Detailed information for compound 1845738

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 766.955 | Formula: C41H66O13
  • H donors: 8 H acceptors: 9 LogP: 2.57 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 3
  • SMILES: OC[C@H]1O[C@@H](OC(=O)[C@]23CC[C@@]4(C(=CC[C@H]5[C@@]4(C)CC[C@@H]4[C@]5(C)CC[C@@H](C4(C)C)O[C@@H]4OC[C@H]([C@@H]([C@H]4O)O)O)[C@@H]3C[C@](CC2)(C)CO)C)[C@@H]([C@H]([C@@H]1O)O)O
  • InChi: 1S/C41H66O13/c1-36(2)25-9-12-40(6)26(38(25,4)11-10-27(36)53-33-31(48)28(45)23(44)19-51-33)8-7-21-22-17-37(3,20-43)13-15-41(22,16-14-39(21,40)5)35(50)54-34-32(49)30(47)29(46)24(18-42)52-34/h7,22-34,42-49H,8-20H2,1-6H3/t22-,23+,24+,25-,26+,27-,28-,29+,30-,31+,32+,33-,34-,37+,38-,39+,40+,41-/m0/s1
  • InChiKey: JUQZBNSNCFPQEN-OKBJWFIMSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis carbonic anhydrase II 0.0198 0.2903 0.2889
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0194 0.0171
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.0076 0.0812 0.0812
Echinococcus granulosus carbonic anhydrase II 0.0198 0.2903 0.2903
Mycobacterium ulcerans cytoplasmic peptidase PepQ 0.0076 0.0812 0.519
Onchocerca volvulus 0.0237 0.356 0.3548
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0035 0.0105 0.0086
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0427 0.0326
Loa Loa (eye worm) hypothetical protein 0.0205 0.3018 0.3005
Schistosoma mansoni peptidase 0.0076 0.0812 0.0795
Toxoplasma gondii transcriptional elongation factor FACT140 0.0076 0.0812 0.0795
Echinococcus granulosus carbonic anhydrase 0.0107 0.1347 0.1347
Loa Loa (eye worm) hypothetical protein 0.0076 0.0812 0.0795
Mycobacterium ulcerans methionine aminopeptidase 0.0076 0.0812 0.519
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0588 0.057
Toxoplasma gondii LsmAD domain-containing protein 0.0054 0.0427 0.0409
Loa Loa (eye worm) hypothetical protein 0.004 0.0194 0.0175
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0076 0.0812 0.079
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0076 0.0812 0.079
Toxoplasma gondii hypothetical protein 0.0035 0.0105 0.0086
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0107 0.1344 0.1328
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0019 0.0019
Trypanosoma cruzi aminopeptidase P, putative 0.0076 0.0812 0.079
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0613 1 1
Echinococcus granulosus lysine specific demethylase 5A 0.0059 0.0513 0.0513
Leishmania major transcription factor-like protein 0.0076 0.0812 0.079
Echinococcus granulosus carbonic anhydrase 0.0107 0.1347 0.1347
Echinococcus granulosus Xaa Pro aminopeptidase 3 0.0076 0.0812 0.0812
Loa Loa (eye worm) hypothetical protein 0.0076 0.0812 0.0795
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0119 0.1542 1
Loa Loa (eye worm) beta-lactamase 0.004 0.0194 0.0175
Echinococcus granulosus ankyrin repeat protein 0.0336 0.5268 0.5268
Brugia malayi beta-lactamase family protein 0.004 0.0194 0.0175
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0513 0.0513
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0194 0.0171
Schistosoma mansoni transient receptor potential cation channel subfamily A member 0.0336 0.5268 0.5259
Schistosoma mansoni carbonic anhydrase-related 0.0107 0.1347 0.1331
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0076 0.0812 0.079
Loa Loa (eye worm) hypothetical protein 0.0076 0.0812 0.0795
Echinococcus granulosus transient receptor potential cation channel 0.0347 0.5444 0.5444
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.0076 0.0812 0.0795
Echinococcus granulosus xaa pro aminopeptidase 0.0076 0.0812 0.0812
Echinococcus granulosus Proliferation associated protein 2G4 0.0076 0.0812 0.0812
Onchocerca volvulus 0.004 0.0194 0.0175
Schistosoma mansoni hypothetical protein 0.0522 0.8442 0.8439
Plasmodium falciparum methionine aminopeptidase 1c, putative 0.0076 0.0812 0.0714
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0107 0.1347 0.1331
Echinococcus granulosus sodium and chloride dependent glycine 0.0035 0.0105 0.0105
Schistosoma mansoni methionyl aminopeptidase 2 (M24 family) 0.0613 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.1048 0.1031
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0119 0.1542 0.1527
