TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 750.861 | Formula: C37H46N6O9S
H donors: 4 H acceptors: 8 LogP: 4.42 Rotable bonds: 18
Rule of 5 violations (Lipinski): 2
SMILES: COc1ccc2c(c1)nc(cc2O[C@@H]1C[C@H](N(C1)C(=O)[C@H](C(C)(C)C)OC(=O)NC(C)(C)C)C(=O)N[C@@]1(C[C@H]1C=C)C(=O)O)c1csc(n1)NC(=O)C
InChi: 1S/C37H46N6O9S/c1-10-20-16-37(20,32(47)48)41-30(45)27-14-22(17-43(27)31(46)29(35(3,4)5)52-34(49)42-36(6,7)8)51-28-15-25(26-18-53-33(40-26)38-19(2)44)39-24-13-21(50-9)11-12-23(24)28/h10-13,15,18,20,22,27,29H,1,14,16-17H2,2-9H3,(H,41,45)(H,42,49)(H,47,48)(H,38,40,44)/t20-,22-,27+,29-,37-/m1/s1
InChiKey: GFMMVRTWHRTZEA-XAMHVCGRSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Giardia lamblia	Kinase, AGC PKA	0.0045	0.0698	0.5
Loa Loa (eye worm)	uncoordinated protein 104	0.0012	0.0104	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0104	0.0104
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0012	0.0113	0.0074
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0012	0.0113	0.0151
Loa Loa (eye worm)	oxysterol binding protein	0.0012	0.0104	0.0104
Onchocerca volvulus		0.0012	0.0104	0.5
Entamoeba histolytica	protein kinase, putative	0.0079	0.1317	1
Schistosoma mansoni	serine/threonine protein kinase	0.0023	0.0307	0.0307
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0104	0.0104
Trichomonas vaginalis	guanyl-nucleotide exchange factor, putative	0.0014	0.0145	0.0339
Trichomonas vaginalis	AGC family protein kinase	0.0079	0.1317	1
Schistosoma mansoni	hypothetical protein	0.0012	0.0104	0.0104
Schistosoma mansoni	dynamin	0.0012	0.0104	0.0104
Echinococcus granulosus	DCC interacting protein 13 beta	0.0012	0.0104	0.0104
Brugia malayi	Protein kinase domain containing protein	0.0079	0.1317	0.1317
Brugia malayi	Variant SH3 domain containing protein	0.0014	0.0152	0.0152
Entamoeba histolytica	hypothetical protein	0.0012	0.0113	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.0023	0.0307	0.1676
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0104	0.0104
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0012	0.0104	0.0104
Echinococcus granulosus	protein kinase C gamma type	0.0023	0.0307	0.0307
Loa Loa (eye worm)	syntrophin-1	0.0012	0.0104	0.0104
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0056	0.0911	1
Echinococcus multilocularis	indoleamine 2,3 dioxygenase 2	0.056	1	1
Leishmania major	folate/biopterin transporter, putative	0.0012	0.0113	1
Brugia malayi	Cytohesin 3	0.0202	0.3528	0.3528
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0012	0.0104	0.0104
Leishmania major	serine/threonine-protein kinase a, putative	0.0012	0.0113	1
Onchocerca volvulus		0.0012	0.0104	0.5
Echinococcus multilocularis	cytohesin 1	0.0202	0.3528	0.3528
Trichomonas vaginalis	AGC family protein kinase	0.0012	0.0113	0.0074
Schistosoma mansoni	myotubularin-related protein	0.0012	0.0104	0.0104
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0012	0.0104	0.0104
Echinococcus multilocularis	oxysterol binding protein 9	0.0012	0.0104	0.0104
Schistosoma mansoni	atypical protein kinase C	0.0023	0.0307	0.0307
Entamoeba histolytica	protein kinase, putative	0.0012	0.0113	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.0012	0.0113	0.0074
Leishmania major	protein kinase, putative	0.0012	0.0113	1
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0012	0.0113	0.009
Brugia malayi	Oxysterol binding protein	0.0012	0.0104	0.0104
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0023	0.0307	0.0307
Trichomonas vaginalis	AGC family protein kinase	0.0012	0.0113	0.0074
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0012	0.0104	0.0104
Trichomonas vaginalis	AGC family protein kinase	0.0012	0.0113	0.0074
Echinococcus granulosus	nervana 2	0.0044	0.0689	0.0689
Trichomonas vaginalis	AGC family protein kinase	0.0023	0.0307	0.1676
Echinococcus granulosus	Pleckstrin y	0.0012	0.0104	0.0104
Echinococcus granulosus	serine threonine protein kinase nrc	0.0045	0.0698	0.0698
Schistosoma mansoni	serine/threonine-protein kinase	0.0056	0.0911	0.0911
Trichomonas vaginalis	AGC family protein kinase	0.0012	0.0113	0.0074
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0012	0.0104	0.0104
Onchocerca volvulus		0.0012	0.0104	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0023	0.0307	0.0307
