Detailed information for compound 183871

Basic information

Technical information
  • TDR Targets ID: 183871
  • Name: tert-butyl N-[3-[3-[4-(2-methoxyphenyl)-2,5-d ioxopyrrol-3-yl]pyrrolo[2,3-b]pyridin-1-yl]pr opyl]carbamate
  • MW: 476.524 | Formula: C26H28N4O5
  • H donors: 2 H acceptors: 4 LogP: 2.88 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1C1=C(C(=O)NC1=O)c1cn(c2c1cccn2)CCCNC(=O)OC(C)(C)C
  • InChi: 1S/C26H28N4O5/c1-26(2,3)35-25(33)28-13-8-14-30-15-18(16-10-7-12-27-22(16)30)21-20(23(31)29-24(21)32)17-9-5-6-11-19(17)34-4/h5-7,9-12,15H,8,13-14H2,1-4H3,(H,28,33)(H,29,31,32)
  • InChiKey: MJSXSLBYCSPRHR-UHFFFAOYSA-N  


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Synonyms

  • tert-butyl N-[3-[3-[4-(2-methoxyphenyl)-2,5-dioxo-pyrrol-3-yl]pyrrolo[2,3-b]pyridin-1-yl]propyl]carbamate
  • N-[3-[3-[4-(2-methoxyphenyl)-2,5-dioxo-3-pyrrolyl]-1-pyrrolo[2,3-b]pyridinyl]propyl]carbamic acid tert-butyl ester
  • N-[3-[3-[2,5-diketo-4-(2-methoxyphenyl)-3-pyrrolin-3-yl]pyrrolo[2,3-b]pyridin-1-yl]propyl]carbamic acid tert-butyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ribosomal protein S6 kinase, 90kDa, polypeptide 3 Starlite/ChEMBL References
Homo sapiens glycogen synthase kinase 3 beta Starlite/ChEMBL References
Homo sapiens cyclin B3 Starlite/ChEMBL References
Homo sapiens cyclin B2 Starlite/ChEMBL References
Homo sapiens cyclin A1 Starlite/ChEMBL References
Homo sapiens 3-phosphoinositide dependent protein kinase 1 Starlite/ChEMBL References
Homo sapiens cyclin B1 References
Homo sapiens cyclin-dependent kinase 3 References
Homo sapiens LYN proto-oncogene, Src family tyrosine kinase Starlite/ChEMBL References
Homo sapiens protein kinase C, beta Starlite/ChEMBL References
Homo sapiens cyclin A2 References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum IPR000719,Protein kinase,domain-containing Get druggable targets OG5_128147 All targets in OG5_128147
Trypanosoma congolense Cyclin, N-terminal domain/Cyclin, C-terminal domain containing protein, putative Get druggable targets OG5_126649 All targets in OG5_126649
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_134175 All targets in OG5_134175
Schistosoma japonicum ko:K06276 3-phosphoinositide dependent protein kinase-1, putative Get druggable targets OG5_128785 All targets in OG5_128785
Brugia malayi ribosomal protein S6 kinase alpha 3 Get druggable targets OG5_128147 All targets in OG5_128147
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 Get druggable targets OG5_128785 All targets in OG5_128785
Leishmania major cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum IPR002155,Thiolase,domain-containing Get druggable targets OG5_134175 All targets in OG5_134175
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_128785 All targets in OG5_128785
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) AGC/RSK/RSK protein kinase Get druggable targets OG5_128147 All targets in OG5_128147
Candida albicans protein kinase C similar to S. cerevisiae PKC1 (YBL105C) Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei gambiense cyclin 6,mitotic cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_128147 All targets in OG5_128147
Trypanosoma congolense mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum Protein kinase C gamma type, putative Get druggable targets OG5_129482 All targets in OG5_129482
Leishmania infantum CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum Calcium-dependent protein kinase C, putative Get druggable targets OG5_129482 All targets in OG5_129482
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin A, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_128147 All targets in OG5_128147
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus Protein kinase C brain isozyme Get druggable targets OG5_129482 All targets in OG5_129482
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
Onchocerca volvulus Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania braziliensis cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129482 All targets in OG5_129482
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 Get druggable targets OG5_128147 All targets in OG5_128147
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative Get druggable targets OG5_128147 All targets in OG5_128147
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 Get druggable targets OG5_128147 All targets in OG5_128147
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans likely B-type cyclin similar to S. cerevisiae CLB4 (YLR210W) and CLB3 (YDL155W) involved in G1/S transition Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans protein kinase C similar to S. cerevisiae PKC1 (YBL105C) Get druggable targets OG5_129482 All targets in OG5_129482
Leishmania infantum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium parvum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis serine threonine protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis mitotic cyclin-CYC2 Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus protein kinase C gamma type Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans similar to S. cerevisiae protein kinases PKH1 (YDR490C) and PKH2 (YOL100W) involved in MAPKKK cascade Get druggable targets OG5_128785 All targets in OG5_128785
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum Protein kinase C alpha type, putative Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Protein kinase c protein 2 Get druggable targets OG5_129482 All targets in OG5_129482
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi phosphoinositide-dependent protein kinase I Get druggable targets OG5_128785 All targets in OG5_128785
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis RNA directed DNA polymerase Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma mansoni cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana rac serine-threonine kinase, putative,protein kinase, putative Get druggable targets OG5_128147 All targets in OG5_128147
