Detailed information for compound 1782986

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 497.852 | Formula: C24H24N4O4Zn
  • H donors: 4 H acceptors: 6 LogP: 1.43 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCc1cnc(c(c1/C=N/c1cc(C)c(cc1/N=C/c1c(C[O-])cnc(c1O)C)C)[O-])C.[Zn+2]
  • InChi: 1S/C24H25N4O4.Zn/c1-13-5-21(27-9-19-17(11-29)7-25-15(3)23(19)31)22(6-14(13)2)28-10-20-18(12-30)8-26-16(4)24(20)32;/h5-10,29,31-32H,11-12H2,1-4H3;/q-1;+2/p-1/b27-9+,28-10+;
  • InChiKey: VRTPCGKOASEXHN-VFOBFDCPSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 10 Starlite/ChEMBL No references
Homo sapiens hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) Starlite/ChEMBL No references
Homo sapiens arachidonate 15-lipoxygenase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Brugia malayi hypothetical protein Get druggable targets OG5_131074 All targets in OG5_131074
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Cryptosporidium parvum scully CG7113-PA, putative Get druggable targets OG5_129031 All targets in OG5_129031
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131074 All targets in OG5_131074
Cryptosporidium hominis scully CG7113-PA Get druggable targets OG5_129031 All targets in OG5_129031
Brugia malayi hypoxia-induced factor 1 Get druggable targets OG5_131074 All targets in OG5_131074
Schistosoma japonicum ko:K00022 3-hydroxyacyl-CoA dehydrogenase [EC1.1.1.35], putative Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania donovani 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania infantum 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania mexicana 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase Get druggable targets OG5_129031 All targets in OG5_129031
Loa Loa (eye worm) hypoxia-induced factor 1 Get druggable targets OG5_131074 All targets in OG5_131074
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania braziliensis 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus arachidonate 5 lipoxygenase arachidonate 15-lipoxygenase 662 aa 590 aa 23.9 %
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase hydroxysteroid (17-beta) dehydrogenase 10 252 aa 251 aa 24.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis neuropeptide s receptor 0.0017 0.0097 0.0097
Schistosoma mansoni aminopeptidase A (M01 family) 0.0036 0.0342 0.0363
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0016 0.0017
Brugia malayi Tachykinin-like peptides receptor 99D 0.0017 0.0097 0.0103
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0068 0.0756 0.0803
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0103
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0096 0.0027
Echinococcus multilocularis protein patched 0.0041 0.0401 0.0401
Schistosoma mansoni cpg binding protein 0.0028 0.0232 0.0247
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0015 0.0071 0.0067
Schistosoma mansoni hypothetical protein 0.0035 0.0323 0.0343
Onchocerca volvulus 0.0029 0.0254 0.027
Brugia malayi hypothetical protein 0.0017 0.0097 0.0103
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0015 0.0071 0.0067
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0737 0.9406 1
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0012 0.0023 0.0025
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0036 0.0342 0.0363
Toxoplasma gondii hypothetical protein 0.0012 0.0023 0.0014
Onchocerca volvulus 0.0017 0.0097 0.0103
Echinococcus granulosus serotonin receptor 0.0017 0.0097 0.0103
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0268 0.3339 0.355
Echinococcus granulosus fmrfamide receptor 0.0017 0.0097 0.0103
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0153 0.0154
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0012 0.0023 0.0025
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0012 0.0023 0.0014
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0103 0.1204 0.128
Brugia malayi putative neuropeptide receptor NPR1 0.0017 0.0097 0.0103
Brugia malayi hypothetical protein 0.0046 0.0469 0.0499
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0135 0.0144
Echinococcus granulosus dro:myosuppressin receptor 0.0017 0.0097 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0071 0.0067
Brugia malayi Cathepsin L-like precursor 0.002 0.0135 0.0144
Brugia malayi hypothetical protein 0.0017 0.0097 0.0103
Plasmodium vivax RNA helicase-1, putative 0.0737 0.9406 1
Brugia malayi hypothetical protein 0.0017 0.0097 0.0103
Schistosoma mansoni alpha-1 adrenergic receptor 0.0017 0.0097 0.0103
Echinococcus granulosus biogenic amine 5HT receptor 0.0155 0.1873 0.1992
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0135 0.0135
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0016 0.0008
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0097 0.0103
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0017 0.0097 0.0097
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0737 0.9406 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.017 0.0093
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.087 0.0916
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0012 0.0023 0.0023
Echinococcus multilocularis musashi 0.0029 0.0254 0.0254
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0012 0.0023 0.0025
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0022 0.0153 0.0163
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0135 0.0135
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0067 0.0736 0.0782
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0135 0.0135
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0015 0.0071 0.6663
Loa Loa (eye worm) hypothetical protein 0.0036 0.0342 0.0363
Echinococcus granulosus allatostatin A receptor 0.0017 0.0097 0.0103
Echinococcus multilocularis expressed conserved protein 0.0089 0.1029 0.1029
Echinococcus multilocularis ETS transcription factor Elf 5 0.0011 0.0022 0.0022
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0737 0.9406 1
Plasmodium falciparum eukaryotic initiation factor 4A 0.0737 0.9406 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.1122 0.1193
Brugia malayi Melatonin receptor type 1A 0.0017 0.0097 0.0103
Brugia malayi Doublecortin family protein 0.0046 0.0469 0.0499
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0103 0.1204 0.1214
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0008 0.0009
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0103
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.017 0.0172
Loa Loa (eye worm) hypothetical protein 0.0036 0.0342 0.0363
Brugia malayi hypothetical protein 0.0197 0.2421 0.2574
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0036 0.0342 0.0355
Schistosoma mansoni rab6-interacting 0.0046 0.0469 0.0499
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0096 0.0096
Mycobacterium ulcerans hypothetical protein 0.0023 0.017 0.0675
Echinococcus multilocularis sodium and chloride dependent glycine 0.0012 0.0023 0.0023
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0769 0.6078
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0103
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0017 0.0097 0.0097
Schistosoma mansoni ap endonuclease 0.0021 0.0139 0.0148
