Detailed information for compound 1804327

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 418.495 | Formula: C22H26N8O
  • H donors: 3 H acceptors: 6 LogP: 3.66 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(C(Nc1nc(Nc2cccc(c2)c2cncnc2)c2c(n1)n(cn2)C(C)C)O)C
  • InChi: 1S/C22H26N8O/c1-13(2)21(31)29-22-27-19(18-20(28-22)30(12-25-18)14(3)4)26-17-7-5-6-15(8-17)16-9-23-11-24-10-16/h5-14,21,31H,1-4H3,(H2,26,27,28,29)
  • InChiKey: ZSSHCAVAAPDLII-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A Starlite/ChEMBL No references
Homo sapiens cyclin A2 No references
Homo sapiens cyclin-dependent kinase 5, regulatory subunit 1 (p35) No references
Homo sapiens cyclin A1 Starlite/ChEMBL No references
Homo sapiens cyclin-dependent kinase 5 Starlite/ChEMBL No references
Sus scrofa Casein kinase 1, delta tv1 Starlite/ChEMBL No references
Sus scrofa Glycogen synthase kinase-3 Starlite/ChEMBL No references
Homo sapiens cyclin-dependent kinase 3 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Plasmodium berghei casein kinase 1, putative Get druggable targets OG5_126780 All targets in OG5_126780
Giardia lamblia Kinase, CK1 Casein kinase Get druggable targets OG5_126780 All targets in OG5_126780
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Giardia lamblia G2/mitotic-specific cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus casein kinase i Get druggable targets OG5_126780 All targets in OG5_126780
Leishmania mexicana serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania donovani CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma cruzi CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei casein kinase I, isoform 2 Get druggable targets OG5_126780 All targets in OG5_126780
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Casein kinase I: DNA repair, meiosis Get druggable targets OG5_126780 All targets in OG5_126780
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania mexicana casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis casein kinase I alpha Get druggable targets OG5_126780 All targets in OG5_126780
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase Get druggable targets OG5_126780 All targets in OG5_126780
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Onchocerca volvulus Get druggable targets OG5_126780 All targets in OG5_126780
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis casein kinase I delta Get druggable targets OG5_126780 All targets in OG5_126780
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum Cyclin-dependent kinase 5 activator 2 precursor, putative Get druggable targets OG5_133447 All targets in OG5_133447
Echinococcus granulosus dual specificity Get druggable targets OG5_127901 All targets in OG5_127901
Brugia malayi hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Leishmania infantum serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase Get druggable targets OG5_126780 All targets in OG5_126780
Leishmania braziliensis CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis casein kinase I alpha Get druggable targets OG5_126780 All targets in OG5_126780
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi casein kinase 1, delta Get druggable targets OG5_126780 All targets in OG5_126780
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum expressed protein Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma japonicum Serine/threonine-protein kinase minibrain, putative Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis cyclin A, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi casein kinase I Get druggable targets OG5_126780 All targets in OG5_126780
Schistosoma japonicum Casein kinase I isoform delta, putative Get druggable targets OG5_126780 All targets in OG5_126780
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi casein kinase, delta isoform, putative Get druggable targets OG5_126780 All targets in OG5_126780
Leishmania infantum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Theileria parva casein kinase I, putative Get druggable targets OG5_126780 All targets in OG5_126780
Echinococcus multilocularis casein kinase I alpha Get druggable targets OG5_126780 All targets in OG5_126780
