Detailed information for compound 1771446

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 303.354 | Formula: C20H17NO2
  • H donors: 1 H acceptors: 1 LogP: 4.23 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(N)ccc1C(=O)/C=C/c1ccc2c(c1)cccc2
  • InChi: 1S/C20H17NO2/c1-23-20-13-17(21)9-10-18(20)19(22)11-7-14-6-8-15-4-2-3-5-16(15)12-14/h2-13H,21H2,1H3/b11-7+
  • InChiKey: YBRCSFGCQAPBST-YRNVUSSQSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.1642 1
Brugia malayi protein-tyrosine kinase 0.0037 0.0904 0.1689
Schistosoma mansoni protein kinase 0.0015 0.0122 0.0184
Echinococcus granulosus tyrosine protein kinase HCK 0.0031 0.0677 0.0991
Trypanosoma brucei tubulin gamma chain 0.0088 0.2653 0.2563
Echinococcus multilocularis beta tubulin 0.0076 0.2253 0.3296
Leishmania major beta tubulin 0.0076 0.2253 0.2228
Loa Loa (eye worm) tubulin beta-2A chain 0.0076 0.2253 0.3275
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0031 0.0701 0.2371
Trypanosoma brucei beta tubulin 0.0076 0.2253 0.2158
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.1642 1
Echinococcus multilocularis roundabout 2 0.0014 0.0102 0.0149
Echinococcus granulosus Tubulin beta 2C chain 0.0076 0.2253 0.3296
Echinococcus granulosus single minded 2 0.0035 0.0815 0.1192
Onchocerca volvulus Tyrosine kinase homolog 0.0138 0.4403 1
Trichomonas vaginalis tubulin beta-1 chain, putative 0.003 0.0656 0.2213
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.1642 0.557
Brugia malayi Cell division protein ftsZ 0.003 0.0656 0.1194
Trichomonas vaginalis tubulin, putative 0.0031 0.0701 0.2371
Brugia malayi Cytochrome P450 family protein 0.0025 0.0485 0.0853
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0044 0.1126 0.1647
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.0041 0.1042 0.3372
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0041 0.1042 0.1013
Trichomonas vaginalis tubulin gamma chain, putative 0.0076 0.2253 0.7877
Leishmania major beta tubulin 0.0076 0.2253 0.2228
Brugia malayi Tubulin beta chain 0.003 0.0656 0.1194
Echinococcus multilocularis tubulin alpha 3 chain 0.0094 0.2852 0.4172
Loa Loa (eye worm) hypothetical protein 0.0015 0.0122 0.0146
Trypanosoma brucei alpha tubulin 0.0094 0.2852 0.2764
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) 0.0041 0.1042 1
Brugia malayi Tubulin alpha-2 chain 0.0094 0.2852 0.557
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0015 0.0122 0.0129
Trypanosoma brucei beta tubulin 0.0076 0.2253 0.2158
Leishmania major beta tubulin 0.0076 0.2253 0.2228
Schistosoma mansoni hypothetical protein 0.0066 0.1895 0.2866
Schistosoma mansoni intermediate filament proteins 0.0026 0.0512 0.0775
Echinococcus granulosus lamin dm0 0.0026 0.0512 0.0749
Brugia malayi hypothetical protein 0.0064 0.1817 0.3508
Echinococcus multilocularis tubulin alpha 1C chain 0.0094 0.2852 0.4172
Echinococcus granulosus tubulin alpha 1C chain 0.0094 0.2852 0.4172
Plasmodium falciparum alpha tubulin 1 0.0094 0.2852 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0031 0.0701 0.2371
Schistosoma mansoni hypothetical protein 0.0164 0.5284 0.7995
Echinococcus multilocularis tubulin alpha chain 0.0094 0.2852 0.4172
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0847 0.124
Mycobacterium ulcerans methionine aminopeptidase 0.0041 0.1042 0.3916
Loa Loa (eye worm) tubulin alpha 2 0.0063 0.1805 0.2616
Trypanosoma cruzi tubulin delta chain 0.003 0.0656 0.0626
Echinococcus multilocularis tubulin alpha chain 0.0094 0.2852 0.4172
Mycobacterium leprae cell division protein FtsZ 0.003 0.0656 0.6177
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0847 0.2658
Echinococcus granulosus tyrosine protein kinase Src64B 0.0044 0.1126 0.1647