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129482 All targets in OG5_129482
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Protein kinase C alpha type, putative Get druggable targets OG5_129482 All targets in OG5_129482
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum IPR000719,Protein kinase;IPR011009,Protein kinase-like,domain-containing Get druggable targets OG5_128147 All targets in OG5_128147
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_128147 All targets in OG5_128147
Echinococcus granulosus RNA directed DNA polymerase Get druggable targets OG5_129482 All targets in OG5_129482
Giardia lamblia Kinase, AGC AKT Get druggable targets OG5_128147 All targets in OG5_128147
Leishmania braziliensis rac serine-threonine kinase, putative,protein kinase, putative Get druggable targets OG5_128147 All targets in OG5_128147
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis G2:mitotic specific cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum Ribosomal protein S6 kinase alpha-2, putative Get druggable targets OG5_128147 All targets in OG5_128147
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis Protein kinase C, brain isozyme Get druggable targets OG5_129482 All targets in OG5_129482
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_128785 All targets in OG5_128785
Schistosoma mansoni cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_128785 All targets in OG5_128785
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) cyclin domain-containing protein Get druggable targets OG5_134175 All targets in OG5_134175
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) AGC/PDK1 protein kinase Get druggable targets OG5_128785 All targets in OG5_128785
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum IPR000477,RNA-directed DNA polymerase (Reverse transcriptase),domain-containing Get druggable targets OG5_129482 All targets in OG5_129482
Giardia lamblia G2/mitotic-specific cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) AGC/PDK1 protein kinase Get druggable targets OG5_128785 All targets in OG5_128785
Candida albicans similar to S. cerevisiae protein kinases PKH1 (YDR490C) and PKH2 (YOL100W) involved in MAPKKK cascade Get druggable targets OG5_128785 All targets in OG5_128785
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum rac serine-threonine kinase, putative,protein kinase, putative Get druggable targets OG5_128147 All targets in OG5_128147
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_128785 All targets in OG5_128785
Echinococcus multilocularis cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus granulosus G2:mitotic specific cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_128785 All targets in OG5_128785
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_128785 All targets in OG5_128785
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_134175 All targets in OG5_134175
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 Get druggable targets OG5_128785 All targets in OG5_128785
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis telomerase reverse transcriptase subunit Get druggable targets OG5_129482 All targets in OG5_129482
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani rac serine-threonine kinase, putative Get druggable targets OG5_128147 All targets in OG5_128147
Leishmania mexicana CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.001 0.0018 0.0018
Schistosoma mansoni Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial 0.0099 0.1119 0.1119
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0236 0.2811 0.2811
Loa Loa (eye worm) hypothetical protein 0.0025 0.0195 0.0195
Trypanosoma cruzi cdc2-related kinase 3 0.0054 0.0556 0.0369
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0061 0.0639 0.0639
Loa Loa (eye worm) hypothetical protein 0.0214 0.254 0.254
Brugia malayi Cyclin, N-terminal domain containing protein 0.0025 0.0195 0.0193
Brugia malayi Probable isocitrate dehydrogenase 0.0099 0.1119 0.1117
Brugia malayi Cyclin, N-terminal domain containing protein 0.0214 0.254 0.2538
Trypanosoma cruzi CYC2-like cyclin, putative 0.0214 0.254 0.2392
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0818 1 1
Echinococcus granulosus tyrosine protein kinase Src64B 0.001 0.0018 0.0018
Echinococcus multilocularis protein kinase shaggy 0.006 0.063 0.063
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0025 0.0195 0.0195
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0818 1 1
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0252 0.0244
Brugia malayi Cyclin, N-terminal domain containing protein 0.0236 0.2811 0.2809
Brugia malayi protein kinase C II. 0.0038 0.0361 0.0359
Giardia lamblia Kinase, CMGC GSK 0.006 0.063 0.1854
Loa Loa (eye worm) cyclin domain-containing protein 0.0025 0.0195 0.0195
Schistosoma mansoni serine/threonine protein kinase 0.0029 0.0252 0.0252
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0252 0.0244
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0639 0.1896
Echinococcus multilocularis tyrosine protein kinase Fgr 0.001 0.0018 0.0018
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0818 1 1
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0012 0.0037 0.0037
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0054 0.0556 0.0556
Echinococcus granulosus cyclin y 0.0025 0.0195 0.0195
Trichomonas vaginalis cyclin B, putative 0.0214 0.254 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.001 0.0018 0.0018
Echinococcus multilocularis cyclin dependent kinase 0.0054 0.0556 0.0556
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0556 0.1542
Giardia lamblia Hypothetical protein 0.0102 0.115 0.4072
Schistosoma mansoni cyclin G 0.0025 0.0195 0.0195
