Detailed information for compound 1804113

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 287.423 | Formula: C16H21N3S
  • H donors: 1 H acceptors: 0 LogP: 3.41 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: S=C(N1CCC(=N1)c1ccccc1)NC1CCCCC1
  • InChi: 1S/C16H21N3S/c20-16(17-14-9-5-2-6-10-14)19-12-11-15(18-19)13-7-3-1-4-8-13/h1,3-4,7-8,14H,2,5-6,9-12H2,(H,17,20)
  • InChiKey: XNVRFZBXWRHFKU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0239 0.021
Echinococcus granulosus jumonji domain containing protein 0.0121 0.1545 0.1526
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.021 0.2923 0.8273
Plasmodium vivax JmjC domain containing protein 0.0028 0.0111 0.0282
Schistosoma mansoni jumonji domain containing protein 0.0226 0.3169 1
Onchocerca volvulus 0.0033 0.0192 0.0507
Schistosoma mansoni hypothetical protein 0.0036 0.0239 0.0755
Echinococcus multilocularis survival motor neuron protein 1 0.0239 0.3365 0.3345
Echinococcus granulosus cathepsin L cysteine proteinase 0.0033 0.0192 0.017
Schistosoma mansoni protein phosphatase 2C 0.0028 0.0111 0.0351
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0609 0.0588
Toxoplasma gondii ABC1 family protein 0.0035 0.0222 0.1464
Leishmania major hypothetical protein, conserved 0.0035 0.0222 0.0725
Leishmania major cathepsin L-like protease 0.0033 0.0192 0.053
Brugia malayi jmjC domain containing protein 0.0107 0.1332 0.3234
Schistosoma mansoni hypothetical protein 0.0176 0.2402 0.7579
Brugia malayi Cathepsin L-like precursor 0.0033 0.0192 0.0419
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0033 0.0192 0.0544
Leishmania major cathepsin L-like protease 0.0033 0.0192 0.053
Onchocerca volvulus Cathepsin L homolog 0.0033 0.0192 0.0507
Loa Loa (eye worm) hypothetical protein 0.0047 0.041 0.1159
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0222 0.0596
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0222 0.02
Brugia malayi Kinesin motor domain containing protein 0.0026 0.0085 0.0155
Brugia malayi Cathepsin L-like precursor 0.0033 0.0192 0.0419
Echinococcus granulosus JmjC domain containing protein 4 0.0028 0.0111 0.0089
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0028 0.0117 0.0036
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0192 0.783
Schistosoma mansoni hypothetical protein 0.0028 0.0117 0.0369
Echinococcus granulosus lysine specific demethylase 6a 0.0028 0.0111 0.0089
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.041 0.0381
Loa Loa (eye worm) hypothetical protein 0.0033 0.0192 0.0544
Echinococcus granulosus peregrin 0.0089 0.1057 0.1037
Echinococcus granulosus lamin 0.0054 0.0505 0.0483
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0079 0.0898 0.0871
Brugia malayi Pre-SET motif family protein 0.003 0.0144 0.03
Schistosoma mansoni cellular tumor antigen P53 0.0098 0.1189 0.3752
Echinococcus granulosus GPCR family 2 0.0079 0.0898 0.0878
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0222 0.07
Schistosoma mansoni survival motor neuron protein 0.0049 0.043 0.1358
Schistosoma mansoni hypothetical protein 0.0079 0.0898 0.2834
Schistosoma mansoni hypothetical protein 0.0049 0.043 0.1358
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0192 0.0507
Onchocerca volvulus 0.0033 0.0192 0.0507
Echinococcus granulosus jumonji domain containing 1A 0.0028 0.0111 0.0089
Echinococcus multilocularis PHD finger protein rhinoceros 0.0087 0.102 0.0993
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.1636 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0111 0.0315
Entamoeba histolytica hypothetical protein 0.0036 0.0239 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0033 0.0192 0.0507
Onchocerca volvulus Cathepsin L homolog 0.0033 0.0192 0.0507
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0192 0.0507
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0079 0.0898 0.0878
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0033 0.0192 0.0507
Toxoplasma gondii PHD-finger domain-containing protein 0.0087 0.102 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0222 0.0596
Loa Loa (eye worm) hypothetical protein 0.0043 0.0343 0.0971
