Detailed information for compound 1790026

Basic information

Technical information
  • TDR Targets ID: 1790026
  • Name: N-[4-(1,3-dioxoisoindol-2-yl)phenyl]acetamide
  • MW: 280.278 | Formula: C16H12N2O3
  • H donors: 1 H acceptors: 3 LogP: 1.63 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)Nc1ccc(cc1)N1C(=O)c2c(C1=O)cccc2
  • InChi: 1S/C16H12N2O3/c1-10(19)17-11-6-8-12(9-7-11)18-15(20)13-4-2-3-5-14(13)16(18)21/h2-9H,1H3,(H,17,19)
  • InChiKey: LOYJIHSAFJFQBK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[4-(1,3-dioxoisoindolin-2-yl)phenyl]acetamide
  • N-[4-(1,3-dioxo-2-isoindolinyl)phenyl]acetamide
  • N-[4-(1,3-diketoisoindolin-2-yl)phenyl]acetamide
  • N-[4-(1,3-dioxoisoindol-2-yl)phenyl]ethanamide
  • ZINC00397740
  • Oprea1_607822
  • Oprea1_515259

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens sodium channel, voltage-gated, type II, alpha subunit Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania donovani calcium channel protein, putative Get druggable targets OG5_126819 All targets in OG5_126819
Leishmania braziliensis calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
Echinococcus multilocularis sodium channel protein Get druggable targets OG5_126819 All targets in OG5_126819
Leishmania mexicana calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
Leishmania major calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
Leishmania infantum calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit Get druggable targets OG5_126819 All targets in OG5_126819
Echinococcus granulosus sodium channel protein Get druggable targets OG5_126819 All targets in OG5_126819
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major DNA polymerase eta, putative 0.0021 0.0036 0.0431
Mycobacterium leprae Probable lipase LipE 0.0039 0.0142 0.0247
Loa Loa (eye worm) melatonin receptor type 1A 0.006 0.027 0.062
Brugia malayi Importin beta-1 subunit 0.0031 0.0097 0.0223
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0063 0.0749
Echinococcus granulosus microtubule associated protein 2 0.0681 0.3909 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0036 0.0058
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0267 0.3195
Loa Loa (eye worm) apoptosis regulator protein 0.0088 0.0434 0.0997
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.006 0.027 0.0657
Echinococcus multilocularis neuropeptide FF receptor 2 0.006 0.027 0.0256
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0142 0.0369
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0036 0.0023
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.027 0.0256
Loa Loa (eye worm) hypothetical protein 0.0039 0.0142 0.0327
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.006 0.027 0.062
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.011 0.0252
Mycobacterium ulcerans lipase LipD 0.0039 0.0142 0.0348
Echinococcus granulosus neuropeptides capa receptor 0.006 0.027 0.0657
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0041 0.0154 0.0141
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.006 0.027 0.0256
Loa Loa (eye worm) hypothetical protein 0.018 0.0974 0.2239
Echinococcus multilocularis lamin dm0 0.0084 0.0408 0.0395
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0063 0.0749
Brugia malayi AKH receptor 0.006 0.027 0.062
Echinococcus granulosus ubiquitin specific protease 41 0.0157 0.0834 0.2107
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0057 0.0103
Echinococcus granulosus neuropeptide receptor 0.006 0.027 0.0657
Echinococcus granulosus g protein coupled receptor 0.006 0.027 0.0657
Loa Loa (eye worm) hypothetical protein 0.006 0.027 0.062
Brugia malayi ORL1-like opioid receptor 0.006 0.027 0.062
Schistosoma mansoni apoptosis regulator bax 0.0088 0.0434 0.1091
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0013 0.011
Loa Loa (eye worm) hypothetical protein 0.006 0.027 0.062
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0234 0.2808
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.027 0.0657
Loa Loa (eye worm) hypothetical protein 0.006 0.027 0.062
Leishmania major alpha glucosidase II subunit, putative 0.0039 0.0143 0.1715
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0282 0.0701
Loa Loa (eye worm) hypothetical protein 0.0021 0.0036 0.0083
Echinococcus granulosus g protein coupled receptor 0.006 0.027 0.0657
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0267 0.0663
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0178 0.2137
Brugia malayi G-protein coupled receptor 0.006 0.027 0.062
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0142 0.0369
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0036 0.0295
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0087 0.0424 0.0976
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.0741 0.0728
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0036 0.0083
Echinococcus granulosus geminin 0.0543 0.31 0.7922
Schistosoma mansoni opsin-like receptor 0.006 0.027 0.067
Brugia malayi CHE-14 protein 0.0087 0.0424 0.0976
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0015 0.0005
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.006 0.027 0.062
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0036 0.0083
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0282 0.0648
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0224 0.0603
Echinococcus multilocularis smad 0.0025 0.0064 0.005
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0036 0.0072
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.027 0.067
Loa Loa (eye worm) ICD-1 protein 0.0038 0.0136 0.0312
Brugia malayi hypothetical protein 0.0022 0.0044 0.0101
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0064 0.005
Echinococcus granulosus chromobox protein 1 0.0074 0.0352 0.0868
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0013 0.0031
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0036 0.0295
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0142 0.1164
Brugia malayi Dopamine receptor protein 1 0.006 0.027 0.062
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.006 0.027 0.0256
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.0741 0.1867
Schistosoma mansoni alpha glucosidase 0.0039 0.0143 0.0346
Echinococcus multilocularis lysosomal alpha glucosidase 0.0175 0.0942 0.093
Echinococcus granulosus 7tm_1 domain containing protein 0.006 0.027 0.0657
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.006 0.027 0.067
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0247 0.1365 0.3876
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0044 0.0078