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Toxoplasma gondii casein kinase I Get druggable targets OG5_126780 All targets in OG5_126780
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus granulosus cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica casein kinase 1, putative Get druggable targets OG5_126780 All targets in OG5_126780
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium falciparum casein kinase 1 Get druggable targets OG5_126780 All targets in OG5_126780
Trypanosoma congolense serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase Get druggable targets OG5_126780 All targets in OG5_126780
Trypanosoma congolense Cyclin, N-terminal domain/Cyclin, C-terminal domain containing protein, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CK1 family protein kinase Get druggable targets OG5_126780 All targets in OG5_126780
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium yoelii casein kinase i Get druggable targets OG5_126780 All targets in OG5_126780
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans Casein kinase I: DNA repair, meiosis Get druggable targets OG5_126780 All targets in OG5_126780
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum casein kinase I Get druggable targets OG5_126780 All targets in OG5_126780
Leishmania donovani serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Leishmania infantum casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis casein kinase i Get druggable targets OG5_126780 All targets in OG5_126780
Trypanosoma brucei CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus casein kinase I alpha Get druggable targets OG5_126780 All targets in OG5_126780
Entamoeba histolytica cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense casein kinase I, isoform 2 Get druggable targets OG5_126780 All targets in OG5_126780
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis dual specificity Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus granulosus cyclin dependent kinase 5 activator 1 Get druggable targets OG5_133447 All targets in OG5_133447
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans likely B-type cyclin similar to S. cerevisiae CLB4 (YLR210W) and CLB3 (YDL155W) involved in G1/S transition Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K02218 casein kinase 1, putative Get druggable targets OG5_126780 All targets in OG5_126780
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Trypanosoma cruzi casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni protein kinase Get druggable targets OG5_126780 All targets in OG5_126780
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126780 All targets in OG5_126780
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma japonicum ko:K08959 casein kinase 1, delta, putative Get druggable targets OG5_126780 All targets in OG5_126780
Echinococcus granulosus casein kinase I alpha Get druggable targets OG5_126780 All targets in OG5_126780
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Neospora caninum AFL091Wp, related Get druggable targets OG5_126780 All targets in OG5_126780
Schistosoma mansoni cyclin-dependent kinase 5 activator Get druggable targets OG5_133447 All targets in OG5_133447
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi casein kinase, delta isoform, putative Get druggable targets OG5_126780 All targets in OG5_126780
Echinococcus granulosus casein kinase I delta Get druggable targets OG5_126780 All targets in OG5_126780
Leishmania major cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Babesia bovis casein kinase I, putative Get druggable targets OG5_126780 All targets in OG5_126780
Schistosoma mansoni cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis casein kinase I delta Get druggable targets OG5_126780 All targets in OG5_126780
Plasmodium knowlesi casein kinase 1, putative Get druggable targets OG5_126780 All targets in OG5_126780
Trypanosoma brucei gambiense serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma cruzi CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cyclin 6,mitotic cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis mitotic cyclin-CYC2 Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CK1 family protein kinase Get druggable targets OG5_126780 All targets in OG5_126780
