Detailed information for compound 1777017

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 750.861 | Formula: C37H46N6O9S
  • H donors: 4 H acceptors: 8 LogP: 4.42 Rotable bonds: 18
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc2c(c1)nc(cc2O[C@@H]1C[C@H](N(C1)C(=O)[C@H](C(C)(C)C)OC(=O)NC(C)(C)C)C(=O)N[C@@]1(C[C@H]1C=C)C(=O)O)c1csc(n1)NC(=O)C
  • InChi: 1S/C37H46N6O9S/c1-10-20-16-37(20,32(47)48)41-30(45)27-14-22(17-43(27)31(46)29(35(3,4)5)52-34(49)42-36(6,7)8)51-28-15-25(26-18-53-33(40-26)38-19(2)44)39-24-13-21(50-9)11-12-23(24)28/h10-13,15,18,20,22,27,29H,1,14,16-17H2,2-9H3,(H,41,45)(H,42,49)(H,47,48)(H,38,40,44)/t20-,22-,27+,29-,37-/m1/s1
  • InChiKey: GFMMVRTWHRTZEA-XAMHVCGRSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Putative zinc finger protein 0.0012 0.0104 0.5
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0012 0.0113 0.0111
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0023 0.0307 0.0307
Entamoeba histolytica protein kinase, putative 0.0012 0.0113 0.0074
Schistosoma mansoni vav2 0.0014 0.0152 0.0152
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0012 0.0113 0.0074
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0012 0.0104 0.0104
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.0012 0.0104 0.0104
Echinococcus multilocularis nervana 2 0.0044 0.0689 0.0689
Loa Loa (eye worm) hypothetical protein 0.0012 0.0104 0.0104
Trichomonas vaginalis guanyl-nucleotide exchange factor, putative 0.0014 0.0145 0.0339
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0067 0.1105 0.1105
Loa Loa (eye worm) rho-GTPase-activating 0.0012 0.0104 0.0104
Schistosoma mansoni oxysterol-binding protein 1 0.0012 0.0104 0.0104
Trichomonas vaginalis AGC family protein kinase 0.0023 0.0307 0.1676
Loa Loa (eye worm) oxysterol binding protein 0.0012 0.0104 0.0104
Entamoeba histolytica protein kinase, putative 0.0012 0.0113 0.0074
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0023 0.0307 0.0307
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.0012 0.0104 0.0104
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0012 0.0113 1
Brugia malayi PH domain containing protein 0.0012 0.0104 0.0104
Echinococcus multilocularis protein kinase c epsilon type 0.0023 0.0307 0.0307
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0044 0.0689 0.0689
Brugia malayi Oxysterol binding protein 0.0012 0.0104 0.0104
Schistosoma mansoni dynamin 0.0012 0.0104 0.0104
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0014 0.0151 0.0151
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0012 0.0113 0.0111
Brugia malayi Variant SH3 domain containing protein 0.0014 0.0152 0.0152
Trichomonas vaginalis AGC family protein kinase 0.0012 0.0113 0.0074
Trichomonas vaginalis AGC family protein kinase 0.0012 0.0113 0.0074
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.0012 0.0104 0.0104
Echinococcus granulosus Protein kinase C brain isozyme 0.0023 0.0307 0.0307
Brugia malayi MAX-1A 0.0012 0.0104 0.0104
Onchocerca volvulus 0.0012 0.0104 0.5
Trichomonas vaginalis AGC family protein kinase 0.0012 0.0113 0.0074
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0014 0.0151 0.0151
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0045 0.0698 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0104 0.0104
Echinococcus granulosus DCC interacting protein 13 beta 0.0012 0.0104 0.0104
Echinococcus multilocularis oxysterol binding protein 9 0.0012 0.0104 0.0104
Echinococcus multilocularis oxysterol binding protein 1 0.0012 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0012 0.0104 0.0104
Echinococcus granulosus dynamin 1 0.0012 0.0104 0.0104
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0147 0.2538 0.2538
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0012 0.0113 0.0074
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0012 0.0113 0.0111
Loa Loa (eye worm) hypothetical protein 0.0012 0.0104 0.0104
Brugia malayi PH domain containing protein 0.0012 0.0104 0.0104
Schistosoma mansoni tyrosine kinase 0.0144 0.2491 0.2491
Trichomonas vaginalis AGC family protein kinase 0.0012 0.0113 0.0074
Echinococcus multilocularis Pleckstrin y 0.0012 0.0104 0.0104
Echinococcus granulosus tyrosine protein kinase Lyn 0.0006 0.0009 0.0009
