0.0449
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0026 0.0197 0.0197
Echinococcus granulosus transient receptor potential cation channel 0.0032 0.027 0.027
Loa Loa (eye worm) hhat protein 0.0026 0.0197 0.0197
Loa Loa (eye worm) hypothetical protein 0.0032 0.027 0.027
Onchocerca volvulus 0.0053 0.052 0.3898
Echinococcus multilocularis sodium leak channel non selective protein 0.0032 0.027 0.027
Echinococcus multilocularis GPCR, family 2 0.0048 0.0454 0.0454
Echinococcus multilocularis transient receptor potential cation channel 0.0032 0.027 0.027
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0026 0.0197 0.0197
Echinococcus multilocularis potassium voltage gated channel protein 0.0032 0.027 0.027
Echinococcus granulosus transient receptor potential cation channel 0.0032 0.027 0.027
Echinococcus granulosus basement membrane specific heparan sulfate 0.0009 0.0004 0.0004
Loa Loa (eye worm) voltage-gated calcium channel 0.0032 0.027 0.027
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0173 1
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0032 0.027 0.027
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0032 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0151 0.1658 0.1658
Entamoeba histolytica vacuolar protein sorting 26 0.0026 0.0197 1
Echinococcus multilocularis ryanodine receptor 44f 0.0032 0.027 0.027
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0032 0.027 0.1572
Echinococcus multilocularis transient receptor potential cation channel 0.0032 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0032 0.027 0.027
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0026 0.0197 1
Mycobacterium ulcerans hypothetical protein 0.0024 0.0173 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.027 0.027
Leishmania major trypanothione reductase 0.0038 0.0338 0.0513
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0103 0.4346
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0004
Echinococcus granulosus intermediate filament protein 0.0053 0.052 0.052
Loa Loa (eye worm) hypothetical protein 0.0032 0.027 0.027
Echinococcus multilocularis dnaJ subfamily B 0.0409 0.467 0.467
Echinococcus granulosus shaker cognate 0.0032 0.027 0.027
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0032 0.027 0.0265
Loa Loa (eye worm) calcium binding EGF domain-containing protein 0.0009 0.0004 0.0004
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.027 0.0265
Trichomonas vaginalis conserved hypothetical protein 0.0133 0.1451 1
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0032 0.027 0.0265
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0026 0.0197 0.0197
Echinococcus granulosus transient receptor potential gamma protein 0.0032 0.027 0.027
Echinococcus granulosus two pore calcium channel protein 2 0.0032 0.027 0.027
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.027 0.0265
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0032 0.027 0.0265
Loa Loa (eye worm) hypothetical protein 0.0026 0.0197 0.0197
Loa Loa (eye worm) hypothetical protein 0.0018 0.0103 0.0103
Echinococcus multilocularis voltage dependent calcium channel 0.0032 0.027 0.027
Schistosoma mansoni transient receptor potential channel 4 0.0032 0.027 0.0265
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0032 0.027 0.027
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0026 0.0197 0.0197
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0197 0.0197
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0495 0.5668 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0344 0.0344
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0032 0.027 0.2231
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0032 0.027 0.2231
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0026 0.0197 0.0197
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.001 0.0009 0.0004
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.027 0.0265
Echinococcus multilocularis voltage gated potassium channel 0.0032 0.027 0.027
Onchocerca volvulus 0.0024 0.0173 0.1276
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0009 0.0004 0.0004
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0173 0.128
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.0197 0.0197
Schistosoma mansoni 60S ribosomal protein L21 0.0032 0.027 0.0265
Echinococcus granulosus voltage gated potassium channel 0.0032 0.027 0.027
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0118 0.1273 0.1273
Schistosoma mansoni alpha-13-mannosyl-glycoprotein beta-1 2-n-acetylglucosaminyltransferase 0.0131 0.1425 0.1421