Echinococcus granulosus cyclin G2 0.0025 0.0195 0.0195
Echinococcus granulosus Protein kinase C brain isozyme 0.0086 0.095 0.095
Schistosoma mansoni vav2 0.0012 0.0037 0.0037
Brugia malayi phosphoinositide-dependent protein kinase I 0.0061 0.0639 0.0637
Echinococcus granulosus tyrosine protein kinase Fyn 0.001 0.0018 0.0018
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0556 0.1542
Echinococcus multilocularis cyclin B3 1 0.0102 0.115 0.115
Loa Loa (eye worm) hypothetical protein 0.0052 0.0528 0.0528
Trichomonas vaginalis cyclin D, putative 0.0102 0.115 0.4072
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0051 0.0526 0.0526
Trichomonas vaginalis cyclins, putative 0.0214 0.254 1
Echinococcus granulosus isocitrate dehydrogenase NAD 0.0099 0.1119 0.1119
Echinococcus multilocularis cyclin G2 0.0025 0.0195 0.0195
Echinococcus granulosus c src tyrosine kinase 0.001 0.0018 0.0018
Schistosoma mansoni serine/threonine protein kinase 0.001 0.0009 0.0009
Brugia malayi RhoGAP domain containing protein 0.0012 0.0037 0.0035
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0009 0.0002 0.0002
Brugia malayi isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 0.0099 0.1119 0.1117
Giardia lamblia Kinase, CMGC CDK 0.0054 0.0556 0.1542
Giardia lamblia Kinase, CMGC GSK 0.006 0.063 0.1854
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0029 0.0252 0.0252
Echinococcus granulosus NDR protein kinase 0.0029 0.0252 0.0252
Loa Loa (eye worm) CAMK/PKD protein kinase 0.001 0.0009 0.0009
Loa Loa (eye worm) CYL-1 protein 0.0025 0.0195 0.0195
Schistosoma mansoni cyclin G2 0.0025 0.0195 0.0195
Echinococcus multilocularis tyrosine protein kinase Src64B 0.001 0.0018 0.0018
Trypanosoma cruzi cyclin 6, putative 0.0214 0.254 0.2392
Echinococcus multilocularis cyclin B 0.0214 0.254 0.254
Brugia malayi Protein kinase domain containing protein 0.0061 0.0639 0.0637
Echinococcus multilocularis NCK adaptor protein 0.0009 0.0002 0.0002
Brugia malayi Variant SH3 domain containing protein 0.0012 0.0037 0.0035
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0252 0.0244
Schistosoma mansoni tyrosine kinase 0.001 0.0018 0.0018
Schistosoma mansoni unc-13 (munc13) 0.0108 0.1228 0.1228
Echinococcus granulosus cyclin G2 0.0025 0.0195 0.0195
Trypanosoma cruzi cdc2-related kinase 1 0.0054 0.0556 0.0369
Trypanosoma brucei rac serine-threonine kinase, putative 0.0029 0.0252 0.0058
Echinococcus multilocularis cyclins 0.0102 0.115 0.115
Entamoeba histolytica cyclin, putative 0.0214 0.254 1
Echinococcus multilocularis cyclin y 0.0025 0.0195 0.0195
Giardia lamblia Cyclin A 0.0102 0.115 0.4072
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.001 0.0018 0.0018
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0038 0.0361 0.0361
Echinococcus multilocularis protein kinase c epsilon type 0.0038 0.0361 0.0361
Schistosoma mansoni adapter molecule crk 0.0009 0.0002 0.0002
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0556 0.0556
Schistosoma mansoni cyclin l 0.0025 0.0195 0.0195
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.001 0.0009 0.0007
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0361 0.0361
Toxoplasma gondii isocitrate dehydrogenase 0.0818 1 1
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.013 0.1501 0.1501
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0012 0.0037 0.0037
Brugia malayi Protein kinase domain containing protein 0.0029 0.0252 0.025
Entamoeba histolytica protein kinase, putative 0.0061 0.0639 0.1896
Leishmania major isocitrate dehydrogenase, putative 0.0099 0.1119 0.0942
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.001 0.0018 0.0018
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.001 0.0018 0.0018
Giardia lamblia Kinase, CMGC CDK 0.0054 0.0556 0.1542
Loa Loa (eye worm) SRC-1 0.001 0.0018 0.0018
Brugia malayi protein kinase C3,putative 0.001 0.0009 0.0007
Echinococcus granulosus growth factor receptor bound protein 2 0.0009 0.0002 0.0002
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0818 1 1
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0214 0.254 0.2392
Brugia malayi Cyclin C 0.0025 0.0195 0.0193
Brugia malayi Protein kinase domain containing protein 0.001 0.0009 0.0007
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0025 0.0195 0.0195
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0252 0.0244
Echinococcus multilocularis N chimaerin 0.0012 0.0037 0.0037
Onchocerca volvulus Cyclin L homolog 0.0025 0.0195 0.0767
Echinococcus granulosus protein kinase c iota type 0.0036 0.0342 0.0342
Onchocerca volvulus 0.0025 0.0195 0.0767
Schistosoma mansoni atypical protein kinase C 0.0036 0.0342 0.0342
Brugia malayi Cyclin, N-terminal domain containing protein 0.0025 0.0195 0.0193
Echinococcus multilocularis cyclin y 0.0025 0.0195 0.0195
Schistosoma mansoni g1/s-specific cyclin C 0.0025 0.0195 0.0195
Echinococcus granulosus cyclin B 0.0214 0.254 0.254
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.0025 0.0195 0.0195
Echinococcus multilocularis Cyclin L1 0.0025 0.0195 0.0195
Entamoeba histolytica protein kinase domain containing protein 0.006 0.063 0.1854
Loa Loa (eye worm) hypothetical protein 0.0214 0.254 0.254
Schistosoma mansoni tyrosine kinase 0.001 0.0018 0.0018
Echinococcus granulosus Cyclin L1 0.0025 0.0195 0.0195
Entamoeba histolytica tartrate dehydrogenase, putative 0.0099 0.1119 0.3941
Echinococcus multilocularis cyclins 0.0102 0.115 0.115
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0086 0.095 0.095
Echinococcus multilocularis serine:threonine protein kinase N2 0.0029 0.0252 0.0252
Brugia malayi Protein kinase domain containing protein 0.0029 0.0252 0.025
Trichomonas vaginalis CMGC family protein kinase 0.006 0.063 0.1854
Trichomonas vaginalis cyclin B3, putative 0.0102 0.115 0.4072
Toxoplasma gondii hypothetical protein 0.0077 0.0846 0.0664
Echinococcus multilocularis c src tyrosine kinase 0.001 0.0018 0.0018