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0044 0.0025
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0513 0.0495
Onchocerca volvulus 0.0035 0.0105 0.0086
Schistosoma mansoni sodium/chloride dependent transporter 0.0035 0.0105 0.0086
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0205 0.3018 0.3005
Schistosoma mansoni hypothetical protein 0.0031 0.0044 0.0025
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0044 0.0025
Loa Loa (eye worm) hypothetical protein 0.0035 0.0105 0.0086
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0427 0.0405
Schistosoma mansoni hypothetical protein 0.0031 0.0044 0.0025
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0044 0.0025
Brugia malayi Methionine aminopeptidase protein type I 0.0076 0.0812 0.0795
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.0076 0.0812 0.079
Toxoplasma gondii methionine aminopeptidase 2, putative 0.0613 1 1
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0588 0.057
Echinococcus multilocularis sodium and chloride dependent glycine 0.0035 0.0105 0.0086
Entamoeba histolytica methionine aminopeptidase, putative 0.0613 1 1
Brugia malayi RNA binding protein 0.0063 0.0588 0.057
Echinococcus multilocularis GPCR, family 2 0.0031 0.0044 0.0025
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0613 1 1
Chlamydia trachomatis methionine aminopeptidase 0.0076 0.0812 1
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0035 0.0105 0.0086
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0044 0.0044
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0076 0.0812 0.063
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0194 0.1121
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0076 0.0812 0.063
Schistosoma mansoni aminopeptidase P homologue (M24 family) 0.0076 0.0812 0.0795
Loa Loa (eye worm) hypothetical protein 0.0035 0.0105 0.0086
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0023 0.0005
Leishmania major carbonic anhydrase-like protein 0.0198 0.2903 0.2886
Loa Loa (eye worm) solute carrier family 6 member 4 0.0205 0.3018 0.3005
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.1048 0.1048
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0119 0.1542 0.3657
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0198 0.2903 0.2889
Mycobacterium ulcerans dipeptidase 0.0076 0.0812 0.519
Brugia malayi Cytochrome P450 family protein 0.003 0.0023 0.0005
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0035 0.0105 0.0086
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0076 0.0812 0.079
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0255 0.3882 1
Brugia malayi beta-lactamase 0.004 0.0194 0.0175
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0076 0.0812 0.0795
Plasmodium vivax methionine aminopeptidase 1a, putative 0.0076 0.0812 0.0795
Plasmodium vivax methionine aminopeptidase 1c, putative 0.0076 0.0812 0.0795
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0035 0.0105 0.0086
Trypanosoma cruzi Metallopeptidase family M24, putative 0.0076 0.0812 0.079
Echinococcus granulosus FACT complex subunit SPT16 0.0076 0.0812 0.0812
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0035 0.0105 0.0086
Trypanosoma brucei Facilitates chromatin transcription complex subunit spt16 0.0076 0.0812 0.079
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.1048 0.1031
Echinococcus multilocularis methionine aminopeptidase, type I 0.0076 0.0812 0.0795
Leishmania major hypothetical protein, conserved 0.004 0.0194 0.0171
Loa Loa (eye worm) hypothetical protein 0.0054 0.0427 0.0409
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0035 0.0105 0.0105
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.0076 0.0812 0.5
Brugia malayi hypothetical protein 0.0035 0.0102 0.0083
Schistosoma mansoni hypothetical protein 0.0107 0.1347 0.1331
Giardia lamblia Methionine aminopeptidase 0.0613 1 1
Toxoplasma gondii creatinase domain-containing protein 0.0076 0.0812 0.0795
Leishmania major hypothetical protein, conserved 0.0076 0.0812 0.079
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.0076 0.0812 0.0795
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0588 0.057
Trichomonas vaginalis set domain proteins, putative 0.0236 0.3551 0.3423