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0182 0.0811
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0032 0.027 0.0265
Plasmodium falciparum thioredoxin reductase 0.0038 0.0338 0.1763
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0025 0.0186 0.0186
Echinococcus multilocularis shaker cognate 0.0032 0.027 0.027
Schistosoma mansoni calcium-activated potassium channel 0.0032 0.027 0.0265
Loa Loa (eye worm) hypothetical protein 0.0032 0.027 0.027
Toxoplasma gondii dgat2l1-prov protein 0.0098 0.1037 0.6039
Echinococcus multilocularis cpg binding protein 0.003 0.0251 0.0251
Schistosoma mansoni voltage-dependent calcium channel 0.0032 0.027 0.0265
Echinococcus multilocularis transient receptor potential cation channel 0.0032 0.027 0.027
Onchocerca volvulus 0.002 0.0126 0.0923
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.027 0.0265
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0989 0.0989
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0338 0.292
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0182 0.1343
Echinococcus granulosus low density lipoprotein receptor ldl 0.0009 0.0004 0.0004
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0173 0.0169
Onchocerca volvulus 0.0098 0.1037 0.7816
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0153 0.1685 1
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0032 0.027 0.0265
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0032 0.027 0.1572
Schistosoma mansoni rab6-interacting 0.002 0.0126 0.0122
Echinococcus granulosus voltage dependent calcium channel 0.0032 0.027 0.027
Plasmodium falciparum glutathione reductase 0.0038 0.0338 0.1763
Echinococcus multilocularis lamin dm0 0.0053 0.052 0.052
Schistosoma mansoni hypothetical protein 0.0048 0.0454 0.0449
Schistosoma mansoni cpg binding protein 0.0029 0.0231 0.0227
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0032 0.027 0.027
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1249 0.1249
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0118 0.1273 0.1273
Echinococcus granulosus calcium activated potassium channel 0.0032 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0103 0.11 0.11
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0004
Brugia malayi glutathione reductase 0.0038 0.0338 0.0334
Brugia malayi Hhat protein 0.0026 0.0197 0.0193
Brugia malayi hypothetical protein 0.0016 0.0081 0.0076
Loa Loa (eye worm) hypothetical protein 0.0032 0.027 0.027
Echinococcus multilocularis transfer RNA-Gly 0.0032 0.027 0.027
Brugia malayi cation channel family protein 0.0032 0.027 0.0265
Echinococcus multilocularis RUN 0.002 0.0126 0.0126
Brugia malayi diacylglycerol acyltransferase family protein 0.0098 0.1037 0.1033
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0024 0.0024
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0032 0.027 0.0265
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0032 0.027 0.1347
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0032 0.027 0.0265
Echinococcus multilocularis geminin 0.0513 0.5883 0.5883
Toxoplasma gondii transporter, cation channel family protein 0.0032 0.027 0.1347
Echinococcus granulosus 5'partial|Low density lipoprotein receptor class A cysteine rich 0.0009 0.0004 0.0004
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0009 0.0004 0.0004
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0009 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0845 0.5672
Echinococcus granulosus voltage gated potassium channel 0.0032 0.027 0.027
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0197 0.1054
Leishmania major diacylglycerol acyltransferase, putative 0.0098 0.1037 0.1759
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0495 0.5668 0.5668
Echinococcus granulosus hyperpolarization activated cyclic 0.0032 0.027 0.027
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.0197 0.0193
Schistosoma mansoni loxhd1 0.002 0.0126 0.0122
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0032 0.027 0.027
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0024 0.0173 0.0173
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0032 0.027 0.027
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0182 0.1343
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0173 0.022
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.0197 0.0197
Loa Loa (eye worm) hypothetical protein 0.0024 0.0173 0.0173
Trypanosoma cruzi GUP1, putative 0.0026 0.0197 0.1495
Loa Loa (eye worm) voltage-gated potassium channel 0.0032 0.027 0.027