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0012	0.0104	0.0104
Toxoplasma gondii	AGC kinase	0.0067	0.1105	1
Schistosoma mansoni	centaurin alpha	0.0012	0.0104	0.0104
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0023	0.0307	0.0307
Trichomonas vaginalis	AGC family protein kinase	0.0012	0.0113	0.0074
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0012	0.0113	0.0111
Brugia malayi	p70 ribosomal S6 kinase beta	0.0067	0.1105	0.1105
Trichomonas vaginalis	AGC family protein kinase	0.0079	0.1317	1
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0012	0.0104	0.0104
Entamoeba histolytica	hypothetical protein	0.0012	0.0113	0.0074
Schistosoma mansoni	growth factor receptor-bound protein	0.0012	0.0104	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0307	0.0307
Trichomonas vaginalis	AGC family protein kinase	0.0012	0.0113	0.0074
Echinococcus multilocularis	serine threonine protein kinase	0.0023	0.0307	0.0307
Echinococcus multilocularis	Pleckstrin y	0.0012	0.0104	0.0104
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0014	0.0152	0.0152
Trichomonas vaginalis	AGC family protein kinase	0.0012	0.0113	0.0074
Echinococcus multilocularis	oxysterol binding protein 3	0.0012	0.0104	0.0104
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0012	0.0104	0.0104
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0012	0.0113	0.0111
Brugia malayi	PH domain containing protein	0.0012	0.0104	0.0104
Echinococcus multilocularis	oxysterol binding protein 1	0.0012	0.0104	0.0104
Entamoeba histolytica	protein kinase, putative	0.0012	0.0113	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.0012	0.0113	0.0074
Echinococcus granulosus	beta 1 syntrophin	0.0012	0.0104	0.0104
Brugia malayi	Dynamin	0.0012	0.0104	0.0104
Trypanosoma cruzi	NIMA-related kinase, putative	0.0012	0.0113	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0104	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0104	0.0104
Echinococcus granulosus	Oxysterol binding protein 11	0.0012	0.0104	0.0104
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0012	0.0104	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0104	0.0104
Entamoeba histolytica	protein kinase, putative	0.0012	0.0113	0.0074
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0012	0.0104	0.0104
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0044	0.0689	0.0689
Schistosoma mansoni	goodpasture antigen-binding protein	0.0012	0.0104	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0104	0.0104
Schistosoma mansoni	serine/threonine protein kinase	0.0023	0.0307	0.0307
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0012	0.0104	0.0104
Echinococcus granulosus	pleckstrin y domain containing family A	0.0012	0.0104	0.0104
Schistosoma mansoni	serine/threonine protein kinase	0.0023	0.0307	0.0307
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0023	0.0307	0.0307
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0045	0.0698	0.0698
Brugia malayi	Uncoordinated protein 104	0.0012	0.0104	0.0104
Echinococcus granulosus	Pleckstrin y	0.0012	0.0104	0.0104
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0012	0.0104	0.0104
Echinococcus multilocularis	beta 1 syntrophin	0.0012	0.0104	0.0104
Brugia malayi	PH domain containing protein	0.0012	0.0104	0.0104
Echinococcus multilocularis	rac serine:threonine kinase	0.0056	0.0911	0.0911
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0014	0.0151	0.0151
Echinococcus granulosus	protein kinase c iota type	0.0023	0.0307	0.0307
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0012	0.0104	0.0104
Leishmania major	protein kinase, putative	0.0012	0.0113	1
Echinococcus multilocularis	actin binding protein anillin	0.0012	0.0104	0.0104
Echinococcus multilocularis	protein kinase c epsilon type	0.0023	0.0307	0.0307
Trichomonas vaginalis	AGC family protein kinase	0.0079	0.1317	1
Trichomonas vaginalis	AGC family protein kinase	0.0012	0.0113	0.0074
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0012	0.0113	0.0074
Echinococcus multilocularis	nervana 2	0.0044	0.0689	0.0689
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0056	0.0911	0.6647
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0147	0.2538	0.2538