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0818 1 1
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.006 0.063 0.0443
Brugia malayi Tyrosine-protein kinase abl-1 0.001 0.0018 0.0016
Echinococcus granulosus cyclin dependent kinase 1 0.0054 0.0556 0.0556
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0048 0.048 0.048
Echinococcus multilocularis protein kinase c iota type 0.0036 0.0342 0.0342
Brugia malayi Cyclin, N-terminal domain containing protein 0.0025 0.0195 0.0193
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0054 0.0556 0.0556
Plasmodium vivax protein kinase Crk2 0.0054 0.0556 0.0369
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0061 0.0639 0.0639
Echinococcus multilocularis tyrosine protein kinase Fyn 0.001 0.0018 0.0018
Schistosoma mansoni cyclin k 0.0025 0.0195 0.0195
Trypanosoma cruzi cdc2-related kinase 3 0.0054 0.0556 0.0369
Echinococcus multilocularis cyclin dependent kinase 5 0.0054 0.0556 0.0556
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.115 0.4072
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0252 0.0244
Schistosoma mansoni growth factor receptor-bound protein 0.0009 0.0002 0.0002
Brugia malayi SRC-1 0.001 0.0018 0.0016
Entamoeba histolytica cyclin family protein 0.0102 0.115 0.4072
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0055 0.057 0.057
Loa Loa (eye worm) CMGC/GSK protein kinase 0.006 0.063 0.063
Echinococcus multilocularis serine:threonine protein kinase N2 0.0029 0.0252 0.0252
Entamoeba histolytica cell division protein kinase 2, putative 0.0054 0.0556 0.1542
Brugia malayi Cyclin, N-terminal domain containing protein 0.0025 0.0195 0.0193
Echinococcus granulosus NCK adaptor protein 0.0009 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0025 0.0195 0.0195
Schistosoma mansoni nck2/grb4 0.0009 0.0002 0.0002
Schistosoma mansoni serine/threonine protein kinase 0.001 0.0009 0.0009
Schistosoma mansoni cyclin B3 0.0236 0.2811 0.2811
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.001 0.0018 0.0018
Trichomonas vaginalis cyclins, putative 0.0137 0.1585 0.5928
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.095 0.095
Trichomonas vaginalis cyclin B, putative 0.0214 0.254 1
Echinococcus multilocularis cyclin t1 0.0025 0.0195 0.0195
Brugia malayi Cyclin, N-terminal domain containing protein 0.0214 0.254 0.2538
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0061 0.0639 0.0639
Brugia malayi Cyclin, N-terminal domain containing protein 0.0025 0.0195 0.0193
Echinococcus multilocularis isocitrate dehydrogenase 0.0818 1 1
Echinococcus multilocularis cyclins 0.0102 0.115 0.115
Entamoeba histolytica protein kinase domain containing protein 0.006 0.063 0.1854
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0054 0.0556 0.0556
Echinococcus multilocularis cyclin k 0.0025 0.0195 0.0195
Loa Loa (eye worm) cyclin domain-containing protein 0.0025 0.0195 0.0195
Loa Loa (eye worm) cyclin C 0.0025 0.0195 0.0195
Trypanosoma brucei protein kinase, putative 0.006 0.063 0.0443
Plasmodium vivax glycogen synthase kinase 3, putative 0.006 0.063 0.0443
Echinococcus multilocularis cyclin 0.0025 0.0195 0.0195
Entamoeba histolytica protein kinase, putative 0.006 0.063 0.1854
Schistosoma mansoni tyrosine kinase 0.001 0.0018 0.0018
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0818 1 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.001 0.0018 0.0018
Echinococcus granulosus cyclin t1 0.0025 0.0195 0.0195
Echinococcus multilocularis cyclins 0.0102 0.115 0.115
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0818 1 1
Echinococcus granulosus cyclins 0.0102 0.115 0.115
Brugia malayi Protein kinase domain containing protein 0.0029 0.0252 0.025
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0054 0.0556 0.0369
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0054 0.0556 0.0369
Entamoeba histolytica protein kinase, putative 0.0029 0.0252 0.0244
Schistosoma mansoni tyrosine kinase 0.001 0.0018 0.0018
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0252 0.0244
Giardia lamblia G2/mitotic-specific cyclin B 0.0214 0.254 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0012 0.0037 0.0037
Echinococcus granulosus serine:threonine protein kinase N2 0.0029 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0112 0.1281 0.1281
Echinococcus granulosus cyclins 0.0102 0.115 0.115
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0818 1 1
Echinococcus granulosus protein kinase c epsilon type 0.0038 0.0361 0.0361
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.006 0.063 0.063
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.006 0.063 0.0443
Plasmodium falciparum glycogen synthase kinase 3 0.006 0.063 0.0443
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0029 0.0252 0.0252
Mycobacterium ulcerans 3-isopropylmalate dehydrogenase 0.0099 0.1119 0.5
Trypanosoma brucei mitotic cyclin 6 0.0214 0.254 0.2392
Echinococcus granulosus RNA directed DNA polymerase 0.0048 0.048 0.048
Onchocerca volvulus Protein CNPPD1 homolog 0.0025 0.0195 0.0767
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.013 0.1501 0.1501
Trichomonas vaginalis cyclin B, putative 0.0214 0.254 1
Trichomonas vaginalis cyclins, putative 0.0102 0.115 0.4072
Wolbachia endosymbiont of Brugia malayi isocitrate dehydrogenase 0.0099 0.1119 0.5
Trichomonas vaginalis cyclin B, putative 0.0214 0.254 1
Echinococcus granulosus cyclins 0.0102 0.115 0.115
Mycobacterium leprae PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) 0.0099 0.1119 0.5
Loa Loa (eye worm) AGC/NDR protein kinase 0.0029 0.0252 0.0252
Echinococcus multilocularis G1:S specific cyclin D1 0.0025 0.0195 0.0195
Echinococcus multilocularis cyclins 0.0102 0.115 0.115
Schistosoma mansoni growth factor receptor-bound protein 0.0009 0.0002 0.0002
Schistosoma mansoni serine/threonine protein kinase 0.0029 0.0252 0.0252
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0061 0.0639 0.0639