Loa Loa (eye worm) hypothetical protein 0.0024 0.0057 0.0131
Schistosoma mansoni hypothetical protein 0.0072 0.0336 0.0839
Schistosoma mansoni hypothetical protein 0.006 0.027 0.067
Echinococcus granulosus tm gpcr rhodopsin 0.006 0.027 0.0657
Schistosoma mansoni biogenic amine (dopamine) receptor 0.006 0.027 0.067
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.027 0.067
Schistosoma mansoni neuropeptide receptor 0.006 0.027 0.067
Brugia malayi G protein-coupled receptor F59B2.13 0.006 0.027 0.062
Loa Loa (eye worm) G-protein coupled receptor 0.006 0.027 0.062
Loa Loa (eye worm) doublecortin family protein 0.0022 0.0044 0.0101
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0057 0.0125
Echinococcus multilocularis sex peptide receptor 0.006 0.027 0.0256
Echinococcus multilocularis microtubule associated protein 2 0.0681 0.3909 0.3901
Mycobacterium ulcerans hypothetical protein 0.0039 0.0142 0.0348
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0143 0.1715
Brugia malayi Serotonin receptor 0.006 0.027 0.062
Schistosoma mansoni lamin 0.0084 0.0408 0.1026
Echinococcus granulosus dro:myosuppressin receptor 0.006 0.027 0.0657
Echinococcus granulosus snurportin 1 0.0331 0.1856 0.4729
Echinococcus multilocularis g protein coupled receptor 0.006 0.027 0.0256
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.027 0.067
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0064 0.005
Loa Loa (eye worm) hypothetical protein 0.02 0.1088 0.2502
Loa Loa (eye worm) hypothetical protein 0.006 0.027 0.062
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.0424 0.5087
Brugia malayi TAR-binding protein 0.0062 0.0282 0.0648
Schistosoma mansoni lamin 0.0084 0.0408 0.1026
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.027 0.0256
Onchocerca volvulus 0.0017 0.0015 0.0177
Echinococcus multilocularis geminin 0.0543 0.31 0.309
Echinococcus granulosus Niemann Pick C1 protein 0.0289 0.1611 0.4101
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.006 0.027 0.0256
Schistosoma mansoni opsin-like receptor 0.006 0.027 0.067
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0057 0.0682
Schistosoma mansoni hypothetical protein 0.0017 0.0015 0.0018
Brugia malayi Dopamine receptor protein 2 0.006 0.027 0.062
Onchocerca volvulus Huntingtin homolog 0.0131 0.0683 0.7977
Onchocerca volvulus 0.006 0.027 0.3151
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0015 0.0005
Loa Loa (eye worm) hypothetical protein 0.0033 0.0107 0.0246
Loa Loa (eye worm) hypothetical protein 0.006 0.027 0.062
Loa Loa (eye worm) hypothetical protein 0.02 0.1088 0.2502
Leishmania major hypothetical protein, conserved 0.0039 0.0142 0.1703
Echinococcus multilocularis neuropeptide Y receptor 0.006 0.027 0.0256
Schistosoma mansoni DNA polymerase eta 0.0021 0.0036 0.0072
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0054 0.0234 0.2808
Schistosoma mansoni biogenic amine (dopamine) receptor 0.006 0.027 0.067
Entamoeba histolytica hypothetical protein 0.0072 0.0338 0.3072
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.0035
Onchocerca volvulus 0.0039 0.0142 0.1661
Echinococcus granulosus caspase 2 0.0066 0.03 0.0735
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0282 0.0648
Echinococcus multilocularis mitogen activated protein kinase 3 0.0054 0.0234 0.0221
Echinococcus multilocularis ubiquitin specific protease 41 0.0157 0.0834 0.0822
Echinococcus multilocularis G protein coupled receptor 139 0.006 0.027 0.0256
Schistosoma mansoni smad1 5 8 and 0.0025 0.0064 0.0143
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.006 0.027 0.0256
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.016 0.1915
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0057 0.0131
Onchocerca volvulus Huntingtin homolog 0.0131 0.0683 0.7977
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0338 0.0834
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.027 0.0256
Brugia malayi Intermediate filament tail domain containing protein 0.0084 0.0408 0.0939
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0013 0.011
Brugia malayi hypothetical protein 0.006 0.027 0.062
Plasmodium vivax multidomain scavenger receptor, putative 0.0022 0.0044 0.0087
Onchocerca volvulus 0.0022 0.0044 0.0513
Schistosoma mansoni hypothetical protein 0.0222 0.122 0.3107
Schistosoma mansoni hypothetical protein 0.0084 0.0406 0.102
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0054 0.0234 0.192
Echinococcus granulosus hypothetical protein 0.006 0.027 0.0657
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.006 0.027 0.0657
Onchocerca volvulus 0.006 0.027 0.3151
Echinococcus multilocularis Smad4 0.0025 0.0064 0.005
Brugia malayi Niemann-Pick C1 protein precursor 0.0202 0.1102 0.2533
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.006 0.027 0.067
Mycobacterium ulcerans hypothetical protein 0.0024 0.0057 0.0103
Echinococcus granulosus Niemann Pick C1 protein 0.0202 0.1102 0.2794
Echinococcus multilocularis MAM 0.0017 0.0015 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0157 0.0834 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0036 0.0431
Loa Loa (eye worm) hypothetical protein 0.0131 0.0683 0.1569
Schistosoma mansoni biogenic amine (5HT) receptor 0.006 0.027 0.067
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0054 0.0234 0.0539
Echinococcus granulosus sex peptide receptor 0.006 0.027 0.0657
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0097 0.0794
Loa Loa (eye worm) hypothetical protein 0.006 0.027 0.062
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0013 0.0014
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0157 0.0834 0.2107
Echinococcus multilocularis G-protein coupled receptor, putative 0.006 0.027 0.0256
Echinococcus granulosus Protein patched homolog 1 0.0087 0.0424 0.1055
Echinococcus granulosus importin subunit beta 1 0.0031 0.0097 0.0214
Echinococcus multilocularis orexin receptor type 2 0.006 0.027 0.0256
Echinococcus granulosus lysosomal alpha glucosidase 0.0175 0.0942 0.2384
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0057 0.0682
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.011 0.0247
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0036 0.0072
Brugia malayi hypothetical protein 0.006 0.027 0.062
Echinococcus multilocularis GPCR, family 2 0.0033 0.011 0.0096
Brugia malayi hypothetical protein 0.0053 0.0224 0.0514
Echinococcus granulosus mitogen activated protein kinase 3 0.0054 0.0234 0.0567
Echinococcus granulosus neuropeptide Y receptor 0.006 0.027 0.0657
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.027 0.0256
Brugia malayi hypothetical protein 0.006 0.027 0.062