Loa Loa (eye worm) PH domain-containing protein 0.0012 0.0104 0.0104
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0045 0.0698 1
Echinococcus multilocularis GRB2 associated binding protein 3 0.0012 0.0104 0.0104
Echinococcus granulosus calcium dependent secretion activator 1 0.0012 0.0104 0.0104
Echinococcus multilocularis pleckstrin y domain containing family A 0.0012 0.0104 0.0104
Brugia malayi PH domain containing protein 0.0012 0.0104 0.0104
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0147 0.2538 0.2538
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0023 0.0307 0.0307
Echinococcus granulosus Pleckstrin y 0.0012 0.0104 0.0104
Echinococcus granulosus serine/threonine protein kinase 0.0056 0.0911 0.0911
Trichomonas vaginalis AGC family protein kinase 0.0012 0.0113 0.0074
Echinococcus granulosus oxysterol binding protein 1 0.0012 0.0104 0.0104
Brugia malayi Protein kinase domain containing protein 0.0023 0.0307 0.0307
Trichomonas vaginalis AGC family protein kinase 0.0079 0.1317 1
Toxoplasma gondii AGC kinase 0.0067 0.1105 1
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0023 0.0307 0.0307
Entamoeba histolytica hypothetical protein 0.0012 0.0113 0.0074
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0012 0.0104 0.0104
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.0012 0.0104 0.0104
Schistosoma mansoni hypothetical protein 0.0012 0.0104 0.0104
Schistosoma mansoni hypothetical protein 0.0012 0.0104 0.0104
Echinococcus granulosus serine:threonine protein kinase N2 0.0023 0.0307 0.0307
Echinococcus granulosus Pleckstrin domain containing protein family B 0.0012 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0012 0.0104 0.0104
Brugia malayi Variant SH3 domain containing protein 0.0012 0.0104 0.0104
Echinococcus granulosus beta 1 syntrophin 0.0012 0.0104 0.0104
Trichomonas vaginalis AGC family protein kinase 0.0023 0.0307 0.1676
Echinococcus multilocularis Pleckstrin y 0.0012 0.0104 0.0104
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0023 0.0307 0.0307
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0023 0.0307 0.0307
Entamoeba histolytica protein kinase, putative 0.0012 0.0113 0.0074
Schistosoma mansoni zinc finger protein 0.0012 0.0104 0.0104
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0014 0.0151 0.0151
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0023 0.0307 0.0307
Loa Loa (eye worm) hypothetical protein 0.0012 0.0104 0.0104
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0012 0.0113 1
Echinococcus granulosus Rho GTPase activating protein 24 0.0012 0.0104 0.0104
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.0012 0.0104 0.0104
Echinococcus granulosus oxysterol binding protein 3 0.0012 0.0104 0.0104
Echinococcus granulosus Pleckstrin y 0.0012 0.0104 0.0104
Echinococcus multilocularis Rho GTPase activating protein 24 0.0012 0.0104 0.0104
Schistosoma mansoni myotubularin-related protein 0.0012 0.0104 0.0104
Echinococcus multilocularis actin binding protein anillin 0.0012 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0012 0.0104 0.0104
Toxoplasma gondii protein kinase domain-containing protein 0.0012 0.0113 0.009
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.0012 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0012 0.0104 0.0104
Brugia malayi PH domain containing protein 0.0012 0.0104 0.0104
Echinococcus granulosus nervana 2 0.0044 0.0689 0.0689
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0012 0.0104 0.0104
Echinococcus multilocularis oxysterol binding protein 3 0.0012 0.0104 0.0104
Brugia malayi PH domain containing protein 0.0012 0.0104 0.0104
Entamoeba histolytica protein kinase, putative 0.0079 0.1317 1
Echinococcus granulosus GRB2 associated binding protein 3 0.0012 0.0104 0.0104
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0023 0.0307 0.0307
Onchocerca volvulus Protein melted homolog 0.0012 0.0104 0.5
Brugia malayi PH domain containing protein 0.0012 0.0104 0.0104
Echinococcus multilocularis cytohesin 1 0.0202 0.3528 0.3528
Brugia malayi hypothetical protein 0.0012 0.0104 0.0104
Trichomonas vaginalis AGC family protein kinase 0.0079 0.1317 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0012 0.0113 0.0074
Trichomonas vaginalis AGC family protein kinase 0.0079 0.1317 1