Trichomonas vaginalis	AGC family protein kinase	0.0012	0.0113	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.0012	0.0113	0.0074
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0023	0.0307	0.0307
Echinococcus granulosus	protein kinase c epsilon type	0.0023	0.0307	0.0307
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0067	0.1105	0.1105
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0104	0.0104
Schistosoma mansoni	hypothetical protein	0.0012	0.0104	0.0104
Loa Loa (eye worm)	PH domain-containing protein	0.0012	0.0104	0.0104
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0012	0.0104	0.0104
Onchocerca volvulus	Abnormal cell migration protein 10 homolog	0.0012	0.0104	0.5
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0012	0.0104	0.0104
Brugia malayi	Hr1 repeat family protein	0.0023	0.0307	0.0307
Brugia malayi	Plekhf2 protein	0.0012	0.0104	0.0104
Trichomonas vaginalis	AGC family protein kinase	0.0023	0.0307	0.1676
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0014	0.0151	0.0151
Echinococcus granulosus	serine:threonine protein kinase N2	0.0023	0.0307	0.0307
Onchocerca volvulus		0.0012	0.0104	0.5
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0104	0.0104
Onchocerca volvulus		0.0012	0.0104	0.5
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0006	0.0009	0.0009
Schistosoma mansoni	tyrosine kinase	0.0144	0.2491	0.2491
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0012	0.0113	0.0111
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0012	0.0104	0.0104
Schistosoma mansoni	serine/threonine protein kinase	0.0023	0.0307	0.0307
Schistosoma mansoni	hypothetical protein	0.056	1	1
Trichomonas vaginalis	AGC family protein kinase	0.0012	0.0113	0.0074
Echinococcus granulosus	oxysterol binding protein 9	0.0012	0.0104	0.0104
Echinococcus multilocularis	dynamin 1	0.0012	0.0104	0.0104
Echinococcus multilocularis	Pleckstrin y	0.0012	0.0104	0.0104
Brugia malayi	Syntrophin-1	0.0012	0.0104	0.0104
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0012	0.0113	0.0111
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0012	0.0104	0.0104
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0012	0.0104	0.0104
Schistosoma mansoni	serine/threonine-protein kinase	0.0056	0.0911	0.0911
Onchocerca volvulus	Protein melted homolog	0.0012	0.0104	0.5
Entamoeba histolytica	protein kinase, putative	0.0067	0.1105	0.8249
Echinococcus granulosus	oxysterol binding protein 1	0.0012	0.0104	0.0104
Trichomonas vaginalis	AGC family protein kinase	0.0012	0.0113	0.0074
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0012	0.0113	0.0074
Loa Loa (eye worm)	cytohesin 3	0.0202	0.3528	0.3528
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0045	0.0698	0.0698
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0012	0.0113	0.0111
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0023	0.0307	0.0307
Brugia malayi	Dynamin	0.0012	0.0104	0.0104
Schistosoma mansoni	vav2	0.0014	0.0152	0.0152
Schistosoma mansoni	hypothetical protein	0.0012	0.0104	0.0104
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0012	0.0113	0.0074
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0012	0.0104	0.0104
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0012	0.0104	0.0104
Brugia malayi	PH domain containing protein	0.0012	0.0104	0.0104
Onchocerca volvulus		0.0012	0.0104	0.5
Brugia malayi	Oxysterol-binding protein	0.0012	0.0104	0.0104
Brugia malayi	Cadps2 protein	0.0012	0.0104	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0104	0.0104
Onchocerca volvulus	Putative zinc finger protein	0.0012	0.0104	0.5
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0012	0.0113	0.0074
Brugia malayi	probable spectrin beta chain	0.0012	0.0104	0.0104
Trichomonas vaginalis	protein transport protein sec7, putative	0.0014	0.0145	0.0339
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0079	0.1317	0.1317
Echinococcus granulosus	Pleckstrin y	0.0012	0.0104	0.0104
Trichomonas vaginalis	AGC family protein kinase	0.0012	0.0113	0.0074
Echinococcus granulosus	calcium dependent secretion activator 1	0.0012	0.0104	0.0104
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0012	0.0104	0.0104
Entamoeba histolytica	protein kinase, putative	0.0012	0.0113	0.0074