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.087 0.0916
Loa Loa (eye worm) peptidase family M1 containing protein 0.0201 0.2468 0.2624
Echinococcus granulosus serotonin transporter 0.0068 0.0756 0.0803
Loa Loa (eye worm) ctsf protein 0.002 0.0135 0.0144
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0135 0.0144
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0103
Onchocerca volvulus 0.0046 0.0469 0.0499
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0323 0.0343
Echinococcus granulosus cathepsin L cysteine protease 0.001 0.0008 0.0009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.087 0.0916
Onchocerca volvulus 0.0017 0.0097 0.0103
Schistosoma mansoni hypothetical protein 0.0046 0.0469 0.0499
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0012 0.0023 0.0023
Entamoeba histolytica aminopeptidase, putative 0.0103 0.1204 0.1273
Loa Loa (eye worm) hypoxia-induced factor 1 0.0182 0.2224 0.2364
Brugia malayi hypothetical protein 0.0103 0.1204 0.128
Loa Loa (eye worm) hypothetical protein 0.0012 0.0023 0.0025
Echinococcus granulosus sodium and chloride dependent glycine 0.0012 0.0023 0.0025
Loa Loa (eye worm) hypothetical protein 0.0033 0.0299 0.0318
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0036 0.0342 0.029
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0103
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0153 0.0154
Brugia malayi PAS domain containing protein 0.0059 0.0633 0.0673
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0023 0.0016
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.087 0.0916
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0737 0.9406 1
Schistosoma mansoni intermediate filament proteins 0.0029 0.0254 0.027
Brugia malayi AKH receptor 0.0017 0.0097 0.0103
Onchocerca volvulus 0.0017 0.0097 0.0103
Brugia malayi eukaryotic initiation factor 4A 0.0737 0.9406 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0103
Loa Loa (eye worm) hypothetical protein 0.0014 0.0049 0.0052
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0071 0.0075
Echinococcus multilocularis serotonin receptor 0.0155 0.1873 0.1873
Echinococcus multilocularis cpg binding protein 0.0029 0.0253 0.0253
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0769 0.0769
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0.0097 0.0097
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0011 0.0016 0.0008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.087 0.0916
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0022 0.0153 0.0153
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.017 0.0675
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.0097 0.0103
Echinococcus multilocularis aryl hydrocarbon receptor 0.0015 0.0071 0.0071
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0139 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0135 0.0135
Schistosoma mansoni lamin 0.0029 0.0254 0.027
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0232 0.0247
Schistosoma mansoni amine GPCR 0.0017 0.0097 0.0103
Trypanosoma brucei Aminopeptidase M1, putative 0.0103 0.1204 0.1273
Echinococcus granulosus cathepsin l1 0.002 0.0135 0.0144
Brugia malayi hypothetical protein 0.0017 0.0097 0.0103
Echinococcus multilocularis cysteine protease 0.002 0.0135 0.0135
Echinococcus granulosus orexin receptor type 2 0.0017 0.0097 0.0103
Echinococcus multilocularis muscleblind protein 1 0.0144 0.1739 0.1739
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0737 0.9406 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0023 0.0025
Echinococcus granulosus sodium and chloride dependent glycine 0.0012 0.0023 0.0025
Leishmania major cathepsin L-like protease 0.002 0.0135 0.0069
Echinococcus granulosus neuropeptide s receptor 0.0017 0.0097 0.0103
Schistosoma mansoni neuropeptide receptor 0.0017 0.0097 0.0103
Onchocerca volvulus 0.002 0.0135 0.0144
Onchocerca volvulus 0.0017 0.0097 0.0103
Brugia malayi AMP-binding enzyme family protein 0.0023 0.017 0.0181
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0103
Echinococcus granulosus lipoxygenase domain containing protein 0.0046 0.0469 0.0499
Trypanosoma brucei aminopeptidase, putative 0.0036 0.0342 0.0355
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0135 0.0135
Leishmania major eukaryotic initiation factor 4a, putative 0.0737 0.9406 1
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0036 0.0342 0.0355
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0012 0.0023 0.0025
Brugia malayi Niemann-Pick C1 protein precursor 0.0095 0.1103 0.1173
Echinococcus granulosus Niemann Pick C1 protein 0.0095 0.1103 0.1173
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.087 0.0916
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0769 0.0818
Brugia malayi TATA binding protein associated factor 0.0036 0.0342 0.0363
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0017 0.0097 0.0103
Echinococcus multilocularis neuropeptide Y receptor 0.0017 0.0097 0.0097
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0017 0.0097 0.0097
Echinococcus multilocularis aminopeptidase N 0.0267 0.3331 0.3331
Leishmania major cathepsin L-like protease 0.002 0.0135 0.0069
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0022 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0155 0.1873 0.1992
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0097 0.0097
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0135 0.0135
Echinococcus granulosus neuropeptide receptor 0.0017 0.0097 0.0103
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0103
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0135 0.0144
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0012 0.0023 0.0025
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0017 0.0097 0.0103
Echinococcus granulosus g protein coupled receptor 0.0017 0.0097 0.0103
Onchocerca volvulus 0.0012 0.0023 0.0025
Onchocerca volvulus 0.0017 0.0097 0.0103
Trypanosoma cruzi Aminopeptidase M1, putative 0.0103 0.1204 0.1273
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0135 0.0135
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0071 0.0075
Onchocerca volvulus 0.0017 0.0097 0.0103
Trichomonas vaginalis guanylate cyclase, putative 0.0015 0.0071 0.0067
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0017 0.0097 0.0097
Onchocerca volvulus 0.0017 0.0097 0.0103
Echinococcus granulosus neuropeptide Y receptor 0.0017 0.0097 0.0103
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0017 0.0097 0.0103
Brugia malayi neuropeptide F receptor 0.0017 0.0097 0.0103
Echinococcus multilocularis cathepsin L 0.001 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0039 0.0382 0.0407
Echinococcus granulosus neuropeptide Y receptor 0.0017 0.0097 0.0103
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0036 0.0342 0.0363
Onchocerca volvulus 0.0017 0.0097 0.0103
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0017 0.0097 0.0097
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0012 0.0023 0.0025
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.017 1
Schistosoma mansoni hypothetical protein 0.0011 0.0022 0.0023
Entamoeba histolytica cysteine protease, putative 0.002 0.0135 0.0135