Echinococcus granulosus nervana 2 0.0044 0.0689 0.0689
Trichomonas vaginalis AGC family protein kinase 0.0012 0.0113 0.0074
Entamoeba histolytica PH domain containing protein kinase, putative 0.0012 0.0113 0.0074
Loa Loa (eye worm) RhoGEF domain-containing protein 0.0012 0.0104 0.0104
Schistosoma mansoni hypothetical protein 0.056 1 1
Leishmania major folate/biopterin transporter, putative 0.0012 0.0113 1
Trichomonas vaginalis AGC family protein kinase 0.0012 0.0113 0.0074
Trichomonas vaginalis AGC family protein kinase 0.0079 0.1317 1
Trypanosoma cruzi NIMA-related kinase, putative 0.0012 0.0113 0.0111
Schistosoma mansoni zinc finger protein 0.0012 0.0104 0.0104
Echinococcus granulosus Glutaredoxin protein 5 0.0044 0.0689 0.0689
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0023 0.0307 0.0307
Trichomonas vaginalis AGC family protein kinase 0.0079 0.1317 1
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0307 0.0307
Schistosoma mansoni goodpasture antigen-binding protein 0.0012 0.0104 0.0104
Trichomonas vaginalis AGC family protein kinase 0.0012 0.0113 0.0074
Trichomonas vaginalis AGC family protein kinase 0.0012 0.0113 0.0074
Loa Loa (eye worm) uncoordinated protein 104 0.0012 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0012 0.0104 0.0104
Schistosoma mansoni syntrophin 0.0012 0.0104 0.0104
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.0012 0.0104 0.0104
Schistosoma mansoni hypothetical protein 0.0012 0.0104 0.0104
Echinococcus multilocularis Pleckstrin y 0.0012 0.0104 0.0104
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0023 0.0307 0.0307
Brugia malayi Uncoordinated protein 104 0.0012 0.0104 0.0104
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0023 0.0307 0.0307
Brugia malayi Cadps2 protein 0.0012 0.0104 0.0104
Echinococcus multilocularis pdz domain containing protein 0.0012 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0012 0.0104 0.0104
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0012 0.0113 0.0074
Brugia malayi Pleckstrin Homology Domain 0.0012 0.0104 0.0104
Onchocerca volvulus 0.0012 0.0104 0.5
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.0012 0.0104 0.0104
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0045 0.0698 0.0698
Echinococcus granulosus protein kinase c epsilon type 0.0023 0.0307 0.0307
Echinococcus granulosus Oxysterol binding protein 11 0.0012 0.0104 0.0104
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0012 0.0104 0.0104
Loa Loa (eye worm) syntrophin-1 0.0012 0.0104 0.0104
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0012 0.0113 0.0074
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.0012 0.0104 0.0104
Echinococcus multilocularis serine:threonine protein kinase N2 0.0023 0.0307 0.0307
Entamoeba histolytica protein kinase, putative 0.0023 0.0307 0.1676
Onchocerca volvulus 0.0012 0.0104 0.5
Entamoeba histolytica PH domain containing protein kinase, putative 0.0012 0.0113 0.0074
Onchocerca volvulus 0.0012 0.0104 0.5
Echinococcus multilocularis Oxysterol binding protein 11 0.0012 0.0104 0.0104
Brugia malayi Protein kinase domain containing protein 0.0023 0.0307 0.0307
Echinococcus multilocularis rac serine:threonine kinase 0.0056 0.0911 0.0911
Schistosoma mansoni centaurin alpha 0.0012 0.0104 0.0104
Trypanosoma brucei rac serine-threonine kinase, putative 0.0079 0.1317 1
Onchocerca volvulus outspread protein homolog 0.0012 0.0104 0.5
Brugia malayi Syntrophin-1 0.0012 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0012 0.0104 0.0104
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0012 0.0113 0.0111
Entamoeba histolytica PH domain containing protein kinase, putative 0.0056 0.0911 0.6647
Trichomonas vaginalis AGC family protein kinase 0.0012 0.0113 0.0074
Trichomonas vaginalis AGC family protein kinase 0.0012 0.0113 0.0074
Loa Loa (eye worm) hypothetical protein 0.0014 0.0152 0.0152
Trichomonas vaginalis AGC family protein kinase 0.0035 0.052 0.3427
Loa Loa (eye worm) AGC/NDR protein kinase 0.0023 0.0307 0.0307
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0012 0.0104 0.0104
Trichomonas vaginalis AGC family protein kinase 0.0079 0.1317 1
Brugia malayi Oxysterol-binding protein 0.0012 0.0104 0.0104
