TDR Targets

Basic information

Technical information

TDR Targets ID: 1805463
Name: 1-(3-methoxyphenoxy)butan-2-yl N-(phenylmethy l)carbamate
MW: 329.39 | Formula: C19H23NO4
H donors: 1 H acceptors: 1 LogP: 4.04 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: CCC(OC(=O)NCc1ccccc1)COc1cccc(c1)OC
InChi: 1S/C19H23NO4/c1-3-16(14-23-18-11-7-10-17(12-18)22-2)24-19(21)20-13-15-8-5-4-6-9-15/h4-12,16H,3,13-14H2,1-2H3,(H,20,21)
InChiKey: OZDJSECZACNOAD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-[(3-methoxyphenoxy)methyl]propyl N-(phenylmethyl)carbamate
N-(phenylmethyl)carbamic acid 1-[(3-methoxyphenoxy)methyl]propyl ester
N-(benzyl)carbamic acid 1-[(3-methoxyphenoxy)methyl]propyl ester

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)	15-cis-phytoene desaturase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium tuberculosis	Possible oxidoreductase	Get druggable targets OG5_136205	All targets in OG5_136205

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	lamin dm0	0.0026	0.0188	0.0584
Leishmania major	cytochrome p450-like protein	0.0029	0.0217	0.1798
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0025	0.0173	0.1493
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0025	0.0173	0.5
Loa Loa (eye worm)	cytochrome P450 family protein	0.0046	0.0454	0.0454
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0188	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0006	0.0006
Mycobacterium ulcerans	dehydrogenase	0.0025	0.0173	0.2466
Leishmania major	UDP-galactopyranose mutase	0.0025	0.0173	0.1217
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0054	0.0563	0.6385
Loa Loa (eye worm)	cytochrome P450	0.0029	0.0217	0.0217
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	0.0064	0.0696	0.8151
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0075	0.0835	1
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0075	0.0835	1
Mycobacterium ulcerans	cytochrome P450 144A4 Cyp144A4	0.0029	0.0217	0.3642
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0029	0.0217	0.0188
Schistosoma mansoni	cytochrome P450	0.0029	0.0217	0.0446
Mycobacterium ulcerans	oxidoreductase	0.0025	0.0173	0.2466
Trypanosoma cruzi	cytochrome P450, putative	0.0046	0.0454	0.4937
Echinococcus multilocularis		0.0025	0.0173	0.0537
Mycobacterium ulcerans	cytochrome P450 187A4 Cyp187A4	0.0029	0.0217	0.3642
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0075	0.0835	0.2664
Mycobacterium ulcerans	cytochrome P450 126A3 Cyp126A3	0.0029	0.0217	0.3642
Trichomonas vaginalis	CMGC family protein kinase	0.0054	0.0563	0.6385
Mycobacterium ulcerans	cytochrome P450 123A3 Cyp123A3	0.0029	0.0217	0.3642
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0029	0.0217	0.0188
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0173	0.0173
Mycobacterium ulcerans	protoporphyrinogen oxidase	0.0025	0.0173	0.2466
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0075	0.0835	1
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0029	0.0217	0.0188
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0025	0.0173	0.0302
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.0029	0.0217	0.1798
Echinococcus multilocularis	dual specificity protein kinase clk2	0.0064	0.0696	0.2216
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0029	0.0217	0.0188
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.0082	0.0082
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0025	0.0173	0.1217
Mycobacterium ulcerans	cytochrome P450 125A7 Cyp125A7	0.0029	0.0217	0.3642
Mycobacterium ulcerans	cytochrome P450 143A3 Cyp143A3	0.0029	0.0217	0.3642
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0075	0.0835	1
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0029	0.0217	0.0188
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0182	0.0182
Echinococcus granulosus	intermediate filament protein	0.0026	0.0188	0.0584
Mycobacterium ulcerans	cytochrome P450 189A7 Cyp189A7	0.0029	0.0217	0.3642
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0188	0.0188
Plasmodium vivax	serine/threonine kinase-1, putative	0.0064	0.0696	1
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0029	0.0217	0.0188
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0054	0.0563	0.7834
Mycobacterium ulcerans	cytochrome P450 191A3 Cyp191A3	0.0029	0.0217	0.3642
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0075	0.0835	0.2482
Echinococcus multilocularis	lamin	0.0026	0.0188	0.0584
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0025	0.0173	0.0537
Loa Loa (eye worm)	CYP4Cod1	0.0046	0.0454	0.0454
Brugia malayi	SWIRM domain containing protein	0.0025	0.0173	0.0149
Loa Loa (eye worm)	cytochrome P450 family protein	0.0047	0.0465	0.0465
Plasmodium falciparum	protein serine/threonine kinase-1	0.0064	0.0696	1
Onchocerca volvulus		0.0026	0.0188	0.0049
Trypanosoma cruzi	cytochrome P450, putative	0.0046	0.0454	0.4937
Mycobacterium ulcerans	cytochrome P450 187A5 Cyp187A5	0.0029	0.0217	0.3642
Schistosoma mansoni	lamin	0.0026	0.0188	0.035
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0029	0.0217	0.0188
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0025	0.0173	0.0537