Schistosoma mansoni sodium-dependent amino acid transporter 0.0035 0.0105 0.0086
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0613 1 1
Echinococcus granulosus xaa Pro dipeptidase 0.0076 0.0812 0.0812
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0545 0.3436
Trypanosoma brucei methionine aminopeptidase, putative 0.0076 0.0812 0.079
Loa Loa (eye worm) hypothetical protein 0.0035 0.0105 0.0086
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0035 0.0105 0.0086
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0545 0.0954
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0545 0.0528
Echinococcus multilocularis sodium and chloride dependent glycine 0.0035 0.0105 0.0086
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0076 0.0812 0.079
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0076 0.0812 0.079
Toxoplasma gondii methionine aminopeptidase 0.0076 0.0812 0.0795
Schistosoma mansoni hypothetical protein 0.0031 0.0044 0.0025
Brugia malayi jmjC domain containing protein 0.0059 0.0513 0.0495
Loa Loa (eye worm) hypothetical protein 0.0107 0.1347 0.1331
Trypanosoma cruzi Metallopeptidase family M24/FACT complex subunit (SPT16/CDC68)/Histone chaperone Rttp106-like, putative 0.0076 0.0812 0.079
Mycobacterium leprae Probable cytoplasmic peptidase PepQ 0.0076 0.0812 1
Echinococcus multilocularis xaa pro aminopeptidase 0.0076 0.0812 0.0795
Trypanosoma brucei PAB1-binding protein , putative 0.0054 0.0427 0.0405
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.0076 0.0812 0.079
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0513 0.0495
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0035 0.0105 0.0086
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0076 0.0812 0.079
Plasmodium falciparum aminopeptidase P 0.0076 0.0812 0.0714
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0035 0.0105 0.0086
Onchocerca volvulus Dipeptidase C homolog 0.0076 0.0812 0.0795
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0427 0.0326
Echinococcus granulosus sodium and chloride dependent glycine 0.0035 0.0105 0.0105
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0035 0.0105 0.0086
Mycobacterium tuberculosis Probable cytoplasmic peptidase PepQ 0.0076 0.0812 0.1676
Loa Loa (eye worm) RNA binding protein 0.0063 0.0588 0.057
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0205 0.3018 0.3005
Loa Loa (eye worm) hypothetical protein 0.0107 0.1347 0.1331
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.1048 0.1031
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0107 0.1347 0.1331
Loa Loa (eye worm) DNA-binding protein 0.0076 0.0812 0.0795
Echinococcus multilocularis geminin 0.0522 0.8442 0.8439
Trypanosoma brucei methionine aminopeptidase 2, putative 0.0613 1 1
Echinococcus granulosus serotonin transporter 0.0205 0.3018 0.3018
Loa Loa (eye worm) hypothetical protein 0.0035 0.0105 0.0086
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0198 0.2903 0.2889
Mycobacterium ulcerans lipase LipD 0.004 0.0194 0.1121
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0076 0.0812 0.0795
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0194 0.0175
Schistosoma mansoni carbonic anhydrase-related 0.0107 0.1347 0.1331
Echinococcus granulosus GPCR family 2 0.0031 0.0044 0.0044
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0107 0.1347 0.1331
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0035 0.0105 0.0105
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0198 0.2903 0.2886
Echinococcus multilocularis Xaa Pro aminopeptidase 3 0.0076 0.0812 0.0795
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0035 0.0105 0.0086
Brugia malayi jmjC domain containing protein 0.0059 0.0513 0.0495
Toxoplasma gondii peptidase D, putative 0.0076 0.0812 0.0795
Brugia malayi Cytochrome P450 family protein 0.0059 0.0522 0.0504
Echinococcus multilocularis carbonic anhydrase 0.0107 0.1347 0.1331
Onchocerca volvulus FACT complex subunit SPT16 homolog 0.0076 0.0812 0.0795
Onchocerca volvulus 0.004 0.0194 0.0175
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0194 0.0194
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0545 0.3436
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0107 0.1347 0.1331