Loa Loa (eye worm) hypothetical protein 0.0041 0.0153 0.0352
Loa Loa (eye worm) hypothetical protein 0.006 0.027 0.062
Echinococcus multilocularis neuropeptides capa receptor 0.006 0.027 0.0256
Schistosoma mansoni hypothetical protein 0.0084 0.0406 0.102
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0088 0.0434 0.1079
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0142 0.0348
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0611 0.3502 1
Brugia malayi chromobox protein homolog 3 0.0042 0.016 0.0367
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0142 0.0327
Brugia malayi gonadotropin-releasing hormone receptor 2 0.006 0.027 0.062
Onchocerca volvulus 0.006 0.027 0.3151
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0142 0.1703
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0157 0.0834 0.6836
Echinococcus multilocularis neuropeptide receptor 0.006 0.027 0.0256
Brugia malayi hypothetical protein 0.0034 0.0114 0.0263
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0041 0.0154 0.1262
Echinococcus multilocularis snurportin 1 0.0331 0.1856 0.1845
Onchocerca volvulus 0.006 0.027 0.3151
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0036 0.0295
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0041 0.0154 0.1847
Plasmodium falciparum importin beta, putative 0.0031 0.0097 0.0239
Echinococcus multilocularis apoptotic protease activating factor 1 0.0066 0.03 0.0287
Entamoeba histolytica transcription factor BTF3, putative 0.0038 0.0136 0.123
Loa Loa (eye worm) hypothetical protein 0.0039 0.0144 0.0331
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0036 0.0295
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0157 0.0834 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0048
Brugia malayi Heterochromatin protein 1 0.0074 0.0352 0.0808
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0143 0.1715
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0039 0.0143 0.0329
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.027 0.0657
Onchocerca volvulus 0.0101 0.0509 0.5952
Loa Loa (eye worm) hypothetical protein 0.006 0.027 0.062
Schistosoma mansoni smad 0.0025 0.0064 0.0143
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0234 0.2808
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0088 0.0434 0.1079
Schistosoma mansoni neuropeptide F-like receptor 0.006 0.027 0.067
Schistosoma mansoni histamine h1 receptor 0.006 0.027 0.067
Loa Loa (eye worm) hypothetical protein 0.0039 0.0142 0.0327
Echinococcus multilocularis biogenic amine (5HT) receptor 0.006 0.027 0.0256
Loa Loa (eye worm) hypothetical protein 0.016 0.0856 0.1967
Loa Loa (eye worm) MH2 domain-containing protein 0.0372 0.2097 0.4821
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0267 0.065
Echinococcus granulosus tm gpcr rhodopsin 0.006 0.027 0.0657
Loa Loa (eye worm) RNA binding protein 0.0062 0.0282 0.0648
Brugia malayi putative neuropeptide receptor NPR1 0.006 0.027 0.062
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0048
Echinococcus multilocularis chromobox protein 1 0.0074 0.0352 0.0339
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0036 0.0295
Loa Loa (eye worm) hypothetical protein 0.006 0.027 0.062
Echinococcus granulosus smad 0.0025 0.0064 0.0129
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0036 0.0295
Loa Loa (eye worm) hypothetical protein 0.0066 0.03 0.0689
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0143 0.1715
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0142 0.0129
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0064 0.0143
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0141 0.0741 0.1703
Brugia malayi hypothetical protein 0.0017 0.0015 0.0035
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0157 0.0834 1
Loa Loa (eye worm) G-protein coupled receptor 0.006 0.027 0.062
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0048
Onchocerca volvulus 0.006 0.027 0.3151
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0057 0.0103
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0157 0.0834 1
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.027 0.0657
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0097 0.0084
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.027 0.0256
Loa Loa (eye worm) hypothetical protein 0.0033 0.011 0.0252
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0036 0.0431
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0157 0.0834 0.0822
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0234 0.2808
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0044 0.0078
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0057 0.0103
Brugia malayi Serotonin/octopamine receptor family protein 7 0.006 0.027 0.062
Loa Loa (eye worm) hypothetical protein 0.0084 0.0408 0.0939
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0041 0.0153 0.014
Schistosoma mansoni lipoxygenase 0.0022 0.0044 0.0092
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0013 0.0031
Mycobacterium tuberculosis Conserved protein 0.0039 0.0142 0.0369
Brugia malayi Glycosyl hydrolases family 31 protein 0.0175 0.0942 0.2167
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0036 0.0431
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.006 0.027 0.0256
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.0741 0.0728
Brugia malayi hypothetical protein 0.0131 0.0683 0.1569
Schistosoma mansoni hypothetical protein 0.0543 0.31 0.7925
Brugia malayi Smad1 0.0025 0.0064 0.0147
Brugia malayi hypothetical protein 0.006 0.027 0.062
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0611 0.3502 1
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0041 0.0154 0.0361
Echinococcus granulosus neuropeptides capa receptor 0.006 0.027 0.0657
Schistosoma mansoni biogenic amine (5HT) receptor 0.02 0.1088 0.2769
Loa Loa (eye worm) neuropeptide F receptor 0.006 0.027 0.062
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.016 0.1867
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.027 0.0657
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0088 0.0434 0.0997
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.0741 0.1867
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0157 0.0834 0.7571
Echinococcus multilocularis caspase 2 0.0066 0.03 0.0287
Brugia malayi Calcitonin receptor-like protein seb-1 0.0105 0.053 0.1219
Echinococcus granulosus biogenic amine 5HT receptor 0.006 0.027 0.0657
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0175 0.0942 0.2167
Schistosoma mansoni amine GPCR 0.006 0.027 0.067
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.0035