Echinococcus multilocularis neuropeptide receptor 0.0017 0.0097 0.0097
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0135 0.0135
Echinococcus multilocularis protein C ets 2 0.0011 0.0022 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0014 0.0057 0.0061
Schistosoma mansoni neuropeptide receptor 0.0017 0.0097 0.0103
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0139 0.0139
Brugia malayi CXXC zinc finger family protein 0.0028 0.0232 0.0247
Loa Loa (eye worm) hypothetical protein 0.0023 0.017 0.0181
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0135 0.0135
Schistosoma mansoni hypothetical protein 0.0015 0.0071 0.0075
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.017 0.0675
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.087 0.0916
Loa Loa (eye worm) fibroinase 0.002 0.0135 0.0144
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0103 0.1204 0.1204
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0135 0.0135
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0103
Echinococcus granulosus neuropeptides capa receptor 0.0017 0.0097 0.0103
Echinococcus multilocularis Polycystic kidney disease protein 0.0046 0.0469 0.0469
Echinococcus granulosus dnaJ subfamily B 0.0395 0.4982 0.5296
Loa Loa (eye worm) neuropeptide F receptor 0.0017 0.0097 0.0103
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0103 0.1204 0.128
Leishmania major cathepsin L-like protease 0.0077 0.087 0.0855
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.017 0.0093
Leishmania major eukaryotic initiation factor 4a, putative 0.0737 0.9406 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0139 0.0139
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.0097 0.0103
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0135 0.0135
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0008 0.0009
Echinococcus multilocularis G-protein coupled receptor, putative 0.0017 0.0097 0.0097
Schistosoma mansoni sodium-dependent amino acid transporter 0.0012 0.0023 0.0025
Onchocerca volvulus 0.0017 0.0097 0.0103
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0017 0.0097 0.0103
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0022 0.0153 0.0163
Loa Loa (eye worm) serotonin transporter b 0.0068 0.0756 0.0803
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0015 0.0071 0.0067
Echinococcus multilocularis ets variant gene 4 0.0011 0.0022 0.0022
Loa Loa (eye worm) TATA binding protein associated factor 0.0036 0.0342 0.0363
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0737 0.9406 0.9406
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0103
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0103
Treponema pallidum ATP-dependent RNA helicase 0.0737 0.9406 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0017 0.0097 0.0097
Schistosoma mansoni ets-related 0.0011 0.0022 0.0023
Schistosoma mansoni elf1 0.0011 0.0022 0.0023
Schistosoma mansoni biogenic amine receptor 0.0017 0.0097 0.0103
Brugia malayi Cathepsin L-like precursor 0.002 0.0135 0.0144
Schistosoma mansoni biogenic amine receptor 0.0017 0.0097 0.0103
Schistosoma mansoni ets-related 0.024 0.2973 0.316
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0103
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0015 0.0071 0.0071
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0014 0.005 0.0053
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0101
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0017 0.0097 0.0103
Schistosoma mansoni neuropeptide receptor 0.0017 0.0097 0.0103
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0103 0.1204 0.1204
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0139 0.0139
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.087 0.0916
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0135 0.0135
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0071 0.0075
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0012 0.0023 0.0025
Echinococcus multilocularis muscleblind protein 0.0144 0.1739 0.1739
Loa Loa (eye worm) hypothetical protein 0.0014 0.0049 0.0052
Brugia malayi Cathepsin L-like precursor 0.002 0.0135 0.0144
Schistosoma mansoni cpg binding protein 0.0029 0.0253 0.0269
Onchocerca volvulus 0.0267 0.3331 0.3541
Echinococcus multilocularis neuropeptide Y receptor 0.0017 0.0097 0.0097
Loa Loa (eye worm) G-protein coupled receptor 0.0017 0.0097 0.0103
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0103
Brugia malayi G-protein coupled receptor 0.0017 0.0097 0.0103
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0096 0.0091
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0.0097 0.0103
Echinococcus granulosus cathepsin l1 0.0014 0.0049 0.0052
Toxoplasma gondii aminopeptidase n, putative 0.0036 0.0342 0.0352
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0067 0.0737 0.0775
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0097 0.0103
Echinococcus granulosus aryl hydrocarbon receptor 0.0015 0.0071 0.0076
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0017
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0012 0.0023 0.0025
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0096 0.0096
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0401 0.0418
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0139 0.0131
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0036 0.0342 0.0355
Loa Loa (eye worm) hypothetical protein 0.0048 0.0496 0.0528
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0135 0.0135
Onchocerca volvulus 0.002 0.0135 0.0144
Brugia malayi G protein-coupled receptor 0.0017 0.0097 0.0103
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0095 0.1103 0.1165
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0015 0.0071 0.0067
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0012 0.0023 0.0025
Schistosoma mansoni hypothetical protein 0.0017 0.0097 0.0103
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0103
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0737 0.9406 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0057 0.0057
Echinococcus multilocularis neuropeptides capa receptor 0.0017 0.0097 0.0097
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0036 0.0342 0.0355
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0096 0.0094
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0017 0.0097 0.0097
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0097 0.0103
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.017 0.0675
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.017 0.0675
Loa Loa (eye worm) D-ets-2 protein 0.0011 0.0022 0.0023
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0103 0.1204 0.1273
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0071 0.0075
Echinococcus multilocularis dnaJ subfamily B 0.0395 0.4982 0.4982
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0656 0.069
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0017 0.0097 0.0103
Schistosoma mansoni neuropeptide f receptor 76f 0.0017 0.0097 0.0103
Onchocerca volvulus 0.0017 0.0097 0.0103
Echinococcus granulosus ewsr:fli fusion protein type 0.0011 0.0022 0.0023
