Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | cytochrome P450 125A7 Cyp125A7 | 0.0033 | 0.2605 | 0.5 |
Echinococcus multilocularis | 0.0033 | 0.2605 | 0.4761 | |
Trypanosoma brucei | Lanosterol 14-alpha demethylase | 0.0033 | 0.2605 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.5122 | 0.5122 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.5122 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 1 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0033 | 0.2605 | 0.2605 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0033 | 0.2605 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 105Q4 Cyp105Q4 | 0.0033 | 0.2605 | 0.5 |
Mycobacterium ulcerans | cytochrome p450 150 cyp150 | 0.0033 | 0.2605 | 0.5 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0033 | 0.2605 | 0.4761 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0008 | 0.0316 | 0.0316 |
Brugia malayi | cytochrome P450 | 0.0033 | 0.2605 | 0.2605 |
Brugia malayi | Cytochrome P450 family protein | 0.0033 | 0.2605 | 0.2605 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0008 | 0.0316 | 0.0316 |
Mycobacterium ulcerans | cytochrome P450 191A3 Cyp191A3 | 0.0033 | 0.2605 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 124A1, Cyp124A1 | 0.0033 | 0.2605 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 123A3 Cyp123A3 | 0.0033 | 0.2605 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.3579 | 0.3579 |
Mycobacterium ulcerans | cytochrome P450 143A4 Cyp143A4 | 0.0033 | 0.2605 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.5122 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0033 | 0.2605 | 0.2605 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0033 | 0.2605 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 | 0.0033 | 0.2605 | 0.2605 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0033 | 0.2605 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.5122 | 0.5122 |
Mycobacterium ulcerans | cytochrome P450 187A5 Cyp187A5 | 0.0033 | 0.2605 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0033 | 0.2605 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0033 | 0.2605 | 0.2605 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.3579 | 0.3579 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.2605 | 0.4761 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.5122 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0033 | 0.2605 | 0.2605 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0033 | 0.2605 | 0.2605 |
Trypanosoma brucei | cytochrome P450, putative | 0.0033 | 0.2605 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0033 | 0.2605 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0033 | 0.2605 | 0.5 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0033 | 0.2605 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.0316 | 0.0316 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0033 | 0.2605 | 0.5 |
Leishmania major | lanosterol 14-alpha-demethylase, putative | 0.0033 | 0.2605 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 108B4 Cyp108B4 | 0.0033 | 0.2605 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.3579 | 0.6789 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.5122 | 0.5122 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0033 | 0.2605 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.5122 | 0.5122 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.3579 | 0.6789 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0033 | 0.2605 | 0.5 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.0316 | 0.0316 |
Mycobacterium ulcerans | cytochrome P450 187A4 Cyp187A4 | 0.0033 | 0.2605 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0033 | 0.2605 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0033 | 0.2605 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.5122 | 1 |
Mycobacterium ulcerans | cytochrome P450 189A7 Cyp189A7 | 0.0033 | 0.2605 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.3579 | 0.6789 |
Mycobacterium ulcerans | cytochrome P450 51B1 Cyp51B1 | 0.0033 | 0.2605 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 136A2 Cyp136A2 | 0.0033 | 0.2605 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0033 | 0.2605 | 0.2605 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.3579 | 0.6789 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0033 | 0.2605 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.3579 | 0.6789 |
Schistosoma mansoni | cytochrome P450 | 0.0033 | 0.2605 | 0.4761 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0033 | 0.2605 | 0.5 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0033 | 0.2605 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.3579 | 0.6789 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0033 | 0.2605 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.5122 | 1 |
Loa Loa (eye worm) | Smad1 | 0.0008 | 0.0316 | 0.0316 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0033 | 0.2605 | 0.5 |
Trypanosoma cruzi | cytochrome p450-like protein, putative | 0.0033 | 0.2605 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0033 | 0.2605 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0033 | 0.2605 | 0.5 |
Brugia malayi | RNA binding protein | 0.0062 | 0.5122 | 0.5122 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.3579 | 0.6789 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0033 | 0.2605 | 0.5 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.0316 | 0.0316 |
Mycobacterium ulcerans | cytochrome P450 188A3 Cyp188A3 | 0.0033 | 0.2605 | 0.5 |
Mycobacterium leprae | putative cytochrome p450 | 0.0033 | 0.2605 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 142A3 Cyp142A3 | 0.0033 | 0.2605 | 0.5 |
Brugia malayi | Smad1 | 0.0008 | 0.0316 | 0.0316 |
Mycobacterium ulcerans | cytochrome P450 126A3 Cyp126A3 | 0.0033 | 0.2605 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.5122 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0033 | 0.2605 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0033 | 0.2605 | 0.5 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0033 | 0.2605 | 0.5 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0033 | 0.2605 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0033 | 0.2605 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.5122 | 0.5122 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0033 | 0.2605 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 144A4 Cyp144A4 | 0.0033 | 0.2605 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0033 | 0.2605 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0033 | 0.2605 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0033 | 0.2605 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.5122 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0033 | 0.2605 | 0.2605 |
Mycobacterium ulcerans | cytochrome P450 143A3 Cyp143A3 | 0.0033 | 0.2605 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 150A6 Cyp150A6 | 0.0033 | 0.2605 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 140A5 Cyp140A5 | 0.0033 | 0.2605 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0033 | 0.2605 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.0316 | 0.0316 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.