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0041 0.0154 0.1398
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0338 0.0847
Echinococcus granulosus G protein coupled receptor 139 0.006 0.027 0.0657
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0041 0.0154 0.1847
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0036 0.0431
Brugia malayi MH2 domain containing protein 0.0372 0.2097 0.4821
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.006 0.027 0.062
Echinococcus granulosus intermediate filament protein 0.0084 0.0408 0.1013
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0157 0.0834 1
Schistosoma mansoni opsin-like receptor 0.006 0.027 0.067
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0041 0.0154 0.0354
Onchocerca volvulus 0.0016 0.0008 0.0095
Loa Loa (eye worm) neuropeptide F receptor 0.006 0.027 0.062
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.0035
Schistosoma mansoni biogenic amine receptor 0.006 0.027 0.067
Loa Loa (eye worm) hypothetical protein 0.0053 0.0224 0.0514
Brugia malayi hypothetical protein 0.0066 0.03 0.0689
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0036 0.0043
Echinococcus multilocularis musashi 0.0084 0.0408 0.0395
Echinococcus multilocularis chromobox protein 1 0.0074 0.0352 0.0339
Loa Loa (eye worm) hypothetical protein 0.006 0.027 0.062
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0142 0.0369
Brugia malayi Melatonin receptor type 1A 0.006 0.027 0.062
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0054 0.0234 0.2808
Brugia malayi SEA domain containing protein 0.0016 0.0008 0.0019
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0064 0.0147
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0282 0.0701
Plasmodium vivax importin-beta 2, putative 0.0031 0.0097 0.0239
Brugia malayi sulfakinin receptor protein 0.006 0.027 0.062
Schistosoma mansoni hypothetical protein 0.0033 0.011 0.0261
Onchocerca volvulus 0.0016 0.0008 0.0095
Echinococcus multilocularis transcription factor btf3 0.0038 0.0136 0.0122
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.0741 0.1878
Schistosoma mansoni alpha-glucosidase 0.0151 0.0799 0.2028
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0142 0.1703
Brugia malayi neuropeptide F receptor 0.006 0.027 0.062
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0141 0.0741 0.1703
Brugia malayi larval opioid receptor 0.006 0.027 0.062
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0157 0.0834 0.1918
Mycobacterium ulcerans beta-lactamase 0.0039 0.0142 0.0348
Brugia malayi beta-lactamase family protein 0.0039 0.0142 0.0327
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.027 0.0256
Echinococcus multilocularis somatostatin receptor 0.006 0.027 0.0256
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0267 1
Echinococcus granulosus mitogen activated protein kinase 0.0054 0.0234 0.0567
Leishmania major basic transcription factor 3a, putative 0.0038 0.0136 0.1625
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0352 0.4214
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.006 0.027 0.0256
Echinococcus multilocularis RUN 0.0022 0.0044 0.0031
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0036 0.0295
Echinococcus multilocularis g protein coupled receptor 0.006 0.027 0.0256
Loa Loa (eye worm) hypothetical protein 0.006 0.027 0.062
Schistosoma mansoni alpha-glucosidase 0.0151 0.0799 0.2028
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0057 0.0103
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.006 0.027 0.0657
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0036 0.0023
Loa Loa (eye worm) hypothetical protein 0.0106 0.0539 0.1239
Echinococcus granulosus expressed conserved protein 0.019 0.103 0.2609
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0142 0.1703
Toxoplasma gondii NAC domain-containing protein 0.0038 0.0136 0.4824
Brugia malayi hypothetical protein 0.016 0.0856 0.1967
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0142 0.0247
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0064 0.0129
Echinococcus multilocularis neuropeptide receptor A26 0.006 0.027 0.0256
Trypanosoma brucei protein kinase, putative 0.0054 0.0234 0.192
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0282 0.0648
Loa Loa (eye worm) hypothetical protein 0.0202 0.1102 0.2533
Loa Loa (eye worm) hypothetical protein 0.006 0.027 0.062
Echinococcus granulosus neuropeptide s receptor 0.006 0.027 0.0657
Loa Loa (eye worm) hypothetical protein 0.006 0.027 0.062
Trichomonas vaginalis sucrase-isomaltase, putative 0.0039 0.0143 0.1715
Echinococcus multilocularis lamin 0.0084 0.0408 0.0395
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.027 0.067
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.006 0.027 0.0256
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0036 0.0327
Brugia malayi RNA, U transporter 1 0.0088 0.0432 0.0993
Schistosoma mansoni neuropeptide receptor 0.006 0.027 0.067
Echinococcus granulosus g protein coupled receptor 0.006 0.027 0.0657
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.0741 0.1878
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.006 0.027 0.3151
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0157 0.0834 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0054 0.0234 0.2808
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0041 0.0154 0.0403
Onchocerca volvulus 0.0024 0.0057 0.0665
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0143 0.1715
Onchocerca volvulus 0.016 0.0856 1
Brugia malayi Muscle positioning protein 4 0.0016 0.0008 0.0019
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0282 0.0269
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0041 0.0154 0.0354
Onchocerca volvulus 0.0039 0.0142 0.1661
Loa Loa (eye worm) hypothetical protein 0.006 0.027 0.062
Echinococcus multilocularis tachykinin peptides receptor 99D 0.006 0.027 0.0256
Schistosoma mansoni neuropeptide F-like receptor 0.006 0.027 0.067
Echinococcus multilocularis expressed conserved protein 0.019 0.103 0.1018
Echinococcus granulosus sterol regulatory element binding protein 0.0087 0.0424 0.1055
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0036 0.0295
Giardia lamblia Kinase, CMGC MAPK 0.0054 0.0234 0.2484
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0136 0.1625
Loa Loa (eye worm) hypothetical protein 0.006 0.027 0.062
Echinococcus multilocularis sodium channel protein 0.0045 0.0181 0.0168
Schistosoma mansoni caspase-7 (C14 family) 0.0066 0.03 0.0748
Brugia malayi Doublecortin family protein 0.0022 0.0044 0.0101
Schistosoma mansoni alpha-1 adrenergic receptor 0.006 0.027 0.067