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0135 0.0144
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0097 0.0097
Brugia malayi transcription factor E74 isoform 0.0011 0.0022 0.0023
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0071 0.0071
Plasmodium falciparum LCCL domain-containing protein 0.0046 0.0469 0.049
Echinococcus multilocularis fmrfamide receptor 0.0017 0.0097 0.0097
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0496 0.0528
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.017 0.0106
Brugia malayi hypothetical protein 0.0046 0.0469 0.0499
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0036 0.0342 0.0355
Echinococcus granulosus tachykinin peptides receptor 99D 0.0017 0.0097 0.0103
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0036 0.0342 0.0355
Echinococcus multilocularis allatostatin A receptor 0.0017 0.0097 0.0097
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0153 0.0088
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.087 0.0916
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0097 0.0103
Plasmodium falciparum amino acid transporter, putative 0.0012 0.0023 0.0016
Loa Loa (eye worm) hypothetical protein 0.0068 0.0746 0.0794
Schistosoma mansoni histamine h1 receptor 0.0017 0.0097 0.0103
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0153 0.0153
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0097 0.0103
Entamoeba histolytica cysteine proteinase, putative 0.0014 0.0049 0.0043
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0103 0.1204 0.1273
Loa Loa (eye worm) doublecortin family protein 0.0046 0.0469 0.0499
Schistosoma mansoni hypothetical protein 0.0015 0.0071 0.0075
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0015 0.0071 0.0076
Echinococcus granulosus alpha 1A adrenergic receptor 0.0017 0.0097 0.0103
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.087 0.0916
Schistosoma mansoni neuropeptide F-like receptor 0.0017 0.0097 0.0103
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0254 0.027
Schistosoma mansoni ap endonuclease 0.0021 0.0139 0.0148
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0737 0.9406 1
Onchocerca volvulus 0.0029 0.0254 0.027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0135 0.0135
Echinococcus granulosus ETS transcription factor Elf 1 0.0011 0.0022 0.0023
Schistosoma mansoni sodium/chloride dependent transporter 0.0012 0.0023 0.0025
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0103 0.1204 0.128
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0103 0.1204 0.128
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0153 0.0163
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0011 0.0022 0.0023
Loa Loa (eye worm) aminopeptidase N 0.0103 0.1204 0.128
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0737 0.9406 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0165 0.2 0.2127
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0103 0.1204 0.1204
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0015 0.0071 0.0067
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0069 0.0769 0.0748
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0135 0.0135
Schistosoma mansoni patched 1 0.0041 0.0401 0.0427
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0022 0.0153 0.0154
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0069 0.0769 0.0818
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0012 0.0023 0.0023
Brugia malayi intermediate filament protein 0.0029 0.0254 0.027
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0153 0.0163
Schistosoma mansoni amine GPCR 0.0017 0.0097 0.0103
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0067 0.0736 0.0736
Brugia malayi Peptidase family M1 containing protein 0.0103 0.1204 0.128
Schistosoma mansoni loxhd1 0.0046 0.0469 0.0499
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0101
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0103
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0017 0.0097 0.0103
Plasmodium vivax multidomain scavenger receptor, putative 0.0046 0.0469 0.049
Echinococcus multilocularis neuropeptides capa receptor 0.0017 0.0097 0.0097
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0103 0.1204 0.1204
Echinococcus multilocularis ETS transcription factor Elf 1 0.0011 0.0022 0.0022
Echinococcus multilocularis Niemann Pick C1 protein 0.0136 0.1631 0.1631
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0067 0.0737 0.0783
Brugia malayi DNA-binding protein D-ETS-3 0.0011 0.0022 0.0023
Loa Loa (eye worm) hypothetical protein 0.005 0.052 0.0553
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0153 0.0154
Onchocerca volvulus 0.0017 0.0097 0.0103
Entamoeba histolytica recQ family DNA helicase 0.0011 0.0016 0.0008
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0135 0.0135
Onchocerca volvulus 0.002 0.0135 0.0144
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0103
Onchocerca volvulus 0.0017 0.0097 0.0103
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0135 0.0144
Onchocerca volvulus 0.0017 0.0097 0.0103
Echinococcus multilocularis RUN 0.0046 0.0469 0.0469
Trypanosoma cruzi aminopeptidase, putative 0.0036 0.0342 0.0355
Onchocerca volvulus Cathepsin L homolog 0.002 0.0135 0.0144
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0071 0.0067
Echinococcus granulosus neuropeptide receptor 0.0017 0.0097 0.0103
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0011 0.0022 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0135 0.0135
Echinococcus granulosus g-protein coupled receptor 0.0017 0.0097 0.0103
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0103
Echinococcus multilocularis g protein coupled receptor 0.0017 0.0097 0.0097
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0103 0.1204 0.1204
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0737 0.9406 1
Echinococcus granulosus lamin dm0 0.0029 0.0254 0.027
Brugia malayi Serotonin receptor 0.0017 0.0097 0.0103
Onchocerca volvulus 0.0017 0.0097 0.0103
Schistosoma mansoni opsin-like receptor 0.0017 0.0097 0.0103
Brugia malayi Cathepsin L-like cysteine proteinase 0.0014 0.0049 0.0052
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0103
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0011 0.0022 0.0023
Loa Loa (eye worm) hypothetical protein 0.0012 0.0023 0.0025
Onchocerca volvulus 0.0017 0.0097 0.0103
Brugia malayi isocitrate dehydrogenase 0.0017 0.0096 0.0103
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0015 0.0071 0.0076
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0096 0.0094
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0012 0.0023 0.0025
Echinococcus granulosus g protein coupled receptor 0.0017 0.0097 0.0103
Schistosoma mansoni lipoxygenase 0.0067 0.0736 0.0782
Loa Loa (eye worm) hypothetical protein 0.0737 0.9406 1
Echinococcus multilocularis g protein coupled receptor 0.0017 0.0097 0.0097
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0139 0.006
Echinococcus granulosus sex peptide receptor 0.0017 0.0097 0.0103
Onchocerca volvulus 0.0017 0.0097 0.0103
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0012 0.0023 0.0025
Loa Loa (eye worm) hypothetical protein 0.0011 0.0022 0.0023