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.052 0.0515
Brugia malayi Transient-receptor-potential like protein 0.0032 0.027 0.0265
Loa Loa (eye worm) hypothetical protein 0.0032 0.027 0.027
Echinococcus multilocularis transient receptor potential cation channel 0.0032 0.027 0.027
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0026 0.0197 0.0197
Mycobacterium tuberculosis Probable reductase 0.0086 0.0903 0.8837
Onchocerca volvulus 0.0053 0.052 0.3898
Brugia malayi MBOAT family protein 0.0026 0.0197 0.0193
Onchocerca volvulus 0.0011 0.0023 0.0138
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0126 0.0471
Echinococcus granulosus basement membrane specific heparan sulfate 0.0009 0.0004 0.0004
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0182 0.1343
Trypanosoma brucei diacylglycerol acyltransferase, putative 0.0022 0.0149 0.101
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0009 0.0004 0.0004
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0032 0.027 0.0265
Trichomonas vaginalis conserved hypothetical protein 0.0133 0.1451 1
Echinococcus granulosus alpha 16 mannosyl glycoprotein 0.0866 1 1
Loa Loa (eye worm) voltage-dependent calcium channel 0.0032 0.027 0.027
Brugia malayi latrophilin 2 splice variant baaae 0.0103 0.11 0.1096
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.027 0.0265
Onchocerca volvulus Huntingtin homolog 0.0123 0.1326 1
Trichomonas vaginalis conserved hypothetical protein 0.0133 0.1451 1
Echinococcus multilocularis conserved hypothetical protein 0.0032 0.027 0.027
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0032 0.027 0.027
Echinococcus multilocularis transient receptor potential gamma protein 0.0032 0.027 0.027
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0032 0.027 0.2007
Echinococcus granulosus lamin dm0 0.0053 0.052 0.052
Loa Loa (eye worm) hypothetical protein 0.0032 0.027 0.027
Echinococcus multilocularis short transient receptor potential channel 6 0.0032 0.027 0.027
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0032 0.027 0.0265
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0022 0.0149 0.101
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0126 0.0126
Brugia malayi hypothetical protein 0.002 0.0126 0.0122
Plasmodium vivax glutathione reductase, putative 0.0038 0.0338 0.1763
Schistosoma mansoni hypothetical protein 0.0032 0.027 0.0265
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0182 0.0811
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0032 0.027 0.0265
Brugia malayi GNT-I family protein 0.0131 0.1425 0.1421
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.027 0.0265
Mycobacterium tuberculosis Probable dehydrogenase 0.0086 0.0903 0.8837
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0032 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0004
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.0197 0.0197
Echinococcus multilocularis potassium voltage gated channel protein 0.0032 0.027 0.027
Schistosoma mansoni hypothetical protein 0.0048 0.0454 0.0449
Trichomonas vaginalis transmembrane protein nessy, putative 0.0026 0.0197 0.1054
Loa Loa (eye worm) glutathione reductase 0.0038 0.0338 0.0338
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.001 0.0009 0.0004
Loa Loa (eye worm) hypothetical protein 0.0123 0.1326 0.1326
Loa Loa (eye worm) ryanodine receptor 0.0032 0.027 0.027
Echinococcus multilocularis potassium large conductance calcium activated 0.0032 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0032 0.027 0.027
Leishmania major hypothetical protein, conserved 0.0032 0.027 0.0392
Echinococcus granulosus RUN 0.002 0.0126 0.0126
Toxoplasma gondii thioredoxin reductase 0.0038 0.0338 0.1763
Brugia malayi Cyclic-nucleotide gated cation channel 0.0032 0.027 0.0265
Loa Loa (eye worm) hypothetical protein 0.0053 0.052 0.052
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0126 0.0126
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0338 0.1763
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0032 0.027 0.0265
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.0197 0.0197
Trypanosoma cruzi GUP1, putative 0.0026 0.0197 0.1495
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0126 0.0471
Loa Loa (eye worm) hypothetical protein 0.0032 0.027 0.027
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0173 1
Echinococcus granulosus potassium voltage gated channel protein 0.0032 0.027 0.027
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.052 0.052