Loa Loa (eye worm) hypothetical protein 0.0016 0.0008 0.0019
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0136 0.1625
Echinococcus granulosus 7TM GPCR rhodopsin 0.006 0.027 0.0657
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0267 0.0705
Loa Loa (eye worm) hypothetical protein 0.0039 0.0142 0.0327
Loa Loa (eye worm) hypothetical protein 0.006 0.027 0.062
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0142 0.1703
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.027 0.067
Loa Loa (eye worm) hypothetical protein 0.0016 0.0008 0.0019
Entamoeba histolytica hypothetical protein 0.0072 0.0338 0.3072
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0097 0.0794
Loa Loa (eye worm) hypothetical protein 0.006 0.027 0.062
Echinococcus granulosus GPCR family 2 0.0033 0.011 0.0247
Echinococcus granulosus biogenic amine 5HT receptor 0.02 0.1088 0.2759
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.006 0.027 0.067
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0013 0.0161
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0041 0.0154 0.1847
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0041 0.0154 0.5556
Schistosoma mansoni transcription factor btf3 0.0038 0.0136 0.0327
Schistosoma mansoni loxhd1 0.0022 0.0044 0.0092
Echinococcus granulosus dna polymerase kappa 0.0021 0.0036 0.0058
Loa Loa (eye worm) hypothetical protein 0.006 0.027 0.062
Echinococcus multilocularis neuropeptide receptor 0.006 0.027 0.0256
Loa Loa (eye worm) hypothetical protein 0.0024 0.0057 0.0131
Onchocerca volvulus 0.006 0.027 0.3151
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0036 0.0431
Schistosoma mansoni neuropeptide receptor 0.006 0.027 0.067
Echinococcus granulosus orexin receptor type 2 0.006 0.027 0.0657
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0234 0.2808
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.027 0.067
Echinococcus granulosus tm gpcr rhodopsin 0.006 0.027 0.0657
Echinococcus granulosus MAM 0.0017 0.0015 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0036 0.0295
Brugia malayi MH1 domain containing protein 0.0025 0.0064 0.0147
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0013 0.0161
Echinococcus multilocularis neutral alpha glucosidase AB 0.0039 0.0143 0.013
Plasmodium falciparum LCCL domain-containing protein 0.0022 0.0044 0.0087
Schistosoma mansoni hypothetical protein 0.0017 0.0015 0.0018
Echinococcus multilocularis protein patched 0.0087 0.0424 0.0412
Brugia malayi MH1 domain containing protein 0.0025 0.0064 0.0147
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0044 0.0031
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0224 0.0603
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.027 0.0256
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0063 0.0749
Echinococcus multilocularis muscleblind protein 0.018 0.0974 0.0962
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0267 0.0705
Onchocerca volvulus 0.0017 0.0015 0.0177
Loa Loa (eye worm) hypothetical protein 0.006 0.027 0.062
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0267 0.0726
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.006 0.027 0.0256
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0234 0.2808
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.0044 0.0078
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0234 0.2808
Echinococcus granulosus lamin dm0 0.0084 0.0408 0.1013
Onchocerca volvulus 0.006 0.027 0.3151
Echinococcus multilocularis mitogen activated protein kinase 0.0054 0.0234 0.0221
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0036 0.0295
Schistosoma mansoni hypothetical protein 0.0022 0.0044 0.0092
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0084 0.0408 0.0939
Brugia malayi hypothetical protein 0.0072 0.0338 0.0778
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0142 0.0348
Brugia malayi Cell death protein 3 precursor 0.0066 0.03 0.0689
Entamoeba histolytica hypothetical protein 0.0072 0.0338 0.3072
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0267 0.0253
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.027 0.067
Echinococcus granulosus somatostatin receptor 0.006 0.027 0.0657
Loa Loa (eye worm) hypothetical protein 0.006 0.027 0.062
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0036 0.0431
Echinococcus granulosus sodium channel protein 0.0045 0.0181 0.043
Brugia malayi G protein-coupled receptor 0.006 0.027 0.062
Brugia malayi hypothetical protein 0.006 0.027 0.062
Brugia malayi beta-lactamase 0.0039 0.0142 0.0327
Brugia malayi RNA binding protein 0.0062 0.0282 0.0648
Loa Loa (eye worm) hypothetical protein 0.0082 0.0399 0.0918
Schistosoma mansoni myosin xvIII 0.006 0.027 0.067
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0142 0.0369
Brugia malayi hypothetical protein 0.006 0.027 0.062
Schistosoma mansoni rab6-interacting 0.0022 0.0044 0.0092
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0057 0.0516
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0143 0.1715
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0157 0.0834 0.2118
Brugia malayi hypothetical protein 0.006 0.027 0.062
Mycobacterium tuberculosis Conserved protein 0.0039 0.0142 0.0369
Schistosoma mansoni amine GPCR 0.006 0.027 0.067
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0142 0.0344
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0267 0.0663
Loa Loa (eye worm) hypothetical protein 0.006 0.027 0.062
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0036 0.0295
Brugia malayi Latrophilin receptor protein 2 0.0033 0.011 0.0252
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0143 0.1715
Echinococcus granulosus muscleblind protein 0.018 0.0974 0.2465
Loa Loa (eye worm) hypothetical protein 0.0087 0.0424 0.0976
Brugia malayi Tachykinin-like peptides receptor 99D 0.006 0.027 0.062
Loa Loa (eye worm) hypothetical protein 0.0131 0.0683 0.1569
Treponema pallidum hypothetical protein 0.0611 0.3502 0.5
Onchocerca volvulus 0.006 0.027 0.3151
Onchocerca volvulus 0.0084 0.0408 0.4771
Loa Loa (eye worm) hypothetical protein 0.006 0.027 0.062
Echinococcus multilocularis neuropeptides capa receptor 0.006 0.027 0.0256
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0015 0.0005
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.006 0.027 0.0256
Echinococcus multilocularis g protein coupled receptor 0.006 0.027 0.0256
Echinococcus multilocularis Niemann Pick C1 protein 0.0289 0.1611 0.16
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0036 0.0295
Brugia malayi Serotonin receptor 0.006 0.027 0.062
Loa Loa (eye worm) DOMON domain-containing protein 0.0016 0.0008 0.0019