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 Get druggable targets OG5_133447 All targets in OG5_133447
Leishmania braziliensis serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CK1 family protein kinase Get druggable targets OG5_126780 All targets in OG5_126780
Leishmania braziliensis casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium vivax casein kinase 1, putative Get druggable targets OG5_126780 All targets in OG5_126780
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus casein kinase I delta Get druggable targets OG5_126780 All targets in OG5_126780
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Onchocerca volvulus Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium hominis casein kinase i Get druggable targets OG5_126780 All targets in OG5_126780
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Onchocerca volvulus Get druggable targets OG5_126780 All targets in OG5_126780
Leishmania braziliensis cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus casein kinase I alpha Get druggable targets OG5_126780 All targets in OG5_126780
Trypanosoma cruzi cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni serine/threonine protein kinase Glycogen synthase kinase-3   483 aa 397 aa 22.4 %
Leishmania mexicana casein kinase I, putative Casein kinase 1, delta tv1   415 aa 339 aa 45.4 %
Babesia bovis mitogen-activated protein kinase, putative Glycogen synthase kinase-3   483 aa 408 aa 28.9 %
Trypanosoma brucei gambiense glycogen synthase kinase-3 alpha, putative Glycogen synthase kinase-3   483 aa 456 aa 34.0 %
Echinococcus granulosus glycogen synthase kinase 3 Glycogen synthase kinase-3   483 aa 396 aa 41.4 %
Neospora caninum CAM kinase, putative Glycogen synthase kinase-3   483 aa 395 aa 26.6 %
Leishmania braziliensis casein kinase I, putative Casein kinase 1, delta tv1   415 aa 334 aa 44.6 %
Echinococcus multilocularis tyrosine protein kinase Fps85D Casein kinase 1, delta tv1   415 aa 403 aa 22.6 %
Trypanosoma cruzi glycogen synthase kinase-3 alpha, putative Glycogen synthase kinase-3   483 aa 419 aa 38.2 %
Schistosoma japonicum Casein kinase I isoform alpha, putative Casein kinase 1, delta tv1   415 aa 357 aa 55.7 %
Giardia lamblia Kinase, NEK Casein kinase 1, delta tv1   415 aa 393 aa 21.9 %
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative Glycogen synthase kinase-3   483 aa 401 aa 30.2 %
Trichomonas vaginalis CK1 family protein kinase Casein kinase 1, delta tv1   415 aa 416 aa 44.7 %
Leishmania donovani casein kinase I, putative Casein kinase 1, delta tv1   415 aa 336 aa 44.6 %
Schistosoma japonicum Serine/threonine-protein kinase Chk1, putative Glycogen synthase kinase-3   483 aa 388 aa 23.5 %
Trypanosoma brucei glycogen synthase kinase-3 alpha, putative Glycogen synthase kinase-3   483 aa 456 aa 35.1 %
Leishmania infantum casein kinase I, putative Casein kinase 1, delta tv1   415 aa 336 aa 44.3 %
Toxoplasma gondii CAM Kinase family, incomplete catalytic triad Casein kinase 1, delta tv1   415 aa 435 aa 23.0 %
Leishmania braziliensis protein kinase, putative Casein kinase 1, delta tv1   415 aa 341 aa 20.8 %
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Onchocerca volvulus Casein kinase 1, delta tv1   415 aa 339 aa 21.5 %
Leishmania major protein kinase, putative Glycogen synthase kinase-3   483 aa 417 aa 24.7 %
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 5 260 aa 307 aa 28.3 %
Entamoeba histolytica protein kinase, putative Glycogen synthase kinase-3   483 aa 411 aa 27.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0103 0.2187 0.2103
Plasmodium vivax glycogen synthase kinase 3, putative 0.006 0.0561 0.2085
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0106 0.2292 0.9332
Brugia malayi Protein kinase domain containing protein 0.0106 0.2292 0.5781
Loa Loa (eye worm) hypothetical protein 0.0107 0.2343 0.2261
Echinococcus granulosus dual specificity 0.011 0.2449 0.2368
Trichomonas vaginalis cyclins, putative 0.0062 0.061 0.2304