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0004
Brugia malayi MBOAT family protein 0.0026 0.0197 0.0193
Brugia malayi hypothetical protein 0.002 0.0126 0.0122
Brugia malayi diacylglycerol acyltransferase 0.0153 0.1685 0.1682
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0182 0.0811
Loa Loa (eye worm) hypothetical protein 0.0026 0.0197 0.0197
Leishmania major glycerol uptake protein, putative 0.0026 0.0197 0.0263
Echinococcus granulosus voltage dependent calcium channel 0.0032 0.027 0.027
Echinococcus granulosus transient receptor potential cation channel 0.0032 0.027 0.027
Echinococcus granulosus potassium voltage gated channel protein 0.0032 0.027 0.027
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0026 0.0197 0.0193
Leishmania major diacylglycerol acyltransferase, putative 0.0022 0.0149 0.0178
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0032 0.027 0.027
Schistosoma mansoni hypothetical protein 0.0022 0.0149 0.0145
Leishmania major hypothetical protein, conserved 0.0024 0.0182 0.0236
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0004
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0032 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0018 0.0103 0.0103
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0173 1
Brugia malayi olfactory channel protein osm-9 0.0032 0.027 0.0265
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0153 0.1685 0.1682
Schistosoma mansoni cpg binding protein 0.003 0.0251 0.0246
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0032 0.027 0.027
Brugia malayi MBOAT family protein 0.0026 0.0197 0.0193
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0032 0.027 0.027
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0032 0.027 0.027
Echinococcus granulosus short transient receptor potential channel 6 0.0032 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0032 0.027 0.027
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0531 0.2946
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0032 0.027 0.027
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0098 0.1037 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0344 0.0344
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0173 0.022

Activities

Activity type Activity value Assay description Source Reference
Drug metabolism (ADMET) = 100 % Drug metabolism assessed as recombinant CYP3A4 (unknown origin)-mediated metabolite formation at 1 uM after 30 mins by LCMS analysis ChEMBL. 23541669
IC50 (binding) > 4 Inhibition of human recombinant AWAT2 expressed in insect cell membrane using cetyl alcohol and [14C]oleoyl coenzyme A as substrate after 10 to 15 mins by liquid scintillation counting ChEMBL. 23541669
IC50 (binding) > 4 Inhibition of human recombinant AWAT1 expressed in insect cell membrane using palmitoleyl alcohol and [14C]stearoyl coenzyme A as substrate after 10 to 15 mins by liquid scintillation counting ChEMBL. 23541669
IC50 (binding) > 5 Inhibition of human recombinant DGAT2 using dioleoyl-sn-glycerol and [14C]oleoyl coenzyme A as substrate after 30 mins by liquid scintillation counting ChEMBL. 23541669
IC50 (binding) > 5 Inhibition of human recombinant DGAT1 expressed in Sf9 cells using dioleoyl-sn-glycerol and [14C]oleoyl coenzyme A as substrate after 30 mins by liquid scintillation counting ChEMBL. 23541669
IC50 (binding) = 6.9 Inhibition of human recombinant MGAT3 expressed in insect cell membrane using 2-oleyl-sn-glycerol and [14C]-oleyl-coenzyme A as substrate after 10 to 15 mins by liquid scintillation counting analysis ChEMBL. 23541669
IC50 (binding) = 7.2 Inhibition of human recombinant MGAT1 expressed in insect cell membrane using 2-oleyl-sn-glycerol and [14C]-oleyl-coenzyme A as substrate after 10 to 15 mins by liquid scintillation counting analysis ChEMBL. 23541669
IC50 (binding) = 7.6 Inhibition of human recombinant MGAT2 expressed in insect cell membrane using 2-oleoyl-sn-glycerol and oleoyl coenzyme A as substrate after 40 mins by Ellmans assay based rapidfire LCMS analysis ChEMBL. 23541669
IC50 (binding) = 8.2 Inhibition of mouse recombinant MGAT2 expressed in insect cell membrane using 2-oleoyl-sn-glycerol and oleoyl coenzyme A as substrate after 40 mins by Ellmans assay based rapidfire LCMS analysis ChEMBL. 23541669
Papp (ADMET) = 1.1 ucm/s Apparent permeability from apical side to basolateral side of human Caco2 cells at 10 umol/l measured up to 120 mins by LCMS analysis ChEMBL. 23541669

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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