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0021 0.0022
Brugia malayi neuropeptide F receptor 0.006 0.027 0.062
Schistosoma mansoni microtubule-associated protein tau 0.0681 0.3909 1
Schistosoma mansoni neuropeptide f receptor 76f 0.006 0.027 0.067
Schistosoma mansoni hypothetical protein 0.0088 0.0434 0.1091
Brugia malayi MH2 domain containing protein 0.0025 0.0064 0.0147
Loa Loa (eye worm) hypothetical protein 0.0105 0.053 0.1219
Trypanosoma brucei RNA helicase, putative 0.0222 0.122 1
Brugia malayi Muscleblind-like protein 0.018 0.0974 0.2239
Loa Loa (eye worm) hypothetical protein 0.0039 0.0142 0.0327
Loa Loa (eye worm) hypothetical protein 0.006 0.027 0.062
Schistosoma mansoni biogenic amine receptor 0.006 0.027 0.067
Brugia malayi Dopamine receptor 0.006 0.027 0.062
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0097 0.3298
Brugia malayi isocitrate dehydrogenase 0.0017 0.0013 0.0031
Leishmania major importin beta-1 subunit, putative 0.0025 0.0063 0.0749
Brugia malayi beta-lactamase family protein 0.0039 0.0142 0.0327
Schistosoma mansoni hypothetical protein 0.0033 0.011 0.0261
Onchocerca volvulus 0.0033 0.0107 0.1249
Onchocerca volvulus 0.006 0.027 0.3151
Loa Loa (eye worm) hypothetical protein 0.006 0.027 0.062
Echinococcus granulosus neuropeptide FF receptor 2 0.006 0.027 0.0657
Echinococcus granulosus chromobox protein 1 0.0074 0.0352 0.0868
Loa Loa (eye worm) hypothetical protein 0.006 0.027 0.062
Schistosoma mansoni amine GPCR 0.006 0.027 0.067
Loa Loa (eye worm) hypothetical protein 0.0042 0.016 0.0367
Loa Loa (eye worm) hypothetical protein 0.0022 0.0044 0.0101
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0045 0.0181 0.2169
Schistosoma mansoni hypothetical protein 0.0088 0.0434 0.1091
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0057 0.0103
Schistosoma mansoni amine GPCR 0.006 0.027 0.067
Echinococcus multilocularis dna polymerase eta 0.0021 0.0036 0.0023
Schistosoma mansoni hypothetical protein 0.0066 0.03 0.0748
Brugia malayi beta-NAC-like protein 0.0038 0.0136 0.0312
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0036 0.0295
Loa Loa (eye worm) beta-lactamase 0.0039 0.0142 0.0327
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0282 0.0701
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0021 0.0022
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0224 0.1833
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0048
Loa Loa (eye worm) hypothetical protein 0.006 0.027 0.062
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0105 0.053 0.1219
Loa Loa (eye worm) hypothetical protein 0.006 0.027 0.062
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0142 0.0369
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0178 0.2084
Loa Loa (eye worm) hypothetical protein 0.018 0.0974 0.2239
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0041 0.0154 0.0354
Onchocerca volvulus 0.0084 0.0408 0.4771
Schistosoma mansoni Smad4 0.0025 0.0064 0.0143
Entamoeba histolytica hypothetical protein 0.0072 0.0338 0.3072
Loa Loa (eye worm) hypothetical protein 0.0039 0.0142 0.0327
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.006 0.027 0.067
Echinococcus multilocularis protein dispatched 1 0.0099 0.0496 0.0484
Schistosoma mansoni importin beta-1 0.0031 0.0097 0.0228
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0036 0.0431
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0234 0.058
Loa Loa (eye worm) hypothetical protein 0.006 0.027 0.062
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.016 0.1915
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0224 0.2682
Schistosoma mansoni hypothetical protein 0.006 0.027 0.067
Brugia malayi GnHR receptor homolog 0.006 0.027 0.062
Schistosoma mansoni amine GPCR 0.006 0.027 0.067
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0178 0.2137
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0224 0.2682
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0057 0.0103
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.006 0.027 0.067
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0039 0.0143 0.512
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0136 0.1625
Echinococcus multilocularis dro:myosuppressin receptor 0.006 0.027 0.0256
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.006 0.027 0.067
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0143 0.1715
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.006 0.027 0.062
Brugia malayi hypothetical protein 0.006 0.027 0.062
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0142 0.033
Loa Loa (eye worm) hypothetical protein 0.006 0.027 0.062
Loa Loa (eye worm) TK/ALK protein kinase 0.0017 0.0015 0.0035
Trichomonas vaginalis esterase, putative 0.0039 0.0142 0.1703
Echinococcus granulosus fmrfamide receptor 0.006 0.027 0.0657
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0142 0.0369
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0224 0.8308
Echinococcus multilocularis fmrfamide receptor 0.006 0.027 0.0256
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0021 0.5
Echinococcus granulosus neutral alpha glucosidase AB 0.0039 0.0143 0.0333
Onchocerca volvulus 0.006 0.027 0.3151
Onchocerca volvulus 0.0039 0.0142 0.1661
Schistosoma mansoni hypothetical protein 0.0024 0.0054 0.0116
Schistosoma mansoni peptide (allatostatin)-like receptor 0.006 0.027 0.067
Brugia malayi hypothetical protein 0.0022 0.0044 0.0101
Loa Loa (eye worm) hypothetical protein 0.0024 0.0057 0.0131
Onchocerca volvulus 0.0066 0.03 0.3503
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.027 0.0657
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0036 0.0043
Schistosoma mansoni polycystin 1-related 0.0022 0.0044 0.0092
Echinococcus multilocularis alpha 1A adrenergic receptor 0.006 0.027 0.0256
Loa Loa (eye worm) transcription factor SMAD2 0.0372 0.2097 0.4821
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0142 0.1703
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0064 0.0129
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0136 0.1625
Schistosoma mansoni lipoxygenase 0.0061 0.0276 0.0686
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0013 0.0161
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0143 0.1298
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0088 0.1059
Echinococcus granulosus neuropeptide receptor 0.006 0.027 0.0657
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0142 0.0369
Plasmodium falciparum basic transcription factor 3b, putative 0.0038 0.0136 0.035
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0338 0.0325