Schistosoma mansoni rho gtpase activating protein 0.0012 0.0104 0.0104
Echinococcus granulosus cytohesin 1 0.0202 0.3528 0.3528
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0012 0.0113 0.0074
Loa Loa (eye worm) hypothetical protein 0.0012 0.0104 0.0104
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0044 0.0689 0.0689
Leishmania major serine/threonine-protein kinase a, putative 0.0012 0.0113 1
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0307 0.0307
Trichomonas vaginalis protein transport protein sec7, putative 0.0014 0.0145 0.0339
Echinococcus multilocularis protein kinase c iota type 0.0023 0.0307 0.0307
Echinococcus multilocularis Ras associated and pleckstrin y 0.0012 0.0104 0.0104
Trichomonas vaginalis AGC family protein kinase 0.0012 0.0113 0.0074
Entamoeba histolytica protein kinase 2, putative 0.0045 0.0698 0.4896
Echinococcus granulosus myotubularin protein 13 0.0012 0.0104 0.0104
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.0012 0.0104 0.0104
Trichomonas vaginalis AGC family protein kinase 0.0012 0.0113 0.0074
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0012 0.0113 0.0151
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0307 0.0307
Echinococcus multilocularis nervana 2 0.0044 0.0689 0.0689
Brugia malayi p70 ribosomal S6 kinase beta 0.0067 0.1105 0.1105
Loa Loa (eye worm) AGC/PKN protein kinase 0.0023 0.0307 0.0307
Brugia malayi Plekhf2 protein 0.0012 0.0104 0.0104
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0012 0.0104 0.0104
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0014 0.0152 0.0152
Echinococcus multilocularis beta 1 syntrophin 0.0012 0.0104 0.0104
Brugia malayi Dynamin 0.0012 0.0104 0.0104
Echinococcus multilocularis serine:threonine protein kinase 38 0.0023 0.0307 0.0307
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0307 0.0307
Echinococcus multilocularis serine threonine protein kinase 0.0023 0.0307 0.0307
Schistosoma mansoni atypical protein kinase C 0.0023 0.0307 0.0307
Trichomonas vaginalis AGC family protein kinase 0.0012 0.0113 0.0074
Brugia malayi protein kinase C II. 0.0023 0.0307 0.0307
Schistosoma mansoni growth factor receptor-bound protein 0.0012 0.0104 0.0104
Onchocerca volvulus Abnormal cell migration protein 10 homolog 0.0012 0.0104 0.5
Echinococcus granulosus protein kinase c iota type 0.0023 0.0307 0.0307
Loa Loa (eye worm) hypothetical protein 0.0012 0.0104 0.0104
Onchocerca volvulus 0.0012 0.0104 0.5
Plasmodium falciparum calcium-dependent protein kinase 7 0.0012 0.0113 0.0151
Brugia malayi PH domain containing protein 0.0012 0.0104 0.0104
Entamoeba histolytica protein kinase, putative 0.0012 0.0113 0.0074
Loa Loa (eye worm) hypothetical protein 0.0012 0.0104 0.0104
Echinococcus multilocularis myotubularin protein 13 0.0012 0.0104 0.0104
Schistosoma mansoni serine/threonine-protein kinase 0.0056 0.0911 0.0911
Echinococcus granulosus indoleamine 23 dioxygenase 2 0.056 1 1
Loa Loa (eye worm) AGC/AKT protein kinase 0.0079 0.1317 0.1317
Entamoeba histolytica PH domain containing protein kinase, putative 0.0056 0.0911 0.6647
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0045 0.0698 0.7366
Schistosoma mansoni hypothetical protein 0.056 1 1
Trypanosoma cruzi Protein kinase B 0.0056 0.0911 1
Echinococcus granulosus serine threonine protein kinase nrc 0.0045 0.0698 0.0698
Echinococcus multilocularis serine:threonine protein kinase N2 0.0023 0.0307 0.0307
Trypanosoma cruzi NIMA-related kinase, putative 0.0012 0.0113 0.0111
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.0012 0.0104 0.0104
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0012 0.0104 0.0104
Trichomonas vaginalis AGC family protein kinase 0.0012 0.0113 0.0074
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0012 0.0113 0.0074
Entamoeba histolytica hypothetical protein 0.0014 0.0151 0.0386
Entamoeba histolytica p21-activated kinase 0.0012 0.0113 0.0074
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0202 0.3528 0.3528
Trichomonas vaginalis AGC family protein kinase 0.0079 0.1317 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0104 0.0104
Brugia malayi probable spectrin beta chain 0.0012 0.0104 0.0104
Loa Loa (eye worm) cytohesin 3 0.0202 0.3528 0.3528
Loa Loa (eye worm) indoleamine 2,3-dioxygenase 0.056 1 1