Leishmania major alpha tubulin 0.0094 0.2852 0.2829
Leishmania major protein kinase, putative 0.0015 0.0122 0.009
Brugia malayi Tyrosine-protein kinase abl-1 0.0123 0.3876 0.761
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0012 0.0032 0.0047
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0041 0.1042 0.1577
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0044 0.1126 0.1647
Echinococcus granulosus beta tubulin 0.0076 0.2253 0.3296
Echinococcus multilocularis tubulin subunit TubB 0.0094 0.2852 0.4172
Echinococcus granulosus geminin 0.0164 0.5284 0.773
Loa Loa (eye worm) TK/ABL protein kinase 0.0208 0.6836 1
Echinococcus multilocularis tyrosine protein kinase Srms 0.0037 0.0904 0.1323
Echinococcus granulosus tubulin beta 4A class IVa 0.0076 0.2253 0.3296
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0015 0.0122 0.0178
Echinococcus granulosus lamin 0.0026 0.0512 0.0749
Onchocerca volvulus 0.0035 0.0815 0.179
Loa Loa (eye worm) tubulin alpha 2 0.0063 0.1805 0.2616
Schistosoma mansoni tyrosine kinase 0.0016 0.0149 0.0225
Toxoplasma gondii methionine aminopeptidase 0.0041 0.1042 0.3372
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0847 0.124
Brugia malayi Tubulin beta chain 0.0031 0.0701 0.1283
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0208 0.6836 1
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0847 0.1282
Onchocerca volvulus Huntingtin homolog 0.0118 0.3712 0.8419
Echinococcus multilocularis tubulin alpha 0.0062 0.1748 0.2557
Trichomonas vaginalis tubulin beta chain, putative 0.0094 0.2852 1
Schistosoma mansoni tyrosine kinase 0.0202 0.6609 1
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0076 0.2253 0.3296
Toxoplasma gondii methionine aminopeptidase 0.0041 0.1042 0.3372
Trichomonas vaginalis tubulin, putative 0.0031 0.0701 0.2371
Loa Loa (eye worm) tubulin gamma chain 0.0088 0.2653 0.3861
Echinococcus granulosus tyrosine kinase 0.0037 0.0904 0.1323
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0016 0.0149 0.0225
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0847 0.0818
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.0043 0.001
Echinococcus granulosus tubulin alpha chain 0.0094 0.2852 0.4172
Leishmania major alpha tubulin 0.0094 0.2852 0.2829
Loa Loa (eye worm) hypothetical protein 0.0013 0.0045 0.0033
Brugia malayi intermediate filament protein 0.0026 0.0512 0.0907
Schistosoma mansoni tubulin subunit beta 0.0076 0.2253 0.3409
Echinococcus granulosus tubulin alpha 0.0062 0.1748 0.2557
Echinococcus multilocularis jun protein 0.0081 0.2421 0.3542
Leishmania major alpha tubulin 0.0094 0.2852 0.2829
Echinococcus granulosus tyrosine protein kinase Fyn 0.0044 0.1126 0.1647
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0016 0.0149 0.0218
Trypanosoma brucei zeta tubulin 0.03 1 1
Loa Loa (eye worm) hypothetical protein 0.0118 0.3712 0.5415
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0043 0.001
Loa Loa (eye worm) BEN-1 protein 0.0076 0.2253 0.3275
Loa Loa (eye worm) tubulin alpha chain 0.0094 0.2852 0.4153
Loa Loa (eye worm) hypothetical protein 0.0079 0.2342 0.3405
Echinococcus multilocularis lamin 0.0026 0.0512 0.0749
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0041 0.1042 0.1525
Loa Loa (eye worm) hypothetical protein 0.0014 0.0102 0.0117
Loa Loa (eye worm) tubulin beta chain 0.0076 0.2253 0.3275
Echinococcus multilocularis Tubulin beta 2C chain 0.0076 0.2253 0.3296
Entamoeba histolytica protein kinase, putative 0.0031 0.0677 0.2036
Schistosoma mansoni tubulin subunit beta 0.0076 0.2253 0.3409
Echinococcus granulosus tyrosine protein kinase ABL1 0.0208 0.6836 1
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0815 0.1607