Entamoeba histolytica hypothetical protein 0.0038 0.0136 0.123
Loa Loa (eye worm) hypothetical protein 0.0072 0.0336 0.0772
Loa Loa (eye worm) hypothetical protein 0.006 0.027 0.062
Loa Loa (eye worm) hypothetical protein 0.006 0.027 0.062
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0036 0.0065
Echinococcus granulosus Smad4 0.0025 0.0064 0.0129
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0142 0.0344
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0611 0.3502 1
Echinococcus granulosus g-protein coupled receptor 0.006 0.027 0.0657
Loa Loa (eye worm) hypothetical protein 0.0039 0.0144 0.0331
Leishmania major DNA polymerase kappa, putative 0.0021 0.0036 0.0431
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0282 0.0701
Echinococcus granulosus tachykinin peptides receptor 99D 0.006 0.027 0.0657
Onchocerca volvulus 0.0022 0.0044 0.0513
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0061 0.0276 0.0673
Echinococcus multilocularis fmrfamide receptor 0.006 0.027 0.0256
Loa Loa (eye worm) hypothetical protein 0.0066 0.03 0.0689
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.006 0.027 0.0256
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.011 0.0247
Onchocerca volvulus 0.006 0.027 0.3151
Schistosoma mansoni chromobox protein 0.0074 0.0352 0.088
Brugia malayi G-protein coupled receptor 0.006 0.027 0.062
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0157 0.0834 0.2118
Entamoeba histolytica hypothetical protein 0.0025 0.0063 0.0567
Schistosoma mansoni hypothetical protein 0.0033 0.011 0.0261
Loa Loa (eye worm) hypothetical protein 0.006 0.027 0.062
Echinococcus multilocularis sterol regulatory element binding protein 0.0087 0.0424 0.0412
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0267 0.0705
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0088 0.1059
Echinococcus granulosus serotonin receptor 0.006 0.027 0.0657
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0611 0.3502 1
Echinococcus granulosus lamin 0.0084 0.0408 0.1013
Brugia malayi Protein kinase domain containing protein 0.0017 0.0015 0.0035
Schistosoma mansoni hypothetical protein 0.0033 0.011 0.0261
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.006 0.027 0.062
Trichomonas vaginalis maltase-glucoamylase, putative 0.0039 0.0143 0.1715
Schistosoma mansoni adenoreceptor 0.006 0.027 0.067
Loa Loa (eye worm) heterochromatin protein 1 0.0074 0.0352 0.0808
Loa Loa (eye worm) hypothetical protein 0.0031 0.0097 0.0223
Echinococcus multilocularis Niemann Pick C1 protein 0.0202 0.1102 0.109
Trypanosoma brucei unspecified product 0.0021 0.0036 0.0295
Mycobacterium tuberculosis Conserved protein 0.0039 0.0142 0.0369
Schistosoma mansoni biogenic amine (dopamine) receptor 0.006 0.027 0.067
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.006 0.027 0.067
Loa Loa (eye worm) hypothetical protein 0.006 0.027 0.062
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0611 0.3502 1
Schistosoma mansoni hypothetical protein 0.006 0.027 0.067
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.0741 0.1878
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.011 0.0096
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0064 0.0147
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.027 0.0256
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0136 0.1625
Onchocerca volvulus 0.0016 0.0008 0.0095
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.011 0.0096
Onchocerca volvulus Neuropeptide F receptor homolog 0.006 0.027 0.3151
Onchocerca volvulus 0.006 0.027 0.3151
Schistosoma mansoni hypothetical protein 0.006 0.027 0.067
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0041 0.0154 0.0374
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0157 0.0834 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0057 0.0682
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0054 0.0234 0.8726
Echinococcus granulosus RUN 0.0022 0.0044 0.0078
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.006 0.027 0.062
Echinococcus multilocularis lysosomal alpha glucosidase 0.0175 0.0942 0.093
Brugia malayi RE15519p 0.006 0.027 0.062
Schistosoma mansoni rab6-interacting 0.0022 0.0044 0.0092
Onchocerca volvulus 0.006 0.027 0.3151
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.006 0.027 0.0657
Echinococcus granulosus tar DNA binding protein 0.0062 0.0282 0.0689
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.006 0.027 0.067
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0088 0.0434 0.0421
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.027 0.067
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.006 0.027 0.067
Echinococcus granulosus alpha 1A adrenergic receptor 0.006 0.027 0.0657
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0041 0.0153 0.0358
Loa Loa (eye worm) hypothetical protein 0.006 0.027 0.062
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0088 0.0434 0.1091
Loa Loa (eye worm) hypothetical protein 0.006 0.027 0.062
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0036 0.0295
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0282 0.0701
Echinococcus granulosus peptide allatostatin:somatostatin 0.006 0.027 0.0657
Brugia malayi Glycosyl hydrolases family 31 protein 0.0039 0.0143 0.0329
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0331 0.1856 0.4267
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0054 0.0234 0.2808
Loa Loa (eye worm) hypothetical protein 0.006 0.027 0.062
Echinococcus granulosus apoptotic protease activating factor 1 0.0066 0.03 0.0735
Loa Loa (eye worm) hypothetical protein 0.0039 0.0142 0.0327
Loa Loa (eye worm) hypothetical protein 0.006 0.027 0.062
Echinococcus multilocularis serotonin receptor 0.02 0.1088 0.1076
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0036 0.0431
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0021 0.0022
Leishmania major hypothetical protein, conserved 0.0053 0.0224 0.2682
Onchocerca volvulus 0.006 0.027 0.3151
Echinococcus multilocularis allatostatin A receptor 0.006 0.027 0.0256
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0143 0.1298
Loa Loa (eye worm) hypothetical protein 0.006 0.027 0.062
Echinococcus granulosus allatostatin A receptor 0.006 0.027 0.0657
Schistosoma mansoni hypothetical protein 0.0052 0.0219 0.0541
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.0044 0.0031
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0057 0.0125
Schistosoma mansoni patched 1 0.0087 0.0424 0.1067
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0045 0.0179 0.0412
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0142 0.0327