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0639 0.1896
Loa Loa (eye worm) cyclin domain-containing protein 0.0025 0.0195 0.0195
Echinococcus granulosus cyclin b3 0.0102 0.115 0.115
Entamoeba histolytica protein kinase, putative 0.0029 0.0252 0.0244
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0009 0.0002 0.0002
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0027 0.0224 0.0125
Brugia malayi Isocitrate dehydrogenase subunit gamma, mitochondrial precursor 0.0099 0.1119 0.1117
Echinococcus granulosus cyclin y 0.0025 0.0195 0.0195
Entamoeba histolytica cyclin family protein 0.0102 0.115 0.4072
Schistosoma mansoni hypothetical protein 0.0025 0.0195 0.0195
Echinococcus granulosus tyrosine protein kinase Fyn 0.001 0.0018 0.0018
Schistosoma mansoni cyclin B 0.0214 0.254 0.254
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0054 0.0556 0.0556
Onchocerca volvulus Cyclin L homolog 0.0025 0.0195 0.0767
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0012 0.0037 0.0037
Brugia malayi Cyclin, N-terminal domain containing protein 0.0025 0.0195 0.0193
Schistosoma mansoni protein kinase C mu 0.001 0.0009 0.0009
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0252 0.0244
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.0639 0.0639
Loa Loa (eye worm) CMGC/GSK protein kinase 0.006 0.063 0.063
Echinococcus granulosus cyclin A3 4 0.0025 0.0195 0.0195
Trypanosoma brucei cdc2-related kinase 1 0.0054 0.0556 0.0369
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0252 0.0244
Echinococcus granulosus protein kinase C gamma type 0.0078 0.086 0.086
Trichomonas vaginalis cyclins, putative 0.0214 0.254 1
Brugia malayi cyclin fold protein 1 variant b 0.0025 0.0195 0.0193
Echinococcus multilocularis serine:threonine protein kinase 38 0.0029 0.0252 0.0252
Schistosoma mansoni isocitrate dehydrogenase 0.0099 0.1119 0.1119
Echinococcus multilocularis cyclins 0.0102 0.115 0.115
Toxoplasma gondii isocitrate dehydrogenase 0.0818 1 1
Leishmania major cyclin 0.0214 0.254 0.2392
Schistosoma mansoni serine/threonine protein kinase 0.013 0.1501 0.1501
Plasmodium falciparum protein kinase 5 0.0054 0.0556 0.0369
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0556 0.0556
Echinococcus multilocularis tyrosine protein kinase Fyn 0.001 0.0018 0.0018
Echinococcus multilocularis isocitrate dehydrogenase (NAD) subunit 0.0099 0.1119 0.1119
Echinococcus multilocularis growth factor receptor bound protein 2 0.0009 0.0002 0.0002
Brugia malayi Cyclin, N-terminal domain containing protein 0.0025 0.0195 0.0193
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0029 0.0252 0.0252
Brugia malayi Hr1 repeat family protein 0.0029 0.0252 0.025
Echinococcus multilocularis cyclin G2 0.0025 0.0195 0.0195
Loa Loa (eye worm) hypothetical protein 0.0048 0.048 0.048
Trypanosoma brucei cdc2-related kinase 3 0.0054 0.0556 0.0369
Echinococcus multilocularis tyrosine protein kinase Abl 0.001 0.0018 0.0018
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0818 1 1
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0054 0.0556 0.0369
Toxoplasma gondii AGC kinase 0.0029 0.0252 0.0058
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0252 0.0244
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0103 0.1168 0.0992
Echinococcus multilocularis tyrosine protein kinase Src42A 0.001 0.0018 0.0018
Echinococcus granulosus tyrosine protein kinase Btk29A 0.001 0.0018 0.0018
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0012 0.0037 0.0037
Loa Loa (eye worm) cyclin domain-containing protein 0.0025 0.0195 0.0195
Echinococcus multilocularis cyclin dependent kinase 1 0.0054 0.0556 0.0556
Trichomonas vaginalis CMGC family protein kinase 0.006 0.063 0.1854
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0818 1 1
Trichomonas vaginalis isocitrate dehydrogenase, putative 0.0099 0.1119 0.3941
Echinococcus granulosus N chimaerin 0.0012 0.0037 0.0037
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0818 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0029 0.0252 0.0252
Trypanosoma cruzi cdc2-related kinase 1 0.0054 0.0556 0.0369
Brugia malayi Protein kinase c protein 2 0.0059 0.0617 0.0615
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0103 0.1168 0.1166
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.006 0.063 0.0443
Loa Loa (eye worm) cyclin domain-containing protein 0.0236 0.2811 0.2811
Echinococcus granulosus glycogen synthase kinase 3 beta 0.006 0.063 0.063
Schistosoma mansoni hypothetical protein 0.0025 0.0195 0.0195
Trichomonas vaginalis cyclin B, putative 0.0102 0.115 0.4072
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0025 0.0195 0.0195
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0639 0.1896
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.001 0.0018 0.0018
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0029 0.0252 0.0252
Echinococcus granulosus cyclins 0.0102 0.115 0.115
Brugia malayi Probable isocitrate dehydrogenase 0.0099 0.1119 0.1117
Echinococcus multilocularis tyrosine protein kinase Fyn 0.001 0.0018 0.0018
Loa Loa (eye worm) cyclin domain-containing protein 0.0025 0.0195 0.0195
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0818 1 1
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0009 0.0002 0.0002
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.001 0.0009 0.0009
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.013 0.1501 0.1501
Echinococcus granulosus tyrosine protein kinase Fyn 0.001 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0099 0.1119 0.1119
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.001 0.0009 0.0009
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0029 0.0252 0.0252
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.006 0.063 0.063
Trichomonas vaginalis cyclins, putative 0.0214 0.254 1
Brugia malayi cell division control protein 2 homolog 0.0054 0.0556 0.0554