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0815 0.151
Trichomonas vaginalis tubulin epsilon chain, putative 0.0094 0.2852 1
Giardia lamblia Beta tubulin 0.0076 0.2253 0.7273
Giardia lamblia Alpha-tubulin 0.0094 0.2852 1
Schistosoma mansoni protein kinase 0.0015 0.0122 0.0184
Leishmania major beta tubulin 0.0076 0.2253 0.2228
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0041 0.1042 0.1525
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) 0.0041 0.1042 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0044 0.1126 0.1647
Schistosoma mansoni nck2/grb4 0.0013 0.0057 0.0086
Echinococcus granulosus Tubulin beta 2C chain 0.0076 0.2253 0.3296
Echinococcus granulosus tubulin subunit beta 0.0076 0.2253 0.3296
Trypanosoma cruzi zeta tubulin, putative 0.03 1 1
Loa Loa (eye worm) beta-tubulin 0.0076 0.2253 0.3275
Leishmania major beta tubulin 0.0076 0.2253 0.2228
Schistosoma mansoni growth factor receptor-bound protein 0.0013 0.0057 0.0086
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0013 0.0057 0.0051
Plasmodium falciparum tubulin epsilon chain, putative 0.0062 0.1748 0.5957
Trypanosoma cruzi alpha tubulin, putative 0.0094 0.2852 0.2829
Schistosoma mansoni tubulin subunit alpha 0.003 0.0656 0.0993
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0044 0.1126 0.1647
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.0041 0.1042 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0044 0.1126 0.1647
Echinococcus granulosus tubulin alpha chain 0.0094 0.2852 0.4172
Loa Loa (eye worm) tubulin beta chain 0.003 0.0656 0.0931
Trichomonas vaginalis tubulin beta chain, putative 0.0094 0.2852 1
Loa Loa (eye worm) SRC-1 0.0044 0.1126 0.162
Brugia malayi tubulin alpha-2 chain 0.0094 0.2852 0.557
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.0041 0.1042 0.1525
Brugia malayi tubulin alpha chain - mouse 0.0094 0.2852 0.557
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0063 0.1805 0.2616
Loa Loa (eye worm) hypothetical protein 0.0158 0.5075 0.7415
Loa Loa (eye worm) alpha-tubulin 0.0094 0.2852 0.4153
Plasmodium vivax tubulin beta chain, putative 0.0076 0.2253 0.7807
Leishmania major beta tubulin 0.0076 0.2253 0.2228
Loa Loa (eye worm) tubulin beta-4 chain 0.0076 0.2253 0.3275
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0013 0.0057 0.0086
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0485 0.0679
Echinococcus granulosus tubulin alpha 3 chain 0.0094 0.2852 0.4172
Leishmania major alpha tubulin 0.0094 0.2852 0.2829
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.0041 0.1042 0.3372
Schistosoma mansoni alpha tubulin 0.0094 0.2852 0.4315
Echinococcus multilocularis Tubulin beta 2C chain 0.0076 0.2253 0.3296
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.1642 0.1615
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.0041 0.1042 0.3916
Echinococcus granulosus NCK adaptor protein 0.0013 0.0057 0.0083
Schistosoma mansoni tubulin subunit beta 0.0076 0.2253 0.3409
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0656 0.2213
Toxoplasma gondii beta-tubulin, putative 0.0076 0.2253 0.7807
Echinococcus multilocularis NCK adaptor protein 0.0013 0.0057 0.0083
Entamoeba histolytica tubulin alpha chain, putative 0.0094 0.2852 1
Brugia malayi Tubulin alpha chain 0.003 0.0656 0.1194
Schistosoma mansoni tubulin subunit beta 0.0076 0.2253 0.3409
Trypanosoma brucei alpha tubulin 0.0094 0.2852 0.2764
Echinococcus granulosus tubulin gamma 1 chain 0.0088 0.2653 0.3881
Brugia malayi hypothetical protein 0.0158 0.5075 1
Echinococcus multilocularis beta tubulin 0.0076 0.2253 0.3296
Plasmodium vivax tubulin gamma chain, putative 0.0088 0.2653 0.9271
Trichomonas vaginalis tubulin alpha chain, putative 0.0062 0.1748 0.6085