Toxoplasma gondii	protein kinase domain-containing protein	0.0012	0.0113	0.009
Echinococcus granulosus	Glutaredoxin protein 5	0.0044	0.0689	0.0689
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0023	0.0307	0.0307
Trichomonas vaginalis	AGC family protein kinase	0.0012	0.0113	0.0074
Brugia malayi	MAX-1A	0.0012	0.0104	0.0104
Echinococcus multilocularis	Oxysterol binding protein 11	0.0012	0.0104	0.0104
Echinococcus granulosus	dynamin 1	0.0012	0.0104	0.0104
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0044	0.0689	0.0689
Echinococcus multilocularis	myotubularin protein 13	0.0012	0.0104	0.0104
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0012	0.0113	0.0111
Schistosoma mansoni	hypothetical protein	0.056	1	1
Trichomonas vaginalis	AGC family protein kinase	0.0079	0.1317	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0152	0.0152
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.0045	0.0698	1
Onchocerca volvulus	outspread protein homolog	0.0012	0.0104	0.5
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0012	0.0113	0.0151
Entamoeba histolytica	protein kinase 2, putative	0.0045	0.0698	0.4896
Echinococcus granulosus	pdz domain containing protein	0.0012	0.0104	0.0104
Brugia malayi	hypothetical protein	0.0012	0.0104	0.0104
Schistosoma mansoni	dynamin	0.0012	0.0104	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0104	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0104	0.0104
Echinococcus multilocularis	pdz domain containing protein	0.0012	0.0104	0.0104
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0012	0.0104	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0104	0.0104
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0023	0.0307	0.0307
Brugia malayi	protein kinase C II.	0.0023	0.0307	0.0307
Trichomonas vaginalis	AGC family protein kinase	0.0079	0.1317	1
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0202	0.3528	0.3528
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0023	0.0307	0.0307
Brugia malayi	TBC domain containing protein	0.0012	0.0104	0.0104
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0012	0.0104	0.0104
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0023	0.0307	0.0307
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0023	0.0307	0.0307
Loa Loa (eye worm)	rho-GTPase-activating	0.0012	0.0104	0.0104
Entamoeba histolytica	protein kinase, putative	0.0079	0.1317	1
Entamoeba histolytica	p21-activated kinase	0.0012	0.0113	0.0074
Schistosoma mansoni	zinc finger protein	0.0012	0.0104	0.0104
Schistosoma mansoni	rho gtpase activating protein	0.0012	0.0104	0.0104
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0012	0.0113	0.0074
Schistosoma mansoni	goodpasture antigen-binding protein	0.0012	0.0104	0.0104
Brugia malayi	PH domain containing protein	0.0012	0.0104	0.0104
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0023	0.0307	0.0307
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0104	0.0104
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0012	0.0113	0.0111
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0023	0.0307	0.0307
Onchocerca volvulus		0.0012	0.0104	0.5
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0023	0.0307	0.0307
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.0045	0.0698	1
Brugia malayi	PH domain containing protein	0.0012	0.0104	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0104	0.0104
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0012	0.0104	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0104	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0104	0.0104
Brugia malayi	PH domain containing protein	0.0012	0.0104	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0104	0.0104
Echinococcus granulosus	oxysterol binding protein 3	0.0012	0.0104	0.0104
Schistosoma mansoni	serine/threonine protein kinase	0.0023	0.0307	0.0307
Trichomonas vaginalis	AGC family protein kinase	0.0012	0.0113	0.0074
Echinococcus multilocularis	Pleckstrin y	0.0012	0.0104	0.0104
Trichomonas vaginalis	protein transport protein sec7, putative	0.0014	0.0145	0.0339
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0079	0.1317	1
Trichomonas vaginalis	AGC family protein kinase	0.0012	0.0113	0.0074
Entamoeba histolytica	hypothetical protein	0.0014	0.0151	0.0386