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0028 0.0111 0.0282
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.041 0.0388
Loa Loa (eye worm) hypothetical protein 0.0035 0.0222 0.0628
Brugia malayi AF-10 protein 0.0028 0.0117 0.0233
Brugia malayi Papain family cysteine protease containing protein 0.0033 0.0192 0.0419
Echinococcus multilocularis JmjC domain containing protein 4 0.0028 0.0111 0.0082
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0239 0.0209
Entamoeba histolytica hypothetical protein 0.0036 0.0239 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0033 0.0192 0.0163
Onchocerca volvulus Alhambra homolog 0.0087 0.102 0.2979
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.003 0.0094
Giardia lamblia PHD finger protein 15 0.0087 0.102 1
Echinococcus granulosus kinesin family 1 0.0203 0.2808 0.2792
Leishmania major cathepsin L-like protease 0.0127 0.1636 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0192 0.0507
Brugia malayi jmjC domain containing protein 0.0028 0.0111 0.022
Echinococcus multilocularis jumonji domain containing 1A 0.0028 0.0111 0.0082
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0192 0.0507
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.003 0.0008
Echinococcus multilocularis kinesin family 1 0.0203 0.2808 0.2787
Brugia malayi PHD-finger family protein 0.003 0.0147 0.0307
Echinococcus multilocularis tumor protein p63 0.0669 1 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0222 0.0193
Mycobacterium ulcerans lipase LipD 0.0035 0.0222 0.5
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0033 0.0192 0.0163
Plasmodium vivax hypothetical protein, conserved 0.0087 0.102 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0222 0.0725
Mycobacterium ulcerans hypothetical protein 0.0035 0.0222 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0192 0.0507
Schistosoma mansoni lamin 0.0054 0.0505 0.1592
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.0111 0.0315
Onchocerca volvulus 0.0054 0.0505 0.144
Echinococcus multilocularis jumonji domain containing protein 0.0121 0.1545 0.152
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0033 0.0192 0.1146
Leishmania major cathepsin L-like protease 0.0033 0.0192 0.053
Schistosoma mansoni cathepsin F (C01 family) 0.0033 0.0192 0.0606
Loa Loa (eye worm) latrophilin receptor protein 2 0.0079 0.0898 0.2542
Onchocerca volvulus Cathepsin F homolog 0.0033 0.0192 0.0507
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0222 0.0596
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0222 0.5
Onchocerca volvulus 0.003 0.0144 0.0363
Loa Loa (eye worm) PHD-finger family protein 0.0087 0.102 0.2887
Schistosoma mansoni jumonji/arid domain-containing protein 0.0107 0.1332 0.4203
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0505 0.1428
Brugia malayi beta-lactamase family protein 0.0035 0.0222 0.0493
Leishmania major cathepsin L-like protease 0.0033 0.0192 0.053
Loa Loa (eye worm) hypothetical protein 0.0149 0.1978 0.56
Loa Loa (eye worm) hypothetical protein 0.0025 0.0062 0.0175
Onchocerca volvulus 0.0049 0.043 0.1218
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0116 0.1466 0.8886
Brugia malayi beta-lactamase 0.0035 0.0222 0.0493
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0222 0.0493
Echinococcus multilocularis lysine specific demethylase 6a 0.0028 0.0111 0.0082
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0192 0.0507
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0505 0.1428
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0087 0.102 0.3218
Brugia malayi F/Y-rich N-terminus family protein 0.0031 0.0164 0.0349
Loa Loa (eye worm) hypothetical protein 0.0035 0.0222 0.0628
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0028 0.0111 0.0282
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0505 0.1191
Toxoplasma gondii cathepsin CPL 0.0033 0.0192 0.1146
Leishmania major cysteine peptidase A (CPA) 0.0033 0.0192 0.053
Plasmodium vivax vivapain-2 0.0033 0.0192 0.1146
Loa Loa (eye worm) ctsf protein 0.0033 0.0192 0.0544
Schistosoma mansoni phd/f-box containing protein 0.0028 0.0111 0.0351