Leishmania major beta tubulin 0.0076 0.2253 0.2228
Trypanosoma cruzi epsilon tubulin, putative 0.0062 0.1748 0.1721
Echinococcus multilocularis tyrosine protein kinase Blk 0.0037 0.0904 0.1323
Echinococcus multilocularis tyrosine protein kinase Abl 0.0092 0.2791 0.4082
Echinococcus granulosus twitchin 0.0012 0.001 0.0015
Echinococcus granulosus calcium dependent protein kinase 0.0015 0.0112 0.0163
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0041 0.1042 0.1577
Echinococcus granulosus tubulin subunit TubB 0.0094 0.2852 0.4172
Chlamydia trachomatis methionine aminopeptidase 0.0041 0.1042 1
Brugia malayi PAS domain containing protein 0.0047 0.1238 0.2354
Trichomonas vaginalis tubulin alpha chain, putative 0.0031 0.0701 0.2371
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.0041 0.1042 0.3372
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0847 0.124
Leishmania major beta tubulin 0.0076 0.2253 0.2228
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0044 0.1126 0.1647
Brugia malayi bZIP transcription factor family protein 0.0081 0.2421 0.4712
Schistosoma mansoni adapter molecule crk 0.0013 0.0057 0.0086
Loa Loa (eye worm) tubulin alpha-2 chain 0.0094 0.2852 0.4153
Schistosoma mansoni protein kinase 0.0015 0.0122 0.0184
Echinococcus multilocularis tubulin subunit beta 0.0076 0.2253 0.3296
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0012 0.0022 0.0032
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.1642 0.2485
Schistosoma mansoni tubulin subunit beta 0.0076 0.2253 0.3409
Leishmania major beta tubulin 0.0076 0.2253 0.2228
Leishmania major protein kinase, putative 0.0013 0.0043 0.001
Trypanosoma cruzi tubulin gamma chain 0.0088 0.2653 0.2629
Echinococcus granulosus tubulin alpha chain 0.0094 0.2852 0.4172
Echinococcus multilocularis tubulin gamma 1 chain 0.0088 0.2653 0.3881
Echinococcus multilocularis growth factor receptor bound protein 2 0.0013 0.0057 0.0083
Trichomonas vaginalis tubulin, putative 0.0056 0.1561 0.5422
Echinococcus granulosus tubulin alpha chain 0.0094 0.2852 0.4172
Leishmania major protein kinase, putative 0.0013 0.0043 0.001
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0062 0.1748 0.5957
Trichomonas vaginalis tubulin beta chain, putative 0.0094 0.2852 1
Toxoplasma gondii beta tubulin 0.0076 0.2253 0.7807
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0093 0.0071
Loa Loa (eye worm) hypothetical protein 0.0013 0.0057 0.0051
Schistosoma mansoni tubulin subunit beta 0.003 0.0656 0.0993
Echinococcus multilocularis calcium dependent protein kinase 0.0015 0.0112 0.0163
Echinococcus granulosus tyrosine protein kinase Lyn 0.0044 0.1136 0.1662
Treponema pallidum methionine aminopeptidase (map) 0.0041 0.1042 1
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0656 0.2213
Loa Loa (eye worm) hypothetical protein 0.0026 0.0495 0.0695
Leishmania major beta tubulin 0.0076 0.2253 0.2228
Loa Loa (eye worm) hypothetical protein 0.0012 0.0028 0.0009
Entamoeba histolytica tubulin alpha-1 chain 0.0094 0.2852 1
Loa Loa (eye worm) tubulin beta-1 chain 0.0076 0.2253 0.3275
Leishmania major beta tubulin 0.0076 0.2253 0.2228
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0012 0.0032 0.0047
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0015 0.0122 0.0178
Echinococcus multilocularis musashi 0.0026 0.0512 0.0749
Echinococcus multilocularis tubulin alpha chain 0.0094 0.2852 0.4172
Plasmodium falciparum alpha tubulin 2 0.0094 0.2852 1
Echinococcus granulosus Tubulin alpha 1 chain 0.0094 0.2852 0.4172
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0148 0.4737 0.6919
Echinococcus multilocularis Tubulin alpha 1 chain 0.0094 0.2852 0.4172