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0035 0.0105 0.0105
Echinococcus granulosus carbonic anhydrase 0.0107 0.1347 0.1347
Schistosoma mansoni sodium/chloride dependent transporter 0.0205 0.3018 0.3005
Trypanosoma brucei Metallopeptidase family M24, putative 0.0076 0.0812 0.079
Loa Loa (eye worm) hypothetical protein 0.0035 0.0105 0.0086
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0076 0.0812 0.0795
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0076 0.0812 0.079
Toxoplasma gondii hypothetical protein 0.0107 0.1347 0.1331
Plasmodium vivax methionine aminopeptidase 2, putative 0.0613 1 1
Plasmodium falciparum methionine aminopeptidase 2 0.0613 1 1
Echinococcus multilocularis carbonic anhydrase 0.0107 0.1347 0.1331
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.1198 0.1182
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.0076 0.0812 0.0714
Brugia malayi DNA-binding protein, 42 kDa containing protein 0.0076 0.0812 0.0795
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.1048 0.1031
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0035 0.0105 0.0086
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0076 0.0812 0.063
Mycobacterium ulcerans methionine aminopeptidase MapB 0.0076 0.0812 0.519
Schistosoma mansoni hypothetical protein 0.0522 0.8442 0.8439
Loa Loa (eye worm) hypothetical protein 0.0205 0.3018 0.3005
Loa Loa (eye worm) hypothetical protein 0.004 0.0194 0.0175
Brugia malayi metallopeptidase family M24 containing protein 0.0076 0.0812 0.0795
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0035 0.0105 0.0086
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0076 0.0812 0.079
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0545 0.3436
Loa Loa (eye worm) norepinephrine transporter 0.0205 0.3018 0.3005
Loa Loa (eye worm) hypothetical protein 0.004 0.0194 0.0175
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) 0.0076 0.0812 1
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.0076 0.0812 0.079
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0076 0.0812 0.0795
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0545 0.0528
Brugia malayi metallopeptidase family M24 containing protein 0.0076 0.0812 0.0795
Echinococcus granulosus methionine aminopeptidase type I 0.0076 0.0812 0.0812
Wolbachia endosymbiont of Brugia malayi Xaa-Pro aminopeptidase 0.0076 0.0812 0.5
Brugia malayi Cytochrome P450 family protein 0.003 0.0023 0.0005
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0545 0.0545
Plasmodium vivax FACT complex subunit SPT16, putative 0.0076 0.0812 0.0795
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) 0.0076 0.0812 1
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0513 0.0495
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.0076 0.0812 0.0795
Loa Loa (eye worm) CYP4Cod1 0.003 0.0023 0.0005
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0119 0.1542 0.1523
Echinococcus granulosus geminin 0.0522 0.8442 0.8442
Plasmodium vivax methionine aminopeptidase 1b, putative 0.0076 0.0812 0.0795
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.1048 0.1048
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0035 0.0105 0.0086
Loa Loa (eye worm) metallopeptidase family M24 containing protein 0.0076 0.0812 0.0795
Leishmania major aminopeptidase P, putative,metallo-peptidase, Clan MG, Family M24 0.0076 0.0812 0.079
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0545 0.0528
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0105 0.0086
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0513 0.0495
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.0522 0.0504
Echinococcus multilocularis carbonic anhydrase 0.0107 0.1347 0.1331
Onchocerca volvulus 0.0205 0.3018 0.3005
Echinococcus granulosus xaa Pro dipeptidase 0.0076 0.0812 0.0812
Schistosoma mansoni carbonic anhydrase 0.0107 0.1347 0.1331
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0076 0.0812 0.079
Toxoplasma gondii ABC1 family protein 0.004 0.0194 0.0175
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.0076 0.0812 0.079
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0545 0.0528
Trypanosoma brucei Xaa-Pro aminopeptidase, putative 0.0076 0.0812 0.079