Entamoeba histolytica	protein kinase, putative	0.0012	0.0113	0.0074
Echinococcus multilocularis	Glutaredoxin protein 5	0.0044	0.0689	0.0689
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0012	0.0104	0.0104
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0014	0.0151	0.0151
Trichomonas vaginalis	AGC family protein kinase	0.0079	0.1317	1
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0012	0.0113	0.0074
Brugia malayi	PH domain containing protein	0.0012	0.0104	0.0104
Echinococcus granulosus	NDR protein kinase	0.0023	0.0307	0.0307
Trichomonas vaginalis	AGC family protein kinase	0.0035	0.052	0.3427
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0012	0.0104	0.0104
Schistosoma mansoni	hypothetical protein	0.0012	0.0104	0.0104
Loa Loa (eye worm)	Plekhf2 protein	0.0012	0.0104	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0104	0.0104
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0012	0.0113	1
Trichomonas vaginalis	AGC family protein kinase	0.0079	0.1317	1
Trypanosoma cruzi	NIMA-related kinase, putative	0.0012	0.0113	0.0111
Echinococcus granulosus	cytohesin 1	0.0202	0.3528	0.3528
Echinococcus multilocularis	protein kinase c iota type	0.0023	0.0307	0.0307
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0012	0.0113	0.0074
Echinococcus granulosus	Protein kinase C brain isozyme	0.0023	0.0307	0.0307
Brugia malayi	Pleckstrin Homology Domain	0.0012	0.0104	0.0104
Brugia malayi	Variant SH3 domain containing protein	0.0012	0.0104	0.0104
Echinococcus multilocularis	nervana 2	0.0044	0.0689	0.0689
Loa Loa (eye worm)	indoleamine 2,3-dioxygenase	0.056	1	1
Echinococcus granulosus	myotubularin protein 13	0.0012	0.0104	0.0104
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0012	0.0113	0.0074
Entamoeba histolytica	protein kinase, putative	0.0023	0.0307	0.1676
Echinococcus granulosus	GRB2 associated binding protein 3	0.0012	0.0104	0.0104
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0023	0.0298	0.1602
Schistosoma mansoni	oxysterol-binding protein 1	0.0012	0.0104	0.0104
Brugia malayi	Protein kinase domain containing protein	0.0023	0.0307	0.0307
Brugia malayi	PH domain containing protein	0.0012	0.0104	0.0104
Schistosoma mansoni	serine/threonine protein kinase	0.0023	0.0307	0.0307
Echinococcus granulosus	serine/threonine protein kinase	0.0056	0.0911	0.0911
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0147	0.2538	0.2538
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0045	0.0698	0.7366
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0012	0.0104	0.0104
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0023	0.0307	0.0307
Trichomonas vaginalis	AGC family protein kinase	0.0012	0.0113	0.0074
Brugia malayi	Protein kinase domain containing protein	0.0023	0.0307	0.0307
Onchocerca volvulus	Putative neuronal RhoA GEF protein	0.0012	0.0104	0.5
Echinococcus granulosus	Rho GTPase activating protein 24	0.0012	0.0104	0.0104
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0056	0.0911	0.6647
Schistosoma mansoni	hypothetical protein	0.0012	0.0104	0.0104
Echinococcus granulosus	indoleamine 23 dioxygenase 2	0.056	1	1
Schistosoma mansoni	zinc finger protein	0.0012	0.0104	0.0104
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0012	0.0104	0.0104
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0023	0.0307	0.0307
Trichomonas vaginalis	AGC family protein kinase	0.0012	0.0113	0.0074
Echinococcus granulosus	nervana 2	0.0044	0.0689	0.0689
Trypanosoma cruzi	Protein kinase B	0.0056	0.0911	1
Trypanosoma brucei	protein kinase, putative	0.0012	0.0113	0.0074
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0012	0.0113	0.0074
Schistosoma mansoni	oxysterol-binding protein 1	0.0012	0.0104	0.0104
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0012	0.0113	0.0111
Brugia malayi	PH domain containing protein	0.0012	0.0104	0.0104
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0012	0.0113	1
Schistosoma mansoni	serine/threonine kinase	0.0023	0.0307	0.0307
Schistosoma mansoni	syntrophin	0.0012	0.0104	0.0104
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0023	0.0307	0.0307

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2403881

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1777017