Echinococcus granulosus Tubulin alpha 1 chain 0.0094 0.2852 0.4172
Schistosoma mansoni hypothetical protein 0.0164 0.5284 0.7995
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0045 0.0065
Echinococcus granulosus peroxisome assembly protein 26 0.0094 0.2852 0.4172
Loa Loa (eye worm) TK protein kinase 0.0037 0.0904 0.1295
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0847 0.0818
Echinococcus granulosus beta tubulin 0.0076 0.2253 0.3296
Loa Loa (eye worm) BEN-1 protein 0.0076 0.2253 0.3275
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0044 0.1126 0.1647
Loa Loa (eye worm) hypothetical protein 0.0063 0.1805 0.2616
Trichomonas vaginalis tubulin, putative 0.0076 0.2253 0.7877
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0044 0.1126 0.1647
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.1642 1
Schistosoma mansoni tyrosine kinase 0.0016 0.0149 0.0225
Trypanosoma cruzi beta tubulin, putative 0.0076 0.2253 0.2228
Loa Loa (eye worm) tubulin alpha-3 chain 0.0062 0.176 0.2551
Entamoeba histolytica tubulin family protein 0.0076 0.2253 0.7807
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.1642 0.2485
Onchocerca volvulus Huntingtin homolog 0.0118 0.3712 0.8419
Echinococcus granulosus tyrosine protein kinase Src42A 0.0035 0.0812 0.1188
Plasmodium falciparum tubulin delta chain, putative 0.003 0.0656 0.1957
Loa Loa (eye worm) hypothetical protein 0.0118 0.3712 0.5415
Echinococcus multilocularis hypothetical protein 0.0094 0.2852 0.4172
Brugia malayi Tubulin alpha-2 chain 0.0094 0.2852 0.557
Trichomonas vaginalis tubulin epsilon chain, putative 0.003 0.0656 0.2213
Plasmodium falciparum tubulin beta chain 0.0076 0.2253 0.7807
Echinococcus multilocularis tubulin beta 1 chain 0.0076 0.2253 0.3296
Loa Loa (eye worm) alpha-tubulin 0.0094 0.2852 0.4153
Plasmodium vivax methionine aminopeptidase 1a, putative 0.0041 0.1042 0.3372
Trypanosoma cruzi tubulin delta chain 0.003 0.0656 0.0626
Echinococcus granulosus aryl hydrocarbon receptor 0.0012 0.0032 0.0047
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0847 0.2891
Trichomonas vaginalis tubulin gamma chain, putative 0.003 0.0656 0.2213
Leishmania major beta tubulin 0.0076 0.2253 0.2228
Entamoeba histolytica tubulin family protein 0.0076 0.2253 0.7807
Giardia lamblia Gamma tubulin 0.0088 0.2653 0.9094
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0512 0.0907
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.1642 1
Schistosoma mansoni lamin 0.0026 0.0512 0.0775
Leishmania major alpha tubulin 0.0094 0.2852 0.2829
Loa Loa (eye worm) tubulin alpha 2 0.0032 0.0713 0.1014
Schistosoma mansoni tubulin subunit delta 0.003 0.0656 0.0993
Brugia malayi Tubulin beta-1 chain 0.0076 0.2253 0.4377
Schistosoma mansoni alpha tubulin 0.0094 0.2852 0.4315
Leishmania major beta tubulin 0.0076 0.2253 0.2228
Trichomonas vaginalis tubulin gamma chain, putative 0.0088 0.2653 0.9295
Giardia lamblia Beta tubulin 0.0076 0.2253 0.7273
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0847 0.1575
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0512 0.0719
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0847 0.0818
Trypanosoma brucei epsilon tubulin 0.0062 0.1748 0.1647
Loa Loa (eye worm) tubulin alpha chain 0.0094 0.2852 0.4153
Trichomonas vaginalis tubulin alpha chain, putative 0.0076 0.2253 0.7877
Trichomonas vaginalis tubulin epsilon chain, putative 0.0076 0.2253 0.7877
Onchocerca volvulus 0.0133 0.4231 0.9607
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.003 0.0656 0.1957
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0093 0.0104
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0015 0.0122 0.0178
Plasmodium vivax tubulin alpha chain, putative 0.0094 0.2852 1