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.017 0.0172
Leishmania major cathepsin L-like protease 0.0077 0.087 0.0855
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0017 0.0097 0.0103
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0401 0.0427
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0.0097 0.0103
Loa Loa (eye worm) hypothetical protein 0.0022 0.0153 0.0163
Loa Loa (eye worm) neuropeptide F receptor 0.0017 0.0097 0.0103
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0017 0.0097 0.0103
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0011 0.0011 0.0002
Echinococcus granulosus lamin 0.0029 0.0254 0.027
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0011 0.0022 0.0023
Brugia malayi hypoxia-induced factor 1 0.0182 0.2224 0.2364
Echinococcus granulosus GPCR family 2 0.0015 0.0071 0.0075
Toxoplasma gondii exonuclease III APE 0.0021 0.0139 0.0136
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0017 0.0097 0.0103
Loa Loa (eye worm) hypothetical protein 0.0095 0.1103 0.1173
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0097 0.0103
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0096 0.0094
Loa Loa (eye worm) hypothetical protein 0.0023 0.017 0.0181
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0068 0.0756 0.0803
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0069 0.0769 0.0736
Plasmodium vivax vivapain-2 0.002 0.0135 0.0135
Brugia malayi bHLH-PAS transcription factor 0.0043 0.0436 0.0463
Brugia malayi hypothetical protein 0.0017 0.0097 0.0103
Loa Loa (eye worm) hypothetical protein 0.0068 0.0756 0.0803
Echinococcus multilocularis serotonin receptor 0.0155 0.1873 0.1873
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0036 0.0342 0.0363
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0496 0.0528
Echinococcus granulosus neuropeptides capa receptor 0.0017 0.0097 0.0103
Onchocerca volvulus 0.0036 0.0342 0.0363
Schistosoma mansoni neuropeptide F-like receptor 0.0017 0.0097 0.0103
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0017 0.0097 0.0097
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0015 0.0071 0.0067
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0097 0.0103
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0135 0.0135
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.087 0.0916
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0095 0.0092
Loa Loa (eye worm) hypothetical protein 0.0068 0.0756 0.0803
Echinococcus multilocularis lamin 0.0029 0.0254 0.0254
Schistosoma mansoni cathepsin F (C01 family) 0.0014 0.0049 0.0052
Echinococcus granulosus hypothetical protein 0.0017 0.0097 0.0103
Schistosoma mansoni hypothetical protein 0.0039 0.0382 0.0407
Mycobacterium ulcerans aminopeptidase N PepN 0.0036 0.0342 0.2223
Echinococcus granulosus somatostatin receptor 0.0017 0.0097 0.0103
Treponema pallidum sodium- and chloride- dependent transporter 0.0068 0.0756 0.0787
Echinococcus multilocularis GPCR, family 2 0.0015 0.0071 0.0071
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0029 0.0254 0.027
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0012 0.0023 0.0025
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0012 0.0023 0.0025
Schistosoma mansoni opsin-like receptor 0.0017 0.0097 0.0103
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0401 0.0427
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0017 0.0097 0.0097
Brugia malayi larval opioid receptor 0.0017 0.0097 0.0103
Schistosoma mansoni lipoxygenase 0.0046 0.0469 0.0499
Brugia malayi Ets-domain containing protein 0.0079 0.0894 0.0951
Echinococcus multilocularis fmrfamide receptor 0.0017 0.0097 0.0097
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0135 0.0135
Echinococcus granulosus peptide allatostatin:somatostatin 0.0017 0.0097 0.0103
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0103
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0017 0.0097 0.0103
Loa Loa (eye worm) RecQ helicase 0.0022 0.0153 0.0163
Echinococcus granulosus 7TM GPCR rhodopsin 0.0017 0.0097 0.0103
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0008 0.0009
Echinococcus granulosus Polycystic kidney disease protein 0.0046 0.0469 0.0499
Loa Loa (eye worm) hypothetical protein 0.0046 0.0469 0.0499
Onchocerca volvulus Cathepsin F homolog 0.002 0.0135 0.0144
Echinococcus granulosus eukaryotic initiation factor 4A 0.0737 0.9406 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0096 0.0096
Echinococcus granulosus ETS domain containing protein Elk 1 0.0011 0.0022 0.0023
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0103
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0135 0.0135
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0135 0.0135
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0096 0.0096
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0012 0.0023 0.0025
Echinococcus multilocularis lipoxygenase domain containing protein 0.0046 0.0469 0.0469
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0017 0.0097 0.0103
Onchocerca volvulus 0.0014 0.0049 0.0052
Brugia malayi Cathepsin L-like precursor 0.0014 0.0049 0.0052
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0.0097 0.0103
Onchocerca volvulus 0.002 0.0135 0.0144
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0103
Onchocerca volvulus Neuropeptide F receptor homolog 0.0017 0.0097 0.0103
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0036 0.0342 0.0363
Brugia malayi Dopamine receptor protein 2 0.0017 0.0097 0.0103
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0015 0.0071 0.0067
Entamoeba histolytica hypothetical protein 0.0035 0.0323 0.0335
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0103 0.1204 0.128
Loa Loa (eye worm) hypothetical protein 0.0067 0.0737 0.0783
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0103
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0103
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0135 0.0135
Schistosoma mansoni rab6-interacting 0.0046 0.0469 0.0499
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0737 0.9406 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0011 0.0011
Mycobacterium ulcerans putative regulatory protein 0.0043 0.0436 0.3072
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0103
Entamoeba histolytica hypothetical protein 0.0035 0.0323 0.0335
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0097 0.0103
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0103
Echinococcus granulosus leukotriene A 4 hydrolase 0.0036 0.0342 0.0363
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0139 0.0395
Brugia malayi hypothetical protein 0.0036 0.0342 0.0363
Echinococcus granulosus GA binding protein alpha chain 0.0079 0.0894 0.0951
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0071 0.0067
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.087 0.0916
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0096 0.0103
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0096 0.0091
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0135 0.0135
Brugia malayi cathepsin L-like precursor 0.0014 0.0049 0.0052
Onchocerca volvulus 0.0043 0.0436 0.0463