Echinococcus multilocularis lysine specific demethylase 5A 0.0105 0.1302 0.1276
Brugia malayi jmjC domain containing protein 0.0028 0.0111 0.022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0192 0.0507
Loa Loa (eye worm) hypothetical protein 0.0171 0.2313 0.6548
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0028 0.0117 0.0036
Echinococcus granulosus intermediate filament protein 0.0054 0.0505 0.0483
Echinococcus granulosus survival motor neuron protein 1 0.0239 0.3365 0.335
Loa Loa (eye worm) hypothetical protein 0.0025 0.0062 0.0175
Echinococcus multilocularis lamin dm0 0.0054 0.0505 0.0476
Trypanosoma cruzi cysteine peptidase, putative 0.0127 0.1636 1
Schistosoma mansoni intermediate filament proteins 0.0054 0.0505 0.1592
Onchocerca volvulus 0.0098 0.1189 0.3484
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.003 0.0141 0.0119
Leishmania major cathepsin L-like protease 0.0033 0.0192 0.053
Echinococcus multilocularis cathepsin L cysteine protease 0.0033 0.0192 0.0163
Loa Loa (eye worm) MH2 domain-containing protein 0.0239 0.337 0.9538
Loa Loa (eye worm) hypothetical protein 0.0053 0.0489 0.1385
Schistosoma mansoni phosphatidylserine receptor 0.0028 0.0111 0.0351
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0222 0.0725
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.1636 1
Onchocerca volvulus 0.0033 0.0192 0.0507
Schistosoma mansoni kinesin eg-5 0.0026 0.0085 0.0268
Onchocerca volvulus 0.0033 0.0192 0.0507
Trichomonas vaginalis set domain proteins, putative 0.0239 0.3371 1
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0239 0.0755
Plasmodium vivax SET domain protein, putative 0.003 0.0144 0.0628
Brugia malayi hypothetical protein 0.0036 0.0239 0.0536
Brugia malayi MH2 domain containing protein 0.0239 0.337 0.8265
Loa Loa (eye worm) hypothetical protein 0.0035 0.0222 0.0628
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0192 0.783
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.043 0.1007
Loa Loa (eye worm) cysteine protease 0.0033 0.0192 0.0544
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0222 0.0596
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0117 0.0341
Mycobacterium leprae Probable lipase LipE 0.0035 0.0222 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.1636 1
Brugia malayi intermediate filament protein 0.0054 0.0505 0.1191
Brugia malayi Bromodomain containing protein 0.0039 0.0275 0.0625
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0144 0.0628
Echinococcus multilocularis GPCR, family 2 0.0079 0.0898 0.0871
Onchocerca volvulus 0.0035 0.0222 0.0596
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0079 0.0898 0.2162
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0192 0.0507
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0222 0.0725
Schistosoma mansoni mixed-lineage leukemia protein mll 0.003 0.0134 0.0423
Schistosoma mansoni hypothetical protein 0.0171 0.2313 0.73
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0192 0.0507
Schistosoma mansoni cathepsin F (C01 family) 0.0033 0.0192 0.0606
Onchocerca volvulus 0.0033 0.0192 0.0507
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0144 0.0453
Onchocerca volvulus 0.0033 0.0192 0.0507
Loa Loa (eye worm) hypothetical protein 0.0039 0.0277 0.0783
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.041 0.1292
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0222 0.07
Schistosoma mansoni cathepsin F (C01 family) 0.0022 0.0022 0.007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0192 0.0507
Schistosoma mansoni jumonji domain containing protein 0.0028 0.0111 0.0351
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0028 0.0117 0.0341
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0121 0.0244
Brugia malayi jmjC domain containing protein 0.0028 0.0111 0.022
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0028 0.0111 0.0351
Brugia malayi Cathepsin L-like precursor 0.0033 0.0192 0.0419
Echinococcus multilocularis phd:f box containing protein 0.0028 0.0111 0.0082
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0285 0.4072 0.4059