Echinococcus granulosus Tubulin beta 2C chain 0.0076 0.2253 0.3296
Trichomonas vaginalis tubulin beta chain, putative 0.0094 0.2852 1
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.0041 0.1042 0.0932
Schistosoma mansoni tubulin subunit gamma 0.0088 0.2653 0.4014
Echinococcus multilocularis tubulin delta chain 0.003 0.0656 0.096
Schistosoma mansoni aryl hydrocarbon receptor 0.0047 0.1238 0.1873
Schistosoma mansoni single-minded 0.0047 0.1238 0.1873
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0081 0.2421 0.3542
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0035 0.0812 0.1188
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.1642 0.2403
Echinococcus granulosus tyrosine protein kinase Blk 0.0037 0.0904 0.1323
Echinococcus granulosus Tubulin beta 2C chain 0.0076 0.2253 0.3296
Leishmania major alpha tubulin 0.0094 0.2852 0.2829
Plasmodium vivax tubulin alpha chain, putative 0.0094 0.2852 1
Leishmania major alpha tubulin 0.0094 0.2852 0.2829
Trichomonas vaginalis tubulin epsilon chain, putative 0.0094 0.2852 1
Echinococcus granulosus Tubulin beta 2C chain 0.0076 0.2253 0.3296
Brugia malayi hypothetical protein 0.0118 0.3712 0.7284
Leishmania major beta tubulin 0.0076 0.2253 0.2228
Echinococcus multilocularis aryl hydrocarbon receptor 0.0012 0.0032 0.0047
Echinococcus granulosus tubulin alpha 3 chain 0.0094 0.2852 0.4172
Giardia lamblia Beta tubulin 0.0076 0.2253 0.7273
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0044 0.1126 0.1647
Trypanosoma brucei methionine aminopeptidase, putative 0.0041 0.1042 0.0932
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0015 0.0122 0.0178
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.0041 0.1042 0.0932
Plasmodium vivax methionine aminopeptidase 1b, putative 0.0041 0.1042 0.3372
Leishmania major delta tubulin, putative 0.003 0.0656 0.0626
Toxoplasma gondii beta-1 tubulin, putative 0.0076 0.2253 0.7807
Echinococcus multilocularis tubulin alpha chain 0.0094 0.2852 0.4172
Mycobacterium ulcerans methionine aminopeptidase MapB 0.0041 0.1042 0.3916
Echinococcus multilocularis tubulin epsilon chain 0.0062 0.1748 0.2557
Echinococcus granulosus roundabout 2 0.0014 0.0102 0.0149
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0015 0.0122 0.0146
Loa Loa (eye worm) hypothetical protein 0.0026 0.0512 0.0719
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0815 0.1192
Echinococcus granulosus intermediate filament protein 0.0026 0.0512 0.0749
Trypanosoma brucei tubulin delta chain 0.003 0.0656 0.0541
Echinococcus multilocularis c src tyrosine kinase 0.0016 0.0149 0.0218
Entamoeba histolytica tubulin gamma chain 0.0088 0.2653 0.9271
Leishmania major alpha tubulin 0.0094 0.2852 0.2829
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0847 0.124
Brugia malayi alpha-tubulin 0.0094 0.2852 0.557
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.0041 0.1042 0.3916
Echinococcus multilocularis Tubulin alpha 1 chain 0.0094 0.2852 0.4172
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0847 0.124
Trichomonas vaginalis tubulin epsilon chain, putative 0.0076 0.2253 0.7877
Echinococcus granulosus tubulin beta 1 chain 0.0076 0.2253 0.3296
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0847 0.1282
Trypanosoma brucei beta tubulin 0.0076 0.2253 0.2158
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0847 0.0871
Echinococcus granulosus tubulin alpha 1C chain 0.0094 0.2852 0.4172
Schistosoma mansoni alpha tubulin 0.0094 0.2852 0.4315
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0081 0.2421 0.3542
Echinococcus granulosus jun protein 0.0081 0.2421 0.3542
Loa Loa (eye worm) hypothetical protein 0.0079 0.2344 0.3408
Trypanosoma brucei epsilon tubulin 0.0062 0.1748 0.1647