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0035 0.0105 0.0086
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0194 0.0175
Schistosoma mansoni hypothetical protein 0.0067 0.0664 0.0646
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0044 0.0044
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0076 0.0812 0.063
Schistosoma mansoni sodium/chloride dependent transporter 0.0035 0.0105 0.0086
Echinococcus multilocularis ankyrin repeat protein 0.0336 0.5268 0.5259
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0076 0.0812 0.063
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0035 0.0105 0.0086
Loa Loa (eye worm) hypothetical protein 0.004 0.0194 0.0175
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0194 0.0175
Brugia malayi TAR-binding protein 0.0063 0.0588 0.057
Loa Loa (eye worm) hypothetical protein 0.0035 0.0105 0.0086
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0107 0.1347 0.1331
Treponema pallidum sodium- and chloride- dependent transporter 0.0205 0.3018 1
Loa Loa (eye worm) initiation factor 2-associated protein 0.0613 1 1
Schistosoma mansoni Xaa-Pro dipeptidase (M24 family) 0.0076 0.0812 0.0795
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0023 0.0005
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0198 0.2903 0.2886
Echinococcus multilocularis Proliferation associated protein 2G4 0.0076 0.0812 0.0795
Plasmodium vivax peptidase, putative 0.0076 0.0812 0.0795
Brugia malayi metallopeptidase family M24 containing protein 0.0076 0.0812 0.0795
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0076 0.0812 0.063
Plasmodium falciparum carbonic anhydrase 0.0107 0.1347 0.1255
Toxoplasma gondii proliferation-associated protein 2G4, putative 0.0076 0.0812 0.0795
Loa Loa (eye worm) hypothetical protein 0.0067 0.0664 0.0646
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0613 1 1
Loa Loa (eye worm) carbonic anhydrase 3 0.0198 0.2903 0.2889
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.0076 0.0812 0.1676
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0035 0.0105 0.0086
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0076 0.0812 0.063
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0588 0.057
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0513 0.0495
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0545 0.0523
Mycobacterium ulcerans aminopeptidase 0.0076 0.0812 0.519
Echinococcus multilocularis transient receptor potential cation channel 0.0347 0.5453 0.5444
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0076 0.0812 0.063
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0427 0.0405
Schistosoma mansoni aminopeptidase P1 (M24 family) 0.0076 0.0812 0.0795
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0194 0.0171
Schistosoma mansoni chromatin-specific transcription elongation factor 140 kDa subunit (M24 family) 0.0076 0.0812 0.0795
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0513 0.0495
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0664 0.0646
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0119 0.1542 0.1542
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0035 0.0105 0.0086
Echinococcus multilocularis serotonin transporter 0.0205 0.3018 0.3005
Brugia malayi hypothetical protein 0.0035 0.0105 0.0086
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.306 0.3047
Echinococcus granulosus methionyl aminopeptidase 2 0.0613 1 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.1198 0.1182
Echinococcus multilocularis xaa Pro dipeptidase 0.0076 0.0812 0.0795
Loa Loa (eye worm) methionine aminopeptidase type I 0.0076 0.0812 0.0795
Loa Loa (eye worm) hypothetical protein 0.0107 0.1347 0.1331
Onchocerca volvulus 0.0076 0.0812 0.0795
Toxoplasma gondii hypothetical protein 0.0035 0.0105 0.0086
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0119 0.1542 0.1527
Plasmodium falciparum proliferation-associated protein 2g4, putative 0.0076 0.0812 0.0714
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.1048 0.1031
Plasmodium falciparum FACT complex subunit SPT16, putative 0.0076 0.0812 0.0714
Onchocerca volvulus 0.0035 0.0105 0.0086
Schistosoma mansoni hypothetical protein 0.0031 0.0044 0.0025