Loa Loa (eye worm) hypothetical protein 0.025 0.3533 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0144 0.0114
Loa Loa (eye worm) hypothetical protein 0.0028 0.0111 0.0315
Echinococcus multilocularis peregrin 0.0089 0.1057 0.103
Brugia malayi jmjC domain containing protein 0.0285 0.4072 1
Brugia malayi hypothetical protein 0.0239 0.3365 0.8253
Brugia malayi beta-lactamase family protein 0.0035 0.0222 0.0493
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0239 0.0217
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.0111 0.0315
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0077 0.0047
Echinococcus granulosus cathepsin l1 0.0033 0.0192 0.017
Echinococcus multilocularis lamin 0.0054 0.0505 0.0476
Loa Loa (eye worm) hypothetical protein 0.0239 0.3365 0.9524
Echinococcus granulosus cathepsin l cysteine peptidase 0.0033 0.0192 0.017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0192 0.0507
Trypanosoma cruzi cysteine peptidase, putative 0.0127 0.1636 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.025 0.3533 0.8669
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.1636 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0898 0.2542
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.1636 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0179 0.2448 0.693
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0285 0.4072 0.4055
Leishmania major cathepsin L-like protease 0.0127 0.1636 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0222 0.0596
Trypanosoma cruzi cruzipain precursor, putative 0.0127 0.1636 1
Brugia malayi Cathepsin L-like precursor 0.0033 0.0192 0.0419
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.1636 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0022 0.0063
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0192 0.0507
Echinococcus granulosus lamin dm0 0.0054 0.0505 0.0483
Plasmodium vivax vivapain-2 0.0033 0.0192 0.1146
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0192 0.0507
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0192 0.0507
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.1636 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0144 0.0453
Onchocerca volvulus 0.0054 0.0505 0.144
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0028 0.0117 0.0341
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0192 0.0507
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0222 0.5
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.0111 0.0315
Loa Loa (eye worm) pigment dispersing factor receptor c 0.025 0.3533 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0192 0.0507
Brugia malayi Bromodomain containing protein 0.0089 0.1057 0.2554
Brugia malayi PHD-finger family protein 0.0087 0.102 0.2463
Trypanosoma cruzi major cysteine proteinase, putative 0.01 0.1217 0.7252
Loa Loa (eye worm) hypothetical protein 0.0041 0.0313 0.0887
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.3151 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0192 0.0507
Loa Loa (eye worm) beta-lactamase 0.0035 0.0222 0.0628
Brugia malayi jmjC domain containing protein 0.0028 0.0111 0.022
Leishmania major cathepsin L-like protease 0.0127 0.1636 1
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0222 0.1464
Echinococcus granulosus PHD finger protein rhinoceros 0.0087 0.102 0.1
Toxoplasma gondii PHD-finger domain-containing protein 0.0087 0.102 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0077 0.0218
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.1636 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0222 0.5
Echinococcus multilocularis cathepsin L cysteine protease 0.0033 0.0192 0.0163
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.1636 1
Brugia malayi Pre-SET motif family protein 0.021 0.2923 0.7162
Loa Loa (eye worm) hypothetical protein 0.0098 0.1189 0.3366
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0117 0.0341
Plasmodium falciparum JmjC domain-containing protein, putative 0.0028 0.0111 0.0282
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0127 0.0105
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.1636 1