Echinococcus multilocularis Tubulin beta 2C chain 0.0076 0.2253 0.3296
Loa Loa (eye worm) hypothetical protein 0.0094 0.2852 0.4153
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.0043 0.001
Leishmania major epsilon tubulin, putative 0.0062 0.1748 0.1721
Onchocerca volvulus 0.0026 0.0512 0.1098
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0015 0.0122 0.0178
Schistosoma mansoni hypothetical protein 0.005 0.1341 0.2029
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0094 0.2852 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.0094 0.2852 0.4172
Echinococcus multilocularis tubulin alpha chain 0.0094 0.2852 0.4172
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0847 0.2891
Toxoplasma gondii alpha-tubulin I, putative 0.0094 0.2852 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0102 0.0117
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0037 0.0904 0.1323
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0512 0.0719
Echinococcus granulosus tyrosine protein kinase Src42A 0.0044 0.1126 0.1647
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0016 0.0149 0.0218
Leishmania major beta tubulin 0.0076 0.2253 0.2228
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0041 0.1042 0.1013
Schistosoma mansoni tubulin subunit beta 0.0076 0.2253 0.3409
Echinococcus granulosus Tubulin alpha 1 chain 0.0094 0.2852 0.4172
Echinococcus granulosus tyrosine protein kinase Fyn 0.0044 0.1126 0.1647
Brugia malayi Cam kinase protein 1 0.0015 0.0122 0.0129
Trypanosoma brucei zeta tubulin, putative 0.03 1 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0847 0.0735
Schistosoma mansoni cell adhesion molecule 0.0012 0.0022 0.0033
Echinococcus granulosus tubulin epsilon chain 0.0062 0.1748 0.2557
Loa Loa (eye worm) hypothetical protein 0.0012 0.0028 0.0009
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0015 0.0122 0.0178
Schistosoma mansoni tubulin subunit alpha 0.0094 0.2852 0.4315
Leishmania major gamma-tubulin 0.0088 0.2653 0.2629
Leishmania major beta tubulin 0.0076 0.2253 0.2228
Trichomonas vaginalis tubulin beta chain, putative 0.0094 0.2852 1
Echinococcus granulosus tubulin delta chain 0.003 0.0656 0.096
Loa Loa (eye worm) hypothetical protein 0.0036 0.0847 0.1211
Echinococcus multilocularis tyrosine protein kinase HCK 0.0031 0.0677 0.0991
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0045 0.0065
Brugia malayi Methionine aminopeptidase protein type I 0.0041 0.1042 0.1964
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.003 0.0656 0.1957
Plasmodium falciparum tubulin gamma chain 0.0088 0.2653 0.9271
Schistosoma mansoni tubulin subunit alpha 0.0094 0.2852 0.4315
Giardia lamblia Alpha-tubulin 0.0094 0.2852 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.1642 0.2403
Echinococcus multilocularis geminin 0.0164 0.5284 0.773
Trichomonas vaginalis tubulin beta chain, putative 0.0076 0.2253 0.7877
Echinococcus multilocularis lamin dm0 0.0026 0.0512 0.0749
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0043 0.001
Echinococcus multilocularis tubulin alpha 1C chain 0.0094 0.2852 0.4172
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0013 0.0057 0.0051
Trypanosoma brucei beta tubulin 0.0076 0.2253 0.2158
Onchocerca volvulus 0.0026 0.0512 0.1098
Toxoplasma gondii alpha tubulin TUBA1 0.0094 0.2852 1
Trichomonas vaginalis tubulin beta chain, putative 0.0031 0.0701 0.2371
Leishmania major alpha tubulin 0.0094 0.2852 0.2829
Leishmania major alpha tubulin 0.0094 0.2852 0.2829
Trypanosoma brucei alpha tubulin 0.0094 0.2852 0.2764
Brugia malayi Tubulin alpha chain 0.0094 0.2852 0.557
Schistosoma mansoni tyrosine kinase 0.0044 0.1126 0.1703
Onchocerca volvulus 0.0031 0.0701 0.1529