Trichomonas vaginalis cyclin A, putative 0.0214 0.254 1
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.0025 0.0195 0.0195
Echinococcus granulosus cyclin B3 1 0.0102 0.115 0.115
Trichomonas vaginalis cyclin D, putative 0.0102 0.115 0.4072
Schistosoma mansoni serine/threonine kinase 0.0029 0.0252 0.0252
Echinococcus multilocularis RNA directed DNA polymerase 0.0048 0.048 0.048
Brugia malayi Isocitrate dehydrogenase 0.0818 1 1
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0029 0.0252 0.0252
Echinococcus granulosus tyrosine protein kinase Lyn 0.0013 0.0046 0.0046
Entamoeba histolytica cyclin, putative 0.0102 0.115 0.4072
Schistosoma mansoni Cyclin fold protein 0.0025 0.0195 0.0195
Onchocerca volvulus 0.006 0.063 0.2479
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0029 0.0252 0.0252
Loa Loa (eye worm) AGC/PKN protein kinase 0.0029 0.0252 0.0252
Plasmodium falciparum cyclin 0.0102 0.115 0.0974
Echinococcus granulosus cyclin 0.0025 0.0195 0.0195
Loa Loa (eye worm) cyclin domain-containing protein 0.0025 0.0195 0.0195
Brugia malayi intracellular kinase 0.006 0.063 0.0628
Echinococcus multilocularis isocitrate dehydrogenase (NAD+) 0.0099 0.1119 0.1119
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0252 0.0244
Echinococcus granulosus cyclins 0.0025 0.0195 0.0195
Echinococcus granulosus cyclin dependent kinase 5 0.0054 0.0556 0.0556
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.095 0.095
Brugia malayi C1-like domain containing protein 0.001 0.0009 0.0007
Entamoeba histolytica protein kinase, putative 0.0029 0.0252 0.0244
Echinococcus multilocularis cyclins 0.0102 0.115 0.115
Brugia malayi p70 ribosomal S6 kinase beta 0.0029 0.0252 0.025
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.0025 0.0195 0.0195
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0236 0.2811 0.2811
Schistosoma mansoni cyclins 0.0102 0.115 0.115
Loa Loa (eye worm) hypothetical protein 0.0029 0.0252 0.0252
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0818 1 1
Echinococcus granulosus isocitrate dehydrogenase NAD subunit 0.0099 0.1119 0.1119
Echinococcus multilocularis cyclin dependent kinase 1 0.0054 0.0556 0.0556
Trypanosoma cruzi cyclin, putative 0.0214 0.254 0.2392
Echinococcus multilocularis cyclin A3 4 0.0025 0.0195 0.0195
Echinococcus granulosus cyclin dependent kinase 0.0054 0.0556 0.0556
Loa Loa (eye worm) isocitrate dehydrogenase gamma subunit 0.0099 0.1119 0.1119
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0252 0.0244
Brugia malayi hypothetical protein 0.0025 0.0195 0.0193
Brugia malayi isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0.0099 0.1119 0.1117
Brugia malayi Protein kinase domain containing protein 0.0054 0.0556 0.0554
Giardia lamblia Kinase, AGC AKT 0.0103 0.1168 0.415
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.001 0.0009 0.0009
Entamoeba histolytica protein kinase, putative 0.0029 0.0252 0.0244
Trypanosoma cruzi cyclin, putative 0.0214 0.254 0.2392
Echinococcus multilocularis cyclin b3 0.0102 0.115 0.115
Brugia malayi hypothetical protein 0.0025 0.0195 0.0193
Loa Loa (eye worm) isocitrate dehydrogenase 0.0818 1 1
Echinococcus granulosus cyclin k 0.0025 0.0195 0.0195
Onchocerca volvulus 0.0214 0.254 1
Trichomonas vaginalis cyclins, putative 0.0214 0.254 1
Loa Loa (eye worm) AGC/AKT protein kinase 0.0029 0.0252 0.0252
Echinococcus granulosus protein kinase shaggy 0.006 0.063 0.063
Echinococcus granulosus cyclins 0.0102 0.115 0.115
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0818 1 1
Entamoeba histolytica cell division protein kinase 2, putative 0.0054 0.0556 0.1542
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0556 0.1542
Schistosoma mansoni cyclin d 0.0025 0.0195 0.0195
Echinococcus granulosus G1:S specific cyclin D1 0.0025 0.0195 0.0195
Echinococcus multilocularis serine threonine protein kinase 0.0078 0.086 0.086

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 0 % Inhibition of glycogen synthase kinase-3 beta ChEMBL. 15149684
Activity (binding) = 0 % Inhibition of glycogen synthase kinase-3 beta ChEMBL. 15149684
Activity (binding) = 2 % Inhibition of Cyclin-dependent kinase 2-cyclin A ChEMBL. 15149684
Activity (binding) = 2 % Inhibition of Cyclin-dependent kinase 5-p35nck5a ChEMBL. 15149684
Activity (binding) = 2 % Inhibition of Cyclin-dependent kinase 2-cyclin A ChEMBL. 15149684
Activity (binding) = 2 % Inhibition of Cyclin-dependent kinase 5-p35nck5a ChEMBL. 15149684
Activity (binding) = 3 % Inhibition of cyclin-dependent kinase 1-cyclin B ChEMBL. 15149684
Activity (binding) = 3 % Inhibition of CDK2/cyclin E ChEMBL. 15149684
Activity (binding) = 3 % Inhibition of Cyclin-dependent kinase 3-cyclin E ChEMBL. 15149684
Activity (binding) = 3 % Inhibition of cyclin-dependent kinase 1-cyclin B ChEMBL. 15149684
Activity (binding) = 3 % Inhibition of CDK2/cyclin E ChEMBL. 15149684
Activity (binding) = 3 % Inhibition of Cyclin-dependent kinase 3-cyclin E ChEMBL. 15149684
Activity (binding) = 15 % Inhibition of PKCbetaII ChEMBL. 15149684
Activity (binding) = 15 % Inhibition of PKCbetaII ChEMBL. 15149684
Activity (binding) = 20 % Inhibition of Protein tyrosine kinase Lyn ChEMBL. 15149684
Activity (binding) = 20 % Inhibition of PDK1 ChEMBL. 15149684
Activity (binding) = 20 % Inhibition of Protein tyrosine kinase Lyn ChEMBL. 15149684
Activity (binding) = 20 % Inhibition of PDK1 ChEMBL. 15149684
Activity (binding) = 24 % Inhibition of Cyclin-dependent kinase 6-cyclin D3 ChEMBL. 15149684
Activity (binding) = 24 % Inhibition of Ribosomal S6 kinase 3 ChEMBL. 15149684
Activity (binding) = 24 % Inhibition of Cyclin-dependent kinase 6-cyclin D3 ChEMBL. 15149684
Activity (binding) = 24 % Inhibition of Ribosomal S6 kinase 3 ChEMBL. 15149684
Activity (binding) = 31 % Inhibition of Ribosomal S6 kinase 2 ChEMBL. 15149684
Activity (binding) = 31 % Inhibition of Ribosomal S6 kinase 2 ChEMBL. 15149684