Echinococcus multilocularis indoleamine 2,3 dioxygenase 2 0.056 1 1
Trichomonas vaginalis AGC family protein kinase 0.0023 0.0307 0.1676
Trichomonas vaginalis AGC family protein kinase 0.0012 0.0113 0.0074
Schistosoma mansoni rhogef and pleckstrin domain protein 0.0012 0.0104 0.0104
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.0012 0.0104 0.0104
Trichomonas vaginalis AGC family protein kinase 0.0012 0.0113 0.0074
Schistosoma mansoni hypothetical protein 0.0012 0.0104 0.0104
Entamoeba histolytica PH domain containing protein kinase, putative 0.0012 0.0113 0.0074
Echinococcus multilocularis dynamin 1 0.0012 0.0104 0.0104
Loa Loa (eye worm) Plekhf2 protein 0.0012 0.0104 0.0104
Onchocerca volvulus Putative neuronal RhoA GEF protein 0.0012 0.0104 0.5
Echinococcus granulosus pdz domain containing protein 0.0012 0.0104 0.0104
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0012 0.0113 0.0111
Echinococcus granulosus pleckstrin y domain containing family A 0.0012 0.0104 0.0104
Schistosoma mansoni goodpasture antigen-binding protein 0.0012 0.0104 0.0104
Brugia malayi Dynamin 0.0012 0.0104 0.0104
Echinococcus granulosus oxysterol binding protein 9 0.0012 0.0104 0.0104
Brugia malayi TBC domain containing protein 0.0012 0.0104 0.0104
Brugia malayi PH domain containing protein 0.0012 0.0104 0.0104
Trichomonas vaginalis AGC family protein kinase 0.0012 0.0113 0.0074
Entamoeba histolytica protein kinase, putative 0.0067 0.1105 0.8249
Loa Loa (eye worm) hypothetical protein 0.0012 0.0104 0.0104
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0012 0.0113 0.0111
Echinococcus multilocularis calcium dependent secretion activator 1 0.0012 0.0104 0.0104
Schistosoma mansoni serine/threonine kinase 0.0023 0.0307 0.0307
Echinococcus granulosus Pleckstrin y 0.0012 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0023 0.0307 0.0307
Echinococcus granulosus protein kinase C gamma type 0.0023 0.0307 0.0307
Trypanosoma brucei protein kinase, putative 0.0012 0.0113 0.0074
Giardia lamblia Kinase, AGC PKA 0.0045 0.0698 0.5
Schistosoma mansoni oxysterol-binding protein 1 0.0012 0.0104 0.0104
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0307 0.0307
Entamoeba histolytica protein kinase, putative 0.0079 0.1317 1
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0045 0.0698 0.0698
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0012 0.0113 0.009
Onchocerca volvulus 0.0012 0.0104 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0307 0.0307
Echinococcus multilocularis Glutaredoxin protein 5 0.0044 0.0689 0.0689
Loa Loa (eye worm) hypothetical protein 0.0012 0.0104 0.0104
Trichomonas vaginalis AGC family protein kinase 0.0012 0.0113 0.0074
Loa Loa (eye worm) hypothetical protein 0.0012 0.0104 0.0104
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0012 0.0113 0.0111
Brugia malayi Protein kinase domain containing protein 0.0079 0.1317 0.1317
Trichomonas vaginalis AGC family protein kinase 0.0012 0.0113 0.0074
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0307 0.0307
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0023 0.0298 0.1602
Echinococcus granulosus NDR protein kinase 0.0023 0.0307 0.0307
Schistosoma mansoni dynamin 0.0012 0.0104 0.0104
Brugia malayi PH domain containing protein 0.0012 0.0104 0.0104
Brugia malayi Cytohesin 3 0.0202 0.3528 0.3528
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0012 0.0113 0.0111
Onchocerca volvulus 0.0012 0.0104 0.5
Trichomonas vaginalis protein transport protein sec7, putative 0.0014 0.0145 0.0339
Schistosoma mansoni hypothetical protein 0.0012 0.0104 0.0104
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0056 0.0911 1
Entamoeba histolytica protein kinase, putative 0.0012 0.0113 0.0074
Leishmania major protein kinase, putative 0.0012 0.0113 1
Entamoeba histolytica hypothetical protein 0.0012 0.0113 0.0074
Brugia malayi Hr1 repeat family protein 0.0023 0.0307 0.0307
Echinococcus multilocularis DCC interacting protein 13 beta 0.0012 0.0104 0.0104
Leishmania major protein kinase, putative 0.0012 0.0113 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0104 0.0104
Schistosoma mansoni serine/threonine-protein kinase 0.0056 0.0911 0.0911

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.