Brugia malayi Tyrosine-protein kinase abl-1 0.0092 0.2791 0.5447
Echinococcus multilocularis tubulin alpha 3 chain 0.0094 0.2852 0.4172
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0847 0.124
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0015 0.0122 0.0178
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0015 0.0122 0.0146
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0062 0.176 0.6128
Brugia malayi hypoxia-induced factor 1 0.0145 0.4652 0.9156
Onchocerca volvulus 0.0064 0.1817 0.4084
Loa Loa (eye worm) hypothetical protein 0.0062 0.176 0.2551
Trichomonas vaginalis tubulin alpha chain, putative 0.0031 0.0701 0.2371
Echinococcus granulosus growth factor receptor bound protein 2 0.0013 0.0057 0.0083
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0044 0.1126 0.1647
Loa Loa (eye worm) hypoxia-induced factor 1 0.0145 0.4652 0.6794
Loa Loa (eye worm) TK protein kinase 0.0031 0.0677 0.0962
Trypanosoma brucei epsilon tubulin 0.0062 0.1748 0.1647
Trichomonas vaginalis tubulin beta chain, putative 0.0094 0.2852 1
Trypanosoma brucei alpha tubulin, putative 0.0031 0.0701 0.0586
Echinococcus multilocularis Tubulin beta 2C chain 0.0076 0.2253 0.3296
Trypanosoma brucei beta tubulin 0.0062 0.1748 0.1647
Brugia malayi beta-tubulin, identical 0.0076 0.2253 0.4377
Loa Loa (eye worm) methionine aminopeptidase type I 0.0041 0.1042 0.1497
Schistosoma mansoni tubulin subunit epsilon 0.0062 0.1748 0.2645
Schistosoma mansoni growth factor receptor-bound protein 0.0013 0.0057 0.0086
Schistosoma mansoni lamin 0.0026 0.0512 0.0775
Leishmania major alpha tubulin 0.0094 0.2852 0.2829
Echinococcus multilocularis peroxisome assembly protein 26 0.0094 0.2852 0.4172
Plasmodium vivax tubulin epsilon chain, putative 0.0062 0.1748 0.5957
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0037 0.0904 0.1323
Schistosoma mansoni tubulin subunit alpha 0.0094 0.2852 0.4315
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0063 0.1805 0.6286
Leishmania major beta tubulin 0.0076 0.2253 0.2228
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0041 0.1042 0.1013
Trypanosoma cruzi zeta tubulin, putative 0.03 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.0122 0.0184
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0847 0.2891
Leishmania major beta tubulin 0.0076 0.2253 0.2228
Brugia malayi SRC-1 0.0044 0.1126 0.213
Echinococcus granulosus tubulin alpha chain 0.0094 0.2852 0.4172
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0015 0.0122 0.0178
Trichomonas vaginalis CAMK family protein kinase 0.0015 0.0122 0.0317
Brugia malayi Tubulin gamma chain 0.0088 0.2653 0.5174
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0012 0.0032 0.0015
Plasmodium vivax delta tubulin, putative 0.003 0.0656 0.1957
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0044 0.1126 0.1647
Trypanosoma brucei alpha tubulin 0.0094 0.2852 0.2764
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0044 0.1126 0.1647
Schistosoma mansoni tyrosine kinase 0.0044 0.1126 0.1703
Echinococcus multilocularis Tubulin beta 2C chain 0.0076 0.2253 0.3296
Echinococcus granulosus alpha tubulin 0.0094 0.2852 0.4172
Schistosoma mansoni jun-related protein 0.0066 0.1895 0.2866
Brugia malayi Immunoglobulin I-set domain containing protein 0.0148 0.4737 0.9326
Leishmania major alpha tubulin 0.0094 0.2852 0.2829
Echinococcus granulosus c src tyrosine kinase 0.0016 0.0149 0.0218
Trichomonas vaginalis tubulin gamma chain, putative 0.0062 0.1748 0.6085
Trypanosoma cruzi epsilon tubulin, putative 0.0062 0.1748 0.1721
Loa Loa (eye worm) hypothetical protein 0.0012 0.0032 0.0015

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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