Schistosoma mansoni hypothetical protein 0.0079 0.0898 0.2834
Entamoeba histolytica kinesin, putative 0.0026 0.0085 0.289
Echinococcus multilocularis musashi 0.0054 0.0505 0.0476
Trichomonas vaginalis esterase, putative 0.0035 0.0222 0.0596
Loa Loa (eye worm) hypothetical protein 0.0071 0.0781 0.221
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0192 0.0507
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0192 0.0507
Brugia malayi Cathepsin L-like precursor 0.0033 0.0192 0.0419
Schistosoma mansoni jumonji/arid domain-containing protein 0.0107 0.1332 0.4203
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0033 0.0192 0.1146
Loa Loa (eye worm) transcription factor SMAD2 0.0239 0.337 0.9538
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.025 0.3533 0.8669
Echinococcus multilocularis cysteine protease 0.0033 0.0192 0.0163
Echinococcus granulosus lysine specific demethylase 5A 0.0107 0.1332 0.1313
Plasmodium falciparum phd finger protein, putative 0.0087 0.102 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0192 0.0507
Loa Loa (eye worm) hypothetical protein 0.0022 0.0022 0.0063
Trypanosoma cruzi cysteine peptidase, putative 0.0127 0.1636 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0192 0.0507
Loa Loa (eye worm) hypothetical protein 0.0054 0.0505 0.1428
Loa Loa (eye worm) hypothetical protein 0.0035 0.0222 0.0628
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0121 0.0342
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0222 0.0628
Echinococcus multilocularis cysteine protease 0.0033 0.0192 0.0163
Echinococcus granulosus phd:f box containing protein 0.0028 0.0111 0.0089
Onchocerca volvulus 0.0239 0.3371 1
Entamoeba histolytica hypothetical protein 0.0036 0.0239 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.1636 1
Brugia malayi Bromodomain containing protein 0.0076 0.0848 0.2038
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.003 0.0141 0.0112
Onchocerca volvulus 0.0035 0.0222 0.0596
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0033 0.0192 0.0544
Schistosoma mansoni hypothetical protein 0.0087 0.102 0.3218
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0239 0.0217
Loa Loa (eye worm) fibroinase 0.0033 0.0192 0.0544
Loa Loa (eye worm) hypothetical protein 0.003 0.0147 0.0415
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0192 0.0507
Loa Loa (eye worm) hypothetical protein 0.0022 0.0022 0.0063
Mycobacterium ulcerans beta-lactamase 0.0035 0.0222 0.5
Brugia malayi Cathepsin L-like precursor 0.0033 0.0192 0.0419
Loa Loa (eye worm) hypothetical protein 0.0035 0.0222 0.0628
Loa Loa (eye worm) hypothetical protein 0.0087 0.102 0.2887
Loa Loa (eye worm) kinesin-like protein KLP2 0.0026 0.0085 0.0241
Entamoeba histolytica hypothetical protein 0.0036 0.0239 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0033 0.0192 0.1146
Brugia malayi PHD-finger family protein 0.0025 0.0067 0.011
Schistosoma mansoni hypothetical protein 0.0079 0.0898 0.2834
Schistosoma mansoni bromodomain containing protein 0.0064 0.0665 0.2098
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0079 0.0898 0.0878
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0192 0.0507
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0079 0.0898 0.0871
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0609 0.0581
Entamoeba histolytica cysteine protease, putative 0.0033 0.0192 0.783
Schistosoma mansoni lamin 0.0054 0.0505 0.1592
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0077 0.0055
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.041 0.1292
Onchocerca volvulus 0.0033 0.0192 0.0507
Trypanosoma cruzi cysteine peptidase, putative 0.0033 0.0192 0.053
Loa Loa (eye worm) jmjC domain-containing protein 0.0107 0.1332 0.377
Brugia malayi Latrophilin receptor protein 2 0.0079 0.0898 0.2162
Brugia malayi latrophilin 2 splice variant baaae 0.0171 0.2313 0.5657
Schistosoma mansoni hypothetical protein 0.0079 0.0898 0.2834
Loa Loa (eye worm) hypothetical protein 0.0035 0.0222 0.0628
Onchocerca volvulus 0.0035 0.0222 0.0596

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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