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0018	0.0082	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0029	0.0217	0.0188
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0835	0.0835
Onchocerca volvulus		0.0245	0.3097	0.9933
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0029	0.0217	0.0188
Echinococcus multilocularis	musashi	0.0026	0.0188	0.0584
Echinococcus granulosus	mitogen activated protein kinase	0.0054	0.0563	0.1789
Mycobacterium ulcerans	monoamine oxidase	0.0025	0.0173	0.2466
Leishmania major	cytochrome p450-like protein	0.0046	0.0454	0.4937
Brugia malayi	intermediate filament protein	0.0026	0.0188	0.0163
Brugia malayi	Protein kinase domain containing protein	0.0064	0.0696	0.0673
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0029	0.0217	0.0188
Echinococcus multilocularis		0.0029	0.0217	0.0678
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.0082	0.0242
Echinococcus multilocularis		0.0063	0.0676	0.2153
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0054	0.0563	0.1789
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0054	0.0563	0.0563
Echinococcus multilocularis	mitogen activated protein kinase	0.0054	0.0563	0.1789
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0188	0.0188
Schistosoma mansoni	amine oxidase	0.0025	0.0173	0.0302
Brugia malayi	Cytochrome P450 family protein	0.0047	0.0465	0.0442
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0075	0.0835	1
Brugia malayi	Cytochrome P450 family protein	0.0029	0.0217	0.0193
Echinococcus granulosus	hypothetical protein	0.0063	0.0676	0.2153
Mycobacterium ulcerans	cytochrome P450 136A2 Cyp136A2	0.0029	0.0217	0.3642
Mycobacterium ulcerans	cytochrome P450 108B4 Cyp108B4	0.0029	0.0217	0.3642
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0173	0.0173
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	0.0064	0.0696	0.8151
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0025	0.0025
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0025	0.0173	0.0127
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0029	0.0217	0.1798
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0025	0.0173	0.1493
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0025	0.0173	0.0537
Schistosoma mansoni	serine/threonine protein kinase	0.0064	0.0696	0.2023
Trypanosoma brucei	protein kinase, putative	0.0054	0.0563	0.6385
Mycobacterium ulcerans	cytochrome P450 150A6 Cyp150A6	0.0029	0.0217	0.3642
Mycobacterium ulcerans	cytochrome P450 188A3 Cyp188A3	0.0029	0.0217	0.3642
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0025	0.0173	0.1217
Mycobacterium ulcerans	cytochrome p450 150 cyp150	0.0029	0.0217	0.3642
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0029	0.0217	0.0188
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0046	0.0454	1
Mycobacterium leprae	putative cytochrome p450	0.0029	0.0217	1
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	0.0064	0.0696	0.8151
Schistosoma mansoni	hypothetical protein	0.0029	0.0217	0.0446
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0025	0.0173	0.0302
Brugia malayi	Cytochrome P450 family protein	0.0046	0.0454	0.043
Trichomonas vaginalis	CMGC family protein kinase	0.0064	0.0696	0.8151
Mycobacterium ulcerans	cytochrome P450 140A5 Cyp140A5	0.0029	0.0217	0.3642
Plasmodium vivax	hypothetical protein, conserved	0.0025	0.0173	0.1493
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0025	0.0173	0.2466
Trypanosoma brucei	cytochrome P450, putative	0.0046	0.0454	0.4937
Brugia malayi	MAP kinase sur-1	0.0054	0.0563	0.0539
Loa Loa (eye worm)	cytochrome P450 family protein	0.0046	0.0454	0.0454
Toxoplasma gondii	histone lysine-specific demethylase	0.0025	0.0173	0.1493
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0029	0.0217	0.0188
Mycobacterium ulcerans	cytochrome P450 105Q4 Cyp105Q4	0.0029	0.0217	0.3642
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.0082	0.0057
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0029	0.0217	0.0188
Toxoplasma gondii	cytochrome p450 superfamily protein	0.0029	0.0217	0.2206
Echinococcus granulosus	dual specificity protein kinase clk2	0.0064	0.0696	0.2216
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0029	0.0217	0.0188
Mycobacterium ulcerans	cytochrome P450 143A4 Cyp143A4	0.0029	0.0217	0.3642
Echinococcus multilocularis	rho associated protein kinase	0.0246	0.3117	1
Echinococcus granulosus	lamin	0.0026	0.0188	0.0584
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0029	0.0217	0.0188
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0173	0.0173
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0029	0.0217	0.0188
Trichomonas vaginalis	CMGC family protein kinase	0.0054	0.0563	0.6385
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0054	0.0563	0.6385
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0054	0.0563	0.6385
Schistosoma mansoni	serine/threonine protein kinase	0.0054	0.0563	0.1585
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0054	0.0563	0.6385
Giardia lamblia	Kinase, CMGC MAPK	0.0054	0.0563	0.6385
Loa Loa (eye worm)	CMGC/CLK protein kinase	0.0064	0.0696	0.0696
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0075	0.0835	0.2664
Schistosoma mansoni	lamin	0.0026	0.0188	0.035