Loa Loa (eye worm) hypothetical protein 0.0148 0.3888 0.3823
Entamoeba histolytica protein kinase domain containing protein 0.011 0.2449 1
Trichomonas vaginalis cyclin B, putative 0.009 0.1689 0.7241
Echinococcus granulosus cyclin B 0.009 0.1689 0.16
Trypanosoma brucei cdc2-related kinase 1 0.0106 0.2292 0.9332
Schistosoma mansoni cyclin B 0.009 0.1689 0.16
Loa Loa (eye worm) hypothetical protein 0.0051 0.0224 0.0119
Plasmodium falciparum protein kinase 5 0.0106 0.2292 1
Trypanosoma brucei mitotic cyclin 6 0.009 0.1689 0.6758
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0048 0.0106 0.0431
Entamoeba histolytica cell division protein kinase 2, putative 0.0106 0.2292 0.9332
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.2292 1
Trypanosoma cruzi cyclin 6, putative 0.009 0.1689 0.6897
Trichomonas vaginalis cyclin A, putative 0.009 0.1689 0.7241
Trypanosoma cruzi casein kinase, putative 0.0048 0.0106 0.0431
Trypanosoma cruzi cdc2-related kinase 1 0.0106 0.2292 0.9361
Trichomonas vaginalis cyclins, putative 0.009 0.1689 0.7241
Trichomonas vaginalis cyclins, putative 0.009 0.1689 0.7241
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.011 0.2449 1
Entamoeba histolytica protein kinase domain containing protein 0.006 0.0561 0.1946
Trypanosoma cruzi cyclin, putative 0.009 0.1689 0.6897
Trypanosoma cruzi CYC2-like cyclin, putative 0.009 0.1689 0.6897
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.006 0.0561 0.1946
Schistosoma mansoni serine/threonine protein kinase 0.0106 0.2292 0.221
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.2292 1
Giardia lamblia Kinase, CMGC GSK 0.006 0.0561 0.2085
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0224 0.0119
Brugia malayi Cyclin, N-terminal domain containing protein 0.009 0.1689 0.4186
Echinococcus granulosus cyclin dependent kinase 5 0.0106 0.2292 0.221
Echinococcus granulosus cyclin dependent kinase 0.0106 0.2292 0.221
Trypanosoma cruzi casein kinase, putative 0.0048 0.0106 0.0431
Trichomonas vaginalis cyclin B, putative 0.009 0.1689 0.7241
Brugia malayi intracellular kinase 0.006 0.0561 0.1205
Entamoeba histolytica cyclin, putative 0.009 0.1689 0.6758
Entamoeba histolytica protein kinase, putative 0.011 0.2449 1
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0106 0.2292 0.221
Trypanosoma cruzi cdc2-related kinase 3 0.0106 0.2292 0.9361
Loa Loa (eye worm) hypothetical protein 0.009 0.1689 0.16
Onchocerca volvulus 0.0048 0.0106 0.0625
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0106 0.2292 0.221
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0561 0.2085
Trypanosoma cruzi cdc2-related kinase 1 0.0106 0.2292 0.9361
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0106 0.2292 0.221
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.011 0.2449 1
Trypanosoma cruzi casein kinase, putative 0.0048 0.0106 0.0431
Giardia lamblia G2/mitotic-specific cyclin B 0.009 0.1689 0.7241
Loa Loa (eye worm) hypothetical protein 0.0309 1 1
Trypanosoma cruzi cyclin, putative 0.009 0.1689 0.6897
Echinococcus granulosus glycogen synthase kinase 3 beta 0.006 0.0561 0.0461
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0224 0.0312
Brugia malayi hypothetical protein 0.0148 0.3888 1
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.006 0.0561 0.0461
Giardia lamblia Kinase, CMGC GSK 0.006 0.0561 0.2085
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.2292 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.3888 0.3823
Brugia malayi cell division control protein 2 homolog 0.0106 0.2292 0.5781
Echinococcus multilocularis cyclin B 0.009 0.1689 0.16
Giardia lamblia Kinase, CMGC CDK 0.0106 0.2292 1
Plasmodium falciparum glycogen synthase kinase 3 0.006 0.0561 0.2085
Loa Loa (eye worm) CMGC/GSK protein kinase 0.006 0.0561 0.0461
Loa Loa (eye worm) hypothetical protein 0.0107 0.2343 0.2261
Onchocerca volvulus 0.009 0.1689 1
Entamoeba histolytica protein kinase, putative 0.011 0.2449 1
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.011 0.2449 1
Schistosoma mansoni serine/threonine protein kinase 0.011 0.2449 0.2368
Loa Loa (eye worm) CMGC/GSK protein kinase 0.006 0.0561 0.0461
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0309 1 1