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.0336 0.0772
Echinococcus granulosus dna polymerase eta 0.0021 0.0036 0.0058
Brugia malayi intermediate filament protein 0.0084 0.0408 0.0939
Onchocerca volvulus 0.006 0.027 0.3151
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.006 0.027 0.062
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.006 0.027 0.0657
Schistosoma mansoni chromobox protein 0.0074 0.0352 0.088
Brugia malayi MH2 domain containing protein 0.0025 0.0064 0.0147
Brugia malayi putative neuropeptide receptor 0.006 0.027 0.062
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0045 0.0181 0.043
Onchocerca volvulus Cell death protein 3 homolog 0.0066 0.03 0.3503
Brugia malayi hypothetical protein 0.006 0.027 0.062
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0057 0.0131
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0054 0.0103
Onchocerca volvulus 0.006 0.027 0.3151
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0063 0.0749
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0142 0.0369
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0041 0.0154 0.1847
Loa Loa (eye worm) hypothetical protein 0.006 0.027 0.062
Brugia malayi follicle stimulating hormone receptor 0.0756 0.4349 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0143 0.1715
Loa Loa (eye worm) TYRA-2 protein 0.006 0.027 0.062
Echinococcus granulosus thyrotropin releasing hormone receptor 0.006 0.027 0.0657
Plasmodium vivax basic transcription factor 3b, putative 0.0038 0.0136 0.035
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0756 0.4349 1
Echinococcus multilocularis neuropeptide s receptor 0.006 0.027 0.0256
Onchocerca volvulus 0.0016 0.0008 0.0095
Brugia malayi cytoplasmic intermediate filament protein 0.0045 0.0179 0.0412
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.006 0.027 0.0256
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0205 0.112 0.2851
Schistosoma mansoni smad1 5 8 and 0.0025 0.0064 0.0143
Schistosoma mansoni hypothetical protein 0.0084 0.0406 0.102
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0041 0.0154 0.1847
Trypanosoma brucei transcription factor BTF3, putative 0.0038 0.0136 0.1111
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0054 0.004
Schistosoma mansoni hypothetical protein 0.0331 0.1856 0.4737
Schistosoma mansoni smad1 5 8 and 0.0025 0.0064 0.0143
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0057 0.0131
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0352 0.4214
Toxoplasma gondii ABC1 family protein 0.0039 0.0142 0.5083
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0036 0.0065
Loa Loa (eye worm) hypothetical protein 0.0157 0.0834 0.1918
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.011 0.0252
Echinococcus multilocularis muscleblind protein 1 0.018 0.0974 0.0962
Loa Loa (eye worm) hypothetical protein 0.0088 0.0434 0.0997
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0057 0.0103
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0157 0.0834 0.0822
Schistosoma mansoni hypothetical protein 0.0088 0.0434 0.1091
Onchocerca volvulus 0.0016 0.0008 0.0095
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0044 0.0031
Onchocerca volvulus 0.006 0.027 0.3151
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0061 0.0276 0.0263
Echinococcus multilocularis serotonin receptor 0.02 0.1088 0.1076
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.027 0.067
Loa Loa (eye worm) hypothetical protein 0.006 0.027 0.062
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0041 0.0154 0.0354
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0157 0.0834 0.2107
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0036 0.0083
Trypanosoma brucei glucosidase, putative 0.0039 0.0143 0.1172
Echinococcus granulosus neuropeptide Y receptor 0.006 0.027 0.0657
Loa Loa (eye worm) hypothetical protein 0.006 0.027 0.062
Schistosoma mansoni neuropeptide receptor 0.006 0.027 0.067
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0143 0.1715
Loa Loa (eye worm) hypothetical protein 0.006 0.027 0.062
Schistosoma mansoni biogenic amine receptor 0.006 0.027 0.067
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0015 0.0005
Schistosoma mansoni intermediate filament proteins 0.0084 0.0408 0.1026
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0142 0.1703
Brugia malayi MAP kinase sur-1 0.0054 0.0234 0.0539
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0088 0.0434 0.0421
Schistosoma mansoni growth hormone secretagogue receptor 0.006 0.027 0.067
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0041 0.0154 0.0403
Echinococcus granulosus transcription factor btf3 0.0038 0.0136 0.0313
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0224 0.0603
Schistosoma mansoni hypothetical protein 0.0543 0.31 0.7925
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0202 0.1102 1
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.027 0.0657
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0057 0.0516
Echinococcus granulosus neuropeptide receptor A26 0.006 0.027 0.0657
Schistosoma mansoni hypothetical protein 0.0084 0.0406 0.102
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0057 0.0516
Loa Loa (eye worm) intermediate filament protein 0.0084 0.0408 0.0939
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.027 0.0657
Brugia malayi hypothetical protein 0.006 0.027 0.062
Loa Loa (eye worm) hypothetical protein 0.0022 0.0044 0.0101
Loa Loa (eye worm) hypothetical protein 0.006 0.027 0.062
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0142 0.1703
Loa Loa (eye worm) Smad1 0.0025 0.0064 0.0147
Echinococcus multilocularis g-protein coupled receptor 0.006 0.027 0.0256
Echinococcus multilocularis neuropeptide Y receptor 0.006 0.027 0.0256
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0105 0.053 0.1219
Schistosoma mansoni hypothetical protein 0.0072 0.0338 0.0847

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 40.37 mg kg-1 Anticonvulsant activity in pentylenetetrazole-induced seizure Swiss Mus musculus (mouse) model assessed as increase in clonic seizure threshold at 40 mg/kg, ip measured after 30 min (Rvb = 38.9 +/-1.01 mg/kg) ChEMBL. No reference
Activity (functional) = 86.37 mg kg-1 Anticonvulsant activity in pentylenetetrazole-induced seizure Swiss Mus musculus (mouse) model assessed as increase in tonic seizure threshold at 40 mg/kg, ip measured after 30 min (Rvb = 59.58 +/-1.01 mg/kg) ChEMBL. No reference
Ki (binding) = 18.27 uM Binding affinity to Nav 1.2 (unknown origin) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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