Echinococcus granulosus	ubiquitin specific protease 41	0.0075	0.0835	0.2664
Leishmania major	protein kinase, putative	0.0064	0.0696	0.8151
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0025	0.0173	0.1493
Trichomonas vaginalis	CMGC family protein kinase	0.0054	0.0563	0.6385
Loa Loa (eye worm)	AGC/DMPK/ROCK protein kinase	0.0763	1	1
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0188	0.035
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0054	0.0563	0.6385
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	0.0064	0.0696	0.8151
Trypanosoma brucei	kinetoplastid kinetochore protein 19	0.0064	0.0696	0.8151
Onchocerca volvulus		0.0026	0.0188	0.0049
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0075	0.0835	0.2482
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0075	0.0835	1
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0075	0.0835	0.2664
Mycobacterium ulcerans	cytochrome P450 142A3 Cyp142A3	0.0029	0.0217	0.3642
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0188	0.0188
Mycobacterium ulcerans	cytochrome P450 124A1, Cyp124A1	0.0029	0.0217	0.3642
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0676	0.0676
Brugia malayi	Cytochrome P450 family protein	0.0046	0.0454	0.043
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0074	0.0074
Brugia malayi	cytochrome P450	0.0029	0.0217	0.0193
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0075	0.0835	1
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0075	0.0835	0.0812
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0025	0.0173	0.2466
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0075	0.0835	0.2664
Brugia malayi	amine oxidase, flavin-containing family protein	0.0025	0.0173	0.0149
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0025	0.0173	0.1493
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0054	0.0563	0.6385
Trichomonas vaginalis	conserved hypothetical protein	0.0075	0.0835	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0173	0.0173
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.0029	0.0217	0.1798
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0025	0.0173	0.0537
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0018	0.0082	0.5
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.0082	0.0242
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0029	0.0217	0.0188
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.0025	0.0173	0.1493
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0029	0.0217	0.0188
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0173	0.0173
Mycobacterium tuberculosis	Possible oxidoreductase	0.0558	0.7276	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0234	0.2949	0.2949
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0054	0.0563	0.6385
Echinococcus granulosus	rho-associated protein kinase 1	0.0246	0.3117	1
Plasmodium falciparum	protoporphyrinogen oxidase	0.0025	0.0173	0.1493
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0029	0.0217	0.0188
Echinococcus granulosus	lamin dm0	0.0026	0.0188	0.0584
Echinococcus granulosus	cytochrome P450 2K1	0.0029	0.0217	0.0678
Mycobacterium leprae	Conserved hypothetical protein	0.0029	0.0217	1
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0029	0.0217	0.0188
Brugia malayi	follicle stimulating hormone receptor	0.0234	0.2949	0.2931
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0173	0.0173
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0075	0.0835	1
Toxoplasma gondii	cell-cycle-associated protein kinase CLK, putative	0.0064	0.0696	1
Trypanosoma brucei	kinetoplastid kinetochore protein 10	0.0064	0.0696	0.8151
Schistosoma mansoni	serine/threonine protein kinase	0.0246	0.3117	1
Leishmania major	cytochrome p450-like protein	0.0029	0.0217	0.1798
Plasmodium vivax	hypothetical protein, conserved	0.0025	0.0173	0.1493
Trichomonas vaginalis	CMGC family protein kinase	0.0054	0.0563	0.6385
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.0029	0.0217	0.1798
Brugia malayi	hypothetical protein	0.0025	0.0173	0.0149
Echinococcus granulosus	mitogen activated protein kinase 3	0.0054	0.0563	0.1789
Mycobacterium ulcerans	cytochrome P450 51B1 Cyp51B1	0.0029	0.0217	0.3642
Giardia lamblia	Kinase, CMGC CLK	0.0064	0.0696	0.8151
Schistosoma mansoni	amine oxidase	0.0025	0.0173	0.0302
Echinococcus multilocularis	ubiquitin specific protease 41	0.0075	0.0835	0.2664
Schistosoma mansoni	serine/threonine protein kinase	0.0064	0.0696	0.2023
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0029	0.0217	0.1798
Onchocerca volvulus		0.0246	0.3117	1
Leishmania major	protein kinase, putative	0.0064	0.0696	0.8151

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 4	Inhibition of Capsicum annuum (pepper) zeta-carotene desaturase expressed in Escherichia coli using zeta-carotene as substrate after 8 hr by Dixon plot analysis	ChEMBL.	12720390
IC50 (binding)	= 6.8	Inhibition of Synechococcus PCC 7942 phytoene desaturase expressed in Escherichia coli JM101 using phytoene as substrate after 8 hr by Dixon plot analysis	ChEMBL.	12720390

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2272710

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1805463