Echinococcus granulosus Niemann Pick C1 protein 0.0136 0.1631 0.1734
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0103
Loa Loa (eye worm) hypothetical protein 0.0144 0.1739 0.1849
Echinococcus multilocularis neuropeptide FF receptor 2 0.0017 0.0097 0.0097
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0153 0.0163
Loa Loa (eye worm) hypothetical protein 0.0012 0.0023 0.0025
Schistosoma mansoni amine GPCR 0.0017 0.0097 0.0103
Schistosoma mansoni sodium/chloride dependent transporter 0.0068 0.0756 0.0803
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.087 0.0916
Onchocerca volvulus 0.0015 0.0071 0.0076
Loa Loa (eye worm) norepinephrine transporter 0.0068 0.0756 0.0803
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0097 0.0103
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0101
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0096 0.0015
Loa Loa (eye worm) hypothetical protein 0.0046 0.0469 0.0499
Loa Loa (eye worm) melatonin receptor type 1A 0.0017 0.0097 0.0103
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0103 0.1204 0.1204
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0022 0.0023
Schistosoma mansoni adenoreceptor 0.0017 0.0097 0.0103
Echinococcus multilocularis neuropeptide receptor A26 0.0017 0.0097 0.0097
Brugia malayi ORL1-like opioid receptor 0.0017 0.0097 0.0103
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0095 1
Onchocerca volvulus 0.0011 0.0021 0.0022
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0096 0.0094
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.017 0.0675
Trypanosoma brucei Aminopeptidase M1, putative 0.0103 0.1204 0.1273
Brugia malayi CHE-14 protein 0.0041 0.0401 0.0427
Echinococcus multilocularis transfer RNA-Lys 0.0043 0.0436 0.0436
Schistosoma mansoni myosin xvIII 0.0017 0.0097 0.0103
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0008 0.0009
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0096 0.0094
Schistosoma mansoni biogenic amine (5HT) receptor 0.0017 0.0097 0.0103
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0737 0.9406 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0103
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0139 0.0139
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0153 0.0154
Brugia malayi sulfakinin receptor protein 0.0017 0.0097 0.0103
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0017 0.0097 0.0097
Echinococcus granulosus cysteine protease 0.001 0.0008 0.0009
Echinococcus granulosus expressed conserved protein 0.0089 0.1029 0.1094
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0036 0.0342 0.029
Brugia malayi G protein-coupled receptor F59B2.13 0.0017 0.0097 0.0103
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0012 0.0023 0.0014
Loa Loa (eye worm) hypothetical protein 0.002 0.0135 0.0144
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0097 0.0097
Echinococcus multilocularis lipoxygenase domain containing protein 0.0046 0.0469 0.0469
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.017 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0103
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0017 0.0097 0.0103
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.0097 0.0103
Echinococcus multilocularis sex peptide receptor 0.0017 0.0097 0.0097
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.0709 0.0754
Schistosoma mansoni hypothetical protein 0.0015 0.0071 0.0075
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0096 0.0094
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0017 0.0097 0.0103
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0049 0.0043
Mycobacterium ulcerans aminopeptidase N PepN 0.0103 0.1204 1
Plasmodium vivax amine transporter, putative 0.0012 0.0023 0.0016
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0737 0.9406 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0139 0.0139
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0135 0.0135
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0017 0.0097 0.0103
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0135 0.0135
Schistosoma mansoni hypothetical protein 0.0039 0.0382 0.0407
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0079 0.0894 0.0951
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0101
Brugia malayi hypothetical protein 0.0017 0.0097 0.0103
Brugia malayi hypothetical protein 0.0012 0.0023 0.0025
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0139 0.0148
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0103
Loa Loa (eye worm) TYRA-2 protein 0.0017 0.0097 0.0103
Loa Loa (eye worm) cysteine protease 0.002 0.0135 0.0144
Schistosoma mansoni gabp alpha 0.0079 0.0894 0.0951
Brugia malayi hypothetical protein 0.0017 0.0097 0.0103
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0.0097 0.0097
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0012 0.0023 0.0025
Echinococcus multilocularis g-protein coupled receptor 0.0017 0.0097 0.0097
Brugia malayi putative neuropeptide receptor 0.0017 0.0097 0.0103
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0103
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0103
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0017 0.0097 0.0097
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0135 0.0135
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0036 0.0342 0.0355
Echinococcus multilocularis sodium and chloride dependent glycine 0.0012 0.0023 0.0023
Giardia lamblia Sgs1 DNA helicase, putative 0.0022 0.0153 0.0015
Onchocerca volvulus 0.002 0.0135 0.0144
Schistosoma mansoni hypothetical protein 0.0017 0.0097 0.0103
Echinococcus multilocularis Niemann Pick C1 protein 0.0095 0.1103 0.1103
Echinococcus granulosus cpg binding protein 0.0029 0.0253 0.0269
Schistosoma mansoni biogenic amine (5HT) receptor 0.0155 0.1873 0.1992
Loa Loa (eye worm) fli-1 protein 0.024 0.2973 0.316
Brugia malayi AMP-binding enzyme family protein 0.0023 0.017 0.0181
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0036 0.0342 0.0355
Schistosoma mansoni DNA helicase recq1 0.0022 0.0153 0.0163
Loa Loa (eye worm) hypothetical protein 0.0015 0.0071 0.0075
Onchocerca volvulus 0.0023 0.017 0.0181
Schistosoma mansoni hypothetical protein 0.0017 0.0097 0.0103
Echinococcus granulosus aminopeptidase N 0.0267 0.3331 0.3541
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0737 0.9406 1
Schistosoma mansoni hypothetical protein 0.0039 0.0382 0.0407
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0103 0.1204 0.1273
Loa Loa (eye worm) hypothetical protein 0.0011 0.0022 0.0023
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0737 0.9406 0.9406
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0017 0.0097 0.0103
Schistosoma mansoni hypothetical protein 0.0033 0.0299 0.0318
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0017 0.0097 0.0103
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0103
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0036 0.0342 0.0355
Loa Loa (eye worm) hypothetical protein 0.0068 0.0756 0.0803
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0017
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0016 0.0008
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0097 0.0103