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0588 0.057
Loa Loa (eye worm) hypothetical protein 0.0099 0.1198 0.1182
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0194 0.0175
Echinococcus granulosus tar DNA binding protein 0.0063 0.0588 0.0588
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.1048 0.1031
Brugia malayi Pre-SET motif family protein 0.0207 0.306 0.3047
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0035 0.0105 0.0105
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.0076 0.0812 0.0714
Echinococcus multilocularis methionyl aminopeptidase 2 0.0613 1 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0044 0.0025
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0194 0.1121
Mycobacterium ulcerans hypothetical protein 0.004 0.0194 0.1121
Brugia malayi beta-lactamase family protein 0.004 0.0194 0.0175
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0119 0.1542 0.1527
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0198 0.2903 0.2889
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0194 0.0175
Loa Loa (eye worm) serotonin transporter b 0.0205 0.3018 0.3005
Mycobacterium ulcerans beta-lactamase 0.004 0.0194 0.1121
Onchocerca volvulus 0.0035 0.0105 0.0086
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0588 0.057
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0076 0.0812 0.063
Onchocerca volvulus Methionine aminopeptidase 2 homolog 0.0613 1 1
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0035 0.0105 0.0086
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.1048 0.1031
Loa Loa (eye worm) hypothetical protein 0.0205 0.3018 0.3005
Leishmania major hypothetical protein, conserved 0.0054 0.0427 0.0405
Mycobacterium ulcerans dipeptidase PepE 0.0076 0.0812 0.519
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0613 1 1
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.0076 0.0812 0.1676
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0076 0.0812 0.079
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0198 0.2903 0.2889
Trypanosoma brucei carbonic anhydrase-like protein 0.0198 0.2903 0.2886
Plasmodium vivax ataxin-2 like protein, putative 0.0054 0.0427 0.0409
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0119 0.1542 1
Plasmodium vivax proliferation-associated protein 2g4, putative 0.0076 0.0812 0.0795
Loa Loa (eye worm) hypothetical protein 0.0035 0.0105 0.0086
Loa Loa (eye worm) hypothetical protein 0.004 0.0194 0.0175
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0035 0.0105 0.0086
Echinococcus multilocularis xaa Pro dipeptidase 0.0076 0.0812 0.0795
Chlamydia trachomatis aminopeptidase P 0.0076 0.0812 1
Echinococcus multilocularis FACT complex subunit SPT16 0.0076 0.0812 0.0795
Mycobacterium tuberculosis Dipeptidase PepE 0.0076 0.0812 0.1676
Trypanosoma cruzi Metallopeptidase family M24, putative 0.0076 0.0812 0.079
Schistosoma mansoni carbonic anhydrase-related 0.0107 0.1347 0.1331
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0613 1 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0198 0.2903 0.2889
Plasmodium vivax hypothetical protein, conserved 0.004 0.0194 0.0175
Brugia malayi hypothetical protein 0.0054 0.0427 0.0409
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0107 0.1347 0.1331
Loa Loa (eye worm) hypothetical protein 0.004 0.0194 0.0175
Plasmodium vivax amine transporter, putative 0.0035 0.0105 0.0086
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0613 1 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0588 0.057
Onchocerca volvulus 0.004 0.0194 0.0175
Toxoplasma gondii methionine aminopeptidase 0.0076 0.0812 0.0795
Trypanosoma cruzi aminopeptidase P1, putative 0.0076 0.0812 0.079
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0588 0.057
Loa Loa (eye worm) hypothetical protein 0.0031 0.0044 0.0025
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0035 0.0105 0.0086
Leishmania major methionine aminopeptidase 2, putative 0.0613 1 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0044 0.0025
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.1198 0.1182
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0588 0.057

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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