Leishmania major cyclin 0.009 0.1689 0.6758
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.006 0.0561 0.2293
Trypanosoma cruzi casein kinase, putative 0.0048 0.0106 0.0431
Trypanosoma brucei protein kinase, putative 0.006 0.0561 0.1946
Echinococcus multilocularis cyclin dependent kinase 0.0106 0.2292 0.221
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0561 0.2085
Echinococcus multilocularis cyclin dependent kinase 1 0.0106 0.2292 0.221
Entamoeba histolytica protein kinase domain containing protein 0.006 0.0561 0.1946
Loa Loa (eye worm) hypothetical protein 0.0052 0.0266 0.0162
Trypanosoma brucei cdc2-related kinase 3 0.0106 0.2292 0.9332
Trichomonas vaginalis cyclins, putative 0.009 0.1689 0.7241
Plasmodium vivax protein kinase Crk2 0.0106 0.2292 1
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.011 0.2449 1
Echinococcus multilocularis protein kinase shaggy 0.006 0.0561 0.0461
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.009 0.1689 0.6758
Brugia malayi Cyclin, N-terminal domain containing protein 0.009 0.1689 0.4186
Trichomonas vaginalis cyclin B, putative 0.009 0.1689 0.7241
Entamoeba histolytica hypothetical protein 0.011 0.2449 1
Trypanosoma cruzi cdc2-related kinase 3 0.0106 0.2292 0.9361
Onchocerca volvulus 0.006 0.0561 0.3324
Schistosoma mansoni serine/threonine protein kinase 0.0106 0.2292 0.221
Echinococcus multilocularis cyclin dependent kinase 5 0.0106 0.2292 0.221
Echinococcus granulosus protein kinase shaggy 0.006 0.0561 0.0461
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0106 0.2292 1
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.011 0.2449 0.2368
Trichomonas vaginalis cyclin B, putative 0.009 0.1689 0.7241
Giardia lamblia Kinase, CMGC CDK 0.0106 0.2292 1
Echinococcus multilocularis cyclin dependent kinase 1 0.0106 0.2292 0.221
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0224 0.0312
Entamoeba histolytica protein kinase, putative 0.006 0.0561 0.1946
Echinococcus multilocularis dual specificity 0.011 0.2449 0.2368
Loa Loa (eye worm) hypothetical protein 0.009 0.1689 0.16
Trichomonas vaginalis cyclins, putative 0.009 0.1689 0.7241
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0106 0.2292 0.221
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0106 0.2292 0.9332
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0309 1 1
Entamoeba histolytica cell division protein kinase 2, putative 0.0106 0.2292 0.9332
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.006 0.0561 0.2085
Trypanosoma cruzi casein kinase, putative 0.0048 0.0106 0.0431
Echinococcus granulosus cyclin dependent kinase 1 0.0106 0.2292 0.221
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.006 0.0561 0.0461
Brugia malayi Protein kinase domain containing protein 0.011 0.2449 0.6195

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) Inhibition of Asteroidea (starfish) Cyclin-dependent kinase 1/cyclin B isolated from oocyte using histone H1 and [gamma33P]ATP as substrate after 30 min by scintillation counting ChEMBL. No reference
IC50 (binding) = 0.11 uM Inhibition of human recombinant CDK5/p25 using histone H1 and [gamma33P]ATP as substrate after 30 min by scintillation counting ChEMBL. No reference
IC50 (binding) = 0.11 uM Inhibition of human recombinant CDK2/cyclin A using histone H1 and [gamma33P]ATP as substrate after 30 min by scintillation counting ChEMBL. No reference
IC50 (binding) = 0.32 uM Inhibition of Sus scrofa (pig) casein kinase 1delta/epsilon isolated from brain using RRKHAAIGpSAYSITA and [gamma33P]ATP as substrate after 30 min by scintillation counting ChEMBL. No reference
IC50 (binding) = 3 uM Inhibition of Homo sapiens (human) recombinant GST-tagged DYRK1A expressed in Escherichia coli using KKISGRLSPIMTEQ and [gamma33P]ATP as substrate after 30 min by scintillation counting ChEMBL. No reference
IC50 (binding) > 10 uM Inhibition of Sus scrofa (pig) glycogen synthase kinase 3alpha/beta isolated from brain using YRRAAVPPSPSLSRHSSPHQpSEDEEE and [gamma33P]ATP as substrate after 30 min by liquid scintillation counting ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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