Schistosoma mansoni ets 0.0011 0.0022 0.0023
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0095 0.0013
Echinococcus multilocularis somatostatin receptor 0.0017 0.0097 0.0097
Leishmania major cathepsin L-like protease 0.0077 0.087 0.0855
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0036 0.0342 0.0363
Schistosoma mansoni growth hormone secretagogue receptor 0.0017 0.0097 0.0103
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0097 0.0103
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0135 0.0135
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0022 0.0153 0.0163
Schistosoma mansoni hypothetical protein 0.0015 0.0071 0.0075
Schistosoma mansoni hypothetical protein 0.0056 0.0603 0.0641
Echinococcus granulosus RUN 0.0046 0.0469 0.0499
Schistosoma mansoni cpg binding protein 0.0029 0.0253 0.0269
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0103
Schistosoma mansoni neuropeptide receptor 0.0017 0.0097 0.0103
Brugia malayi hypothetical protein 0.0017 0.0097 0.0103
Schistosoma mansoni DNA helicase recq5 0.0022 0.0153 0.0163
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0139 0.0148
Loa Loa (eye worm) hypothetical protein 0.0197 0.2421 0.2574
Schistosoma mansoni sodium/chloride dependent transporter 0.0012 0.0023 0.0025
Loa Loa (eye worm) hypothetical protein 0.0012 0.0023 0.0025
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0103
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0016 0.0006
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0737 0.9406 1
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0015 0.0071 0.0067
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0097 0.0103
Brugia malayi Cathepsin L-like precursor 0.002 0.0135 0.0144
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0139 0.0139
Onchocerca volvulus 0.0068 0.0756 0.0803
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0096 0.0096
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0135 0.0135
Echinococcus granulosus cathepsin L 0.001 0.0008 0.0009
Onchocerca volvulus 0.0017 0.0097 0.0103
Brugia malayi hypothetical protein 0.0017 0.0097 0.0103
Toxoplasma gondii hypothetical protein 0.0012 0.0023 0.0014
Echinococcus multilocularis dro:myosuppressin receptor 0.0017 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0101
Toxoplasma gondii aminopeptidase N, putative 0.0036 0.0342 0.0352
Brugia malayi AMP-binding enzyme family protein 0.0023 0.017 0.0181
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0135 0.0135
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0135 0.0135
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0097 0.0097
Schistosoma mansoni aryl hydrocarbon receptor 0.0059 0.0633 0.0673
Echinococcus granulosus g protein coupled receptor 0.0017 0.0097 0.0103
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.017 0.0675
Loa Loa (eye worm) hypothetical protein 0.0012 0.0023 0.0025
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0071 0.0075
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0096 0.0103
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0634 0.0675
Echinococcus multilocularis lamin dm0 0.0029 0.0254 0.0254
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0012 0.0023 0.0014
Brugia malayi Muscleblind-like protein 0.0144 0.1739 0.1849
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0096 0.0103
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0153 0.0154
Loa Loa (eye worm) hypothetical protein 0.0155 0.1873 0.1992
Loa Loa (eye worm) hypothetical protein 0.0067 0.0737 0.0783
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0017 0.0097 0.0103
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0008 0.0009
Brugia malayi Dopamine receptor 0.0017 0.0097 0.0103
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0017 0.0097 0.0103
Leishmania major cathepsin L-like protease 0.002 0.0135 0.0069
Loa Loa (eye worm) hypothetical protein 0.0029 0.0247 0.0263
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0077 0.0082
Brugia malayi Peptidase family M1 containing protein 0.0036 0.0342 0.0363
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0135 0.0144
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0103 0.1204 0.1273
Echinococcus granulosus neuropeptide FF receptor 2 0.0017 0.0097 0.0103
Schistosoma mansoni hypothetical protein 0.0017 0.0097 0.0103
Schistosoma mansoni lamin 0.0029 0.0254 0.027
Entamoeba histolytica recQ family helicase, putative 0.0011 0.0011 0.0002
Brugia malayi neuropeptide F receptor 0.0017 0.0097 0.0103
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0067 0.0737 0.0737
Echinococcus granulosus 7tm_1 domain containing protein 0.0017 0.0097 0.0103
Onchocerca volvulus 0.0012 0.0023 0.0025
Trypanosoma cruzi aminopeptidase, putative 0.0103 0.1204 0.1273
Brugia malayi Ets-domain containing protein 0.0011 0.0022 0.0023
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0097 0.0103
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0103
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0012 0.0023 0.0025
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0553 0.0577
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0.0097 0.0097
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0299 0.0318
Schistosoma mansoni hypothetical protein 0.0395 0.4982 0.5296
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0049 0.0043
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0057 0.0061
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0077 0.0082
Brugia malayi hypothetical protein 0.0035 0.0323 0.0343
Echinococcus granulosus intermediate filament protein 0.0029 0.0254 0.027
Loa Loa (eye worm) ets-domain-containing protein 0.0011 0.0022 0.0023
Echinococcus multilocularis serotonin transporter 0.0068 0.0756 0.0756
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0103
Echinococcus multilocularis g protein coupled receptor 0.0017 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0103
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0103 0.1204 0.128
Echinococcus multilocularis ewsr:fli fusion protein type 0.0011 0.0022 0.0022
Echinococcus multilocularis neuropeptide receptor 0.0017 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0014 0.005 0.0053
Echinococcus granulosus ETS transcription factor Elf 5 0.0011 0.0022 0.0023
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0022 0.0022
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.017 0.0675
Brugia malayi Cathepsin L-like precursor 0.002 0.0135 0.0144
Echinococcus multilocularis orexin receptor type 2 0.0017 0.0097 0.0097
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0095 0.0092
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0022 0.0022
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0254 0.027
Toxoplasma gondii cathepsin CPL 0.002 0.0135 0.0132
Entamoeba histolytica hypothetical protein 0.0035 0.0323 0.0335
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0103
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0139 0.0139
Loa Loa (eye worm) G-protein coupled receptor 0.0017 0.0097 0.0103
Echinococcus granulosus G protein coupled receptor 139 0.0017 0.0097 0.0103