Activity (binding) = 38 % Inhibition of PKCalpha ChEMBL. 15149684
Activity (binding) = 38 % Inhibition of Ribosomal S6 kinase 1 ChEMBL. 15149684
Activity (binding) = 38 % Inhibition of PKCalpha ChEMBL. 15149684
Activity (binding) = 38 % Inhibition of Ribosomal S6 kinase 1 ChEMBL. 15149684
Activity (binding) = 42 % Inhibition of Yes tyrosine kinase ChEMBL. 15149684
Activity (binding) = 42 % Inhibition of Yes tyrosine kinase ChEMBL. 15149684
Activity (binding) = 49 % Inhibition of Serine/threonine-protein kinase Chk2 ChEMBL. 15149684
Activity (binding) = 49 % Inhibition of Serine/threonine-protein kinase Chk2 ChEMBL. 15149684
Activity (binding) = 54 % Inhibition of PKCepsilon ChEMBL. 15149684
Activity (binding) = 54 % Inhibition of PKCepsilon ChEMBL. 15149684
Activity (binding) = 57 % Inhibition of PRAK, MAPK5 ChEMBL. 15149684
Activity (binding) = 57 % Inhibition of PRAK, MAPK5 ChEMBL. 15149684
Activity (binding) = 60 % Inhibition of Calcium/calmodulin-dependent protein kinase type II ChEMBL. 15149684
Activity (binding) = 60 % Inhibition of Cyclin-dependent kinase 7-cyclin H ChEMBL. 15149684
Activity (binding) = 60 % Inhibition of Calcium/calmodulin-dependent protein kinase type II ChEMBL. 15149684
Activity (binding) = 60 % Inhibition of Cyclin-dependent kinase 7-cyclin H ChEMBL. 15149684
Activity (binding) = 61 % Inhibition of MSK-1 kinase ChEMBL. 15149684
Activity (binding) = 61 % Inhibition of MSK-1 kinase ChEMBL. 15149684
Activity (binding) = 63 % Inhibition of B lymphoid tyrosine kinase ChEMBL. 15149684
Activity (binding) = 63 % Inhibition of Fyn protein kinase ChEMBL. 15149684
Activity (binding) = 63 % Inhibition of B lymphoid tyrosine kinase ChEMBL. 15149684
Activity (binding) = 63 % Inhibition of Fyn protein kinase ChEMBL. 15149684
Activity (binding) = 64 % Inhibition of AMP-activated Protein Kinase ChEMBL. 15149684
Activity (binding) = 67 % Inhibition of p56 Lck tyrosine kinase ChEMBL. 15149684
Activity (binding) = 67 % Inhibition of p56 Lck tyrosine kinase ChEMBL. 15149684
Activity (binding) = 68 % Inhibition of c-Jun N-terminal kinase 3 ChEMBL. 15149684
Activity (binding) = 68 % Inhibition of compound PRK2 ChEMBL. 15149684
Activity (binding) = 68 % Inhibition of c-Jun N-terminal kinase 3 ChEMBL. 15149684
Activity (binding) = 68 % Inhibition of compound PRK2 ChEMBL. 15149684
Activity (binding) = 71 % Inhibition of PKCtheta ChEMBL. 15149684
Activity (binding) = 71 % Inhibition of PKCtheta ChEMBL. 15149684
Activity (binding) = 74 % Inhibition of c-Src tyrosine kinase ChEMBL. 15149684
Activity (binding) = 74 % Inhibition of c-Src tyrosine kinase ChEMBL. 15149684
Activity (binding) = 76 % Inhibition of PKCgamma ChEMBL. 15149684
Activity (binding) = 76 % Inhibition of PKCgamma ChEMBL. 15149684
Activity (binding) = 78 % Inhibition of ROCK-II ChEMBL. 15149684
Activity (binding) = 78 % Inhibition of ROCK-II ChEMBL. 15149684
Activity (binding) = 81 % Inhibition of c-Jun N-terminal kinase 1-alpha 1 ChEMBL. 15149684
Activity (binding) = 81 % Inhibition of compound against mitogen-activated protein kinase 1 ChEMBL. 15149684
Activity (binding) = 81 % Inhibition of c-Jun N-terminal kinase 1-alpha 1 ChEMBL. 15149684
Activity (binding) = 81 % Inhibition of compound against mitogen-activated protein kinase 1 ChEMBL. 15149684
Activity (binding) = 82 % Inhibition of p70 Ribosomal protein S6 kinase ChEMBL. 15149684
Activity (binding) = 82 % Inhibition of p70 Ribosomal protein S6 kinase ChEMBL. 15149684
Activity (binding) = 83 % Inhibition of Fibroblast growth factor receptor 3 ChEMBL. 15149684
Activity (binding) = 83 % Inhibition of Fibroblast growth factor receptor 3 ChEMBL. 15149684
Activity (binding) = 84 % Inhibition of c-Jun N-terminal kinase 2-alpha 2 ChEMBL. 15149684
Activity (binding) = 84 % Inhibition of c-Jun N-terminal kinase 2-alpha 2 ChEMBL. 15149684
Activity (binding) = 85 % Inhibition of Casein kinase I ChEMBL. 15149684
Activity (binding) = 85 % Inhibition of MAP kinase-activated protein kinase 2 ChEMBL. 15149684
Activity (binding) = 85 % Inhibition of Casein kinase I ChEMBL. 15149684
Activity (binding) = 85 % Inhibition of MAP kinase-activated protein kinase 2 ChEMBL. 15149684
Activity (binding) = 86 % Inhibition of insulin-like growth factor I receptor ChEMBL. 15149684
Activity (binding) = 86 % Inhibition of insulin-like growth factor I receptor ChEMBL. 15149684
Activity (binding) = 87 % Inhibition of Fes kinase ChEMBL. 15149684
Activity (binding) = 87 % Inhibition of Fes kinase ChEMBL. 15149684
Activity (binding) = 88 % Inhibition of Syk protein tyrosine kinase ChEMBL. 15149684
Activity (binding) = 88 % Inhibition of Syk protein tyrosine kinase ChEMBL. 15149684
Activity (binding) = 89 % Inhibition of I kappa-B kinase alpha ChEMBL. 15149684
Activity (binding) = 89 % Inhibition of mitogen-activated protein kinase 2 ChEMBL. 15149684
Activity (binding) = 89 % Inhibition of I kappa-B kinase alpha ChEMBL. 15149684
Activity (binding) = 89 % Inhibition of mitogen-activated protein kinase 2 ChEMBL. 15149684
Activity (binding) = 91 % Inhibition of Abl kinase ChEMBL. 15149684
Activity (binding) = 91 % Inhibition of Calcium/calmodulin-dependent protein kinase type IV ChEMBL. 15149684
Activity (binding) = 91 % Inhibition of I-kappa-B-kinase beta ChEMBL. 15149684
Activity (binding) = 91 % Inhibition of ROCK-II ChEMBL. 15149684
Activity (binding) = 91 % Inhibition of Calcium/calmodulin-dependent protein kinase type IV ChEMBL. 15149684
Activity (binding) = 91 % Inhibition of I-kappa-B-kinase beta ChEMBL. 15149684
Activity (binding) = 91 % Inhibition of ROCK-II ChEMBL. 15149684
Activity (binding) = 92 % Inhibition of mitogen-activated protein kinase 2 ChEMBL. 15149684
Activity (binding) = 92 % Inhibition of RAF proto-oncogene serine/threonine-protein kinase ChEMBL. 15149684
Activity (binding) = 92 % Inhibition of mitogen-activated protein kinase 2 ChEMBL. 15149684