Onchocerca volvulus 0.002 0.0135 0.0144
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0103
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0153 0.0152
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0496 0.0528
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0103
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0401 0.0401
Entamoeba histolytica hypothetical protein 0.0035 0.0323 0.0335
Loa Loa (eye worm) hypothetical protein 0.0014 0.0049 0.0052
Echinococcus granulosus single minded 2 0.0043 0.0436 0.0463
Brugia malayi Dopamine receptor protein 1 0.0017 0.0097 0.0103
Brugia malayi Cathepsin L-like precursor 0.0014 0.0049 0.0052
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0017 0.0097 0.0103
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0103
Onchocerca volvulus 0.0028 0.0232 0.0247
Brugia malayi Fli-1 protein 0.024 0.2973 0.316
Loa Loa (eye worm) hypothetical protein 0.0144 0.1739 0.1849
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0069 0.0769 0.0818
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0135 0.0144
Onchocerca volvulus 0.0103 0.1204 0.128
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0017 0.0097 0.0103
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0017 0.0097 0.0103
Loa Loa (eye worm) hypothetical protein 0.0231 0.2863 0.3044
Brugia malayi G-protein coupled receptor 0.0017 0.0097 0.0103
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.087 0.0916
Loa Loa (eye worm) hypothetical protein 0.0036 0.0342 0.0363
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.087 0.0916
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0012 0.0023 0.0025
Loa Loa (eye worm) solute carrier family 6 member 4 0.0068 0.0756 0.0803
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0103 0.1204 0.1214
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.017 0.0106
Brugia malayi Serotonin receptor 0.0017 0.0097 0.0103
Schistosoma mansoni hypothetical protein 0.0011 0.0022 0.0023
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.017 0.0172
Toxoplasma gondii aminopeptidase N protein 0.0036 0.0342 0.0352
Loa Loa (eye worm) hypothetical protein 0.0023 0.017 0.0181
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0015 0.0071 0.0067
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0135 0.0135
Leishmania major cathepsin L-like protease 0.002 0.0135 0.0069
Brugia malayi hypothetical protein 0.0017 0.0097 0.0103
Echinococcus granulosus bloom syndrome protein 0.0022 0.0153 0.0163
Echinococcus granulosus muscleblind protein 0.0144 0.1739 0.1849
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0323 0.0323
Echinococcus multilocularis G protein coupled receptor 139 0.0017 0.0097 0.0097
Trichomonas vaginalis guanylate cyclase, putative 0.0015 0.0071 0.0067
Echinococcus multilocularis cysteine protease 0.002 0.0135 0.0135
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0135 0.0135
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0153 0.0152
Plasmodium vivax vivapain-2 0.002 0.0135 0.0135
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0096 0.0103
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0097 0.0103
Onchocerca volvulus 0.0012 0.0023 0.0025
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0135 0.0135
Echinococcus granulosus protein C ets 2 0.0011 0.0022 0.0023
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0017 0.0097 0.0103
Echinococcus multilocularis GA binding protein alpha chain 0.0079 0.0894 0.0894
Loa Loa (eye worm) hypothetical protein 0.0015 0.0071 0.0076
Onchocerca volvulus Cathepsin L homolog 0.002 0.0135 0.0144
Schistosoma mansoni amine GPCR 0.0017 0.0097 0.0103
Echinococcus granulosus biogenic amine 5HT receptor 0.0017 0.0097 0.0103
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0769 0.6078
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0012 0.0023 0.0025
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0097 0.0103
Leishmania major cysteine peptidase A (CPA) 0.002 0.0135 0.0069
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0139 0.0148
Trichomonas vaginalis adenylate cyclase, putative 0.0015 0.0071 0.0067
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0103
Loa Loa (eye worm) hypothetical protein 0.0041 0.0401 0.0427
Brugia malayi Ets-domain containing protein 0.0079 0.0894 0.0951
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0022 0.0023
Plasmodium falciparum transporter, putative 0.0012 0.0023 0.0016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0023 0.0025
Schistosoma mansoni opsin-like receptor 0.0017 0.0097 0.0103
Brugia malayi follicle stimulating hormone receptor 0.0268 0.3339 0.355
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0097 0.0103
Brugia malayi RE15519p 0.0017 0.0097 0.0103
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.017 0.0106
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0103
Schistosoma mansoni single-minded 0.0059 0.0633 0.0673
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0017 0.0097 0.0103
Echinococcus granulosus lipoxygenase domain containing protein 0.0046 0.0469 0.0499
Brugia malayi GnHR receptor homolog 0.0017 0.0097 0.0103
Schistosoma mansoni amine GPCR 0.0017 0.0097 0.0103
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0015 0.0071 0.0067
Onchocerca volvulus 0.0046 0.0469 0.0499
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0015 0.0071 0.0067
Echinococcus multilocularis protein dispatched 1 0.0047 0.0476 0.0476
Brugia malayi Peptidase family M1 containing protein 0.0267 0.3331 0.3541
Leishmania major cathepsin L-like protease 0.002 0.0135 0.0069
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0139 0.0139
Echinococcus granulosus neuropeptide receptor A26 0.0017 0.0097 0.0103
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0017 0.0097 0.0103
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0254 0.027
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0783 0.0824
Onchocerca volvulus 0.002 0.0135 0.0144
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0139 0.0073
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0097 0.0097
Schistosoma mansoni polycystin 1-related 0.0046 0.0469 0.0499
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0401 0.0427
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0323 0.0343
Entamoeba histolytica recQ family helicase, putative 0.0022 0.0153 0.0154
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0036 0.0342 0.0342
Brugia malayi Cathepsin L-like precursor 0.002 0.0135 0.0144
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0017 0.0097 0.0103
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0153 0.0154
Schistosoma mansoni biogenic amine receptor 0.0017 0.0097 0.0103

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Small Molecule Agonists for Hypoxia Response Element Signaling Pathway. (Class of assay: confirmatory) [Related pubchem assays: 915 ] ChEMBL. No reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Small Molecule Antagonists for Hypoxia Response Element Signaling Pathway. (Class of assay: confirmatory) [Related pubchem assays: 914 ] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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