Activity (binding) = 92 % Inhibition of RAF proto-oncogene serine/threonine-protein kinase ChEMBL. 15149684
Activity (binding) = 93 % Inhibition of PAK2 ChEMBL. 15149684
Activity (binding) = 93 % Inhibition of PDGFRbeta ChEMBL. 15149684
Activity (binding) = 93 % Inhibition of PAK2 ChEMBL. 15149684
Activity (binding) = 93 % Inhibition of PDGFRbeta ChEMBL. 15149684
Activity (binding) = 94 % Inhibition of IR kinase ChEMBL. 15149684
Activity (binding) = 94 % Inhibition of IR kinase ChEMBL. 15149684
Activity (binding) = 95 % Inhibition of Serine/threonine-protein kinase Chk1 ChEMBL. 15149684
Activity (binding) = 95 % Inhibition of Tyrosine-protein kinase CSK ChEMBL. 15149684
Activity (binding) = 95 % Inhibition of Mitogen activated protein kinase kinase 6 ChEMBL. 15149684
Activity (binding) = 95 % Inhibition of PKA ChEMBL. 15149684
Activity (binding) = 95 % Inhibition of Serine/threonine-protein kinase Chk1 ChEMBL. 15149684
Activity (binding) = 95 % Inhibition of Tyrosine-protein kinase CSK ChEMBL. 15149684
Activity (binding) = 95 % Inhibition of Mitogen activated protein kinase kinase 6 ChEMBL. 15149684
Activity (binding) = 99 % Inhibition of PKBbeta ChEMBL. 15149684
Activity (binding) = 99 % Inhibition of PKBbeta ChEMBL. 15149684
Activity (binding) = 100 % Inhibition of mitogen activated protein kinase kinase 1 ChEMBL. 15149684
Activity (binding) = 100 % Inhibition of Stress activated protein kinase 4 ChEMBL. 15149684
Activity (binding) = 100 % Inhibition of mitogen activated protein kinase kinase 1 ChEMBL. 15149684
Activity (binding) = 100 % Inhibition of Stress activated protein kinase 4 ChEMBL. 15149684
Activity (binding) = 101 % Inhibition of Mitogen activated protein kinase kinase 4 ChEMBL. 15149684
Activity (binding) = 101 % Inhibition of Mitogen activated protein kinase kinase 7 beta ChEMBL. 15149684
Activity (binding) = 101 % Inhibition of Mitogen activated protein kinase kinase 4 ChEMBL. 15149684
Activity (binding) = 101 % Inhibition of Mitogen activated protein kinase kinase 7 beta ChEMBL. 15149684
Activity (binding) = 103 % Inhibition of Casein kinase 2 ChEMBL. 15149684
Activity (binding) = 103 % Inhibition of PKBalpha ChEMBL. 15149684
Activity (binding) = 103 % Inhibition of Casein kinase 2 ChEMBL. 15149684
Activity (binding) = 103 % Inhibition of PKBalpha ChEMBL. 15149684
Activity (binding) = 105 % Inhibition of Serum/glucocorticoid regulated kinase ChEMBL. 15149684
Activity (binding) = 105 % Inhibition of Serum/glucocorticoid regulated kinase ChEMBL. 15149684
Activity (binding) = 106 % Inhibition of Stress activated protein kinase 2b ChEMBL. 15149684
Activity (binding) = 106 % Inhibition of Stress activated protein kinase 2b ChEMBL. 15149684
Activity (binding) = 108 % Inhibition of PDGFRalpha ChEMBL. 15149684
Activity (binding) = 108 % Inhibition of PDGFRalpha ChEMBL. 15149684
Activity (binding) = 109 % Inhibition of Stress activated protein kinase 2a ChEMBL. 15149684
Activity (binding) = 109 % Inhibition of Stress activated protein kinase 2a ChEMBL. 15149684
Activity (binding) = 112 % Inhibition of bovine PKA ChEMBL. 15149684
Activity (binding) = 112 % Inhibition of Zeta-chain (TCR) associated protein kinase 70 kDa (ZAP70) ChEMBL. 15149684
Activity (binding) = 112 % Inhibition of Zeta-chain (TCR) associated protein kinase 70 kDa (ZAP70) ChEMBL. 15149684
Activity (binding) = 122 % Inhibition of Stress activated protein kinase 3 ChEMBL. 15149684
Activity (binding) = 122 % Inhibition of Stress activated protein kinase 3 ChEMBL. 15149684
EC50 (functional) = 0.04 uM Effective concentration of compound against glycogen synthase kinase-3 in HEK293 cells ChEMBL. 15149684
EC50 (functional) = 0.04 uM Effective concentration of compound against glycogen synthase kinase-3 in HEK293 cells ChEMBL. 15149684
IC50 (binding) = 0.007 uM Inhibitory concentration against rabbit glycogen synthase kinase-3 beta using protein phosphatase inhibitor-2 as substrate ChEMBL. 15149684
IC50 (binding) = 0.007 uM Inhibitory concentration against rabbit glycogen synthase kinase-3 beta using protein phosphatase inhibitor-2 as substrate ChEMBL. 15149684
IC50 (binding) = 0.068 uM Inhibition of Cyclin-dependent kinase 2-cyclin A ChEMBL. 15149684
IC50 (binding) = 0.068 uM Inhibition of Cyclin-dependent kinase 2-cyclin A ChEMBL. 15149684
IC50 (binding) = 0.17 uM Inhibition of Cyclin-dependent kinase 1-cyclin B ChEMBL. 15149684
IC50 (binding) = 0.17 uM Inhibition of Cyclin-dependent kinase 1-cyclin B ChEMBL. 15149684
IC50 (binding) = 0.57 uM Inhibition of PDK1 ChEMBL. 15149684
IC50 (binding) = 0.57 uM Inhibition of PDK1 ChEMBL. 15149684
IC50 (binding) = 0.64 uM Inhibition of Ribosomal S6 kinase 3 ChEMBL. 15149684
IC50 (binding) = 0.64 uM Inhibition of Ribosomal S6 kinase 3 ChEMBL. 15149684
IC50 (binding) = 1.8 uM Inhibition of Protein tyrosine kinase Lyn ChEMBL. 15149684
IC50 (binding) = 1.8 uM Inhibition of Protein tyrosine kinase Lyn ChEMBL. 15149684
IC50 (binding) = 2.26 uM Inhibitory concentration against human protein kinase C-betaII using histone as substrate ChEMBL. 15149684
IC50 (binding) = 2.26 uM Inhibitory concentration against human protein kinase C-betaII using histone as substrate ChEMBL. 15149684
Inhibition (binding) < 50 % Inhibitory activity of 10 uM compound against protein kinase C-alpha using histone as substrate ChEMBL. 15149684
Inhibition (binding) < 50 % Inhibitory activity of 10 uM compound against protein kinase C-gamma using histone as substrate ChEMBL. 15149684
Inhibition (binding) < 50 % Inhibitory activity of 10 uM compound against protein kinase C-alpha using histone as substrate ChEMBL. 15149684
Inhibition (binding) < 50 % Inhibitory activity of 10 uM compound against protein kinase C-gamma using histone as substrate ChEMBL. 15149684

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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